Course Portfolio: Csce 478/878 Introduction To Machine Learning, Hongzhi Guo

UNL Faculty Course Portfolios

This course portfolio was developed for CSCE 478/878: Introduction to Machine Learning, offered by the School of Computing at the University of Nebraska–Lincoln, as part of the Faculty-led Inquiry into Reflective and Scholarly Teaching (FIRST) project. The course provides an introduction to foundational machine learning concepts, models, and programming tools. It enrolls both undergraduate and graduate students from a wide range of academic backgrounds, including computer science, computer engineering, software engineering, biological systems engineering, chemical engineering, business-related fields, etc. Offered in Spring 2025, the course was peer-reviewed to support continuous improvement in teaching. The primary goals of this portfolio are …

Cone Beam Ct Dose Optimisation: A Review And Expert Consensus By The 2022 Estro Physics Workshop Igrt Working Group, Lydia J. Wilson, Andria Hadjipanteli, Daniella E. Østergaard, Evelien Bogaert, Kirstie F. Brown, Rianne Dejong, James Earley, Magali Edouard, Marina Khan, Josh Lindsay, Jessica Van Der Himst, George X. Ding, Tim Wood, Marianne C. Aznar, Nuria Jornet, Georgios Ntentas

Department of Radiation Oncology Faculty Papers

Image guided radiotherapy (IGRT) using kilovoltage cone-beam CT (CBCT) has become an indispensable tool to ensure the geometric accuracy of radiotherapy treatment delivery. Although significant technical advances have been made in reducing imaging dose, the repeated imaging procedures can still accumulate significant dose to healthy tissues. Despite the widespread use, we still lack clear guidance for optimisation and widely accepted frameworks for evaluating the quality and suitability of CBCT imaging protocols. To address this gap, the 2022 European Society for Radiotherapy and Oncology (ESTRO) Physics Workshop focused on image-quality and imaging-dose optimisation for IGRT using CBCT. This publication represents a …

Discovery Of Drug Transporter Inhibitors Tied To Long Noncoding Rna In Resistant Cancer Cells; A Computational Model -In Silico- Study, Mohanad Diab, Amel Hamdi, Feras Al-Obeidat, Wael Hafez, Ivan Cherrez-Ojeda, Muneir Gador, Gowhar Rashid, Sana F. Elkhazin, Mahmad Anwar Ibrahim, Tarek Farag Ismail, Samar Sami Alkafaas

All Works

Chemotherapeutic resistance is a major obstacle to chemotherapeutic failure. Cancer cell resistance involves several mechanisms, including epithelial-to-mesenchymal transition (EMT), signaling pathway bypass, drug efflux activation, and impairment of drug entry. P-glycoproteins (P-gp) are an efflux transporter that pumps chemotherapeutic drugs out of cancer cells, resulting in chemotherapeutic resistance. Several types of long noncoding RNA (lncRNAs) have been identified in resistant cancer cells, including ODRUL, MALAT1, and ANRIL. The high expression level of ODRUL is related to the induction of ATP-binding cassette (ABC) gene expression, resulting in the emergence of doxorubicin resistance in osteosarcoma. lncRNAs are observed to be regulators of …

Low Cd25 In Alk+ Anaplastic Large Cell Lymphoma Is Associated With Older Age, Thrombocytopenia, And Increased Expression Of Surface Cd3 And Cd8, Shuyu E, L Jeffrey Medeiros, Hong Fang, Shaoying Li, Guilin Tang, Sa A Wang, Wei Wang, C Cameron Yin, M James You, Swaminathan P Iyer, Luis Malpica, Lianqun Qiu, Zhenya Tang, Qing Wei, Pei Lin, Jie Xu

Faculty, Staff and Student Publications

Background/objectives: Anaplastic lymphoma kinase (ALK)-positive (+) anaplastic large cell lymphoma (ALCL) is known to express CD25, but its significance has not been well studied.

Methods: In the present study, we identified 54 ALK+ ALCL patients with CD25 results available and investigated the significance of CD25 expression levels.

Results: Forty-two (78%) cases had high CD25 expressions, whereas low CD25 expressions were found in 12 (22%) cases. Compared with ALK+ ALCL patients with CD25-high neoplasms, patients with CD25-low neoplasms were older (median: 40 years vs. 29 years, p = 0.01) and more often had thrombocytopenia (40% vs. 0%, p = 0.02). Between …

No Escape From Microplastics: Contamination Of Reef Manta Ray Feeding Areas In A Remote, Protected Archipelago, Jessica Savage, Joanna Harris, Heather J. Koldewey, Tom B. Letessier, M Rowcliffe, D Morritt

School of Biological and Marine Sciences

Remote islands receive plastic debris from elsewhere, ranging from microplastics (>5 mm) to macroplastics, which can further breakdown into microplastics. The ingestion of microplastics by marine species has been linked to decreased fitness. Reef manta rays, Mobula alfredi, are liable to ingest microplastics due to their filter-feeding strategy and habitat overlap with plastic hotspots. Their population is in decline due to unsustainable fishing pressures and a slow life history, with potential additional demographic pressure from plastic pollution. This study investigates the concentration and characteristics of microplastics in the top 0.5 m of the water column in reef manta rays …

Ecg-Based Biometric Key Generation Using Principal Component Analysis And Machine Learning, Ahmad Abadleh

Iraqi Journal for Computer Science and Mathematics

Biometric authentication techniques are fast becoming imperative methods for secure identifications in a wide range of applications, while most of the traditional systems are easily spoofed or forged. In this paper a new approach of deriving a unique biometric key from an electrocardiogram signal is presented owing to physiological uniqueness of heart activity. In this respect, by focusing on RR intervals extracted from ECG signals, the PCA is applied in order to reduce its dimensionality and then form a compact and distinctive biometric key. Thereafter, a Random Forest classifier was used in evaluating the effectiveness of features, where a high …

Retracted: Robust Security System: A Novel Facial Recognition Optimization Using Coronavirus-Inspired Algorithm And Machine Learning, Saif Mohanad Kadhim, Johnny Koh Siaw Paw, Yaw Chong Tak, Shahad Thamear Abd Al-Latief

Iraqi Journal for Computer Science and Mathematics

Facial recognition has become an invaluable and rapidly advancing technology that plays a crucial role in various daily applications. From identity authentication to video surveillance, mobile payment, and even law enforcement and security measures. Despite the remarkable progress, facial recognition is still a dynamic research field and confronts several challenges. One of the main challenges is the high variability in facial images due to factors like facial expressions, lighting conditions, aging, and the presence of accessories. Additionally, the computational complexity and the time concerns surrounding face recognition systems have raised considerations that need to be addressed. This research presents a …

Retracted: Accurate Electrocardiogram Classification Of Heart Disease Using Deep Learning Network, Hadeel M. Saleh, Sahar Hamad Ahmed, Akeel Sh. Mahmoud

Iraqi Journal for Computer Science and Mathematics

Long short-term memory networks can effectively process complex temporal patterns in electrocardiogram data. These sequential models excel at classifying heart disease from the rich signals captured by electrocardiograms. However, traditional algorithms struggle with the intricate waveforms encoded in each heartbeat. Deeper architectures such as LSTM are better equipped to untangle the subtle variations between healthy sinus rhythms and lethal arrhythmias. In this study, an LSTM model was developed to diagnose disease from the PTB dataset. The network was trained using a fusion of deep learning schemes for sequential data. The model underwent several evaluations, from a confusion matrix mapping predictions …

The Relationships Among Orthorexia Nervosa, Perfectionist Tendencies And Academic Achievement In Nutrition And Dietetics Students, Sophia Grace Owens

Master's Theses

Eating disorders can cause a disturbance in how the health of food is viewed (Cerniglia et al., 2017). If a person has disturbances in their eating behaviors that can cause harm to their health, but the behaviors do not fit into the criteria of a specific eating disorder, they fall into the category of a disordered eating pattern (Academy of Nutrition and Dietetics, 2018). Because of the stress the college environment can cause students, some college students may cling to anything they can control, which may be reflected in their dietary habits. Orthorexia Nervosa (ON), a disordered eating pattern, is …

The Impact Of Growth Hormone-Releasing Hormone Antagonist On Human Adipose-Derived Stem Cells, Jeanne Michelle Dugas

Master's Theses

Obesity is a condition that affects over 40% of American adults and contributes to numerous preventable health issues. This condition is caused by increased adipose tissue, which forms when stem cells transform into adipocytes. Mesenchymal stem cells, including human adipose-derived stem cells (hASC), are multipotent with the ability to differentiate into adipocytes, osteocytes, or chondrocytes. Many factors affect this transformation, including the peptide growth hormone-releasing hormone (GHRH). The main role of GHRH is to trigger the release of growth hormone, but it has also been found to play an important role in adipocyte metabolism. We expect that if the differentiation …

The Antioxidant Potential Of Rosemary Leaf-Derived Nanovesicles, Shani Akila Griffin

Master's Theses

Human dermal fibroblasts are essential for maintaining skin homeostasis. However, exposure to exogenous and endogenous stressors can lead to fibroblast instability, extracellular matrix degradation, and excessive reactive oxygen species (ROS) production. These factors contribute to skin aging and ROS-induced skin disorders leading to hair loss. Adverse effects from synthetic treatments have driven interest in natural alternatives like plant extracts for skin therapy. However, the polyphenols in these treatments require an effective delivery system to ensure their stability and targeted application. Plant derived nanovesicles (PDNVs) are emerging as a promising natural alternative for therapeutic applications. Their biocompatibility, stability, and encapsulated compounds …

Targeting Neuronal Nitric Oxide Synthase (Nnos) As A Novel Approach To Enhancing The Anti-Melanoma Activity Of Immune Checkpoint Inhibitors, Anika R. Patel, Shirley Tong, Kate Alison Lozada, Amardeep Awasthi, Richard B. Silverman, Jennifer Totonchy, Sun Yang

Pharmacy Faculty Articles and Research

Background and Objectives: Neuronal nitric oxide synthase (nNOS) overexpressed in melanoma plays a critical role in disease progression. Our previous studies demonstrated that nNOS inhibitors exhibited potent anti-melanoma activity and regulated PD-L1 expressions in the presence of interferon-gamma (IFN-γ). However, the role of nNOS in the melanoma immune response has not been well defined. Methods: Changes in gene expression profiles after nNOS inhibitor treatment were determined by transcriptomic analysis. A melanoma mouse model was used to determine the effects of nNOS inhibition on peripheral T cells and the in vivo anti-tumor activity of combining nNOS inhibitors with immune …

Parent’S Health Literacy And Stress Level In The Inpatient Pediatric Setting, Tina C. Smith

Dissertations

Purpose: This study examined the relationship between parent health literacy and stress levels during their child’s inpatient hospitalization.

Background: In 2019, over five million pediatric hospitalizations occurred in the United States. Parents are central to their child’s care, but stress and sociodemographic factors may hinder their ability to understand and apply health information. This study explored how stress and other variables impact parent health literacy during hospitalization.

Methods: A cross-sectional design included a demographic survey, the Perceived Stress Scale (PSS-10), and the Newest Vital Sign (NVS). Bivariate analyses (Chi-square, t-tests) and logistic regression were used to assess …

Studying The Effect Of Some Additives To The Borosilicate Glass On The Neutron Shielding Properties, Saddam Jamel Abd-Noor, Ahmed Fadhil Mkhaiber

Baghdad Science Journal

The development of radiation shielding material is important since radioactive sources are used in industry, medicine, and agriculture. As a result, more research and development has been put into looking into different glass systems based on their unique qualities for protecting against neutron radiation. This study focuses on investigating glass-based materials for neutron shielding purposes. This investigation delves into the neutron shielding properties of a mixture comprising Sodium Aluminum borosilicate glass (SiB₂Na₂Al₂O₉)_X, with added reinforcement materials (SiC)_100-X, (TiB₂)_100-X, and (BiClO)_100-X (X = 95, …

Improving Social Drivers Of Health Screening In An Inpatient Setting For Sdoh Data, John P. Lussier

Doctor of Nursing Practice Final Manuscripts

Abstract

Purpose

Title of the Project: Improving Social Drivers of Health Screening in an Inpatient Setting for SDoH Data

Purpose: This evidence-based practice project aimed to increase social drivers of health (SDoH) screening compliance by redesigning the workflow to distribute responsibility between nursing and case management, ultimately improving identification and referral of patients with supportive service needs.

Background: Screening for SDoH needs facilitates the provision of appropriate supportive services. The existing workflow required nurses to conduct initial screening in five domains (Housing Stability, Utility Difficulties, Food Insecurity, Interpersonal Safety, and Transportation Needs), with positive responses triggering additional investigative questions. These …

Crisis Without Cops: Trauma-Informed Mental Health Care For Bipoc Communities, Amanda Carson

Doctor of Nursing Practice Final Manuscripts

This policy paper advocates for a structural transformation in mental health crisis response, moving beyond police-led interventions toward trauma-informed, community-rooted models grounded in public health and equity. Drawing on Critical Race Theory (CRT), neuroscience, and program evaluations of models like CAHOOTS, 988, Denver’s STAR, and Durham’s HEART, it examines how systemic racism, institutional mistrust, and implicit bias contribute to disproportionate harm for BIPOC individuals. The paper highlights the effectiveness of peer-led, culturally responsive alternatives that reduce force, hospitalization, and disengagement from care. Using Kingdon’s Multiple Streams Framework, it proposes actionable, scalable policy strategies supported by recent federal momentum, including the …

Implementation Of One Key Question® Screening Tool To Increase Reproductive Life Planning At A Community Health Clinic, Laura D. Adams

Doctor of Nursing Practice Final Manuscripts

Introduction: This evidence-based practice project implemented and evaluated the One Key Question® (OKQ) screening tool to improve pregnancy intention screening and reproductive health counseling in primary care. The goal was to better identify reproductive health needs among women of reproductive age and enhance provider engagement in preconception and contraceptive counseling.

Background: Nearly half of all pregnancies in the U.S. are unintended, and many women do not receive timely reproductive health counseling. Despite national recommendations, pregnancy intention screening is often missed in primary care. Early identification of reproductive goals supports better outcomes through tailored education, contraception, or preconception care. OKQ is …

Increase Knowledge And Competency Of Point Of Care Ultrasound (Pocus) Among Emergency Nurse Practitioner Students Incorporating Web-Based Videos And Clinical Benchmarks., Andrew N. Walsh

Doctor of Nursing Practice Final Manuscripts

Background: Point of care ultrasound (POCUS) is a critical skill in Emergency Medicine (EM), and Emergency Nurse Practitioner (ENP) students are increasingly expected to demonstrate proficiency. ENP students often face limited opportunities for hands-on practice compared to EM residents. Research suggests that the didactic component of POCUS training delivered through e-learning is as effective as in-person instruction. The American College of Emergency Physicians (ACEP) supports the flipped classroom model, which maximizes simulation time and focuses on psychomotor skills and clinical application, allowing didactic portions to be delivered online. Additionally, ACEP recommends a benchmark of at least 25 POCUS examinations to …

Utilizing A Clinical Resource Hub To Improve Access And Workflow For Retinopathy Screenings In The Veteran Population, Erin Kelly Pope

Doctor of Nursing Practice Final Manuscripts

Abstract

Utilizing a Clinical Resource Hub to Improve Access and Workflow for Retinal Screenings in the Veteran Population

Erin K. Pope, MSN, RN, AGCNS-BC, AMB-BC

Scot Nolan, DNP, RN, CNS, PHN, CCRN, CNRN, SCRN, FCNS

Background: Diabetic retinopathy (DR), a progressive complication of diabetes mellitus (DM), is the leading cause of blindness among working-age adults. As DR can remain asymptomatic until advanced stages, annual screenings are critical for early detection and management. Teleretinal imaging is an evidence-based method for DR screening, offering cost efficiency and reduced demand on ophthalmology clinics. At the Veterans Administration’s (VA) Loma Linda Healthcare System …

Control Of Alveolar Bone Development, Homeostasis, And Socket Healing By Salt-Inducible Kinases, Nicha Tokavanich, Byron Chan, Katelyn Strauss, Christian D Castro Andrade, Yuki Arai, Mizuki Nagata, Marc Foretz, Daniel J Brooks, Noriaki Ono, Wanida Ono, Marc N Wein

Faculty, Staff and Student Publications

Alveolar bone supports and anchors teeth. The parathyroid hormone-related protein (PTHrP) pathway plays a key role in alveolar bone biology. Salt-inducible kinases (SIKs) are important downstream regulators of PTH/PTHrP signaling in the appendicular skeleton, where SIK inhibition increases bone formation and trabecular bone mass. However, the function of these kinases in alveolar bone remains unknown. Here, we report a critical role for SIK2/SIK3 in alveolar bone development, homeostasis, and socket healing after tooth extraction. Inducible SIK2/SIK3 (Ubq-creERt;Sik2f/f;Sik3f/f) deletion led to dramatic alveolar bone defects without changes in tooth eruption. Ablating these kinases impairs alveolar bone formation due to disrupted osteoblast …

Thsd1 Is A Multifaceted Regulator In Health And Disease, Mengjun Dai, Kuizhi Qu, Sophie Liu, Zhen Xu, Yan-Ning Rui

Faculty, Staff and Student Publications

Thrombospondin Type 1 Domain-Containing Protein 1 (THSD1) is a transmembrane protein increasingly recognized for its critical roles in vascular biology and disease pathogenesis. Initially identified as a marker of hematopoietic stem and endothelial cells during embryogenesis, THSD1 has since been implicated in a wide spectrum of physiological and pathological processes. This paper consolidates current knowledge on THSD1, with a focus on its roles in vascular integrity, perinatal disorders, and tumorigenesis. In vascular systems, THSD1 promotes focal adhesion assembly and suppresses autophagy-mediated adhesion turnover, thereby stabilizing endothelial attachment and maintaining barrier function. Genetic and functional studies support its protective role against …

Photocatalytic Degradation Of Methylene Blue Dye Using Zinc Oxide Nanoparticles Prepared By Green Synthesized, Anwar Ali Baqer, Nadia Jasim Ghdeeb, Nedal Ali Hussain

Baghdad Science Journal

This study describes the environmentally friendly synthesis of zinc oxide nanoparticles (ZnO-NPs) using cinnamon extract, bay leaf extract, and chemical techniques. Due to its cost-effectiveness and avoidance of harmful ingredients, the green synthesis strategy for producing nanoparticles has significant advantages over physical and chemical procedures. The XRD data demonstrated the production of a hexagonal wurtzite structure, while the SEM investigations demonstrated a spherical shape and average size (21.49, 25.26) nm for ZnO NPs synthesized by cinnamon extract, bay leaf extract, and chemical techniques, respectively. The synthesized ZnO NPs demonstrate noteworthy photocatalytic efficacy in the breakdown of methylene blue dye under …

Prevalence, Experience, And Awareness Of Substandard And Falsified Medicines Among The Public And Healthcare Professionals In Jordan., Maysa Falah, Eman Daar, Daniel Zahra, Michael Dillon

Peninsula Medical School

INTRODUCTION: This study aimed to assess the awareness, experiences and perspectives on substandard and falsified (SF) medicines among the general public and healthcare professionals in Jordan. SF medicines pose a global public health concern, yet data on their prevalence and associated risks in Jordan remain limited.

METHODS: A cross-sectional study was conducted between January and June 2023 using a convergent mixed-methods approach. Quantitative data were collected through structured surveys administered to 209 members of the public and 136 healthcare professionals (pharmacists and clinicians) recruited via convenience sampling across Jordan's 12 governorates. Surveys were conducted in English and Arabic. Qualitative data …

Redefining The Photic Zone: Beyond The Autotroph-Centric View Of Light In The Ocean, Thomas Davies, Tim Smyth

School of Biological and Marine Sciences

Traditional measures of the photic zone have remained focused on autotrophs, limiting understanding of how changing marine lightscapes impact heterotrophs that use light as a resource or an environmental cue. We propose a new photic zone definition that encompasses all biological processes influenced by celestial light, and a new measure of photic zone depth, the minimum light intensity that elicits biological responses. This approach allows photic zone measures to be inclusive of all marine photobiology driven by sunlight, moonlight, or starlight, and enables urgently needed exploration of the nature, extent and ecological implications of changing marine lightscapes.

Diagnostic Significance Of Neutrophil-Lymphocyte Ratio (Nlr) In Dogs With Chronic Enteropathy: A Meta-Analytical Study, Mohamed Marzok, Mahmoud Kandeel, Mohamed Tharwat, Sabry El-Khodery

The Thai Journal of Veterinary Medicine

This meta-analysis aimed to determine the diagnostic significance of the neutrophil-to-lymphocyte ratio (NLR) in dogs with chronic enteropathy (CE). This meta-analysis was constructed according to the PRISMA statement guidelines. The Web of Science, Sage, EBESCO, Ovid, Scopus, and Google Scholar databases were searched. Standardized mean difference (SMD) and odds ratio (OR) were calculated. Heterogenicity and publication bias were evaluated in this study. Five studies were found to be eligible for the assessment of the diagnostic significance of the NLR in dogs with CE. In total, 570 dogs (263 with CE and 307 healthy controls) were included in this study. NLR …

Full Issue

Intuition: The BYU Undergraduate Journal of Psychology

No abstract provided.

Jewish Contributions To The Anti-Apartheid Movement, Ashley Davis

Intuition: The BYU Undergraduate Journal of Psychology

In his autobiography Long Walk to Freedom, Nelson Mandela (1995) wrote, "I have foundJews to be more broad-minded than most Whites on the issues of race and politics, perhaps because they themselves have historically been victims of prejudice" (p. 91). The centuries of persecution faced by Jews engrained into J ewish teachings and culture a strong sense of morality and pushed them towards social and political activism. In South Africa, while White Jews were considered a part of the privileged minority, they faced discrimination and blatant anti-Semitism. Their privileged position as Whites and simultaneous ethnic status as 'lesser' than …

Does Lifetime Stress Influence Chemotherapy Symptoms In Women From Different Racial And Ethnic Groups?, Jemmie Hoang

Sigma Foundation for Nursing Research Grant Reports

We hypothesize women with cancer who identify as a racial and/or ethnic minority will endorse a multitude of lifetime stressors contributing to high symptom(s) severity and burden. This study will be among the first studies to comprehensively describe cumulative life stressors, and its potential influence on cancer symptom burden among racial and/or ethnic minority women with cancer who are receiving chemotherapy. Our study will provide further evidence of the importance of screening for life stressor events that may impact chemotherapy symptom experience.

Nuclear Magnetic Resonance Dynamics Of Pyrazole-Litfsi Eutectic Solvents As Promising Electrolytes, Emilia Pelegano-Titmuss, Giselle De Araujo Lima E Souza, Muhammad Zulqarnain, Ramez Elgammal, Thomas Zawodzinski, Steven Greenbaum

Undergraduate Research

Deep Eutectic Solvents (DESs) have emerged as promising candidates to replace conventional organic solvents in various technological applications due to their low vapor pressure, non-flammability, and ease of preparation at low costs. In particular, Type IV DESs, which are composed of metal salts and hydrogen bond donors, are possible replacements for lithium-ion battery electrolytes due to their potential of having high lithium transference numbers. In this study, we investigated solvents of Pyrazole and LiTFSI at varying molar ratios using Fast Field Cycling (FFC) NMR Relaxometry. Notably, the 1:2 LiTFSI: Pyrazole sample shows distinct behavior, exhibiting enhanced relaxation rates for ^{1 …}

Characterization Of Sars-Cov-2 Replication And Transcription Complexes Via Structural And Evolutionary Approaches, Amelie Ghirardo, Ben Shabatian, Avishai Aghelian, Kyle Tau, Eleonora Gianti

Undergraduate Research

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) caused around 700M cases and over 7M COVID-19-related deaths recorded worldwide (World Health Organization, March 2025). Aiming to effectively combat this and other disease-causing Coronaviruses (CoV), unprecedented research efforts led to the development of new vaccines and antiviral therapies. Due to emergence of variants of concern (VOCs) with increased transmissibility, immune evasion from vaccination, and potential to resist the available treatments, SARS-CoV-2 continues to represent a major threat to global health. Hence, there is a pressing need to discover new antivirals with broad-spectrum efficacy against multiple SARS-CoV-2 variants and related CoVs. This project …