Digital Commons Network^™

Biomimetic Nanobots For Heavy Metal Soil Remediation, Suma Mallapragada, Vaishnavi Sankepally

Defensive Publications Series

This defensive publication introduces an innovative approach for heavy metal soil remediation using biomimetic nanobots, designed to autonomously detect, neutralize, and degrade harmful contaminants while ensuring eco-friendliness and sustainability. The nanobots feature a graphene-based outer capsule for structural durability, a gold nanolens for selective ion detection, and a bioengineered pseudo-organelle payload system that enables enzymatic neutralization of heavy metals. Utilizing optical-tweezer-based DNA-polystyrene actuators, the system is capable of movement within the soil, and a self-regenerating mechanism ensures prolonged activity. A NanoIoT-enabled communication system allows real-time monitoring and control with minimal human intervention. The nanobots target common …

The Utah Statesman, April 14, 2025, Utah State University

The Utah Statesman

Weekly student newspaper of Utah State University in Logan.

Tolkien, Tabletop, And Orcs: The Impact Of Participatory Neomedievalisms On Authority, Tyler Bell

ATU Theses and Dissertations 2021 - Present

Different medieval and fantasy works have utilized race in different ways. Medieval Europe used race as a structural relationship to morally and religiously other certain people groups. J.R.R. Tolkien used race in a similar way, othering the fantasy races like orcs as a way to give the audiences clear antagonists. Direct film and video game adaptations of Tolkien uphold him as the authority on fantasy race, using orcs as antagonists and glorifying violence against them. The table-top role-playing game Dungeons and Dragons initially held up the antagonistic portrayal of orcs, but through different editions, the restrictions placed on orcs have …

Detection Of Endocrine Disrupting Chemicals At The North Haven Water Pollution Control Facility On The Quinnipiac River, Kacey Daly

Honors Theses

The presence of estrogenic endocrine disrupting chemicals (EDCs) was detected using vacuum filtration and solid-phase extraction (SPE) followed by methods measured through chemical analysis. This research aims to quantify the presence of estrogenic EDCs in the Quinnipiac River located in Connecticut. Samples from influent, effluent, and downstream river locations from a Water Pollution Control Facility (WPCF) in North Haven, Connecticut are tested for the presence of estrone and 17α-ethinylestradiol. Findings from the study will provide insight to improve treatment efficiency of EDCs in WPCFs.

The Social Life Of Plants: Botanical Representations In Moche Art, Breanna Fae Reiss

Art & Art History ETDs

The Moche were semi-autonomous communities who thrived in the ten fertile riverine valleys of Peru’s northern coast between the late fourth and ninth centuries CE. Phase IV (c. 590–700 CE) Southern Moche ceramics feature intricate fine line visual narrative scenes with many multivalent symbols and motifs. This dissertation intends to understand why plants begin to play a more significant role in the Moche iconographic corpus in this period. I explore the interests of elites, the ecological web interweaving image and environment, and species identification. The local flora was affected on one hand by naturally occurring changes in weather and environment …

"Because He Was A Cripple": Collective Care And The Theory Of Complex Embodiment In Dickens's A Christmas Carol, Briley Wyckoff

Theses and Dissertations

Published in 1843, Charles Dickens's A Christmas Carol planted itself squarely into a society that depended upon physical labor and valued able-bodiedness. The crutch-bearing Tiny Tim is iconized for his angelic nature and positive outlook on his impairment, prompting critical conversation about narrative prosthesis and poster children, yet the other illustrations of disability in the novella are rarely explored. Contrary to the tendency of disability scholars to conclude that A Christmas Carol leans too heavily into the trope of inspirational disability or diminishes disabled agency, Dickens's incorporation of disability actually extends far beyond Tim as each member of the Cratchit …

Single-Entity Protein Electrochemistry Of A Diffusion-Limited Enzyme, Ziwen Zhao, Nikolaos Kostopoulos, Sagar Ganguli, Paul Bergstrom, Alina Sekretareva

Michigan Tech Publications

In this work, we present single-entity protein electrochemistry (SEPE) experiments on catalase, along with a theoretical model to simulate its enzymatic activity and predict the experimentally observed current responses. We perform SEPE measurements at various enzyme concentrations and use protein film voltammetry to investigate the origin of the observed electrochemical signals in SEPE. The modeling approach we develop combines finite element simulations in COMSOL Multiphysics with random walk simulations in MATLAB. The enzyme is represented as a partially active sphere, with an arc on the surface corresponding to the enzyme’s diffusion channel leading to the active site. Notably, the model …

Systematic Characterization Of The Homogeneous And Heterogeneous Hydrogen Halide Dimers, Yuan Xue, Gregory S. Tschumper

Chemistry Faculty Research & Creative Works

This study systematically characterizes the four homogeneous and six heterogeneous hydrogen-bonded dimers formed by hydrogen halide pairs (HX/HY where X, Y = F, Cl, Br, and I). The notation HX⋯HY indicates the direction of the hydrogen bond from the HY donor to the HX acceptor. All stationary points reported for these ten dimer systems are fully optimized utilizing the MP2 and CCSD(T) ab initio methods in conjunction with quadruple-ζ correlation-consistent basis sets augmented with diffuse functions, and their nature is verified by harmonic vibrational frequency computations. The electronic dissociation energies (De) for all ten global minima are evaluated near the …

Artificial Intelligence: In Your Phone And In Your Head, Gabrielle A. Johnson

ENGL 1102 Showcase

Artificial intelligence (AI) innovation has gained traction in recent years due to large investments towards improving the average person’s daily life. While operating the parent companies of common platforms such as Amazon, Instagram, and Microsoft, America’s richest citizens have spent billions on improving and researching the recent technology. AI offers ‘shortcuts’ to many daily inconveniences, fostering an over-reliance on the technology that has also led to human shortcomings. By using artificial intelligence, students can easily fill in homework answers with no calculations or critical thinking necessary. Beyond academics, relying on this technology compromises a broader necessity: human connection. With chatbots …

A Simple One‐Item Nursing Falls Assessment Predicts Outcomes For Patients With Stage D Heart Failure Undergoing Surgical Advanced Therapies, Thomas Joseph O'Neill Iv, Eiran Z. Gorodeski

Faculty Scholarship

Introduction: Frailty portends worse outcomes for patients with advanced heart failure (HF) undergoing surgical advanced therapies. Falls are characteristic of frailty, but it is unknown if the history of falls predicts post-operative risk. We hypothesized that a one-item fall screening is associated with worse outcomes. Methods: We conducted a retrospective study of all patients undergoing orthotopic heart transplantation (OHT) or left ventricular assist device (LVAD) implantation at our institution between 2020 and 2023. Our primary exposure of interest was falls, as assessed by a nursing questionnaire within 12 months or less prior to surgery. We tracked hospital- and ICU-length of …

Association Between High Triglyceride-Glucose Index And Macce In Hypertriglyceridemia Patients Undergoing Percutaneous Coronary Intervention, Yichuan Wang, Yanfeng Lu, Shanshan Gao, Zhong Zhong, Jasmine Bao, Bo Liu, Ruihan Fan, Ning Guo

SKMC Student Presentations and Publications

BACKGROUND: With a focus on metabolism-related cardiovascular diseases, the triglyceride-glucose (TyG) index has been used as a surrogate marker of insulin resistance in the prognosis of coronary heart disease. However, the prognostic role of the TyG index in patients with elevated triglycerides, still requires further research. This study aimed to investigate the association between the TyG index and Major Adverse Cardiac and Cerebrovascular Events (MACCE) in patients with hypertriglyceridemia undergoing drug-eluting stent percutaneous coronary intervention (DES-PCI).

METHODS: Out of 2250 patients, 813 with hypertriglyceridemia who underwent DES-PCI were retrospectively analyzed. MACCE was regarded as the primary endpoint. Kaplan-Meier (KM) curves …

Crow's Nest, April 14, 2025, Crow's Nest Staff

Crow's Nest

The April 14, 2025, issue of Crow's Nest.

The Daily Gamecock: April 2025, University Of South Carolina, Office Of Student Media

2025

No abstract provided.

Biology Department Publications: 2024, Sam Lindgren

Biology Department Bibliographies

This document is a non-comprehensive list of publications made by graduate students, post-doctoral researchers, and faculty members in the Biology Department in 2024. It indexes those publications available through PubMed, and serves as an archival record of the Department's robust scholarly contributions.

April 14, 2025

The Gavel Gazette

No abstract provided.

The Hill We Climb: A Mixed Methods Exploration Of Stress And Depression In A Community Sample, Akilah Collins-Anderson

Brown School Graduate Student Theses and Dissertations

While research on Black mental health has increased over the past decade, there remain strides to make with regard to the investigation of the relationship between stress and depression among Black Americans. For decades, stress process scholars have documented that negative, adverse experiences have consequences for mental health conditions, such as depression. Stress process theory predicts that greater exposure to stressors and limited access to coping resources increase the risk of poor mental health. Therefore, socially disadvantaged groups such as Black Americans would be expected to be at great risk of mental health conditions due to previous exposure to stressors. …

Mapping Mosquito Habitats With Girl Scouts: A Citizen Science Approach Using The “Mosquito Mission: Scout & Report!” Worksheet, Claire A. Klein

Honors Program: Senior Projects (Public)

Mosquitoes, though small, impact millions around the world by being significant vectors of diseases. The search for effective mosquito control efforts is ongoing, however, there is a gap in community involvement with a focus on recognizing and reducing potential breeding areas. Public engagement is a cornerstone of effective mosquito control. This honors thesis investigates the implementation of the Mosquito Mappers program with an original Girl Scout worksheet, “Mosquito Mission: Scout & Report!” This worksheet, which utilizes NASA’s GLOBE Observer Mosquito Habitat Mapper app, enables the Girl Scouts to contribute to real-time environmental monitoring. By guiding Girl Scouts through an inquiry-based …

Predicting Better Colostrum For Healthier Calves, Unh Communications And Public Affairs

UNH Today Archive

No abstract provided.

Direct And Mediating Relationships Between Divine Grace, Legalism, And Mental Health, Branwyn H. Mccormick

Senior Honors Theses

Positive psychology has popularized the integration of religious ideas into psychological treatment. According to the literature, the experience of divine grace is correlated with favorable mental health outcomes, whereas legalistic attitudes are correlated with adverse mental health outcomes. It has also been found that the experience of divine grace is a mediator between legalism and mental health. However, the constructs of divine grace and legalism have both been relatively unexplored aside from a few studies using Latter-day Saints (LDS) populations. The current study seeks to analyze relationships between divine grace, legalism, and mental health using a conservative evangelical Christian population. …

Germline Pathogenic Drosha Variants Are Linked To Pineoblastoma And Wilms Tumor Predisposition, Peter N Fiorica, Lisa Golmard, Jung Kim, Riyue Bao, Frank Y Lin, Angshumoy Roy, Allison Pribnow, Melissa R Perrino, Julien Masliah-Planchon, Sophie Michalak-Provost, Jennifer Wong, Mathilde Filser, Dominique Stoppa-Lyonnet, Franck Bourdeaut, Afane Brahimi, Olivier Ingster, Giselle Saulnier Sholler, Sarah A Jackson, Mark M Sasaki, Trent Fowler, Anita Ng, Ryan J Corbett, Rebecca S Kaufman, Jeremy S Haley, David J Carey, Kuan-Lin Huang, Sharon J Diskin, Jo Lynne Rokita, Hussam Al-Kateb, Rose B Mcgee, Joshua D Schiffman, Kenneth S Chen, Douglas R Stewart, D Williams Parsons, Sharon E Plon, Kris Ann P Schultz, Kenan Onel

Center for Medical Ethics and Health Policy Staff Publications

Purpose: DROSHA, DGCR8, and DICER1 regulate miRNA biogenesis and are commonly mutated in cancer. Although DGCR8 and DICER1 germline pathogenic variants (GPV) cause autosomal dominant tumor predisposition, no association between DROSHA GPVs and clinical phenotypes has been reported.

Experimental design: After obtaining informed consent, sequencing was performed on germline and tumor samples from all patients. The occurrence of germline DROSHA GPVs was investigated in large pediatric and adult cancer datasets. The population prevalence of DROSHA GPVs was investigated in the UK Biobank and Geisinger DiscovEHR cohorts.

Results: We describe nine children from eight families with heterozygous DROSHA GPVs and a …

Chimes: April 14, 2025, Calvin University

Chimes

Students lead pro-DEI protest on campus by Addy Offutt & Ethan Meyers

Men's tennis rallies with three straight sweeps; eyes MIAA title, shot at nationals by Zach Kern

Professors discuss effects of second Trump term by Grace Buller

"One God, Man Perspective" by Gregory Mox & Eric Rackard

" A Minecraft Movie" does its best to wreck my favorite thing by Marcail Schuurmann

Calvin's "Meet the Turtles" Event Aims to Connect Students with Nature and Community by Reuben Kok

Determinants Of Neuronal Viability Following Spreading Depolarization, Michael C. Bennett

Biomedical Sciences ETDs

Spreading depolarizations (SDs) are massive, slowly propagating waves that cause near-complete neuroglial depolarization and are energetically demanding for the brain. Past studies have established SDs as key contributors to secondary injury in tissue that lacks the metabolic supply to meet the energetic burden of repolarization after SD. Efforts to identify the mechanisms that cause deleterious consequences following SD have been ongoing, with significant results showing that blocking excitotoxic levels of Ca²⁺ from entering neurons through NMDA receptors prevents detrimental outcomes. While these studies have advanced the field, other mechanisms may also contribute to the metabolic burden of SD. This …

Bi-Allelic Variants In Brf2 Are Associated With Perinatal Death And Craniofacial Anomalies., Francesca Mattioli, Rún Friðriksdóttir, Anne Hebert, Sissy Bassani, Nazia Ibrahim, Shagufta Naz, Jacqueline Chrast, Clara Pailler-Pradeau, Ásmundur Oddsson, Patrick Sulem, Gisli H. Halldorsson, Páll Melsted, Daníel F. Guðbjartsson, Flavia Palombo, Tommaso Pippucci, Nayereh Nouri, Marco Seri, Emily G. Farrow, Carol J. Saunders, Nicolas Guex, Muhammad Ansar, Kari Stefansson, Alexandre Reymond

Manuscripts, Articles, Book Chapters and Other Papers

BACKGROUND: Variants in genes encoding multiple subunits of the RNA Polymerase III complex which synthesizes rRNAs, tRNAs, and other small RNAs were previously associated with neurological disorders, such as syndromic hypomyelination leukodystrophies, pontocerebellar hypoplasia, and cerebellofaciodental syndrome. One new such candidate is BRF2, which encodes a TFIIB-like factor that recruits the RNA polymerase III complex to type 3 promoters to initiate transcription of U6, RnaseP, and 7SK RNAs.

METHODS: We combined sequencing with functional analyses to investigate the effects of BRF2 variants.

RESULTS: We observe that a previously reported significant underrepresentation of double transmission of a splice variant results in …

Hexasodium Fytate (Snf472 Or Csl525) Inhibits Ectopic Calcification In Various Pseudoxanthoma Elasticum And Calcinosis Cutis Animal Models, Miguel Ferrer, Maria Pérez-Ferrer, Marc Blasco, Ida Jacobs, Qiaoli Li, Olivier Vanakker, Lisa Dangreau, Andrea López, Gianluca Malagraba, Firas Bassissi, Joan Perelló, Carolina Salcedo

Department of Biochemistry and Molecular Biology Faculty Papers

Background/Objectives: Ectopic calcification is a pathological condition characterized by the mineralization of soft tissues due to the deposition of calcium phosphate crystals. Hexasodium fytate (CSL525, previously known as SNF472) is a crystallization inhibitor being developed for the treatment of ectopic calcification-related disorders. Our aim was to investigate CSL525 for the treatment of soft-tissue calcification disorders in animal models of pseudoxanthoma elasticum and calcinosis cutis. Methods: In a first study, abcc6^-/- zebrafish larvae were exposed to 1 mM CSL525 for 7 days or kept under the same conditions without CSL525, and spinal mineralization was quantified. In a second study, abcc6 …

Long-Read Single-Cell Rna Sequencing Enables The Study Of Cancer Subclone-Specific Genotypes And Phenotypes In Chronic Lymphocytic Leukemia, Gage S Black, Xiaomeng Huang, Yi Qiao, Philip Moos, Deepa Sampath, Deborah M Stephens, Jennifer A Woyach, Gabor T Marth

Faculty, Staff and Student Publications

Bruton tyrosine kinase (BTK) inhibitors are effective for the treatment of chronic lymphocytic leukemia (CLL) due to BTK's role in B cell survival and proliferation. Treatment resistance is most commonly caused by the emergence of the hallmark BTKC481S mutation that inhibits drug binding. In this study, we aimed to investigate cancer subclones harboring a BTKC481S mutation and identify cells with co-occurring CLL driver mutations. In addition, we sought to determine whether BTK-mutated subclones exhibit distinct transcriptomic behavior when compared to other cancer subclones. To achieve these goals, we use scBayes, which integrates bulk DNA sequencing and single-cell …

Results Of The Phase I/Ii Study And Preliminary B-Cell Gene Signature Of Combined Inhibition Of Glutamine Metabolism And Egfr In Colorectal Cancer, Kristen K Ciombor, Seong-Woo Bae, Jennifer G Whisenant, Gregory D Ayers, Quanhu Sheng, Todd E Peterson, Gary T Smith, Kangyu Lin, Saikat Chowdhury, Preeti Kanikarla Marie, Alexey Sorokin, Allison S Cohen, Laura W Goff, Dana B Cardin, John Paul Shen, Scott Kopetz, Cathy Eng, Yu Shyr, Jordan Berlin, H Charles Manning

Faculty, Staff and Student Publications

Purpose: EGFR-targeting mAbs are essential for managing rat sarcoma virus wild-type metastatic colorectal cancer (mCRC), but their limited efficacy necessitates exploring immunologic and metabolic factors influencing response. This study evaluated glutamine metabolism targeting with EGFR inhibition to identify response biomarkers in patients with prior anti-EGFR treatment progression.

Patients and methods: We conducted a phase I/II trial in patients with KRAS wild-type mCRC, combining panitumumab (6 mg/kg) and CB-839 (600 mg/kg or 800 mg/kg), hypothesizing that the dual inhibition of glutamine metabolism and MAPK signaling would enhance outcomes. As study correlatives, we investigated the B-cell activation signature "B-score" and glutamine PET …

Closing The Gaps, And Improving Somatic Structural Variant Analysis And Benchmarking Using Chm13-T2t, Luis F Paulin, Jeremy Fan, Kieran O'Neill, Erin Pleasance, Vanessa L Porter, Steven J M Jones, Fritz J Sedlazeck

Faculty, Staff and Students Publications

The complexities of cancer genomes are becoming more easily interpreted due to advancements in sequencing technologies and improved bioinformatic analysis. Structural variants (SVs) represent an important subset of somatic events in tumors. While the detection of SVs has been markedly improved by the development of long-read sequencing, somatic variant identification and annotation remain challenging. We hypothesized that the use of a completed human reference genome (CHM13-T2T) would improve somatic SV calling. Our findings in a tumor-normal matched benchmark sample and three patient samples show that the CHM13-T2T improves SV detection accuracy compared to GRCh38 with a notable reduction in false-positive …

Somatodendritic Orientation Determines Tdcs-Induced Neuromodulation Of Purkinje Cell Activity In Awake Mice, Carlos A Sánchez-León, Guillermo Sánchez-Garrido Campos, Marta Fernández, Álvaro Sánchez-López, Javier F Medina, Javier Márquez-Ruiz

Faculty, Staff and Students Publications

Transcranial direct-current stimulation (tDCS) of the cerebellum is a promising non-invasive neuromodulatory technique being proposed for the treatment of neurological and neuropsychiatric disorders. However, there is a lack of knowledge about how externally applied currents affect neuronal spiking activity in cerebellar circuits in vivo. We investigated how Cb-tDCS affects the firing rate of Purkinje cells (PC) and non-PC in the mouse cerebellar cortex to understand the underlying mechanisms behind the polarity-dependent modulation of neuronal activity induced by tDCS. Mice (n=9) were prepared for the chronic recording of local field potentials (LFPs) to assess the actual electric field gradient imposed by …

Update On Cancer And Central Nervous System Tumor Surveillance In Pediatric Nf2-, Smarcb1-, And Lztr1-Related Schwannomatosis, Melissa R Perrino, Marjolijn C J Jongmans, Gail E Tomlinson, Mary-Louise C Greer, Sarah R Scollon, Sarah G Mitchell, Jordan R Hansford, Kris Ann P Schultz, Wendy K Kohlmann, Jennifer M Kalish, Suzanne P Macfarland, Anirban Das, Kara N Maxwell, Stefan M Pfister, Rosanna Weksberg, Orli Michaeli, Uri Tabori, Gina M Ney, Philip J Lupo, Jack J Brzezinski, Douglas R Stewart, Emma R Woodward, Christian P Kratz

Faculty, Staff and Students Publications

Schwannomatosis (SWN) is a distinct cancer predisposition syndrome caused by germline pathogenic variants in the genes NF2, SMARCB1, or LZTR1. There is a significant clinical overlap between these syndromes with the hallmark of increased risk for cranial, spinal, and peripheral schwannomas. Neurofibromatosis type 2 was recently renamed as NF2-related SWN and is the most common SWN syndrome, with increased risk for bilateral vestibular schwannomas, intradermal schwannomas, meningiomas, and less commonly, ependymoma. SMARCB1-related SWN is a familial SWN syndrome associated with peripheral and spinal schwannomas and an increased risk for meningiomas and malignant peripheral nerve sheath tumors, even in the absence …

A Hitchhiker’S Guide To Long-Read Genomic Analysis, Medhat Mahmoud, Daniel P Agustinho, Fritz J Sedlazeck

Faculty, Staff and Students Publications

Over the past decade, long-read sequencing has evolved into a pivotal technology for uncovering the hidden and complex regions of the genome. Significant cost efficiency, scalability, and accuracy advancements have driven this evolution. Concurrently, novel analytical methods have emerged to harness the full potential of long reads. These advancements have enabled milestones such as the first fully completed human genome, enhanced identification and understanding of complex genomic variants, and deeper insights into the interplay between epigenetics and genomic variation. This mini-review provides a comprehensive overview of the latest developments in long-read DNA sequencing analysis, encompassing reference-based and de novo assembly …