Digital Commons Network^™

Ormeloxifene-Mediated Attenuation Of Β-Catenin Signaling In Hepatocellular Carcinoma Progression, Mohammed Sikander, Shabnam Malik, Daniel Zubieta, Anyssa Rodriguez, Molly Vela, Sheema Khan, Fathi T. Halaweish, Murali M. Yallapu, Meena Jaggi, Subhash C. Chauhan

Research Symposium

Background: Hepatocellular carcinoma (HCC) is the most prevalent form of primary liver cancer, with approximately 41,000 new cases and 29,000 deaths annually in the U.S. The management of HCC poses significant challenges due to severe toxicity and inadequate responses to existing chemotherapeutic agents. Aberrant β-catenin signaling is recognized as a crucial factor influencing the differentiation grades of HCC patients. Therefore, there is an urgent need to identify more effective and non-toxic β-catenin inhibitors for cancer treatment. Notably, ormeloxifene (ORM), a clinically approved selective estrogen receptor modulator with a favorable therapeutic index, has demonstrated remarkable anticancer activity, making it a promising …

The Science Of Tattoos, Isabel Dilandro

Osmosis Magazine

From face paint to temporary stick-on tattoos, children are taught that art on bodies is something beautiful and playful, associated with memories of fun and joy. Why is it then that tattoos get such an infamous reputation? The answer is pretty simple: tattoos are not temporary. But why? How does the ink get there? How does it stay put? In order to understand this process a bit more, it is important to have a basic understanding of the skin’s structure and function.

Late! I’M Late For A Very Important Physics Update I’M Late! I’M Late For A Very Important Physics Update, Caterina Erdas

Osmosis Magazine

Modern physics is my only class where half the students are consistently late. It’s not a forgivable one or two minutes late, but five to fifteen. I say this as a culprit myself; I slept in late on the third day of class and didn’t go. It’s ironic, considering we spend a good portion of lecture re-defining time.

A Creature That Has Seen It All, Dusan Vukcevic

Osmosis Magazine

What if there was a creature that is so indecisive about its habitat, that it decides to live both in rainforests and in the Antarctic? What if this creature was taking a swim in the Mariana Trench, and warming itself up at the bottom of a mud volcano? Their appearance gave them many names, so today we call them water bears, moss piglets or simply, Tardigrades. Be that as it may, the number of their names is negligible compared to the number of harsh conditions they are able to withstand. Just how resilient are these creatures?

Osmosis Magazine - Fall 2021

Osmosis Magazine

Osmosis is a student read, led, and written publication from the University of Richmond, focusing on all aspects of healthcare and science.

Georgia Academy Of Science 2025 Annual Meeting Program, Paul Arnold, Jennifer Schroeder, Linda Jones, Andrea Kwiatkowski, Brian Hoffman, Amy L. Boggan, Lauren Albin

Georgia Journal of Science

Program for the 2025 GAS Annual Meeting.

Nursing Now, 2011, Vol 10 Iss 1, Advocate Health - Midwest

Historical Documents - Combined

Advocate Christ Medical Center and Hope Children's Hospital, Oak Lawn, IL: Internal newsletter publication written by nurses for nurses and published 6 times a year (bi-monthly). The mission of NURSING Now was to communicate, educate and motivate CMC nursing professionals towards continued excellence.

The Vulnerability Of The Heart During Diarrhea: A Case Report On Pericarditis Linked To Inflammatory Bowel Disease, Phani Bhavana Cherukuri, Jayasree Ravilla, Siva Naga S. Yarrarapu, Penny Turtel, Du Doantrang

Journal of Community Hospital Internal Medicine Perspectives

Introduction: Inflammatory bowel disease (IBD), encompassing ulcerative colitis (UC) and Crohn's disease, often involves extraintestinal manifestations, affecting up to 40% of patients. Cardiovascular complications, although rare, can include pericarditis, the most common cardiac manifestation in IBD.

Case Presentation: We report the case of a 34-year-old male with a long-standing history of UC who presented with pleuritic chest pain, shortness of breath, and worsening colitis symptoms. This case is particularly noteworthy due to the complexity added by the patient's 24-year history of UC, diverse treatment modalities (including mesalamine, 6-mercaptopurine, infliximab, vedolizumab, upadacitinib, and ustekinumab), and the patient not being on any …

Biomolecular Science, University Of Mississippi. Biomolecular Sciences

Annual Poster Session 2024-2025

Our mission is to drive innovation through combined excellence in the disciplines of Pharmacognosy, Medicinal Chemistry, Pharmacology, and Environmental Toxicology in order to understand and improve human and environmental health. We provide positive impacts to our school, the state of Mississippi, and the world, via education and mentored research at the undergraduate, graduate, and postdoctoral levels, and through our leadership in interdisciplinary chemical and biological sciences.

The Student Movement Volume 109 Issue 17: Stay Strong And March On: Spring Break Is Only One Week Away, Ayanda Dewa, Andrew Francis, Melanie Webb, Anna Rybachek, Nora Martin, Lexie Dunham, Madison Vath

The Student Movement V. 109 (2024-2025)

HUMANS

A Voice for the People: Alyssa Caruthers' Plans for Presidency, Ayanda Dewa

AUSA Social Affairs VP Wins Another Year of Service, Andrew Francis

ARTS & ENTERTAINMENT

Andrews Composers Concert 2025: An Insider's View

The Winners (and Losers) of the 97th Academy Awards, Melanie Webb

NEWS

History of Our Prillwitz Mammoth, Anna Rybachek

AUSA Cabinet Election Results Revealed for '25-'26 School Year, Andrew Francis

PULSE

A Beginner's Guide to Graduate School Applications, Nora Martin

Students React to Change of Venue for Andrews Graduation, Nora Martin

Lexie's Spring Clean, Lexie Dunham

The Black Walnut Crisis: Why are we cutting down our …

The Fierce Green Fire: Vol. 15 Issue 7, Wofford College Environmental Studies Program

The Fierce Green Fire

No abstract provided.

Lgbtq+ Identity Development And Individual Vs Group Psychotherapy Experience: A Consensual Qualitative Analysis, Aileen Marie Rands

Theses and Dissertations

Multicultural topics, such as LGBTQ+ experience, have accrued predominance within the field of psychology. It has become clear that better understanding minority experience is of utmost importance. Pervasive stigma, discrimination, and mistreatment culminate into minority stress; thus LGBTQ+ individuals face greater risk for poor mental health and seek out psychotherapy at higher rates. Despite this reality, limited psychotherapy research exists in this area generally and essentially no research has looking into the experience of LGBTQ+ individuals in group therapy. The current study investigated experiences of LGBTQ+ clients who have participated in both individual and group psychotherapy. Eleven participants were interviewed …

Medical School Watercooler Newsletter - March 7, 2025, Lindsay Hughes

Watercooler Newsletter

This is the Friday, March 7, 2025 edition of the Frederick P. Whiddon College of Medicine's newsletter -- Watercooler.

Contents include:

• Graduate Research Forum set for April 1
• GHHS celebrates Thank a Resident Day
• Students planning reproductive health fair at Mobile community center
• USA Center for Lung Biology hosts first ReSPIRE conference
• Three USA Health physicians selected for national honor medical society

Corrigendum To “ Phylogenomics Of The Tribe Leonureae Reveals A New Genus: Paraleonurus (Lamiaceae, Lamioideae) , [Turkish Journal Of Botany 48 (Si-1) 2024 427-440] “, Mei-Lin Qian, Ya-Ping Chen, Tuncay Di̇rmenci̇, Yue Zhao, Guo-Xiong Hu, Fei Zhao, Ferhat Celep, Bo Li, Chunlei Xiang

Turkish Journal of Botany

This corrigendum is written to correct an error in our previous publication. The term “ Yi Mu Cao Shu (益母草属; Chinese name).” was incorrectly spelled as “Jia Yi Mu Cao Shu (假益母草属; Chinese name)” in the article. The correct term should be “Yi Mu Cao Shu (益母草属; Chinese name)”. The authors apologize for any inconvenience caused and state that the scientific conclusions are unaffected.

Link to the original article: https://doi.org/10.55730/1300-008X.2825

Ai-Powered Education: Innovative Teaching Strategies To Elevate Student Learning, Karen J. Magruder, Ann M.L. Cavallo, Andrew M. Clark

Mavs Open Press Open Educational Resources - Archive

AI-Powered Education is a practical teaching resource crafted by educators, for educators, focusing on the integration of AI to enhance student learning. The book provides a collection of practical, step-by-step activities from a variety of disciplines in higher education. Each activity integrates AI tools and technologies into the classroom in innovative ways, with detailed guidance for instructors to seamlessly adopt these ideas.

Kylee Morris, Of Morehead City, N.C. Crowned Miss Gardner- Webb 2025, Office Of University Communications, Chloe Cloutier

Gardner-Webb NewsCenter Archive

Kylee Morris, a junior biology major, was recently crowned Miss Gardner- Webb 2025 for her outstanding musical ability and stage presence. Performing a four-mallet marimba solo of “Ghost Garden,” by Adam Hopper, she impressed the judges and audience.

Enhancing The Immunogenicity Of Extracellular Vesicle-Based Vaccines Against Pathogenic Nthi Bacteria, Christina Ciko

Theses

Acute otitis media (AOM), or ear infections, are highly prevalent in children, with nearly 80% experiencing at least one AOM by the age of three. As such, there is an urgent need for a vaccine against Nontypeable Haemophilus influenzae (NTHi), a main cause of AOM in the US. Most vaccines contain multiple antigens from the pathogen, inducing an immune response and antibodies to those antigens. Here, we describe a novel approach to creating a vaccine against NTHi, incorporating a unique recombinant trivalent protein (Tri) featuring three NTHi antigens (OMP26, P6, and protein F) in a single peptide chain with an …

Earth Orbital Rhythms Links Timing Of Deccan Trap Volcanism Phases And Global Climate Change, Thomas Westerhold, Edoardo Dallanave, Donald Penman, Blair Schoene, Ursula Röhl, Nikolaus Gussone, Junichiro Kuroda

Geosciences Faculty Publications

At the end of the Cretaceous, the massive Deccan trap (DT) volcanic eruptions are regarded as the primary driver of global climate deterioration. Accurate age models are key to unravel the sequence of events related to DT volcanism onset and effects on the global climate system. We establish a direct geochemical link between DT volcanism as recorded in marine osmium isotopic data and global climate change documented in benthic foraminifera carbon and oxygen isotope records. Based on our state-of-the-art astronomically calibrated age model, two major shifts in marine ¹⁸⁷Os/¹⁸⁸Os at 66.49 and 66.28 million years ago are …

Future Applications Of Fluorescence Lifetime Imaging Ophthalmoscopy In Neuro-Ophthalmology, Neurology, And Neurodegenerative Conditions, Daniel M. Markowitz, Elizabeth Affel, György Hajnóczky, Robert C. Sergott

Farber Institute for Neuroscience Faculty Papers

Fluorescence lifetime imaging ophthalmoscopy (FLIO) has emerged as an innovative advancement in retinal imaging, with the potential to provide in vivo non-invasive insights into the mitochondrial metabolism of the retina. Traditional retinal imaging, such as optical coherence tomography (OCT) and fundus autofluorescence (FAF) intensity imaging, focus solely on structural changes to the retina. In contrast, FLIO provides data that may reflect retinal fluorophore activity, some of which may indicate mitochondrial metabolism. This review builds upon the existing literature to describe the principles of FLIO and established uses in retinal diseases while introducing the potential for FLIO in neurodegenerative conditions.

Teacher Persistence: A Narrative Study On The Perceptions Of Career Oklahoma Teachers, Reggy Yount

Student Theses and Dissertations

The topic of this study identified characteristics of successful educators who had persisted as secondary classroom teachers in western Oklahoma. The problem that was studied was the teacher shortage that was impacting students in school districts throughout Oklahoma. The purpose of the study was to find the characteristics of individuals who had persisted in the field of education as classroom teachers. Human Capital Theory was the guiding theoretical framework, which provided a lens that views humans as the critical component in the success of systems. The methodology of this qualitative, narrative study included interviewing secondary classroom teachers in western Oklahoma …

The Interplay Between Endothelial Glycocalyx Maturity And Both The Toxicity And Intracellular Uptake Of Charged Nanoparticles, Claire A. Bridges, Lu D. Fu, Jonathan A. Yeow, Xiaojing D. Huang, Miriam D. Jackson, Rhiannon P. Kuchel, James D. Sterling, Shenda M. Baker, Megan S. Lord

Business and Information Technology Faculty Research & Creative Works

Nanoparticles are widely studied for delivering treatments to target tissues, but few have reached clinical use. Most nanoparticles encounter blood vessels on their way to target tissues. The inner surface of these vessels is lined with endothelial cells covered by a glycocalyx, an extracellular matrix rich in anionic glycans. The role of the glycocalyx in nanoparticle interactions is not well understood. Here, we demonstrate that endothelial cells need extended culture times to synthesize a mature glycocalyx. Our research shows that branched polyethyleneimine functionalized gold nanoparticles bind to endothelial cells expressing either a developing or mature glycocalyx, with the interaction involving …

Biochemical, Structural, And Conformational Characterization Of A Fungal Ethylene-Forming Enzyme, Shramana Chatterjee, Joel A. Rankin, Mark A. Farrugia, Simahudeen Bathir J S Rifayee, Christo Z. Christov, Jian Hu, Et. Al.

Michigan Tech Publications

The ethylene-forming enzyme (EFE) from the fungus Penicillium digitatum strain Pd1 was heterologously produced in Escherichia coli and its properties were compared to the extensively characterized bacterial enzyme from Pseudomonas savastanoi strain PK2. Both enzymes catalyze four reactions: the conversion of 2-oxoglutarate (2OG) to ethylene and CO₂, oxidative decarboxylation of 2OG coupled to _L-arginine (_L-Arg) hydroxylation, uncoupled oxidative decarboxylation of 2OG, and the production of 3-hydroxypropionate (3-HP) from 2OG. The strain Pd1 enzyme exhibited a greater ratio of ethylene production over _L-Arg hydroxylation than the PK2 strain EFE. The uncoupled decarboxylation of 2OG and …

Association Of Inflammatory Biomarkers With New Functional Morbidity At Hospital Discharge In Children Who Survive Severe Sepsis, Mallory Perry-Eaddy, Walter Faig, Martha Curley, Scott Weiss

Department of Pediatrics Faculty Papers

OBJECTIVE: New functional morbidity is common in critically ill children who survive sepsis; yet, the underlying biological mechanisms, particularly the impact of inflammation, remain unknown. We sought to test the hypothesis that increased levels of inflammatory biomarkers during the acute phase of pediatric sepsis are associated with new functional morbidity at hospital discharge.

METHODS: We conducted a post hoc secondary analysis of the MitoPSe clinical study, including N = 119 critically ill children who survived sepsis. Data collected included demographic and clinical variables and 31 inflammatory biomarkers collected at three distinct timepoints (within days 1-2 of PICU admission, days 3-5, …

Noccaea Bulutii (Brassicaceae): A New Species From Northeast Anatolia, Bariş Özüdoğru, Hayri̇ Duman

Turkish Journal of Botany

Noccaea bulutii is described as a new species from Artvin, in NE Anatolia. It resembles N. phyrgia, N. aptera, N. kovatsii and N. ochroleuca, but easily distinguished from all these species by its dentate basal leaves and elongated sterile shoots. Phylogenetic analyses using the nuclear-encoded ribosomal internal transcribed spacer (ITS) region placed N. bulutii and closely related species in a large polytomic clade, but none of these species formed a subclade with N. bulutii, demonstrating that these species are clearly distinct from each other. The species is described with diagnostic characters, detailed photographs, and taxonomic comments provided. The morphological similarities …

Human Mesenchymal Stem Cell Therapy: Potential Advances For Reducing Cystic Fibrosis Infection And Organ Inflammation, Tracey L. Bonfield, Hillard M. Lazarus

Faculty Scholarship

Innovation in cystic fibrosis (CF) supportive care, including implementing new antimicrobial agents, improved physiotherapy, and highly effective modulators therapy, has advanced patient survival into the 4th and 5th decades of life. However, even with these remarkable improvements in therapy, CF patients continue to suffer from pulmonary infection and other visceral organ complications associated with long-term deficient cystic fibrosis transmembrane conductance regulator (CFTR) expression. Human mesenchymal stem cells (MSCs) have been utilized in tissue engineering based upon their capacity to provide structural components of mesenchymal tissues. An alternative role of MSCs, however is their versatile utilization as cell-based infusion powerhouses due …

Pituitary Adenylate Cyclase Activating Polypeptide And Its Receptor As Novel Therapeutic Targets For Opioid Induced Hyperalgesia, Elizaveta Mangutov

Arts & Sciences Graduate Student Theses and Dissertations

Opioids are commonly prescribed for the treatment of pain and headache disorders. However, chronic opioid use can result in a paradoxical increased sensitivity to pain as well as an extension of pain area known as opioid-induced hyperalgesia (OIH). One field OIH has been clearly identified is migraine, known as medication overuse headache (MOH). While opioids may provide acute relief, chronic use results in increased migraine pain severity and progression of migraine from an episodic to chronic state. The primary treatment is opioid cessation, which is difficult to implement as patients are reluctant to stop treatment they believe is helping them, …

High Rate Of Complications With Exchange Nailing For Femoral Nonunions, Benjamin Averkamp, Ziqing Yu, Julia C. Mastracci, Matthew J. Braswell, Andrew T. Chen, Luke A. Lopas, Ishani Sharma, Hassan Farooq, Hassan Mir, Jessica Rivera, Rachel B. Seymour, Joseph R. Hsu, Evidence-Based Musculoskeletal Injury & Trauma Collaborative, Robert D. Zura, Marc Schatz, Et Al

School of Medicine Faculty Publications

Objectives: To evaluate rates of nonunion repair, osseous healing, and outcomes in femoral nonunions with contemporary healing. Design: Retrospective review. Setting: Five academic level 1 trauma centers. Patients/Participants: This study includes adult patients (age older than 18) seen at one of the participating institutions between 2012 and 2019 who sustained a femur fracture (OTA/AO 31, 32, 33) initially treated with intramedullary fixation that developed nonunion and were treated with exchange nailing for the index nonunion surgery. Seventy-nine patients with femoral nonunion met inclusion criteria. Intervention: Exchange nailing for treatment of femoral nonunion. Main Outcome Measurements: The primary outcome measure was …

Clinical And Genetic Markers Of Vascular Toxicity In Glioblastoma Patients: Insights From Nrg Oncology Rtog-0825, Joshua D Strauss, Mark R Gilbert, Minesh Mehta, Ang Li, Renke Zhou, Melissa L Bondy, Erik P Sulman, Ying Yuan, Yanhong Liu, Elizabeth Vera, Merideth M Wendland, Volker W Stieber, Vinay K Puduvalli, Serah Choi, Nina L Martinez, H Ian Robins, Grant K Hunter, Chi-Fan Lin, Vivian A Guedes, Melissa A Richard, Stephanie L Pugh, Terri S Armstrong, Michael E Scheurer

Faculty, Staff and Students Publications

Background: Glioblastoma (GBM) is an aggressive form of brain cancer in which treatment is associated with toxicities that can result in therapy discontinuation or death. This analysis investigated clinical and genetic markers of vascular toxicities in GBM patients during active treatment.

Methods: In total, 591 non-Hispanic White GBM patients with clinical data were included in the analysis from NRG RTOG-0825. Genome-wide association studies (GWAS) were performed from genotyped blood samples (N = 367) by occurrence of thrombosis or hypertension (grade ≥ 2). A clinical prediction model was produced for each vascular toxicity. Significant GWAS variants were then added to the …

Cover And Contents

Turkish Journal of Botany

No abstract provided.

Effects Of Humic Acid And Salt Stress On Growth, Physiological Parameters And Mineral Substance Uptake In Artemisia Dracunculus L. (Tarragon), Serhat Seven, Şener Akinci

Turkish Journal of Botany

In this study, the physiological changes in Artemisia dracunculus L. plants under salinity stress and the remediative roles of leonardite-derived liquid humic acid (HA) were investigated. Salt stress caused a significant decrease in measured growth parameters (plant height, fresh weight of leaves and stems, dry weight of leaves and stems, number of leaves and leaf area). HA had a positive effect on growth parameters at 75 mM NaCl concentration, except for leaf number, but its effect was limited at 150 mM NaCl concentration. The total amount of protein was found to be lower in the leaves of seedlings grown under …