Digital Commons Network^™

Discovery Of Direct-Acting Small-Molecule Rig-I Agonists Through Creation Of A Selective Card Activation Platform, Rong Guo

Yale Graduate School of Arts and Sciences Dissertations

Retinoic acid-inducible gene I (RIG-I) is a human pattern recognition receptor (PRR) that plays a key role in the innate immune response against RNA viruses, including influenza viruses, coronaviruses, and flaviviruses. As a ubiquitously expressed protein in nearly all nucleated cells, RIG-I resides primarily in the cytoplasm, where it detects foreign RNA. Although RIG-I can bind to a variety of RNA molecules, it is selectively activated by viral RNAs that have specific structural features—such as blunt-ended double-stranded regions and 5′-triphosphates. Beyond its antiviral role, RIG-I has emerged as a promising target in cancer immunotherapy, largely due to its ability to …

Identifying Quantitative Trait Loci Of Genetically Regulated Molecules To Reveal Biological Mechanisms In Complex Traits, Chen Lin

Yale Graduate School of Arts and Sciences Dissertations

Genome-wide association studies (GWAS) have identified thousands of genetic variants associated with complex traits and diseases, but most of these variants reside in non-coding regions, making their biological functions challenging to study and interpret. To investigate the potential roles of these variants, expression quantitative trait locus (eQTL) analyses associate genetic variants with gene expression, providing insights into their regulatory roles. Integrating eQTL results with GWAS summary statistics has motivated transcriptome-wide association studies (TWAS), which focus on testing associations between imputed genetically regulated gene expression (GReX) and complex traits, offering a powerful gene-level view of genetic contributions to disease. Despite substantial …

Exploration Of The Mechanisms Regulating Genomic Stability In Plants, Wenxin Yuan

Yale Graduate School of Arts and Sciences Dissertations

Genomic stability is a cornerstone of cellular integrity, with implications spanning genetic engineering, epigenetic regulation, and disease modeling. However, most studies rely on yeast or mammalian models, leaving significant gaps in our understanding of plant chromatin biology and genome stability mechanisms. Exploring the conserved and divergent processes regulating genome stability in plants has become increasingly important, especially as global climate change threatens crop yields and biodiversity. Furthermore, the developmental resilience of plants provides a unique opportunity to study genes essential in mammals, offering translational insights for agriculture and human health. This dissertation investigates the molecular and genetic mechanisms underpinning T-DNA …

Mechanistic Insights Into Respiratory Tract Susceptibility In Whim Syndrome, Yawen Jiang

Yale Graduate School of Arts and Sciences Dissertations

Warts, hypogammaglobulinemia, infections, and myelokathexis (WHIM) syndrome is a rare congenital immunodeficiency caused by gain-of-function (GOF) mutations in CXCR4. Although respiratory infections are common in WHIM patients, the underlying mechanisms of susceptibility remain unclear. Using a mouse model of WHIM syndrome, we show that myelokathexis does not impair lung immune surveillance under homeostatic conditions. During acute viral and bacterial respiratory infections, neutrophils and monocytes are efficiently recruited from circulation into the lung vasculature and parenchyma. However, these cells fail to reach the airways due to their retention in adventitial cuffs enriched with CXCL12-producing fibroblasts, where potentially function as niches typically …

Development Of Quantum Machine Learning Methods Applied To Drug Discovery, Anthony Michael Smaldone

Yale Graduate School of Arts and Sciences Dissertations

At the intersection of quantum computing and machine learning, quantum machine learning (QML) has the potential to drive major breakthroughs in chemistry and drug discovery. This dissertation explores the development of quantum neural networks and their application within drug discovery tools, navigating a deliberate path from current methodologies towards quantum enhancement under progressively more practical assumptions. Initially, we present novel Quantum Convolutional Neural Network (QCNN) architectures for multi-channel supervised learning (Chapter 2), laying the groundwork for use in a wide variety of drug discovery tasks such as protein-ligand binding affinity and structure prediction. Despite state-of-the-art performance among QCNNs on benchmark, …

Investigating The Seasonal And Interannual Evolution Of Dissolved Oxygen In The Arctic Ocean’S Canada Basin, Ashley Arroyo

Yale Graduate School of Arts and Sciences Dissertations

This dissertation examines the evolution of dissolved oxygen in the waters of the Arctic Ocean's Canada Basin. Dissolved oxygen concentrations in the ocean are initially set at the surface through air-sea exchange and subsequently modified by physical and biogeochemical processes as waters circulate and mix. The variability of dissolved oxygen in the Arctic Ocean across seasonal and interannual timescales provides valuable insight into the broader evolution of water masses in the Arctic Ocean. As dissolved oxygen concentrations are gradually depleted in deeper waters via biological consumption, and only replenished when waters return to the surface, their distribution provides a valuable …

From Individuals To Ecosystems: The Role Of Intraspecific Variation And Phenotypic Plasticity In Ecosystem Function, Nathalie Rose Sommer

Yale Graduate School of Arts and Sciences Dissertations

Understanding how organisms shape ecosystems is a central goal of ecology, particularly in an era of rapid environmental change. While ecosystem models have traditionally emphasized species-level diversity and abiotic controls, this dissertation provides evidence that trait variation within species—driven by phenotypic plasticity and transgenerational effects—can have consequences for ecosystem structure and function. Intraspecific variation is increasingly recognized as a key component of biodiversity-ecosystem function relationships, yet its effects remain underrepresented in empirical studies and predictive frameworks. By integrating multigenerational field experiments, multi-trait assessments, and detailed ecosystem measurements in a long-term, well-characterized study system, this dissertation bridges evolutionary ecology and ecosystem …

Capturing Lived Experiences Of Parents With Chronically Absent Students, Cenitra Williams

Doctor of Education Dissertations

Chronic absenteeism in K-12 public schools represents a significant national crisis, with millions of students missing 15 or more days each year. This transcendental phenomenological study investigated the lived experiences of parents whose children face chronic absenteeism, aiming to uncover the barriers and challenges that hinder consistent school attendance. Through qualitative, semi-structured interviews with parents from a small school district in upstate South Carolina, this research identified key themes related to absenteeism, including health concerns—both physical and mental—challenging morning routines, and life challenges linked to home and school environments. Findings revealed that health issues often impede the ability of students …

The Influence Of High School Teacher Perceptions Of Plcs On Eoc Scores In A Rural South Carolina School District, Marsharika M. Moody-Henegan

Doctor of Education Dissertations

This mixed methods convergent parallel study addressed high school teacher perceptions of the impact professional learning communities (PLCs) have on teaching practices and Biology I end-of-course assessment scores of students. This study is modeled after a study conducted by Dawkins (2020). Research participants in this study were science teachers from three high schools in one rural school district in South Carolina. Anonymous online teacher surveys captured quantitative data using Likert scales and qualitative data using open-response questions. Additional quantitative data were collected from a state-mandated Biology I end-of-course assessment. DuFour’s (2004) model of a PLC provided the conceptual framework, and …

Executive Function Skills Of First-Year College Students With Disabilities, Carrie Minnich

Doctor of Education Dissertations

First-year college students with disabilities face many challenges as they transition to postsecondary education. Strong executive function skills can help make the transition easier. The purpose of this mixed-methods study was to explore these students’ perceptions of their executive function skills and how they described their challenges and successes. Quantitative data were collected using the Executive Skills Questionnaire-Revised and reviewed to learn about their executive function skills. Qualitative data were collected from interview transcripts and analyzed to learn about their challenges, successes, and perspectives on their skills. Descriptive statistics indicated that students with disabilities rated most areas of executive function …

Exploring Characteristics, Supports, And Barriers For Early College High School Students, Shanetta R. Waller

Doctor of Education Dissertations

The purpose of this study was threefold: to explore and describe characteristics of a successful early college high school student and early college high school supports and barriers. Two focus groups, one with early college high school graduates and one with staff, shared their perspectives on student success characteristics, supports, and barriers. Using North Carolina Department of Public Instruction’s (2023a) Portrait of a Graduate, Maslow’s (1943) Theory of Motivation, and Goleman’s (1995) Theory of Emotional Intelligence, the study led to three significant findings. First, early college high school students must be driven and motivated with a concrete plan for their …

Exploring Compassion Fatigue Among Core Subject Middle Grades Teachers: A Quantitative Study, Michelle L. Hickey

Doctor of Education Dissertations

Research has shown increased rates of attrition among K-12 teachers since 2021, with middle school teachers being the most dissatisfied. Burnout and job-related stresses are cited as the main causes of teachers leaving the classroom. Teachers experience the same or higher levels of job-related stress as nurses, doctors, EMTs, and social workers while receiving little or no training about compassion fatigue. This study examined compassion fatigue among a sample of core subject middle school teachers from one upstate South Carolina school district. An online survey, informed by a review of current literature, revealed moderate levels of compassion fatigue among the …

Ripple Effects: A Study On Organizational Turnover Within A State Education Agency, Kayce L. Cook

Doctor of Education Dissertations

This study examined employee turnover within a state-level government agency, emphasizing its impact on organizational efficiency, program continuity, and educational outcomes. Utilizing Maslow’s Hierarchy of Needs and Herzberg’s Two-Factor Theory, the study investigated the underlying causes of turnover and identified strategic solutions for improving employee retention. A mixed methods sequential explanatory design integrated quantitative survey data with qualitative insights from anonymous open-ended responses and confidential interviews, providing a comprehensive understanding of employee experiences. Findings revealed that work-life imbalance, lack of career advancement, ineffective leadership, and inadequate communication were among the drivers of turnover. Employees expressed frustration over pay inequities, limited …

123 Studies Use In The Review, Abdul-Akeem Sadiq

Faculty Scholarship and Creative Works

No abstract provided.

Study On The Interaction Between Agricultural Practices, Religious Activities, And Cultural Relics, Fengyi Zhou, Isarachai Buranaut

NAKHARA (Journal of Environmental Design and Planning)

Community participation and how socio-cultural practices in cultural landscapes affect the protection of cultural heritage and their importance in the field of heritage protection among countries in the Mekong River Basin. This is a case study based on qualitative research methods and the theoretical framework of the eco-cultural complex, which aims to explore how community groups in Jianchuan County, Yunnan Province, China, participate in the shaping and protection of the cultural landscape. The study shows that religious activities run through all stages of the agricultural cycle, and agricultural practices have a profound impact on their content and form. Religious activities …

Mixed-Use Developments And Urban Megaprojects In The Global South : A Systematic Review And Interpretation Of A Blurred Intersection, Federico Puggioni, Nij Tontisirin

NAKHARA (Journal of Environmental Design and Planning)

This article examines the intersection of two distinct strains of urban studies: mixed-use development and urban megaprojects, through a systematic review of literature. One strain focuses on integrating diverse uses and functions within a single space, known as 'mixed-use'. The other originates from the technical complexities of megaprojects adapted to architecture and urban design. The article seeks to address a gap in the literature by clarifying the conceptual yet geographical overlaps between these two strains, which often have broad, blurred boundaries; it proposes a novel framework for defining and interpreting the related literature at this conceptual intersection.

Sustainable Construction Using Aragonite Sand From Mussel Shell Biowaste : Enhancing Building Material Development, Runda Aduldejcharas

NAKHARA (Journal of Environmental Design and Planning)

This study investigates the feasibility of using aragonite sand made from Perna viridis mussel shells as a sustainable substitute for natural sand in building materials. Growing demand for natural sand has resulted in serious environmental issues, such as habitat destruction, resource depletion, and elevated greenhouse gas emissions, driven by fast urbanization and infrastructural expansion. The goal of this project is to encourage sustainable building methods, lessen environmental deterioration, and alleviate sand scarcity by turning mussel shell biowaste into aragonite sand.  X-ray diffraction (XRD), X-ray fluorescence (XRF), and scanning electron microscopy (SEM) were among the chemical and microstructural tests used to …

Dynamics Of Landscape Transformation And Governance Of Bangkok’S Urban Waterways, Wanida Numsuk

NAKHARA (Journal of Environmental Design and Planning)

This paper critically examines the shortcomings of traditional Thai institutions in urban governance focusing on Bangkok Urban Waterways (BUW) conceptualised as dynamic and essential landscape elements. Framing BUW through the lens of ‘landscape governance’, the paper explores how institutional practices and management actions have led to erosion of cultural heritage, ineffective flood control, and the marginalisation of local communities. The research asks: To what extent does the governance of BUW contribute to these changing landscapes? To do this, the paper draws on extensive qualitative fieldwork, including interviews with government agencies, experts, practitioners, NGOs, and in-depth fieldwork with residents. The findings …

Medical-Grade Honey And Standard Dressings In Burn Wound Care: Evaluating Effectiveness, Cost, And Patient Outcomes, Andrew Golonka, Chloe Shin

Nursing | Senior Theses

Background: Burn injuries burden the healthcare system globally as silver sulfadiazine (SSD) is the standard treatment even though it delays healing and is highly costly. Medical-grade honey (MGH) demonstrates superior antimicrobial and anti-inflammatory properties, however, there are still evidence gaps when comparing effectiveness, cost efficiency, and patient centered outcomes. Purpose: This study aims to compare MGH and SSD amongst these gaps to inform evidence based burn care. Methods:A randomized controlled trial will enroll 100 people between 25-50 years of age with first and second degree burns, < 20% total body surface area within two hospital burn units. Participants will be assigned to either MGH or SSD treatment. The study will be a single blind design where dermatologists evaluating the wound photographs will not know the treatment given. Primary outcomes include wound healing time, infection rates, and patient reported pain scores. Secondary outcomes will focus on cost effectiveness analyses and patient quality of life. Standardized protocols will be implemented for data collection, wound assessment, and safety monitoring. Results: We anticipate that MGH will have lower infection rates, promote faster wound …

Education On The Early Recognition Of Antepartum Sepsis For Labor And Delivery Nurses, Diana Egan

Nursing | Senior Theses

Even though rare in occurrence, sepsis in pregnancy causes high morbidity and mortality rates, most deaths preventable with timely recognition and intervention. With symptoms difficult to identify, adjusted screening tools were created. The literature review highlighted the importance of using approaches such as these tools to improve on maternal outcomes and treatment. The review displayed how nurses in other departments find difficulty defining and identifying sepsis in adults as well as education surrounding interventions in maternal sepsis and obstetrical emergencies improve knowledge deficits. In response, questions emerge about what labor and delivery nurses know about recognizing sepsis in the pregnant …

Optimizing Discharge Education For Patients With Heart Failure, Connie-Rose Pangan

Nursing | Senior Theses

Noncompliance can be a result of a lack of comprehension of discharge instructions and a lack of concise, effective educational resources. Due to this deficit, patients with heart failure are less likely to comply with their discharge protocol and are therefore more likely to be readmitted to the hospital. The aim of the study is to consolidate a teaching method that accommodates one's existing educational barriers, implement follow-up to increase knowledge retention and improve self care, and prevent readmission among HF patients. Two hundred hospitalized, English-speaking patients with heart failure above 65 years old across 20 US Hospitals will be …

Understanding Avoidant Restrictive Food Intake Disorder (Arfid) In Autistic Children Through Parent’S Lens, Lisette Oviedo

Nursing | Senior Theses

This research reviews and proposes a study to assess parents' knowledge about their children with a dual diagnosis of autism and Avoidant-Restrictive Food Intake Disorder (ARFID) with the intent to develop future care strategies that are both person-centered and family-centered.

The Impact Of Sleep Deprivation On Maternal Decision-Making And Risk-Taking Behavior, Stephanie Marea B. Martinez

Nursing | Senior Theses

Purpose

The purpose of this research proposal aims to explore the impact of sleep education in new mothers and their ability to manage sleep deprivation with interventions during the postpartum period.

Methods

This research proposal includes various methods to evaluate the effectiveness of sleep education and mental health screenings in new mothers. The baseline data for sleep quality, postpartum depression, and the new adaptation to motherhood will be collected using the Edinburgh Postnatal Depression Scale, actigraphy to monitor sleep patterns, and a conduction of cognitive functioning with the Mini-Mental State Examination. After interventions are put into place, follow up data …

Inclusive Teaching: Strategies For Promoting Equity In The College Classroom, Kara E. Martin

Growth: The Journal of the Association for Christians in Student Development

No abstract provided.

Seeking Safety And Losing The Self: Affirmative Action Bans And The Whitening Of Mexican American Identity, Bella Bennett

Indiana Journal of Law and Social Equality

No abstract provided.

Bibliography Of Scholarship From 2025, University Of San Diego

Annual Bibliography of USD Scholarship

No abstract provided.

Review: The Shape Of Power: Stories Of Race And American Sculpture, Jiaying (Gloria) Dai

Art Inquiries

The Shape of Power: Stories of Race and American Sculpture, co-curated by Karen Lemmey,

Tobias Wofford, and Grace Yasumura, ambitiously asked: How does American sculpture

intersect with the history of race in the United States?1 Positioning itself as the first major survey

exhibition of American sculpture in decades, this exhibition featured 82 sculptures created by 70

artists spanning from 1792 to 2023.

The Relevance Of Dnajb1 Protein Dimerization Against The Human Neurodegenerative Diseases, Erina Kotreli, Trang Le, Szymon Ciesielski

Dean's Leadership Council Library Research Prize

All biological functions in living organisms depend on the activity of proteins, long molecules that must twist and fold into specific shapes to become functional. A subset of proteins known as molecular chaperones is essential for maintaining cellular health by assisting other proteins in folding correctly and refolding those damaged by stress. When proteins misfold and clump together, they can form toxic aggregates linked to many neurodegenerative diseases, including Alzheimer’s disease (AD), one of the leading causes of death in the United States. In AD, these protein aggregates form organized, elongated structures referred to as amyloid-like fibrils, which damage neurons …

State Schooling Policies And Cognitive Performance Trajectories: A Natural Experiment In A National Us Cohort Of Black And White Adults, Min Hee Kim, Sze Yan Liu, Willa D. Brenowitz, Audrey R. Murchland, Thu T. Nguyen, Jennifer J. Manly, Virginia J. Howard, Marilyn D. Thomas, Tanisha Hill-Jarrett, Michael Crowe, Charles F. Murchison, M. Maria Glymour

Department of Public Health Scholarship and Creative Works

Background: Education is strongly associated with cognitive outcomes at older ages, yet the extent to which these associations reflect causal effects remains uncertain due to potential confounding. Methods: Leveraging changes in historical measures of state-level education policies as natural experiments, we estimated the effects of educational attainment on cognitive performance over 10 years in 20,248 non-Hispanic Black and non-Hispanic White participants, aged 45+ in the Reasons for Geographic and Racial Disparities in Stroke cohort (2003-2020) by (1) using state- and year-specific compulsory schooling laws, school-term length, attendance rate, and student-teacher ratio policies to predict educational attainment for US Census microsample …

Pseudoachondroplasia, A Case Report (Preprint), Alec J. Pupo, Connor J. Stinson, Autumn Dye

Internal Medicine Resident Research

No abstract available.