Digital Commons Network^™

Barriers To And Facilitators Of Sustaining A Systemic Lupus Erythematosus (Sle) Patient Decision Aid In Regular Rheumatology Outpatient Care In The Usa, Erin E Blanchard, Allyson G Hall, Ezra Gore, Parvaneh Yaghoubi Jami, Aizhan Karabukayeva, Larry R Hearld, Shelby Gontarz, Jasvinder A Singh

Faculty, Staff and Students Publications

Objective: This study investigates the barriers to and facilitators of sustaining a decision aid (DA) tool for patients with SLE in routine rheumatology outpatient care across the USA. The DA was initially developed for assisting patients with SLE in making informed medication choices by providing personalized information on their treatment process.

Methods: We conducted semi-structured interviews with clinicians, administrators, and information technology (IT) professionals from 15 geographically diverse rheumatology clinics that participated in a large-scale DA implementation trial. Interviews were transcribed and analysed using NVivo, with thematic coding to identify key factors influencing DA sustainability.

Results: The analysis identified several …

Norovirus Replication, Host Interactions And Vaccine Advances, B V Venkataram Prasad, Robert L Atmar, Sasirekha Ramani, Timothy Palzkill, Yongcheng Song, Sue E Crawford, Mary K Estes

Faculty, Staff and Students Publications

Human noroviruses (HuNoVs) are the leading cause of acute gastroenteritis worldwide in all age groups and cause significant disease and economic burden globally. To date, no approved vaccines or antiviral therapies are available to treat or prevent HuNoV illness. Several candidate vaccines are in clinical trials, although potential barriers to successful development must be overcome. Recently, significant advances have been made in understanding HuNoV biology owing to breakthroughs in virus cultivation using human intestinal tissue-derived organoid (or enteroid) cultures, advances in structural biology technology combined with epitope mapping and increased metagenomic sequencing. New and unexpected strain-specific differences in pandemic versus …

Dermatologic Fungal Neglected Tropical Diseases-Part I Epidemiology And Clinical Features, Kaya L Curtis, Jeremy A W Gold, Jana M Ritter, Theodore Rosen, Daniel Wagner C L Santos, Dallas J Smith, Shari R Lipner

Faculty, Staff and Students Publications

In this part 1 of a 2-part continuing medical education series, the epidemiology, clinical features, and diagnostic methods for fungal skin neglected tropical diseases (NTDs), which include eumycetoma, chromoblastomycosis, paracoccidioidomycosis, sporotrichosis, emergomycosis, talaromycosis, and lobomycosis, are reviewed. These infections, several of which are officially designated as NTDs by the World Health Organization, cause substantial morbidity and stigma worldwide and are receiving increased attention due to the potential for climate change-related geographic expansion. Domestic incidence may be increasing in the setting of global travel and immunosuppression. United States dermatologists may play a central role in early detection and initiation of appropriate …

The Efficacy Of Complementary And Alternative Medicines Utilized In Cosmetic And Surgical Dermatology: A Comprehensive Review, Promise Ufomadu, Bartley Joseph Gill, Theodore Rosen, Ikue Shmizu, Ida Orengo

Faculty, Staff and Students Publications

Background: Lately, there has been a growing demand for the utilization of complementary and alternative medicines (CAMs) with dermatological applications. This is true despite limited RCT-level studies on such agents. This presents a barrier for dermatologists and fellow clinicians in counseling patients who may be using or are tempted to use these CAM modalities. This review highlights CAM agents used by patients for applications in cosmetic and surgical dermatology, exploring their efficacy and toxicity profiles.

Methods: A comprehensive review was conducted on the effectiveness of several CAMs utilized in cosmetic and surgical dermatology by patients. A literature search was performed …

Measles, Mumps, Rubella Immunization And The Resurgence Of Measles In America, Peter J Hotez

Faculty, Staff and Students Publications

No abstract provided.

Targeting S1pr2 In Sepsis, One Fragmented Mitochondrion At A Time, Chao He, Jennifer L Larson-Casey

Faculty, Staff and Students Publications

No abstract provided.

Airway Immune Signatures In Severe And Fatal Infection With Covid-19, Naresh Doni Jayavelu, Jing Jing Qi, Slim Fourati, Farrah Kheradmand, Charles R Langelier, Lauren I R Ehrlich, Joann Diray-Arce, Annmarie Hoch, Monica Kraft, Patrice M Becker, Matthew C Altman, Ruth R Montgomery

Faculty, Staff and Students Publications

No abstract provided.

Parp Inhibitor Response Is Enhanced In Prostate Cancer When Xrcc1 Expression Is Reduced, Kaveri Goel, Vani Venkatappa, Kimiko L Krieger, Dongquan Chen, Arun Sreekumar, Natalie R Gassman

Faculty, Staff and Students Publications

Prostate cancer (PCa) is the second most common cancer worldwide and the fifth leading cause of cancer-related deaths among men. The emergence of metastatic castration-resistant prostate cancer (mCRPC) after androgen deprivation therapy (ADT) exemplifies the complex disease management for PCa. PARP inhibitors (PARPis) are being tested to treat mCRPC in tumors with defective homologous recombination repair (HRR) to address this complexity. However, increasing resistance towards PARPi in HRR-deficient patients and the low percentage of HRR-defective mCRPC patients requires the identification of new genes whose deficiency can be exploited for PARPi treatment. XRCC1 is a DNA repair protein critical in the …

Stress, Employment Changes, And Psychological Distress Among Caregivers Of Patients With Head And Neck Cancer, Lama Abdurrahman, Vlad C Sandulache, Cielito Reyes-Gibby, Erich M Sturgis, Pavan Jhaveri, Hoda Badr

Faculty, Staff and Students Publications

Importance: Patients undergoing external beam radiation therapy (EBRT) for head and neck cancer (HNC) often experience adverse effects that require substantial caregiving. The burdens of caregiving can impact caregiver employment and mental health over time, yet this topic remains underexplored.

Objective: To examine the associations between caregiving for patients with HNC who undergo EBRT and caregiver stress, employment status, and psychological distress.

Design, setting, and participants: This was a secondary analysis of data from a longitudinal survey study that surveyed caregivers at baseline (ie, at initiation of EBRT) and at 4-month and 12-month follow-ups. The study was conducted at 2 …

Interactions Between Adgrf1 (Gpr110) And Extracellular Matrix Proteins Govern Its Effects On Tumorigenesis In Her2-Positive Breast Cancer, Noor Mazin Abdulkareem, Raksha Bhat, Micah Castillo, Sung Yun Jung, Suhas Vasaikar, Sarmistha Nanda, Alexis Ruiz, Martin Shea, Wangjia Cao, Jamunarani Veeraraghavan, Hee-Yong Kim, Tasneem Bawa-Khalfe, Tahir Hussain, Xinli Liu, Preethi Gunaratne, Rachel Schiff, Meghana V Trivedi

Faculty, Staff and Students Publications

Background and purpose: We and others have previously shown that ADGRF1, an adhesion G protein-coupled receptor, is overexpressed and associated with poor survival in many cancers, including human epidermal growth factor receptor-2 (HER2) breast cancer (BC). Also, we have reported the tumour-promoting function of ADGRF1 using preclinical models of HER2+ BC. In this study, we investigated the effect of ADGRF1 overexpression in an orthotopic in vivo model as well as downstream signalling of ADGRF1 in HER2+ BC.

Experimental approach: We utilized a doxycycline (Dox)-induced ADGRF1 overexpression system in HER2+ BC cell lines and performed various in vitro and in vivo …

Biomolecular Condensates In Immune Cell Fate, Srikanth Kodali, Caroline M Sands, Lei Guo, Yun Huang, Bruno Di Stefano

Faculty, Staff and Students Publications

Fate decisions during immune cell development require temporally precise changes in gene expression. Evidence suggests that the dynamic modulation of these changes is associated with the formation of diverse, membrane-less nucleoprotein assemblies that are termed biomolecular condensates. These condensates are thought to orchestrate fate-determining transcriptional and post-transcriptional processes by locally and transiently concentrating DNA or RNA molecules alongside their regulatory proteins. Findings have established a link between condensate formation and the gene regulatory networks that ensure the proper development of immune cells. Conversely, condensate dysregulation has been linked to impaired immune cell fates, including ageing and malignant transformation. This Review …

The Frequency, Type, And Function Of Visual Displays In Upper Elementary Standardized Science Tests, Daibao Guo, Katherine Landau Wright, Lianne Josbacher, Eun Hye Son

Boise State University Publications and Presentations

Limited research has explored the use of visual displays (ViDis) in science tests, making it challenging to know how these tests align with classroom instruction and what skills students need to be successful on these tests. Therefore, the current study aims to describe the use of ViDis in upper elementary grade standardized science tests. We quantified the frequency, types, and functions of ViDis in science tests in 23 states and Washington, DC. Findings show that in the 741 test items examined, 74.5% included ViDis. Tables, diagrams, and images are the most common ViDis. Importantly, 42.1% of the ViDis in the …

Light & Faith: June 2025, Taylor University

Light & Faith

No abstract provided.

A Concise Formalization Of Partial Falsifiability, Water Logic, And Neither Nor Logic With Neutrosophic Logic, Takaaki Fujita, Florentin Smarandache, Victor Christianto

Neutrosophic Sets and Systems

No abstract provided.

Planning Negative Emissions Technologies Portfolios Under Neutrosophic Environment,, John Frederick D. Tapia, Maria Victoria Migo-Sumagang

Neutrosophic Sets and Systems

No abstract provided.

Bridging The Gap: Exploring The Intersection Of Formal Mental Health Services And Informal Social Supports In Bipoc Communities, Patrice D. Patton-Campbell

Dissertations

Despite growing awareness of mental health disparities, BIPOC (Black, Indigenous, and People of Color) communities continue to face significant barriers in accessing culturally responsive mental health care. This dissertation explores the intersection between formal mental health services and informal social supports such as family, religious institutions, and community networks to understand which systems are more trusted, accessible, and effective for BIPOC individuals. Grounded in Urban Liberation Psychology and guided by decolonial and culturally responsive care frameworks, this qualitative study draws from focus groups and interviews with 33 participants, including both community members and service providers from the Chicagoland area and …

Narratives Of Jewish American Public School Educators Amid Rising Antisemitism Post October 7, 2023, Cassandra Schwartz

Dissertations

This study investigated how Jewish American public school educators are responding to rising antisemitism post-October 7, 2023. While research exists on global antisemitism, the experiences of Jewish educators within the unique context of American public schools represent a significant and under-explored gap in academic literature. A qualitative narrative research approach, grounded in critical theory, was employed. Data were collected through semi-structured interviews with eight Jewish American public school educators and analyzed thematically. The findings revealed participants’ experiences of a heightened sense of fear and silence from colleagues and institutions, leading to feelings of isolation and being unsupported. Critically, this study …

Collective Analysis, Sydney L. Reichin, Angie Benda, James C. Peters, Joel S. Elson, Samuel Hunter

Reports, Projects, and Research

This report serves as Deliverable 7: Collective Analysis, as tasked by the Department of Homeland Security (DHS). The primary goal of this effort was to review literature (both academic and practitioner-based) related to threats found in K-12 schools, and to validate findings from the literature with interviews with subject matter experts (SMEs). Interviews discussed threats and vulnerabilities SMEs face along with their needs for future risk assessments. This review provides insights within and across interviews from SMEs and resource coding, identifying common and emerging themes that schools experience. The findings will inform the development of a comprehensive K-12 risk assessment …

Diabetes-Related Distress Over Time And Its Associations With Glucose Levels In School-Aged Children., Susana R. Patton, Nicole Kahhan, Amy Milkes, Ryan J. Mcdonough, Matthew Benson, Mark A. Clements, Jessica S. Pierce

Manuscripts, Articles, Book Chapters and Other Papers

INTRODUCTION: In a cohort of families of school-age children (8-12.99 years old) with type 1 diabetes, we examined the stability of parent and child diabetes-related distress (DRD) over 6 months and the associations between parent and child DRD and child glycated hemoglobin (HbA1c) over time.

RESEARCH DESIGN AND METHODS: We recruited families from two large pediatric hospital systems in the USA and used validated measures of parent (Parent Problem Areas in Diabetes-Child, PPAID-C) and child (Problem Areas in Diabetes-Child, PAID-C) DRD and children's HbA1c. We collected data at baseline and 6 months. We calculated minimal clinically important differences in PPAID-C …

Changes In The Fxr-Cistrome And Alterations In Bile Acid Physiology In Wilson Disease, Clavia Ruth Wooton-Kee, Hari K Yalamanchili, Islam Mohamed, Manal Hassan, Kenneth D R Setchell, Monica Narvaez Rivas, Ayse K Coskun, Vasanta Putluri, Nagireddy Putluri, Prasun Jalal, Michael L Schilsky, David D Moore

Children’s Nutrition Research Center Staff Publications

Background: Wilson disease (WD) is an autosomal recessive disorder that results in excessive hepatic copper, causing hepatic steatosis, inflammation, fibrosis, cirrhosis, and liver failure. Previous studies have revealed dysregulation of many farnesoid X receptor (FXR) metabolic target genes in WD, including the bile salt exporter pump, the major determinant of bile flow.

Methods: We tested the hypothesis that the FXR-cistrome is decreased in Atp7b-/- mice in accord with dysregulated bile acid homeostasis.

Results: FXR binding within Atp7b-/- mouse livers displayed surprising complexity: FXR binding was increased in distal intergenic regions but decreased in promoter regions in Atp7b-/- versus wild-type mice. …

Bile Acid Regulation Of Xenobiotic Nuclear Receptors On The Expressions Of Orosomucoids In The Liver, Ji Ho Suh, Inyoung Cheon, Hyun-Jung Jung, Sung Ho Lee, Mi Jeong Heo, Matthew Deberge, Clavia Ruth Wooton-Kee, Kang Ho Kim

Children’s Nutrition Research Center Staff Publications

The constitutive androstane receptor (CAR) and pregnane X receptor (PXR) are xenobiotic nuclear receptors activated by various xenobiotics, drugs, hormones, and bile acids (BAs). Upon activation, these nuclear receptors play critical roles in regulating systemic energy homeostasis. However, precise mechanisms through which CAR and PXR influence systemic metabolism remain incompletely understood. Here, we investigated the impact of CAR and PXR on the liver-secreted hormone (i.e., hepatokine) expressions in response to BA stress such as cholic acid (CA) feeding. Our analysis revealed that several BA-activated genes, including the well-known CAR/PXR target, aldo-keto reductase family 1, member B7 (Akr1b7 …

Studies On The Effects Of Cap Management On The Oxidation–Reduction Potential, Phenolic Composition, And Sensory Properties Of Red Wines, Dallas J. Parnigoni

Master's Theses

Cap management during alcoholic fermentation of red wines plays a critical role in modulating the phenolic and volatile extraction from grape solids, influencing the homogenization of chemical and temperature gradients, while imparting oxygen to the must. Different cap management alternatives are also thought to influence the evolution of the oxidation-reduction potential (ORP). It is critical to understand how different cap management protocols affect these variables to design a cap management protocol tailored to wine style and varietal. This thesis investigated the effects common commercially applied cap management protocols, as well as the efficacy of novel, automated gas mixing protocols as …

Impact Of Seed Moisture And Temperature On Hemp Seed Germination, Paul Cockson, Andrea Webb, Natalia Martinez-Ochoa, Lindsey Moffitt, Robert Pearce, Manohar Chakrabarti

School of Integrative Biological & Chemical Sciences Faculty Publications

Germination rates of commercial lots of hemp have been highly variable, resulting in poor stand establishment. Germination rates in some seed lots have decreased by 50% after only 1 year of storage. The objective of this trial was to investigate the impact of seed storage conditions on seed germination over time. Industrial hemp (IH) seeds (cv. NWG2730) were harvested from the field. The seeds were cleaned, sorted, and dried to specific moisture contents (MC) 6%, 8%, 10%, and 14%. Seeds were subdivided, placed in hermetically sealed packets, and stored at temperatures of −20°C, 4°C, 10°C, or 21°C for 3, 6, …

Scitechatorium, Olivia Lafferty, Yvonne Brien Miller, Colton Swinth, Savannah Pinheiro, Gage Heinze

Mechanical Engineering

Bellevue Santa-Fe Charter School (Bellevue) is a K6th grade public charter elementary school in Avila Beach, California. The primary focus at Bellevue is fostering unique learning experiences, empowering students through project-based learning, and engaging students in creative endeavors. Following these themes, the school has allocated space and funding for an on-campus science and technology museum known as the SciTechatorium. The museum is currently open during students’ lunch period, providing interactive displays on concepts in human biology, nature and wildlife, physics, and electronics. Bellevue’s K-6th grade science teacher, Christian Strauli, and Bellevue parent volunteers are primarily responsible for the museum’s upkeep …

A Digital Dive: Redesigning The Cabrillo High School Aquarium Website, Jacob V. Cacho

Graphic Communication

Tucked away on the Central Coast in Lompoc, you’ll find the Cabrillo High School (CHS) Aquarium. Started in 1986, the CHS Aquarium is the only high school aquarium of its kind in the nation run entirely by high school students. This 10,000+ square foot aquarium serves an underserved community at a Title I school, where students manage all aspects of animal care, nutrition, breeding, educational curriculum development, and visitor tours.

This program is truly one-of-a-kind and deserves the spotlight for just how unique it is. As a CHS graduate, I felt the current website lacked in many areas and could …

Surface Temperature Analysis Report: Kellogg Creek Restoration & Community Enhancement Project, Dalton Palin

University Honors Theses

Kellogg Creek is located in the Kellogg-Mt Scott watershed which flows through downtown Milwaukie, Oregon into the Willamette River. At the confluence of Kellogg Creek and the Willamette River is the Kellogg Dam. This dam impedes salmon, steelhead, and lamprey movement up Kellogg Creek, which is known historically as a salmon and steelhead rearing and migrating habitat. A plan to remove Kellogg Dam and restore 14 acres of Kellogg Creek is in progress by North Clackamas Watersheds Council (NCWC) and partners. Water temperature studies in Kellogg Creek have been conducted for the past several years, this report analyzed thermal surface …

Not Just An Ad: Exploring Exposure, Persuasion Knowledge, And Health Misinformation On Social Media, Danielle Murray

University Honors Theses

This study explores how exposure to sponsored health and fitness content on social media influences users' perceptions of influencer motivation and belief in health-related misinformation. Drawing on parasocial interaction (PSR), attribution theory, and influencer marketing research, this study investigates two hypotheses: that frequent exposure to branded content is positively associated with (1) perceptions of influencers as commercially motivated and (2) belief in pseudoscientific health myths. A cross-sectional online survey (N = 104) was conducted using convenience sampling of adult social media users. Results partially supported the first hypothesis: exposure frequency was positively correlated with recognition of persuasive intent, but …

An Exposition Of "Probabilistic Polynomials And Hamming Nearest Neighbors", Vivek Srirama

University Honors Theses

This paper is an exposition of the paper Probabilistic Polynomials and Hamming Nearest Neighbors by Josh Alman and Ryan Williams. It presents the findings of this paper in a more accessible format for Computer Science students earlier in their career who may not be as familiar with Computational Theory and its concepts as their PhD counterparts are. The paper assumes that the reader has a basic understanding of Algorithms and Complexity, typically obtained in an introductory level Algorithms course.

The paper by Alman and Williams analyzes a specific problem known as the Hamming Nearest Neighbor problem. All known solutions for …

Identity, Bodies, And Time: Analysis Of Transgender Education Curricula In K Through 12 Grades, Dean Weiler-Zilberman

University Honors Theses

The author analyzes lesson plans that focus on education around gender and transgender subjects--sourced from Sexual Orientation and Gender Institute (SOGI) 123 and Advocates for Youth (AFY)--and puts them in conversation with key literature on transgender education. What surfaces from their interaction are clear strong areas that support transgender education and gaps that fail transgender students.

Alloparenting And Male Infant Care Behaviors In Varecia Rubra (Red-Ruffed Lemur), Noelle Wilcox

University Honors Theses

Nonhuman primates are known for their complex social structures that sometimes includes cooperative breeding strategies. In recent years there has been an increase in investigating alloparenting (infant care provided by an adult or subadult that is not a genetic parent) and male infant care, and how such behaviors contribute to the overall assistance to the extreme energetic investment and costs of the mother for the rearing of offspring. There is also debate to how male care has evolved in the primate clade, be it through the theory of kin selection or theory of mutualism. However, there is not enough research …