Digital Commons Network^™

Representation And Visualization Of Multivariate Sensory Time Series Data, Ismail Uysal, Alla Abdella

USF Patents

In accordance with some embodiments, systems, methods, and media for processing and representing multivariate sensor information gathered from multiple sources are provided. In some embodiments, the method comprises: receiving a data sequences from respective sources; identifying a shortest data sequence that corresponds to a first interval; calculating, for pairs of data sequences, a similarity value over the first interval; forming a first segment of a representative data sequence that is a weighted combination of the data sequences over the first interval based on similarity values associated with the data sequences; truncating at least a subset of data sequences to exclude …

Violence Towards Ems, Briana Moffat

AJiC Fact Sheets

This factsheet examines violence towards Emergency Medical Services (EMS) responders as documented in existing research literature, tying into Alaska's Crisis Response Team models.

Relationship Between Indulgent Parenting, Household Composition, And Parental Efficacy In Managing Adolescents' Smartphone Use, Bernice Cook

Walden Dissertations and Doctoral Studies

Smartphones have become an integral part of society, resulting in increased adolescent dependence on smartphone applications. This dependence poses challenges for parents in managing the risk of problematic smartphone use among adolescents aged 11-17 years old. Rapid technological advancements have significantly reshaped parenting practices, necessitating greater adaptability and impacting adolescent development. Guided by Bandura’s self-efficacy theory, this correlational study examines how indulgent parenting and household composition, including demographic variables such as race, gender, education, employment, and income, predict parental self-efficacy in managing adolescent smartphone use. A convenience sample of 238 U.S. parents, with at least one adolescent aged 11-17 years, …

Elucidation Of A Role In Biofilm Production For The Tyrosine Catabolism Pathway In Vibrio Cholerae And Analysis Of Reversible Phase Variation In Vibrio Vulnificus, Aheli S. Mukerji

LSU Doctoral Dissertations

Biofilms produced by the cholera pathogen Vibrio cholerae not only enhance its ability to survive in the environment but also allow pathogenic success of the bacterium. This organism also undergoes phase variation, switching between smooth and rugose colonial phenotypes, the latter forming much more vibrio polysaccharide (VPS) resulting in more robust biofilms and subsequently having an increased level of persistence. In a previous study, many genes were found to be upregulated in the transition from the smooth to the rugose phenotype. Here, several of these upregulated genes were investigated for their potential role in biofilm production, and an additional gene, …

Magnetic Field Enabled Assembly And Propulsion Of Colloidal Particles In A Magnetic Medium, Hashir M. Gauri

LSU Doctoral Dissertations

Colloidal particles are nano/micro meter-sized particles dispersed in a fluid medium and serve as diverse building blocks for assembling complex structures. The ease of tunability of the shape, size, and interparticle interactions of colloidal particles facilitates their assembly into rich structures and phases that mirror the assembly process of atomic systems. Often regarded as "big atoms" colloidal particles provide an ideal model system for investigating complex phenomena in condensed matter, such as crystallization and nucleation. While the assembly of colloids under thermodynamic equilibrium has been extensively studied, recent interest has shifted toward exploring colloids in non-equilibrium conditions to create dynamic …

Modulation Of Redox-Sensitive Cardiac Ion Channels, Rawan S. Orfali, Al Hassan Gamal El-Din, Varnika Karthik, Elisanjer Lamis, Vanna Xiao, Alena Ramanishka, Abdullah Alwatban, Osama Alkhamees, Ali Alaseem, Young-Woo Nam, Miao Zhang

Pharmacy Faculty Articles and Research

Redox regulation is crucial for the cardiac action potential, coordinating the sodium-driven depolarization, calcium-mediated plateau formation, and potassium-dependent repolarization processes required for proper heart function. Under physiological conditions, low-level reactive oxygen species (ROS), generated by mitochondria and membrane oxidases, adjust ion channel function and support excitation–contraction coupling. However, when ROS accumulate, they modify a variety of important channel proteins in cardiomyocytes, which commonly results in reducing potassium currents, enhancing sodium and calcium influx, and enhancing intracellular calcium release. These redox-driven alterations disrupt the cardiac rhythm, promote after-depolarizations, impair contractile force, and accelerate the development of heart diseases. Experimental models demonstrate …

The Role Of Self-Reported Health Ratings In Identifying Hospitalization Risk Among Older Adults: An Integrated Review And Secondary Analyses Of Medicare Claims Data, Mary B. Prybylo

MUSC Theses and Dissertations

Purpose: This study examined how Self-Reported Health (ratings), a person’s own evaluation of their overall health, relates to hospital admissions and emergency department utilization. It further assessed the extent to which demographic characteristics, Risk Adjustment Factor (RAF) scores (used to estimate healthcare expenditures based on clinical complexity), and the number of chronic conditions influence SRH rating and the likelihood of hospitalization.

Problem and Aim: The growing population of older adults places greater demands on healthcare services, leading to increased financial strain and a need for improved care strategies. Primary care teams, particularly those managing older adults, require effective assessment …

Genome-Wide Characterization Of Vdac Gene Family In Soybean (Glycine Max L.) And In Silico Expression Profiling In Response To Drought And Salt Stress, Muhammad Muneeb Ullah, Muqadas Aleem, Mudassar Muhammad Iqbal, Ainong Shi

Horticulture Faculty Publications and Presentations

Soybean (Glycine max L.) is grown worldwide to obtain edible oil, livestock feed, and biodiesel. However, drought and salt stress are becoming serious challenges to global soybean cultivation as they retard the growth of soybean plants and cause significant yield losses. Voltage-dependent anion-selective channel (VDAC) proteins are well-known for their role in drought and salt tolerance in crop plants. In this study, we identified 111 putative VDAC genes randomly distributed in genomes of 14 plant species, including cultivated soybean (Glycine max) and wild soybean (Glycine soja). The comparative phylogenetic studies classified these genes into six different clades and found the …

Remote Sensing-Based Assessment Of Evapotranspiration Patterns In A Unesco World Heritage Site Under Increasing Water Competition, Maria C. Moyano, Monica Garcia, Luis Juana, Laura Recuero, Lucia Tornos, Joshua B. Fisher, Néstor Fernández, Alicia Palacias-Orueta

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

In water-scarce regions, natural ecosystems and agriculture increasingly compete for limited water resources, intensifying stress during periods of drought. To assess these competing demands, we applied a modified PT-JPL model that incorporates the thermal inertial approach as a substitute for relative humidity (RH) in estimating soil evaporation—a method that significantly outperforms the original PT-JPL formulation in Mediterranean semi-arid irrigated areas. This remote sensing framework enabled us to quantify spatial and temporal variations in water use across both natural and agricultural systems within the UNESCO World Heritage site of Doñana. Our analysis revealed an increasing evapotranspiration (ET) trend in intensified agricultural …

Under Pressure: Performance Loads And Recovery In Ncaa Division I Women’S Soccer During Fixture Congestion, Jade X. Dawson, Fabiano T. Amorim

Health, Exercise, and Sports Sciences ETDs

Soccer places high physiological demands on athletes, and match congestion—playing more than two games per week—is a growing concern at the NCAA Division I level. Limited recovery time between matches can impair performance and increase injury risk, prompting widespread use of recovery strategies. However, research on their effectiveness remains inconclusive, and most existing studies focus on male athletes, leaving a gap in evidence specific to female players. This review and observational study aim to evaluate non-nutritional recovery strategies in NCAA Division I women’s soccer and examine how recovery duration influences performance.

Match load data were collected from eleven female athletes …

Involvement Of Microglia In Retinal Ganglion Cell Injury Induced By Iop Elevation In A Rat Ex Vivo Acute Glaucoma Model, Taimu Sato, Makoto Ishikawa, Yukitoshi Izumi, Naoya Shibata, Kota Sato, Michiko Ohno-Oishi, Hiroshi Tawarayama, Hiroshi Kunikata, Charles F Zorumski, Toru Nakazawa

2020-Current year OA Pubs

No abstract provided.

Zoo Visitors Learn By Observing Olive Baboons (Papio Anubis) Participate In Cognitive Research Or Engage In Natural Behaviors, Anna Sofia Hege

Theses

I conducted two experiments at the baboon exhibit at the Seneca Park Zoo in Rochester, New York to measure attitudes and actual knowledge in children and adults, as well as perceived learning in adults. I also recorded caregiver-child conversations in the presence and absence of live research. Experiment 1 included 150 adult participants, and Experiment 2 included 18 caregiver-child dyads. In each experiment, the research on-scientist present and research on-scientist absent group watched the baboons engage with live cognitive research while the research off-scientist present and research off-scientist absent group watched the baboons carry out their natural behaviors. A scientist …

Str Analysis Performance Comparison For Two Capillary Electrophoresis Instruments: The Seqstudio And The 3500 Genetic Analyzers, Yana Leichyk

Student Theses

This study compares the performance of two capillary electrophoresis instruments—the SeqStudio™ Genetic Analyzer and the 3500™ Genetic Analyzer—for forensic short tandem repeat (STR) analysis. Using the GlobalFiler STR kit and certified reference material (SRM 2391d), five key performance metrics were evaluated: sizing precision, signal reproducibility, detection sensitivity, mixture resolution, and overload tolerance. STR profiles were generated from single-source and mixture samples with DNA inputs ranging from 500 pg to 15.6 pg. Both instruments met the < 0.15 bp sizing precision requirement for forensic casework. Signal reproducibility tests showed that the SeqStudio often produced higher average RFU values, but with greater variability, while the 3500 demonstrated more stable signal performance across days and samples. Mixture detection was effective on both platforms up to 1:10 ratios. Dropout of minor alleles began to appear at 1:20 ratios, especially in green and yellow dye channels, on both instruments. Sensitivity studies confirmed full profile recovery down to 62.5 pg, with increasing allelic and locus dropout at lower inputs. Enhanced injection voltage (1.5 kV) did not improve low-template performance. In overload testing (1–5 ng input), the 3500 maintained a consistent signal output, while the SeqStudio exhibited signal suppression at 5 ng, likely due to internal normalization. The SeqStudio exhibited better spectral overlap compensation, with fewer occurrences of spectral bleed-through artifacts. These findings support the use of both platforms in forensic casework, while emphasizing the importance of platform-specific calibration and analytical threshold settings for optimal performance.

The Effects Of Rubber Dam Clamps On Zirconia Crown Restorations, Haley D. Kessler, Albert F. Mcmullen Iii, Hunter Kortum, Edwin Kee, Thomas E. Lallier

School of Dentistry Faculty Publications

Rubber dam isolation is crucial in providing sterility and a controlled environment when performing root canal therapy. Rubber dam clamps have been controversial due to their rigidity and composition, which is thought to cause damage to zirconia full coverage crowns. This study evaluated three types of zirconia crowns anterior 5Y, premolar 4Y, and molar 3Y to assess their resistance to damage from rubber dam clamps. Of the 30 total zirconia crowns that were tested for damage following the usage of rubber dam clamps, no fractures or chips were observed. There was no significant difference between the negative control group, and …

Polymorphic Α-Glucans As Structural Scaffolds In Cryptococcus Cell Walls For Chitin, Capsule, And Melanin: Insights From 13c And 1h Solid-State Nmr, Ankur Ankur, Jayasubba Reddy Yarava, Isha Gautam, Faith J. Scott, Frederic Mentink-Vigier, Christine Chrissian, Li Xie, Dibakar Roy, Ruth E. Stark, Tamara L. Doering, Ping Wang, Tuo Wang

School of Graduate Studies Faculty Publications

Cryptococcus species are major fungal pathogens responsible for life-threatening infections in approximately a million individuals globally each year, with alarmingly high mortality rates. These fungi are distinguished by a distinctive cell wall architecture further reinforced by two virulence-associated layers, melanin and capsule, rendering them insensitive to antifungal agents targeting the cell wall, such as echinocandins. The molecular interplay between these three biomolecular layers remains poorly understood. Here we employ solid-state NMR spectroscopy to examine intact cells of both wild-type and capsule-deficient strains of C. neoformans, along with melanized cells. High-resolution 13C and 1H data revealed five distinct structural forms of …

Infantile Pyknocytosis Revisited: Possible Familial Trend In A Study Of 9 Patients, Aileen Y Hu, Amy M Coffey, Jyotinder N Punia, Andrea N Marcogliese, Choladda V Curry, M Tarek Elghetany

Faculty, Staff and Students Publications

Context.—: Infantile pyknocytosis (IP) is an uncommon cause of transient neonatal hemolytic anemia and hyperbilirubinemia occurring in approximately 10% of cases of unexplained neonatal hemolytic anemia.

Objective.—: To study cases of IP with focus on long-term follow-up, perinatal events, and family history.

Design.—: Cases were prospectively identified during review of peripheral blood smears for neonatal hyperbilirubinemia during an 11-year period. Clinical and laboratory parameters, follow-up data, and family history were recorded.

Results.—: Nine cases of IP were identified from the morphologic recognition of pyknocytes and clinical and laboratory evidence of hemolysis, and included 6 males and 3 females. Age at …

Psilocybin Treatment Extends Cellular Lifespan And Improves Survival Of Aged Mice, Kosuke Kato, Jennifer M Kleinhenz, Yoon-Joo Shin, Cristian Coarfa, Ali J Zarrabi, Louise Hecker

Faculty, Staff and Students Publications

Psilocybin, the naturally occurring psychedelic compound produced by hallucinogenic mushrooms, has received attention due to considerable clinical evidence for its therapeutic potential to treat various psychiatric and neurodegenerative indications. However, the underlying molecular mechanisms remain enigmatic, and few studies have explored its systemic impacts. We provide the first experimental evidence that psilocin (the active metabolite of psilocybin) treatment extends cellular lifespan and psilocybin treatment promotes increased longevity in aged mice, suggesting that psilocybin may be a potent geroprotective agent.

The Benefits Of Exercise Training In Combination With Weight Loss Therapies, Bryan C Jiang, Dennis T Villareal

Faculty, Staff and Students Publications

The primary treatment for obesity involves calorie restriction (CR) to promote dietary weight loss achieved through interventions including behavioral modification, bariatric surgery, and antiobesity medications. In adults with obesity, CR-induced weight loss enhances physical function and improves quality of life, while also reducing the burden of various obesity-related chronic conditions, including hypertension, diabetes, obstructive sleep apnea, and atherosclerotic heart disease. However, it is also associated with a decline in lean mass and bone mineral density, which increases the risk of sarcopenia and osteoporosis. When performed alongside CR, progressive resistance training (RT) attenuates this loss of lean mass and bone mass, …

Strategic Innovation In The Dod Fy 2026 Rdte Budget: Leveraging Disruptive Technologies For Deterrence, Defense, And Command And Control, James Giordano

Strategic Insights

This commentary analyzes the Department of Defense FY 2026 Research, Development, Test, and Evaluation (RDTE) budget and its strategic emphasis on convergent disruptive technologies. The author argues that expanded investment in artificial intelligence, quantum systems, hypersonics, and space capabilities reflects a doctrinal shift toward integrated, multi-domain deterrence and AI-enabled command and control. These technologies are described not merely as tools, but as operational paradigms reshaping force posture, battlefield tempo, and cross-domain warfare. The article also addresses ethical oversight, human–machine teaming, quantum resilience, hypersonic navigation, and the biological and cognitive implications of technological convergence. It concludes that sustained advantage will require …

Pi(4)P Recruits Cide Proteins To Promote The Formation Of Unilocular Lipid Droplets During Adipogenesis And Hepatic Steatosis, Jin Wu, Mingming Gao, Xiaoqin Wu, Yang Liu, Taiping Zhang, Yan Liang, Haixia Yang, Chengxin Ma, Youpi Ye, Chunmei Chang, Peng Li, Feng-Jung Chen, Hongyuan Yang

Faculty, Staff and Student Publications

Lipid droplets (LDs) are evolutionarily conserved organelles that play important roles in metabolism. Each LD is enclosed by a monolayer of phospholipids, distinct from bilayer membranes. The composition of LD surface phospholipids and their impact on LD growth and function remain to be defined. Phosphoinositides mark cellular organelles and regulate organellar function. Here, we demonstrate that PI(4)P decorates a subset of LDs to recruit and activate CIDE proteins. Enhanced expression of ORP2 and ORP5, LD-associated lipid transfer proteins that remove PI(4)P from LDs, abolished the localization and function of CIDE proteins. Blocking the synthesis of PI(4)P on the LD surface …

High-Affinity Cd16a Polymorphism Associated With Reduced Risk Ofsevere Covid-19, Anita E Qualls, Tasha Tsao, Irene Lui, Shion A Lim, Yapeng Su, Ernie Chen, Dylan Duchen, Holden T Maecker, Seunghee Kim-Schulze, Ruth R Montgomery, Florian Krammer, Charles R Langelier, Ofer Levy, Lindsey R Baden, Esther Melamed, Lauren Ir Ehrlich, Grace A Mccomsey, Rafick P Sekaly, Charles B Cairns, Elias K Haddad, Albert C Shaw, David A Hafler, David B Corry, Farrah Kheradmand, Mark A Atkinson, Scott C Brakenridge, Nelson I Agudelo Higuita, Jordan P Metcalf, Catherine L Hough, William B Messer, Bali Pulendran, Kari C Nadeau, Mark M Davis, Ana Fernandez-Sesma, Viviana Simon, Monica Kraft, Christian Bime, Carolyn S Calfee, David J Erle, Joanna Schaenmann, Al Ozonoff, Bjoern Peters, Steven H Kleinstein, Alison D Augustine, Joann Diray-Arce, Patrice M Becker, Nadine Rouphael, Impacc Network, Jason D Goldman, Daniel R Calabrese, James R Heath, James A Wells, Elaine F Reed, Lewis L Lanier, Harry Pickering, Oscar A Aguilar

Faculty, Staff and Students Publications

CD16A is an activating Fc receptor on NK cells that mediates antibody-dependent cellular cytotoxicity (ADCC), a key mechanism in antiviral immunity. However, the role of NK cell-mediated ADCC in SARS-CoV-2 infection remains unclear, particularly whether it limits viral spread and disease severity or contributes to the immunopathogenesis of COVID-19. We hypothesized that the high-affinity CD16AV176 polymorphism influences these outcomes. Using an in vitro reporter system, we demonstrated that CD16AV176 is a more potent and sensitive activator than the common CD16AF176 allele. To assess its clinical relevance, we analyzed 1,027 patients hospitalized with COVID-19 from the Immunophenotyping Assessment in a COVID-19 …

Haploblocks Contribute To Parallel Climate Adaptation Following Global Invasion Of A Cosmopolitan Plant, Paul Battlay, Brandon T. Hendrickson, Jonas I. Mendez-Reneau, James S. Santangelo, Lucas J. Albano, Jonathan Wilson, Aude E. Caizergues, Nevada King, Adriana Puentes, Amelia Tudoran, Cyrille Violle, Francois Vasseur, Courtney M. Patterson, Michael Foster, Caitlyn Stamps, Simon G. Innes, Rémi Allio, Fabio Angeoletto, Daniel N. Anstett, Julia Anstett, Anna Bucharova, Mattheau S. Comerford, Santiago David, Mohsen Falahati-Anbaran, William Godsoe, César González-Lagos, Pedro E. Gundel, Glen Ray Hood, Christian Lampei, Christian Lampei

School of Biological and Marine Sciences

The role of rapid adaptation during species invasions has historically been minimized with the assumption that introductions consist of few colonists and limited genetic diversity. While overwhelming evidence suggests that rapid adaptation is more prevalent than originally assumed, the demographic and adaptive processes underlying successful invasions remain unresolved. Here we leverage a large whole-genome sequence dataset to investigate the relative roles of colonization history and adaptation during the worldwide invasion of the forage crop, Trifolium repens (Fabaceae). We show that introduced populations encompass high levels of genetic variation with little evidence of bottlenecks. Independent colonization histories on different continents are …

Opposing Roles For Myeloid And Smooth Muscle Cell Sting In Pulmonary Hypertension, Ann T Pham, Shiza Virk, Aline C Oliveira, Matthew D Alves, Chunhua Fu, Yutao Zhang, Jimena Alvarez-Castanon, Brian B Lee, Keira L Lee, Radwan Mashina, Katherine E Ray, Patrick Donabedian, Elnaz Ebrahimi, Harsh Patel, Reeha Patel, Duncan Lewis, Zhiguang Huo, Harry Karmouty-Quintana, Li Chen, Lei Jin, Andrew J Bryant

Faculty, Staff and Student Publications

There is an emerging role for stimulator of interferon genes (STING) signaling in pulmonary hypertension (PH) development. Related to this, prior research has demonstrated the relevance of immune checkpoint protein programmed death ligand 1 (PD-L1) expression by immunoregulatory myeloid cells in PH. However, there remains a need to elucidate the cell-specific role of STING expression, and the STING/PD-L1 signaling axis in PH, before readily available disease-modifying therapies can be applied for patients with the disease. Here, through generation of bone marrow chimeric mice, we show that STING-/- mice receiving WT bone marrow were protected against PH secondary to chronic hypoxia. …

Design For Additive Manufacturing: Simultaneous Optimization Of Structural Integrity And Minimal Support Structures, Naresh Ahuja

Doctoral Dissertations and Master's Theses

This dissertation addresses two core challenges limiting the widespread application of Topology Optimization (TO): the difficulty in fabricating its complex designs, especially for Additive Manufacturing (AM), and its significant computational costs. It develops a unified design framework that directly embeds AM constraints such as overhang angles and build direction into robust TO formulations. To enhance manufacturability, two distinct methodologies are proposed. Firstly, a Solid Isotropic Material with Penalization (SIMP) framework introduces a three-stage robust optimization algorithm. Secondly, the Geometric Projection Topology Optimization (GPTO) method inherently integrates overhang constraints by controlling individual geometric components and their inclined angles relative to a …

The Effect Of Temperature For Producing Thayer-Martin Agar Media Using Sheep Blood On Neisseria Gonorrhoeae Growth With Various Inoculums, Ika Ningsih, Kayla Adyapratista Sumadiyo

Indonesian Journal of Medical Chemistry and Bioinformatics

Neisseria gonorrhoeae is a Gram-negative bacterium in the form of diplococci that infects mucous membranes through direct inoculation, is fastidious, and requires special media for growth because it is susceptible to heating and dryness, so it cannot survive long outside its host. Thayer-Martin agar media is a selective culture medium for the diagnosis of Neisseria gonorrhoeae bacterial infections enriched with sheep blood. The purpose of this study was to determine the optimum temperature for various temperature variations of making Thayer-Martin agar when mixing with sheep blood, compared to the temperature according to the manufacturer's procedure. Determining this ideal temperature may …

Total Synthesis And Biological Activity Of "Carbamorphine": O-To-Ch2 Replacement In The E-Ring Of The Morphine Core Structure, Sota Akiyama, Rohini S Ople, Alexander Kremsmair, Nokomis Ramos-Gonzalez, Thomas Nedungadan, Brandon J Kennedy, Kevin Appourchaux, Shainnel O Eans, Bowen A Tsai, Christina Kraml, Xi-Ping Huang, Jay P Mclaughlin, Susruta Majumdar, Richmond Sarpong

2020-Current year OA Pubs

Morphine is a µ-opioid receptor (MOR) agonist and potent analgesic. However, it displays several side effects including respiratory depression and addiction. Here, we show that a single heavy atom replacement in the morphine core structure (O to CH

Mtor Signaling Regulates The Development Of Airway Mucous Cell Metaplasia Associated With Severe Asthma, Katrina M. Kudrna, Luis F. Vilches, Evan M. Eilers, Shailendra K. Maurya, Steven L. Brody, Amjad Horani, Kristina L. Bailey, Todd A. Wyatt, John D. Dickinson

2020-Current year OA Pubs

In asthma, airway epithelial remodeling is characterized by aberrant goblet cell metaplastic differentiation accompanied by epithelial cell hyperplasia and hypertrophy. These pathologic features in severe asthma indicate a loss of control of proliferation, cell size, differentiation, and migration. MTOR is a highly conserved pathway that regulates protein synthesis, cell size, and proliferation. We hypothesized that the balance between MTOR and autophagy regulates mucous cell metaplasia. Airways from individuals with severe asthma showed increased MTOR signaling by RPS6 phosphorylation, which was reproduced using an IL-13-activated model of primary human airway epithelial cells (hAEC). MTOR inhibition by rapamycin led to a decrease …

Cord Blood Proteomics Identifies Biomarkers Of Early-Onset Neonatal Sepsis, Leena B. Mithal, Mark E. Becker, Ted Ling-Hu, Young Ah Goo, Sebastian Otero, Aspen Kremer, Surya Pandey, Nicola Lancki, Yawei Li, Yuan Luo, William Grobman, Denise Scholtens, Karen K. Mestan, Patrick C. Seed, Judd F. Hultquist

2020-Current year OA Pubs

BACKGROUNDSymptoms of early-onset neonatal sepsis (EOS) in preterm infants are nonspecific and overlap with normal postnatal physiological adaptations and noninfectious pathologies. This clinical uncertainty and the lack of reliable EOS diagnostics results in liberal use of antibiotics in the first days to weeks of life, leading to increased risk of antibiotic-related morbidities in infants who do not have an invasive infection. METHODSTo identify potential biomarkers for EOS in newborn infants, we used unlabeled tandem mass spectrometry proteomics to identify differentially abundant proteins in the umbilical cord blood of infants with and without culture-confirmed EOS. Proteins were then confirmed using immunoassay, …

Beliefs About The Causes And Treatment Of Common Mental Illnesses And Suicidality In Rural Uganda, Yang Jae Lee, Rita Mbabazi, Ondine Jevremov, Shakira Nakaweesi, Ella Brodey, Jason Wykoff, Roshan Sivakumar, Rauben Kazungu, Ibrahim Ssekalo, Robert Rosenheck, Alexander C Tsai

2020-Current year OA Pubs

BACKGROUND: Mental illnesses constitute a large and escalating portion of the global burden of disease, particularly in low- and middle-income countries like Uganda. Understanding community perceptions towards mental illness is crucial for developing effective interventions.

AIMS: To explore beliefs about the perceived causes and treatment of common mental illnesses (depression, anxiety, alcohol use disorder) and suicidality in rural eastern Uganda.

METHOD: Qualitative study using 31 in-depth interviews and 4 focus group discussions with healthcare workers, community health workers, community leaders and general community members in Buyende District, Uganda. Vignettes were used to depict mental illnesses to elicit perceptions, and data …

The Devil’S In The Details: Opposition To Demonology In Early Modern Europe, Abigail Pickard

The Purdue Historian

Common assumptions that believers of witchcraft in the early modern period were uneducated fanatics overgeneralize the complex interplay of early modern science and theology. The study of demons, known as demonology, was considered a science. It was a respected field that was studied and debated. Theologians scrutinized, defended, and revised demonological theories. Thinkers turned over foundational concepts and split hairs over the fine details of theology. Since educated scholars were considered authorities on demonology, they repeatedly wrote, talked, and theorized about the topic in a similar fashion to other ideologies of the early modern era. Due to this, authors of …