Digital Commons Network^™

Norovirus Co-Opts Ninj1 For Selective Protein Secretion, Jaewon Song, Wandy L Beatty, Anthony Orvedahl, Et Al.

2020-Current year OA Pubs

Plasma membrane rupture by Ninjurin-1 (NINJ1) executes programmed cell death, releasing large cellular damage-associated molecular patterns (DAMPs). However, the regulation and selectivity of NINJ1-mediated DAMP release remain unexplored. Here, we uncover that murine norovirus (MNoV) strategically co-opts NINJ1 to selectively release the intracellular viral protein NS1, while NINJ1-mediated plasma membrane rupture simultaneously bulk-releases various cellular DAMPs. Host caspase-3 cleaves the precursor NS1/2, leading to NS1 secretion via an unconventional pathway. An unbiased CRISPR screen identifies NINJ1 as an essential factor for NS1 secretion. During infection, NINJ1 is recruited to the viral replication site, where it oligomerizes and forms speckled bodies, …

Simultaneous Detection Of Escherichia Coli And Agrobacterium Tumefaciens By Using Gold Nanoparticle Enhanced Polymerase Chain Reaction, Xinyi Zhao, Baljit Singh, Christine O’Connor, Hugh J. Byrne, Furong Tian

Research Outputs: 2025-Present

No abstract provided.

Iegenes: A Machine Learning Method For Selecting Differentially Expressed Genes In Cancer Studies, Xiao-Lei Xia, Shang-Ming Zhou, Yunguang Liu, Na Lin, Ian Overton

School of Nursing and Midwifery

Gene selection is crucial for cancer classification using microarray data. In the interests of improvingcancer classification accuracy, in this paper, we developed a new wrapper method called ieGENES for geneselection. First we proposed a parsimonious kernel machine regularization (PKMR) model by usingridge regularization in kernel machine driven classification to tackle multi-collinearity for the sake of stableestimates in high-dimensional settings. Then the ieGENES algorithm was developed to optimally identifyrelevant genes while iteratively eliminating redundant ones based on leave-one-out cross-validation accuracy.In particular, we developed a new methodology to optimally update model parameters upon gene removal.The ieGENES algorithm was evaluated on six cancer …

Chronic Disease In Hispanics Nationally And In States Neighboring The Border: What Can We Learn From All Of Us Database?, Abdallah Galal, Bassent Abdelbary

Research Symposium

Background: Chronic diseases pose significant health challenges with higher impact on specific demographic groups in the United States. Hispanics face a disproportionate burden of chronic diseases compared to non-Hispanic whites, experiencing higher rates of conditions such as obesity, diabetes, renal and cardiovascular diseases. This health disparity can be attributed to various factors, including socioeconomic status, cultural influences, access to healthcare, acculturation, and genetic predisposition. The purpose of this study is to investigate the prevalence and burden of diabetes, hypertension, and chronic kidney disease within the Hispanic/Latino population in the United States, assess biological and sociodemographic risk factors, and analyze disparities …

Volume 32-2 Complete Issue, C. Nicholas Raphael

The Geographical Bulletin

Volume 32-2 Complete Issue

Editorial Comments Facilitating Field Research, H. J. De Blij

The Geographical Bulletin

All of us remember the favorite sayings of some of our teachers. When I was a first-year student at the University of the Witwatersrand, Professor J. H. Wellington would start many a lecture by stating "Geography is a field science. What I am about to tell you comes from my field notes. When you go on to graduate school, your success or failure will depend on your ability to do original field research." When I was in the Master's degree program at Northwestern University, a visiting professor, A. E. Moodie, liked to say that "If you cannot map it, it …

Editorial Comments Geography And Yesteryear, Geoffrey J. Martin

The Geographical Bulletin

Have you noticed how we revere what is new? A new scholarly book, a new text book, a new article, a new idea, a new assessment, a new terminology all seem to readily command our attention. This is not surprising for we live in a society which places a premium on what is new; and what is new is considered best. Now such an evaluation is probably legitimate for the accumulative sciences ... mathematics, physics, chemistry, biology. It is eminently not true for art, music and literature; Leonardo da Vinci and Rembrandt, Mozart and Tchaikovsky, Chaucer and Shakespeare, each speak …

Track 2: Panel Discussion: Strategies For Career Advancement In Higher Education, Tonyalle Rush, Natalie W. Gaughf, Christy Riddle, Tanya Kelly-Kirk, Bethany Mills, Jess Turuc

WHEMN Conference

This panel discussion will focus on practical steps for career growth, including mentorship, professional development opportunities, and effective self-promotion.<.p>

• Tonyalle Rush, Vice President For Student And Enrollment Management, Northwest Community College — Moderator
• Natalie W. Gaughf, Associate Vice Chancellor for Academic Affairs, University of Mississippi Medical Center
• Christy Riddle, Chief Marketing Officer, Delta State University
• Tanya Kelly-Kirk, Associate Vice President for Physical Plant Director & Special Projects, Rust College
• Bethany Mills, Executive Director of the Career Center, Mississippi State University
• Jess Turuc, Director of Fraternity and Sorority Life, The University of Mississippi

Current Challenges And Preliminary Morphological Reassessment Of The Genus Chaerilus Simon, 1877 In China (Scorpiones: Chaerilidae), Victoria Tang

Euscorpius

The genus Chaerilus Simon, 1877 in China is preliminarily revised on a morphological basis, derived from the available literature and newly examined specimens. The robustness of several commonly applied species-level diagnostic criteria are evaluated. Ten species are provisionally recognized for China, including one new morphospecies, Chaerilus herta sp. n., described from 9 females, 40 males, and 2 juvenile females collected in Mêdog County. The current study only reveals and resolves several most elementary issues in the taxonomy of Chinese Chaerilus. Further molecular investigations are warranted until topotypes of certain species become available.

Metacognitive Awareness And Learning Approaches Among Graduate Students, Yuewei Shi, Leslie Cordie

Journal of Graduate Education Research

This study explored the relationship between metacognitive awareness and learning approaches in two groups of graduate students: direct-pathway students and adult graduate students. Direct-pathway students transitioned directly from their undergraduate programs to graduate school, while adult graduate students had delayed entry, typically after age 25 and after working for several years. To investigate differences between the two groups, we utilized a self-reported survey incorporating the Metacognitive Awareness Inventory (MAI) and the Study Skills Inventory for Students (ASSIST). Survey data was analyzed to determine if the groups differed in their metacognitive awareness and learning approaches. The findings revealed that adult graduate …

Plasma Levels Of Mir-21b And Mir-146a Can Discriminate Rheumatoid Arthritis Diagnosis And Severity., Rizk S. Sarhan, Amr M El-Hammady, Yasmin M Marei, Sania K Elwia, Doaa M Ismail, Emtethal As Ahmed

BioMedicine

Objectives: This study tried to examine the ability of the estimated plasma gene-expression levels (PGEL) of microRNA (miR)-146a and miR-21b to distinguish patients with early rheumatoid arthritis (RA) out of arthritis patients who did not fulfill the diagnostic spectrum of either RA or osteoarthritis (OA); the diagnostic Gray-Zone (GZ).

Patients & Methods: Enrolled patients underwent full diagnostic workup and were categorized as highseropositive and fulfilled the diagnostic spectrum for RA (RA-group), seronegative and fulfilling the diagnostic spectrum of OA (OA-group) and low-seropositive or seronegative patients who did not fulfill diagnostic criteria of RA or OA (GZ-group). Blood samples were obtained …

In-Silico Study Of Rosmarinic Acid Roles In Inhibiting Breast Cancer Progression, Ngakan Putu Krishna Mahayana, Ngurah Bagus Agung Surya Nanda Jayesvara Dwi Sutanegara, Made Dwinanda Prabawa Mahardana, Desak Made Wihandani

BioMedicine

Background: Breast cancer is the highest cancer incidence in the world. Chemotherapy is currently one of the main breast cancer treatments besides surgery. It is capable of evolving to become resistant to chemotherapy agents. Chemotherapy also has significant side effects. Rosmarinic acid could become an anti-cancer agent candidate for the treatment of breast cancer, but its molecular mechanism is still unclear.

Aim: This study aimed to clarify the molecular mechanism of rosmarinic acid anti-breast cancer properties via an in-silico study.

Methods: Web-based screening tools such as SwissTargetPrediction, Similarity Ensemble Approach (SEA), and TargetNet were used as initial screening. From web-based …

Unveiling Role Of Oncogenic Signalling Pathways In Complicating Breast Cancer, Acharya Balkrishna, Sagar Kumar, Rohan Malik, Kuldeep Singh Mehra, Hariom Chaturvedi, Okeshwar Okeshwar, Rashmi Mittal

BioMedicine

Heterogeneous nature of breast cancer has significantly affected the overall survival, disease free survival and progression free survival amongst the diseased individuals. Metastasis of cancerous cells to distant sites including bone, lungs, liver, lymph node and others have further exhilarated the adverse effects. However, ER, PR and HER-2 are responsible for normal physiological development of women but in altered conditions they may act as initiator or progressor and so far 5 subtypes of disease have been identified. Alteration of pro-survival, pro-proliferative and anti-apoptotic pathways including JAK/STAT, MAPK,

PI3K/AkT/mTOR, NF-κB, BCL2 and several others have induced oncogenic events including epithelial-mesenchymal transition, …

The Chanticleer, 2025-02-27, Coastal Carolina University

The Chanticleer Student Newspaper

The editorially independent student produced weekly newspaper of Coastal Carolina University.

Standing To Enforce The Future: Citizen Suits And Climate Change, Jordan Budd, Margaret Sova Mccabe

Law Faculty Scholarship

This Article takes as its starting point the premise that Congress, facing an existential climate catastrophe, might choose to impose direct and significant restrictions on greenhouse gas (GHG) emissions. Were it to do so, federal policy would require powerful enforcement mechanisms to reach the myriad emission sources fueling the nation’s vast contribution to global warming.

Among the most potent and far-reaching enforcement tools available to Congress are citizen suits—actions brought by private litigants to enforce federal regulations and to hold agencies accountable for related inaction. Private enforcement in the context of climate change, however, faces a nearly insurmountable barrier—Article III …

Perceptions Of Using Exercise As A Self-Determining Motivational Strategy For Gen Z Females With Depression Since Covid-19., Andrea Menhennet

Walden Dissertations and Doctoral Studies

The COVID-19 pandemic significantly disrupted individuals' daily routines, which amplified mental health challenges worldwide. A demographic highly prone to depression is Gen Z females. They faced unique struggles during this period, specifically managing their well-being. This study explored the perceptions of Gen Z females with depression regarding the use of exercise as a motivational strategy based on self-determination theory (SDT). The study aimed to understand how physical activity and ways to cope were allocated to manage mental health struggles, focusing on autonomy, competence, and relatedness as pertinent psychological needs. Using the generic qualitative approach, eight female Gen Z participants shared …

Factor Structure And Longitudinal Changes In Bilinguals’ Oral Narratives Production: Role Of Language Exposure, Language-Domain Proficiency, And Transfer, Joseph Hin Yan Lam, Molly Ann Leachman, Cecilia Del Carmen Perez, Amy S. Pratt, Elizabeth D. Peña, Lisa M. Bedore, Ronald B. Gillam

Communicative Disorders and Deaf Education Faculty Publications

This paper examined the interaction between narrative performance, language exposure, and standardized measures of morphosyntax and semantics, in bilingual children tested two times, 1 year apart. We aimed to 1) identify the factor structure of oral narrative measures, and 2) examine the direction and strength of the effects of (i) language exposure and (ii) the relationship between language domains and narrative production. A total of 143 Spanish (L1)-English (L2) bilingual children completed a battery of oral narrative and oral language proficiency assessments in Spanish and English at two time points (kindergarten and Grade 1). Factor analyses yielded an identical two-factor …

Curriculum Minutes 02/27/2025, Curriculum Committee

Curriculum Committee Minutes

No abstract provided.

Conquer And Prevail Issue 182 February 27 2025, Wofford College. Office Of Marketing And Communications

Conquer and Prevail Newsletter

No abstract provided.

The Perspective Of African American Single Mothers In Birmingham, Alabama On The Criminalization Of African American Male Adolescents, Jessica Ruth Whiteside

Walden Dissertations and Doctoral Studies

The purpose of this qualitative study was to explore the lived experiences of single African American mothers raising males and their association with criminal behavior. The nature of this research was phenomenological. This cross-sectional study, informed by the general strain theory, explored the effects of stress and strain from adversity and systematic racism on the criminality of African American male adolescents. The key research question was: In what ways do African American single mothers view their part and the part of their socio-economic context as contributing to the criminalization of their sons? A phenomenological research approach was used, and the …

University Philharmonic Orchestra & Chamber Ensembles

Bailey School of Music Concert Programs

University Philharmonic Orchestra

Nancy Conley, Conductor

Chamber Ensembles

Machinery Imbalance Failure Prediction Based On Pump – Motor Vibration Readings, Abdulrahman Albuflaseh

Theses

Predictive maintenance has emerged as a transformative solution in industrial operations, reducing unexpected machine failures and minimizing downtime. This study explores the application of machine learning in vibration analysis to detect imbalances in pump-motor units, a critical issue that accelerates equipment wear and increases maintenance costs. Traditional maintenance methods, such as scheduled inspections, often fail to identify faults early, leading to significant operational disruptions, particularly in utility, oil and gas sectors. By leveraging real-time vibration data and advanced machine learning techniques, this research aims to develop an efficient imbalance detection model that enhances maintenance efficiency and reliability. The study employs …

Executive Functioning, Diabetes Distress, And Diabetes Management Among Adolescents With Type 1 Diabetes: Youth And Parent Perspectives, Allison Choe, Emily M. Fredericks, Dana L. Albright, Joyce M. Lee, Julie M. Sturza, Hurley O. Riley, Niko Kaciroti, Katherine W. Bauer, Allison L. Miller

Health Services and Informatics Research

Objective: Most adolescents with Type 1 Diabetes (T1D) do not achieve recommended glycemic targets, placing them at risk for long-term complications. Executive functioning (EF), or the cognitive processes that support goal-directed action and management of behavior, emotion, and cognition, is proposed to support effective T1D management and contribute to glycemic stability. We sought to examine associations of EF with T1D management behaviors and diabetes-related distress in adolescents with T1D.

Methods: Participants were 13–17-year-olds (M = 15.44, SD = 1.38 years) from a randomized controlled trial (N = 88). We conducted secondary analyses of preintervention data. Youth and their …

The Lungs Of The Finch: Three-Dimensional Pulmonary Anatomy Of The Zebra Finch (Taeniopygia Castanotis), Aracely Martinez, Raul E. Diaz, Clinton A. Grand Pre, Brandon P. Hedrick, Emma R. Schachner

School of Graduate Studies Faculty Publications

The avian respiratory system has been an area of biological interest for centuries, with zebra finches (Taeniopygia castanotis) emerging in recent decades as a primary avian model organism popularized across numerous disciplines. The pulmonary system of birds is unique in that air moves unidirectionally through the gas-exchanging lung, and previous works have suggested anatomical constraints within the bronchial network that may be coupled to the inspiratory valving mechanism in Aves. We used µCT-based segmented models to visualize and describe the morphology of the zebra finch lower respiratory system and to examine intra- and interspecific differences of the bronchial tree with …

Female Students With Disabilities’ Perceptions Of Science, Technology, Engineering, Mathematics Education, Toni Anne Walkowiak

Walden Dissertations and Doctoral Studies

The demand to increase enrollment in science, technology, engineering, and mathematics (STEM) education programs has intensified globally since the early 21st century. Researchers have concentrated on the gender divide with limited research on female students with disabilities (FSwDs). The purpose of this qualitative study was to explore FSwDs’ perceptions of their successes and challenges with accessibility, inclusion, and support experienced in STEM education programs, as well as their recommendations for improving policies and practices in STEM higher education. The study was grounded in social identity and social learning theories. For this basic qualitative design, semistructured interviews were conducted with nine …

Kedrec-Lm: A Knowledge-Distilled Explainable Drug Recommendation Large Language Model, Kai Zhang, Rui Zhu, Shutian Ma, Jingwei Xong, Yejin Kim, Fabricio Murai, Xiaozhong Liu

Faculty, Staff and Student Publications

Drug discovery is a critical task in biomedical natural language processing (NLP), yet explainable drug discovery remains underexplored. Meanwhile, large language models (LLMs) have shown remarkable abilities in natural language understanding and generation. Leveraging LLMs for explainable drug discovery has the potential to improve downstream tasks and real-world applications. In this study, we utilize open-source drug knowledge graphs, clinical trial data, and PubMed publications to construct a comprehensive dataset for the explainable drug discovery task, named \textbf{expRxRec}. Furthermore, we introduce \textbf{KEDRec-LM}, an instruction-tuned LLM which distills knowledge from rich medical knowledge corpus for drug recommendation and rationale generation. To encourage …

Carnival, Ritual, And Race-Thinking In The Bolivian Andes, Ximena Cordova, Adhemar Mercado

All Works

This paper explores the intersection of race, religion, and colonial legacies through the lens of the Oruro Carnival, examining its role in shaping Bolivian identity. Critical religion scholars argue that the entanglement of race and religion is a product of Western modernity and colonialism, which has influenced both historical and contemporary power relations. This framework is applied to analyse the Carnival, where religious practices and festive performances intersect, reflecting colonial efforts at religious conversion and racial categorisation. By focusing on the ethnography of Oruro’s embodied festive practices, this study investigates how the Carnival contributes to the construction of difference amid …

Carnival, Ritual, And Race-Thinking In The Bolivian Andes, Ximena Cordova, Adhemar Mercado

All Works

This paper explores the intersection of race, religion, and colonial legacies through the lens of the Oruro Carnival, examining its role in shaping Bolivian identity. Critical religion scholars argue that the entanglement of race and religion is a product of Western modernity and colonialism, which has influenced both historical and contemporary power relations. This framework is applied to analyse the Carnival, where religious practices and festive performances intersect, reflecting colonial efforts at religious conversion and racial categorisation. By focusing on the ethnography of Oruro’s embodied festive practices, this study investigates how the Carnival contributes to the construction of difference amid …

Interim Estimates Of 2024-2025 Seasonal Influenza Vaccine Effectiveness - Four Vaccine Effectiveness Networks, United States, October 2024-February 2025., Aaron M. Frutos, Seana Cleary, Emily L. Reeves, Haris M. Ahmad, Ashley M. Price, Wesley H. Self, Yuwei Zhu, Basmah Safdar, Ithan D. Peltan, Kevin W. Gibbs, Matthew C. Exline, Adam S. Lauring, Sarah W. Ball, Malini Desilva, Sara Y. Tartof, Kristin Dascomb, Stephanie A. Irving, Nicola P. Klein, Brian E. Dixon, Toan C. Ong, Ivana A. Vaughn, Stacey L. House, Kiran A. Faryar, Mary Patricia Nowalk, Manjusha Gaglani, Karen J. Wernli, Vel Murugan, Olivia L. Williams, Rangaraj Selvarangan, Geoffrey A. Weinberg, Mary A. Staat, Natasha B. Halasa, Leila C. Sahni, Marian G. Michaels, Janet A. Englund, Marie K. Kirby, Diya Surie, Fatimah S. Dawood, Benjamin R. Clopper, Heidi L Moline, Ruth Link-Gelles, Amanda B. Payne, Elizabeth Harker, Kristina Wielgosz, Zachary A. Weber, Duck-Hye Yang, Nathaniel M. Lewis, Jennifer Decuir, Samantha M. Olson, Jessie R. Chung, Brendan Flannery, Lisa A. Grohskopf, Carrie Reed, Shikha Garg, Sascha Ellington, Cdc Influenza Vaccine Effectiveness Collaborators

Manuscripts, Articles, Book Chapters and Other Papers

Annual influenza vaccination is recommended for all persons aged ≥6 months in the United States. Interim influenza vaccine effectiveness (VE) was calculated among patients with acute respiratory illness-associated outpatient visits and hospitalizations from four VE networks during the 2024-25 influenza season (October 2024-February 2025). Among children and adolescents agedyears, VE against any influenza was 32%, 59%, and 60% in the outpatient setting in three networks, and against influenza-associated hospitalization was 63% and 78% in two networks. Among adults aged ≥18 years, VE in the outpatient setting was 36% and 54% in two networks and was 41% and 55% against hospitalization …

Complement Activity And Autophagy Are Dysregulated In The Lungs Of Patients With Nonresolvable Covid-19 Requiring Lung Transplantation, Pooja Shivshankar, Stacey L Mueller-Ortiz, Aleksey Y Domozhirov, Weizhen Bi, Scott D Collum, Marie-Francoise Doursout, Manish Patel, Isabella N Lefebvre, Bindu Akkanti, Simon Yau, Howard J Huang, Rahat Hussain, Harry Karmouty-Quintana

Faculty, Staff and Student Publications

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-induced coronavirus disease 2019 (COVID-19) pandemic has challenged the current understanding of the complement cascade mechanisms of host immune responses during infection-induced nonresolvable lung disease. While the complement system is involved in opsonization and phagocytosis of the invading pathogens, uncontrolled complement activation also leads to aberrant autophagic response and tissue damage. Our recent study revealed unique pathologic and fibrotic signature genes associated with epithelial bronchiolization in the lung tissues of patients with nonresolvable COVID-19 (NR-COVID-19) requiring lung transplantation. However, there is a knowledge gap if complement components are modulated to contribute to tissue …