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An Integrated Global-To-Regional Scale Workflow For Simulating Climate Change Impacts On Marine Ecosystems, Kelly Ortega-Cisneros, Denisse Fierros-Arcos, Max Lindmark, Camilla Novaglio, Phoebe Woodworth-Jefcoats, Tyler D. Eddy, Marta Coll, Elizabeth Fulton, Ricardo Oliveros-Ramos, Jonathan Reum, Yunne Jai Shin, Cathy Bulman, Leonardo Capitani, Samik Datta, Kieran Murphy, Alice Rogers, Lynne Shannon, George A. Whitehouse, Ezekiel Adekoya, Beatriz S. Dias, Alba Fuster-Alonso, Cecilie Hansen, Bérengère Husson, Vidette Mcgregor, Alaia Morell, Hem Nalini Morzaria Luna, Jazel Ouled-Cheikh, James Ruzicka, Jeroen Steenbeek, Ilaria Stollberg, Roshni C. Subramaniam, Vivitskaia Tulloch, Andrea Bryndum-Buchholz Feb 2025

An Integrated Global-To-Regional Scale Workflow For Simulating Climate Change Impacts On Marine Ecosystems, Kelly Ortega-Cisneros, Denisse Fierros-Arcos, Max Lindmark, Camilla Novaglio, Phoebe Woodworth-Jefcoats, Tyler D. Eddy, Marta Coll, Elizabeth Fulton, Ricardo Oliveros-Ramos, Jonathan Reum, Yunne Jai Shin, Cathy Bulman, Leonardo Capitani, Samik Datta, Kieran Murphy, Alice Rogers, Lynne Shannon, George A. Whitehouse, Ezekiel Adekoya, Beatriz S. Dias, Alba Fuster-Alonso, Cecilie Hansen, Bérengère Husson, Vidette Mcgregor, Alaia Morell, Hem Nalini Morzaria Luna, Jazel Ouled-Cheikh, James Ruzicka, Jeroen Steenbeek, Ilaria Stollberg, Roshni C. Subramaniam, Vivitskaia Tulloch, Andrea Bryndum-Buchholz

Faculty Publications

As the urgency to evaluate the impacts of climate change on marine ecosystems increases, there is a need to develop robust projections and improve the uptake of ecosystem model outputs in policy and planning. Standardizing input and output data is a crucial step in evaluating and communicating results, but can be challenging when using models with diverse structures, assumptions, and outputs that address region-specific issues. We developed an implementation framework and workflow to standardize the climate and fishing forcings used by regional models contributing to the Fisheries and Marine Ecosystem Model Intercomparison Project (FishMIP) and to facilitate comparative analyses across …


Family Structure And Parents’ Perceptions Of The Importance Of Youth Developmental Assets: Challenging The Deficit Orientation Of Structurally Diverse Families, Jonathon J. Beckmeyer, Luke T. Russell, Gabrielle C. Kline Feb 2025

Family Structure And Parents’ Perceptions Of The Importance Of Youth Developmental Assets: Challenging The Deficit Orientation Of Structurally Diverse Families, Jonathon J. Beckmeyer, Luke T. Russell, Gabrielle C. Kline

Faculty Publications - Family and Consumer Sciences

Critical family scholars have highlighted that structurally diverse families (e.g. stepfamilies, single-parent families) are often unfairly viewed through a deficit-comparison lens. This includes assumptions that these families are less optimal contexts for raising children than married different-sex nuclear families or hold different parenting and family values. In the present study, we sought to challenge that assumption by having parents rate the importance of developmental assets for their adolescent children and then comparing perceived importance across family structures. To do so we used data from 354 parents (24.6% single-parent families, 16.7% stepfamilies, 58.8% two-biological/adoptive parent families). We found that the overwhelming …


Blast Tube Design: How Shape And Size Influence The Resultant Shock Wave, R. L. Bauer, C. E. Johnson Feb 2025

Blast Tube Design: How Shape And Size Influence The Resultant Shock Wave, R. L. Bauer, C. E. Johnson

Mining Engineering Faculty Research & Creative Works

Shock tubes and tunnels are often used in research settings as a way of producing high pressure shock waves in a smaller footprint or without the use of explosives. However, there is no standard geometric design across laboratories. Peak pressure is a significant parameter for characterizing a shock wave. However, different tube configurations could also affect parameters such as impulse and duration, yet no research has investigated how the scale of the tube affects the overall waveform shape. To understand the implications of shock tube design, tubes with a constant length to diameter ratio were evaluated to determine how tube …


Tremblings, February 2025, Western Aspen Alliance Feb 2025

Tremblings, February 2025, Western Aspen Alliance

Tremblings

Bridging Conservation Science With Native Meaning

James Calabaza, Indigenous Lands Director; Trees, Water & People

Last fall, I had the privilege of collaborating with the Western Aspen Alliance and other partners to carry out a 3-day workshop focused on quaking aspen genetics, fire ecology, and co-stewardship. Held at Rocky Mountain Biological Laboratory (Gothic, Colorado), the workshop brought together academics, NGOs, federal agencies, and Tribal members to share diverse perspectives on aspen's significance and management futures.


February 2025 Cafe Newsletter, Center For Advancing Faculty Excellence Feb 2025

February 2025 Cafe Newsletter, Center For Advancing Faculty Excellence

CAFE Faculty Newsletters

No abstract provided.


What We Mean When We Say Semantic: Toward A Multidisciplinary Semantic Glossary, Jamie Reilly, Cory Shain, Valentina Borghesani, Philipp Kuhnke, Gabriella Vigliocco, Jonathan E. Peelle, Bradford Z. Mahon, Laurel J. Buxbaum, Asifa Majid, Marc Brysbaert, Anna M. Borghi, Simon De Deyne, Guy Dove, Liuba Papeo, Penny M. Pexman, David Poeppel, Gary Lupyan, Paulo Boggio, Gregory Hickok, Laura Gwilliams, Leonardo Fernandino, Daniel Mirman, Evangelia G. Chrysikou, Chaleece W. Sandberg, Sebastian J. Crutch, Liina Pylkkänen, Eiling Yee, Rebecca L. Jackson, Jennifer M. Rodd, Marina Bedny, Louise Connell, Markus Kiefer, David Kemmerer, Greig De Zubicaray, Elizabeth Jefferies, Dermot Lynott, Cynthia S. Q. Siew, Rutvik H. Desai, Ken Mcrae, Michele T. Diaz, Marianna Bolognesi, Evelina Fedorenko, Swathi Kiran, Maria Montefinese, Jeffrey R. Binder, Melvin J. Yap, Gesa Hartwigsen, Jessica Cantlon, Yanchao Bi, Paul Hoffman, Frank E. Garcea, David Vinson Feb 2025

What We Mean When We Say Semantic: Toward A Multidisciplinary Semantic Glossary, Jamie Reilly, Cory Shain, Valentina Borghesani, Philipp Kuhnke, Gabriella Vigliocco, Jonathan E. Peelle, Bradford Z. Mahon, Laurel J. Buxbaum, Asifa Majid, Marc Brysbaert, Anna M. Borghi, Simon De Deyne, Guy Dove, Liuba Papeo, Penny M. Pexman, David Poeppel, Gary Lupyan, Paulo Boggio, Gregory Hickok, Laura Gwilliams, Leonardo Fernandino, Daniel Mirman, Evangelia G. Chrysikou, Chaleece W. Sandberg, Sebastian J. Crutch, Liina Pylkkänen, Eiling Yee, Rebecca L. Jackson, Jennifer M. Rodd, Marina Bedny, Louise Connell, Markus Kiefer, David Kemmerer, Greig De Zubicaray, Elizabeth Jefferies, Dermot Lynott, Cynthia S. Q. Siew, Rutvik H. Desai, Ken Mcrae, Michele T. Diaz, Marianna Bolognesi, Evelina Fedorenko, Swathi Kiran, Maria Montefinese, Jeffrey R. Binder, Melvin J. Yap, Gesa Hartwigsen, Jessica Cantlon, Yanchao Bi, Paul Hoffman, Frank E. Garcea, David Vinson

Moss-Magee Rehabilitation Papers

Tulving characterized semantic memory as a vast repository of meaning that underlies language and many other cognitive processes. This perspective on lexical and conceptual knowledge galvanized a new era of research undertaken by numerous fields, each with their own idiosyncratic methods and terminology. For example, "concept" has different meanings in philosophy, linguistics, and psychology. As such, many fundamental constructs used to delineate semantic theories remain underspecified and/or opaque. Weak construct specificity is among the leading causes of the replication crisis now facing psychology and related fields. Term ambiguity hinders cross-disciplinary communication, falsifiability, and incremental theory-building. Numerous cognitive subdisciplines (e.g., vision, …


Amyloid-Β Predominant Alzheimer’S Disease Neuropathologic Change, Gabor G. Kovacs, Yuriko Katsumata, Xian Wu, Khine Zin Aung, David Fardo, Shelley L. Forrest, Peter T. Nelson Feb 2025

Amyloid-Β Predominant Alzheimer’S Disease Neuropathologic Change, Gabor G. Kovacs, Yuriko Katsumata, Xian Wu, Khine Zin Aung, David Fardo, Shelley L. Forrest, Peter T. Nelson

Neurology Faculty Publications

Different subsets of Alzheimer’s disease neuropathologic change (ADNC), including the intriguing set of individuals with severe/widespread amyloid-β (Aβ) plaques but no/mild tau tangles [Aβ-predominant (AP)-ADNC], may have distinct genetic and clinical features. Analysing National Alzheimer’s Coordinating Center data, we stratified 1187 participants into AP-ADNC (n = 95), low Braak primary age-related tauopathy (PART; n = 185), typical-ADNC (n = 832) and high-Braak PART (n = 75). AP-ADNC differed in some clinical features and genetic polymorphisms in the APOE, SNX1, WNT3/MAPT and IGH genes. We conclude that AP-ADNC differs from classical ADNC with implications for in vivo studies.


Forgotten Victims: Exploring The Right To Family Integrity As A Form Of Redress For Children Of Wrongfully Convicted Parents, Emily Byers Olson Feb 2025

Forgotten Victims: Exploring The Right To Family Integrity As A Form Of Redress For Children Of Wrongfully Convicted Parents, Emily Byers Olson

Minnesota Law Review Vols. 106:2 onward (2021-present)

Almost five million children in the United States have had a parent incarcerated at some point in their lives. Children who grow up with an incarcerated parent face immense challenges, including mental health issues, problems at school, economic hardship, and the propensity to participate in criminal activity themselves. When it turns out that the child’s parent was wrongfully convicted and incarcerated for a crime they did not commit, the challenges faced by the child are even more devastating. One way that a child may be able to obtain a remedy in these instances is through their due process right to …


Understanding Women Leaders’ Perceptions Of Compassion In Higher Education, Elle (Kelleen H.) Griffin Feb 2025

Understanding Women Leaders’ Perceptions Of Compassion In Higher Education, Elle (Kelleen H.) Griffin

Doctor of Education (EdD)

This qualitative research study was conducted to better understand women leaders’ perceptions of compassion in higher education. Specifically, what are the types of distressing events and the settings wherein a compassionate response was offered; what are the compassionate actions experienced or offered, and what might enhance or inhibit the process of compassion. The study was also conducted to examine if and how compassion enhances or influences learning (Knowles, 2011), growing and healing (Rogers, 1967), and thriving at work (McGregor, 1960). Kanov et al.’s (2017) process theory of compassion was used as the theoretical framework to gain insight into compassion in …


Enhancing Elementary Students Conceptual Understandings Of Scientific Phenomena: The Impact Of Steam-First And Stem-First Approaches, Michael W. Corrigan, Joseph T. Wong, Doug Grove, Sage Anderson, Bradley S. Hughes Feb 2025

Enhancing Elementary Students Conceptual Understandings Of Scientific Phenomena: The Impact Of Steam-First And Stem-First Approaches, Michael W. Corrigan, Joseph T. Wong, Doug Grove, Sage Anderson, Bradley S. Hughes

Elementary & Secondary Education Faculty Research

This study delves into the realm of student conceptual change, examining shifting understandings as important steppingstones on the path to sensemaking and canonical understanding in science education. It explores the potential of a STEAM (Science, Technology, Engineering, Arts, and Math) curriculum, aiming to provide equitable learning opportunities, especially for emerging bilingual (EB) student populations. To achieve this, elementary school educators from randomly assigned schools received professional development training to implement a novel curriculum encompassing both STEM and STEAM (STEM + Arts) approaches to life science instruction. These approaches comprised: (1) an NGSS-aligned STEM unit employing inquiry-based science instruction; (2) an …


Climate Change And Sexual And Reproductive Health, Population Council Feb 2025

Climate Change And Sexual And Reproductive Health, Population Council

Climate and Environmental Changes

The Council's Population, Environmental Risks, and the Climate Crisis (PERCC) Initiative tracks direct and indirect links between climate hazards to sexual and reproductive health outcomes, with a focus on extreme heat and salinity. In this brief, we highlight evidence and solutions on sexual and reproductive health and rights (SRHR) in disaster settings; SRHR linkages with arsenic and highly saline drinking water, fertility and drought; and demographic shifts following disasters.


“We Don’T Have To Take Things So Seriously”: Humor, Queer Livability, And Homonormativity For A Rural English Language Arts Teacher, Brandon Haskey-Valerius, Ryan Schey Feb 2025

“We Don’T Have To Take Things So Seriously”: Humor, Queer Livability, And Homonormativity For A Rural English Language Arts Teacher, Brandon Haskey-Valerius, Ryan Schey

The Rural Educator

Extending and challenging existing research about LGBTQIA+ life in rural educational contexts, this ethnographically informed qualitative study describes how Lulu—a white, cisgender, queer secondary English language arts teacher in a rural, public school in the Midwest—discursively constructed the functions of her humor with respect to teaching, queerness, and their interrelations. Drawing on social theorizations of humor, particularly queer theorizations of humor, this article argues that Lulu described her humor as having three functions: building relationships, facilitating learning, and opening possibilities for queerness. These findings illustrate tensions in that Lulu leveraged humor to build a livable, joyous career in which she …


Life Among The Sand Grains, Will M. Ballentine, N. G. Roberts, M. K. Yap-Chiongco, K. M. Halanych, K. M. Kocot Feb 2025

Life Among The Sand Grains, Will M. Ballentine, N. G. Roberts, M. K. Yap-Chiongco, K. M. Halanych, K. M. Kocot

Biology Faculty Works

Have you ever played with sand at the beach? Did you know you were also playing with thousands of tiny animals? The sand in the ocean is home to many small creatures called meiofauna, but you can only see them under a magnifying glass or microscope. Meiofauna are so tiny that sand grains seem like boulders to them. Meiofauna are too small to move these boulders, so they wriggle through spaces between them. Living in such tight spaces has led them to evolve long, skinny body shapes like worms. They also have special body parts to grip sand grains and …


Conformation And Membrane Topology Of The N-Terminal Ectodomain Of Influenza A M2 Protein, Kyra C. Roepke , '24, Kathleen P. Howard Feb 2025

Conformation And Membrane Topology Of The N-Terminal Ectodomain Of Influenza A M2 Protein, Kyra C. Roepke , '24, Kathleen P. Howard

Chemistry & Biochemistry Faculty Works

The N-terminal ectodomain of the influenza A M2 protein is a target for universal influenza vaccine development and novel antiviral strategies. Despite the significance of this domain, it is poorly understood and most structural studies of the M2 protein have disregarded the N-terminal ectodomain in their analyses. Here, we report conformational properties and describe insights into the membrane topology of sites along the N-terminal ectodomain. Full-length M2 protein is embedded in lipid bilayer nanodiscs and studied using site-directed spin labeling electron paramagnetic resonance spectroscopy. Results are consistent with a turn in the middle of the ectodomain that changes in proximity …


Laina Farhat-Holzman: Distinguished Iscsc Author, Incisive Thinker, Fearless Commentator, Innovative Leader, Joseph Drew Feb 2025

Laina Farhat-Holzman: Distinguished Iscsc Author, Incisive Thinker, Fearless Commentator, Innovative Leader, Joseph Drew

Comparative Civilizations Review

It is a sad duty to report that a luminary who was long associated with this journal and with the leadership of the International Society for the Comparative Study of Civilizations, Dr. Laina Farhat-Holzman, has died.


Professor Christopher Berard And The Knights Of The Seminar Table, Michael Hagan Feb 2025

Professor Christopher Berard And The Knights Of The Seminar Table, Michael Hagan

Arthurian Epistolary Project (HUM 270-001)

From https://news.providence.edu/king-arthur-course/

A new course offered by Christopher Berard, Ph.D. ’07, adjunct professor of humanities, introduced students to selections in translation from the massive Lancelot-Grail Cycle of Old French prose Arthurian romances (c. 1210–30), the most comprehensive and canonical version of the Arthurian legend ever written.

The 1.5-credit course, King Arthur: Monarch of the Medieval Imagination, culminated in a creative writing project in which students composed a mock letter according to the formal conventions of medieval epistolary documents such as public acts and private letters. Each student assumed the persona of one Arthurian character, addressed the document to another …


Arginine Metabolism Is A Biomarker Of Red Blood Cell And Human Aging., Julie A Reisz, Eric J Earley, Travis Nemkov, Alicia Key, Daniel Stephenson, Gregory R Keele, Monika Dzieciatkowska, Steven L Spitalnik, Eldad A Hod, Steven Kleinman, Nareg H Roubinian, Mark T Gladwin, Kirk C Hansen, Philip J Norris, Michael P Busch, James C Zimring, Gary Churchill, Grier P Page, Angelo D'Alessandro Feb 2025

Arginine Metabolism Is A Biomarker Of Red Blood Cell And Human Aging., Julie A Reisz, Eric J Earley, Travis Nemkov, Alicia Key, Daniel Stephenson, Gregory R Keele, Monika Dzieciatkowska, Steven L Spitalnik, Eldad A Hod, Steven Kleinman, Nareg H Roubinian, Mark T Gladwin, Kirk C Hansen, Philip J Norris, Michael P Busch, James C Zimring, Gary Churchill, Grier P Page, Angelo D'Alessandro

Faculty Research 2025

Increasing global life expectancy motivates investigations of molecular mechanisms of aging and age-related diseases. This study examines age-associated changes in red blood cells (RBCs), the most numerous host cell in humans. Four cohorts, including healthy individuals and patients with sickle cell disease, were analyzed to define age-dependent changes in RBC metabolism. Over 15,700 specimens from 13,757 humans were examined, a major expansion over previous studies of RBCs in aging. Multi-omics approaches identified chronological age-related alterations in the arginine pathway with increased arginine utilization in RBCs from older individuals. These changes were consistent across healthy and sickle cell disease cohorts and …


Polyploid Superficial Uroepithelial Bladder Barrier Cells Express Features Of Cellular Senescence Across The Lifespan And Are Insensitive To Senolytics., Iman M Al-Naggar, Maria Antony, Dylan Baker, Lichao Wang, Lucas Da Cunha Godoy, Chia-Ling Kuo, Matthew O Fraser, Phillip P Smith, Ming Xu, George A Kuchel Feb 2025

Polyploid Superficial Uroepithelial Bladder Barrier Cells Express Features Of Cellular Senescence Across The Lifespan And Are Insensitive To Senolytics., Iman M Al-Naggar, Maria Antony, Dylan Baker, Lichao Wang, Lucas Da Cunha Godoy, Chia-Ling Kuo, Matthew O Fraser, Phillip P Smith, Ming Xu, George A Kuchel

Faculty Research 2025

Lower urinary tract dysfunction (LUTD) increases with aging. Ensuing symptoms including incontinence greatly impact quality of life, isolation, depression, and nursing home admission. The aging bladder is hypothesized to be central to this decline, however, it remains difficult to pinpoint a singular strong driver of aging-related bladder dysfunction. Many molecular and cellular changes occur with aging, contributing to decreased resilience to internal and external stressors, affecting urinary control and exacerbating LUTD. In this study, we examined whether cellular senescence, a cell fate involved in the etiology of most aging diseases, contributes to LUTD. We found that umbrella cells (UCs), luminal …


Intrinsic-Dimension Analysis For Guiding Dimensionality Reduction And Data Fusion In Multi-Omics Data Processing., Jessica Gliozzo, Mauricio Soto-Gomez, Valentina Guarino, Arturo Bonometti, Alberto Cabri, Emanuele Cavalleri, Justin Reese, Peter N Robinson, Marco Mesiti, Giorgio Valentini, Elena Casiraghi Feb 2025

Intrinsic-Dimension Analysis For Guiding Dimensionality Reduction And Data Fusion In Multi-Omics Data Processing., Jessica Gliozzo, Mauricio Soto-Gomez, Valentina Guarino, Arturo Bonometti, Alberto Cabri, Emanuele Cavalleri, Justin Reese, Peter N Robinson, Marco Mesiti, Giorgio Valentini, Elena Casiraghi

Faculty Research 2025

Multi-omics data have revolutionized biomedical research by providing a comprehensive understanding of biological systems and the molecular mechanisms of disease development. However, analyzing multi-omics data is challenging due to high dimensionality and limited sample sizes, necessitating proper data-reduction pipelines to ensure reliable analyses. Additionally, its multimodal nature requires effective data-integration pipelines. While several dimensionality reduction and data fusion algorithms have been proposed, crucial aspects are often overlooked. Specifically, the choice of projection space dimension is typically heuristic and uniformly applied across all omics, neglecting the unique high dimension small sample size challenges faced by individual omics. This paper introduces a …


Genomic Reanalysis Of A Pan-European Rare-Disease Resource Yields New Diagnoses., Steven Laurie, Wouter Steyaert, Elke De Boer, Kiran Polavarapu, Nika Schuermans, Anna K Sommer, German Demidov, Kornelia Ellwanger, Ida Paramonov, Coline Thomas, Stefan Aretz, Jonathan Baets, Elisa Benetti, Gemma Bullich, Patrick F Chinnery, Jill Clayton-Smith, Enzo Cohen, Daniel Danis, Jean-Madeleine De Sainte Agathe, Anne-Sophie Denommé-Pichon, Jordi Diaz-Manera, Stephanie Efthymiou, Laurence Faivre, Marcos Fernandez-Callejo, Mallory Freeberg, José Garcia-Pelaez, Lena Guillot-Noel, Tobias B Haack, Mike Hanna, Holger Hengel, Rita Horvath, Henry Houlden, Adam Jackson, Lennart Johansson, Mridul Johari, Erik-Jan Kamsteeg, Melanie Kellner, Tjitske Kleefstra, Didier Lacombe, Hanns Lochmüller, Estrella López-Martín, Alfons Macaya, Anna Marcé-Grau, Aleš Maver, Heba Morsy, Francesco Muntoni, Francesco Musacchia, Isabelle Nelson, Vincenzo Nigro, Catarina Olimpio, Carla Oliveira, Jaroslava Paulasová Schwabová, Martje G Pauly, Borut Peterlin, Sophia Peters, Rolph Pfundt, Giulio Piluso, Davide Piscia, Manuel Posada, Selina Reich, Alessandra Renieri, Lukas Ryba, Karolis Šablauskas, Marco Savarese, Ludger Schöls, Leon Schütz, Verena Steinke-Lange, Giovanni Stevanin, Volker Straub, Marc Sturm, Morris A Swertz, Marco Tartaglia, Iris B A W Te Paske, Rachel Thompson, Annalaura Torella, Christina Trainor, Bjarne Udd, Liedewei Van De Vondel, Bart Van De Warrenburg, Jeroen Van Reeuwijk, Jana Vandrovcova, Antonio Vitobello, Janet Vos, Emílie Vyhnálková, Robin Wijngaard, Carlo Wilke, Doreen William, Jishu Xu, Burcu Yaldiz, Luca Zalatnai, Birte Zurek, Solve-Rd Ditf-Genturis, Solve-Rd Ditf-Ithaca, Solve-Rd Ditf-Euro-Nmd, Solve-Rd Ditf-Rnd, Solve-Rd Consortium, Anthony J Brookes, Teresinha Evangelista, Christian Gilissen, Holm Graessner, Nicoline Hoogerbrugge, Stephan Ossowski, Olaf Riess, Rebecca Schüle, Matthis Synofzik, Alain Verloes, Leslie Matalonga, Han G Brunner, Katja Lohmann, Richarda M De Voer, Ana Töpf, Lisenka E L M Vissers, Sergi Beltran, Alexander Hoischen Feb 2025

Genomic Reanalysis Of A Pan-European Rare-Disease Resource Yields New Diagnoses., Steven Laurie, Wouter Steyaert, Elke De Boer, Kiran Polavarapu, Nika Schuermans, Anna K Sommer, German Demidov, Kornelia Ellwanger, Ida Paramonov, Coline Thomas, Stefan Aretz, Jonathan Baets, Elisa Benetti, Gemma Bullich, Patrick F Chinnery, Jill Clayton-Smith, Enzo Cohen, Daniel Danis, Jean-Madeleine De Sainte Agathe, Anne-Sophie Denommé-Pichon, Jordi Diaz-Manera, Stephanie Efthymiou, Laurence Faivre, Marcos Fernandez-Callejo, Mallory Freeberg, José Garcia-Pelaez, Lena Guillot-Noel, Tobias B Haack, Mike Hanna, Holger Hengel, Rita Horvath, Henry Houlden, Adam Jackson, Lennart Johansson, Mridul Johari, Erik-Jan Kamsteeg, Melanie Kellner, Tjitske Kleefstra, Didier Lacombe, Hanns Lochmüller, Estrella López-Martín, Alfons Macaya, Anna Marcé-Grau, Aleš Maver, Heba Morsy, Francesco Muntoni, Francesco Musacchia, Isabelle Nelson, Vincenzo Nigro, Catarina Olimpio, Carla Oliveira, Jaroslava Paulasová Schwabová, Martje G Pauly, Borut Peterlin, Sophia Peters, Rolph Pfundt, Giulio Piluso, Davide Piscia, Manuel Posada, Selina Reich, Alessandra Renieri, Lukas Ryba, Karolis Šablauskas, Marco Savarese, Ludger Schöls, Leon Schütz, Verena Steinke-Lange, Giovanni Stevanin, Volker Straub, Marc Sturm, Morris A Swertz, Marco Tartaglia, Iris B A W Te Paske, Rachel Thompson, Annalaura Torella, Christina Trainor, Bjarne Udd, Liedewei Van De Vondel, Bart Van De Warrenburg, Jeroen Van Reeuwijk, Jana Vandrovcova, Antonio Vitobello, Janet Vos, Emílie Vyhnálková, Robin Wijngaard, Carlo Wilke, Doreen William, Jishu Xu, Burcu Yaldiz, Luca Zalatnai, Birte Zurek, Solve-Rd Ditf-Genturis, Solve-Rd Ditf-Ithaca, Solve-Rd Ditf-Euro-Nmd, Solve-Rd Ditf-Rnd, Solve-Rd Consortium, Anthony J Brookes, Teresinha Evangelista, Christian Gilissen, Holm Graessner, Nicoline Hoogerbrugge, Stephan Ossowski, Olaf Riess, Rebecca Schüle, Matthis Synofzik, Alain Verloes, Leslie Matalonga, Han G Brunner, Katja Lohmann, Richarda M De Voer, Ana Töpf, Lisenka E L M Vissers, Sergi Beltran, Alexander Hoischen

Faculty Research 2025

Genetic diagnosis of rare diseases requires accurate identification and interpretation of genomic variants. Clinical and molecular scientists from 37 expert centers across Europe created the Solve-Rare Diseases Consortium (Solve-RD) resource, encompassing clinical, pedigree and genomic rare-disease data (94.5% exomes, 5.5% genomes), and performed systematic reanalysis for 6,447 individuals (3,592 male, 2,855 female) with previously undiagnosed rare diseases from 6,004 families. We established a collaborative, two-level expert review infrastructure that allowed a genetic diagnosis in 506 (8.4%) families. Of 552 disease-causing variants identified, 464 (84.1%) were single-nucleotide variants or short insertions/deletions. These variants were either located in recently published novel disease …


Prediction Of Lacosamide Concentrations To Support Dose Optimization During Pregnancy, Jessica M. Barry, Sílvia M. Illamola, Page B. Pennell, Catherine M.T. Sherwin, Kimford J. Meador, Angela K. Birnbaum Feb 2025

Prediction Of Lacosamide Concentrations To Support Dose Optimization During Pregnancy, Jessica M. Barry, Sílvia M. Illamola, Page B. Pennell, Catherine M.T. Sherwin, Kimford J. Meador, Angela K. Birnbaum

Pediatrics Faculty Publications

Objective: We aimed to quantify and predict lacosamide exposure during pregnancy by developing a pregnancy physiologically-based pharmacokinetic model, allowing the prediction of potential dose increases to support maintaining a patient's preconception lacosamide concentrations. Methods: Models for nonpregnant adults and pregnant female patients were constructed using physiochemical and pharmacological parameters identified from literature review. Evaluation of plasma concentration data from human males was digitized froM.T.he literature. Concentration data in nonpregnant and pregnant human females were available froM.T.he Maternal Outcomes and Neurodevelopmental Effects of Antiepileptic Drugs (MONEAD) study, a longitudinal observational study which followed 11 nonpregnant and 16 pregnant women receiving lacosamide. …


Dean's Research Newsletter, February 2025, Neil W. Schluger Feb 2025

Dean's Research Newsletter, February 2025, Neil W. Schluger

SOM Dean's Research Newsletter

No abstract provided.


Himmelfarb Headlines - February/March 2025, The George Washington University, Himmelfarb Health Sciences Library Feb 2025

Himmelfarb Headlines - February/March 2025, The George Washington University, Himmelfarb Health Sciences Library

Himmelfarb Headlines (2009 - present)

News, information, and resources relating to Himmelfarb Library that is of interest to patrons.


Development Of 24-Hour Rhythms In Cortisol Secretion Across Infancy: A Systematic Review And Meta-Analysis Of Individual Participant Data, Laura Kervezee, Michelle Romijn, Kirsten N.G. Van De Weijer, Britney S.J. Chen, George L. Burchell, Marieke S. Tollenaar, Marcela Tamayo-Ortiz, Lauren E. Philbrook, Carolina De Weerth, Yang Cao, Joost Rotteveel, Rina D. Eiden, Rima Azar, Nicole R. Bush, Adina Chis, Grazyna Kmita, Melissa W. Clearfield, Roseriet Beijers, Michael Gröschl, Stefan A. Wudy, Andries Kalsbeek, Evalotte Mörelius, Martijn J.J. Finken Feb 2025

Development Of 24-Hour Rhythms In Cortisol Secretion Across Infancy: A Systematic Review And Meta-Analysis Of Individual Participant Data, Laura Kervezee, Michelle Romijn, Kirsten N.G. Van De Weijer, Britney S.J. Chen, George L. Burchell, Marieke S. Tollenaar, Marcela Tamayo-Ortiz, Lauren E. Philbrook, Carolina De Weerth, Yang Cao, Joost Rotteveel, Rina D. Eiden, Rima Azar, Nicole R. Bush, Adina Chis, Grazyna Kmita, Melissa W. Clearfield, Roseriet Beijers, Michael Gröschl, Stefan A. Wudy, Andries Kalsbeek, Evalotte Mörelius, Martijn J.J. Finken

Research outputs 2022 to 2026

Context: In adults, cortisol levels show a pronounced 24-hour rhythm with a peak in the early morning. It is unknown at what age this early-morning peak in cortisol emerges during infancy, hampering the establishment of optimal dosing regimens for hydrocortisone replacement therapy in infants with an inborn form of adrenal insufficiency. Objective: We aimed to characterize daily variation in salivary cortisol concentration across the first year of life. Methods: We conducted a systematic review followed by an individual participant data meta-analysis of studies reporting on spontaneous (ie, not stress-induced) salivary cortisol concentrations in healthy infants aged 0-1 year. A one-stage …


Genome Wide Association Study Reveals Novel Associations With Face Morphology, Aamer Alshehhi, Mira Mousa, Guan K. Tay, Naoufel Werghi, Habiba Alsafar Feb 2025

Genome Wide Association Study Reveals Novel Associations With Face Morphology, Aamer Alshehhi, Mira Mousa, Guan K. Tay, Naoufel Werghi, Habiba Alsafar

Research outputs 2022 to 2026

Genome-wide association studies (GWAS) on the Middle Eastern population, including the United Arab Emirates (UAE), have been relatively limited. The present study aims to investigate genotype-face morphology associations in the UAE population through Genome Wide Association Studies (GWAS). Phenotypic data (44 face measurements) from 172 Emiratis was obtained through three-dimensional (3D) scanning technology and an automatic face landmarking technique. GWAS analysis revealed associations of 19 genetic loci with six face features, 14 of which are novel. The GWAS analysis revealed 11 significant relationships between 44 face parameters and 242 SNPs, exceeding the GWAS significance threshold. These phenotypes were previously associated …


Analytical Method For Solving Systems Of Fractional Initial Value Problems Using The Modified Atangana-Baleanu Derivative, Lana Mohammad Aref Feb 2025

Analytical Method For Solving Systems Of Fractional Initial Value Problems Using The Modified Atangana-Baleanu Derivative, Lana Mohammad Aref

Theses

This thesis presents an analytical method to solve systems of fractional initial value problems using the Modified Atangana-Baleanu Fractional Derivative. The proposed approach leverages an improved operational matrix method, incorporating an iterative, direct computation technique to simplify the solution process and reduce computational costs. Foundational concepts in fractional calculus and block pulse functions are introduced, followed by the derivation of operational matrices tailored for fractional systems. Theoretical analysis establishes the existence and uniqueness of solutions, along with uniform convergence and error estimates. Practical examples and applications are presented that demonstrate the efficiency, accuracy, and versatility of the method in solving …


Campus Chronicle, Lara Jones, Katie Hirth, Jayden Park, Kiofwe Kapepula, Joyanna Huang, Jaedyn Henry, Isaiah Cardines, Samantha Russell, Derek Jensen, Andy Langager Feb 2025

Campus Chronicle, Lara Jones, Katie Hirth, Jayden Park, Kiofwe Kapepula, Joyanna Huang, Jaedyn Henry, Isaiah Cardines, Samantha Russell, Derek Jensen, Andy Langager

Campus Chronicle

No abstract provided.


Student-Conscious Practice And Pathways For Student Success, Anthony Walker, Sara Mata Feb 2025

Student-Conscious Practice And Pathways For Student Success, Anthony Walker, Sara Mata

Journal of Research Initiatives

This paper shares evidence of how four programs enhanced students' pathways from high school through bachelor's degrees. Each program expanded students' networks, fostered a sense of belonging, and developed critical thinking skills. Ten years after participation, we looked back to gain insights into key elements that impacted students' learning experience. Data from student voices highlighted the importance of inclusiveness in action, institutional responsibility, and culturally relevant pedagogy in student success and program impact.


The Impact Of Working With Forced Migrants In The Context Of Graduate Research Training, Alfonso Mercado, Frances R. Morales, Amanda Palomin, Andy U. Torres, Amanda Venta Feb 2025

The Impact Of Working With Forced Migrants In The Context Of Graduate Research Training, Alfonso Mercado, Frances R. Morales, Amanda Palomin, Andy U. Torres, Amanda Venta

Psychological Science Faculty Publications

Researchers, including graduate students, who work with refugees and asylum seekers are exposed to narratives of torture, trauma, loss, and distress. This article features the testimonies of the authors as doctoral students and mental health researchers-in-training—as well as their supervisors—regarding their research with the immigrant community in an underserved area on the Texas U.S.–Mexico border, a popular migratory entry point for Central American immigrants seeking asylum in the United States. This article aimed to bear witness to the emotional impact that working with forced migrants may have on researchers by describing the experiences of doctoral students conducting research with asylum …


Males Differ More Between Developmental Stages Than Females, And Plasticity To Light Is Stage-Dependent In The Tropical Plant Marchantia Inflexa, Jonathan D. Moore, D. Nicholas Mcletchie Feb 2025

Males Differ More Between Developmental Stages Than Females, And Plasticity To Light Is Stage-Dependent In The Tropical Plant Marchantia Inflexa, Jonathan D. Moore, D. Nicholas Mcletchie

Biology Faculty Publications

Plants have evolved strategies to maintain photosynthesis and mitigate tissue-damaging high light. In some dioecious seed plants, these strategies are sexually dimorphic and are linked to spatial segregation of the sexes (SSS) along light gradients. In vascular tissue-free plants (bryophytes) with separate sexes, SSS is common, but how light gradients, sexual dimorphisms, and SSS correlate is not well understood. To test if sexual dimorphisms in vegetative or sexual stages lead to light-associated SSS in bryophytes, we used Marchantia inflexa whose males occupy a wider range of light conditions, including higher light conditions, than females. We also tested if changes in …