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The Different Effects Between Trimethylamine And Trimethylamine N-Oxide On H9c2 Myoblast Cells, Jessica Tiedeken, Ann Le, Juliet Melnik, Lindon H. Young, Robert J. Barsotti, Qian Chen

Research Day

Background: Trimethylamine (TMA) is a gut-derived metabolite of choline and L-carnitine that is converted to trimethylamine N-oxide (TMAO) in the liver. Elevated plasma TMAO levels are strongly associated with an increased risk of cardiovascular disease. Previous studies suggest that TMA and TMAO promote inflammation, oxidative stress, and dysregulation of cholesterol metabolism, contributing to pro-atherosclerotic changes in blood vessels. We hypothesize that high levels of TMA and TMAO induce cardiac cell damage through oxidative stress and mitochondrial dysfunction.

Goals/Methods: This study utilizes H9c2 myoblast cells to investigate the effects of TMA and TMAO on cardiac cell function. Cells were treated with …

A Mesocosm Experiment On The Impact Of Competition With Native Pickerelweed (Pontederia Cordata) And Invasive Cattail (Typha X Glauca) On The Growth Of Northern Wild Rice (Zizania Palustris), Megan Wenner

Undergraduate Research and Engagement Symposium

Northern wild rice (Zizania palustris; manoomin/Mnomen in Anishinaabemowin; ZP) is an annual emergent macrophyte of cultural and economic significance to many North American indigenous tribal nations. Its present extent throughout its native Great Lakes region is much reduced. Competition with other wetland plants may significantly reduce ZP growth and survival. Most ZP competitors are perennial plants, whose established rhizomes persist in the sediment, granting a head-start on growth each year. This mesocosm experiment investigated how competition with hybrid cattail (Typha x glauca) and pickerelweed (Pontederia cordata) – dominant invasive and native rhizomatous species, respectively – impacted ZP growth.

Analysis Of Β-Glucosidase Mutant T352v, John Ratz, Sufia Khan

Undergraduate Research and Engagement Symposium

This study looks at mutant T352V Β-glucosidase B (BglB). The mutant product was hypothesized to show reduced kinetic activity and thermostability compared to the wild-type. This was determined through modeling of the mutation using the FoldIt software. The protein was then purified and expressed through SDS-PAGE and Western Blotting. The results indicate that there was no production of a soluble protein. However, the Western Blot indicates the production of an insoluble protein. FoldIt modeling helps to explain the insoluble protein, as it indicates that the proximity of molecules without binding could cause aggregates to form inclusion bodies.

Symbolic Significance Of Pachuco And Teddy Boy Fashion, Mya Abuzir

Undergraduate Research and Engagement Symposium

This poster examines how self-presentation among Pachucos and Teddy Boys subcultures served as a claim for recognition and a form of protest. By analyzing both subgroups’ formation and key elements to the style itself, I argue how their self-presentation represents the making of a claim to their historical and socioeconomic contexts. My hypothesis suggests that these distinct sartorial choices reflect collective discontent and critiques of social and political injustices. This supports the argument that making a political or moral claim is beyond discursive articulation and that one can express said claims outwardly through clothing choices, hairstyles, and makeup.

Assessing The Molecular Conservation Of The Gene Mipp2 Across Drosophila Species, Mya Abuzir

Undergraduate Research and Engagement Symposium

The primary objective of this project is to assess the molecular and structural conservation of Mipp2 within the insulin signaling pathway, across various Drosophila species. We mapped the location of Mipp2 in D. arizonae and annotated its coding sequences. The annotation displayed poor conservation of Mipp2 between D. melanogaster and D. arizonae, showing divergence in all coding exons. We have since annotated Mipp2 across additional Drosophila species and have found that more closely related species exhibit higher conservation of the gene region and the protein coding sequence.

The Role Of Shot In Spermatogenesis, Maya Petryszak

Undergraduate Research and Engagement Symposium

The biological process known as spermatogenesis is how sperm cells develop. Our study looks at the role of the short stop (shot) protein, which encodes a spectraplakin protein involved in regulating microtubules and actin. Shot’s function in Drosophila ovaries is well-known, but its role in spermatogenesis remains unexplored. Given the importance of microtubules and actin in sperm maturation, we believe that Shot coordinates their activity in the testes. To research this, we reduced Shot protein levels in testes somatic cells using RNA interference (RNAi) and GAL4/UAS system. By crossing tj-Gal4 flies with UAS-shot-RNAi flies, we can examine the effects of …

Shared Responsibility In Medical Aid In Dying (Maid): An Exploration Of The Ethical Implications Of Patient, Physician, And Familial Roles, Aseel Taha, Bre Mccoy, Mariam Sohail, Sanjitha Boobalan

Undergraduate Research and Engagement Symposium

Contrary to common perceptions surrounding death, the act of dying is often a social process. This poster explores the ethical implications of decision-making in Medical Aid in Dying (MAID), specifically looking at the role that family members and loved ones play when a patient decides to undergo MAID processes. The following research questions will be explored in this poster: What impact does participation in MAID processes have on familial networks? What internal turmoil do family members experience in their active involvement in MAID, and what motivates them to overlook such turmoil and choose to help? What makes end-of-life processes go …

Pyrazole-Based Inhibitors Of The Bacterial Enzyme Dape As Potential Antibiotics, Alayna Bland, Emma H. Kelley, Thomas Dipuma, Teerana Thabthimthong, Daniel P. Becker

Undergraduate Research and Engagement Symposium

As bacteria become increasingly resistant to antibiotics, there is a need for new antibiotics using alternative pathways. To answer this need, our research investigates inhibitors of the bacterial enzyme N-succinyl-L,L-2,6-diaminopimelic acid desuccinylase (DapE). Based on previous work, we focused on pyrazole-based inhibitors, which were tested using a ninhydrin-based assay. The most potent pyrazole analog, 7d, has an IC₅₀ of 17.9 ± 8.0 µM, and analog (R)-7q is a competitive inhibitor with an IC₅₀ of 18.8 µM. A thermal shift assay demonstrated stabilization of the enzyme after binding with inhibitor (R)-7q …

Pollinator And Pollinator Plant Communities Within Restored Montane Longleaf Pine Ecosystems, Hanen Van Rossem, Matthew Weand

Symposium of Student Scholars

Historically the fire-dependent and biodiverse longleaf pine (Pinus palustris) ecosystem was the dominant ecosystem of the Southeastern US. This ecosystem’s range was massively reduced due to land conversion and fire exclusion, causing the decline of many native species. Efforts to restore and protect longleaf pine stands are now ongoing with the goal of expanding habitat and refuge for threatened species. Differences in restoration practices and prior land use may influence the extent to which restored habitat patches can support pollinators and their plants. This study compared pollinator plant biodiversity between restored neighboring montane longleaf pine stands that differed in …

Enhancing Patient Safety: Exploring Virtual Sitters' Role In Fall Prevention Through Remote Virtual Monitoring, Adama Diallo, Awatef Ergai Dr., Leeanna Spiva Dr., Meriel Mccollum Dr.

Symposium of Student Scholars

Remote Virtual Monitoring (RVM) technology enhances safety for both patients and care teams by reducing falls, improving the efficiency and effectiveness of continuous patient observation, and lowering costs associated with falls and staff support. The success of fall reduction efforts largely depends on the role of virtual sitters, individuals who remotely monitor high-risk patients to prevent falls. This study aims to explore the experiences of virtual sitters, identifying key themes, challenges, and opportunities to improve the intervention. Specifically, the research investigates how technology, work shifts, and institutional support impact the effectiveness and job satisfaction of virtual sitters.

Structure Disorder And Magnetic Behavior Of An Olivine-Type Cathode Material, Hamida Hassan, Madalynn Marshall

Symposium of Student Scholars

Our research investigates the structure disorder and magnetic behavior of Li(Mn,Fe)PO₄, an olivine-type material relevant for lithium-ion battery applications. Using single-crystal neutron diffraction at Oak Ridge National Laboratory, we precisely determined Mn and Fe occupancy, revealing a 56% Fe and 44% Mn distribution at the atomic 4c site within the Pnma space group. Additionally, we observed significant lithium site vacancies (78% occupied), influencing the material's electrochemical and magnetic properties. The varying Mn/Fe ratio affected spin reorientation transitions, shifting from antiferromagnetic alignment along the a-axis to the b-axis. Our findings provide crucial insights for optimizing olivine-based cathodes, enhancing energy …

Computational Study Of The Proton Transfer In The H7o3+ Cluster, Anna James, Martina Kaledin

Symposium of Student Scholars

Proton transfer (PT) from one molecule to another is among the most studied phenomena in chemistry. PT requires the bond cleavage and the formation of a new one, AH⁺ + B -> A+ BH⁺. In protonated water clusters, such a process consists of the interconversion of hydrogen bonds. Experimentally, such a process can be observed as a significant increase of a dipole moment. However, other vibrational transitions often occur with small changes in the dipole moment while large changes in polarizability. In this work, we study the PT process in a protonated water cluster, H₇O …

Assessing The Osmoregulatory Capabilities Of American Alligator Lingual Glands, Benjamin Angalet, Nicholas S. Green

Symposium of Student Scholars

Crocodilians inhabit a wide variety of aquatic, marine, and estuarine habitats on 4 continents. Saltwater-adapted species and populations face considerable osmoregulatory challenges in maintaining homeostasis with respect to plasma salt [NaCl] concentration. In addition to the kidneys and cloaca found in all crocodilians, crocodiles possess a salt-secreting lingual gland whose presence and function is less understood in other crocodilians. This study investigates the lingual gland anatomy, physiology, and potential function of American alligator (Alligator mississippiensis) populations exposed to varying salinity levels. At each of four sites (Jekyll Island, Sapelo Island, Okefenokee NWR, and Banks Lake NWR), we will capture 12 …

Investigating The Impact Of Waterhead, Time And Temperature On Dam Displacement: Application Of Computer Aided Models, Maaz Abdullah

AUIQ Technical Engineering Science

Dam displacement is a crucial indicator for assessing the safety of a concrete dam through structural health monitoring. Since the displacement data exhibits a non-linear and complex relationship with influencing factors like waterhead, time and temperature, machine learning models are deployed to accurately predict dam displacement. Furthermore, the limited availability of monitored data in the majority of the dams renders the studies conducted with a large number of observations valueless. In order to address the aforementioned issues, this study proposes a feature selection approach to predict dam displacement by examining the ability of four ensemble machine learning models on different …

Surface Urban Heat Island Effects Analysis In The Most Populated City In Thailand: Towards Sustainable Urban Development, Abdul Maulud Khairul Nizam, Muhammad Noor, Zafar Iqbal

AUIQ Technical Engineering Science

The fast and unprecedented urban growth process may violate cities' responsibilities by causing an urban heat island (UHI) and increasing the public's risk of heat-related illnesses due to vegetative area reduction and urban area inclination. The Bangkok Metropolitan Area (BMA)'s variations in Land Use Land Cover (LULC), Land Surface Temperature (LST), UHI, and several geospatial indicators, as well as the daytime and nighttime LST, are the main subjects of the study. Between 2015 and 2021, the highest Daytime LST (DLST) rose consistently from 36.77°C to 38.14°C, then slightly decreased to 37.22°C in 2023. There is a general increase in the …

A Comprehensive Review Of Advancements In Materials And Manufacturing For 3d Knee Implants, Huda Ali Hashim, Ghaidaa A. Khalid

AUIQ Technical Engineering Science

Over the past three decades, knee implant design has significantly advanced to address the challenges of replacing damaged knee joint bone with durable and efficient prosthetics. The aim of this review explore key developments in materials and manufacturing processes, focusing on biocompatible options such as zirconium, titanium alloys, UHMWP, and smart materials, as well as coatings designed for metal-sensitive patients. The study examines the mechanical forces acting on implants during daily activities, highlighting wear and infection risks, and evaluates the role of innovative manufacturing techniques in improving implant precision, cost-efficiency, and durability. Simulation methods, including Finite Element Analysis (FEA), are …

Wide Band Single-Mode Optical Fiber Design For Decreasing Bending Loss, Zahraa M. Kassem Alasady, Ahmed Al-Amiery

AUIQ Technical Engineering Science

Radiation loss due to fiber curving or bending is a major challenge in advanced technical applications like fiber-optic sensing or biomedical applications. This study focuses on the basic features that characterize a single-mode fiber (SMF) and its critical parameters in view of the recent improvements made. The planned design of SMF is, however, intended to resolve these problems by proposing minimizing bend loss by adopting a five-layer fiber structure designed to keep the optical field within the fiber core. The proposed SMF design exhibit ultra-low bending sensitivity, with estimated bending loss of 2×10-3 dB/turn for bending radius of 5 mm. …

Can A Ceh-27/Nkx2.1 Transgene Rescue Ceh-27 Neurodevelopmental Defects?, Meryl Gilmore, Martin L. Hudson

Symposium of Student Scholars

When the development of an organism’s nervous system is interrupted or altered, it can significantly impact that organism’s ability to survive and function properly. In our lab, we use a species of nematode called Caenorhabditis elegans as a model organism to characterize the roles of important transcription factors in human neurodevelopmental disorders such as attention deficit hyperactivity disorder (ADHD). Utilizing C. elegans makes analyzing this process in a lab very easy for many reasons; they are very small, have a rapid life cycle, invariant cell lineage, transparent bodies, and most importantly, around 80% of their genes have human orthologs. In …

Properties Of Eigenvalues Of The Fractal Laplacian, Eric Stachura, Andrew Chincea

Symposium of Student Scholars

We investigate the properties of the eigenvalues of the fractal Laplacian. We begin by defining the fractal Laplacian operator in one dimension and formulate the corresponding Dirichlet eigenvalue problem. Analytical solutions are obtained for specific fractal parameters, and computational results illustrate the structure of eigenvalues and their associated eigenfunctions. We extend our analysis to two dimensions using separation of variables. Our findings contribute to a deeper understanding of how fractal geometry affects the spectral characteristics of differential operators.

Hands-On Healing: The Role Of Creative Art And Clay In Happiness And Stress Reduction, Aria Mokhtari, Mahdi Ghasemi, Melika Eshaghian, Kat Bishop, Brittany Turner, Ryan Golshir, Ana De Faria Lima, Kaylee Stone, Soojin Lee, Jennifer Cooper

Symposium of Student Scholars

Stress and mental health concerns are increasing among students at Kennesaw State University. Creativity has gained recognition for their therapeutic benefits. This research investigated the impact of clay sculpting on stress reduction and emotional well-being. Through qualitative and quantitative assessments, we analyzed participants' self-reported stress levels before and after participating in clay sculpting. A pre-and post-event survey measured the impact of engagement in these activities. After evaluating feedback and statistical trends, this study can provide evidence supporting clay sculpting as an effective tool for enhancing mental well-being among students. Stress levels were assessed using numerical rating scales (a form of …

Renal Protection By Upadacitinib In Ischemia-Reperfusion Injury: Insights From A Male Rat Model", Furqan Hashim Hussein, Najah R. Al Mosawi

Maaen Journal for Medical Sciences

Renal ischemia reperfusion damage is a severe syndrome that can develop after kidney transplants, kidney-targeting surgery, or other clinical situations that restrict blood flow to the kidneys. This study evaluated the effectiveness of the JAK1 inhibitor upadacitinib in lowering RIRI in a rat model. The rats were stratified into 4 groups after a 1 week acclimatization period. The study found that HMGBox and inflammatory substances like TNF-α and IL-6 impact RIRI. Upadacitinib's inhibition of the JAK1/STAT3 pathway minimized RIRI by significantly lowering these molecules. It also significantly reduced NF-κB activation, thereby reducing the inflammatory response and programmed cell death. The …

An Examination Of Health Coaching As A Developing Profession, Katie Suleta, Jonathan M. Davis

HCA Healthcare Journal of Medicine

Background

Health coaching is a field that is growing in popularity. Health coaching is not regulated and there is no standard for background, education, or training for those acting as health coaches. The purpose of this study was to investigate the burgeoning field of health coaching: who is performing it and common practices.

Methods

A total of 560 health coaching websites were reviewed to record educational backgrounds, recommendations for supplements, and the sale of supplements and/or other wellness products. Multivariable logistic regression was used to test associations between characteristics of health coaches and whether they recommend supplements, sell supplements, or …

Utility Of Incorporating Radiological Findings Of Right Heart Strain In Patients With Acute Pulmonary Embolism For Risk Stratification Of Adverse Outcomes: A Retrospective Analysis, Joshua Amaya, Sameer Allahabadi, Daniel L. Habenicht, John Hunton, Amal M. Khan, Subhash Venigalla, Curran Reddy, Jeremy V. Doan, Grace Wang, Daniel R. Eickenhorst, Shovendra Gautam

HCA Healthcare Journal of Medicine

Background

Right heart (RH) strain in the setting of pulmonary embolisms can significantly increase the risk of mortality. Thus, screening for risk of complications in these patients is crucial. The goal of our study was to assess the strength of specific diagnostic findings of RH strain for predicting adverse outcomes including mortality, hospital length of stay, and the requirement of advanced interventions.

Methods

A single-center, retrospective cohort study of 81 patients diagnosed with acute pulmonary embolism with RH strain on computed tomography pulmonary angiogram (CTPA) from September 12, 2019, to August 30, 2023. Data were collected on patient computed tomography …

Education For Young People In A World Full Of Uncertainty, Elizabeth Kristi Poerwandari

Psychological Research on Urban Society

Education for Young People in a World Full of Uncertainty

Predicting Healthcare Service Quality Based On A Kalman-Optimized Bi-Lstm-Inspired Deep Learning Model, Mohammed K. Al-Khafaji, Eman S. Al-Shamery

Karbala International Journal of Modern Science

Health is one of the most important aspects of human well-being, and access to high-quality healthcare is essential for a good quality of life. Providing top-level health services at all times is crucial. However, the research in healthcare poses significant challenges due to the diversity and variations of medical practices across different hospitals. This paper aims to tackle the challenge of data missing and scattering during data collection. Then, the quality of services (QoS) offered by healthcare facilities will be analyzed and predicted from the patient's perspective. The model begins preprocessing data by data cleaning, handling missing values, and scattering …

Contrasting Patients' And Healthcare Professionals' Experience In Hematological Cancer Care Pathway: A Narrative Study, Karine Bilodeau, Cynthia Henriksen, Camilia Aloisio Alves, Charlotte Gélinas-Gagné, Lynda Piché, Jacinthe Pepin, Virginia Lee, Marie-France Vachon, Nathalie Folch, Marie-Pascale Pomey, Nicolas Fernandez

Patient Experience Journal

Hematological cancers represent 10% of cancers diagnosed in Canada. Treatments involve complex care pathways and various modalities as well as the management and monitoring of multiple side effects. There is limited understanding of these pathways from the perspectives of the people living with cancer (PLC) and the healthcare professional (HCP). The aim of this article is to contrast the experiences of PLCs and HCPs in the context of hematological cancer care pathway. Narrative study approach was chosen for this exploratory study. Twenty-one narratives were co-created with PLCs (n = 12) and HCPs (n = 9). A structural and comparative analysis …

Patient Similarity Analysis And Decision Support Dashboards In Cancer Care: Patients' And Other Stakeholders' Perspectives, Karol Jan Czuba Dr, Te Hao Apaapa-Timu Mrs, Rachel B. Owens, Robert Matthew Strother Dr, Ryan P. Radecki Dr

Patient Experience Journal

Patient Similarity Analysis can be used to develop personalised aids for patients and clinicians making complex healthcare decisions, including those encountered in the oncology domain. However, little is known about patients’ views on how insights derived through Patient Similarity Analysis may be incorporated into decision making at the point of care. In this study, we developed a set of Patient Similarity-based dashboard mock-ups and consulted oncology stakeholders in Aotearoa New Zealand regarding acceptability. Aim: To explore oncology stakeholders’ (patients, clinicians, researchers and advocates) perspectives on the acceptability of using Patient Similarity-based decision dashboards to guide decision making. Methods: This is …

Asthma Exacerbation In Pregnancy And The Effects On The Fetus, Jaclyn Vanberkum, Daisy Ramirez, Julia Gonazlez, Haneen Kittaneh

RESP 1102 Intermediate Respiratory Care

Asthma is one of the most common chronic conditions affecting pregnant women and poses notable risks to both maternal and fetal health. Inadequate asthma control during pregnancy is associated with increased complications such as preeclampsia, preterm delivery and low birth weight. As a result, effective asthma management is essential throughout gestation. This paper explores the physiological changes in pregnancy that influence asthma, the potential consequences of uncontrolled symptoms and evidence-based treatment approaches. Current clinical guidelines emphasize the importance of inhaled corticosteroids and bronchodilators while minimizing systemic steroid use. Patient education, regular monitoring and a multidisciplinary approach are key to optimizing …

Sexual And Gender Minority Individuals In Our Community: Policy Recommendations To Address Discrimination-Related Stresses, Emylia N. Terry

Lincy Institute Events

Sexual and gender minority (SGM) individuals face a wide range of mental and physical health challenges, which contribute to higher rates of suicide. SGM individuals encounter distress, discrimination, and in some cases, harmful anti-LGBTQIA+ laws and policies that contribute to additional mental and physical health stress. A web-based survey of 1,034 SGM participants in the United States measured the types and frequency of discrimination occurrences and related distress. The survey considers the variety of interactions between individuals and their relationships, while also measuring the community and societal factors that affect health outcomes for SGM individuals. This research evaluates many variables …

The Antelope, University Of Nebraska At Kearney

The Antelope

No abstract provided.