Digital Commons Network^™

One-Year Clinical Outcomes In Patients With Acute Coronary Syndrome Treated With Clopidogrel Versus Prasugrel Versus Ticagrelor: Results Of The Polish Registry Of Acute Coronary Syndromes (Pl-Acs), Julia M. Umińska, Michał Skrzypek, Małgorzata Ostrowska, Piotr Adamski, Aldona Kubica, Piotr Niezgoda, Robert Gajda, Marek Gierlotka, Bartosz Hudzik, Wiktor Kuliczkowski, Diana A. Gorog, Paul A. Gurbel, Jolanta Siller-Matula, Łukasz Szarpak, Michael Savage, Grzegorz Skonieczny, Udaya Tantry, Przemysław Trzeciak, Eliano P. Navarese, Jacek Kubica, Mariusz Gąsior

Division of Cardiology Faculty Papers

BACKGROUND: Efficient dual antiplatelet therapy is crucial in reducing adverse cardiovascular events in patients with acute coronary syndrome (ACS). Comparative effectiveness between clopidogrel, prasugrel, and ticagrelor remains unclear in real-world settings.

AIMS: The objective was to evaluate one-year clinical outcomes in ACS patients treated with clopidogrel, prasugrel, or ticagrelor using data from the Polish Registry of Acute Coronary Syndromes (PL-ACS).

MATERIAL AND METHODS: This retrospective cohort study analyzed 381 278 ACS patients from the PL-ACS registry from 2009 to 2022, who were treated with clopidogrel, prasugrel, or ticagrelor during hospitalization with a 12-month consistent regimen. The primary outcome was one-year …

Comparing Dosimetric Outcomes Of Static Imrt And Vmat In Accelerated Partial Breast Irradiation For Medially Located, Left-Sided Tumor Beds, Rani Jamil

Masters Projects

Abstract

Introduction: Accelerated partial breast irradiation (APBI) has emerged as a targeted alternative to whole-breast irradiation for early-stage breast cancer, particularly for patients with medially located, left-sided tumors. Static intensity-modulated radiation therapy (IMRT) and volumetric modulated arc therapy (VMAT) offer advanced dose conformity, yet no direct comparisons between static IMRT and VMAT have been conducted specifically for medially located, left-sided APBI, a uniquely challenging anatomical subgroup. This study evaluates dosimetric differences between static IMRT and VMAT plans to determine which modality provides superior target coverage and organ-at-risk (OAR) sparing in left-sided APBI.

Methods: Ten patients with medially located left-sided breast …

Optimizing Tobacco-Free Workplace Programs: Applying Rapid Qualitative Analysis To Adapt Interventions For Texas Healthcare Centers Serving Rural And Medically Underserved Patients, Hannah Wani, Maggie Britton, Tzuan A Chen, Ammar D Siddiqi, Asfand B Moosa, Teresa Williams, Kathleen Casey, Lorraine R Reitzel, Isabel Martinez Leal

Faculty, Staff and Student Publications

Background: Tobacco use is disproportionately high in rural areas, contributing to elevated cancer mortality, yet it often goes untreated due to limited access to care, high poverty and uninsured rates, and co-occurring substance use disorders (SUDs). This study explored the utility of using rapid qualitative analysis (RQA) to guide the adaptation of a tobacco-free workplace program (TFWP) in Texas healthcare centers serving adults with SUDs in medically underserved areas.

Methods: From September-December 2023 and May-July 2024, we conducted 11 pre-implementation, virtual semi-structured group interviews focused on adapting the TFWP to local contexts (N = 69); 7 with providers (n …

The Histone H3 Lysine 36 Demethylase Kdm2a/Fbxl11 Controls Polycomb-Mediated Gene Repression And Germ Cell Development In Male Mice, Michael T Bocker, Grigorios Fanourgakis, Kristie Wetzel, Pavel A Komarov, Hélène Royo, Alexia Rohmer, Sunwoo Chun, Ching-Yeu Liang, Hubertus Kohler, Taiping Chen, Xiaohong Mao, Mark A Labow, Reginald A Valdez, Michael B Stadler, Dirk G De Rooij, Paola Capodieci, John Tallarico, Antoine H F M Peters, Thomas B Nicholson

Faculty, Staff and Student Publications

KDM2A/FBXL11 is a Jumonji-domain containing lysine demethylase catalyzing the removal of mono- and di-methyl modifications of histone H3 lysine 36 (H3K36me1/2). While Kdm2a is required for mouse embryogenesis, its role in adult physiology has been largely unexplored. Using conditional deletion approaches, we demonstrate that Kdm2a deficiency leads to testicular atrophy and male infertility. Although spermatogonial stem cells remain unaffected, proliferating and differentiating spermatogonia exhibit delayed cell cycle progression and apoptosis. RNA-sequencing of purified spermatogonia and spermatocytes reveals Kdm2a-dependent repression of over 750 genes during spermatogonial differentiation. Chromatin immunoprecipitation followed by sequencing (ChIP-seq) demonstrates increased H3K36me2 levels at CpG-rich gene promoters …

The Microtubule-Severing Enzyme Spastin Regulates Spindle Dynamics To Promote Chromosome Segregation In Trypanosoma Brucei, Thiago Souza Onofre, Qing Zhou, Ziyin Li

Faculty, Staff and Student Publications

Microtubule-severing enzymes play essential roles in diverse cellular processes, including mitosis and cytokinesis, by modulating microtubule dynamics. In the early branching Trypanosoma brucei, microtubule-severing enzymes are involved in cytokinesis and flagellum length control, but none of them have been found to regulate mitosis. Here we report the characterization of the microtubule-severing enzyme spastin in the procyclic form of T. brucei. We demonstrate that spastin severs microtubule in vitro and overexpression of spastin disrupts spindle microtubules in vivo in trypanosomes, leading to defective chromosome segregation. Knockdown of spastin impairs spindle integrity and disrupts chromosome alignment and segregation. We further show that …

Constitutive Il-7 Signaling Promotes Car-Nk Cell Survival In The Solid Tumor Microenvironment But Impairs Tumor Control, Matthew Dysthe, Ishwar Navin, Dayenne Van Leeuwen, Josue Pineda, Corrine Baumgartner, Cliona M Rooney, Robin Parihar

Faculty, Staff and Students Publications

Background: Adoptive transfer of chimeric antigen receptor (CAR)-expressing natural killer (NK) cells has demonstrated success against hematological malignancies. Efficacy against solid tumors has been limited by poor NK cell survival and function in the suppressive tumor microenvironment (TME). To enhance efficacy against solid tumors, stimulatory cytokines have been incorporated into CAR-NK cell therapeutic approaches. However, current cytokine strategies have limitations, including systemic toxicities, exogenous dependencies, and unwanted TME bystander effects. Here, we aimed to overcome these limitations by modifying CAR-NK cells to express a constitutively active interleukin (IL)-7 receptor, termed C7R, capable of providing intrinsic CAR-NK cell activation that does …

Macrophage-T Cell Interactions Promote Slamf1 Expression For Enhanced Tb Defense, G V R Krishna Prasad, Steven J Grigsby, Gideon A Erkenswick, Cynthia Portal-Celhay, Ekansh Mittal, Guozhe Yang, Samuel M Fallon, Fengyixin Chen, Thais Klevorn, Neharika Jain, Yuanyuan Li, Makedonka Mitreva, Amanda J Martinot, Joel D Ernst, Jennifer A Philips

2020-Current year OA Pubs

CD4+ T cells are crucial for protective immunity to intracellular pathogens. In addition to secreting cytokines, CD4+ T cells promote control of Mycobacterium tuberculosis infection through cognate interactions with macrophages, but the mechanism has been unclear. Here, we show that SLAMF1/CD150 is highly and uniquely induced in macrophages by antigen-specific interactions with CD4+ T cells. In macrophages, SLAMF1 enhances the generation of reactive oxygen species and restricts Mtb replication. Mtb-infection of mice promotes SLAMF1 expression specifically on infected macrophages, not uninfected bystanders. SLAMF1 expression depends on adaptive immunity and also autophagy. Moreover, Slamf1

Sepsis Restructures The Mitochondrial Calcium Uniporter Complex In The Lymphoid Tissues Of Mice And Humans, Xianghong Zhang, Jianguo Lin, Baobo Zou, Jack R Killinger, Andrew C Sayce, Thiagarajan Meyyappan, Zeyu Xiong, Melanie J Scott, Janet S Lee, Matthew R Rosengart

2020-Current year OA Pubs

Survivors of sepsis suffer from an elevated risk of premature death that is not explained by a higher burden of chronic diseases prior to the infection. Nearly 1 out of 4 survivors have persistent elevations of inflammation biomarkers, such as interleukin (IL) 6. These observations suggest that sepsis imparts durable changes to organismal biology. Eukaryotic life depends upon ATP and calcium (Ca

Influence Of Zinc Oxide Nanoparticles On The Efficiency Of Oxytetracycline Removal From Wastewater Using Continuous Catalytic Ozonation, Sarmad Al-Anssari, Hassanain A. Hassan, Maha K. Mohsin, Ahmed A. Mohammed

Research outputs 2022 to 2026

Antibiotics must be fully eliminated before they are released into the environment. In most cases, conventional wastewater treatment systems are not built to handle polar microcontaminants such as antibiotics. Oxytetracycline (OTC) is one of these antibiotics, an environmental hazard contaminant in aqueous solutions. Therefore, an advanced treatment method is needed for wastewater contaminated with antibiotics. In this study, we employed zinc oxide nanoparticles (ZnO), and the catalytic ozonation procedure was employed to increase the ozonation efficiency. A continuous experiment was carried out to compare the effectiveness of catalytic and single ozonation in degrading OTC in a continuous reactor. The flow …

Effects Of Plasma-Activated Water On Wheat: Germination And Seedling Development, Wafaa Abdulrazzaq Abdullah, Hadeel O. Ismael, Duaa A. Uamran, Hammad R. Humud

Karbala International Journal of Modern Science

The food sector must contend with issues such as pathogen resistance to some of the available chemical agents, environmental pollution, and climate change to provide healthy food for livestock and people. The application of atmospheric pressure plasma jets (APPJs) is one potential solution for such problems. Plasma is appropriate for effective surface decontamination regarding food products and seeds, surface decontamination, and achieving improved agricultural production yields. The impact of plasma-activated water (PAW) produced by plasma jet discharge (PJD) system on in vitro-cultivated wheat seeds is examined in this work. For this aim, a plasma jet system was constructed with a …

46,Xx Disorders Of Sex Development: A Case With P.Arg92trp Variant In Nr5a1, Mehmet Ali Oktay, Agah Akin, Esra Döğer, Gülsüm Kayhan, Gizem Eşme Kocaman, Mahmut Orhun Çamurdan, Aysun Bi̇deci̇

Journal of Pediatric Genetics

Ovotesticular (OT) disorders of sex development (DSDs) are marked by the simultaneous presence of ovarian and testicular tissues within the gonads. The appearance of external genitalia does not necessarily correlate with gonadal histology. Variants in the NR5A1 gene can result in SRY-negative DSD. In this report, we present a case involving a variant in the NR5A1 gene. A 3-year-old phenotypic male presenting with micropenis, penile hypospadias, and a bifid scrotum was identified to have a c.274C > T, p.Arg92Trp variant in the NR5A1 gene, along with a 46, XX karyotype. Genetic factors such as variants in the NR5A1 gene, independent of …

A New Case Of Kilquist’S Syndrome With A Novel Variant In Slc12a2 And A Brief Review Of The Literature, Hatice Yelda Yalçin, Yiğithan Güzin, Tayfun Cinletil, Berk Özyilmaz, Gamze Uzan, Melis Köse, Figen Baydan

Journal of Pediatric Genetics

Background: Kilquist syndrome (KILQS) is a recently characterized, rare disorder characterized by hearing loss, secretory dysfunction, gastrointestinal system (GIS) abnormalities, and neurological anomalies including hypotonia and global developmental delay. It is caused by variants in the SLC12A2 (Solute Carrier Family 12 Member 2) gene which encodes the Na-K-2Cl cotransporter isoform 1 (NKCC1). Objective: This study aims to contribute to genotype-phenotype correlations for SLC12A2 variants. Material and Methods: We evaluated a Turkish patient with a novel variant in SLC12A2 gene and reviewed all previously reported cases with Kilquist syndrome. Whole exome sequencing and Sanger sequencing were used as molecular genetic testing …

A Child With Non-Growth Hormone-Deficient Short Stature With Chromosome 2 Deletion Of 2q35-36.1: A Case Report And Literature Review Of Haploinsufficiency Of Epha4 Gene, Jun Sun, Ya Xiao, Shu-Qin Jiang, Yi-Fan Wang, Hong-Ru Zhang, Wei Wang

Journal of Pediatric Genetics

Non-growth hormone-deficient short stature is a group of growth developmental disorders with complex pathophysiological mechanisms involving multiple pathways, including abnormalities in the growth hormone/insulin-like growth factor 1 signal pathway. We report a 4-year-old girl with severe growth and developmental delay: her height was 91 cm (<–3 standard deviation [SD]), and her growth rate was 3 to 4 cm/year (<–2 SD). Growth hormone stimulation tests indicated a normal peak growth hormone level (11.1 μg/L), while insulin-like growth factor-1 levels were reduced (7.98 nmol/L, <–1SD). Whole exome sequencing and copy number variation analysis revealed a 3.19 Mb deletion at 2q35-q36.1 on chromosome 2, encompassing all coding regions of the Epha4 gene. This study suggests an association between Epha4 gene deletion and non-growth hormone-deficient short stature, highlighting the importance of further research on this gene and its related signaling pathways to understand the molecular mechanisms of the disease and potential therapeutic approaches.

Modulation Of Dendritic Cell Phenotypes By Cd4+ Effector Memory T Cell Via Ikzf1-Regulated Il16/Cd4 Signaling In Covid-19 And Kawasaki Disease, Seyan Yan, Kaiming Zheng, Zicheng Zhen, Tianfu Xu

Journal of Pediatric Infectious Diseases

Objective: Kawasaki Disease (KD) is the primary cause of acquired heart disease among children in developed countries and is identified by systemic vasculitis of unknown origin. This research explores the possible common pathogenesis between KD and coronavirus disease 2019 (COVID-19), focusing on the roles of peripheral blood mononuclear cell (PBMC) subpopulations. Methods: We utilized single-cell and bulk RNA sequencing data from COVID-19 and KD patients, as well as healthy controls. Our comprehensive analysis included cell-type identification, pseudotime analysis, cell-cell communication, and transcription factor analysis. Results: Our results show the critical role of CD4+ effector memory T cells and dendritic cells …

Prognostic Value And Clinical Influence Of Long Non-Coding Rna Small Nucleolar Rna Host Gene 1 Expression In Pediatric Pneumonia, Xin Wang, Jiajia Xu, Jingjing Han

Journal of Pediatric Infectious Diseases

Objective: Severe pediatric pneumonia is characterized by acute onset and rapid progression, posing a serious threat to patients' lives. Accurate assessment of the severity of pneumonia is essential for clinical decision-making and prognostication. Studies of acute lung injury and lung cancer have revealed a significant increase in the expression of the long non-coding RNA (lncRNA) small nucleolar RNA host gene 1 (SNHG1) in cells, suggesting that SNHG1 is likely to play an important role in the progression of lung disease. Methods: 72 children with mild pneumonia, 58 children with severe pneumonia and 135 healthy children were selected as study subjects. …

Multisystem Inflammatory Syndrome In Children Associated With Covid-19 Infection: A Comprehensive Review, Alejandra Isabel Meza-Contreras, Marcelo Nicolas Galdos-Bejar, Raffo Escalante-Kanashiro

Journal of Pediatric Intensive Care

Objectives: The Multisystem Inflammatory Syndrome in Children (MIS-C) is a post-infectious syndrome associated with COVID-19 disease in children. The aim of this study is to conduct a thorough review to assist healthcare professionals in diagnosis and management of this complication of COVID-19 disease in children Material and Methods: A thorough systematic review was conducted through an on-line search based on MIS-C with the primary focus on epidemiology, clinical characteristics, diagnosis, pathophysiology, management and long-term follow-up. Results: This syndrome is characterized by an exaggerated and uncontrolled release of pro-inflammatory cytokines involving dysfunction of both innate and adaptive immunity. In this review, …

Correlation Of Ultrasound-Based Hydration Assessment Measures With Cvp And Clinical Hydration Status Among Children Admitted To The Picu: A Prospective Observational Study, Sandeep Tripathi, Tara Osman, Mina Hafzallah, Kejin Lee, Drew A. Whalen

Journal of Pediatric Intensive Care

Purpose: To assess the correlation of respiratory variation in IVC with CVP in children. Secondary objective was to evaluate IVC variability with clinical hydration status. Methods: IVC variability assessed at the subcostal (SC), and right lateral (RL) region and collapsibility index (CI) (spontaneously breathing) and distensibility index (DI) (positive pressure) and IVC/Aortic ratio calculated. Partial correlations calculated between CI/DI with CVP adjusting for BMI & age. Sensitivity of CI & DI to predict clinical dehydration calculated using ROC curves. Results: 145 ultrasounds on 72 patients (41% positive pressure). Only RL CI in spontaneously breathing patients strongly correlated with CVP (r …

Analytical Solution And Stability Of Ψ-Prabhakar Delayed Systems: Application To Antibiotic Production, Mustafa Aydin

Turkish Journal of Mathematics

The analytical solution of the linear ψ -Prabhakar delay differential equations is explored using the method of variation of parameters, in which a ψ -general delayed exponential matrix function is introduced. The ψ -Prabhakar calculus is enhanced in terms of the semi-group property, inversion results, and several simplified calculations and relations. The system's stability is analyzed within the framework of Ulam-Hyers stability. Finally, the theoretical findings are validated through an application to antibiotic production.

On The Solutions Of Difference Equations Of The Volterra Type, Hakan Adigüzel

Turkish Journal of Mathematics

In this paper, we conduct a thorough analysis of the qualitative behavior of solutions to three different types of difference equations of the Volterra type. Utilizing the principles of discrete calculus and various well-known inequalities, we have presented our findings. To conclude our theoretical findings, we provide several examples that illustrate full alignment with the findings.

Templating Of Monomeric Alpha-Synuclein Results In Inflammation And Snpc Dopamine Neuron Death In A Genetic Mouse Model Of Induced Synucleinopathy, Matthew D. Byrne, Peyman Petramfar, Jae-Kyung Lee, Richard J. Smeyne

Department of Neuroscience Faculty Papers

While the etiology of most cases of Parkinson's disease (PD) are idiopathic, it has been estimated that 5-10% of PD arise from known genetic mutations. The first mutations described that leads to the development of an autosomal dominant form of PD are in the SNCA gene that codes for the protein alpha-synuclein (α-syn). α-syn is an abundant presynaptic protein that is natively disordered and whose function is still unclear. In PD, α-syn misfolds into multimeric b-pleated sheets that aggregate in neurons (Lewy Bodies/neurites) and spread throughout the neuraxis in a pattern that aligns with disease progression. Here, using IHC, HC, …

Single-Step Conversion Of Metal Impurities In Cnts To Electroactive Metallic Nitride Nanoclusters For Electrochemical Co2 Reduction, Ahmed Badreldin, John Pellessier, Francisco Alejandro Ospina Acevedo, Siyuan Fang, Carter Racine, Jin Feng, Alvin Chang, Yulu Ge, Yang Gang, Shengyao Wang, Xiaokun Yang, Sergei Ivanov, Zhenxing Feng, Yun Hang Hu, Perla B. Balbuena, Ying Li

Michigan Tech Publications

A novel single-step low-temperature pyrolysis method is developed to efficiently remove encapsulated Ni nanoparticles (NPs, 10–50 nm) from both regular-grade (< 5 wt.% metal impurities) and industrial-grade (< 10 wt.% metal impurities) carbon nanotubes (CNTs). This approach eliminates the need for conventional multi-step purification processes, which often involve high-temperature corrosive gas oxidation and acid washing. The new strategy transforms and redistributes encapsulated Ni-NPs into homogeneously sized nanoclusters (NCs, ≈1 nm) that are evenly dispersed on the surface of CNTs. Surface and bulk sensitive spectroscopic analyses reveal the predominant formation of Ni3N-NCs, along with some metallic Ni-NCs. The treated materials demonstrate exceptional electroactivity toward CO2 reduction to CO, with the best-performing CNT-PTFE-Mel-650 sample achieving an ultra-low onset overpotential of −19 mV and 98% CO selectivity in a current density range of 100–700 mA cm⁻². This NC catalyst demonstrates 25% lower voltage at 700 mA cm⁻² compared to the single atom catalyst (SAC) control. Experimentally verified ab initio molecular dynamics (AIMD) models are simulated, and subsequent density functional theory (DFT) calculations further support the thermodynamic stability of Ni3N-NCs and their favorability for CO2 reduction. This work establishes a new method for creating ligand-free electroactive NCs for efficient electrochemical reactions.

Implementing A Health Recommendation System From Wearable Data, Priti Pramanick

Doctoral Theses

The rising interest in personalized health monitoring has created a demand for intelligent systems that not only evaluate an individual’s health status but also offer actionable recommendations. This dissertation presents a data-driven approach to assess overall health by calculating a weekly health score using multi-dimensional data sources such as sleep patterns, nutrition, cardiovascular activity, fitness levels, and metabolic parameters. The system integrates and processes data stored in MongoDB using Python, applies scoring logic tailored to each health domain, and aggregates them into a unified health score. Addi- tionally, the system generates a detailed summary and leverages a language model to …

Design And Investigation Of Triarylamine Functionalized Luminophores For Multi-Functional And Stimuli-Responsive Applications, Sasikala R

Theses and Dissertations

Organic solid-state fluorescent materials have garnered attention over many decades in virtue of their contribution in the development of LED devices and biomedical applications. Nevertheless, the potential of fluorescent molecules in device applications was underused due to aggregation-caused quenching (ACQ) effect. The ACQ effect commonly quenches the organic molecules fluorescence intensity in the aggregated or condensed state, which can significantly influence their performance in practical applications.

The organic polyaromatic fluorophores exhibit strong fluorescence in the solution state. After culmination of years of work, Prof. Tang’s research group discovered a new phenomenon of aggregation-induced emission (AIE) in the fluorescence molecules constructed …

If We Must, We Must: A Better Way To Utilize Placement Exams, Samantha Bravo

Masters Theses (Archived)

College placement exams have been part of a student’s continuing education journey for many years. In a state like Texas, who has had a very extensive and dynamic history in regard to education assessment, students wishing to enter into college must take a state specific college placement exam. Is this state specific placement instrument helping its students? Texas pioneered a shift to a college and career ready focused state curriculum, so does this focused curriculum prepare students for the state college placement exam? How can this potentially be used in a way that can better serve its students? By analyzing …

Focus, 2025, Spring, Andrews University

Focus

FOCUS (ISSN 1077-9345) is published quarterly, free of charge, for alumni and friends of Andrews University, an institution owned and operated by the Seventh-day Adventist Church.

Potential Impact Of Artificial Intelligence On The Practice And Profession Of Speech-Language Pathology: A Working Paper, Manish Rami

Communication Sciences & Disorders Faculty Publications

This paper explores the potential impact of Artificial Intelligence (AI) on the profession of Speech-Language Pathology (SLP). AI is widely recognized as a transformative force, presenting opportunities across both service delivery and professional practice in SLP. This paper examines how AI may partially or fully automate and augment key tasks such as screening, assessment, and treatment. It also addresses associated challenges, including data bias and the “black box” problem while advocating for proactive engagement with AI technologies. Finally, the paper posits that AI will reshape the field, serving as a collaborative partner for SLPs, enhancing efficiency, and expanding access to …

Curses & Versus: A Soldier's Life In Verse, Robert M. Haynes

Masters Theses

Every life is complicated. Since the Fall of Man, humans have used art to probe the tumult of the living and give meaning to the dead. The challenge comes when an artist must capture brief moments that define their work or explain the force that impelled their creations. What follows is my attempt to harness five aspects that contributed this work, the process of writing it, and its significance to the wider literary world. The snapshots presented stand on their own and do not require the others to make sense. However, when taken together they present the whole of a …

Nutrition, Physical Activity, Faith, And C-Reactive Protein As Predictors Of Depression In A Large Prospective Sample, Rebecca L. Banning

Clinical Psychology Dissertations

Depression is an increasingly common mental health concern and has been linked to both lifestyle factors and biological markers of inflammation. This study examined whether physical activity, dietary patterns, and religiosity/spirituality (R/S) predicted depression symptoms through their associations with high-sensitivity C-reactive protein (hs-CRP), a widely used biomarker of inflammation. Using data from the National Longitudinal Study of Adolescent to Adult Health, participants were assessed at Wave II (ages 12–20) and Wave IV (ages 24–32). Predictors included self-reported physical activity, proinflammatory and anti-inflammatory diet composites, and R/S engagement. Outcomes included concurrent and prospective depression symptoms, as well as hs-CRP concentrations. Results …

No Evidence Of Pitavastatin Effect On Muscle Area Or Density Among People With Hiv, Kristine M Erlandson, Triin Umbleja, Heather J Ribaudo, Michael T Lu, Jana Taron, Marissa R Diggs, Pamela S Douglas, Kathleen V Fitch, Carl J Fichtenbaum, Markella V Zanni, Judith A Aberg, Maria C Rodriguez-Barradas, Katharine Breaux, Rosalba Gomez Morones, Craig A Sponseller, Judith S Currier, Gerald S Bloomfield, Sarah M Chu, Alex B Lu, Carlos D Malvestutto, Steven K Grinspoon, Todd T Brown

Faculty, Staff and Students Publications

Background: Skeletal muscle area (MA) and muscle density (MD) are key determinants of physical function and typically decline with increasing age. Statins have well-known musculoskeletal effects but whether statins impact MA or MD is not well established, especially in the setting of randomized treatment.

Methods: REPRIEVE is a double-blind randomized trial evaluating the effect of pitavastatin for primary prevention of major adverse cardiovascular events in people with HIV (PWH). Thoracic paraspinal, pectoralis, and infraspinatus MA and MD were assessed among Mechanistic Substudy participants with CT at baseline and month 24.

Results: Of 804 substudy participants, 510 remained on study treatment …

Type Of Intimate Partner Violence And Association With Perpetrator Demographics, Katrisha Williams

Walden Dissertations and Doctoral Studies

Intimate partner violence (IPV) is a public health concern because of its long-term impact on health and well-being with 1 in 4 American women experiencing some form of IPV. To help understand how age, gender, and race of both, the perpetrator and victim, impact the type of IPV, multiple regression analysis was performed with secondary data from the National Intimate Partner and Sexual Violence survey (N=541). This study used Raewyn Connell’s Theory of Masculinity as a conceptual framework. This theory states that males have a need to show dominance, strength, and suppress emotion, which can inform patterns of violence in …