Digital Commons Network^™

Ensemble Learning With Explainable Ai For Improved Heart Disease Prediction Based On Multiple Datasets, Shahid Mohammad Ganie, Pijush Kanti Dutta Pramanik, Zhongming Zhao

Faculty, Staff and Student Publications

Heart disease is one of the leading causes of death worldwide. Predicting and detecting heart disease early is crucial, as it allows medical professionals to take appropriate and necessary actions at earlier stages. Healthcare professionals can diagnose cardiac conditions more accurately by applying machine learning technology. This study aimed to enhance heart disease prediction using stacking and voting ensemble methods. Fifteen base models were trained on two different heart disease datasets. After evaluating various combinations, six base models were pipelined to develop ensemble models employing a meta-model (stacking) and a majority vote (voting). The performance of the stacking and voting …

Optimizing A Perfusion-Compression Bioreactor Via Python Integration, Umamah Amer

Honors Theses

Bioreactors are widely used in tissue engineering to support cell and tissue growth under controlled conditions. Perfusion-compression bioreactors, like the one developed in our lab, can be used to replicate the physiological loading of bone on 3D-printed scaffolds. When seeded with osteogenic cells and subjected to mechanical loading, these scaffolds serve as a model to study osteogenesis. To simulate physiological conditions, the bioreactor must apply 1000 compression cycles at forces up to 200 N, three times daily over 14 days. Upon implementation, validation testing and experimental studies exposed several limitations in the bioreactor’s control code. The system was initially programmed …

Impacts Of Climate Change On Cannibalism And Disease Transmission In The Fall Armyworm, Kale Rougeau

LSU Master's Theses

Climate change may alter host-pathogen dynamics in terrestrial ecosystems due to rising global temperatures and carbon dioxide levels. Here, we examined cannibalism and disease transmission using the fall armyworm (Spodoptera frugiperda), an invasive agricultural pest, and its species-specific lethal baculovirus, Spodoptera frugiperda multiple nucleopolyhedrovirus (SfMNPV), under various potential challenges of climate change. We used three temperature treatments (cooler, optimal, warmer) based on the fall armyworm’s thermal performance curve to simulate a changing climate and four artificial diets with various protein-to-carbohydrate ratios (low, equal, high, standard) to manipulate resource quality from altered carbon dioxide levels. We found that higher …

Advancing Aerial Survey Techniques For Non-Breeding Waterfowl Populations: A Comprehensive Review And Application In Northeastern Louisiana, Victoria L. Drake

LSU Master's Theses

Aerial surveys play a crucial role in monitoring North America's waterfowl populations and habitat conditions, and consistency across geographies and years allows biologists to track trends through time. The goal of this project was to redesign the northeastern portion of the Louisiana wintering waterfowl survey to align with statistically robust transect surveys conducted in neighboring states within the Mississippi Alluvial Valley. To identify the optimal sampling method, we evaluated three transect weighting schemes: stratified random (unweighted), stratified by watershed, and stratified by expert opinion. Approximately 10% of the total sampling area was randomly selected for each survey period, adhering to …

Could Microplastics Impact The Ocean's Carbon Storage?, Rebecca Irelan

UNH Today Archive

No abstract provided.

Unveiling The Potential Of Urolithin A In Cancer Therapy: Mechanistic Insights To Future Perspectives Of Nanomedicine, Vinita Karumuru, Anupam Dhasmana, Narsimha Mamidi, Subhash Chauhan, Murali Yallapu

School of Medicine Publications

Cancer remains a leading global health challenge, with high mortality rates persisting despite significant advancements in therapeutic interventions. Major obstacles, including systemic toxicity, therapy resistance, metastasis, and relapses, emphasize the urgent need for safer, more effective, and readily accessible treatment strategies. Among emerging alternatives, natural bioactive compounds have gained considerable attention because of their diverse therapeutic potential and lower toxicity profiles. Urolithin A (UA), a metabolite derived from ellagic acid through gut microbiota metabolism, has emerged as a compelling anticancer agent. UA has multiple mechanisms of action, including the regulation of autophagy, enhancement of mitochondrial function, and inhibition of tumor …

Ecofriendly Synthesis And Characterization Of Oxygen-Enriched G-C3n4 From Diverse Precursors For Efficient Organic Dye Decontamination, Muchammad Tamyiz

Turkish Journal of Chemistry

Industrial wastewater from sectors such as textiles, printing, and pharmaceuticals contains harmful pollutants, including nonbiodegradable dyes, which pose significant challenges for environmental safety. Neutral red, a cationic dye commonly found in wastewater, obstructs photosynthesis in aquatic ecosystems and carries potential toxicity. Traditional methods of dye removal often prove ineffective due to the chemical stability of these compounds. In this study, oxygen-doped graphitic carbon nitride (O-doped g-C3N4) was synthesized as an innovative photocatalyst for the degradation of neutral red dye under visible light. The material was synthesized through a sustainable process involving the calcination of urea, dicyandiamide, and oxalic acid, and …

Risk Factors Of Self-Reported Prediabetes Status In New York State, Kari Ann Hunter Thompson

Walden Dissertations and Doctoral Studies

Prediabetes affects over 4 million people in New York State and increases the risk of Type 2 diabetes. Prior research identified risk factors such as poor diet, inactivity, obesity, hypertension, and smoking; but no studies examined these collectively or assessed their interactions. This quantitative, cross-sectional study analyzed a sample of 289 non-institutionalized adults aged 18 or older with landline or cellular phone, from the Behavioral Risk Factor Surveillance System. The study examined relationships between prediabetes and 16 factors in five categories: demographic (age, race, sex, education), socioeconomic (income, employment), behavioral (fruit intake, vegetable intake, physical activity, smoking), physiological (hypertension, BMI), …

Serological Detection Of Toxoplasma Gondii In Local Duck Birds, And Gallus Gallus In Basrah Province, Iraq, Ameer Ibrahim Abdulzahra, Alaa Ismail Saood, Afaq Talib Farhood

Baghdad Science Journal

Toxoplasma gondii was widely spread in humans and other animals, including domestic poultry, worldwide and depends on a unique collection of secretory and cytoskeletal organelles for host cell invasion. The meat of T. gondii infected poultry which includes chickens and ducks was widely consumed in most countries and was known as a primary source of human infection. In Iraq generally and in Basrah province especially, the prevalence of T. gondii in local ducks (Anas platyrhynchos domesticus) and domestic chicken (Gallus gallus) was scarcely known. In the current study, the Latex Agglutination Test (LAT) and (TOX) Toxoplasma IgM/IgG Antibody Rapid Test …

Characterization Of Kcl-Activated Carbon Derived From Walnut Shells Of Tidore Island, Indonesia, I Dewe Ketut Anom, Chaleb Paul Maanari, Marianus, Johny Zeth Lombok, Saprizal Hadisaputra, I Dewa Gede Katja, Jefry Jack Mamangkey, Aisyiah Restutiningsih Putri Utami

Baghdad Science Journal

Activated carbon is highly valued for its versatility and extensive industrial use. Walnut (Canarium vulgare Leech), an indigenous Indonesian plant primarily found in Eastern regions like Maluku and Tidore islands, produces shells that can be converted into activated carbon. This study involved obtaining carbon from walnut shells through pyrolysis at 360°C for 6 hours, followed by activation in a 3M KCl solution for 24 hours. The activated carbon was analyzed using Fourier Transform Infrared Spectroscopy (FTIR), Scanning Electron Microscopy-Energy Dispersive X-ray (SEM-EDX), and X-ray Diffraction (XRD). FTIR analysis revealed functional groups including N-H, Ar-H (aromatic), C≡N, carbonyl CO, and ester …

Implications For "Adjacent" Waterbodies After Sackett V. Epa, John C. Colson

Texas A&M Law Review

The Supreme Court’s recent ruling in Sackett v. EPA has rolled back Clean Water Act (“CWA”) protections for many wetlands on private property. Justice Kavanaugh’s little-commented-on concurrence identifies a class of waterbodies now unprotected by the CWA that nonetheless serves vital roles in flood control, pollution management, and habitat conservation. These waterbodies are those that lack a continuous surface connection (the majority’s test) to navigable waterways but are nonetheless “adjacent” to them in that they are separated by a single barrier. Including borrow pits and swamps held behind dikes, as well as the thousands of oxbow lakes near America’s rivers, …

Bog-Ged Down By Sackett: Strategies For Wetland Protection In Texas, Caleb Cook

Texas A&M Law Review

The Clean Water Act (“CWA”) has been one of the most powerful tools for protecting the nation’s waterways since it was first passed in 1972. However, there has long been ambiguity over the scope of the authority it grants for the regulation of wetlands. In May 2023, the Supreme Court resolved this question in Sackett v. Environmental Protection Agency. The effect of Sackett will be to remove significant amounts of previously regulated wetlands from federal jurisdiction. Federal legislative responses are unlikely, and while there are federal programs that can help temporarily fill the gap and bring some wetlands back …

Unique Stress, Cultural Resources, And Psychological Resilience In Young African American Women: Insights For Effective Intervention And Cvd Prevention, Sparkle Springfield-Trice, Cara Joyce, Penny Williams-Wolford, Dinishia Wolford, Destiny Onyeise, Natalie Battles, Dionne V. Milton, Chineze Mogbo, Raigine Robinson, Dave Stovall, Lena Hatchett, Ursula M. Staudinger

Biostatistics Collaborative Core: Faculty Publications and Other Works

Objective: Psychological resilience, defined as one’s self-reported ability to bounce back from stress, is understudied in young African American women (YAAW). Guided by community feedback, this study examined the associations between resilience and the following three constructs from Staudinger’s 2015 resilience and aging model: perceived stress, non-psychological resources, and psychological resources. We aimed to identify cultural resources that can enhance resilience in the face of unique stressors.

Methods: A cross-sectional survey was administered to 512 self-identified YAAW aged 18–35 years. Resilience was measured by the Brief Resilience Scale, ranging from one to five, with higher scores indicating greater resilience. We …

Maximizing Germination Of Three Native Plants For Rangeland Restoration And Urban Landscapes Through Seed Enhancements, Janetta Teichert

Theses and Dissertations

Native plants offer numerous ecological benefits and opportunities for both rangeland restoration and urban landscaping, making their integration essential for building sustainable ecosystems. They enhance soil health, promote pollinator activity, increase microbial diversity, and support both wildlife and livestock, all of which contribute to overall ecosystem resilience. A promising strategy to improve the use of native plants is the application of seed enhancement technologies, which can optimize seed germination, improve seedling establishment, and enhance overall plant success in challenging environments. These post-harvest seed treatments incorporate materials that improve seed performance, often through coatings composed of binders, fillers, and active ingredients. …

The George-Anne, Georgia Southern University

The George-Anne

• Honoring Freedom: A Bird of the People
• 'Hands off': Savannah Participates in Nationwide Protest
• Local Limelight: Welcome to the Southeast Punk Flea Market
• What students think of National Women's History Month
• Campus Fashion Highlights
• Savannah Celebrates 201st St. Patrick's Day Parade
• A Living Museum: The Botanic Garden at Georgia Southern University
• Petsboro
• Vault Apartments Declared "Unsafe Living Conditions": Off-Campus apartment declared Structurally Unsound
• Barnes & Noble Officially Transitions to University Store
• Consolidation of Georgia Southern and Easts Georgia State College Receives Approval

Molecular Changes, Histopathology, And Ultrasonic Vocalization Acoustic Profiles Of Systemically Dehydrated Rats, Brooke Rodgers, Naila Cannes Do Nascimento, Abigail Cox, Taylor W. Bailey, M. Preeti Sivasankar, Allison J. Schaser

Department of Speech, Language, and Hearing Sciences Faculty Publications

Systemic hydration is known to promote optimal functioning of bodily systems—including the vocal folds. The impact of systemic dehydration on the biology of the vocal folds and the downstream effects of dehydration on voice output are not well understood. An in vivo rat model of systemic dehydration was employed to investigate vocal fold gene expression, histological changes, and acoustic changes in vocalization. Ultrasonic vocalizations (USVs) were recorded every day for 5 days (baseline), in male and female Long-Evans rats (N = 36, ages: 3–4 months) using an anticipatory reward paradigm. Next, rats were dehydrated (N = 18) using a published …

Biallelic Fgf4 Variants Linked To Thoracic Dystrophy And Respiratory Insufficiency, Laura M. Watts, Esther Kinning, Donald R. Latner, Marla Johnston, Jessica Patrick-Esteve, Gregory M. Cooper, Stephen R.F. Twigg, Alistair T. Pagnamenta, Jenny C. Taylor

School of Medicine Faculty Publications

The thoracic dystrophies are inherited skeletal conditions where abnormal embryonic development of the thoracic skeleton results in a narrow chest, pulmonary hypoplasia, and respiratory insufficiency, which can be severe or lethal. The majority of thoracic dystrophies are due to biallelic alterations in genes needed for normal ciliary function. However, despite the identification of over 20 genes as causal for the thoracic dystrophy phenotype, around 20% of patients remain without a molecular diagnosis. We present two unrelated families with a clinical diagnosis of thoracic dystrophy with associated respiratory insufficiency without a molecular diagnosis on previous genetic testing. Both harbor rare biallelic …

Culturally And Linguistically Diverse Young Learners With Special Needs: Implementation Of The Resilience Based Interaction Model, Laura Knotts

Theses and Dissertations from DePaul University

No abstract provided.

College Sojourners' Reentry Experiences After Studying Abroad, Samantha Rose Maiolo

Honors Scholar Theses

When people think of studying abroad, they often think the experience ends when a study abroad participant returns home, but the reentry experience back home can be just as significant as the experience in the host country. In this study, I explored the following questions: (1) What emotional, social, and academic transitions do students experience when returning home from studying abroad? and (2) In what ways do the experiences students have abroad change their perspective of their life in the home culture? We interviewed 10 and surveyed 3 recent study abroad returnees from a large state university in New England. …

High-Pressure Excursion In Oxygenators During Adult Cardiopulmonary Bypass: A Scoping Review, Anne Nguyen

Student Works

Background: High-pressure excursions (HPE) in oxygenators during cardiopulmonary bypass (CPB) are rare but clinically significant events that can lead to compromised perfusion and adverse patient outcomes. HPE occurs due to fibrin and platelet deposition within the oxygenator, leading to increased transmembrane pressure and potential obstruction of blood flow. Despite its clinical importance, HPE remains an underrecognized issue with limited standardized guidelines for detection, prevention, and management.

Methods: A comprehensive literature search was conducted across multiple databases and grey literature sources to identify studies reporting on HPE in CPB oxygenators. The selection process followed the PRISMA-ScR framework, with articles screened based …

Evolutionary Biology In Latin America: Perspectives On Science, Religion And Society, Enrique Lessa

LAII Events

Tuesday, April 22,2025

(Castetter Hall 100 (219 Yale BIvd NE)

Join the LAll, the UNM Department of Biology, and the Guadalupe Institute for a discussion about evolutionary biology in Latin America.

Evolutionary biology has been at the center of conflicts between science and religion for the last two centuries. In Latin America, the relationship between science in general-and evolution in particular-and religion varies dramatically as a function of the history and profiles of the countries in the region. Post-truth radicalism globally is pushing anti-science sentiment to new extremes, and urgent, defensive and offensive action is needed. There is also a …

Inhibition Of Mif With An Allosteric Inhibitor Triggers Cell Cycle Arrest In Acute Myeloid Leukemia, Georgios Pantouris, Leepakshi Khurana, Pathricia Tilstam, Alison Benner, Thomas Yoonsang Cho, Martin Lelaidier, Mathieu Perrée, Zoe Rosenbaum, Lin Leng, Francine Foss, Vineet Bhandari, Amit Verma, Richard Bucala, Elias J. Lolis

Pacific Faculty Work

Macrophage migration inhibitory factor (MIF) is a key modulator of innate and adaptive immunity that has been extensively reported to promote tumor cell survival, proliferation, and metastasis. A recent study focusing on the microenvironment of acute myeloid leukemia (AML) showed that pharmacological inhibition of MIF signaling, in vitro as well as in vivo, reduces AML cell survival. Such data highlights the crucial role of MIF in AML pathogenesis and support the efforts for developing selective MIF modulators. Here, we report the identification and crystallographic characterization of a MIF inhibitor (compound 1) with an allosteric binding motif. Single point screening of …

Pyroptosis Of Pulmonary Fibroblasts And Macrophages Through Nlrc4 Inflammasome Leads To Acute Respiratory Failure, Yan Zhang, Guoying Zhang, Brittany Dong, Ankit Pandeya, Jian Cui, Samuel Dos Santos Valenca, Ling Yang, Jiaqian Qi, Zhuodong Chai, Congqing Wu, Daniel Kirchhofer, Toshihiko Shiroishi, Fadi Khasawneh, Min Tao, Feng Shao, Christopher M. Waters, Yinan Wei, Zhenyu Li

Chemistry Faculty Publications

The NAIP/NLRC4 inflammasome plays a pivotal role in the defense against bacterial infections, with its in vivo physiological function primarily recognized as driving inflammation in immune cells. Acute lung injury (ALI) is a leading cause of mortality in sepsis. In this study, we identify that the NAIP/NLRC4 inflammasome is highly expressed in both macrophages and pulmonary fibroblasts and that pyroptosis of these cells plays a critical role in lung injury. Mice challenged with gram-negative bacteria or flagellin developed lethal lung injury, characterized by reduced blood oxygen saturation, disrupted lung barrier function, and escalated inflammation. Flagellin-induced lung injury was protected in …

Speed Of Shear Waves As A Function Of Frequency In Micellar Fluid, Michael Basha

Honors Theses

The purpose of this experiment was to investigate the frequency dependence of shear wave speed in a micellar fluid. A high-concentration CTAB-NaSal micellar fluid seeded with microspheres was used in the experiment. Shear waves were generated using a wave driver and a function generator, while a high-speed camera captured video recordings. Since the frequency of the wave driver producing the shear waves in the micellar fluid is a constant value set by the experimenter, changes in shear wave speed can be determined by measuring their wavelengths at different frequencies.The captured video was then broken down into frames using MATLAB. These …

Complementary Self-Care Therapies To Self-Manage Endometriosis In Association With Health-Related Quality Of Life, Sarah Cummins

Walden Dissertations and Doctoral Studies

There is a lack of understanding within the psychological and medical communities on the extent to which endometriosis impacts the health-related quality of life (HRQoL) of people with endometriosis (PWE). This population is understudied in relation to the effects of endometriosis on HRQoL, the various methods used to treat and cope with endometriosis-related symptoms, the influence of self-managing endometriosis on PWE’s HRQoL, or the HRQoL outcomes associated with using nontraditional methods to self-manage endometriosis. As such, there is a lack of knowledge on the extent to which the use of various types of complementary self-care therapies to self-manage endometriosis is …

Promoting College And Career Ready Readers And Writers: A Guide For English, Science, And Social Studies Teachers To Support Instruction Of Sat Reading And Writing Skills, David Fitzpatrick

Masters Projects

In Michigan and across the United States, student scores on the Evidence Based Reading and Writing section of the SAT have been steadily declining. This project responds to this decline by developing a set of resources for skills-based literacy instruction that English language arts, social studies, and science teachers can use to revise their approaches to teaching literacy skills. Highly effective curriculum design and literacy instruction strategies were reviewed to design guides, templates, and models for practicing high school teachers at all grade levels to adapt in order to improve literacy instruction in their classrooms. By scaffolding literacy skills across …

Nash Equilibrium Solutions For Continuous Static Games Under Neutrosophic Environment, M. G. Brikaa

Neutrosophic Systems with Applications

Neutrosophic set theory plays an important role in dealing with the impreciseness and inconsistency in data encountered in solving real life problems. This paper presents a novel approach to solving a new class of continuous static games within a neutrosophic framework. In the proposed methodology, the neutrosophic continuous static games are redefined into two separate crisp problems: the lower problem and the upper problem. The study further establishes the necessary conditions for determining equilibrium strategies in neutrosophic continuous static games. To demonstrate its effectiveness and practical applicability, the proposed method is validated through a numerical example.

Tobacco Smoking Functional Networks: A Whole-Brain Connectome Analysis In 24 539 Individuals, Yezhi Pan, Chuan Bi, Zhenyao Ye, Hwiyoung Lee, Jiaao Yu, Luba Yammine, Tianzhou Ma, Peter Kochunov, L Elliot Hong, Shuo Chen

Faculty, Staff and Student Publications

Introduction: Nicotine addiction, a multifaceted neuropsychiatric disorder, profoundly impacts brain functions through interactions with neural pathways. Despite its significance, the impact of tobacco smoking on the whole-brain functional connectome remains largely unexplored.

Aims and methods: We conducted a whole-brain analysis on 24 539 adults aged 40 and above from the United Kingdom Biobank cohort. Subjects were categorized into individuals who use nicotine and those who do not use nicotine based on current and chronic tobacco smoking information. Functional connectivity was assessed using resting-state functional magnetic resonance imaging. We employed a network analysis method to assess the systematic effects of tobacco …

Can The Discovery Of High-Impact Diagnostics Be Improved By Matching The Sampling Rate Of Clinical Diagnostics To The Frequency Domain Of Diagnostic Information?, Steven W Millward, Peng Wei, David Piwnica-Worms, Seth T Gammon

Faculty, Staff and Student Publications

Over the past 30 years, academic and industrial research investigators have developed molecular reporters to visualize cell death in complex biological systems. In parallel, clinical researchers, chemists, biochemists, and molecular biologists have endeavored to translate these molecular tools into clinical imaging agents. Despite these efforts, there are no clinically approved imaging methodologies with which to image cell death consistently and quantitatively. One reason may reside in the intrinsic mismatch between the sampling frequency of translational molecular imaging and the biochemical kinetics that define cell death. Beyond cell death imaging, many active research programs are now attempting to create translational diagnostic …

Swi/Snf Complex-Mediated Znf410 Cooperative Binding Maintains Chromatin Accessibility And Enhancer Activity, Siyuan Xu, Chuxuan Peng, Ren Ren, Haowen Lu, Han Zhao, Sijian Xia, Yijie Shen, Bin Xu, Haoyue Zhang, Xiaodong Cheng, Gerd A Blobel, Xianjiang Lan

Faculty, Staff and Student Publications

The clustering of multiple transcription factor binding sites (TFBSs) for the same TF has proved to be a pervasive feature of cis-regulatory elements in the eukaryotic genome. However, the contribution of binding sites within the homotypic clusters of TFBSs (HCTs) to TF binding and target gene expression remains to be understood. Here, we characterize the CHD4 enhancers that harbor unique functional ZNF410 HCTs genome wide. We uncover that ZNF410 controls chromatin accessibility and activity of the CHD4 enhancer regions. We demonstrate that ZNF410 binds to the HCTs in a collaborative fashion, further conferring transcriptional activation. In particular, three ZNF410 motifs …