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Tcas Benchmark, Vol. 4, No. 9, 2005, Glynn Osburn, Paula Vastine

North Texas Archeological Society Records

Volume four and issue nine of TCAS Benchmark.

Tcas Benchmark, Vol. 4, No. 8, 2005, Glynn Osburn, Paula Vastine, Nathan Hays, Deborah Bloys Hardin, Martha Spalding

North Texas Archeological Society Records

Volume four and issue eight of TCAS Benchmark.

Tcas Benchmark, Vol. 4, No. 5. 2005, Color Copy, Glynn Osburn, Paula Vastine, Alan Skinner

North Texas Archeological Society Records

Color copy of volume four and issue five of TCAS Benchmark, with last few pages missing.

Tcas Benchmark, Vol. 4, No. 2, 2005, Glynn Osburn, Paula Vastine

North Texas Archeological Society Records

Volume four and issue two of TCAS Benchmark.

Tcas Benchmark, Vol. 3, No. 1, 2005, Glynn Osburn, Paula Vastine

North Texas Archeological Society Records

Volume three and issue one of TCAS Benchmark.

Evaluation Of Green Tea Yoghurt Enriched With Lacticaseibacillus Paracasei E1 Microcapsules On Macrophage M1 Profile In High Fat-Fructose Diet Mice, Esha Ardiansyah, Nur Alfi Maghfirotus Sa’Adah, Rahmi Izati, Belinda Nabiila Al Faizah, Dawama Nur Fadlilah, Septhyanti Aprilia Kavitarna, Mochammad Fitri Atho’Illah, Siti Nur Arifah, Yoga Dwi Jatmiko, Muhaimin Rifa’I

Karbala International Journal of Modern Science

Obesity is caused by an energy imbalance that increases chronic low-grade inflammation, including macrophage cell infiltration. Adipose tissue macrophages are polarized into pro-inflammatory macrophage type 1 (M1), secrete large amounts of pro-inflammatory cytokines, and activate transcription factors. Yoghurt with probiotics is popular at all ages for its health benefits and must be protected by microencapsulation. Green tea (Camellia sinensis L.) fortification provides yoghurt nutrients while improving its functional qualities and bioactivity. This study aimed to evaluate the effect of microencapsulation of Lacticaseibacillus paracasei E1 in green tea yoghurt (GTY) on the profile of M1 macrophages in mice fed a …

Faculty Senate Monthly Packet January 2025, Portland State University Faculty Senate

Faculty Senate Monthly Packets

The January 6, 2025 monthly packet includes the agenda, appendices, and the Faculty Senate minutes and attachments from the meeting held January 6, 2025.

Lanthorn, Vol. 59, No. 09, January 6, 2025, Grand Valley State University

Volume 59, August 5, 2024 – April 14, 2025

Lanthorn is Grand Valley State's student newspaper, published from 1968 to the present.

The Wright Brothers And Their Genetic Susceptibility To Typhoid Fever, John D. Bullock, H Bradford Hawley

Population and Public Health Sciences Faculty Publications

Importance: Typhoid fever gravely sickened Orville Wright in 1896 and the disease killed his older brother, Wilbur, in 1912. The occurrence of typhoid fever among other Wright family members has never been explored.

Objective: To investigate the number of cases of typhoid fever in the Wright brothers’ family and determine if they had a predisposition to typhoid fever that might have had a genetic basis.

Methods: Biographical information concerning the Wright brothers was examined and a family tree was constructed. Using an estimated untreated case fatality rate of 20%, typhoid fever mortality data from decennial U.S. censuses (1850-1920) was converted …

Structured Staff Education On Incorporating Social Determinants Of Health Into Phq-9 Depression Screening For Improved Patient Outcomes, Gbemisola Elizabeth Mojelope

Walden Dissertations and Doctoral Studies

This doctor of nursing (DNP) project addressed a significant practice gap in an outpatient community healthcare setting, where staff lacked knowledge related to patient health questionnaire (PHQ-9) depression screening. The project’s focus question addressed whether staff education increased knowledge pertaining to the PHQ-9 depression screening. The initiative aimed to equip healthcare providers with the skills needed to incorporate social determinants of health in routine depression screenings, enhancing early identification of depressive symptoms and supporting targeted interventions. Fifteen healthcare workers voluntarily participated in the education. The in-person education initiative highlighted the importance of integrating social determinants of health (SDoH) into PHQ-9 …

Ada News - 01/06/2025, American Dental Association, Publishing Division

ADA News

Established in 1970 as the official newspaper of the American Dental Association, the ADA News serves practicing dentists and others allied to the dental profession in the U.S. and internationally. It is the No. 1 source of news and information about the many benefits and services the ADA delivers to members daily as well as timely information on scientific, social, political and economic developments affecting dentistry and health care.

Intouch Week Of January 6, 2025, New York Medical College

InTouch

• Celebrating the Best of 2024
• What Matters Most to Medical School Admissions Staff
• SHSP Adds Two Joint Degree Programs: Psy.D./M.P.H. and D.O./M.P.H.
• Pregnant Women with Pulmonary Arterial Hypertension Can Deliver Safely with Careful Management
• Love at NYMC

Emerging Ai Approaches For Cancer Spatial Omics., Javad Noorbakhsh, Ali Foroughi Pour, Jeffrey Chuang

Faculty Research 2025

Technological breakthroughs in spatial omics and artificial intelligence (AI) have the potential to transform the understanding of cancer cells and the tumor microenvironment. Here we review the role of AI in spatial omics, discussing the current state-of-the-art and further needs to decipher cancer biology from large-scale spatial tissue data. An overarching challenge is the development of interpretable spatial AI models, an activity that demands not only improved data integration but also new conceptual frameworks. We discuss emerging paradigms-in particular, data-driven spatial AI, constraint-based spatial AI, and mechanistic spatial modeling-as well as the importance of integrating AI with hypothesis-driven strategies and …

Investigating The Thermodynamic Properties Of Fat10 And Fat10ylated Proteins, Aravind R

Theses and Dissertations

Degradation of proteins by the proteasome is crucial in regulating protein levels in the cell. Post-translational modifications, such as ubiquitylation and Fat10ylation, trigger proteasomal degradation of the substrate proteins. While ubiquitylation orchestrates multiple cellular processes, Fat10ylation is primarily involved in the inflammatory response. Unlike ubiquitin, recycled upon substrate degradation, Fat10 is degraded along with its substrate. Although the thermodynamic properties of the substrate are critical for effective proteasomal degradation, they remain poorly understood for the Fat10-proteasome pathway.

Here, we demonstrate that Fat10 exhibits markedly lower thermodynamic stability and faster unfolding kinetics compared to ubiquitin. This is due to the absence …

Understanding The Insecticidal Toxin Xpta2: A Shift In Toxin Complex Biology, Cole Lorenza Martin

All ETDs from UAB

Pore forming toxins (PFTs) belonging to the ABC toxin complex (Tc) family are responsible for targeting and translocating toxins into target cells. ABC toxins consist of three separate subunits, each subunit providing a vital role in the cytotoxic mechanism of the Tc. The A subunit or TcA is the largest subunit of the complex and contains the binding domains and the translocation channel that perforates the membrane. The B subunit or TcB functions as a gated linker that forms a cocoon with the TcC which houses the toxic peptide and subsequently gets translocated through the TcB and TcA into the …

Role Of Ring-Box E3 Ligases In Runx2 And Sp7 Protein Turnover During Osteoblast Differentiation, Abeera Sikandar

All ETDs from UAB

The bone matrix synthesis by osteoblast during skeletogenesis is regulated by several transcription factors and signaling pathways. Runx2 and Sp7 are master regulators of osteoblast differentiation and bone formation. Deletion of both genes in mice results in the complete failure of ossification. In humans, Sp7 and Runx2 genes mutations cause osteogenesis imperfecta and cleidocranial dysplasia, respectively. The progression of osteoblast differentiation requires a coordinated and temporal expression of Runx2 and Sp7 genes. Posttranslational modifications regulate the cellular levels and function of Runx2 and Sp7 proteins. Ubiquitination controls protein turnover through targeted degradation. The multi-subunit SCF-complex is the largest class of …

Monitoring And Assessment Of Population, Reproductive, And Health Effects In Colonial Waterbirds Breeding At Contaminated Great Lakes Sites In Michigan, Keith A. Grasman, Mandy Annis, Carly Eakin, Jeremy Moore, Lisa L. Williams

University Faculty Publications and Creative Works

Immunological, reproductive, and population endpoints were assessed in fish-eating birds during 2010–2019 in the Saginaw River and Bay and River Raisin Areas of Concern (AOCs) and Grand Traverse Bay, which are ecosystems historically contaminated with polychlorinated biphenyls, dibenzo-p-dioxins, and dibenzofurans. Reference sites were in the lower St. Marys River (herring gulls and Caspian terns), eastern Lake Superior (terns), and eastern Lake Huron (black-crowned night herons). Relative risk ratios for embryonic nonviability (from both infertility and mortality) in gull embryos were 2–3-fold higher than the reference site in both AOCs and Grand Traverse Bay. Twelve of 13 deformed embryos and chicks …

Metal-Rich Lacustrine Sediments From Legacy Mining Perpetuate Copper Exposure To Aquatic-Riparian Food Webs, Brittany G. Perrotta, Karen A. Kidd, Kate M. Campbell, Marie-Noële Croteau, Tyler J. Kane, Amy Marcarelli, R Blaine Mccleskey, Gordon Paterson, Craig A. Stricker, David M. Walters

Michigan Tech Publications

Historic copper mining left a legacy of metal-rich tailings resulting in ecological impacts along and within Torch Lake, an area of concern in the Keweenaw Peninsula, Michigan, USA. Given the toxicity of copper to invertebrates, this study assessed the influence of this legacy on present day nearshore aquatic and terrestrial ecosystems. We measured the metal (Co, Cu, Ni, Zn, Cd) and metalloid (As) concentrations in sediment, pore water, surface water, larval and adult insects, and two riparian spider taxa collected from Torch Lake and a nearby reference lake. Overall, elevated metal and metalloid concentrations, particularly Cu, were measured in all …

Structured Staff Education On Incorporating Social Determinants Of Health Into Phq-9 Depression Screening For Improved Patient Outcomes, Gbemisola Elizabeth Mojelope

Walden Dissertations and Doctoral Studies

This doctor of nursing (DNP) project addressed a significant practice gap in an outpatient community healthcare setting, where staff lacked knowledge related to patient health questionnaire (PHQ-9) depression screening. The project’s focus question addressed whether staff education increased knowledge pertaining to the PHQ-9 depression screening. The initiative aimed to equip healthcare providers with the skills needed to incorporate social determinants of health in routine depression screenings, enhancing early identification of depressive symptoms and supporting targeted interventions. Fifteen healthcare workers voluntarily participated in the education. The in-person education initiative highlighted the importance of integrating social determinants of health (SDoH) into PHQ-9 …

Editorial: Unveiling The Next Generation Of Cancer Immunity & Immunotherapy, Mohanraj Sadasivam, Nethaji Muniraj, Chellappagounder Thangavel

Center for Translational Medicine Faculty Papers

No abstract provided.

Restoring The AhupuaʻA: Community-Based Resource Management And Resilience In KauaʻI, Jeffrey W. Walbridge Jr.

Environmental Studies Senior Theses

This thesis analyzes Kauaʻi’s evolving resource management practices, examining the intersections of historical governance frameworks, modern legal systems, and indigenous knowledge. Utilizing the traditional ahupuaʻa system, Kauaʻi’s approach once promoted holistic stewardship across water, land, and energy resources. However, colonial policies, corporate influence, and economic pressures have gradually shifted this framework toward a market-driven model, often prioritizing tourism and development over ecological resilience. Key policy shifts as they fight to return to an ahupua'a based model – from the Great Mahele’s introduction of private land ownership to water diversions for plantation agriculture – help examine how these changes continue to …

Scproatlas: An Atlas Of Multiplexed Single-Cell Spatial Proteomics Imaging In Human Tissues, Tiangang Wang, Xuanmin Chen, Yujuan Han, Jiahao Yi, Xi Liu, Pora Kim, Liyu Huang, Kexin Huang, Xiaobo Zhou

Faculty, Staff and Student Publications

Spatial proteomics can visualize and quantify protein expression profiles within tissues at single-cell resolution. Although spatial proteomics can only detect a limited number of proteins compared to spatial transcriptomics, it provides comprehensive spatial information with single-cell resolution. By studying the spatial distribution of cells, we can clearly obtain the spatial context within tissues at multiple scales. Spatial context includes the spatial composition of cell types, the distribution of functional structures, and the spatial communication between functional regions, all of which are crucial for the patterns of cellular distribution. Here, we constructed a comprehensive spatial proteomics functional annotation knowledgebase, scProAtlas (https://relab.xidian.edu.cn/scProAtlas/#/), …

Aspdb: An Integrative Knowledgebase Of Human Protein Isoforms From Experimental And Ai-Predicted Structures, Yuntao Yang, Himansu Kumar, Yuhan Xie, Zhao Li, Rongbin Li, Wenbo Chen, Chiamaka S Diala, Meer A Ali, Yi Xu, Albon Wu, Sayed-Rzgar Hosseini, Erfei Bi, Hongyu Zhao, Pora Kim, W Jim Zheng

Faculty, Staff and Student Publications

Alternative splicing is a crucial cellular process in eukaryotes, enabling the generation of multiple protein isoforms with diverse functions from a single gene. To better understand the impact of alternative splicing on protein structures, protein-protein interaction and human diseases, we developed ASpdb (https://biodataai.uth.edu/ASpdb/), a comprehensive database integrating experimentally determined structures and AlphaFold 2-predicted models for human protein isoforms. ASpdb includes over 3400 canonical isoforms, each represented by both experimentally resolved and predicted structures, and >7200 alternative isoforms with AlphaFold 2 predictions. In addition to detailed splicing events, 3D structures, sequence variations and functional annotations, ASpdb uniquely offers comparative analyses and …

Metsdb: A Knowledgebase Of Cancer Metastasis At Bulk, Single-Cell And Spatial Levels, Sijia Wu, Jiajin Zhang, Yanfei Wang, Xinyu Qin, Zhaocan Zhang, Zhennan Lu, Pora Kim, Xiaobo Zhou, Liyu Huang

Faculty, Staff and Student Publications

Cancer metastasis, the process by which tumour cells migrate and colonize distant organs from a primary site, is responsible for the majority of cancer-related deaths. Understanding the cellular and molecular mechanisms underlying this complex process is essential for developing effective metastasis prevention and therapy strategies. To this end, we systematically analysed 1786 bulk tissue samples from 13 cancer types, 988 463 single cells from 17 cancer types, and 40 252 spots from 45 spatial slides across 10 cancer types. The results of these analyses are compiled in the metsDB database, accessible at https://relab.xidian.edu.cn/metsDB/. This database provides insights into alterations in …

Crisprofft: Comprehensive Database Of Crispr/Cas Off-Targets, Grant Wang, Xiaona Liu, Aoqi Wang, Jianguo Wen, Pora Kim, Qianqian Song, Xiaona Liu, Xiaobo Zhou

Faculty, Staff and Student Publications

The CRISPR (clustered regularly interspaced short palindromic repeats)/Cas (CRISPR-associated protein) programmable nuclease system continues to evolve, with in vivo therapeutic gene editing increasingly applied in clinical settings. However, off-target effects remain a significant challenge, hindering its broader clinical application. To enhance the development of gene-editing therapies and the accuracy of prediction algorithms, we developed CRISPRoffT (https://ccsm.uth.edu/CRISPRoffT/). Users can access a comprehensive repository of off-target regions predicted and validated by a diverse range of technologies across various cell lines, Cas enzyme variants, engineered sgRNAs (single guide RNAs) and CRISPR editing systems. CRISPRoffT integrates results of off-target analysis from 74 studies, encompassing …

The Manipulation Of Odor Availability Of Training Aids Used In Detection Canine Training, Katylynn B. Sloan, Michele N. Maughan, Caitlin E. Sharpes, Robin R. Greubel, Shawna F. Gallegos, Aleksandr E. Miklos, Lindsay D. Waldrop

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

Detection canines can identify numerous substances for which they have been trained. Historically, and a point of ongoing contention, detection canine threshold (i.e., sensitivity or limit of detection) training has primarily focused on changing the weight of the training aid substance used. There has been minimal focus on other principles, such as surface area, confinement, and temperature, which can be manipulated to affect odor availability. That said, trainers have been manipulating odor availability for years without necessarily understanding the governing scientific principles. The aim of this review is to highlight the principles that control odor availability of a substance and …

Myo5b And The Polygenic Landscape Of Very Early-Onset Inflammatory Bowel Disease In An Ethnically Diverse Population, Ashleigh Watson, R Alan Harris, Amy C Engevik, Numan Oezguen, Maribeth R Nicholson, Sarah Dooley, Rachel Stubler, Lisa Forbes Satter, Lina B Karam, Richard Kellermayer

Faculty, Staff and Students Publications

Background: Genetic discovery in very early-onset inflammatory bowel disease (VEO-IBD) can elucidate not only the origins of VEO-IBD, but also later-onset inflammatory bowel disease. We aimed to investigate the polygenic origins of VEO-IBD in a cohort with a high proportion of Hispanic patients.

Methods: Patients with VEO-IBD who underwent whole exome sequencing at our center were included. Genes were categorized as genes of interest (GOIs) (129 genes previously described to be associated with VEO-IBD) or non-GOIs. VEO-IBD "susceptibility" single nucleotide variants (SNVs) were identified through enrichment compared with gnomAD (Genome Aggregation Database) and ALFA (Allele Frequency Aggregator) and were scored …

Selectivity Of Invasive Species Suppression Efforts Influences Control Efficacy, Rae Fadlovich, Kevin Landom, Timothy E. Walsworth

Watershed Sciences Student Research

1. Highly fecund invaders and size-selective suppression efforts often limit the effectiveness of invasive species control programs, as compensatory processes can allow suppressed populations to recover. While population models have long explored how demographic characteristics impact management feasibility, there is a growing need to evaluate how the selectivity of suppression efforts might impact the long-term feasibility of control.
2. We use a simulation framework that integrates age-based selectivity to evaluate the effect of increasing the range of ages selected for during harvest-based invasive species control. We applied this approach to common carp in Utah Lake, the location of one of the world's …

Humans Are Not Normal: How Did This Happen?, Hermann Strasser

Sociology Between the Gaps: Forgotten and Neglected Topics

No abstract provided.

Gendered Sexual Behaviors: Unintended Pregnancies, And Sexually-Transmitted Infections, Deirdre Ferguson

All ETDs from UAB

Education is the most effective way to address unintended pregnancies and sexually-transmitted infections (STIs). Education through preventative counseling has been negatively correlated with unintended pregnancies. Although research has shed light on the risks posing challenges to the prevention of unintended pregnancies, the consequential costs of these pregnancies continue to mount, both individually and societally. Birth control counseling corresponds with reducing the behavior of nonuse of contraceptives significantly. Education is thus associated with combatting inaccurate information passed along via primary social groups. To gain insight into the prevention of unintended pregnancies and STIs, data was gathered using a mixed-method approach incorporating …