Digital Commons Network^™

The Chanticleer, 2025-03-27, Coastal Carolina University

The Chanticleer Student Newspaper

The editorially independent student produced weekly newspaper of Coastal Carolina University.

March 2025 Academic Affairs Minutes, University Of Nebraska At Kearney Academic Affairs Committee

Academic Affairs Committee Minutes

No abstract provided.

Genomics Yields Biological And Phenotypic Insights Into Bipolar Disorder, Kevin S. O’Connell, Maria Koromina, Tracey Van Der Veen, Toni Boltz, Ney Alliey Rodriguez

School of Medicine Publications

Bipolar disorder is a leading contributor to the global burden of disease¹. Despite high heritability (60–80%), the majority of the underlying genetic determinants remain unknown². We analysed data from participants of European, East Asian, African American and Latino ancestries (n = 158,036 cases with bipolar disorder, 2.8 million controls), combining clinical, community and self-reported samples. We identified 298 genome-wide significant loci in the multi-ancestry meta-analysis, a fourfold increase over previous findings³, and identified an ancestry-specific association in the East Asian cohort. Integrating results from fine-mapping and other variant-to-gene mapping approaches identified 36 credible genes …

Inflammasomes Primarily Restrict Cytosolic Salmonella Replication Within Human Macrophages, Marisa S. Egan, E. A. O'Rourke, S. Kumar Mageswaran, B. Zuo, I. Martynyuk, T. Demissie, E. N. Hunter, A. R. Bass, Y.-W. Chang, I. E. Brodsky, S. Shin

Biology Faculty Works

Salmonella enterica serovar Typhimurium is a facultative intracellular pathogen that utilizes its type III secretion systems (T3SSs) to inject virulence factors into host cells and colonize the host. In turn, a subset of cytosolic immune receptors respond to T3SS ligands by forming multimeric signaling complexes called inflammasomes, which activate caspases that induce interleukin-1 (IL-1) family cytokine release and an inflammatory form of cell death called pyroptosis. Human macrophages mount a multifaceted inflammasome response to Salmonella infection that ultimately restricts intracellular bacterial replication. However, how inflammasomes restrict Salmonella replication remains unknown. We find that caspase-1 is essential for mediating inflammasome responses …

Efficacy Of Baits And Lures For Weasel Detection, Scott M. Bergeson, Roland Kays, David S. Jachowski, Courtney D. Anderson, Chad R. Williamson, Ashley Burket, Joseph W. Butfiloski, Amanda E. Cheeseman, Stacy Cotey, Catherine C. Dennison, John D. Erb, Zach J. Farris, Michael L. Fies, Michael J. Joyce, Colleen Olfenbuttel, Blake Sasse, Lisa M. Smith, Joshua A. Tabora, Marketa Zimova

Michigan Tech Publications

Small mustelids are difficult to survey due to their low density and cryptic nature. Population status of North American weasels (Mustela erminea, Mustela nivalis, and Neogale frenata) are believed to be in decline, but there are no standardized monitoring protocols to evaluate their status. To support weasel monitoring, we compared the attractiveness of various combinations of baits and lures to weasels in sites located throughout the eastern and central USA. We baited a total of 122 clusters of 4 camera traps, across 14 states, with random combinations of 4 baits and 3 scent lures in the winters of 2022 and …

Montana Kaimin, March 27, 2025, Students Of The University Of Montana, Missoula

Montana Kaimin, 1898-present

Student newspaper of the University of Montana, Missoula.

Computational Methods And Optimization For Naturalistic Functional Brain Mapping Using Diffuse Optical Tomography, Morgan Fogarty

McKelvey School of Engineering Graduate Student Theses & Dissertations

Naturalistic neuroimaging has significantly advanced our understanding of the brain in everyday situations. Stimulus designs that previously targeted individual brain regions are now being replaced by activities such as watching movies, engaging in conversations, and interacting with virtual reality environments. However, traditional functional neuroimaging techniques like functional magnetic resonance imaging (fMRI) are inherently unnaturalistic, as participants must lay down and remain still within the magnet's bore. Consequently, these naturalistic paradigms require an equally naturalistic neuroimaging modality. High-density diffuse optical tomography (HD-DOT) offers a wearable alternative to fMRI by utilizing overlapping optical measurements to densely sample cortical brain activity. HD-DOT has …

A Study To Identify The Causal Rare Genetic Variants In Primary Open And Closed Angle Glaucoma, Pseudoexfoliation Syndrome, And Associated Glaucoma, Suganya K

Theses and Dissertations

BACKGROUND: Glaucoma is the second most common cause of blindness globally typically diagnosed with a triad of clinical symptoms of increased intraocular pressure (IOP) with associated optic disc, optic nerve head (ONH) changes, and visual field defects. Genetic and environmental factors are some of the strong aetiology factors for glaucoma and identification of these factors has a potential implication in the management of the disease and its outcome. There is a paradigm shift towards understanding the genetics of glaucoma, wherein the variants in the nuclear, mitochondrial genome and other regulatory regions are being identified as contributing risk factors.

METHODOLOGY AND …

March 27, 2025, James Madison University

The Breeze, 2020-

The Breeze is the student newspaper of James Madison University in Harrisonburg, Virginia.

The Grizzly, March 27, 2025, Kate Horan, Renee Washart, Xazlee Carroll-Smith, Caitlin Cunnane, Emily Veasey, Adam Denn, Jesse Cherone

Ursinus College Grizzly Newspaper, 1978 to Present

Stand Up for Science Rally • Parlee Center Receives $3.2 Million Gift • Nowruz, the Persian New Year Celebration • Ritter Refresh • Breaking Biology Barriers • Opinion: "Who Are You, the Fashion Police?" • Wonderful Winter Stars! • Baseball's Successful Spring

Dynamic Gene Attention Focus (Dygaf): Enhancing Biomarker Identification Through Dual-Model Attention Networks, Md Khairul Islam, Himanshu Wagh, Hairong Wei

Michigan Tech Publications

The DyGAF model, which stands for Dynamic Gene Attention Focus, is specifically designed and tailored to address the challenges in biomarker detection, progression reporting of pathogen infection, and disease diagnostics. The DyGAF model introduced a novel dual-model attention-based mechanism within neural networks, combined with machine learning algorithms to enhance the process of biomarker identification. The model transcended traditional diagnostic approaches by meticulously analyzing gene expression data. DyGAF not only identified but also ranked genes based on their significance, revealing a comprehensive list of the top genes essential for disease detection and prognosis. In addition, KEGG pathways, Wiki Pathways, and Gene …

College Of Natural Sciences 2024 Year-End Publication, College Of Natural Sciences

College of Natural Sciences Newsletters and Reports

Page 2 Dean's Message
Page 3 Department Highlights
Page 4 One Day for State
Page 5 New Students in Wecota
Page 6-8 Faculty Excellence
Page 9 SDSU Physics Students Recognized
Page 9 Prairie Doc Watch Party
Page 10-11 Student Excellence
Page 11 Connections Abroad
Page 12-13 CNS’s Research Centers
Page 14 Connections Abroad
Page 14 Dean Wolf-Hall Retired
Page 15 Outreach Program
Page 15 Events and Traditions
Page 16 Student Spotlight
Page 17 Alumni Spotlight
Page 18-19 SDSU Alum at Paris Paralympics
Page 20 Work Anniversaries & Programs

Perceptions Of Artificial Intelligence (Ai) In The Construction Industry Among Undergraduate Construction Management Students: Case Study--A Study Of Future Leaders, Jonghoon Kim, Soomin Park, Sarah H. Moukhliss, Kwonsik Song, Dan Koo

Library Faculty Presentations & Publications

This study investigates the perceptions of artificial intelligence (AI) among undergraduate construction management students who are poised to become future leaders in the construction industry. As the industry increasingly adopts AI technologies to enhance project planning, design, site management, and safety, understanding students’ attitudes toward these innovations becomes crucial. This research employs a mixed-methods approach, combining quantitative survey data with qualitative data to capture the students’ insights on AI’s potential applications, benefits, and challenges within the construction sector. Findings indicate that while students recognize AI’s transformative potential to improve efficiency and safety in construction processes, they also express concerns regarding …

The Current - Volume 35 Issue 11, Nova Southeastern University

Student Newspapers

No abstract provided.

Phytochemical Analysis And In Vivo Anticancer Effect Of Becium Grandiflorum: Isolation And Characterization Of A Promising Cytotoxic Diterpene, Christeen Fahim, Maha R. A. Abdollah, Rola Milad, Nehal Sabry, Noha Swilam

Pharmacy

Background:Becium grandiflorum is a fragrant perennial shrub of the Lamiaceae family. Objectives: The current study aimed to explore the cytotoxic potential of the nhexane fraction from Becium grandiflorum aerial parts and, further, isolate its major diterpene and conduct in vitro and in vivo anticancer activities along with its molecular mechanism and synergy with doxorubicin. Methods: The hydroalcoholic extract of Becium grandiflorum aerial parts was fractionated, and the n-hexane fraction was analyzed via GC-MS. The major isolated diterpene, 18-epoxy-pimara-8(14),15-diene (epoxy-pimaradiene), was quantified using UPLC-PDA. Cytotoxicity assays were conducted on HCT-116, MCF-7, MDA-MB- 231, and HepG2 cell lines. The synergistic effect with …

Induced Mutagenesis In West Nile Virus Non-Structural Protein 3 With A Discussion Of The Mutation's Effects On Viral Properties, Caden Connealy

Honors Program: Senior Projects (Public)

West Nile Virus (WNV), a member of the Flaviviridae family and introduced to the Western hemisphere in 1999, presents a unique and emerging threat to human health. Infection in humans is often mild but can occasionally result in severe neurological impairment and even death. West Nile Virus non-structural protein 3 (NS3) plays an important role in the process of viral genome amplification. More specifically, the C-terminal domain of the protein folds into a helicase enzyme, which is responsible for the “unwinding” of double-stranded RNA intermediates and RNA secondary structure on the WNV genome. This is a vitally important step in …

Soft Robotic Brittle Star Shows The Influence Of Mass Distribution On Underwater Walking, Zach J. Patterson

Faculty Scholarship

Most walking organisms tend to have relatively light limbs and heavy bodies in order to facilitate rapid limb motion. However, the limbs of brittle stars (Class Ophiuroidea) are primarily comprised of dense skeletal elements, with potentially much higher mass and density compared to the body disk. To date, little is understood about how the relatively unique distribution of mass in these animals influences their locomotion. In this work, we use a brittle star inspired soft robot and computational modeling to examine how the distribution of mass and density in brittle stars affects their movement. The soft robot is fully untethered, …

Barriers And Breakthroughs In The Evolution Of Aggregative Multicellularity, Israt Jahan

Arts & Sciences Graduate Student Theses and Dissertations

The evolution of multicellular organization represents a key innovation in the history of life, yet fundamental questions remain about the evolutionary mechanisms that allowed some lineages to achieve remarkable complexity, while constrained others in their elaboration. The widely accepted single-cell bottleneck model provides a compelling explanation for the success of clonal multicellularity by reducing internal conflict and facilitating developmental integration. However, this perspective does not fully account for the stability and repeated evolution of aggregative multicellularity, where cooperation emerges among previously independent cells that may not be genetic relatives. Aggregative multicellularity demonstrates that the evolution of multicellularity is not a …

Barriers And Breakthroughs In The Evolution Of Aggregative Multicellularity, Israt Jahan

Arts & Sciences Graduate Student Theses and Dissertations

The evolution of multicellular organization represents a key innovation in the history of life, yet fundamental questions remain about the evolutionary mechanisms that allowed some lineages to achieve remarkable complexity, while constrained others in their elaboration. The widely accepted single-cell bottleneck model provides a compelling explanation for the success of clonal multicellularity by reducing internal conflict and facilitating developmental integration. However, this perspective does not fully account for the stability and repeated evolution of aggregative multicellularity, where cooperation emerges among previously independent cells that may not be genetic relatives. Aggregative multicellularity demonstrates that the evolution of multicellularity is not a …

The You Inside Of You: What Is The Nature Of The Soul?, The Philosophical Discussion Group

The Philosopher's Stone

• The The You Inside of You: What is the Nature of the Soul?

Computational Methods And Optimization For Naturalistic Functional Brain Mapping Using Diffuse Optical Tomography, Morgan Fogarty

McKelvey School of Engineering Graduate Student Theses & Dissertations

Naturalistic neuroimaging has significantly advanced our understanding of the brain in everyday situations. Stimulus designs that previously targeted individual brain regions are now being replaced by activities such as watching movies, engaging in conversations, and interacting with virtual reality environments. However, traditional functional neuroimaging techniques like functional magnetic resonance imaging (fMRI) are inherently unnaturalistic, as participants must lay down and remain still within the magnet's bore. Consequently, these naturalistic paradigms require an equally naturalistic neuroimaging modality. High-density diffuse optical tomography (HD-DOT) offers a wearable alternative to fMRI by utilizing overlapping optical measurements to densely sample cortical brain activity. HD-DOT has …

The Regulatory Triad: Reimagining Environmental Law In The Post-Chevron Era, Shai Stern, Itay Biton

Villanova Environmental Law Journal (1991 - )

No abstract provided.

Invasive Species From Sea To Shining Sea: An Exploration Of Different Government Responses To Invasive Species In The United States, Caroline G. Nelson

Villanova Environmental Law Journal (1991 - )

No abstract provided.

Management Of Parkinson's Disease Psychosis: First-Line Antipsychotic Selection And Rationale For Continuing, Combining, Or Switching, Stuart H. Isaacson, Henry Nasrallah, Rajesh Pahwa, Gustavo Alva, Daniel Kremens, Stephen M. Stahl

Department of Neurology Faculty Papers

INTRODUCTION: The past decade has seen a paradigm shift in the evaluation and management of Parkinson's disease psychosis (PDP), with the first approval of an antipsychotic in the US in 2016. An evidence-based review by the Movement Disorder Society found pimavanserin and clozapine to be clinically useful, (low-dose) quetiapine to be possibly useful, and all other antipsychotics to be avoided due to motor worsening. Clozapine and quetiapine use can be limited by provoking Parkinson's disease (PD) nonmotor symptoms of somnolence and hypotension. Quetiapine may also be limited by its risk in cognitive impairment. Pimavanserin is not associated with these symptoms. …

I&I - The Youth Sports Industrial Complex, Justin W. Angle

A New Angle Podcasts

In this episode of our Incentives & Instincts series, Justin and economist Bryce Ward revisit the youth sports industrial complex. They discuss how youth activities have evolved, the increasing pressure on families to overschedule their children, and the broader societal and economic forces driving these trends. The conversation explores the impact on kids' development, family life, and potential ways to rethink structured activities to create a healthier balance.

Identifying Herbicides To Manage Weeds In A Buckwheat Cover Crop And For The Control Of Volunteers, Taylor Randell-Singleton, Hannah E. Wright-Smith, Lavesta C. Hand, Jenna C. Vance, A. Stanley Culpepper

Horticulture Faculty Publications and Presentations

Buckwheat (Fagopyrum esculentum) is a fast-growing plant that quickly produces a dense groundcover. The utilization of buckwheat as a cover crop in vegetable production could be beneficial to Georgia producers, however for successful adoption, weed control in the cover crop coupled with control of buckwheat volunteers must be achievable. A preemergence (PRE) and a postemergence (POST) experiment were each conducted three times in Ty Ty, GA (2020-2021) addressing these objectives. In the PRE study, acetochlor at 0.56 lb ai acre(-1) injured buckwheat up to 16% without negatively influencing growth, suggesting potential for use in buckwheat for weed control. Flumioxazin, fomesafen, …

Maackia Amurensis Seed Lectin Structure And Sequence Comparison With Other M. Amurensis Lectins, Ashok R. Nayak, Cayla J. Holdcraft, Ariel C. Yin, Rachel E. Nicoletto, Caifeng Zhao, Haiyan Zheng, Dmitry Temiakov, Gary S. Goldberg

Department of Biochemistry and Molecular Biology Faculty Papers

Maackia amurensis lectins, including MASL, MAA, and MAL2, are widely utilized in biochemical and medicinal research. However, the structural and functional differences between these lectins have not been defined. Here, we present a high-resolution cryo-EM structure of MASL revealing that its tetrameric assembly is directed by two intersubunit disulfide bridges. These bridges, formed by C272 residues, are central to the dimer-of-dimers assembly of a MASL tetramer. This cryo-EM structure also identifies residues involved in stabilizing the dimer interface, multiple glycosylation sites, and calcium and manganese atoms in the sugar-binding pockets of MASL. Notably, our analysis reveals that Y250 in the …

The Prideful Ass: Using Augustine's Neoplatonic Theory Of Sin To Investigate Curiosity In Apuleius' Golden Ass, Danielle E. Booth

USF Tampa Graduate Theses and Dissertations

Ancient discourse about the beneficial yet predominantly dangerous role of curiosity inattaining knowledge was prevalent in the Roman Empire around the 2nd century C.E. when the North African author, Apuleius, composed his Latin novel, the Golden Ass. Although there is no shortage of modern scholarship that focuses on how Apuleius dramatizes obsessive intrigue by means of his protagonist, Lucius, contemporary publications seldom reorient the discussion to consider how unclear he is about the unstated source of curiosity, as I do in the following thesis. Approaching this topic through the context of ancient Neoplatonism, I argue Augustine of Hippo – a …

Awful, Yet Awe-Full: The Sublime Dystopia Of Blade Runner 2049, Charles E. Butt

USF Tampa Graduate Theses and Dissertations

Blockbuster dystopian sci-fi features stories of environmental collapse, authoritarian governments, out of control corporations, unbounded consumerism, and other awful possibilities. Scholars of science fiction broadly agree that this genre explores collective fears, anxieties, and speculations about the present and future. At the same time, film scholars have established that dystopian sci-fi cinema is compelling, and audiences respond to their effects-driven visuals, photorealistic mise-en-scene, and dramatic narratives. This creates an apparent paradox: Blockbuster cinematic aesthetics portray undesirable worlds desirably. I resolve this paradox by arguing that the worldbuilding of spectacle-driven, dystopian sci-fi cinema is Romanticized. That is, the provocative style of …

Left Ventricular And Aortic Pressures Measured With Fluid-Filled And Solid-State Pressure Catheters: Similarities And Differences, Priscilla Machado, Ira Cohen, Brian Osler, Maureen E. Mcdonald, Cara Esposito, Marguerite Davis, David Fischman, Michael P. Savage, Praveen Mehrotra, Flemming Forsberg, Jaydev K. Dave

Division of Cardiology Faculty Papers

Objective: To compare left ventricular (LV) and aortic (AO) pressures obtained using fluid-filled and high-fidelity solid-state pressure catheters in subjects undergoing left heart catheterization.

Materials and Methods: Twenty subjects scheduled for a left heart catheterization were enrolled and 18 subjects completed this IRB-approved study. LV and AO pressures were obtained using fluid-filled pressure catheter (standard-of-care) and high-fidelity solid-state pressure catheter synchronously. Pressure tracings were analyzed to measure LV systolic (LVSP), LV minimum-diastolic (LVMDP), LV end-diastolic (LVEDP), AO systolic (AOSP), and AO diastolic (AODP) pressures. Isovolumic contraction and relaxation rates (peak ± dp/dt) were derived from the pressure waveforms. Repeated measures …