Digital Commons Network^™

Building Toward A Text-Based Intervention For Parents Of Suicidal Adolescents Seeking Emergency Department Care: A Pilot Randomized Controlled Trial., Ewa Czyz, Inbal Nahum-Shani, Cynthia Ewell Foster, Valerie Micol, Amanda Jiang, Nadia Al-Dajani, Alejandra Arango, Maureen Walton, Victor Hong, Sheikh Iqbal Ahamed, Cheryl King

Computer Science Faculty Research and Publications

Objective: The growing demand for emergency department (ED) care for suicidal ideation and attempts in adolescents calls for effective interventions preventing post-ED recurrence of suicidal crises. Parents are tasked with implementing postdischarge suicide prevention recommendations, often with little support. To address this need, this study examined a parent-facing texting intervention targeting parental engagement in suicide prevention activities to lower youth suicide risk after discharge. Method: A pilot randomized controlled trial was conducted with 120 parents (83.3% mothers) and their adolescents (ages 13–17, 65.8% female, 75.0% White) presenting to an ED with suicide risk concerns. Parents were randomized to a control …

Impact Of Invasive Pine Trees And Their Ectomycorrhizal Fungi Symbionts Upon The Properties And Functions Of Soils In Southern Hemisphere Eucalyptus Forests, Jack T. Baker

Honors Theses

P. radiata trees are invading Southern Hemisphere Eucalyptus forests within New Zealand and southeastern Australia, resulting in a novel codominant forest system. This codominant invasion is unique relative to other pine invasions throughout the Southern Hemisphere. Ectomycorrhizal fungi (EMF) play an important role in all pine invasions and are found within each instance of invasion. The impact of ectomycorrhizal fungi and Pinus trees upon the properties of the soil within Eucalyptus forests is not very well studied nor understood. Our study sought to provide insight into the implications of this invasion upon the soil, and consequently the ecosystem as …

Stereotypic Behaviors And Physiological Indicators Of Stress Occur In Horses With Restricted Durations Of Turnout, Elizabeth E. Rodgers

Department of Animal Science: Dissertations, Theses, and Student Research

The confinement of horses to stalls with limited or no turnout time restricts their natural roaming behaviors, which potentially increases stress and behavioral stereotypies. This study investigated the impact of turnout duration on behavioral and physiological stress indicators in healthy horses. Adult horses (n = 11) were enrolled in a 3 treatment (0-, 15-, and 60-minute turnout/day) Latin square design, including 3 12 d experimental periods over 6 weeks. Horses were acclimated to turnout (24.38 x 64.01m indoor arena) and stalls (2.74 x 4.87m - 3.66 x 3.66m) stalls prior to data collection on day 1. Experienced handlers managed …

Digestibility, Palatability, And Nutrient Composition Of Three Species Of Whole Prey In Three Species Of Snakes, Morgan R. Kienzle

Department of Animal Science: Dissertations, Theses, and Student Research

Snakes in human care often lack diversity in the diet. Rodents account for the majority of meals, while wild snakes are consuming a varied diet composed of multiple different whole prey species. By feeding only one species of prey, the chance of nutrient deficiencies and other health concerns increases. To promote variety in the managed diet, two commercially available whole prey species (mice (Mus musculus) and chicks (Gallus spp.)) and one novel species (Seba’s short-tailed bats (Carollia perspicillata)), were analyzed for their dry matter (DM), organic matter (OM), crude protein (CP), crude fat …

Methane Mitigation And Its Effects On Energy Utilization In Lactating Dairy Cattle, Shan C. Sherwood

Department of Animal Science: Dissertations, Theses, and Student Research

Improved methane (CH₄) mitigation strategies are needed to achieve the greenhouse gas emission goals of the dairy industry. The first experiment was conducted to evaluate the effects of feeding black cumin (Nigella sativa) seed oil and acetate (BCA) on CH₄ production and whole-animal energy utilization. Twelve dry Jersey cows were used in a 2-period crossover design study with 28d periods. The BCA treatment was compared to a control diet with corn oil. Both BCA and corn oil were added to the base diet as a top dress. Results from this study did not show any …

Precision Feeding Methods To Increase Nitrogen And Energy Utilization In Lactating Dairy Cows, Chloe Emily Moss Harris

Department of Animal Science: Dissertations, Theses, and Student Research

The environmental and economic costs of overfeeding N to dairy cattle are a challenge in today’s dairy industry. Two studies were conducted to address new opportunities for precision feeding N, which is a strategy where producers strive to feed cows the precise amount of N and amino acids that meet their individual requirements.

The objective of the first study was to evaluate the effects of supplementing a rumen protected methionine (RPM) product via automatic milking system (AMS) concentrate on milk protein yield in lactating dairy cows. Fifty-one cows were randomly assigned to control (no RPM) or treatment groups. Milk yield …

Comparison Of Random Blood Sugar, Uric Acid, And Cholesterol Levels In Krangkeng Village With Karangjaladri Village, West Java, Indonesia, Rini Hendriani, Aria Aristokrat, Yuni E. Hadisaputri, Iyan Sopyan

Pharmacology and Clinical Pharmacy Research

The prevalence of metabolic diseases has increased over time, especially in Indonesia where 17.5% of the population suffers from metabolic syndrome. Metabolic diseases themselves are related to each other such as diabetes mellitus, gout, and dyslipidemia. One of the causes of metabolic diseases is environmental factors so this research aims to examine whether there was a relationship between metabolic diseases between two villages with different environmental conditions (Krangkeng Village and Karangjaladri Village). Data analysis used IBM SPSS Statistics 25 with random blood glucose, total cholesterol, and uric acid data taken using the Multi-Monitoring System Autocheck 3 in 1. The results …

A Comprehensive Review Of Carbon Sequestration And Its Assessment Techniques Using Remote Sensing And Geospatial Methods, Imen Ben Salem

All Works

Global warming has elevated carbon sequestration as a critical strategy for mitigating climate change, while enhancing sustainability in productivity. Agricultural land use systems contribute substantially to CO2 emissions due to crop residues, shifting cultivation practices, low-biomass crops, land degradation, and deforestation. The significant rise in CO2 emissions over the past thirty years is associated with burning fossil fuels, leading to substantial environmental changes, including global warming. Remote sensing (RS) and Geographic Information Systems (GIS) are advanced geospatial technologies that facilitate the rapid evaluation of terrestrial carbon stock over extensive regions. An integrated RS-GIS approach for carbon stock estimation and precision …

Cytotoxicity And Surface Area Analysis Of Silver Nanoparticles Encapsulated In Liposomes, Pvp, And Bsa: Effects On Caco-2 And U251 Cells, Rita Byrne, Vinayak Sharma, Bilal Javed, Muhammad Zia Ul Haq, Ahmed Barhoum, Furong Tian

Research Outputs: 2025-Present

No abstract provided.

Menstrual Justice After Dobbs, Margaret E. Johnson

All Faculty Scholarship

This Article identifies and analyzes the category of state and private regulation that is invisible and subordinates women and other menstruators in ways that impact their privacy, liberty, and equality. Because this category of regulation is pervasive, bringing it to light is critical for considering how best to curb its harm. This Article considers potential legal strategies to counter such menstruation regulation and argues that Dobbs v. Jackson Women’s Health Organization offers some promise—but more cause for pessimism—regarding the U.S. Constitution’s power to do so. This Article therefore explains how subconstitutional law offers greater potential, while cautioning that political science …

Belowground Response Of C3 And C4 Grass Dominated Plant Communities To Future Larger And Less Frequent Rainfall Events, Zigeng Chen, A. Joshua Leffler

NRM Departmental Data Sets

Data description:
Month: Time of data collection from 2020 to 2022.
Plant community: C3 plant community and C4 plant community.
Treatment: ambient treatment and manipulated treatment.
AMF: Arbuscular Mycorrhizal Fungi concentration (ng C g-1 Soil).
F: Fungi concentration (ng C g-1 Soil).
GP: Gram-Positive bacteria concentration (ng C g-1 Soil).
GN: Gram-Negative bacteria concentration (ng C g-1 Soil).
Actinomycetes: concentration (ng C g-1 Soil).
Saprophytes: concentration (ng C g-1 Soil).
F:B: The ratio of Fungi concentration over sum of Gram-Positive and Gram-Negative bacteria concentration.
GP:GN: The ratio of Gram-Positive bacteria concentration over Gram-Negative bacteria concentration.

File type: zip/application (Contains .xlxs …

Advancing Marine Animal Movement Studies Using An Open Innovation Framework, Jacob Levenson

Graduate Doctoral Dissertations

This dissertation investigates the application of open innovation to migratory marine animal movement studies, addressing critical challenges in understanding, managing and ultimately conserving highly mobile and migratory species (HMMS). The species examined herein, including manta rays, sea turtles, and marine mammals, face threats including habitat disruption and behavioral changes to adapt to anthropogenic stressors. Traditional monitoring techniques, while valuable, are often costly, limited in scale, and protected by proprietary intellectual property, all of which decrease accessibility. Ambitious conservation goals, such as protecting 30% of the ocean by 2030, require more data that are indubitably sharable and thus will need to …

Repair Through Recycling, Emma Murdock, Karl Aspelund

Senior Honors Projects

Repair Through Recycling is an instructional website I developed to encourage people to mend their garments rather than throw them away.I see this as a way to help address the growing issue of textile waste, where millions of garments are discarded each year. Many of these are made from synthetic materials that do not break down, contributing significantly to environmental pollution. This project features step-by-step instructional videos I created to teach the basics of mending, skills that are no longer commonly taught. These tutorials cover foundational techniques such as threading a needle and hand-stitching torn seams. The website also includes …

Assessing Use Of Suicide Prevention And Awareness Training In Rhode Island Public Secondary Schools, Marisa A. Waycuilis

Senior Honors Projects

Suicide has become the second leading cause of death in adolescents in the United States (CDC, 2023). To prevent suicide among school-aged children, the state of Rhode Island enacted the Nathan Bruno and Jason Flatt Act (2021-H5353, 2021-S003) in July of 2021. The legislation requires teachers, students (Grade 6 through 12), and hired school personnel to be annually trained in suicide awareness and prevention. In addition, each public school district must adopt a policy addressing produces relating to suicide prevention, intervention, and postvention. This project aimed to evaluate the level of compliance with the Nathan Bruno and Jason Flatt Act …

Nutrition And Cardiovascular Disease, Sarah Gover, Sarah Gover

Senior Honors Projects

Cardiovascular disease (CVD) remains the leading cause of death globally, with poor dietary habits among its most significant risk factors. While past research has focused on individual nutrients, there is a growing interest in how overall dietary patterns contribute to CVD risk and prevention. This project explores six dietary patterns: vegan, vegetarian, ketogenic, low-fat, intermittent fasting, and Mediterranean. Each diet’s impact on cardiovascular risk factors such as blood pressure, lipid profiles, and inflammation is evaluated, along with their benefits, limitations, and long-term sustainability. Through this investigation, I found that diets rich in fruits, vegetables, whole grains, lean proteins, and healthy …

Single Valued Neutrosophic Hypersoft Set Based On Merec-Moosra Mcdm Methods For Evolution Of Sustainable Strategies For The Circular Supply Chain Based On The Beverage Industry, Alaa Salem, Rayan Hussein, Ahmed Abdelmouty, Mohamed Abouhawwash

Neutrosophic Systems with Applications

Corporate enterprises around the world are facing increasing pressure to operate sustainably due to rising environmental concerns such as climate change, resource scarcity, and ecological degradation. In response, circular supply chain (CSC) practices have emerged as a promising solution, especially within the manufacturing and beverage sectors. CSC focuses on reusing materials, minimizing waste, and creating value from products that have reached the end of their lifecycle. This study investigates the challenges and opportunities of applying circular supply chain management (CSCM) in the beverage industry, which is known for generating significant waste due to high production volumes. The research identifies key …

A Comparison Of Carbon Ions Versus Protons For Integrated Mode Ion Imaging, Mikaël Simard, Ryan Fullarton, Lennart Volz, Christoph Schuy, Daniel G Robertson, Allison Toltz, Colin Baker, Sam Beddar, Christian Graeff, Charles-Antoine Collins Fekete

Faculty, Staff and Student Publications

Background: Incorporating image guidance into ion beam therapy is critical for minimizing beam range uncertainties and realizing the modality's potential. One promising avenue for image guidance is to capture transmission ion radiographs (iRads) before and/or during treatment. iRad image quality is typically maximized using a single-event imaging system, which involves tracking individual ions, albeit the approach is generally not suited to clinical beam settings. An alternative faster and clinically compatible method is integrated mode imaging, where individual pencil beam data is acquired, rather than single ion data. To evaluate the usefulness of transmission ion imaging for image guidance, it is …

Temi: Tissue-Expansion Mass-Spectrometry Imaging, Hua Zhang, Lang Ding, Amy Hu, Xudong Shi, Penghsuan Huang, Haiyan Lu, Paul W Tillberg, Meng C Wang, Lingjun Li

Faculty, Staff and Students Publications

The spatial distribution of diverse biomolecules in multicellular organisms is essential for their physiological functions. High-throughput in situ mapping of biomolecules is crucial for both basic and medical research, and requires high scanning speed, spatial resolution, and chemical sensitivity. Here we developed a tissue-expansion method compatible with matrix-assisted laser desorption/ionization mass-spectrometry imaging (TEMI). TEMI reaches single-cell spatial resolution without sacrificing voxel throughput and enables the profiling of hundreds of biomolecules, including lipids, metabolites, peptides (proteins), and N-glycans. Using TEMI, we mapped the spatial distribution of biomolecules across various mammalian tissues and uncovered metabolic heterogeneity in tumors. TEMI can be easily …

Optimal Delay Time To Initiate Anticoagulation After Ischemic Stroke In Atrial Fibrillation: A Pragmatic, Response-Adaptive Randomized Clinical Trial, Steven J Warach, Lisa A Davis, Patrick Lawrence, Byron Gajewski, Jo Wick, Fred Shi, Ty T Shang, Daiwai M Olson, Sidarrth Prasad, Lee Birnbaum, Jody M Richardson, Sean I Savitz, Mark P Goldberg, Salvador Cruz-Flores, Israel Alba, Jane Anderson, Barbara Kimmel, Chethan P Venkatasubba Rao, Ben King, Adrienne N Dula, Truman J Milling

Faculty, Staff and Students Publications

Importance: Clinical practice guidelines recommend initiation of anticoagulation within 2 weeks after stroke with atrial fibrillation. It is unknown whether there is an optimal starting day within the 14-day period that balances the risks of recurrent embolic events against serious hemorrhagic events.

Objective: To determine if there is an optimal delay time to initiate treatment with a direct oral anticoagulant after atrial fibrillation-related stroke that minimizes the risk of a composite outcome of ischemic or hemorrhagic events.

Design, setting, and participants: This phase 2, pragmatic, response-adaptive randomized clinical trial was conducted between June 2017 and June 2023 at acute care …

Multicenter Food Protein-Induced Enterocolitis Syndrome (Fpies) Data Collection: Leveraging A Redcap Fpies Registry For Improved Clinical Outcomes, Ankona Banerjee, J Andrew Bird, Amy M Scurlock, Pooja Varshney, Elizabeth Brunner, Ankur Bhagwath, Benjamin Daines, Malika Gupta, Tevon Hood, Maria Lee, Michelle Lee, Emily Seminara, Rachel Smith, Gail Tan, Marion Jose Valladares, Hiral Waghela, Duc T Nguyen, Sara Anvari

Faculty, Staff and Students Publications

Background: Food protein-induced enterocolitis syndrome (FPIES) is a non-IgE-mediated food allergy typically presenting in infancy but has also been recognized in adults. FPIES is an allergic emergency due to severe vomiting occurring 1 to 4 hours after ingesting the causative food protein. Since the 2017 FPIES guidelines, no prospective data exist on the prevalence, incidence, and clinical characteristics of FPIES.

Objective: We established a multicenter FPIES registry to systematically collect clinical data and biospecimens on FPIES patients.

Methods: The FPIES registry is a US multicenter REDCap database collecting epidemiologic data to support the evolving FPIES landscape in relation to age …

Evaluating The Test-Negative Design For Covid-19 Vaccine Effectiveness Using Randomized Trial Data: A Secondary Cross-Protocol Analysis Of 5 Randomized Clinical Trials, Leah I B Andrews, M Elizabeth Halloran, Kathleen M Neuzil, Lars Van Der Laan, Yunda Huang, Jessica Andriesen, Mayur Patel, Leigh H Fisher, Holly Janes, Nadine Rouphael, Stephen R Walsh, Deborah A Theodore, Hong-Van Tieu, Magdalena Sobieszczyk, Hana M El Sahly, Lindsey R Baden, Ann R Falsey, Thomas B Campbell, Colleen F Kelley, Catherine Mary Healy, Lilly Immergluck, Benjamin Luft, Ian Hirsch, Guy De Bruyn, Carla Truyers, Frances Priddy, Kelsey M Sumner, Brendan Flannery, Dean Follmann, Peter B Gilbert, Covid-19 Prevention Network (Covpn)

Faculty, Staff and Students Publications

Importance: The test-negative design (TND) has been widely used to assess postmarketing COVID-19 vaccine effectiveness but requires further evaluation for this application.

Objective: To determine whether the TND reliably evaluates vaccine effectiveness against symptomatic COVID-19 using placebo-controlled vaccine efficacy randomized clinical trials (RCTs).

Design, setting, and participants: This secondary cross-protocol analysis constructed TND study datasets from study sites in 16 countries across 5 continents using the blinded phase cohorts of 5 harmonized phase 3 COVID-19 Prevention Network RCTs: COVE (Coronavirus Vaccine Efficacy and Safety), AZD1222, ENSEMBLE, PREVENT-19 (Prefusion Protein Subunit Vaccine Efficacy Novavax Trial COVID-19), and VAT00008. Participants included adults …

Differences In Blood Leukocyte Subpopulations In Schizophrenia: A Systematic Review And Meta-Analysis, Leon Dudeck, Madeleine Nussbaumer, Thomas Nickl-Jockschat, Paul C Guest, Henrik Dobrowolny, Gabriela Meyer-Lotz, Zhongming Zhao, Roland Jacobs, Kolja Schiltz, Brisa S Fernandes, Johann Steiner

Faculty, Staff and Student Publications

Importance: This study aims to provide robust evidence to support or challenge the immune hypothesis of schizophrenia.

Objective: To conduct a meta-analysis of reports on blood leukocyte subpopulations in schizophrenia vs healthy controls, examining disease- and treatment-related differences as well as potential confounders.

Data sources: Systematic database search for English and non-English peer-reviewed articles in PubMed, Web of Science, Scopus, and Cochrane Library databases, with the last search in January 2024.

Study selection: Cross-sectional, case-control, and longitudinal studies comparing leukocyte numbers in patients with schizophrenia and healthy controls. After duplicates were removed, 3691 studies were identified for screening.

Data extraction …

Advancing Understanding And Therapeutic Strategies For Nut Sarcomas: Comprehensive Review Of The Literature And Two Cases, Carlos Torrado, Elise Nassif Haddad, Neeta Somaiah, Pavlos Msaouel, Alexander J Lazar, Sarina A Piha-Paul

Faculty, Staff and Student Publications

Soft tissue sarcomas (STSs) are a group of rare cancers, among which nuclear protein in testis (NUT) sarcomas represent an ultra-rare subset driven by NUTM1 gene fusions. This article presents two unique cases of NUT sarcomas and conducts a comprehensive review of the literature to include an additional 61 cases. Our review reveals that NUT sarcoma exhibits a slightly higher incidence among women (male-to-female ratio of 1:1.03) and tends to manifest at a relatively young age (median age of 40 years). The most prevalent NUT partner genes were the MAD family in 52% of patients (33 of 63 patients, including …

Phase Ii Trial Of Atezolizumab And Bevacizumab For Treatment Of Hpv-Positive Unresectable Or Metastatic Squamous Cell Carcinoma Of The Anal Canal, Van K Morris, Suyu Liu, Kangyu Lin, Haifeng Zhu, Seema Prasad, Armeen Mahvash, Priya Bhosale, Baohua Sun, Edwin R Parra, Ignacio Wistuba, Arjun Peddireddy, James Yao, Julia Mendoza-Perez, Mark Knafl, Scott E Woodman, Cathy Eng, Daniel Halperin

Faculty, Staff and Student Publications

Purpose: Anti-PD-L1 antibodies are associated with responses in < 25% of patients with metastatic human papillomavirus-associated malignancies. VEGF signaling causes immune evasion and immune suppression within the tumor. We evaluated the anti-PD-L1 antibody atezolizumab and anti-VEGF antibody bevacizumab for patients with unresectable, advanced anal cancer.

Patients and methods: For this phase II study, participants with previously treated, immunotherapy-naïve anal cancer received atezolizumab (1,200 mg) and bevacizumab (15 mg/kg) intravenously every 21 days. Responses were evaluated every 9 weeks (RECIST version 1.1). The primary endpoint was the best radiographic response. Median survival was estimated by Kaplan-Meier and compared for selected biomarkers (including paired pre- and on-treatment biopsies) using a log-rank test.

Results: Among 20 participants, the overall response rate was 11% [95% confidence interval (CI): 1.2-32]. Median progression-free survival and overall survival were 4.1 months (95% CI, 2.6-not …

Maternal Cardiometabolic Risk Factors In Pregnancy And Offspring Blood Pressure At Age 2 To 18 Years., Zhongzheng Niu, Ako Adams Ako, Sarah Dee Geiger, Caitlin G. Howe, Wei Perng, Rachana Singh, Margaret R. Karagas, Amy J. Elliott, Andrea Cassidy-Bushrow, Carlos A. Camargo, Keia Sanderson, Cynthia T. Mcevoy, Emily Oken, Dana Dabelea, Tina V. Hartert, Brian S. Carter, Annemarie Stroustrup, Andrea Lampland, Thomas G. O'Connor, Semsa Gogcu, Mark L. Hudak, Lyndsey E. Shorey-Kendrick, Qi Zhao, Yu Ni, Jeffrey Vanwormer, Assiamira Ferrara, Monique Hedderson, Yeyi Zhu, Akram Alshawabkeh, Jose Cordero, Daphne Koinis-Mitchell, Susan Carnell, Carrie V. Breton, Theresa M. Bastain, Shohreh F. Farzan, Echo Cohort Consortium

Manuscripts, Articles, Book Chapters and Other Papers

IMPORTANCE: Higher blood pressure in early life may signal cardiovascular disease over the life course, but determinants of blood pressure in early life are poorly understood.

OBJECTIVE: To examine the association of maternal cardiometabolic risk factors during pregnancy with offspring blood pressure from age 2 to 18 years and explore whether the association is modified by offspring sex and race and ethnicity.

DESIGN, SETTING, AND PARTICIPANTS: This cohort study analyzed data from the Environmental Influences on Child Health Outcomes program between January 1, 1994, and March 31, 2023. Three common maternal cardiometabolic risk factors during pregnancy were examined: prepregnancy obesity, …

Tumour Size Is Associated With Growth Rates Of >0.5 Cm/Year And Delayed Intervention In Small Renal Masses In Patients On Active Surveillance, Maximilian Pallauf, Michael Rezaee, Roy Elias, Tina Wlajnitz, Sean A Fletcher, Joseph Cheaib, Khalid Alkhatib, Peter Chang, Andrew A Wagner, James M Mckiernan, Mohamad E Allaf, Phillip M Pierorazio, Nirmish Singla

Faculty, Staff and Student Publications

Objective: To evaluate the association between tumour size and the growth rate (GR) of small renal masses (SRMs) in patients managed by active surveillance (AS).

Materials and methods: We queried the prospective, multi-institutional Delayed Intervention and Surveillance for Small Renal Masses (DISSRM) registry for patients on AS with an imaging interval of ≥6 months, identifying 456 patients. We tracked tumour size over time; a GR >0.5 cm/year was defined as a GR event. We used multivariable recurrent events and time-to-event Cox regression modelling to evaluate the association between tumour size and GR events (primary outcome) and tumour size and delayed …

Race And Clinical Outcomes In Hormone Receptor-Positive, Her2-Negative, Node-Positive Breast Cancer In The Randomized Rxponder Trial, Yara Abdou, William E Barlow, Julie R Gralow, Funda Meric-Bernstam, Kathy S Albain, Daniel F Hayes, Nancy U Lin, Edith A Perez, Lori J Goldstein, Stephen K L Chia, Sukhbinder Dhesy-Thind, Priya Rastogi, Emilio Alba, Suzette Delaloge, Anne F Schott, Steven Shak, Priyanka Sharma, Danika L Lew, Jieling Miao, Joseph M Unger, Debasish Tripathy, Gabriel N Hortobagyi, Lajos Pusztai, Kevin Kalinsky

Faculty, Staff and Student Publications

Background: The phase III RxPONDER trial has affected treatment for node-positive (1-3), hormone receptor-positive, HER2-negative breast cancer with a 21-gene recurrence score (RS) less than 26. We investigated how these findings apply to different racial and ethnic groups within the trial.

Methods: The trial randomly assigned women to endocrine therapy (ET) or to chemotherapy plus ET. The primary clinical outcome was invasive disease-free survival (IDFS), with distant relapse-free survival (DRFS) as a secondary outcome. Multivariable Cox models were used to evaluate the association between race/ethnicity and survival outcomes, adjusting for clinicopathological characteristics, RS, and treatment.

Results: A total of 4048 …

Precision Proteogenomics Reveals Pan-Cancer Impact Of Germline Variants, Fernanda Martins Rodrigues, Nadezhda V Terekhanova, Kathleen J Imbach, Karl R Clauser, Myvizhi Esai Selvan, Isabel Mendizabal, Yifat Geffen, Yo Akiyama, Myranda Maynard, Tomer M Yaron, Yize Li, Song Cao, Erik P Storrs, Olivia S Gonda, Adrian Gaite-Reguero, Akshay Govindan, Emily A Kawaler, Matthew A Wyczalkowski, Robert J Klein, Berk Turhan, Karsten Krug, D R Mani, Felipe Da Veiga Leprevost, Alexey I Nesvizhskii, Steven A Carr, David Fenyö, Michael A Gillette, Antonio Colaprico, Antonio Iavarone, Ana I Robles, Kuan-Lin Huang, Chandan Kumar-Sinha, François Aguet, Alexander J Lazar, Lewis C Cantley, Urko M Marigorta, Zeynep H Gümüş, Matthew H Bailey, Gad Getz, Eduard Porta-Pardo, Li Ding

Faculty, Staff and Student Publications

We investigate the impact of germline variants on cancer patients' proteomes, encompassing 1,064 individuals across 10 cancer types. We introduced an approach, "precision peptidomics," mapping 337,469 coding germline variants onto peptides from patients' mass spectrometry data, revealing their potential impact on post-translational modifications, protein stability, allele-specific expression, and protein structure by leveraging the relevant protein databases. We identified rare pathogenic and common germline variants in cancer genes potentially affecting proteomic features, including variants altering protein abundance and structure and variants in kinases (ERBB2 and MAP2K2) impacting phosphorylation. Precision peptidome analysis predicted destabilizing events in signal-regulatory protein alpha (SIRPA) and glial …

Maternal Dysbiosis Produces Long-Lasting Behavioral Changes In Offspring, Jacob Hudobenko, Claudia M Di Gesù, Patrick R Mooz, Joseph Petrosino, Nagireddy Putluri, Bhanu P Ganesh, Kristen Rebeles, Frank W Blixt, Venugopal R Venna, Louise D Mccullough

Faculty, Staff and Student Publications

Advanced maternal age (AMA) is defined as a pregnancy in a woman older than 35 years of age. AMA increases the risk for both maternal and neonatal complications, including miscarriage and stillbirth. AMA has also been linked to neurodevelopmental and neuropsychiatric disorders in the offspring. Recent studies have found that age-associated compositional shifts in the gut microbiota contribute to altered microbial metabolism and enhanced inflammation in the host. We investigated the specific contribution of the maternal microbiome on pregnancy outcomes and offspring behavior by recolonizing young female mice with aged female microbiome prior to pregnancy. We discovered that pre-pregnancy colonization …

Pathobiology Of Aortic Aneurysms And Dissections: Synthesis Of Recent Investigations And Evolving Insights, L Maximilian Buja, Bihong Zhao, Deborah Vela, Ana Segura, Navneet Narula

Faculty, Staff and Student Publications

The pathobiology of aortic disease is linked to aortic region: atherosclerosis for abdominal aorta, primary medial degeneration or aortitis for ascending thoracic aorta, and all causes for descending thoracic aorta and thoracoabdominal lesions. The pathogenesis of aortic dissection involves damage of the outer media from impaired perfusion from dysfunctional vasa vasorum, formation of discrete foci of disrupted vascular smooth muscle cell-elastic fiber extension-contractile units, and imbalance of radial sheer stress across the aortic wall, thereby creating an intimal tear and linear dissection. Thoracic aortic aneurysms develop from the chronic progression of medial degeneration coupled with the weakening of the remodeled …