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The Effects Of Irrelevant Parameters In Language Acquisition, Yukun Zhang

Dissertations, Theses, and Capstone Projects

This paper investigates the effects of sententially irrelevant syntactic information on language acquisition models and introduces a new variant of the variational learner (VL) called the early decision variational learner (EDVL). EDVL accelerates convergence by locking in parameter values once they reach a threshold, in contrast to VL’s continued adjustments until all parameter values reach threshold. Both learners are grounded in the generative approach to language acquisition. We examine both learners' responses when they only update their parameter values when the input contain the relevant information to determin the parameter value such as prepositions, wh-words, and auxiliary verbs. Chapter 1 …

The Psychophysiology Of Primary And Secondary Variants Of Psychopathic Traits In Youth, Ines Guariguata

Dissertations, Theses, and Capstone Projects

Psychopathy is a cluster of personality traits marked by a pervasive callousness, lack of shame or remorse, deceitfulness, a persona of confidence and charm, shallow emotional connection, general lack of insight into their actions, and an absence of anxiety (Glenn & Raine, 2014; Hare, 2003). Research suggests that there are distinct etiological pathways to the development of psychopathic traits and that their responses to treatment are different (Craig et al., 2021; Yildrim & Derksen, 2015; Fleming et al., 2023). Primary variants show a low-fear, low-anxiety profile during stress, and have a genetic basis (Craig et al., 2021; Yildrim & Derksen, …

Tracing The Sources Of Nitrogen In Submarine Groundwater Discharge And Primary Producers In The Great South Bay Estuary, Nia H. Rene

Dissertations, Theses, and Capstone Projects

The primary aim of this research was to elucidate the impact of submarine groundwater discharge (SGD) and septic effluent on coastal primary producers in the Great South Bay (GSB). The study focused on three main objectives: assessing the impact of precipitation patterns on SGD, tracing nitrogen sources into the GSB, and determining the impact of these nitrogen sources on coastal primary producers. The research revealed that current precipitation patterns significantly influence SGD across different seasons, highlighting the seasonal variability in groundwater discharge and its implications for nutrient loading in coastal waters. A suite of tracers was employed to identify and …

Advancing Structural And Textual Guidance In Medical Image Segmentation: A Journey From Fully Supervised To Weakly Supervised Learning, Jiaqi Yang

Dissertations, Theses, and Capstone Projects

Accurate segmentation of medical images is essential for clinical diagnosis, enabling precise measurement, monitoring, and analysis of anatomical structures. While advanced models have achieved impressive per-pixel performance under fully supervised settings, ensuring fine-scale structural completeness remains a challenge, particularly for complex biomedical structures where coherence and integrity are critical. Fully supervised methods also face inherent limitations due to their reliance on extensive pixel-level annotations. These annotations are labor-intensive, costly, and often suffer from low inter-expert agreement, especially in cases like OCT images where small lesions and unclear boundaries make precise labeling difficult. This underscores the challenge of acquiring large, high-quality …

Does Treatment Setting In Ati Matter? An Examination Of Completion Rates And The Role Of Violent Charges Among Individuals With Co-Occurring Disorders, George J. Anderson

Dissertations, Theses, and Capstone Projects

Despite the proliferation of alternatives to incarceration (ATI) for individuals with co-occurring disorders in recent decades, little is known about comparative styles of treatment used in this context. The following study uses data from a case management service in a large urban city (n=273) where several types of treatment are utilized in the ATI landscape. Specifically, this study compares ATI completion rates and time to completion or failure for several styles of treatment: clinic-based outpatient, residential, assertive community treatment (ACT) and personalized recovery-oriented services (PROS) programs. Results of a logistic regression indicate that individuals initially referred to residential treatment had …

Taming Biological Complexity Through The Use Of Symmetries, Luis A. Álvarez-García

Dissertations, Theses, and Capstone Projects

The study of biological systems is, inherently, the study of very complex systems. This is essentially due to the fact that they are made up of numerous, often very complicated, interactions between an extensive number of components. Often necessitating an abundance of quantitative parameters and details for a precise description. The human brain for ex- ample, consisting of ∼ 80 billion neurons with ∼ 800 to 100 trillion connections between them, each of them depending on a large set of parameters. Even simpler examples such as bacterial organisms, such as E. coli and B. subtilis, which we focus on …

Solvation Thermodynamic Mapping Approaches For Computer-Aided Drug Discovery, Vjay Molino

Dissertations, Theses, and Capstone Projects

The drug discovery process is inherently long and costly, prompting the development and integration of computational tools to mitigate these challenges. One of area explored in computer-aided drug discovery is to understand the role of solvation in protein-drug binding and to develop computational tools and methods that can be integrated in the drug discovery process. Grid Inhomogeneous Solvation Theory (GIST) is a tool that provides a framework for mapping solvation thermodynamiproperties of water molecules on the protein surface.This thesis explores the use of GIST in generating pharmacophore models and elucidates the role of solvation in protein structural fluctuations.

One of …

Development Of Soil Survey Methods For Urban Areas, Kohinoor Begum

Dissertations, Theses, and Capstone Projects

Urban soils are the foundation of urban ecosystems and play a vital role in long-term urban sustainability and resiliency. Accurate soil surveys of urban areas should be done at higher resolution since extensive human activities often result in urban soil being highly disturbed and spatially variable. Besides heterogeneity, one of the unique and challenging aspects of urban soil is the nature and properties of its organic carbon with a significant percentage of black carbon (a particulate product of incomplete combustion), which is less biologically active. Thus, in order to determine the ability of a soil to support biological activity and …

Novel Alchemical Methodologies For Modeling Molecular Binding, Solmaz Azimi

Dissertations, Theses, and Capstone Projects

Molecular recognition is fundamental to all biological and biochemical processes. Understanding the interactions between molecules is the foundation for drug discovery and development, for understanding biological processes, and for the design of biosensors and nanomaterials. There is tremendous interest in the development of computer models to predict molecular association equilibria. In structure-based drug discovery enterprises, predicting the strength and selectivity of a small molecule to a biological target can advance target identification, aid ligand design, and accelerate high-throughput screening of drug compounds. This work focuses on free energy models, a class of computational methodologies grounded on the fundamental physical and …

Cueing Motions In A String Quartet, An Exploratory Study Of Motion Trajectories, Maren Rothfritz

Dissertations, Theses, and Capstone Projects

A string quartet performance involves an array of different body movements which serve many functions, including sound production, expression, and communication. This dissertation examines the ways string quartet players execute specific communicative body motions called cues, which are anticipatory gestures meant to communicate tempo and timing as well as the musical intentions such as dynamics, articulation, and character to the co-performers. Some scholarly research exists on cueing, but a formalized description of the cueing motions involved has not yet been developed. This dissertation serves as an exploratory study examining the motion trajectories of cueing motions employed by the Argus Quartet, …

Evidence For Interactive Effects Of Inhibitory And Prospective Intolerance Of Uncertainty And Stimulus-Level Uncertainty On Threat Safety Discrimination Learning, Kyoko Yazaki

Dissertations, Theses, and Capstone Projects

Fear is a fundamental component of human learning, critical for survival, and extensively studied through Pavlovian conditioning paradigms (LeDoux & Pine, 2016). This thesis examines the interplay between stimulus-level uncertainty and individual differences in intolerance of uncertainty (IU) on threat-safety discrimination learning. Using a within-subject design, participants were conditioned to certain (100% reinforcement), uncertain (50% reinforcement), and safety (0% reinforcement) cues through the pairing of colored visual stimuli with aversive electrical shocks. Discrimination learning was assessed using both implicit (SCR) and explicit (self-reported US expectancy estimates and unpleasantness ratings) measures.

The present study (n = 102) replicated previous findings showing …

Chatgpt Didn’T Write This: Evaluating The Impact Of Llms With A Case Study In Grading Cuny Language Immersion Program Student Essays, Benjamin Inbar

Dissertations, Theses, and Capstone Projects

This study evaluates the capabilities and limitations of large language models (LLMs), specifically OpenAI’s ChatGPT-4o, in grading essays from students in the City University of New York’s Language Immersion Program. The program serves English language learners with diverse linguistic and demographic backgrounds, offering intensive language instruction to prepare students for academic success in college. Using a dataset of 30 pre- and post-program essays scored by program instructors and ChatGPT-4o under three paradigms, this research explores the alignment between human and AI-generated scores across five rubric-based competency areas. Findings reveal that ChatGPT-4o aligns moderately with human grading, with the strongest agreement …

Beyond The Sum: A Network Analysis Of Adverse Childhood Experiences And Behavioral Outcomes In Justice-Involved Youth, Jennifer Yang

Dissertations, Theses, and Capstone Projects

This dissertation examines gender-specific patterns of adverse childhood experiences (ACEs) among justice-involved youth using network analysis. Despite experiencing higher rates of childhood adversity, female youth show lower recidivism rates than males, presenting an empirical paradox. Using a sample of 19,454 justice-involved youth (75% male), this study applies novel network methods to understand how ACEs and behavioral outcomes are organized across gender. Findings reveal distinct network architectures: female youth maintain more integrated but vulnerable networks, while males show more compartmentalized but stable structures. Female recidivists demonstrate systematic network destabilization when compared to non-recidivists, characterized by a 39% reduction in network density, …

Characterizing Malaria Infections In Caribbean Lizards: Parasite Niche Expansion & Host Response, Sarah J. Pangburn

Dissertations, Theses, and Capstone Projects

Malaria is historically one of the most severe parasitic human diseases and is still responsible for over half a million deaths annually. Plasmodium species, the causative agents of malaria, are often characterized by two hallmark features of their asexual stages: the invasion of vertebrate red blood cells and the presence of hemozoin pigment as a byproduct of host hemoglobin digestion. Despite their evolutionary relatedness to mammalian Plasmodium, wildlife malaria parasites are understudied, leaving their vast genetic diversity to be explored. Lizard-infective malaria parasites, for example, include over 100 species of Plasmodium and present a diverse array of phenotypes, some …

Freedom Pedagogy: Black Educators In The Urban North During The Nineteenth And Early Twentieth Centuries, Milagros Seraus-Roache

Dissertations, Theses, and Capstone Projects

Black educational history has been told through a predominantly Southern lens. This dissertation highlights the experiences of Black educators in the urban North during the nineteenth and early twentieth centuries. Northern Black educators confronted the challenges of freedom—including the constant need to protect it—using a set of approaches influenced by the various intersecting social movements and intellectual currents of their day. While these educators represented a small minority of African Americans, their contributions were profound, leaving legacies that provide a lens for understanding and improving issues facing urban Black youth and their communities today.

In the absence of a comprehensive …

Mad At The System: The Mental Health Act Uk: Power And Control Of Racialized Women, Maithreyi Rajeshkumar

Dissertations, Theses, and Capstone Projects

Whilst experiences of madness are multiple, fluid and multi-dimensional across spiritual and collective dimensions globally, the categorization and regulation of ‘madness’ have direct foundations in European colonial-capitalist-patriarchal frameworks, policies and systems. This work focuses on the institutions and structures of power, turning UK legislation and those who are trying to reform or change it, into objects of study. A particular piece of United Kingdom legislation is the primary case study for this work – the Mental Health Act 1983 which covers the rights, assessment and treatment of people diagnosed with a ‘mental disorder’. Women, who are detained under this Act …

Sex-Specific And Regional Analysis Of Heart Disease Prediction Using Machine Learning Algorithms: Insights From The Uc Irvine Public Heart Disease Datasets (Cleveland And Long Beach), Jonathan Asanjarani

Dissertations, Theses, and Capstone Projects

For this capstone project, I investigated how well machine learning models can predict heart disease, while also studying how the patient’s gender affects these predictions, as well as determining how well the same model performs across different regions. This project utilizes two clinical datasets from the publicly accessible UCI Machine Learning Repository under the collection "Heart Disease." This repository is composed of data from patients across four distinct locations, capturing varying levels of heart disease severity. These datasets are part of a collection of databases, open to the public, and can be used by anyone looking to conduct empirical analysis. …

Notch3 Deletion Regulates Hiv-1 Gene Expression And Systemic Inflammation To Ameliorate Chronic Kidney Disease, Mackenzie Thornton, Nicole Sommer, Mercedes Mcgonigle, Anil Kumar Ram, Sireesha Yerrathota, Henrietta Ehirim, Aakriti Chaturvedi, Johnny Dinh Phan, Anubhav Chakraborty, V. Praveen Chakravarthi, Sumedha Gunewardena, Mudit Tyagi, Jaya Talreja, Tao Wang, Pravin Singhal, Pamela V. Tran, Timothy A. Fields, Patricio E. Ray, Navneet K. Dhillon, Madhulika Sharma

Center for Translational Medicine Faculty Papers

Anti-retroviral therapy (ART) has decreased human immunodeficiency virus (HIV)-1-associated morbidity. However, despite ART, immune cells remain latently infected, leading to chronic inflammation and HIV-1-associated comorbidities. New strategies are needed to target viral proteins and inflammation. We found activation of Notch3 in renal cells of the HIV-1 transgenic mouse model (HIV-Tg26) and in patients with HIV-associated nephropathy. We hypothesized that targeting NOTCH3 activation constitutes an effective therapy for HIV-related chronic kidney disease. We generated HIV-Tg26 mice with Notch3 knocked out (Tg-N3KO). Compared to HIV-Tg26 mice at 3 months, Tg-N3KO mice showed a marked reduction in renal injury, skin lesions and mortality …

Investigating The Risk And Protective Factors Of Internet Addiction Among Adolescents Through The Lens Of Cognitive Behavioral Theory: A Cross-Sectional Study, Noura Shaltout

Theses and Dissertations

—Introduction: The Internet has become a central part of modern life, enhancing education, providing means of global communication, and facilitating access to information and entertainment. However, an attendant risk of excessive Internet use is becoming unconsciously addicted to virtual online activities, especially when large tech companies design their products in a way that makes them addictive to users. These companies have the tools and knowledge that allow them to manipulate and transform the behavior of their target audience. Thus, this study aimed to investigate the potential risk and protective factors for Internet addiction among adolescents. Methodology: This cross-sectional study employed …

Test Of Strategies For Production And Harvest Of Edible Roots From Hydroponic Plants, Mariam Yaslem Albreiki

Theses

Hydroponic plant cultivation is becoming increasingly popular in the UAE, especially for leafy greens and fruit vegetables. By the end of the growing cycle, the roots of hydroponic plants are usually treated as crop residues, even though roots of several species are potentially edible and could be processed into food or nutraceuticals. Root crops like sweet potato or carrot might even be grown in hydroponic systems for the primary purpose of producing edible fibrous or tuberous roots. However, the use of hydroponic systems for the production of root biomass is not yet common, and most farmers strive to produce plants …

Gdp-Mannose 4,6-Dehydratase Is A Key Driver Of Mycn-Amplified Neuroblastoma Core Fucosylation And Tumorigenesis, Beibei Zhu, Michelle G. Pitts, Michael D. Buoncristiani, Lindsay T. Bryant, Oscar Lopez-Nunez, Juan P. Gurria, Cameron Shedlock, Roberto Ribas, Shannon Keohane, Jinpeng Liu, Chi Wang, Matthew S. Gentry, Nathan R. Shelman, Derek B. Allison, B. Mark Evers, Ramon C. Sun, Eric J. Rellinger

Markey Cancer Center Faculty Publications

MYCN-amplification is a genetic hallmark of ~40% of high-risk neuroblastomas (NBs). Altered glycosylation is a common feature of adult cancer progression, but little is known about how genetic signatures such as MYCN-amplification alter glycosylation profiles. Herein, matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI) revealed increased core fucosylated glycan abundance within neuroblast-rich regions of human MYCN-amplified NB tumors. GDP-mannose 4,6-dehydratase (GMDS) is responsible for the first-committed and rate-limiting step of de novo GDP-fucose synthesis. High GMDS expression was found to be associated with poor patient survival, advanced stage disease, and MYCN-amplification in human NB tumors. Chromatin immunoprecipitation and promoter reporter assays …

A Microrna-Regulated Transcriptional State Defines Intratumoral Cd8+ T Cells That Respond To Immunotherapy, William W. Tang, Ben Battistone, Kaylyn M. Bauer, Allison M. Weis, Cindy Barba, Muhammad Zaki Hidayatullah Fadlullah, Arevik Ghazaryan, Van B. Tran, Soh-Hyun Lee, Z. Busra Agir, Morgan C. Nelson, Emmanuel Stephen Victor, Amber Thibeaux, Colton Hernandez, Jacob Tantalla, Aik C. Tan, Dinesh Rao, Matthew Williams, Micah J. Drummond, Ellen J. Beswick, June L. Round, H. Atakan Ekiz, Warren P/ Voth, Ryan M. O’Connell

Markey Cancer Center Faculty Publications

The rising incidence of advanced-stage colorectal cancer (CRC) and poor survival outcomes necessitate new and effective therapies. Immune checkpoint inhibitors (ICIs), specifically anti-PD-1 therapy, show promise, yet clinical determinants of a positive response are suboptimal. Here, we identify microRNA-155 (miR-155) as necessary for CD8 + T cell-infiltrated tumors through an unbiased in vivo CRISPR-Cas9 screen identifying functional tumor antigen-specific CD8+ T cell-expressed microRNAs. T cell miR-155 is required for anti-PD-1 responses and for a vital intratumor CD8 + T cell differentiation cascade by repressing Ship-1, inhibiting Tcf-1 and stemness, and subsequently enhancing Cxcr6 expression, anti-tumor immunity, and effector functions. Based …

Staying Sane In The Membrane: Neutral Sphingomyelinase 2 As A Master Regulator Of Plasma Membrane Ceramide, Zainuddin Quadri, Erhard Bieberich

Markey Cancer Center Faculty Publications

Ceramide, a key signaling sphingolipid in the plasma membrane, plays a pivotal role in fundamental cellular processes such as adhesion, polarity, and programmed cell death. The generation of plasma membrane ceramide is largely attributed to the activity of two types of sphingomyelinases: neutral sphingomyelinase 2 (nSMase2, Smpd3) and acid sphingomyelinase (aSMase, Smpd1). While many studies have explored ceramide generation following experimental activation of these enzymes, the mechanisms governing basal or steady- state ceramide levels have remained poorly understood. Using an innovative mass spectrometry approach developed in the Canals’ lab, the team has quantified the distinct contributions of nSMase2 and aSMase …

The Mitochondria As An Emerging Target Of Self- Renewal In T-Cell Acute Lymphoblastic Leukemia, Majd Al-Hamaly, Evelyn Winter, Jessica S. Blackburn

Markey Cancer Center Faculty Publications

Acute lymphocytic leukemia (ALL) is the most common leukemia in children, with the T-cell subtype (T- ALL) accounting for 15% of those cases. Despite advancements in the treatment of T-ALL, patients still face a dismal prognosis following their first relapse. Relapse can be attributed to the inability of chemotherapy agents to eradicate leukemia stem cells (LSC), which possess self-renewal capabilities and are responsible for the long-term maintenance of the disease. Mitochondria have been recognized as a therapeutic vulnerability for cancer stem cells, including LSCs. Mitocans have shown promise in T-ALL both in vitro and in vivo, with some currently in …

Gdp-Mannose 4,6-Dehydratase Is A Key Driver Of Mycn- Amplified Neuroblastoma Core Fucosylation And Tumorigenesis, Beibei Zhu, Michelle G. Pitts, Michael D. Buoncristiani, Lindsay T. Bryant, Oscar Lopez-Nunez, Juan P. Gurria, Cameron Shedlock, Roberto Ribas, Shannon Keohane, Jinpeng Liu, Chi Wang, Matthew S. Gentry, Nathan R. Shelman, Derek B. Allison, B. Mark Evers, Ramon C. Sun, Eric J. Rellinger

Markey Cancer Center Faculty Publications

MYCN-amplification is a genetic hallmark of ~40% of high-risk neuroblastomas (NBs). Altered glycosylation is a common feature of adult cancer progression, but little is known about how genetic signatures such as MYCN-amplification alter glycosylation profiles. Herein, matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI) revealed increased core fucosylated glycan abundance within neuroblast-rich regions of human MYCN-amplified NB tumors. GDP-mannose 4,6-dehydratase (GMDS) is responsible for the first-committed and rate-limiting step of de novo GDP-fucose synthesis. High GMDS expression was found to be associated with poor patient survival, advanced stage disease, and MYCN-amplification in human NB tumors. Chromatin immunoprecipitation and promoter reporter assays …

Tracking Community Outreach And Engagement Activities Among National Cancer Institute-Designated Cancer Centers, Todd Burus, Caree Mcafee, Pamela Hull, Amy Leader, Christopher Mcnair

Kimmel Cancer Center Faculty Papers

The National Cancer Institute's (NCI) Cancer Center Support Grant mandates that NCI-designated cancer centers establish a Community Outreach and Engagement (COE) component to help direct efforts at reducing cancer burden within their catchment areas. Despite the critical role of COE offices, little is known about how they track and evaluate outreach activities and outcomes. We gathered information on current practices from representatives of 40 out of 65 COE offices using an online survey. Although nearly all responding centers (97.5%) tracked COE activities, no consensus existed on resources used, and satisfaction with current solutions was mixed (51.0% not satisfied). Respondents expressed …

Association Between Factor I Fibrinogen (Rs6050) And Factor Xi Plasma Thromboplastin (Rs4253417) Genetic Polymorphisms And Recurrent Spontaneous Miscarriage In Saudi Women, Aaishah M. Kaabi, Afrah F. Alkhuriji, Zeneb A. Babay, Ibrahim A. Barakat, Abdullah M. Kaabi, Reem M. Kaabi

Saudi Medical Journal

Objectives: To identify genetic polymorphisms in factor I fibrinogen (rs6050) and factor XI plasma thromboplastin (rs4253417) in Saudi women with recurrent spontaneous miscarriage (RSM). Furthermore, to compare the levels of clotting factors in the blood of patients and healthy controls. Methods: The current study was conducted at the King Khalid University Hospital in Riyadh, Saudi Arabia, from September 2022 to June 2023. The study involved 100 Saudi women, 50 pregnant and 50 non-pregnant individuals, who experienced RSM. Furthermore, 100 healthy Saudi women, including 50 pregnant and 50 non-pregnant individuals, were also included as controls. TaqMan genotyping assays were used to …

Risk Factors For Depression Symptoms In Adolescents: A Population-Based Study, Dewinda Candrarukmi, Fitri Hartanto, Tunjung Wibowo, Hari W. Nugroho, Moh S. Anam, Braghmandita W. Indraswari, Qodri Santosa, Nazliah Hanum

Saudi Medical Journal

Objectives: To ascertain the prevalence of depressive symptoms and identify related risk factors among adolescents. Methods: A cross-sectional survey was carried out using an online questionnaire completed by 1,413 adolescents from Central Java and Yogyakarta Provinces، Indonesia. The validated Indonesian version of the Children’s Depression Inventory (CDI) was used to evaluate depressive symptoms. Results: Symptoms of depression were identified in 28.5% of participants. Multivariate analysis revealed important risk factors, including female gender (OR 3.962, 95% CI 2.684–5.849), having mother who is a housewife (OR 4.155, 95% CI 1.424–12.126) or works in labor/farming/self-employment (OR 3.665, 95% CI 1.216–11.051), residing with a …

Effective Business Promotion Strategies Small Business Owners Use To Improve Revenue And Increase Business Viability, Shirley Owusu-Ankomah

Walden Dissertations and Doctoral Studies

Small businesses are vital to national and local economies, yet many struggle to sustain operations in the long term. A significant concern for small business owners is the lack of effective promotion strategies, a key factor in business failure. Grounded in open system theory, the purpose of this multiple case study was to investigate the promotion strategies employed by small business owners to improve revenue and increase business viability. The participants were six small business owners from Sekondi-Takoradi in Ghana’s Western Region, who successfully utilized strategies to improve revenue and maintain their businesses. Data sources included semistructured interview data and …

A Qualitative Analysis Of Awareness And Perceptions Of African Immigrant Men Regarding Hpv Vaccine Uptake In Children To Prevent Cervical Cancer, Netsai Nancy Mariga Andere

Walden Dissertations and Doctoral Studies

Low Human Papillomavirus (HPV) vaccine acceptance remains one of the most crucial disparities in the US by country of origin among children. The study aims to qualitatively explore the HPV and HPV vaccine awareness and perceptions among African immigrant men to help reduce the HPV-related cervical cancer burden among African immigrants living in the US. The health belief model (HBM) was used for this basic qualitative study of self-reported awareness and perception among African immigrant men in the US with responses from 11 individual interviews. Thematic analysis was utilized to analyze the data collected from the interview responses. Six themes …