Digital Commons Network^™

Beyond The Fermi Paradox: Alien Narratives And Chinese Epistemologyin Liu Cixin’S Science Fiction, Siqi Zhao

Kritika Kultura

an all-encompassing heteronormative patriarchal system problematize the context further.

Nonhuman Narratives In World Literature: An Introduction, Biwu Shang, Maria Luisa Torres Reyes

Kritika Kultura

determination in considerable parts (both urban and rural) of India a wide berth. The eventual

Love Is A Molecular Island, Chun-Mei Chuang

Kritika Kultura

When clarifying Spinoza’s concept of affect, Deleuze declares, “Hope as such or love as such represents nothing, strictly nothing.” In this paper, I approach the question of love by taking a detour of nonhuman affinity. First, I present this paper as an experimental becoming that weaves through heterogeneous lines of thinking and creating. Second, explicating the Deleuzian-Guattarian notion of “abstract machine” alongside Isabelle Stengers’s figure of “inappropriable unknown,” I argue for viewing the cosmos and art as interconnected abstract machines that foster novel realities and communities. Third, I weave planetary thinking with an interdisciplinary approach to propose a “planetary art …

Literary Study In The Era Of Artificial Intelligence In China, Fen Gao, Pengfei Zhang

Kritika Kultura

In view of the salient characteristics of technological innovation and human-machine symbiosis in the era of artificial intelligence, Chinese literary circles have purveyed a productive exploration of “literary study in the era of artificial intelligence.” Chinese scholars’ innovation of literary theory consists of three characteristics. First, they have established the original theory of “brain text,” systematically analyzed the definition, formation mechanism, and relationship between “brain text” and literature, language, text, and cognition, and applied this theory to literary criticism. Second, on the basis of sorting out and summarizing the core viewpoints of Western digital humanities theory, Chinese scholars have carried …

The Dynamics Of Urbanization And Changes In Ekistics Elements: A Case Study Of Surakarta City, Sarah Astita

Cities and Urban Development Journal

Urbanization has become a driving force behind significant spatial, environmental, and socio-economic transformations in urban areas, including Surakarta, the most densely populated city in Central Java. The rapid increase in population and urban expansion has led to drastic changes in land use and the structure of human settlements. This study aims to analyze the impact of urbanization on the ekistic elements of Surakarta (nature, humans, society, space/shells, and networks) and how these changes manifest spatially over time. A descriptive qualitative approach is employed using literature analysis and the interpretation of Landsat satellite imagery from 2011 and 2022. The findings show …

Indirect Genetic Effects Among Neighbors Promote Cooperation And Accelerate Adaptation In A Small-Scale Human Society, Jordan S. Martin, Bret Beheim, Michael Gurven, Hillard Kaplan, Jonathan Stieglitz, Benjamin C. Trumble, Paul Hooper, Daniel K. Cummings, Daniel Eid Rodriguez, Adrian V. Jaeggi

ESI Publications

Explaining the rapid evolution of human cooperation and its role in our species’ biodemographic success remains a major evolutionary puzzle. To address this challenge, we tested a social drive hypothesis, which predicts that social plasticity and social selection in human groups cause indirect genetic effects that accelerate the adaptation of fitness, promoting population growth via feedback between the environmental causes and evolutionary consequences of cooperation. Using Bayesian multilevel models to analyze fertility data from a small-scale society, we demonstrate that density- and frequency-dependent indirect genetic effects on fitness promote the evolution of cooperation among neighboring women, increasing the rate of …

Advancing Interactive Web Cartography Through Designing And Developing An Open-Source, Data-Driven Framework For Accessible Geovisualization Of Geospatial (Big) Data, Sarigai Sarigai

Geography ETDs

The growth of geospatial big data has intensified the demand for open-source, accessible tools for interactive spatial exploration. This dissertation introduces a modular web mapping framework and details its design, extension, and evaluation to advance geovisualization through user-centered, transferable design. The first study presents the original framework, named dciWebMapper, establishing foundational cartographic and information visualization principles, with a focus on modularity and extensibility. The second study extends dciWebMapper with advanced capabilities—such as diverse map types, bivariate visualizations, temporal filtering, spatial querying, and hotspot analysis—and demonstrates its broad transferability across domains. The third study offers a structured usability evaluation of …

Unveiling Food Waste Patterns At Purdue University, Katherine S. Chiparus, Abigail S. Engelberth, Valentina Negri, Louis Tay

Discovery Undergraduate Interdisciplinary Research Internship

Ever wondered how much food waste is generated at Purdue University—or how we compare to other Big Ten schools? This project aims to both evaluate existing practices and behaviors across major universities, and administer a survey to collect data on Purdue’s campus. AI-assisted photo deconstruction and demographic data collection is used to analyze Purdue’s food waste composition and behavior patterns. Concurrently, a comparative analysis of food waste strategies - including categorization of effectiveness, reach, and transparency of waste management efforts while focusing on composting, diversion programs, and dining hall operations - across Big Ten institutions was conducted. To date, the …

Methodology For Environmental Toxicology: Assessing Feeding And Rearing Strategies In Largemouth Bass (Micropterus Nigricans) Larvae, Amber Hitchins, Hannah Mcneese, Deise Cruz, Andrew Todd, Maria Sepúlveda, Tyler Hoskins

Discovery Undergraduate Interdisciplinary Research Internship

Poly- and perfluoroalkyl substances (PFAS) are an anthropogenic group of chemicals known for their persistence in the environment and their potential to bioaccumulate. PFAS can bioaccumulate in largemouth bass (Micropterus nigricans), yet the effects of exposure on bass larvae are unknown. While largemouth bass are commonly raised for aquaculture, techniques for rearing bass which enable controlled experiments at known densities, a necessity for toxicity studies, are poorly understood. Furthermore, the live prey typically used in existing approaches are not suitable for PFAS studies due to high background concentrations. The objective of this project was to assess different venues …

Humans Rule? Implications Of Religious Undergraduates’ Changing Environmental Perceptions, J. Robert Nielson

Undergraduate Honors Theses

Addressing climate change requires correctly appraising one’s ethic toward the Earth. Historically, people have navigated their relationship to the natural world via environmental ethics of both religious and secular origin. Aldo Leopold described developing this relationship via the land ethic, a culturally informed process, as “an evolutionary possibility and an ecological necessity.” A land ethic provides a reference point from which individuals and societies make decisions about the Earth and its resources. This thesis considers the evolving land ethic of a young population of conservative Christian students at Brigham Young University with two separate cohorts of non-biology major undergraduates enrolled …

Open Field Two-Texture Preference Testing Is Not Associated With The Neuropathic Pain-Like Phenotype That Occurs Following Mouse Cervical Contusion Spinal Cord Injury, David A. Jaffe, Megan A. Lyttle, Angelo C. Lepore

Farber Institute for Neuroscience Faculty Papers

Development of neuropathic pain (NP) is one of the major complications associated with spinal cord injury (SCI). While well-established methods such as von Frey mechanical and facial grimace testing are often used to assess SCI-induced NP-like behaviors in animal models, these assays have significant limitations, including experimenter bias and long periods of active testing and analysis. To address these challenges, we aimed to develop a novel open field 2-texture preference test (TTPT) to assess NP-like behaviors following unilateral C5 hemicontusion SCI in mice. To do so, we modified the open field apparatus by introducing both a rough and a smooth …

Gene Regulatory Network Prediction Using Machine Learning, Deep Learning, And Hybrid Approaches, Sai Teja Mummadi, Md Khairul Islam, Victor Busov, Hairong Wei

Michigan Tech Publications

Construction of gene regulatory networks (GRNs) is essential for elucidating the regulatory mechanisms underlying metabolic pathways, biological processes, and complex traits. In this study, we developed and evaluated machine learning, deep learning, and hybrid approaches for constructing GRNs by integrating prior knowledge and large-scale transcriptomic data from Arabidopsis thaliana, poplar, and maize. Among these, hybrid models that combined convolutional neural networks and machine learning consistently outperformed traditional machine learning and statistical methods, achieving over 95% accuracy on the holdout test datasets. These models not only identified a greater number of known transcription factors regulating the lignin biosynthesis pathway but also …

Non-Spectator Behavior Of A Neutral Phosphine Ligand Driven By A Redox-Active Boron Cluster, Jared R. Riffle, Cash L. Jowers, Sarah Luna, Mark D. Smith, Dmitry V. Peryshkov

Faculty Publications

A new concept of ligand ambiphilicity that relies on the redox behavior of the indirectly coordinated boron cluster scaffold instead of the direct involvement of a single center in a ligand is introduced. A copper(I) complex of a carboranyl-based triphosphine, [t^BuP-closo-{C₂B₁₀}-^PhP-closo-{C₂B₁₀}-t^BuP]CuPF₆, in acetonitrile solution coordinates an exogenous X− anion (X− = Cl− or N3−) at the phosphorus center of the ligand and not at the cationic metal site to form [t^BuP(X)-nido-{C₂B …

Ctnna3 Deficiency Promotes Heart Regeneration By Enhancing Cardiomyocyte Proliferation In Neonatal Mice, Sha Zou, Wuhou Dai, Wufan Tao, Jifen Li, Zeyi Cheng, Hongyan Wang

Department of Medicine Faculty Papers

Background: Heart regeneration requires renewal of lost cardiomyocytes. However, the mammalian heart loses its proliferative capacity soon after birth, and the molecular signaling underlying the loss of cardiac proliferation postnatally is not fully understood.

Purpose: This study aimed to investigate the role of Catenin alpha 3 (Ctnna3), coding for alpha T catenin (αT-catenin) protein in regulating cardiomyocyte proliferation and heart regeneration during the neonatal period.

Methods: Here we report that ablation of Ctnna3 and highly expressed in hearts, accelerated heart regeneration following heart apex resection in neonatal mice.

Results: Our results show that Ctnna3 deficiency enhances cardiomyocyte proliferation …

On Expertise Change: The Use And Misuse Of Cultural Evolutionary Models, Ge Fang

Arts & Sciences Graduate Student Theses and Dissertations

Expertise is a major topic in the thoughts of Socrates, Plato, and Aristotle in the West, as well as in the thoughts of Daoist and Buddhist philosophers in the East. Expertise interests ancient philosophers due to the distinctive phenomenology of expertise, the puzzle surrounding the relationship between declarative knowledge and expertise, the practical process of expertise formation, and the use of expertise acquisition as a model for ethical and epistemic development. Philosophical interest in expertise has resurfaced in the last century, particularly regarding the phenomenology of expert performance, the relation between knowledge and expertise, and expertise-based models of ethical and …

The Problem With Consumer Affordability Of Prescription Medications In The United States, Valerie E. Bell

Walden Dissertations and Doctoral Studies

Consumer affordability of prescription drugs is an ongoing problem in the United States. This study was undertaken to research the financial, physical, and economic effects of drug prices on consumers and the methods used by consumers to address such effects. Rational choice and power and politics theories were used to explain the decisions consumers make when they could not afford their medications and the role policies and politics play in drug pricing. The research questions concerned the relationship between consumers’ perceptions of drug pricing and their ability to purchase medications. The quantitative nonexperimental study involved the administration of a survey …

Dosimetric Comparisons Of 6mv, 6fff, 10mv, And 10fff On Vmat Planning In Patients With Endometrial Cancer, Madisin M. Depas

Masters Projects

Purpose: This study aimed to evaluate the dosimetric and efficiency impacts of different photon beam energies—6MV, 6 flattening filter free (FFF), 10MV, and 10FFF—on volumetric modulated arc therapy (VMAT) plans for endometrial cancer, with attention to target coverage, organ at risk (OAR) sparing, and treatment efficiency.

Methods: A retrospective analysis was conducted on 25 patients with post-hysterectomy endometrial cancer. Each patient received four VMAT plans with varying energies. Planning metrics assessed included planning target volume (PTV) dose maximum (Dmax), conformity index (CI), heterogeneity index (HI), OAR doses (bladder, bowel, rectum), and total monitor units (MU). Correlations were drawn …

Experienced Latinx Urban Gardeners In San Jose, Ca, Offer Strategies For Climate Justice And Resilience, Claudia S. Damiani Fontana

Master's Theses

Low-income and underinvested communities will be disproportionately affected by climate change due to limited resources, inadequate infrastructure, and insufficient support systems. Urban gardeners are responding to the need to adapt to new climate conditions while sustaining their food sources and cultural practices. Many have adapted thanks to local interventions led by the government and non-profit agencies. For this study, I partnered with La Mesa Verde (LMV), a gardening and food justice program that works with low-income Latinx families in San José, and I documented the contributions of experienced Latinx gardeners, especially those with agricultural backgrounds, to climate-resilient gardening in San …

Social Justice & Advocacy In Human Services, Cailyn F. Green, Bernadet Dejonge, Nikki Golden, Kim Brayton, Carrie Steinman, Shannon Raybold

Milne Open Textbooks

Read this book online at: https://milnepublishing.geneseo.edu/social-justice-in-human-services/

Social Justice & Advocacy in Human Services delves into the complex realm of social justice, offering a deep dive into historical roots and theories to practical applications in the field. This text covers fundamental concepts, including power, privilege, and oppression, and explores critical issues like racism, gender, sexuality, poverty, religion, and disability in the context of the United States. The last section of the book hones in on the field of human services, discussing power, privilege, and bias in this context, and lastly exploring equitable distribution, human rights, and the systems and entry points …

Precision Medicine And Beyond: Evolving Roles Of Targeted Therapy, Immunotherapy, And Artificial Intelligence In Oncology, Linwei Li, Anika Doppalapudi, Jennifer Escamilla, Annu Karithara, Christine Pham, Angel Phillip, Sriya Gullapalli, Lois Baldado, Arjun Bellamkonda, Daniela Gonzalez, Amin Ibrahim, David Sta. Maria, Kaitlyn Ybanez, Hugo Zamarron, Shizue Mito

School of Medicine Publications

Precision medicine in oncology is an evolving therapeutic approach that leverages genetic, clinical, and biomarker data to tailor treatments to individual patients. This review explores the three core pillars of modern precision oncology: targeted therapy, immunotherapy, and the integration of artificial intelligence (AI) into clinical practice. Targeted therapies, including monoclonal antibodies and antibody-drug conjugates, selectively inhibit molecular pathways involved in tumor growth. While conventional chemotherapy remains the backbone of treatment and has improved remission rates, its cytotoxic nature limits broader applicability and increases the risk of comorbidities. Immunotherapies, particularly immune checkpoint inhibitors and chimeric antigen receptor T-cell therapies, have transformed …

In Vitro Α-Glucosidase Enzyme Inhibition Activity Test Of Water Extract From Sintok (Cinnamomum Sintoc Blume) Bark, Astrella Amanda Putri Saksono, Inana Ratu Soripada Simanjuntak, Mariana Wahjudi, Marisca Evalina Gondokesumo

Pharmaceutical Sciences and Research

Diabetes mellitus is a condition characterized by elevated blood glucose levels beyond the normal limits. One therapeutic approach for managing diabetes mellitus involves inhibiting the α-glucosidase enzyme, which plays a role in glucose absorption in the body. However, the use of oral antidiabetic drugs from the α-glucosidase inhibitor class often causes gastrointestinal side effects. Therefore, exploring natural materials as alternative treatments is a promising option. In Indonesia, one plant with potential as an alternative treatment is sintok (Cinnamomum sintoc Blume), a member of the Cinnamomum genus, which is widely utilized in traditional medicine for chronic diseases such as …

Gastroprotective Potential Of Medicinal Plant From Central Kalimantan: Sungkai Leaves (Peronema Canescens Jack)-Ultrasonic Assisted Extraction In Rats Induced With Absolute Ethanol, Dilasari Savitri, Elsa Trinovita, Ratna Widayati, Septi Handayani, Sintha Nugrahini

Pharmaceutical Sciences and Research

Peptic ulcer disease is a gastrointestinal disorder associated with significant morbidity and mortality. Enhancing the quality of life of patients with peptic ulcers often involves integrating conventional treatments with complementary alternative therapies. One such alternative therapy is herbal remedies, which local communities have long recognized. Sungkai leaves (Peronema canescens Jack) contain various bioactive components, including flavonoids, alkaloids, saponins, tannins, steroids, and phenolic compounds. This study aimed to assess the gastroprotective properties of sungkai leaf extract (Peronema canescens Jack) by analyzing the average size of gastric lesions in male Wistar rats exposed to absolute ethanol. The research used a …

Humor Subversif Dalam Video Musik Balance Ton Quoi Oleh Angele, Nur Annisa Khalish Zarkasya, Airin Miranda

Multikultura

The phenomenon of the #MeToo and #BalanceTonPorc hashtags became the focus of attention in various parts of the world in 2017. It was first popularized by Alyssa Milano on her Twitter account using the #MeToo hashtag, and later followed by Sandra Muller with #BalanceTonPorc in France. The feminist movement on social media inspired many artists and musicians, including Angèle, a singer from Belgium. She released a song and music video titled "Balance Ton Quoi" (2019), in which she expressed that the activist spirit of feminism resides within her, turning her song into a feminist anthem. The messages conveyed in her …

Life-Course And Biography Of Things: Minangkabau Women's Headgear, Attari Putri Denendra, Irmawati Marwoto

International Review of Humanities Studies

Like men, objects also have a biography or life-course. Both biographies are intertwined, so when someone experiences a new life phase transition in their life-course, it will cause changes in the objects attached to them. This is also supported by the statement that the identity is performative. The headgear as one of the elements used by Minangkabau women also represents the identity of the wearer. This research was conducted in three stages: (1) data collection in the form of old photos and literature of Minangkabau women with headgear in Batipuh, Fort de Kock, and Payakumbuh, (2) data processing by analysis …

Integrating Circulating Tumor Dna Into Clinical Management Of Colorectal Cancer: Practical Implications And Therapeutic Challenges, Nikhil Vojjala, Viktoriya Gibatova, Raj N Shah, Sakshi Singal, Rishab Prabhu, Geetha Krishnamoorthy, Karen Riggins, Nagaishwarya Moka

Faculty, Staff and Students Publications

The American Cancer Society estimates that over 152,000 new cases of colorectal cancer (CRC) were diagnosed in 2024, with more than 105,000 cases affecting the colon and 46,000 involving the rectum. CRC remains the second leading cause of cancer-related deaths in the United States, with an estimated 53,010 deaths in 2024. In the era of precision medicine, which incorporates molecular and environmental information into clinical decision-making, identifying patients harboring a deficiency in Deoxyribonucleic acid (DNA) repair allowed for targeted immunotherapies and significantly reduced CRC-related mortality. A significant advancement in this domain is the application of liquid biopsy, which has emerged …

Systematic Review Of Parkinsonism In Cerebrotendinous Xanthomatosis, Jennifer Hanson, Penelope E Bonnen

Faculty, Staff and Students Publications

Background: Cerebrotendinous Xanthomatosis (CTX) is a rare, inherited metabolic disease caused by pathogenic variants in CYP27A1. The clinical presentation of this progressive disease includes cognitive deficits, ataxia, peripheral neuropathy, and pyramidal signs, as well as bilateral cataracts and tendon xanthomas. In some cases, CTX also includes parkinsonism. The goals of this study are to develop a data source that provides improved characterization and awareness of parkinsonism in CTX.

Methods: We conducted a systematic review of the literature according to PRISMA guidelines to identify all published individuals diagnosed with CTX and parkinsonism. Clinical signs, imaging findings and treatment response to …

Investigation Into Intraocular Pressure Distribution Via Computer Aided Engineering (Cae), Madison Maureen Hinman

Masters Theses

The leading cause for irreversible blindness and vision loss is glaucoma - an eye condition associated with elevated intraocular pressure (IOP). Increased IOP is also seen during other pathological conditions like spaceflight-associated neuro-ocular syndrome (SANS), and non-pathological conditions as when playing a wind instrument. The study aimed to describe the influence of different vitreous cavity size as well as vitreous fluid viscosity on the IOP as measured at the back of the eye on the retina. Improved understanding of eye pressure transmission can aid in a better understanding of eye diseases. The experiment conducted included cavities of varying size and …

Utilization Of Biomass From Kerai Payung Trees And Waste Paper Through Pyrolysis Technology To Support The Zero-Waste Concept, Anggita Putri Indadari, Nurfa Anisa, Asih Budi Santoso

Journal of Mechanical Engineering Science and Technology (JMEST)

Wisnuwardhana University is a private institution with a green campus environment surrounded by Kerai Payung trees. This environment produces organic waste from trees and inorganic waste such as used paper from campus activities. This study aims to achieve zero-waste processing by using pyrolysis technology to process campus waste, ensuring minimal residue. The experimental method involves comparing waste processing outcomes between conventional combustion and pyrolysis, the data was analyzed by comparing the results of pyrolysis with conventional combustion. The results of biochar from the pyrolysis process of used paper, Kerai Payung leaves, and nagging Kerai Payung tree are 76 g, 250 …

Characterization Of Curcumin As A Coating Material For Polymer-Free Stents Interms Of Morphology And Release, Ameliyana R.S.P.A. Yani, Muhammad Kusumawan Herliansyah

Journal of Mechanical Engineering Science and Technology (JMEST)

The use of bare metal stents over the long term often leads to the re-narrowing of blood vessels, prompting a shift to drug-eluting stents (DES). However, the use of polymers in DES has been known to trigger inflammation and thrombosis in the arteries. As an alternative, polymer-free drug-eluting stents (PF-DES) have emerged as a safer option. In this study, curcumin was selected as the primary coating material for PFDES using the electrophoretic deposition method. The effects of varying curcumin concentrations (125 µg/ml, 250 µg/ml, and 500 µg/ml) were examined to understand their impact on deposition morphology, coating weight, chemical bonding …

Impact Of Print Speed And Nozzle Temperature On Tensile Strength Of 3d Printed Abs For Permanent Magnet Turbine Systems, Wirawan Wirawan, Hilmi Iman Firmansyah, Satworo Adiwidodo, Mohammad Sukri Mustapa

Journal of Mechanical Engineering Science and Technology (JMEST)

Operational parameters must be integrated into turbine systems' main components, which are determined by turbine systems' functional requirements. The need for producing component designs more effectively raises the possibility of using additive manufacturing. The study focuses on the optimization of the mechanical properties of the principal components of magnetic turbines manufactured with 3D printers using Acrylonitrile Butadiene Styrene (ABS), by changing the temperature and speed of the nozzle. The approach consisted of modeling a standard test piece in CAD software and producing ABS-based test pieces using a 3D printer with print speeds of 50, 70, 90, and 110 mm/s and …