Digital Commons Network^™

Diclofenac: A Review On Its Synthesis, Mechanism Of Action, Pharmacokinetics, Prospect And Environmental Impact, Hind A. Satar, Emad Yousif, Ahmed Ahmed

Al-Mustaqbal Journal of Pharmaceutical and Medical Sciences

Diclofenac, potent a nonsteroidal anti-inflammatory drug, used in the treatment of inflammation, pain and fever associated with a wide range of disease condition. This review article focuses the synthesis, mechanism of action, pharmacokinetics and derivatives of diclofenac and also highlights advances in the possible use of diclofenac in treating other condition outside its current clinical therapeutic use as an analgesic, anti-inflammatory and antipyretic agent as well the prospect of drug repurposing of diclofenac for treatment of disease like cancer. It further highlights the adverse effect of the drug as an emerging contaminant in the environment. Diclofenac acts by inhibition of …

Rhythm Machine: Polyrhythmic Dimensions, James Elam

Theses and Dissertations

James Elam combines visual and aural mediums with technology to capture and manipulate sound. Here, Elam discusses how the repetitive elements in his work serve a practical purpose and add a conceptual and tactile layer to his sculptures and echo the hypnotic qualities in his DJ practice.

Development Of Interface-Specific Two-Dimensional Vibrational-Electronic (I2d-Ve) Spectroscopy For Vibronic Couplings At Interfaces, Yuqin Qian, Zhi-Chao Huang-Fu, Jesse B. Brown, Yi Rao

Chemistry and Biochemistry Faculty Publications

Bulk 2D electronic–vibrational (2D-EV) and 2D vibrational–electronic spectroscopies (2D-VE) were previously developed to correlate the electronic and vibrational degrees of freedom simultaneously, which allow for the study of couplings between electronic and vibrational transitions in photo-chemical systems. Such bulk-dominated methods have been used to extensively study molecular systems, providing unique information such as coherence sensitivity, molecular configurations, enhanced resolution, and correlated states and their dynamics. However, the analogy of interfacial 2D spectroscopy has fallen behind. Our recent work presented interface-specific 2D-EV spectroscopy (i2D-EV). In this work, we develop interface-specific two-dimensional vibrational–electronic spectroscopy (i2D-VE). The fourth-order spectroscopy is based on a …

Spatiotemporal Synchrony Of Climate And Fire Occurrence Across North American Forests (1750–1880), Ellis Margolis, Andreas Wion, John Abatzoglou, Lori Daniels, Donald Falk, Chris Guiterman, James Johnston, Kurt Kipfmueller, Charles Lafon, Rachel Loehman, Maggie Lonergan, Cameron Naficy, Marc-André Parisien, Sean Parks, Jeanne Portier, Michael Stambaugh, Ellen Whitman, A. Park Williams, Larissa Yocom

Wildland Resources Faculty Publications

Aim: Increasing aridity has driven widespread synchronous fire occurrence in recent decades across North America. The lack of historical (pre-1880) fire records limits our ability to understand long-term continental fire-climate dynamics. The goal of this study is to use tree-ring reconstructions to determine the relationships between spatiotemporal patterns in historical climate and widespread fire occurrence in North American forests, and whether they are stable through time. This information will address a major knowledge gap required to inform projections of future fire.

Location: North American Forests.

Time Period: 1750–1880 CE.

Major Taxa Studied: Trees.

Methods: We applied regionalisation methods to tree-ring …

Prediction Of Vessel Arrival Time To Optimize Berth Allocation In Ports Using Machine Learning Methods, Anfal Mansour Albloushi

Theses

80% of the world trade is carried out through the sea, which shows the importance of maintaining transportation efficiency in the maritime industry. The vessel arrival time and berth allocation pose a significant challenge in the marine field's day-to-day operation, especially when a high number of vessels are waiting at the anchorage to deliver the goods on time. This increases the pressure on the responsible stakeholders and good owners as some cargo must be delivered urgently. Artificial intelligence and machine learning play a vital role in improving the operation of different fields; utilizing such technologies in the maritime industry will …

Resurrection In The Regensburg Pendant: Materials And Iconography, Devotional Object As Sacred Jewelry, Margarita Benacerraf

Theses and Dissertations

The Regensburg butterfly (1310-1320), an exquisitely crafted reliquary pendant, was found in the head of a fourteenth-century crucifix in 1991. The locket’s butterfly shape—and the ways in which the butterfly serves as a metaphor for Christ’s redemption—remains a fascinating window into late medieval Christianity and devotional practices in the medieval world.

Identifying Personality In Reptiles And Assessing Welfare Implications For Their Roles As Ambassador Animals In An Educational Setting, Valery Gonzalez

Theses and Dissertations

This study examined behavioral variability and personality in 13 reptiles used as ambassador animals at the American Museum of Natural History. Observations across seasons and novel object tests revealed individual differences, behavioral components, and correlations. Findings emphasize reptilian complexity, highlighting welfare implications while underscoring the need for further research.

Examining Risk Factors For Comorbidity Between Posttraumatic Stress Disorder And Obsessive-Compulsive Disorder In A Sample Of Trauma-Exposed Transgender Adults, Dylan Seeley

Theses and Dissertations

Comorbid PTSD-OCD post trauma exposure is understudied. Little research examines specific risk factors and marginalized populations. This study examined gender-based victimization, emotional avoidance, and executive functioning as risk factors. Findings suggest gender-based victimization is a unique gender minority stressor that may pose significant risk for transgender populations.

Using Spatial Network Analysis To Explore Migration Of Extended Families In Historical Research, Rock Miller

Theses and Dissertations

This project proposes a geoinformatics approach for understanding the migration of extended families in historical contexts. It uses full-count longitudinal census data (developed by the Minnesota Population Center) and graph methods to define multi-generational extended family relationships and to model the locational structures of these families as a spatial network. Graph algorithms and mapping methods are used to interrogate these structures as reflections of the patterns of family outmigration and extension over time. The study is based on a set of extended families resident in a 15-county study area in the Bluegrass region of Kentucky in 1870, and their evolution …

Forest Above-Ground Biomass Estimation Using Nasa Gedi Lidar Waveforms And Global Tree Allometry, Ian Grant

Theses and Dissertations

Above-ground forest biomass plays a crucial role in global carbon cycles, yet accurately estimating biomass at global scales remains challenging. This thesis addresses two key challenges in processing NASA’s Global Ecosystem Dynamics Investigation (GEDI) space-borne lidar data to estimate above-ground biomass density (AGBD): accounting for global variation in forest structure and developing robust physical interpretations of lidar returns. The first component of the thesis analyzes global patterns of tree allometry using the Tallo tree allometry dataset, examining relationships between tree dimensions across biomes, continents, and plant functional types. This analysis reveals consistent allometry across continents for some biomes (e.g., tropical …

Free Fall, Mariam Bolkvadze

Theses and Dissertations

Free Fall, a mixed media project, addresses the horrifying cases of infant abduction experienced in the country of Georgia over the last 40-50 years, and how the nation's systemic issue became one of the causes of illegal child trafficking in the country. The project features an infant room setting with video projections, TV screens with interviews, and custom sound effects. The setting of Free Fall is a visual metaphor of the experiences of those affected by the abductions and illegal child trafficking drawing from the iconography of early childhood. Ultimately, my installation seeks to advocate for justice and support …

Social Networks And Behavioral Adaptation Of Serrano Horses In A Rewilding Initiative In Spain, Ashley Bruno

Theses and Dissertations

Rewilding is a conservation measure that involves actively relocating species or restricting human land use to improve ecosystem sustainability. However, critics raise concerns that rewilding privileges ecosystem function over endangered species. Due to a lack of monitoring around species’ relocations, uncertainty lies in ecological outcomes and psychological, social, cultural impacts on affected animals. For this project, we collaborated with the non-profit Rewilding Europe that sought to conserve Serrano horses (Equus caballus), an ancient and under-studied breed of Spanish horse by relocating 11 individuals to a protected site in Guadalajara, Spain in June 2022. Our research aimed to address …

Land Use Change Consistently Reduces Α- But Not Β- And Γ-Diversity Of Bees., Toby P N Tsang, A A Amado De Santis, Gabriela Armas-Quiñonez, John S Ascher, Eva Samanta Ávila-Gómez, András Báldi, Kimberly M Ballare, Mario V Balzan, Weronika Banaszak-Cibicka, Svenja Bänsch, Yves Basset, Adam J Bates, Jessica M Baumann, Mariana Beal-Neves, Ashley Bennett, Antonio Diego M Bezerra, Betina Blochtein, Riccardo Bommarco, Berry Brosi, Laura A Burkle, Luísa G Carvalheiro, Ignacio Castellanos, Marcela Cely-Santos, Hamutahl Cohen, Drissa Coulibaly, Saul A Cunningham, Sarah Cusser, Isabelle Dajoz, Deborah A Delaney, Ek Del-Val, Monika Egerer, Markus P Eichhorn, Eunice Enríquez, Martin H Entling, Natalia Escobedo-Kenefic, Pedro Maria Abreu Ferreira, Gordon Fitch, Jessica R K Forrest, Valérie Fournier, Robert Fowler, Breno M Freitas, Hannah R Gaines-Day, Benoît Geslin, Jaboury Ghazoul, Paul Glaum, Jose L Gonzalez-Andujar, Adrian González-Chaves, Heather Grab, Claudio Gratton, Solène Guenat, Catalina Gutiérrez-Chacón, Mark A Hall, Mick E Hanley, Annika Hass, Ernest Ireneusz Hennig, Martin Hermy, Juliana Hipólito, Andrea Holzschuh, Sebastian Hopfenmüller, Keng-Lou James Hung, Kristoffer Hylander, Jordi Izquierdo, Mary A Jamieson, Birgit Jauker, Steve Javorek, Shalene Jha, Björn K Klatt, David Kleijn, Alexandra-Maria Klein, Anikó Kovács-Hostyánszki, Jochen Krauss, Michael Kuhlmann, Patricia Landaverde-González, Tanya Latty, Misha Leong, Susannah B Lerman, Yunhui Liu, Ana Carolina Pereira Machado, Anson Main, Rachel Mallinger, Yael Mandelik, Bruno Ferreira Marques, Kevin Matteson, Frédéric Mccune, Ling-Zeng Meng, Jean Paul Metzger, Paula María Montoya-Pfeiffer, Carolina Morales, Lora Morandin, Jane Morrison, Sonja Mudri-Stojnić, Pakorn Nalinrachatakan, Olivia Norfolk, Mark Otieno, Mia G Park, Stacy M Philpott, Gideon Pisanty, Montserrat Plascencia, Simon G Potts, Eileen F Power, Kit Prendergast, Robyn D Quistberg, Davi De Lacerda Ramos, André Rodrigo Rech, Victoria Reynolds, Miriam H Richards, Stuart P M Roberts, Malena Sabatino, Ulrika Samnegård, Hillary Sardiñas, Karina Sánchez-Echeverría, Fernanda Teixeira Saturni, Jeroen Scheper, Amber R Sciligo, C Sheena Sidhu, Brian J Spiesman, Tuanjit Sritongchuay, Ingolf Steffan-Dewenter, Katharina Stein, Alyssa B Stewart, Jane C Stout, Hisatomo Taki, Pornpimon Tangtorwongsakul, Caragh G Threlfall, Carla Faleiro Tinoco, Teja Tscharntke, Katherine J Turo, Chatura Vaidya, Rémy Vandame, Carlos H Vergara, Blandina F Viana, Eric Vides-Borrell, Natapot Warrit, Elisabeth Webb, Catrin Westphal, Jennifer B Wickens, Neal M Williams, Nicholas S G Williams, Caleb J Wilson, Panlong Wu, Elsa Youngsteadt, Yi Zou, Lauren C Ponisio, Timothy C Bonebrake

Entomology Faculty Publications

Land use change threatens global biodiversity and compromises ecosystem functions, including pollination and food production. Reduced taxonomic α-diversity is often reported under land use change, yet the impacts could be different at larger spatial scales (i.e., γ-diversity), either due to reduced β-diversity amplifying diversity loss or increased β-diversity dampening diversity loss. Additionally, studies often focus on taxonomic diversity, while other important biodiversity components, including phylogenetic diversity, can exhibit differential responses. Here, we evaluated how agricultural and urban land use alters the taxonomic and phylogenetic α-, β-, and γ-diversity of an important pollinator taxon-bees. Using a multicontinental dataset of 3117 bee …

Chronic Heavy Alcohol Intake And Liver-Specific Lrp-1 Reduction Increase Amyloidosis In Alzheimer’S Disease Mice, Devaraj V. Chandrashekar, G. Chuli Roules, Ross A. Steinberg, Urvashi R. Panchal, Nataraj Jagadeesan, Adenike Oyegbesan, Trinh Roselyn, Joshua Yang, Sharda R. Bhagwat, Hiya Rakholia, Rutvi D. Mevawala, Moom Roosan, Derick Han, Rachita K. Sumbria

Pharmacy Faculty Articles and Research

Background

Chronic heavy alcohol drinking may be a modifiable risk factor for Alzheimer’s disease (AD), but studies in rodent AD models more closely mimic chronic moderate alcohol drinking in humans and largely focus on the brain. The role of the liver, which is significantly impacted by chronic heavy alcohol intake, in driving brain changes in alcohol-dependent AD remains unexplored. Our study using intragastric-ethanol feeding, which mimics chronic heavy alcohol intake in humans, in C57BL/6J mice showed significant AD-relevant changes in the brain and liver. Therefore, we aimed to investigate how hepatic changes using this model of chronic heavy drinking drive …

Center For The Humanities Supports Trio Of Faculty Research Fellows, Katie Umans

UNH Today Archive

No abstract provided.

Multilevel Peatland Governance: Exploring The Policy Impact Among Local Actors In Shaping Peatland Policy Intervention In Indonesia, Alfajri Alfajri, Helena Varkkey, Patrick O'Reilly, Tengku Adeline Adura

Forest and Society

Indonesia established the Peatland Restoration Agency (BRG, now BRGM) in 2016 to address land and forest fire issues through measures to develop and strengthen the implementation of policies to restore some part of the 24 million hectares of the country's damaged peatlands. BRGM was presented as a response to the transboundary haze issue and was applauded globally, with substantial success claimed in delivering changes in local land management behaviours. However, limited detailed analyses have been conducted regarding how the BRGM programme is implemented. Employing concepts drawn from work exploring multilevel governance strategies and actor-network theory (ANT), we explore how the …

Medicinal Plant Production System Management In Rural Java, Indonesia: Views Of Local Actors From A Participatory Rural Appraisal Approach, Sri Astutik, Vianny Ahimbisibwe, Kendisha Soekardjo Hintz, Purwanto Purwanto, Muhammad Alie Humaedi

Forest and Society

Medicinal plants’ production systems in Indonesia’s rural Java play a crucial role in sustaining local livelihoods and healthcare needs. Medicinal plants are managed by locals independently based on household preferences and endowments through wild gathering and cultivation-based production systems. However, these situations create a continual problem of weak bargaining positions. Thus, this study aimed to assess local needs and potential in supporting medicinal plants production systems management in Java, Indonesia, with the view to advance local actors' perspectives in a multistakeholder platform. The Participatory Rural Appraisal (PRA) approach proved useful in incorporating local knowledge in the planning and development of …

Michal’S Legacy: Bridging Biblical Narratives With Advocacy For Women, Rodel D. Magin

Landas

This article explores biblical narratives, focusing specifically on Michal’s story from the books of Samuel (1 Sam 14:19, 18:20-28, 19:11-17, 25:44, 2 Sam 3:12- 16, and 6:16-23), the daughter of King Saul who became David's wife, to shed light on women’s challenges. Through narrative analysis and feminist interpretation, it highlights the relevance of Michal’s story in addressing contemporary societal issues. By drawing on insights from these narratives, the study advocates for societal transformation and gender equality, emphasizing the urgent need for action to alleviate the struggles women face. As the Church upholds the dignity of every individual, regardless of their …

Accelerating Biosimilar Market Access: The Case For Allowing Earlier Standing, S. Sean Tu, Rachel Goode, Matthew Turner, Victor Van De Wiele

Law Faculty Scholarship

Biosimilars, which are affordable alternatives to biologic medicines, face delays in market entry due to the current patent litigation framework under the Biologic Price Competition and Innovation Act. Currently, biosimilar manufacturers can only initiate patent litigation to attempt to clear weak and invalid patents after submitting their Biologic License Application to the Food and Drug Administration (FDA), which happens after completing extensive, and costly clinical trials. By contrast, generic drug manufacturers can start litigation earlier due to shorter development times and less stringent clinical requirements, allowing them to launch immediately after the primary patent expires. We propose allowing biosimilars to …

Pathogen And Host Associations Of Soft Ticks Collected In South Texas, Sarah E. Mays Maestas, Lauren P. Maestas, Phillip E. Kaufman

School of Integrative Biological & Chemical Sciences Faculty Publications

Background: Soft ticks (Family: Argasidae) are vectors of relapsing fever Borrelia in the United States and are potential vectors of African swine fever virus, a pathogen that could have a devastating effect on the U.S. swine industry if introduced to the U.S. mainland. Much of the tick-borne disease research in the U.S. focuses on hard ticks, and less is known about the ecology of soft ticks. Some soft tick species found in the southern U.S. have a wide host range and may feed on cattle, swine, native and exotic ungulates, small mammals, reptiles, and humans. Because the feeding habit of …

Mate-Pair Sequencing Enables Identification And Delineation Of Balanced And Unbalanced Structural Variants In Prenatal Cytogenomic Diagnostics, Jicheng Qian, Huilin Wang, Hailei Liang, Yuting Zheng, Mingyang Yu, Wing Ting Tse, Angel Hoi Wan Kwan, Lo Wong, Natalie Kwun Long Wong, Isabella Yi Man Wah, So Ling Lau, Shuk Yi Annie Hui, Matthew Hoi Kin Chau, Xiaoyan Chen, Rui Zhang, Liona C Poon, Tak Yeung Leung, Pengfei Liu, Kwong Wai Choy, Zirui Dong

Faculty, Staff and Students Publications

Background: Mate-pair sequencing detects both balanced and unbalanced structural variants (SVs) and simultaneously informs in relation to both genomic location and orientation of SVs for enhanced variant classification and clinical interpretation, while chromosomal microarray analysis (CMA) only reports deletion/duplication. Herein, we evaluated its diagnostic utility in a prospective back-to-back prenatal comparative study with CMA.

Methods: From October 2021 to September 2023, 426 fetuses with ultrasound anomalies were prospectively recruited for mate-pair sequencing and CMA in parallel for prenatal genetic diagnosis. Balanced/unbalanced SVs and regions with absence of heterozygosity (AOH) were detected and classified independently, and comparisons were made between mate-pair …

Genomic Data And Privacy, Candace T Myers, Runjun D Kumar, Lisa Pilgram, Luca Bonomi, Mara Thomas, Obi L Griffith, Stephanie M Fullerton, Richard A Gibbs

Faculty, Staff and Students Publications

No abstract provided.

Sigma Gamma Epsilon Student Research Poster Session, Geological Society Of America Connects 2024, Anaheim, California, Usa, Scott R. Beason, Lee S. Potter

The Compass: Earth Science Journal of Sigma Gamma Epsilon

The Society of Sigma Gamma Epsilon sponsors a poster session at every annual meeting of the Geological Society of America. The 36th Sigma Gamma Epsilon undergraduate research poster session took place during the 2024 Geological Society of America Annual Meeting (GSA Connects) in Anaheim, California, USA, on Monday, September 23, 2024. Twenty-eight (28) posters were presented in Exhibit Hall D at the Anaheim Convention Center between 8:00 AM and 5:30 PM at the poster session. Titles, authors (italics for the presenting author), affiliations, and abstracts for each poster are listed in this report. Additionally, winners of the Austin A. Sartin …

The Compass - Volume 94 Issue 1 - Complete Issue, Scott R. Beason

The Compass: Earth Science Journal of Sigma Gamma Epsilon

No abstract provided.

Waves Of Bugis Migration To The Mahakam Delta: Livelihood Trajectories And Landscape Changes Along The Rural Coastlines Of East Kalimantan, Muh. Ilham Basmar, Nurhady Sirimorok, Karno B. Batiran, Fatwa Faturachmat, Andi Sadapotto, Muhammad Alif K. Sahide, Micah R. Fisher

Forest and Society

This article describes an often overlooked dimension of land use change, namely the extent to which migration affects livelihoods and landscapes in destination areas. We concentrate on the long history of migration of Bugis from South Sulawesi province to the Mahakam Delta on the east coast of Kalimantan, which has taken place over hundreds of years. To understand this migration pattern, we first delve into the dynamics of Bugis mobility across the Sulawesi Strait by examining the push and pull factors that reshape the Mahakam Delta. We then examine the livelihood trajectories of the migrants, their political economic contexts in …

Reviewing Mangrove Degradation, Conservation, And Restoration: A Sustainability Nexus Assessment On Myanmar Using The Dpsir Framework, Lwin Thuzar Nyein, Daniel Karthe, Lukas Giessen, Mukand Singh Babel, Carsten Schusser

Forest and Society

Mangrove forests are vital for supporting local livelihoods and are an integral component of coastal ecosystems in Myanmar. However, they continue to degrade or even disappear across the country’s coastal regions even though rehabilitation processes have been initiated in several regions. Still, little research and systematic inquiry into the drivers of mangrove degradation in Myanmar is available. Against this background, this study identifies the primary forces affecting the mangrove ecosystem and the challenges for mangrove conservation in Myanmar by combining a systematic literature review (SLR) on mangrove change with the Driver-Pressure-State-Impact-Response (DPSIR) analytical framework. We find economic activities, predominantly in …

The Illegal Online Trade Of Indonesian Protected Pitcher Plants, Uswatun Hasanah, Retno Utami, Yatha Maziyyatul Hijriyah, Eni Nuraeni, Dwi Hilda Putri, Syahrul Kurniawan, Iyan Robiansyah

Forest and Society

Indonesia is a global hotspot of pitcher plant diversity with 80 Nepenthes species recorded to date - 59 protected under Indonesian law - and more species likely to be discovered and described in the future. Under Indonesian law, these protected Nepenthes can only be traded if they originate from artificially propagated sources, and trade necessitates specific permits and government-issued certification. The present study aimed to evaluate the trade of Nepenthes species protected by Indonesian law in Indonesian-language online markets. The trade data was searched in March 2024 in the top five most visited e-commerce in Indonesia, i.e., Shopee, Tokopedia, Lazada, …

Militarization Of Anti-Peasant Forest Conservation: The Case Of The Amazon Forest Reserve Zone (Afrz) After The Colombian 2016 Peace Agreement, Angie L. Durán, Luz A. Rodríguez

Forest and Society

In 2016, the Colombian government signed a peace agreement with the Fuerzas Armadas Revolucionarias de Colombia (FARC) that included the implementation of a Comprehensive Rural Reform (CRR) with the purpose to allocate and formalize land for peasant populations. In parallel, Colombia was committed to implement the global environmental agendas, including efforts to mitigate greenhouse gas emissions (GHG) by reducing deforestation in the Amazon. Campesino communities in Colombia have historically been marginalized and pushed into forested lands and protected areas. This study seeks to understand the configuration of land-use conflicts in the Amazon Forest Reserve Zone (AFRZ) - a land management …

Rethinking The Rise Of Early-Onset Gastrointestinal Cancers: A Call To Action, Benjamin A Weinberg, Caitlin C Murphy, David R Freyer, K Leigh Greathouse, Jan K Blancato, Elena M Stoffel, Julia L Drewes, Anne Blaes, John M Salsman, Y Nancy You, Hannah Arem, Reetu Mukherji, Priyanka Kanth, Xin Hu, Anne Fabrizio, Marion L Hartley, Marios Giannakis, John L Marshall

Faculty, Staff and Student Publications

Since the early 1990s, there has been a dramatic rise in gastrointestinal cancers diagnosed in patients under age 50 for reasons that remain poorly understood. The most significant change has been the increase in incidence rates of early-onset colorectal cancer, especially rates of left-sided colon and rectal cancers. Increases in gastric, pancreatic, and other gastrointestinal cancer diagnoses have further contributed to this trend. We formed a multidisciplinary Think Tank to develop a strategic, coordinated approach to studying early-onset gastrointestinal cancers. This area of research is challenging given multifactorial etiologies. We focused on epidemiology and the environment, the microbiome, and survivorship …

Comprehensive Characterization Of The Transcriptional Landscape In Alzheimer’S Disease (Ad) Brains, Chengxuan Chen, Zhao Zhang, Yuan Liu, Wei Hong, Hande Karahan, Jun Wang, Wenbo Li, Lixia Diao, Meichen Yu, Andrew J Saykin, Kwangsik Nho, Jungsu Kim, Leng Han

Faculty, Staff and Student Publications

Alzheimer's disease (AD) is the leading dementia among the elderly with complex origins. Despite extensive investigation into the AD-associated protein-coding genes, the involvement of noncoding RNAs (ncRNAs) and posttranscriptional modification (PTM) in AD pathogenesis remains unclear. Here, we comprehensively characterized the landscape of ncRNAs and PTM events in 1460 samples across six brain regions sourced from the Mount Sinai/JJ Peters VA Medical Center Brain Bank Study and Mayo cohorts, encompassing 33,321 long ncRNAs, 92,897 enhancer RNAs, 53,763 alternative polyadenylation events, and 900,221 A-to-I RNA editing events. We additionally identified 25,351 aberrantly expressed ncRNAs and altered PTM events associated with AD …