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Alfred Russel Wallace Notes 36. Wallace, Evolution And Providence., Charles H. Smith Apr 2025

Alfred Russel Wallace Notes 36. Wallace, Evolution And Providence., Charles H. Smith

Faculty/Staff Personal Papers

One of Alfred Russel Wallace’s most important contributions to thought was his identification of the key role provident behavior assumes in human evolution. In this essay I set out the way this idea influenced his thought process after 1864, and especially how it affected his appreciation of the possible role of spiritualism in evolution.

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Consciousness And Fundamental Fine-Tuning: Brentanian Teleology Contra Agentive Cosmopsychism, Brandon Rickabaugh Apr 2025

Consciousness And Fundamental Fine-Tuning: Brentanian Teleology Contra Agentive Cosmopsychism, Brandon Rickabaugh

Faith and Philosophy: Journal of the Society of Christian Philosophers

No abstract provided.

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Testimony, Rationality, And Extended Cognition: The Magisterium And Moral Understanding, Stephen Napier Apr 2025

Testimony, Rationality, And Extended Cognition: The Magisterium And Moral Understanding, Stephen Napier

Faith and Philosophy: Journal of the Society of Christian Philosophers

No abstract provided.

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Measles Is Just A Harbinger, Catherine Troisi Apr 2025

Measles Is Just A Harbinger, Catherine Troisi

Faculty, Staff and Student Publications

No abstract provided.

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Policymakers’ Perceptions About Providing Affordable Housing In Rural Georgia, Robert Joseph Wiley Apr 2025

Policymakers’ Perceptions About Providing Affordable Housing In Rural Georgia, Robert Joseph Wiley

Walden Dissertations and Doctoral Studies

The literature showed that low-income households face a persistent deficit of affordable housing, forcing these families to live in dilapidated housing or to live beyond their means to pay for adequate housing, and that this problem transcends rural and urban counties. Further, researchers indicated that solving this problem provided a stable workforce and a better quality of life for all income groups. A gap in the literature showed the need for more research on nonmetropolitan communities addressing housing and neighborhood revitalization; therefore, through this qualitative multiple-case study local policymakers' perceptions of the affordable housing problem in rural Georgia were explored. …

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Commanders’ Perspectives On Training, Intervention, And Identity Adjustment For Reintegration, Chelsea Jones Apr 2025

Commanders’ Perspectives On Training, Intervention, And Identity Adjustment For Reintegration, Chelsea Jones

Walden Dissertations and Doctoral Studies

Military reintegration presents significant challenges for service members returning home to civilian life. Previous research has indicated many reintegration challenges, including reintegration preparation, identity adjustment, and proactive intervention; however, there remains an essential gap in the literature regarding training for military commanders and how they can be updated to help better facilitate service members’ reintegration. Grounded in general systems theory, the purpose of this qualitative study was to ask about the lived experiences of military commanders on reintegration preparation training, regarding proactive intervention during deployment, and about identity adjustment issues upon reintegration. The participants comprised six active and retired military …

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Ells’ Voices: Their Experiences About Wida Access Testing And Ways To Support Them, Maricris Treuenfels Apr 2025

Ells’ Voices: Their Experiences About Wida Access Testing And Ways To Support Them, Maricris Treuenfels

School of Education and Leadership Student Capstone Theses and Dissertations

This study investigated the lived experiences of 15 English Language Learners (ELLs) in relation to the annual WIDA ACCESS assessment. Using a mixed-methods design, the research combined quantitative survey responses with qualitative interview data to gain a more complete understanding of how students perceived the test and the supports provided to them. Findings revealed that participants often experienced anxiety before the test, felt confident during the test, and became nervous afterward. They expressed a need for clearer instructions, more practice opportunities, and a preference for paper-based testing. The study also emphasized the importance of culturally responsive instruction, consistent preparation, and …

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A Bioinformatic Analysis Of Foxo3 And Tgfb3 Variants: Possible Pathways To Survivin Expression, Elaine Vanterpool, Jordon Vanterpool Apr 2025

A Bioinformatic Analysis Of Foxo3 And Tgfb3 Variants: Possible Pathways To Survivin Expression, Elaine Vanterpool, Jordon Vanterpool

Student Posters

Worldwide, cancer is a major medical concern. Cancer may spread to your bones or organs through the lymphatic or circulatory systems. To have the best chance of recovery, it is crucial to get examined for cancer early. Numerous forms of cancer exist including breast, bone, brain, prostate, colon cancer, and etc. Survivin is a small inhibitor for apoptosis. Scientist consistently identify survivin being expressed in high tumor grade cancers by using molecular profiling analysis. Survivin has the potential to avail diagnosis. The goal of this study is to identify and investigate potential variants that are associated with the increased expression …

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Hydin Gene Variants: Implications In Primary Ciliary Dyskinesia And Other Diseases, Elaine Vanterpool, Sharie Angus Apr 2025

Hydin Gene Variants: Implications In Primary Ciliary Dyskinesia And Other Diseases, Elaine Vanterpool, Sharie Angus

Student Posters

The HYDIN gene, also known as CILD5, HYDIN1, HYDIN2, and PPP1R31, encodes a protein that plays a role in cilia motility. Mutations in HYDIN are associated with autosomal recessive primary ciliary dyskinesia-5 (PCD5), a disorder characterized by cerebrospinal fluid accumulation in the brain’s ventricles. A duplicate copy of this gene has also been identified on chromosome 1 in humans. Research indicates that HYDIN loss of-function mutations contribute to asthenoteratozoospermia, leading to structural defects in sperm flagella, disassembly of the acrosome and neck, and subsequent male infertility. Intracytoplasmic sperm injection (ICSI) has been proposed as a potential treatment for sperm immobility …

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Analysis Of Abca3 Variants Associated With Hypertension, Elaine Vanterpool, Ashlee Simpson Apr 2025

Analysis Of Abca3 Variants Associated With Hypertension, Elaine Vanterpool, Ashlee Simpson

Student Posters

Hypertension is abnormally high blood pressure in the arteries, the blood vessels that carry blood from the heart to the rest of the body. Many individuals do not know they have the condition. However, it is a major risk factor for a multitude of health problems. The heart and arteries having to work harder than normal thickens the muscles of the heart and arteries and hardens and damages artery walls. Flow of blood and oxygen is also reduced which directly results in heart disease. This study focuses on how the ABCA3 gene is associated with hypertension. The membrane-associated protein encoded …

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Mutations In The Mmp20 Gene In Association With Amelogenesis Imperfecta, Elaine Vanterpool, Alicia Myrie Apr 2025

Mutations In The Mmp20 Gene In Association With Amelogenesis Imperfecta, Elaine Vanterpool, Alicia Myrie

Student Posters

Amelogenesis Imperfecta or AI is a group of disorders that affect enamel formation and result in enamel abnormalities. One of the genes associated with these disorders is the MMP20 gene, which has instructions encoding for the protein enamelysin. Enamelysin, a predominant amelogenin-processing enzyme coded by MMP20 forms enamel by cleaving other proteins involved in its formation, making them easier to remove once they are no longer needed. These include: Amelogenin, Ameloblastin, and enamelin. Amelogenin makes up most of the enamel's extracellular matrix. Amelobastin deals with adhesion and cell signaling, along with aiding in structure. Enamelin is the largest protein in …

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Chek2 In Cancer Suppression: Investigating Genetic Variants And Their Impact, Elaine Vanterpool, Nicevarlyn Philippe Apr 2025

Chek2 In Cancer Suppression: Investigating Genetic Variants And Their Impact, Elaine Vanterpool, Nicevarlyn Philippe

Student Posters

Cancer develops when cells grow uncontrollably, often due to mutations in genes that maintain genome stability. One such gene is CHEK2 (Checkpoint Kinase 2), a tumor suppressor activated in response to DNA damage. CHEK2 halts the cell cycle to allow for DNA repair, stabilizes TP53, and phosphorylates BRCA1 , all of which help prevent the spread of mutations. CHEK2 belongs to the CDS1 family of serine/threonine kinases and contains an FHA domain that facilitates interaction with other DNA damage response proteins. Upon activation, CHEK2 inhibits CDC25C phosphatase, preventing premature mitosis, and contributes to G1 arrest through p53 stabilization. Itsrole in …

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Eed Gene Variants And Irritable Bowel Syndrome: A Genetic Approach To Understanding Ibs, Elaine Vanterpool, Ted Howard Apr 2025

Eed Gene Variants And Irritable Bowel Syndrome: A Genetic Approach To Understanding Ibs, Elaine Vanterpool, Ted Howard

Student Posters

Irritable Bowel Syndrome is a disease associated with the gastrointestinal tract that can cause abdominal discomfort, bloating, and alterations in the digestive tract. Its etiology remains complex, involving both genetic and environmental factors. Recent studies suggest that genetic variations may contribute to the pathogenesis of IBS. One such gene, the EED (Embryonic Ectoderm Development) gene, has been implicated in regulating various biological processes, including gene expression, cellular development, and gastrointestinal functions. In this research, we explore the potential relationship between the EED gene and IBS, with a focus on the variation rs798256, documented in the ClinVar database. We examine how …

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An Analysis Of Pon1 Variants Associated With Cardiovascular Disease (Cvd), Elaine Vanterpool, Adaiah Murray Apr 2025

An Analysis Of Pon1 Variants Associated With Cardiovascular Disease (Cvd), Elaine Vanterpool, Adaiah Murray

Student Posters

The PON1 gene encodes for paraoxonase 1, an enzyme that plays a crucial role in the breakdown of organophosphates and the prevention of oxidative damage to lipids, particularly those in low-density lipoprotein (LDL). PON1 is primarily associated with high-density lipoprotein (HDL), often called "good cholesterol," and is involved in antioxidant defense mechanisms. Cardiovascular Disease (CVD): The relationship between PON1 and cardiovascular disease has been a subject of considerable research. Variations in the PON1 gene and its product, paraoxonase 1, are important in modulating the risk of cardiovascular disease. The gene’s polymorphisms and their impact on enzyme activity may influence individual …

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The Analysis Of Thra Variants In Hypothyroidism, Elaine Vanterpool, Anaiah Mills Apr 2025

The Analysis Of Thra Variants In Hypothyroidism, Elaine Vanterpool, Anaiah Mills

Student Posters

Hypothyroidism is a chronic disease that lacks the production of thyroid hormones. If this disease is not treated with the proper care, it can lead to some serious health effects, or even become fatal. In hypothyroidism levels of thyroid hormones are low. The thyroid gland is a very pivotal part of the endocrine system located at the front of The protein encoded by this gene is the nuclear hormone receptor triiodothyronine. The consequences of untreated or inadequately treated hypothyroidism include infertility, cardiovascular disease, and neurological and musculoskeletal symptoms. Environmental iodine deficiency is the most common cause of thyroid disorders, including …

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The Analysis Of The Comt Gene Contribution To Schizophrenia, Elaine Vanterpool, Caelyn Mukorombindo Apr 2025

The Analysis Of The Comt Gene Contribution To Schizophrenia, Elaine Vanterpool, Caelyn Mukorombindo

Student Posters

The COMT gene, also known as the catechol-O-methyltransferase gene, plays a role in breaking down the neurotransmitters in the brain, like dopamine. Dopamine plays a role in behavior and mood; as a result, the COMT gene can influence traits like mental illnesses and disorders. COMT has a variation called Val158Met, where a change in the DNA sequence affects the efficiency of dopamine breakdown. Those who have the variant have lower COMT activity, which results in dopamine levels being high in the brain, which affects their ability to deal with stress and to show signs of aggressive behavior. This gene has …

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Bioinformatic Analysis Of Epcam Variants Associated With Colorectal Cancer, Elaine Vanterpool, Taylor Hall Apr 2025

Bioinformatic Analysis Of Epcam Variants Associated With Colorectal Cancer, Elaine Vanterpool, Taylor Hall

Student Posters

Colorectal cancer is the uncontrolled cell growth on the first and largest part of the intestine, the colon. Colorectal cancer, known as the “silent disease”, is easily undetected, especially in its early stages. It can be asymptomatic for years, and without the proper diagnosis, it can become fatal. Once symptoms start to appear, a patient can have rectal bleeding, fatigue, weight loss, changes in bowel habits, and more. Comprehending the pathogenesis of Colorectal cancer and enquiring about preventative measures against this disease requires awareness of the variants that play a part in this cancer. To start this study, we first …

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An Analysis Of Lamb3 Variants Associated With Amelogenesis Imperfecta, Elaine Vanterpool, Aaliyah Ruddock Apr 2025

An Analysis Of Lamb3 Variants Associated With Amelogenesis Imperfecta, Elaine Vanterpool, Aaliyah Ruddock

Student Posters

The disease researched in this study was Amelogenesis Imperfecta. Those infected may experience mild to extreme the enamel formation which results in tooth brittleness and discoloration (brown and yellow). Being an X-linked recessive inherited disease, it is more detrimental to males than that of females. Individuals with this disease are also more susceptible to dental caries caused by bacteria such as streptococcal mutans. Overtime, this bacteria can demineralize the teeth by metabolizing sugars that can produce acids. These acids can cause severe unrepairable damage to the tooth. This disease can also result in psychological issues including mental health disorders due …

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Analysis Of Rest Gene Variants Associated With Gingival Fibromatosis, Elaine Vanterpool, Daniellw Mills Apr 2025

Analysis Of Rest Gene Variants Associated With Gingival Fibromatosis, Elaine Vanterpool, Daniellw Mills

Student Posters

Gingival fibromatosis is a genetic disorder that affects cell proliferation of the gum tissue leading to excessive, benign growth of tissue in the mouth (1) . Like all genetic disorders this disease results from mutations in specific gene sequences responsible for proper protein expression (2). Geneticists are increasingly interested in studying the genes responsible for various diseases and the mutations that cause them (2). While significant study has been devoted to Gingival fibromatosis and the mutations that lead to it , there remains research to be done in alternate effects of various mutations in the genes responsible for the disease. …

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Genetic Insights Into Glaucoma: The Impact Of Tkb1 Mutations On Glaucoma, Elaine Vanterpool, Kelli-An Kindell Apr 2025

Genetic Insights Into Glaucoma: The Impact Of Tkb1 Mutations On Glaucoma, Elaine Vanterpool, Kelli-An Kindell

Student Posters

Glaucoma is a neurodegenerative eye disorder that can cause vision loss or permanent blindness due to damage in the optic nerve. Research has helped identify various genetic variants associated with this disease, including TBK1 (TANK-binding kinase 1). TBK1encodes for an enzyme serine/threonine which plays a role in innate immunity antiviral responses. This enzyme helps the immune system fight off infections by turning on specific signals in the body like IRF3/7 and NF-kB which regulate cytokine production and inflammatory response. Beyond immunity TBK1 is involved in crucial cellular processes including autophagy, mitochondrial energy production and cellular proliferation. TBK1 was linked to …

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An Analysis Of Dagla Variants Associated With Adhd, Elaine Vanterpool, Zahra Dulan Apr 2025

An Analysis Of Dagla Variants Associated With Adhd, Elaine Vanterpool, Zahra Dulan

Student Posters

The human genome is largely responsible for each individual’s unique physical and physiological development. It contains thousands of genes with multiple alleles that code for proteins with various functions. Mutations in these genes have the potential to lead to the development of human diseases and disorders. Therefore, properly analyzing mutated genes is essential to understanding their potential pathogenicity in various diseases and disorders. It may also provide a basis for the development of new therapies. The DAGLA gene encodes a protein called diacylglycerol lipase alpha. This enzyme is involved in the biosynthesis of 2-arachidonoyl-glycerol, a key player in the endocannabinoid …

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Analysis Of Tert Gene Associated With Melanoma, Elaine Vanterpool, Laila Prentice Apr 2025

Analysis Of Tert Gene Associated With Melanoma, Elaine Vanterpool, Laila Prentice

Student Posters

Melanoma is a type of skin cancer that arises when melanocytes, the pigment-producing cells in the skin, begin to proliferate uncontrollably. It can develop from a preexisting mole or previously unblemished skin. Melanoma is considered one of the most aggressive forms of skin cancer, known for its rapid proliferation and resistance to treatment. This malignancy poses a significant health risk to the elderly, who may be more susceptible due to cumulative sun exposure and age-related immune system decline. There are several subtypes of melanoma, including superficial spreading melanoma, nodular melanoma, lentigo maligna melanoma, and acral melanoma. Its development is strongly …

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An Analysis Of Abca3 Variants Associated With Hypertension, Elaine Vanterpool, Lisa-Faith Dieujuste Apr 2025

An Analysis Of Abca3 Variants Associated With Hypertension, Elaine Vanterpool, Lisa-Faith Dieujuste

Student Posters

blood pressure in the body is too high. A medical condition that is well known to be one of the major causes of premature deaths worldwide. Affecting an estimation of 1.28 billion adults . ABCA3 is a protein that is involved in the development of hypertension. ABCA3 is part of the ATP-binding cassette transporter family. It is a multi-membrane spanning protein meaning it has to do with the transporting, signaling and structure of cells. It plays a crucial role in the regulation of pulmonary surfactant homeostasis, but its main objective is to provide instruction to make protein that is involved …

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An Analysis Of Capn-10 Variants Associated With Polycystic Ovarian Syndrome, Elaine Vanterpool, Azaria Carey Apr 2025

An Analysis Of Capn-10 Variants Associated With Polycystic Ovarian Syndrome, Elaine Vanterpool, Azaria Carey

Student Posters

Calpain 10 (CAPN-10): A calcium independent protein in the calpain family involved in cell structure, signaling, and metabolism. oKey Functions: Regulates sugar metabolism, energy production, and insulin release, making it crucial for metabolic health. oType 2 Diabetes: CAPN-10 was the first gene linked to T2DM in the early 2000s. oGestational Diabetes: CAPN-10 variations contribute to insulin release and pancreas function, increasing risks for both mother and child. oPolycystic Ovary Syndrome (PCOS): CAPN-10 changes may exacerbate PCOS-related issues like insulin resistance, weight gain, and heart disease. o Purpose: to further clarify the role of CAPN-10 mutations in PCOS and their broader …

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Analysis Of Alzheimer's Associated Adam10 Mutations, Elaine Vanterpool, Addie Mciver Apr 2025

Analysis Of Alzheimer's Associated Adam10 Mutations, Elaine Vanterpool, Addie Mciver

Student Posters

Alzheimer’s Disease (AD) is characterized by a loss of short-term memory and deterioration of the brain through a decrease in neuron connection and damage to the cerebral cortex. The main symptoms of AD are confusion and a loss of memory, reasoning, and social behavior, partially believed to be caused by neuritic plaque accumulation. This debilitating disease is associated with 28 genes and 515 variants. One of the rarer genes, ADAM10, is a cell surface protein/ protease that is part of the alpha secretase family, commonly associated with AD. These genes, present in all mammals, code for others in the ADAM …

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Redbird Scholar, Vol. 10, No. 2 (Spring 2025), Illinois State University, Office Of The Vice President For Research And Graduate Studies Apr 2025

Redbird Scholar, Vol. 10, No. 2 (Spring 2025), Illinois State University, Office Of The Vice President For Research And Graduate Studies

Redbird Scholar

No abstract provided.

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Brain Specific Elevations Of Kynurenic Acid, Charles A. Grant Apr 2025

Brain Specific Elevations Of Kynurenic Acid, Charles A. Grant

Senior Theses

Individuals who suffer from neurocognitive disorders often suffer from sleep disturbances. Kynurenic acid (KYNA) is a tryptophan metabolite implicated in the pathophysiology of these disorders. Modest increases in KYNA, which acts as an antagonist at N-methyl-D-aspartate (NMDA) and α7 nicotinic acetylcholine (α7nACh) receptors, result in cognitive impairments and alterations in sleep-wake behavior. Specifically, KYNA negatively impacts rapid eye-movement (REM) sleep and increases wakefulness. The goals of the present project were to determine the impact of a dose response (0 µM, 1 µM, 3 µM, 10 µM; dissolved in PBS) elevation of KYNA locally in the brain. Wistar rats (N=10 female, …

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Assessing Bioactivity Of Green Leaf Volatiles In Various Plant Systems, Fallon S. Tomlin Apr 2025

Assessing Bioactivity Of Green Leaf Volatiles In Various Plant Systems, Fallon S. Tomlin

Senior Theses

Green leaf volatiles (GLVs) are chemical compounds essential in plant communication. Plants emit these volatiles due to abiotic and biotic stressors and, when perceived, these GLVs activate defense responses. Though GLVs play an important role in plant survival, it is still unknown where they localize, how they are perceived, and what structural factors influence perception. To elucidate these structural determinants, we tested the bioactivity of (Z)-3-fatty alcohols with four to nine carbons. Through root growth inhibition assays with tomato (Solanum peruvianum) seedlings, we found that (Z)-3-octenol and (Z)-3-nonenol were more bioactive than (Z)-3 hexenol and (Z)-3-heptenol. Thus, higher bioactivity was …

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The Reality Of Including Preventive Education Concepts To Reduce Risks And Crises In Social Studies Textbooks In The Sultanate Of Oman For Grades (3-12), Saif Nasser Al-Maamari, Awadh Al-Nassri, Muna Rashed Al-Na'aimi Apr 2025

The Reality Of Including Preventive Education Concepts To Reduce Risks And Crises In Social Studies Textbooks In The Sultanate Of Oman For Grades (3-12), Saif Nasser Al-Maamari, Awadh Al-Nassri, Muna Rashed Al-Na'aimi

Journal of Educational and Psychological Studies

The study aimed to identify the reality of including preventive education concepts to reduce risks and crises in social studies textbooks for grades from the third basic to the twelfth for post-basic education in the Sultanate of Oman. Use the descriptive analytical approach by following the content analysis method. The study included all social studies textbooks scheduled for the academic year (2023-2024). A list of preventive education concepts for risk and crisis reduction was prepared, which included five areas: concepts (causes, effects, prevention, recovery, management), which included (143) sub-concepts. Based on it, a comprehensive content analysis card was designed. After …

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An Investigation Of Selected Imprecations In The Old Testament In Light Of Recent Psychological Biblical Criticism, Uma John Apr 2025

An Investigation Of Selected Imprecations In The Old Testament In Light Of Recent Psychological Biblical Criticism, Uma John

ATS Dissertations

No abstract provided.

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