Open Access. Powered by Scholars. Published by Universities.®

Digital Commons Network

Open Access. Powered by Scholars. Published by Universities.®

Discipline
Institution
Keyword
Publication Year
Publication
Publication Type
File Type

Articles 39391 - 39420 of 818039

Full-Text Articles in Entire DC Network

Cultivating Advanced Education For Christian Faculty In Higher Education Institutions: A Phenomenological Study, Gary D. Hyrne Mar 2025

Cultivating Advanced Education For Christian Faculty In Higher Education Institutions: A Phenomenological Study, Gary D. Hyrne

Doctoral Dissertations and Projects

The purpose of this phenomenological study was to understand the experiences of cultivating advanced education for Christian faculty at higher education institutions in the United States. The central research question guiding this study asked: What are the experiences of Christian faculty cultivating advanced education in higher education institutions? The Christian faculty participants' research was guided by data on their lived experiences at private Christian institutions, state universities, or other secular institutions of higher education. Secular relates to the worldly or temporal, not overtly or specifically religious. Bandura’s social cognitive theory guided the study. The research design followed the recommendations of …


Connections Between Co-Occurring Symptoms Of Eating Disorders, Gut Dysbiosis, Anxiety, And Depression, Erin L. Thomas Mar 2025

Connections Between Co-Occurring Symptoms Of Eating Disorders, Gut Dysbiosis, Anxiety, And Depression, Erin L. Thomas

Doctoral Dissertations and Projects

Eating disorders (ED) are a pervasive mental health condition that puts individuals at risk for long-term physical consequences or even death, and current treatment methods typically do not offer long-term efficacy. The current study aims to examine relationships between co-occurring symptoms of EDs, gastrointestinal distress, anxiety, and depression to add to the scientific literature and point towards directions that may increase the benefits of treatment efforts. A total of 72 participants were asked to complete an online survey that consisted of measures from each variable and took about 20 minutes to finish. Participating individuals had to be at least 18 …


A Phenomenological Study Of Women’S Discovery Of Infidelity In Long-Term Relationships, Sinay Butler Mar 2025

A Phenomenological Study Of Women’S Discovery Of Infidelity In Long-Term Relationships, Sinay Butler

Doctoral Dissertations and Projects

The purpose of this phenomenological study was to describe the lived experience of women in long-term marriages in the Spokane, Washington area when they discovered their husbands’ infidelity. All of the women in this study developed symptoms of post-traumatic stress disorder (PTSD) following the discovery of their husbands’ infidelity, however, infidelity is not recognized as a criterion A event for a formal diagnosis. Attachment theory provided the theoretical framework from which to understand the trauma responses of these women better. During the semi-structured interviews, the women described the discovery of infidelity as a traumatic and life-changing event. The research questions …


Bridge Over Troubled Water: Crossing The Bridge Between Biblical Confession And Pastoral Practice Regarding Divorce And Remarriage In Unie-Abc Congregations, Marco H. Kälin Mar 2025

Bridge Over Troubled Water: Crossing The Bridge Between Biblical Confession And Pastoral Practice Regarding Divorce And Remarriage In Unie-Abc Congregations, Marco H. Kälin

Doctoral Dissertations and Projects

Quite a few pastoral workers within the Unie-ABC perceive a discordance between their churches’ biblical-theological confessions regarding divorce and remarriage and the pastoral practice in which they minister. This could induce tension in which a pastoral worker’s counsel is constrained by the church’s biblical position on these issues. In order to diminish that gap, the purpose of this action research project is to implement a redesigned biblical-theological framework regarding divorce and remarriage in training seminars for Unie-ABC pastoral counselors. The project utilized quantitative data collected through email responses and documents provided by Unie-ABC congregations. In addition, qualitative data was developed …


The Impact Of A Social Media Literacy Program On Adolescent Subjective Well-Being, Miranda L. Virone Mar 2025

The Impact Of A Social Media Literacy Program On Adolescent Subjective Well-Being, Miranda L. Virone

Doctoral Dissertations and Projects

This study examined the impact of a Social Media Literacy (SML) program on adolescent subjective well-being. The research was conducted in a public middle school in rural western Pennsylvania, with 102 eighth-grade students participating in a six-week SML intervention as part of regular educational practices. The study utilized pre- and post-intervention assessments to measure changes in both SML and subjective well-being. Data analysis included paired samples t-tests to assess within-group effects and Pearson’s r correlation to evaluate associations between variables. Results indicated no statistically significant effect of the SML program on subjective well-being, leading to the rejection of the first …


A Qualitative Hermeneutic Phenomenological Study With Parents Of A Child With Adhd And Their Lived Experiences With Their Child’S Clinical Mental Health Counselor, Mariah Elizabeth Couser Mar 2025

A Qualitative Hermeneutic Phenomenological Study With Parents Of A Child With Adhd And Their Lived Experiences With Their Child’S Clinical Mental Health Counselor, Mariah Elizabeth Couser

Doctoral Dissertations and Projects

The purpose of this qualitative hermeneutical phenomenological study was to understand the lived experiences of parents with a child who has been diagnosed with Attention Deficit Hyperactive/Impulsive Disorder (ADHD) with their child’s clinical mental health counselor. There are over 6.5 million children diagnosed with ADHD within the United States, and it continues to grow every day. Within the current literature, there is a lack of understanding of what parents of children with ADHD need from their child’s clinical mental health counselor to help reduce their parental stress levels. The theoretical framework guided the hermeneutic phenomenology study, aimed to discover themes …


The Impact Of Religious Music On Psychological Well-Being: A Survey Study Of Chinese Christians In Hong Kong Churches, Ka Man Lee Mar 2025

The Impact Of Religious Music On Psychological Well-Being: A Survey Study Of Chinese Christians In Hong Kong Churches, Ka Man Lee

Doctoral Dissertations and Projects

This cross-sectional survey investigates the relationship between listening to religious music and psychological well-being among Chinese Christians in Hong Kong, addressing a critical gap in Asian studies. Data were collected from 243 participants through a survey comprising demographic questions, music-listening habits (weekly frequency, average duration, and music era preference), and the 24-item Chinese Ryff Psychological Well-being Scale. Multiple linear regression and ANOVA analyses reveal that the average duration of listening to religious music positively associates with overall psychological well-being and its six dimensions, while frequency shows a negative relationship. Traditional religious music (composed in or before 1980) is associated with …


Interpreting The Re-Engagement Of Disenfranchised Youth With Disabilities Through The Lived Experiences Of Alternative High School Staff Members: A Hermeneutic Phenomenological Study, Stephanie Jean Smith Mar 2025

Interpreting The Re-Engagement Of Disenfranchised Youth With Disabilities Through The Lived Experiences Of Alternative High School Staff Members: A Hermeneutic Phenomenological Study, Stephanie Jean Smith

Doctoral Dissertations and Projects

The purpose of this hermeneutic phenomenological study was to interpret the lived experiences of re-engaging at-risk students with disabilities after disenfranchisement from traditional educational settings for non-compulsory alternative charter school staff members at Southwest Charter Academy in the Southwest United States. The theory guiding this study was Bronfenbrenner’s theory on bioecological systems, as it connects the influences of interactions to an individual’s development of behaviors. The central research question for this qualitative study asked: What are the lived experiences of non-compulsory alternative charter school staff members in the Southwest United States who work to re-engage at-risk students with disabilities after …


Lived Experiences Of High School Teachers' Professional Development Post-Covid-19 Pandemic In Rural Georgia: A Transcendental Phenomenology Study, Jesse Regalado Mar 2025

Lived Experiences Of High School Teachers' Professional Development Post-Covid-19 Pandemic In Rural Georgia: A Transcendental Phenomenology Study, Jesse Regalado

Doctoral Dissertations and Projects

The purpose of this phenomenological study is to describe the lived experiences of high school teachers' professional development post-COVID-19 pandemic in rural Georgia, U.S.A. The theories guiding the research are Piaget's theory of disequilibration, addressing how one accommodates and assimilates to adapt to change, and Festinger's (1957) theory of cognitive dissonance, explaining how one adapts, assimilates, and accommodates to avoid disharmony. The study's central question is, what are high school teachers' perceptions on the practical or academic professional development they received post-COVID-19 pandemic in rural Georgia, United States, used to promote leadership, teaching mastery, or pedagogical practices? This study utilized …


Improving Management Of Suicidality Within An Outpatient Eating Disorder Treatment Program Through Standardization Of A Suicide Rating Scale Among Clinical Staff Members: An Evidenced-Based Practice Project, Nicole Neale Mar 2025

Improving Management Of Suicidality Within An Outpatient Eating Disorder Treatment Program Through Standardization Of A Suicide Rating Scale Among Clinical Staff Members: An Evidenced-Based Practice Project, Nicole Neale

Doctoral Dissertations and Projects

Standardization of suicide assessment protocols is essential for maintaining standards of care and optimizing patient safety. However, many healthcare organizations lack a universal protocol for suicide assessment, likely due to the absence of a gold-standard method or tool. This evidence- based practice project aims to enhance the accuracy and consistency of suicide assessments for individuals diagnosed with eating disorders as well as other mental health disorders, ultimately improving patient safety measures and outcomes within an eating disorder treatment center. This project includes a thorough literature review of suicide risk factors, assessment methods, and available tools, followed by the education and …


Lived Experiences Of Initial Romantic Attraction In Codependent And Non-Codependent Women: A Qualitative Study, Karen Jaworski Mar 2025

Lived Experiences Of Initial Romantic Attraction In Codependent And Non-Codependent Women: A Qualitative Study, Karen Jaworski

Doctoral Dissertations and Projects

Codependency is seen to have a negative impact on individuals right from the first meeting with a prospective partner through the painful ending of the relationship. Despite the inner turmoil it causes, affected individuals continue to repeatedly gravitate toward dysfunctional partners. This study explored the phenomena of codependency and initial romantic attraction to see if there were any differences in the descriptions of lived experience between the codependent and non-codependent participants. During this qualitative study, ten codependent and ten non-codependent women underwent in-depth semi-structured, one-on-one interviews to gain deeper insights on their perception of attraction, initial attraction to past relational …


Delivering Guideline-Directed Medical Therapy For Heart Failure With Reduced Ejection Fraction As An Over-Encapsulated Polypill: Rationale And Protocol For The Combo-Hf-X Pilot Crossover Randomised Clinical Trial, Colette Dejong, Mark D Huffman, Anubha Agarwal, Et Al. Mar 2025

Delivering Guideline-Directed Medical Therapy For Heart Failure With Reduced Ejection Fraction As An Over-Encapsulated Polypill: Rationale And Protocol For The Combo-Hf-X Pilot Crossover Randomised Clinical Trial, Colette Dejong, Mark D Huffman, Anubha Agarwal, Et Al.

2020-Current year OA Pubs

INTRODUCTION: A four-drug regimen of guideline-directed medical therapy (GDMT) for heart failure with reduced ejection fraction (HFrEF) is underused, in part due to prescriber inertia and low patient adherence. Although fixed-dose combination pills ('polypills') have improved adherence and clinical outcomes for other conditions, there are no polypills available that combine multiple classes of GDMT for HFrEF. Pharmacy-level over-encapsulation, in which several tablets are combined into one capsule, offers an opportunity to create customised HFrEF polypills with the goal of improving delivery of HFrEF therapies.

METHODS AND ANALYSIS: In the COMBO-HF-X pilot crossover randomised clinical trial, we will enrol 30-40 patients …


Ppdpf: Preventing Kidney Disease Through Nad+, Shin-Ichiro Imai Mar 2025

Ppdpf: Preventing Kidney Disease Through Nad+, Shin-Ichiro Imai

2020-Current year OA Pubs

Researchers have discovered PPDPF, a critical cellular factor that controls NAD


Shuffle, Dereck Daschke Mar 2025

Shuffle, Dereck Daschke

Journal of Religion & Film

This is a film review of Shuffle (2025), directed by Benjamin Flaherty.


Molecular Mechanisms And Role Of Camel Milk Derived Bioactive Peptides Towards Insulin And Glp-1 Receptor Activation, Irfa Anwar Mar 2025

Molecular Mechanisms And Role Of Camel Milk Derived Bioactive Peptides Towards Insulin And Glp-1 Receptor Activation, Irfa Anwar

Thesis/ Dissertation Defenses

Camel milk (CM), renowned for its exceptional nutritional and medicinal properties, has been a crucial resource in arid regions for centuries. Its notable antidiabetic effects, supported by extensive research through in vitro, in vivo, and clinical studies, have gained significant scientific attention. However, the underlying cellular and molecular mechanisms remain largely unclear. Our previous research demonstrated that camel milk whey hydrolysates (CWHs) induce insulin receptor (IR) activation and downstream signaling, promoting glucose uptake in vitro using HEK293 and HepG2 cells. Building on this foundation, the current study focused on synthesizing nine of the most potent peptides (designated P1-9) derived from …


News From The Chapters 1984-85, Robert M. Ward Mar 2025

News From The Chapters 1984-85, Robert M. Ward

The Geographical Bulletin

News from the Chapters 1984-85


The South Dakota State Geography Convention: A Unique Educational Opportunity And Event, Edward Patrick Hogan Mar 2025

The South Dakota State Geography Convention: A Unique Educational Opportunity And Event, Edward Patrick Hogan

The Geographical Bulletin

The South Dakota State Geography (SDSU) Convention, held annually at South Dakota State University in Brookings, is indeed a unique educational opportunity and event. The faculty of the Department of Geography at SDSU believe that the convention makes major contributions to the discipline, the state of South Dakota and community of Brookings, the university, and particularly to the Department of Geography and its students. This student planned and conducted convention affords students an outstanding educational opportunity. The convention has evolved over a period of fifteen years and continues to grow and change as the program adapts to new opportunities and …


Stability Enhancement Of Doxepin Hydrochloride Capsules, Usp 10 Mg, 25 Mg, 50 Mg, 75 Mg And 100 Mg, Anonymous Mar 2025

Stability Enhancement Of Doxepin Hydrochloride Capsules, Usp 10 Mg, 25 Mg, 50 Mg, 75 Mg And 100 Mg, Anonymous

Defensive Publications Series

Doxepin is used to treat anxiety or depression. It is also used to treat insomnia (trouble with sleeping). On 8/4/2023, FDA issued a final guidance on Recommended Acceptable Intake Limits for Nitrosamine Drug Substance-Related Impurities (NDSRIs) (August 2023) (RAIL Guidance) which provided recommendations for NDSRI AI limits based on predicted carcinogenic potency categorization. On 9/4/2024, FDA issued a final guidance on Control of Nitrosamine Impurities in Human Drugs (September 2024, Rev.2) (Nitrosamine Guidance). The Nitrosamine Guidance describes two classes of nitrosamines – small-molecule nitrosamines and NDSRIs; and also provides recommendations to industry on mitigation strategies to control nitrosamines and on …


Women Beyond The Veil: Authority And Societal Norms In Spiritualism, Anastasia Gwendolyn Smith Mar 2025

Women Beyond The Veil: Authority And Societal Norms In Spiritualism, Anastasia Gwendolyn Smith

Honors Capstone Projects and Theses

No abstract provided.


Longitudinal Changes In Aerodigestive Responses To Varying Nipple Properties In Infant Pigs, François D H Gould, Christopher Mayerl, Khaled Adjerid, Jessica Reibel, Nichole Charles, Chloe Edmonds, Rebecca Z German Mar 2025

Longitudinal Changes In Aerodigestive Responses To Varying Nipple Properties In Infant Pigs, François D H Gould, Christopher Mayerl, Khaled Adjerid, Jessica Reibel, Nichole Charles, Chloe Edmonds, Rebecca Z German

Rowan-Virtua School of Osteopathic Medicine Departmental Research

Coordination of respiration and swallowing is critical for survival in infant mammals and changes throughout infant maturation. Infants show sensorimotor feeding responses to changes in physical properties of nipples. Commercial nipples are promoted as improving aerodigestive coordination. However, it is unknown how nipple properties influence coordination of respiration and swallowing. Furthermore, how infant-nipple interactions change throughout maturation is not well understood. We designed and manufactured four silicone nipples of the same shape that varied in two parameters: nipple opening diameter and nipple stiffness. We used our validated infant pig model to test the impact of nipple parameters on aerodigestive coordination …


Grounded In Touch: The Science Behind Anxiety Relief And Human Connection, Misty Rhoads Ph.D. Czb, Mary Murphy M.A., Lmt, Czb, Mary L. Behrens Pt, Czb, Rhonda Salvo Pt, Czb, Sarah-Elizabeth Anderson Lmt, Czb, Clare Gowen Pt, Czb, Dawn Humbles Lsh, Czb, Veronica Quarry Pt, Czb, Deborah Rosene Ph.D., Czb, Wendy Tribelhorn Lmt, Czb, Jared Urcheck L.Ac, Czb, Deanna Waggy Otr, Czb Mar 2025

Grounded In Touch: The Science Behind Anxiety Relief And Human Connection, Misty Rhoads Ph.D. Czb, Mary Murphy M.A., Lmt, Czb, Mary L. Behrens Pt, Czb, Rhonda Salvo Pt, Czb, Sarah-Elizabeth Anderson Lmt, Czb, Clare Gowen Pt, Czb, Dawn Humbles Lsh, Czb, Veronica Quarry Pt, Czb, Deborah Rosene Ph.D., Czb, Wendy Tribelhorn Lmt, Czb, Jared Urcheck L.Ac, Czb, Deanna Waggy Otr, Czb

Journal of Transformative Touch

Background: Anxiety disorders are among the most pervasive mental health challenges worldwide, affecting individuals across all demographics and socioeconomic backgrounds. As a leading contributor to disability and diminished quality of life, anxiety continues to rise in prevalence, exacerbated by global crises and societal stressors. This study explored how Zero Balancing (ZB) supports individuals with anxiety. Researchers hypothesized that ZB would lower the perceived severity of general anxiety and reduce perceived anxiety symptoms.

Methods: A concurrent mixed-methods phenomenological research design was utilized to honor the holistic nature of bodywork and explore participants' lived experiences. This national study involved 320 ZB sessions …


Michigan Academician, Volume 49, Issue 2 Mar 2025

Michigan Academician, Volume 49, Issue 2

Michigan Academician

Michigan Academician Volume 49, Issue 2.


Bryce Canyon Aspen: Recent Trends, Future Actions, Paul C. Rogers Mar 2025

Bryce Canyon Aspen: Recent Trends, Future Actions, Paul C. Rogers

Aspen Bibliography

In cooperation with Bryce Canyon National Park, we undertook a survey of quaking aspen (Populus tremuloides Michx.) conditions throughout the Park with the intention of better understanding conditions and prescribing corrective measures where needed. There are clear disparities within the Park between sustainable aspen conditions and failing stands. Based on condition of mature trees, but most importantly regeneration and recruitment of juvenile stems, most aspen forests within Bryce Canyon are in poor condition. Aspen recruitment—generally sapling-sized trees that have survived browsing ungulates—is the most important metric of future stand resilience and here we found 83% of all aspen sample …


Herbivory In A Low Arctic Wetland Alters Intraspecific Plant Root Traits With Consequences For Carbon And Nitrogen Cycling, Emily A. Chavez, Jaron Adkins, Bonnie G. Waring, Karen H. Beard, Ryan T. Choi, Lindsay Miller, Taylor Saunders, Trisha B. Atwood Mar 2025

Herbivory In A Low Arctic Wetland Alters Intraspecific Plant Root Traits With Consequences For Carbon And Nitrogen Cycling, Emily A. Chavez, Jaron Adkins, Bonnie G. Waring, Karen H. Beard, Ryan T. Choi, Lindsay Miller, Taylor Saunders, Trisha B. Atwood

Wildland Resources Faculty Publications

  1. High latitude wetlands are ecologically important ecosystems due to their large carbon (C) storage capacity and because they serve as breeding and nesting habitat for large populations of migratory birds. Goose herbivory in wetland meadows affects leaf chemical and morphological traits and also influences soil properties by increasing soil temperature and depositing faeces. Grazing-induced changes to above-ground traits and soil properties impact C cycling, but the influence of grazing on root-mediated C and nitrogen (N) cycling has not been explored.

  2. We investigated how goose herbivory in a low-Arctic coastal wetland in western Alaska affected root morphological, physiological and chemical traits …


Inhibition Of The Metalloprotease Adam19 As A Novel Senomorphic Strategy To Ameliorate Gut Permeability And Senescence Markers By Modulating Senescence-Associated Secretory Phenotype (Sasp)., Sudipta Bar, Tyler A U Hilsabeck, B Pattavina, José Alberto López-Domínguez, Nathan Basisty, Joanna Bons, Mark Watson, Birgit Schilling, Judith Campisi, Pankaj Kapahi, Amit Sharma Mar 2025

Inhibition Of The Metalloprotease Adam19 As A Novel Senomorphic Strategy To Ameliorate Gut Permeability And Senescence Markers By Modulating Senescence-Associated Secretory Phenotype (Sasp)., Sudipta Bar, Tyler A U Hilsabeck, B Pattavina, José Alberto López-Domínguez, Nathan Basisty, Joanna Bons, Mark Watson, Birgit Schilling, Judith Campisi, Pankaj Kapahi, Amit Sharma

Faculty Research 2025

Accumulation of DNA damage can accelerate aging through cellular senescence. Previously, we established a Drosophila model to investigate the effects of radiation-induced DNA damage on the intestine. In this model, we examined irradiation-responsive senescence in the fly intestine. Through an unbiased genome-wide association study (GWAS) utilizing 156 strains from the Drosophila Genetic Reference Panel (DGRP), we identified meltrin (the drosophila orthologue of mammalian ADAM19) as a potential modulator of the senescence-associated secretory phenotype (SASP). Knockdown of meltrin resulted in reduced gut permeability, DNA damage, and expression of the senescence marker β-galactosidase (SA-β-gal) in the fly gut following irradiation. Additionally, inhibition …


Resistance Signatures To Oncolytic Vesiculoviruses In Pancreatic Ductal Adenocarcinoma, Chelsae R. Watters, Oumar Barro, Musa Gabere, Mia Y. Masuda, Natalie M. Elliott, Elizabeth A. Raupach, Khandoker Usran Ferdous, Mulu Z. Tesfay, Omeed Moaven, Yumei Zhou, Michael T. Barrett, Kenneth H. Buetow, Bolni Marius Nagalo, Mitesh J. Borad Mar 2025

Resistance Signatures To Oncolytic Vesiculoviruses In Pancreatic Ductal Adenocarcinoma, Chelsae R. Watters, Oumar Barro, Musa Gabere, Mia Y. Masuda, Natalie M. Elliott, Elizabeth A. Raupach, Khandoker Usran Ferdous, Mulu Z. Tesfay, Omeed Moaven, Yumei Zhou, Michael T. Barrett, Kenneth H. Buetow, Bolni Marius Nagalo, Mitesh J. Borad

School of Medicine Faculty Publications

Pancreatic ductal adenocarcinoma (PDAC) shows limited response to conventional therapies and immunotherapy due to dense stromal barriers and poor immunogenicity. Oncolytic vesiculoviruses hold therapeutic potential for PDAC by lysis of PDAC cells to release tumor-associated antigens, increasing tumor immunogenicity. We previously reported the efficacy of a chimeric vesicular stomatitis virus (VSV) expressing Morreton virus (MorV) glycoprotein in sarcoma. Here, we evaluated the oncolytic potency of MorV and chimeric virus, VMG, in PDAC models. VMG exhibited heterogeneous oncolysis across human PDAC cell lines and PDX cells, similar to parental viruses VSV and MorV. To evaluate potential signatures correlated with resistance to …


Michigan Academician, Volume 49, Issue 3 Mar 2025

Michigan Academician, Volume 49, Issue 3

Michigan Academician

Michigan Academician Volume 49, Issue 3


Anti-Maa Antibodies Increase Disease Severity In A Mouse Model Of Inflammatory Bowel Disease, William P. Mcguire Iii, Michael J. Duryee, Rizwan Ahmad, Punita Dhawan, Amar B. Singh, Geoffrey M. Thiele Mar 2025

Anti-Maa Antibodies Increase Disease Severity In A Mouse Model Of Inflammatory Bowel Disease, William P. Mcguire Iii, Michael J. Duryee, Rizwan Ahmad, Punita Dhawan, Amar B. Singh, Geoffrey M. Thiele

EMET Projects

No abstract provided.


From Genes To Patterns: A Framework For Modeling The Emergence Of Embryonic Development From Transcriptional Regulation, Jimena Garcia-Guillen, Ezzat El-Sherif Mar 2025

From Genes To Patterns: A Framework For Modeling The Emergence Of Embryonic Development From Transcriptional Regulation, Jimena Garcia-Guillen, Ezzat El-Sherif

School of Integrative Biological & Chemical Sciences Faculty Publications

Understanding embryonic patterning, the process by which groups of cells are partitioned into distinct identities defined by gene expression, is a central challenge in developmental biology. This complex phenomenon is driven by precise spatial and temporal regulation of gene expression across many cells, resulting in the emergence of highly organized tissue structures. While similar emergent behavior is well understood in other fields, such as statistical mechanics, the regulation of gene expression in development remains less clear, particularly regarding how molecular-level gene interactions lead to the large-scale patterns observed in embryos. In this study, we present a modeling framework that bridges …


Using The 5ms Framework To Advance Aging-Responsive Care For Heart Failure With Reduced Ejection Fraction, Abigail Latimer, Debra K. Moser, Jia-Rong Wu, Kim K. Birtcher, Malachy J. Clancy, Jennifer D. Portz, Joanna Paladino, Daniel D. Matlock, Christopher E. Knoepke Mar 2025

Using The 5ms Framework To Advance Aging-Responsive Care For Heart Failure With Reduced Ejection Fraction, Abigail Latimer, Debra K. Moser, Jia-Rong Wu, Kim K. Birtcher, Malachy J. Clancy, Jennifer D. Portz, Joanna Paladino, Daniel D. Matlock, Christopher E. Knoepke

Department of Occupational Therapy Faculty Papers

Complexity of care is the inevitable consequence of an aging population and is particularly true in instances where patients are managing chronic conditions such as heart failure with reduced ejection fraction (HFrEF). HFrEF itself is complex, with an undulating course of illness, increased risk of sudden cardiac death, and myriad accompanying treatment considerations. Generalist management of HFrEF among older patients is further complicated by competing comorbidities, potential for financial toxicity, potential for mental health symptoms, and risk of care with does not align with goals and preferences. The 5Ms (multicomplexity, mind, mobility, medications, and matters most) is a holistic conceptualization …