Digital Commons Network^™

The Mediation Effect Of White Racial Affect On Color-Blind Racial Attitudes And Multicultural Counseling Competence, Noah Schieffer Scanlon

Electronic Theses and Dissertations

Racial bias is something that can impact many fields, including the field of psychology. There is growing research in examining the relationship between multicultural counseling competence and color-blind racial attitudes as well as other factors like White racial affect Few studies have examined the potential mediating relationship White racial affect may have on color-blind racial attitudes and multicultural counseling competence. To address this gap, this study provides insight into how White racial affect mediates the relationship between color-blind racial attitudes and multicultural counseling competence among white psychology trainees. This study also further examined the extent to which color-blind racial attitudes …

Quantifying The Impact Of Workshops Promoting Microbiome Data Standards And Data Stewardship, Julia M. Kelliher, Francisca E. Rodriguez, Leah Y. Johnson, Simon Roux, Montana Smith, Ishi Keenum, Et. Al.

Michigan Tech Publications

The field of microbiome research continues to grow at a rapid pace, with multi-omics approaches becoming widely used to interrogate diverse microbiome samples. However, due to lagging awareness and implementation of standards and data stewardship, many datasets are produced that are not comparable, reproducible, or reusable. In 2021, the National Microbiome Data Collaborative launched its Ambassador Program, which utilizes a community-learning model to annually train a cohort of early-career researchers in microbiome data stewardship best practices. These Ambassadors then host workshops and other events to communicate these themes to their respective microbiome research communities. To quantify the impact of this …

Radial Glia Integrin Avb8 Regulates Cell Autonomous Microglial Tgfβ1 Signaling That Is Necessary For Microglial Identity, Gabriel Mckinsey, Nicolas Santander, Xiaoming Zhang, Kilian Kleemann, Lauren Tran, Aditya Katewa, Kaylynn Conant, Matthew Barraza, Kian Waddell, Carlos Lizama, Marie La Russa, Ji Hyun Koo, Hyunji Lee, Dibyanti Mukherjee, Helena Paidassi, E. S. Anton, Kamran Atabai, Dean Sheppard, Oleg Butovsky, Thomas Arnold

Department of Medicine Faculty Papers

Microglial diversity arises from the interplay between inherent genetic programs and external environmental signals. However, the mechanisms by which these processes develop and interact within the growing brain are not yet fully understood. Here, we show that radial glia-expressed integrin beta 8 (ITGB8) activates microglia-expressed TGFβ1 to drive microglial development. Domain-restricted deletion of Itgb8 in these progenitors results in regionally restricted and developmentally arrested microglia that persist into adulthood. In the absence of autocrine TGFβ1 signaling, microglia adopt a similar phenotype, leading to neuromotor symptoms almost identical to Itgb8 mutant mice. In contrast, microglia lacking the canonical TGFβ signal transducers …

Lower Cytoplasmic Expression Of Ddit4 Is Associated With Poor Prognosis In Gastric Cancer Patients, Masoumeh Dehghan Manshadi, Fatemeh Tajik, Leili Saeednejad Zanjani, Farideh Hashemi, Mandana Rahimi, Fahimeh Fattahi, Sadegh Safaei, Zahra Madjd, Roya Ghods

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

INTRODUCTION: DNA damage-inducible transcript 4 (DDIT4), also known as Redd1, Dig2, and RTP801 was identified to be upregulated in response to a variety of cellular stresses, including DNA damage, endoplasmic reticulum stress, and energy stress. Several studies have discovered that dysregulation of DDIT4 involved in various cancers with paradoxical expression and roles. Hence, this study was designed to investigate the clinical significance and prognostic value of DDIT4 in different subtypes of gastric cancer (GC).

MATERIALS AND METHODS: To evaluate the expression pattern of DDIT4 in GC tissues as well as adjacent normal tissue, we utilized immunohistochemistry on tissue microarray (TMA) …

Synthetic Protein Mimetic Based Therapies For Neurodegeneration, Nicholas H. Stillman

Electronic Theses and Dissertations

Protein-protein interactions (PPIs) are crucial for the regulation of a majority of, if not every fundamental cellular process. Despite their role in regular biological processes, dysregulated and/or aberrant protein-protein interactions (aPPIs) are often related to the onset of disease including cancer, viral infection, and amyloid diseases. aPPIs have historically been deemed ‘undruggable’ due to their large surface area and lack of a binding cavity; however, today, more than 40 disease-related aPPIs have been targeted with small molecules and several of those have reached clinical trials.

A class of synthetic protein mimetics called oligopyridylamides (OPs) has been shown to inhibit disease-related …

Advancing Tka Biomechanics: From Joint Simulator To Boundary Condition Development, Yashar Ali Behnam

Electronic Theses and Dissertations

This dissertation addresses four specific aims that collectively attempted to advance the experimental and computational analysis of total knee arthroplasty (TKA) components. The first study focused on the development of a novel whole knee joint simulator capable of simultaneous tibiofemoral and patellofemoral knee loading. This simulator employs custom fixturing to facilitate dynamic, unconstrained, muscle-driven PF articulation alongside controlled TF contact mechanics. Validation against experimental measurements showed strong agreement, demonstrating the simulator's potential as a valuable tool for future TKA design and surgical technique investigations.

The second study verified implant-specific physiological boundary conditions which accurately simulate activities of daily living using …

Determinants Of Knee Motion In Health, Disease, And Repair, Sean Edward Higinbotham

Electronic Theses and Dissertations

The human knee joint is a complex and intricate structure, enabling a wide range of motions and facilitating various dynamic activities throughout a person's lifetime. The combination of the knee's complexity and its role as a primary load-bearing joint has made it susceptible to regular wear and tear, leading to pain and the development of Osteoarthritis (OA), to which, the only treatment currently is total knee arthroplasty (TKA). Despite TKA being a mature procedure, 20% of patients receiving a TKA are dissatisfied with their “new” knee. To reduce that 20% dissatisfaction and improve surgical outcomes, orthopedic companies are developing advanced …

The Efficacy Of Psychological Interventions On Treating Post-Concussion Syndrome: An Integrative Review, Esther Smith

Senior Honors Theses

Post-concussion syndrome, which occurs when concussion symptoms last longer than 3 months, is an area not well researched and often misunderstood. Post-concussion syndrome lingers without research based, effective treatment options for full patient recovery. This review was conducted to find the efficacy of psychological treatment options for patients with post-concussion syndrome. Eight databases, libraries, a registry, and some grey literature were searched within the past five years. The search process was documented with the PRISMA flow diagram. Through the inclusion criteria, eleven articles were selected as the primary sources. These studies found that the psychological interventions tested showed small improvements …

The Impact Of Covid-19 On The United States Higher Education System, Phoenix Daniel Van Wormer

University Honors Theses

In the spring of 2020, colleges across the United States rapidly transitioned to online/remote learning during the COVID-19 global pandemic. Since then, online and remote learning have evolved into an integral component of higher education. This thesis examines the extent to which COVID-19-mandated remote and online learning impacted students pursuing higher education in the United States. By utilizing research that compares academic structures before and after the pandemic, I demonstrate how the shift to online and remote learning has changed teaching and learning methods. I also evaluate the impact of these changes on student performance and engagement, with particular focus …

Prediction Of Persistent Incomplete Occlusion Of Intracranial Aneurysms Treated With Woven Endobridge Device, Muhammed Amir Essibayi, Mohamed Sobhi Jabal, Hasan Jamil, Hamza Adel Salim, Basel Musmar, Nimer Adeeb, Mahmoud Dibas, Nicole M. Cancelliere, Jose Danilo Bengzon, Oktay Algin, Sherief Ghozy, Sovann V. Lay, Adrien Guenego, Leonardo Renieri, Joseph Carnevale, Guillaume Saliou, Panagiotis Mastorakos, Kareem El Naamani, Eimad Shotar, Markus Möhlenbruch, Michael Kral, Charlotte Chung, Mohamed M. Salem, Ivan Lylyk, Paul M. Foreman, Hamza Shaikh, Vedran Župančić, Muhammad U. Hafeez, Joshua Catapano, Muhammad Waqas, Muhammed Said Besler, Yasin Celal Gunes, James D. Rabinov, Julian Maingard, Clemens M. Schirmer, Mariangela Piano, Anna L. Kühn, Caterina Michelozzi, Robert M. Starke, Ameer Hassan, Mark Ogilvie, Anh Nguyen, Jesse Jones, Waleed Brinjikji, Marie T. Nawka, Marios Psychogios, Christian Ulfert, Bryan Pukenas, Jan-Karl Burkhardt, Thien Huynh, Juan Carlos Martinez-Gutierrez, Sunil A. Sheth, Diana Slawski, Rabih Tawk, Benjamin Pulli, Boris Lubicz, Pietro Panni, Ajit S. Puri, Guglielmo Pero, Eytan Raz, Christoph J. Griessenauer, Hamed Asadi, Adnan Siddiqui, Elad I. Levy, Deepak Khatri, Neil Haranhalli, Andrew F. Ducruet, Felipe C. Albuquerque, Robert W. Regenhardt, Christopher J. Stapleton, Peter Kan, Vladimir Kalousek, Pedro Lylyk, Srikanth Boddu, Jared Knopman, Stavropoula I. Tjoumakaris, Hugo H. Cuellar-Saenz, Pascal Jabbour, Frédéric Clarençon, Nicola Limbucci, Vitor Mendes Pereira, Aman B. Patel, David J. Altschul, Adam A. Dmytriw, Worldwideweb Consortium Collaborators

Department of Neurosurgery Faculty Papers

While the Woven EndoBridge (WEB) device has transformed the treatment of wide-neck intracranial aneurysms, incomplete occlusion remains a significant challenge requiring better understanding of contributing factors. A retrospective analysis was conducted on multicenter data from patients who underwent WEB device treatment for intracranial aneurysms between January 2011 and December 2022. Using machine learning models, Cox regression, and time-stratified analyses, we evaluated factors associated with persistent incomplete occlusion, defined as non-improving Raymond-Roy Occlusion Classification grade 2 or 3 at final follow-up. Among 813 patients (607 with < 24 months follow-up, 206 with ≥ 24 months), machine learning analysis identified aneurysm height, Acom location, neck diameter, and pretreatment mRS as predictors of persistent incomplete occlusion. On Cox regression. larger aneurysm neck diameter (HR 1.13, 95% CI 1.01-1.27, p = 0.027) and height (HR 1.14, 95% CI 1.02-1.26, p = 0.017), and radial …

Session Ia: Biology Presentation 3 - Beyond Weight Loss: The Effects Of The Glp-1 Agonist, Semaglutide, On Weight Care, Type Ii Diabetes Management, And Cardiac Function In Obese Patients, Amber Smith

Life of the Scholar Multidisciplinary Conference

Determining whether the drug Semaglutide, also known as Ozempic or Wegovy, is not only an effective treatment for weight loss, but also for management of type II diabetes and obesity-related heart failure, such as adverse cardiac remodeling and left atrial volume increase.

Session Ia: Biology Presentation 4 - Parkinson's Disease: Understanding Risk Factors, Causes, And Potential Treatments, Emma Hewitt

Life of the Scholar Multidisciplinary Conference

No abstract provided.

Beyond The Institution Of Motherhood: Shifting The Paradigm, Gabrielle Wilson

Graduate Research Conference (GSIS)

This paper explores declining birth rates as a global act of resistance and reclamation by women and birthing individuals against hyper-masculinized institutions, using South Korea's 4B movement as a case study. The 4B movement, which rejects marriage, childbirth, romance, and heterosexual relationships, represents a paradigm shift challenging entrenched gender norms, state control, and systemic inequities. It exemplifies a global phenomenon as similar movements gain traction in the U.S., Japan, and beyond, amidst rising conservatism and declining fertility rates. Framing this analysis with intersectionality, Feminist IR theory, and Kuhn’s paradigm shift model, the paper argues that this resistance signifies a transformative …

Modeling The Impact Of Nato Policy Actions On Taliban Disinformation Campaigns With Lotka-Volterra Models, Timothy Tarter, Bella Santos

Graduate Research Conference (GSIS)

In this paper, we use an adaptation of the Lotka-Volterra Predator-Prey framework (via Affilit Et. Al.) to model the relationship between Taliban disinformation campaigns and NATO’s attempts to counter them. We find that aggression is a significantly preferred strategy over stagnation; this result should prompt decisionmakers to take strong stances against disinformation campaigns while maintaining a healthy defense against retribution. This leads us to propose the NATO Afghan Youth for Change program, which provides scholarships to individuals throughout the Afghan diaspora to become NATO influencers - a role which will both advance their personal goals and mitigate the spread of …

The Shorthorn: September 25, 1923

The Shorthorn Newspaper Collection: 1920s

No abstract provided.

U.S. - Azerbaijan Cooperation In The Field Of Security, Malahat Eynalizade

Graduate Research Conference (GSIS)

This research work will explore the security partnership between the United States and Azerbaijan. A key issue in the Western relationship with Azerbaijan is security. The defense and security cooperation between the United States and Azerbaijan is a fundamental aspect of their bilateral relations. It serves as a driving force behind their political ties and provides a solid foundation for enhancing the capabilities of Azerbaijan’s institutions through various aid programs. In the late 1990s, the U.S. government concluded that it had significant, albeit ancillary, interests in the Caucasus and Central Asia. Security in the South Caucasus is important to the …

Embedding And Enabling Multi-Domain Combat Capabilities With Partners And Allies: A Joint Concept Proposal, Nathan Colvin, Aljoša Kaučevič, Randall Mercer

Graduate Research Conference (GSIS)

Future military operations will rely upon a coalition partnership’s ability to conduct regional and global operations across all domains. Currently the US has the most robust multi-domain skill sets of any existing military force, but the US cannot be solely responsible for operations around the globe. To do so would be geopolitically and economically infeasible. An answer may be to build cohesive coalition force units capable of combining localized capabilities and specialized US global competencies. The ability to respond to any type of threat through the synergy of coalition strengths will act to deter regional threats throughout the cooperation, competition, …

The Shorthorn: April 17, 1923

The Shorthorn Newspaper Collection: 1920s

No abstract provided.

The Shorthorn: April 03, 1923

The Shorthorn Newspaper Collection: 1920s

No abstract provided.

The Shorthorn: February 20, 1923

The Shorthorn Newspaper Collection: 1920s

No abstract provided.

The Shorthorn: January 16, 1923

The Shorthorn Newspaper Collection: 1920s

No abstract provided.

The Shorthorn: October 31, 1922

The Shorthorn Newspaper Collection: 1920s

No abstract provided.

The Shorthorn: October 24, 1922

The Shorthorn Newspaper Collection: 1920s

No abstract provided.

Cardiometabolic Risk Factors Associated With Physical Fitness And Activity Levels: An Exploratory Study Of Us College Students, Keegan T. Peterson, Gabrielle Barraco, Jennifer Niessner, Melissa Rodgers, Melissa Bopp

International Journal of Exercise Science

International Journal of Exercise Science 18(8): 379-393, 2025. College students are a vulnerable population at risk of developing and/or experiencing poor physical fitness and insufficient physical activity (PA) levels, both associated with poor cardiometabolic health. Thus, this study assessed the association of physical fitness and domain-specific PA levels on cardiometabolic risk factors (CMRFs) among college students. A volunteer sample of students enrolled in general health and wellness courses at a large, Northeastern U.S. institution from Spring 2023 – Spring 2024 (n=1418, 69.0% male, 89.9% non-Hispanic White) completed an objective health assessment as part of a required course assignment. CMRFs (e.g., …

Regeneration In Planarians Modifies Behavioral Switching, N. S. Tellakula, Eva-Maria S. Collins, W. B. Kristan Jr.

Biology Faculty Works

The planarian Dugesia japonica responds differently to localized stimuli: anterior regions turn, middle regions elongate, and posterior regions contract. If cut into several pieces, each piece immediately produces the same three responses. Over several days, each piece regenerates all transected body parts. This study tested how the pieces coordinate behavioral responses during regeneration. We first determined the locations of the turning/elongation and elongation/contraction behavioral switches. Immediately, all transections moved both switching sites away from the cut sites so that the worm pieces produced the same three responses as intact worms. During regeneration, the sites of behavioral switching moved progressively closer …

Insect Wing Flexibility Improves The Aerodynamic Performance Of Small Revolving Wings, Gal Ribak, Ori Stearns, Kiruthika Sundararajan, Duvall Dickerson-Evans, Dana Melamed, Maya Rabinovich, Roi Gurka

Physics and Engineering Science

Insect wings are flexible, elastically deforming under loads experienced during flapping. The adaptive value of this flexibility was tested using a revolving wing set-up. We show that the wing flexibility of the beetle Batocera rufomaculata, suppresses the reduction in lift coefficient that is expected to occur with a reduction of wing size compared to rigid propeller blades. Moreover, the scaling of wing flexibility with size is intra-specifically tuned through changes in wing-vein cross-section, resulting in smaller wings achieving proportionally larger chordwise deformations compared to larger wings, when loaded with aerodynamic forces. These elastic deformations control the separation of flow from …

Medical School Watercooler Newsletter - March 21, 2025, Lindsay Hughes

Watercooler Newsletter

This is the Friday, March 21, 2025 edition of the Frederick P. Whiddon College of Medicine's newsletter -- Watercooler.

Contents include:

• Match Day 2025: Senior medical students match in residency programs -- and love
• Integrative Health and Wellness Program gaining state and national recognition
• 14th Gulf Coast Trauma Symposium set for March 26-28
• Children's & Women's Hospital receives grant for neonatal abstinence syndrome
• Cancer researcher awarded $300,000 NSF grant to study mitochondria

The Importance Of Recruitment Of Low-Income Pregnant Persons In Interdisciplinary Research To Understand The Impact Of Social And Environmental Determinants: Lessons Learned About Implementation And Recruitment, Erika R. Marquez, Amanda Haboush-Deloye, Elizabeth M. Lawrence, Selam Ayele, Courtney Coughenour, Nora Doyle, Wynona Dizon, Lizbeth Perez Rodriguez, Chloe Bombara

Environmental & Global Health Faculty Research

Background: Prior research indicates that enrolling underrepresented populations in clinical research is challenging. Although research has identified some barriers to participation and strategies to overcome them, studies have made little progress in being inclusive and representative. There remains a great need for including racial/ethnic minorities, low-income families, and pregnant women in research. The purpose of this article is to describe the implementation of enrollment strategies used in our study to understand the feasibility of building a maternal cohort and better understand the relationship between environmental and social impacts on maternal exposure and child outcomes.

Methods: Working across multiple academic units, …

Effect Of Prehabilitation On Functional Outcomes And Hospital Length Of Stay Following Total Joint Arthroplasty, Kristin Nicole Kaplewicz

Doctoral Dissertations and Projects

The purpose of this study was to determine how prehabilitation effects functional outcomes and length of stay in patients that have undergone total joint arthroplasties. Patients have continued to report being unhappy with their results of surgery and a large majority of the time is secondary to patients not being appropriately prepared for what to expect during their surgical recovery period. This information is important because occupational therapists and physical therapists continue to strive to improve patient satisfaction and outcomes. One of the ethical principles that healthcare providers commit to achieving is that of beneficence which means the clinicians must …

History Professors' Attitudes About Civil War Monument Removal: A Qualitative Study, Natania Y. Piper

Doctoral Dissertations and Projects

Violence in the United States is on the rise creating movements such as Black Lives Matter and others who call attention to ongoing racism in our country. One area of argument within the discussions of racism is the presence of Civil War monuments (CWMs) throughout the country. Many support the destruction, deconstruction, or relocation of these monuments, due to arguments that they are intended to demean and subjugate racial minorities. Others argue they do not carry this intent or meaning and are simply a memorial to former leaders. Little research exists that explores historian perspectives on this issue. The purpose …