Digital Commons Network^™

Some Likelihood-Based Methods For Clustering Functional Data, Tong Shan

Theses and Dissertations

The analysis of functional data is an increasingly relevant part of statistics. The exploratory data analytic method of cluster analysis plays a very important role in different fields. Over the years, researchers have developed many clustering approaches, striving to achieve more accurate and efficient clustering. In Chapter 1, we aim to improve the accuracy of our outcome when clustering functional data. To achieve this goal, we use a predictive likelihood function which serves as an objective function to optimize in order to determine the most appropriate clusters. To optimize the objective function over the space of clustering partitions, we produce …

Saw Biosensor For The Detection Of Cyanobacteria And Cyanotoxin, Tally Bovender

Theses and Dissertations

The growing prevalence of cyanobacterial blooms and associated cyanotoxins, such as microcystin-LR (MC-LR), presents a significant threat to water quality and public health. Conventional detection methods, including ELISA and PCR, are often time-consuming, expensive, and require trained personnel, limiting their application in field settings. Hence, a miniaturized, quick testing sensor is proposed to circumvent the current sensing challenges for real time, in-situ diagnostics of MC-LR. The proposed high-frequency ultrasonic sensor employs surface acoustic waves (SAW). The sensor was designed using a multi-physics simulation tool to understand wave propagation in the piezoelectric substrate (lithium tantalate) and optimize the design of the …

Aggressive, Adaptive, And Underestimated: From Allergy To Arboviruses, The Rise Of The Lone Star Tick, Emily Ellen Owens Pickle

Theses and Dissertations

Once considered a nuisance with little medical importance, the lone star tick (Amblyomma americanum, Acari:Ixodidae) has emerged as a formidable vector driving a new era of public health threats across the United States of America. This dissertation traces the rise of the lone star tick from obscurity to infamy, exploring its expanding geographic range, unique immunologic impacts on humans, and role in the transmission of emerging tickborne viruses. Through a series of integrated studies, this work characterizes the epidemiology, immunology, and ecological context of tick-borne diseases in the southeastern U.S., with a particular focus on α-Gal syndrome (AGS), …

Optical And Thermal Characterization Of Vertically Conducting Β-Ga₂O₃ Diodes Grown On 4h-Sic Substrates For Short-Wavelength (<254 Nm) Detection, Muhammad Hassan Tahir

Theses and Dissertations

The advancement of compact, thermally stable, and efficient devices for deepultraviolet (DUV) detection below 254 nm is critical for solar-blind sensing, radiation monitoring, and high-power electronics. This thesis presents the growth, fabrication, and detailed optical and thermal characterization of vertically conducting β-gallium oxide (βGa₂O₃) Schottky barrier diodes (SBDs) grown on n-type 4H-Silicon Carbide (4H-SiC) substrates using metal-organic chemical vapor deposition (MOCVD).

β-Ga₂O₃ is an ultra-wide bandgap (UWBG) semiconductor (~4.8 eV) with intrinsic DUV transparency and high breakdown electric field, making it an ideal candidate for short-wavelength photodetection. However, its low thermal conductivity limits its vertical device performance. To overcome this, …

Multi-Task Deep Learning Approach For Segmenting And Classifying Competitive Swimming Activities Using A Single Imu, Mark Shperkin

Theses and Dissertations

Competitive swimming performance analysis has traditionally relied on manual video review and multi-sensor systems, both of which are resource-intensive and impractical for everyday training use. This study investigates whether a single wrist-worn inertial measurement unit (IMU) can be used to automatically segment and classify swimming activities with high accuracy. We propose a multi-task deep learning pipeline based on the MTHARS (Multi-Task Human Activity Recognition and Segmentation) architecture introduced by Duan et al. to perform stroke classification, lap segmentation, stroke count estimation, and underwater kick count estimation. Data were collected from eleven collegiate-level swimmers wearing left-wrist-mounted IMUs, each performing five 100-yard …

Effect Of Growth Conditions On The Performance Of Vertically Conducting Beta-Ga2o3 Diodes On 4h-Sic Substrate By Mocvd, Nifat Jahan Nipa

Theses and Dissertations

This thesis highlights the critical influence of doping strategies, specifically co-delta doping with silicon (Si) and indium (In), on improving the structural quality and device performance of β-Ga₂O₃-based Schottky barrier diodes (SBDs). To achieve better thermal management, β-Ga₂O₃ thin film was grown on bulk 4H-SiC substrates using the Metal-Organic Chemical Vapor Deposition (MOCVD) technique, renowned for its precise control over composition, thickness and doping profile. The ultra-wide bandgap (UWBG), high critical breakdown field and low turn-on resistance of β-Ga₂O₃ make it a strong candidate for next-generation power electronics and short-wavelength detection in extreme environments. However, the presence of structural defects …

The Impact Of Adverse Childhood Experiences And Living With Hiv On Cardiovascular Health And Cardiometabolic Disorders In An African Population: An Analysis Of The Indepth Community In Rural South Africa, Samuel Gavi

Theses and Dissertations

Background: Adverse Childhood Experiences (ACEs) have been shown to be associated with cardiometabolic disorders (CMDs) and poor CVH; however, in Africa, this has not been well studied. Cardiovascular health (CVH) is an important measure of risk for cardiovascular diseases (CVD) developed by the American Heart Association (AHA). With the increasing prevalence of CVD in Africa, CVH is a potential upstream prevention approach. Africa also has the highest prevalence of HIV, and an increasing prevalence of comorbidities associated with it. Various mechanisms have been investigated to explain the relationship between CVD and chronic HIV infection. This study explores the potential relationship …

Causes And Effects Of Science Tutor Attrition At The Colleges Of Education In The Northern Zone Of Ghana: A Qualitative Study, Collins D. Amadu, Rose Dognia, Solomon Boachie, Taarique-Ahmad Yahaya

Journal of Global Education and Research

The study investigated the causes and effects of science tutor attrition in the colleges of education in the Northern Zone of Ghana. Three science and mathematics colleges were used for the study. The study adopted a qualitative approach with 9 participants who volunteered to take part. The interview guide was the sole instrument for data collection. The interviews were conducted through face-to-face and phone calls. The recorded conversations were transcribed and categorized into themes. The study found that the science tutor attrition rate was caused by several factors. These factors could be grouped into unmet expectations of the tutors and …

Effectiveness Of Digital Learning Materials On Students' Achievement In Science: A Meta-Analysis, Bingo L. Aligo, Maricar S. Prudente

Journal of Global Education and Research

Researchers have been examining educational resources and content to enhance and support the learning experience. As technology continues to transform the way we learn and access information, digital learning materials have become increasingly popular in modern education. This study looked at how different kinds of digital learning materials affected science students’ learning achievement. The moderator variables used were grade level (kindergarten, primary, intermediate, and secondary), subject (biological sciences, general science, and physical sciences), and length of exposure (1 to 3 weeks, 4 to 6 weeks, and 10 to 12 weeks). A total of 14 studies were considered, involving 789 students …

Distinguishing Pex2 And Pex16 Gene Variant Severity For Mild, Severe And Atypical Peroxisome Biogenesis Disorders, Vanessa A Gomez, Oguz Kanca, Sharayu V Jangam, Saurabh Srivastav, Jonathan C Andrews, Michael F Wangler

Duncan NRI Faculty and Staff Publications

Peroxisomal biogenesis disorders (PBD) are autosomal recessive diseases caused by mutations in specific PEX genes that impair peroxisome formation, leading to multi-systemic failure. Symptoms vary, even in patients with variants in the same PEX gene. Our goal is to select PEX mutations and use Drosophila to model a severity spectrum based on genotype-phenotype correlations. Utilizing KozakGAL4 (KZ) cassettes, we replaced the coding sequence of Pex with a GAL4 driver, ideal for making 'humanized' flies in which human PEX can replace the fly loss. We generated Pex2KZ and Pex16KZ lines and assessed them in various behavior assays, confirming their severe phenotypes. …

Quality Of Life Outcomes Following Total Temporomandibular Joint Replacement: A Systematic Review Of Long-Term Efficacy, Functional Improvements, And Complication Rates Across Prosthesis Types, Luis Eduardo Almeida, Samuel Zammuto, Louis G. Mercuri

School of Dentistry Faculty Research and Publications

Introduction:

Total temporomandibular joint replacement (TMJR) is a well-established surgical solution for patients with severe TMJ disorders. It aims to relieve chronic pain, restore jaw mobility, and significantly enhance quality of life. This systematic review evaluates QoL outcomes following TMJR, analyzes complication profiles, compares custom versus stock prostheses, explores pediatric applications, and highlights technological innovations shaping the future of TMJ reconstruction.

Methods:

A systematic search of PubMed, Embase, and the Cochrane Library was conducted throughout April 2025 in accordance with PRISMA 2020 guidelines. Sixty-four studies were included, comprising 2387 patients. Results: Primary outcomes assessed were QoL improvement, pain reduction, and …

Effects Of Verbal Tasks On Driving Simulator Performance, Jonathan Cheshire Rann

Theses and Dissertations

We report the results from a driving simulator paradigm we developed to test the effects of simple verbal tasks on simultaneous driving performance. A total of 74 undergraduate students participated in two experiments in which they controlled a car using the steering wheel to track a moving target. The dependent measure, overall deviation from target, was continuously recorded. Experiment 1 (E1) tested tracking performance during slow and fast target speeds under conditions involving either no verbal input or output (Absent), passive listening to spoken prompts via headphones (Listen), or responding to the spoken prompts (Respond). Experiment 2 (E2) was similar …

Stimulation Of The Rostromedial Tegmental Nucleus Induces Long-Lasting Avoidance Behavior, Jacob Ryan Watson

Theses and Dissertations

The role of midbrain dopamine (DA) activity in reward seeking and reinforcement learning is well-documented, contrasting the lesser-understood impact of inhibitory signaling on DAergic activity, especially in the context of aversive learning and avoidance. The rostromedial tegmental nucleus (RMTg) is a GABAergic midbrain structure activated by aversive stimuli and exerts inhibitory influence over ventral tegmental area (VTA) DAergic activity in response to aversive consequences. Stimulation of the RMTg decreases the firing rate of VTA DA neurons and direct inhibition of the RMTg – VTA circuit enhances persistent reward seeking despite aversive consequences, a major criterion of substance use disorder (SUD). …

The Impact Of The Flipped Learning Approach On Student Engagement In A High School Chemistry Classroom, Alana Lyn Hicks

Theses and Dissertations

This mixed-methods action research study investigated the impact of the flipped classroom approach on student engagement and attitudes within a science classroom. Data was collected using student-reported responses on the Classroom Engagement Inventory, Motivated Strategies for Learning Questionnaire, student journal entries, teacher reflective journals, and an observation tracking chart kept by the classroom teacher. Findings revealed that the flipped classroom model significantly increased affective and cognitive engagement among students in a larger class size, as well as for medium-achieving students and girls. These results suggest that while the flipped classroom has the potential to enhance engagement, its effectiveness is influenced …

Lessons In Game Use: Examining Engagement And Content Knowledge With The Use Of Digital Game-Based Learning Lessons In Biology, Rebecca Anne Valencia

Theses and Dissertations

According to both national and local data, students in high school biology classes are disengaged in content learning and do not demonstrate sufficient understanding of the content taught during units focused on the mechanisms of heredity and gene expression. Traditional teaching methods do not hold their interest which leads to disengagement and missed learning opportunities. The purpose of this action research was to evaluate the effect of digital game-based learning lessons on biology 1 students’ engagement and content knowledge application regarding the mechanisms of heredity and gene expression, as well as on the students’ perceptions of their digital game-based learning …

Reassessing Readiness: Physical Performance Trajectories And Future Physical Military Readiness, Giovanna Leone

Theses and Dissertations

This dissertation consists of three studies integrating frequentist and machine learning techniques to examine physical fitness trajectories and future physical military readiness. Study 1 consists of a cross-sectional examination of Physical Fitness Test (PFT) scores from four cohorts of first-year Cadets at a Senior Military College from 2019 to 2022. Study 2 consists of a longitudinal examination of PFT performance from one cohort of Cadets across a baseline test and three years of training at a Senior Military College. Study 3 examines predictive machine learning and growth curve modeling methods to project future physical military readiness based on motor competence …

Characterizing The Relationships Between Cranial Geometry, Brain Morphometry, And Brain Mechanical Properties Using Mr Imaging And Elastography, Jessica Restivo

Theses and Dissertations

Traumatic brain injury (TBI) is a global health concern, with over 69 million cases annually. TBI risk depends on subject-specific neuroanatomical variation, yet research often only considers generic finite element (FE) models, based on the geometry and material composition of a 50th percentile male head. Although highly accurate, subject-specific models require expensive magnetic resonance (MR) imaging, elastography, and time-consuming computational resources. There is a need to create subject-specific TBI models that account for subject-specific variations, without neuroimaging. This study aims to create mathematical models to predict brain morphometry (dimensions, volume) [Objective 1] and mechanical properties (shear stiffness, damping ratio, octahedral …

Level Of Awareness About Diabetic Retinopathy And Eye Checkup Practice Among Type 2 Diabetic Patients Attending Baghdad Teaching Hospital 2023., Ali Olaiwei, Mohammed Ibrahim

Iraqi Postgraduate Medical Journal

Background: Diabetic retinopathy is a common and serious complication of diabetes that can lead to vision loss or even blindness if not detected and treated early. However, some people may not have any symptoms until the condition is advanced. Therefore, regular eye exams with dilated pupils are recommended for people with diabetes to check for signs of diabetic retinopathy and other eye problems regardless of the symptoms.Objectives of the study: To measure patients’ awareness and practices regarding diabetic retinopathy, to detect the barriers for eye screening and receiving eye check-up, and to find if there is any association between level …

Hypothyroidism And The Risk Of Occurrence Of Type 2 Diabetes Mellitus, Farha Rasheed, Basil Saleh

Iraqi Postgraduate Medical Journal

Abstract:Background:Hypothyroidism is a syndrome resulting from deficiency of thyroid hormones leading to general slowdown of many metabolic processesObjectives:This study was designed for investigating the occurrence of type 2 diabetes mellitus among sample of patients with hypothyroidism, as well as Investigate the relationship between fasting serum glucose and glycated hemoglobin levels with thyroid stimulating hormone, free triiodothyronine and free thyroxine Patients and Methods:This is a comparative cross section study include 80 subjects was taken, 40 of them as patients diagnosed with clinical hypothyroidism who are on treatment. The remaining 40 apparently healthy individuals who served as a control group. The diagnosis …

Mtap Immunohistochemistry As A Surrogate Marker Of Cdkn2a Loss In Brain Tumors: A Meta-Analysis And Literature Review, Antonio Dono, Diego Pichardo-Rojas, Leonardo Mendoza Mora, Pavel S Pichardo-Rojas, Luis A Marin-Castañeda, Abril Carrillo, Adrian Coria Medrano, Yoshua Esquenazi, Leomar Y Ballester

Faculty, Staff and Student Publications

Given the known relationship between CDKN2A homozygous deletion (HD) and worsened outcomes in both meningiomas and IDH-mutant astrocytomas, it is paramount to identify CDKN2A HD for accurate risk stratification of patients. Multiple array platforms can detect CDKN2A HD. However, these methods are expensive and are not readily available at every institution. To address this, we conducted a meta-analysis and literature review to evaluate 5'-methylthioadenosine phosphorylase (MTAP) expression determined by immunohistochemistry (IHC) as a surrogate of CDKN2A HD. Our study analyzed 7 cohort studies, 3 of which focused on meningiomas encompassing a total of 87 patients; and 4 studies were conducted …

Functional Assays In Drosophila Facilitate Classification Of Variants Of Uncertain Significance Associated With Rare Diseases, Jung-Wan Mok, Shelley B Gibson, Haley A Dostalik, Shinya Yamamoto

Faculty, Staff and Students Publications

Individuals living with rare diseases often undergo a frustrating and expensive diagnostic odyssey. Clinical geneticists who analyze exome or genome sequencing data from rare disease patients often encounter a list of variants of uncertain significance (VUS) in known disease-causing genes or rare variants in genes of uncertain significance (GUS) that are difficult to interpret, even with the integration of the latest bioinformatic tools. In this Perspective, we review how studies using the fruit fly Drosophila melanogaster have facilitated rare disease diagnosis by uncovering the clinical relevance of GUS and classifying rare variants into specific allelic categories (loss-of-function or gain-of-function, Muller's …

Endothelium- And Fibroblast-Derived C-Type Natriuretic Peptide Prevents The Development And Progression Of Aortic Aneurysm, Aisah A Aubdool, Amie J Moyes, Cristina Perez-Ternero, Reshma S Baliga, Jaspinder Singh Sanghera, M Taaha Syed, Kareemah Jaigirdar, Anmolpreet K Panesar, Janice C Tsui, Yanming Li, Hernan G Vasquez, Ying H Shen, Scott A Lemaire, Juliette Raffort, Ziad Mallat, Hong S Lu, Alan Daugherty, Adrian J Hobbs

Faculty, Staff and Students Publications

Background: Thoracic (TAA) and abdominal (AAA) aortic aneurysm are life-threatening diseases characterized by dilation, inflammation, and structural weakness; development of pharmacological therapies is desperately needed. CNP (C-type natriuretic peptide) plays a key role in vascular homeostasis, mediating vasodilator, anti-inflammatory, and antiatherogenic actions. Since such processes drive AA, we determined the role of endogenous CNP in offsetting pathogenesis.

Methods: Tissue from patients with AA was analyzed to determine the consequences on CNP signaling. Ascending and suprarenal aortic diameters were assessed at baseline and following Ang II (angiotensin II; 1.44 mg/kg per day) infusion in wild-type, endothelium-restricted (ecCNP-/-), fibroblast-restricted (fbCNP-/-), global CNP …

Cryoem Structure Of The Slfn14 Endoribonuclease Reveals Insight Into Rna Binding And Cleavage, Justin Van Riper, Arleth O Martinez-Claros, Lie Wang, Hannah E Schneiderman, Sweta Maheshwari, Monica C Pillon

Faculty, Staff and Students Publications

The SLFN14 endoribonuclease is a post-transcriptional regulator that targets the ribosome and its associated RNA substrates for codon-bias translational repression. SLFN14 nuclease activity is linked to antiviral defense and platelet function. Despite its prominent role in gene regulation, the molecular signals regulating SLFN14 substrate recognition and catalytic activation remain unclear. SLFN14 dysregulation is linked to human diseases, including ribosomopathies and inherited thrombocytopenia, thus underscoring the importance of establishing the signals coordinating its RNA processing activity. Here, we reconstitute active full-length human SLFN14 and report a high-resolution cryoEM reconstruction of the SLFN14•RNA complex. The structure reveals a medallion-like architecture that shares …

Development And Diversity Of Astrocytes, Michael R Williamson, Sanjana Murali, Benjamin Deneen

Faculty, Staff and Students Publications

Proper development of the central nervous system (CNS) depends on astrocytes, which are the most abundant glial cells in the CNS. Here, we provide an overview of astrocyte ontogeny and morphogenesis, highlighting mechanisms that regulate astrocyte development. In addition, we describe the roles of astrocytes in regulating the development of other CNS cell types, with emphasis on neural circuits and vascular networks. We also discuss evidence for astrocyte diversity and its implications for CNS development. Finally, we pose open questions related to astrocyte development and its intersection with astrocyte diversity.

Fetal Body Composition And Organ Volume Trajectories In Association With Maternal Perceived Stress Or Depressive Symptoms In The Fetal 3d Study, Alexandra Jean-Louis, Jessica L Gleason, Zhen Chen, Kathryn A Wagner, William A Grobman, Roger B Newman, Wesley Lee, Robert Gore-Langton, Seth Sherman, John Owen, Deborah A Wing, Daniel W Skupski, Jagteshwar Grewal, Katherine L Grantz

Faculty, Staff and Students Publications

Objectives: Evaluate associations between maternal perceived stress and depressive symptoms, and fetal body composition and organ volumes.

Methods: In the NICHD Fetal 3D Study (2015-2019; n = 2457), stress and depressive symptoms were assessed at enrollment (10-13 weeks). High stress was defined as a Perceived Stress Scale (PSS) score ≥15 and high depressive symptoms, defined as an Edinburgh Postnatal Depression Scale (EPDS) score ≥10. Fetal body composition and organ volumes (cerebellar, lung, liver, and kidney) were measured up to five times between 15 and 40 weeks using three-dimensional (3D) ultrasound technology. Trajectories of body composition and organ volumes across pregnancy …

Metabolomic Data May Support The Development Of Personalized Nutrition Approaches To Type 2 Diabetes Management, Danielle J Lee, Shragvi Balaji, Jerome I Rotter, Alexis C Wood

Faculty, Staff and Students Publications

Diet is a major modifiable risk factor for type 2 diabetes (T2D), and suboptimal diets continue to contribute substantially to the population burden of T2D. Personalized nutrition proponents argue that specializing recommendations to interindividual differences in diet-health relationships will yield reductions in disease risk. However, how to personalize diet, and to whom, to reduce T2D risk remains unclear. Metabolites offer promise in this respect, as they capture (in part) dietary intake after the processes of digestion, processing, and absorption. The incorporation of metabolite data into diet-health studies therefore offers the opportunity to examine how the effects of food on the …

Fgf21 Promotes Longevity In Diet-Induced Obesity Through Metabolic Benefits Independent Of Growth Suppression, Christy M Gliniak, Ruth Gordillo, Yun-Hee Youm, Qian Lin, Clair Crewe, Zhuzhen Zhang, Bianca C Field, Teppei Fujikawa, Megan Virostek, Shangang Zhao, Yi Zhu, Clifford J Rosen, Tamas L Horvath, Vishwa Deep Dixit, Philipp E Scherer

Faculty, Staff and Students Publications

Approximately 35% of US adults over 65 are obese, highlighting the need for therapies targeting age-related metabolic issues. Fibroblast growth factor 21 (FGF21), a hormone mainly produced by the liver, improves metabolism and extends lifespan. To explore its effects without developmental confounders, we generated mice with adipocyte-specific FGF21 overexpression beginning in adulthood. When fed a high-fat diet, these mice lived up to 3.3 years, resisted weight gain, improved insulin sensitivity, and showed reduced liver steatosis. Aged transgenic mice also displayed lower levels of inflammatory immune cells and lipotoxic ceramides in visceral adipose tissue, benefits that occurred even in the absence …

Dynamic Few-Shot Prompting For Clinical Note Section Classification Using Lightweight, Open-Source Large Language Models, Kurt Miller, Steven Bedrick, Qiuhao Lu, Andrew Wen, William Hersh, Kirk Roberts, Hongfang Liu

Faculty, Staff and Student Publications

Objective: Unlocking clinical information embedded in clinical notes has been hindered to a significant degree by domain-specific and context-sensitive language. Identification of note sections and structural document elements has been shown to improve information extraction and dependent downstream clinical natural language processing (NLP) tasks and applications. This study investigates the viability of a dynamic example selection prompting method to section classification using lightweight, open-source large language models (LLMs) as a practical solution for real-world healthcare clinical NLP systems.

Materials and methods: We develop a dynamic few-shot prompting approach to classifying sections where section samples are first embedded using a transformer-based …

Non-Invasive Tools For Analysis Of Plasma Membrane Protein Topology In Living Cells, Daria Savenkova, Leysan Bulatova, Vera Skripova, Ramziya Kiyamova, Mikhail Bogdanov

Faculty, Staff and Student Publications

Membrane protein topology studies offer guidance to membrane protein structure, folding, and function, serving as a credible scaffold for designing site-directed mutagenesis and biochemical experiments, helping to identify functionally significant extracellular and intracellular regions, modeling three-dimensional structures, and building reliable mechanistic models. Membrane protein structure as a function of given lipid composition and physiological state of the cell is best probed in whole intact cells. A described simple and advanced immunofluorescence protocol applied to the transmembrane orientation of extramembrane domains permits a topology analysis of plasma membrane proteins in their native state in living unperturbed eucaryotic cells. The accessibility of …

Long Akap18 Isoforms Anchor Ubiquitin Specific Proteinases And Coordinate Calcium Reuptake At The Sarcoplasmic Reticulum, Taeyeop Park, Katherine Forbush, Yong Li, Oscar Vivas, Kacey J Rosenthal, Jerome Falcone, Cassandra J Wong, James E Bruce, Claudia Moreno, Carmen W Dessauer, John D Scott

Faculty, Staff and Student Publications

Subcellular targeting of signaling enzymes influences where and when various modes of intracellular communication operate. Macromolecular complexes of signal transduction and signal termination elements favor reversible control of repetitive processes. This includes adrenergic stimulation of excitation–contraction coupling in the heart. Long isoforms of A-kinase anchoring protein 18 (AKAP18γ and δ) modulate this process via regulation of calcium uptake into the sarcoplasmic reticulum through the Ca2+ATPase 2a (SERCA2a). AKAP18 proximity-proteomic screening in cardiomyocytes identifies networks for protein kinase A (PKA) and ubiquitin-specific proteinases (USPs). A 2′phosphoesterase domain on AKAP18 interfaces with the USP4 isoform at the Z bands of sarcomeres. PKA …