Digital Commons Network^™

Moderate Coffee And Tea Consumption Is Associated With Slower Cognitive Decline, Stephanie R. Rainey-Smith, Kelsey R. Sewell, Belinda M. Brown, Hamid R. Sohrabi, Ralph N. Martins, Samantha L. Gardener

Research outputs 2022 to 2026

Background: Globally, coffee and tea are consumed extensively, potentially providing neuroprotection through anti-inflammatory and antioxidative stress effects. Objective: This study aimed to investigate associations between coffee and tea intake and cognitive function. Methods: In a longitudinal prospective cohort study, dementia-free (n = 8715; age range 60.0–85.2 years) older adults from the UK Biobank self-reported coffee and tea intake over the previous year; ‘never’, ‘moderate’ (1–3 cups/day), or ‘high’ (≥4 cups/day). Participants completed cognitive assessments at ≥2 timepoints (mean of 9.11 years). Results: Those ‘never’ consuming coffee and ‘moderate’ coffee consumers (β = 0.06, p = 0.005; β = 0.07, p <  0.001, respectively), as well as ‘moderate’ tea consumers and ‘high’ tea consumers (β = 0.06, p = 0.009; β = 0.06, p = 0.003, respectively) had slower fluid intelligence decline. Additionally, those ‘never’ consuming coffee and ‘moderate’ coffee consumers had a slower increase in pairs matching errors (β = −0.05, p = 0.022; β = 0.05, p = 0.013) compared to ‘high’ consumers. Conclusions: ‘Moderate’ coffee, and ‘moderate’ and ‘high’ tea intake may be a protective factor against cognitive decline. Randomized controlled trials are required to establish causal relationships leading to evidence-based recommendations regarding benefits of coffee and tea intake.

Kegamangan Sistem Perlindungan Dan Pengelolaan Lingkungan: Melihat Uu Ciptaker Dari Perspektif Prinsip Non-Regresi, Andri G. Wibisana

Jurnal Hukum & Pembangunan

This article evaluates the Environmental Protection and Management Law (UUPPLH) as amended by the Omnibus Law on Job Creation (UUPPLH-Ciptaker) and its implementing regulations. The evaluation uses the normative framework of the principle of non-regression to assess whether the provisions of the UUPPLH-Ciptaker and its implementing regulations represent a setback compared to the legal conditions prior to the enactment of the Omnibus Law. This paper argues that the changes introduced by the UUPPLH-Ciptaker indicate several regressions in Indonesia’s environmental law, particularly in the following areas: a) the weakening of provisions on Environmental Impact Assessment (AMDAL) and Environmental Management and Monitoring …

Combining Lumipulse P-Tau217 And Aβ42/40 As Confirmatory Tests For Aβ Positivity Prior To Disease-Modifying Therapy, James D. Doecke, Ahmed Chenna, Mintzu Lo, Youssouf Badal, Brandon Yee, Robert Martone, Christos Petropoulos, Christopher J. Fowler, Simon Laws, Stephanie R. Rainey-Smith, Ralph N. Martins, Christopher C. Rowe, Colin L. Masters, John Winslow

Research outputs 2022 to 2026

Introduction: For a blood-based biomarker to be considered a confirmatory test for the detection of abnormal amyloid beta (Aβ) levels, the sensitivity and specificity must be equivalent to that of current cerebrospinal fluid tests. Methods: In the current study we assessed the ability of phosphorylated tau (p-tau)217 and Aβ42/40 from the Lumipulse G p-tau217 and β-amyloid ratio (1-42/1-40) tests, individually and combined, to predict Aβ positron emission tomography status in two sub-cohorts from the Australian Imaging, Biomarkers, and Lifestyle Study of Ageing. Results: Testing an Alzheimer's disease continuum cohort, the area under the curve (AUC), sensitivity, specificity, and accuracy for …

Muscle Creatine Levels And Sprint Performance In Young Adult Vegans And Vegetarians After 7 Days Of Creatine Monohydrate Supplementation, Thomas Christian Bonne, Valentina Arthemalle, Colin Stephen Doherty, Andreas Breenfeldt Andersen, Jacob Bejder, Thomas Ehlers, Henrik Holm-Sørensen, Nikolai Baastrup Nordsborg

Research outputs 2022 to 2026

Athletes use creatine monohydrate (CM) to enhance high-intensity exercise performance by increasing creatine phosphate availability. While CM supplementation is known to raise muscle creatine levels in vegans and vegetarians, its impact on exercise performance remains uncertain. We examined the effects of CM supplementation on muscle creatine content and exercise performance in vegans and vegetarians. In a randomized, double-blind placebo-controlled design, 15 healthy vegans and vegetarians consumed CM (0.3 g/kg/day, n = 7) or placebo (PLA, 0.3 g maltodextrin/kg/day, n = 8) four times a day for 7 days. Before and after supplementation, repeated sprint capacity was determined. Body mass and …

Restricted Social Engagement Is Associated With Depressive Symptoms In Older Chinese Adults: A Nationwide Cross-Sectional Study, Zheng Guo, Yulu Zheng, Yahong Zhu, Huacheng Wang, Jian Geng, Hengrui Liu, Piyong Ma, Lois Balmer, Xingang Li

Research outputs 2022 to 2026

Background and Aims: Social isolation has been linked to depressive symptoms in older adults. Previous studies have shown that greater engagement in social activities is associated with better mental health. However, it remains unclear whether restricted social engagement is related to poorer mental health outcomes. This study examined the association between reduced social activities/networking and the presence of depressive symptoms among community-dwelling older Chinese adults. Methods: During the COVID-19 pandemic, people chose to minimize going out to reduce the risk of infection, creating a natural setting that mimicked a passive intervention of restricted social engagement for community-based individuals. Data were …

Antimicrobial Resistance Of Clostridioides (Clostridium) Difficile In Cambodia, Lengsea Eng, Papanin Putsathit, Su Chen Lim, Jessica M. Chisholm, Deirdre A. Collins, Archie C.A. Clements, Kefyalew Addis Alene, Thomas V. Riley

Research outputs 2022 to 2026

Background/Objectives: Antimicrobial resistance (AMR) remains a major topic of interest in infectious disease management. We studied AMR in Clostridioides difficile isolated in Cambodia. Methods: Agar dilution susceptibility testing was performed according to the CLSI guidelines to determine minimal inhibitory concentrations (MICs) of 10 antimicrobials for 192 isolates of C. difficile from four populations in Cambodia: hospitalised adults, hospitalised children, children from an outpatient department (OPD), and healthy adolescents in the community. Results: Using the CLSI MIC breakpoints for anaerobes and EUCAST breakpoints for C. difficile, all isolates were susceptible to vancomycin, metronidazole, fidaxomicin, and amoxicillin/clavulanic acid, and none were resistant …

Cysteine Oxidation Of A Redox Hub Within Complex I Can Facilitate Electron Transport Chain Supercomplex Formation, Runtai Chen, Seyed Amirhossein Tabatabaei Dakhili, Rokas Gerulskis, Yuan Yuan Zhao, Steven Lockhart, Lusine Tonoyan, Arno G. Siraki, Guocheng Huang, Adam Kinnaird, Darren H. Freed, Shelley D. Minteer, Evangelos D. Michelakis, John R. Ussher

Chemistry Faculty Research & Creative Works

The mitochondrial electron transport chain (ETC) is a four complex unit that could be considered the most essential infrastructure within the mitochondria, as it primarily functions to generate the mitochondrial membrane potential (ΔΨm), which can then be utilized for ATP synthesis or heat production. Another important aspect of ETC function is the generation of mitochondrial reactive oxygen species (mtROS), which are essential physiologic signaling mediators that can be toxic to the cell if their levels become too high. Currently, it remains unresolved how a highly utilized and functioning ETC can sense excessive mtROS generation and adapt, to enhance ΔΨm. Here, …

Comprehensive Review Of In Vitro Approaches For Environmental Heavy Metal Exposure, Manas Warke, Madeline English, Camila Padilla, Lexie Gasco, Wendy Leisner, Rupali Datta, Smitha Rao

Michigan Tech Publications

Heavy metals are ubiquitous environmental pollutants, contaminating air, soil, and water via the erosion of natural deposits, as well as originating from anthropogenic sources, such as agriculture, industries, transportation, and landfills. The increasing utilization of heavy metals over the years, combined with the persistent nature of metals in the environment poses a direct threat to human and environment health. Although regulatory limits have been established for toxic metals, assessing the associated health risks using real-life exposure scenarios remains challenging. In this review, we summarize the development and use of in vitro models based two- and three-dimensional cell culture systems, focusing …

Labor Productivity Losses Across Construction Trades: A Machine Learning Approach, Tamima Elbashbishy, Islam H. El-Adaway

Civil, Architectural and Environmental Engineering Faculty Research & Creative Works

Labor productivity is a major concern in the construction industry. Existing research on construction labor productivity (CLP) within specific trades has produced inconsistent findings due to differences in the factors analyzed. This lack of consistency makes it difficult to identify the most critical drivers of productivity losses across trades. To address this gap, this study adopts a cross-trade analytical approach to systematically identify and evaluate the inefficiencies impacting labor productivity in multiple construction trades. Specifically, the study (1) identified common organizational and project-level inefficiencies that influence labor performance; (2) conducted an expert-based survey to measure the frequency and perceived impact …

Khaled Hosseini’S Judgment In The Kite Runner Towards Pashtun And Hazara Identities, Bilal Waziri, Dawod Mangal, Kamaldeen Kamal

Journal of Research Initiatives

This book review offers a compelling examination of Khaled Hosseini's portrayal of Pashtun and Hazara identities in his acclaimed novel, *The Kite Runner*. Through a literary-ethnographic lens, the research delves into how narrative techniques can construct, amplify, or distort ethnic representations, particularly within the tumultuous backdrop of Afghanistan. The novel is scrutinized for its stark depiction of Pashtuns as oppressors and Hazaras as perennial victims, which risks perpetuating a simplistic and problematic singular narrative. Employing a library-based qualitative approach, this paper thoughtfully interprets textual evidence within the rich sociocultural and historical landscape of Afghanistan. The findings reveal that while the …

Society Of Vascular And Interventional Neurology (Svin) Stroke Interventional Laboratory Consensus (Silc) Criteria For Training Standards And Maintenance Of Certification In Neurointervention, Ossama Y. Mansour, Kaiz S. Asif, Roberta Novakovic-White, Boris Pabon, Santiago Ortega-Gutierrez, Atilla Ozcan Ozdemar, Alicia Castonguay, Brijesh Mehta, Dileep R. Yavagal, Ameer E. Hassan

School of Medicine Publications

The global shortage of neurointerventionalists presents a challenge to timely stroke care, particularly in low‐ and middle‐income countries. The Society of Vascular and Interventional Neurology Stroke Interventional Laboratory Consensus criteria aim to standardize training and certification in neurointervention to address these disparities. This white paper reviews existing training standards in various regions, identifies gaps, and proposes a structured framework encompassing entry requirements, program structure, and certification processes. The Stroke Interventional Laboratory Consensus criteria further outline requirements for training centers and program directors. By establishing global standards, the Stroke Interventional Laboratory Consensus criteria seek to improve patient outcomes and expand access …

Gene Expression Of Anthocyanin Pigments In The California Native Plant Leptosiphon Parviflorus: Interactions Between Flower Color Morphology And Abiotic Stressors, Weston Gonor

Master's Theses

For plants to survive in harsh conditions imposed by abiotic stressors, they must develop mechanisms of adaptation. One of the common types of adaptation seen in plants is the production of anthocyanin pigments, which have been shown to protect plants from UV radiation, metabolic stress, and drought. In this study, we used the flower color polymorphic species Leptosiphon parviflorus to investigate the role of anthocyanin pigments in protecting plants from abiotic stress. To accomplish this, RNA samples were taken from flower, leaf and root tissue of different flower color morphs of Leptosiphon parviflorus (Polemoniaceae) grown in high magnesium and water …

Alpine Plants And Climate Change: Tracking Community Shifts In Yosemite National, Brooke L. Wallasch

Master's Theses

As climate change progresses, alpine plant communities are predicted to shift upslope as they track temperature over time. Relative to lowland environments, alpine areas are experiencing a faster rate of temperature change due to a phenomenon referred to as elevation-dependent warming. A common approach for tracking plant communities shifts over time, is to conduct resurveys of the same area at several time points, as the Global Observational Research Initiative in Alpine Environments (GLORIA) has done on mountain summits around the world since 2001. In 2011-2013, GLORIA developed a supplemental survey method whereby belt transects were established downslope of summits in …

Navigating Hepatitis C Care, Cheyenne R. Wagi, Renee Mcdowell, Anyssa Wright, Kathleen L. Egan, Christina S. Meade, April M. Young, Madison N. Enderle, Angela T. Estadt, Kathryn E. Lancaster

Epidemiology and Environmental Health Faculty Publications

Background Hepatitis C virus (HCV) and injection drug use among young women are dramatically rising in the rural United States. From 2004 to 2017, heroin use among non-pregnant women increased 22.4% biennially, mirroring increases in HCV cases, especially among younger populations. Young women who inject drugs (YWID, ages 18–35) face elevated HCV risk due to biological, behavioral, and socio-cultural factors. Barriers to HCV testing and treatment services further delay diagnoses, fuel transmission, and limit access to harm reduction services. This study applies the Theoretical Domains Framework (TDF) to identify factors influencing HCV testing and treatment among YWID in rural Appalachia …

Alpine Plants And Climate Change: Tracking Community Shifts In Yosemite National Park, Brooke Wallasch, Annalise Burrows, Madeleine Colbert, Michael Gottlieb, Ty Connelly, Julian Durante, Emily Staats, Marjorie Say

Baker/Koob Endowments Awarded Projects

As climate change progresses, alpine plant communities are predicted to shift upslope as they track temperature over time. Relative to lowland environments, alpine areas are experiencing a faster rate of temperature change due to a phenomenon referred to as elevation-dependent warming. A common approach for tracking plant communities shifts over time, is to conduct resurveys of the same area at several time points, as the Global Observational Research Initiative in Alpine Environments (GLORIA) has done on mountain summits around the world since 2001. In 2011-2013, GLORIA developed a supplemental survey method whereby belt transects were established downslope of summits in …

Towards The Systematic Cross-Civilizational Comparison: How Civilizations Work - Case 1: The Monotheistic Civilization, Liah Greenfeld

Comparative Civilizations Review

The purpose of this essay is to offer several hypotheses based on the concept of civilization and the conceptual scaffolding for the study of the cultural reality, proposed in the Spring 2024 CCR paper, regarding the three civilizations coexisting in the world today: the monotheistic, the Sinic, and the Indic. It introduces the modal dimensions along which civilizations may differ on the level of the individual mind — cognitive (pertaining both to the structure and contents of thought), moral, and emotional; and that of the society (separate institutions and institutional systems) and history.

Books Of Interest Fall 2025, Stephen T. Satkiewicz

Comparative Civilizations Review

Books that may be of interest to scholars of the comparative study of civilizations, and may add significantly to the body of scholarship in the civilizational field. These books are also available for book reviews in future editions of Comparative Civilizations Review.

Opioid Withdrawal Treatment: Buprenorphine/Naloxone (Suboxone), Children's Mercy Kansas City

Clinical Pathways

No abstract provided.

Ontology Accelerates Few-Shot Learning Capability Of Large Language Model: A Study In Extraction Of Drug Efficacy In A Rare Pediatric Epilepsy, Pedram Golnari, Katrina Prantzalos, Veronica Hood, Mary Anne Meskis, Lori L Isom, Karen Wilcox, Jack M Parent, Dennis Lal, Samden D Lhatoo, Howard P Goodkin, Elaine C Wirrell, Kelly G Knupp, Manisha Patel, Jeffrey A Loeb, Joseph E Sullivan, Lauren Harte-Hargrove, Brandy E Fureman, Jeffrey Buchhalter, Satya S Sahoo

Faculty, Staff and Student Publications

OBJECTIVE: Dravet Syndrome (DS) is a developmental and epileptic encephalopathy that is characterized by severe, prolonged motor seizures and high resistance to multiple antiseizure medications (ASMs) with multiple comorbidities. Evaluating the efficacy of new drugs in DS preclinical models and mapping them to human phenotypes of DS through analysis of published literature is an important goal for improving outcomes in this rare pediatric epilepsy.

MATERIALS AND METHODS: Large language models (LLM) have demonstrated great promise in parsing published literature; however, the performance of LLMs falls short in medical applications. In this study, we investigate the effectiveness of domain ontology developed …

(Re)Birth Of A Nation: Reconstruction’S Unfinished Business, Zanita E. Fenton

Michigan Journal of Race and Law

The irony, alluding to the title of the 1915 silent movie Birth of a Nation, seeks to make conspicuous the counter-stories that more authentically account for the “birth” and development of American society. Ku Klux Klan-sponsored propaganda designed to evoke hyper-racist fearmongering and perpetuate sexual paternalism over White women, the plot from Birth of a Nation reflects the paradigmatic race-bait: relentless pursuit of a White woman by a Black man. This storyline was fictionalized, culturally unrealistic and deliberately omitted the very real sexual exploitation of Black women and girls. Birth of a Nation parallels Constitutional history that marginalizes supplemental …

Multi-Fidelity Machine Learning Modeling For Aerodynamic Response Prediction Of Aerospace Vehicles, Ethan S. Jackman

Theses and Dissertations

Hypersonic vehicle design requires understanding complex aerodynamic phenomena across the full flight regime. This study presents a novel MF surrogate modeling methodology that enables the prediction the full field response across a vehicle’s surface. A Space-Filling Curve (SFC) is used to convert unstructured data into 1D vectors. The a Convolutional Autoencoder is used with transfer learning to reduce the dimensionality of the data. An Emulator-Embedded Neural Network (E2NN) combines multi-fidelity data for fast, accurate predictions. A benchmark analytical example and hypersonic application are used to evaluate the methodology. Using various numbers of samples and sampling strategies it is found that …

Minimal Risk Animal Research And Education Ethics Application Form, Munster Technological University, Ireland

Policies & Procedures Documents

Researchers and educators are required to ensure that no direct interaction with animals, i.e., interaction beyond the ethics screening level, will be initiated until Animal Research and Education Ethics Committee (AREEC) approval is received. Depending on the nature of the study described below, the study may require a preliminary review by the AREEC Chairperson and may be subject to further clarification. Please note that all questions requiring either a ‘yes’ or ‘no’ answer must be completed –if you fail to do so, or leave them blank, your form will be returned.

This form is applicable to university researchers and educators.

Full Ethical Review Animal Research Education And Ethics Application Form, Munster Technological University, Ireland

Policies & Procedures Documents

Researchers and educators are required to ensure that no direct interaction with animals, i.e., interaction beyond the ethics screening level, will be initiated until Animal Research and Education Ethics Committee (AREEC) approval is received. Depending on the nature of the study described below, the study may require a preliminary review by the AREEC Chairperson and may be subject to further clarification. Please note that all questions requiring either a ‘yes’ or ‘no’ answer must be completed –if you fail to do so, or leave them blank, your form will be returned.

This form is applicable to university researchers and educators.

Animal Research And Education Ethics Committee Terms Of Reference, Munster Technological University, Ireland

Policies & Procedures Documents

The University’s Animal Research and Education Ethics Committee (AREEC) facilitates the statutory required formal ethical review of all research and educational activities that involve animals as subjects considered sentient beings prior to commencement of the study. Researchers and educators are also required to liaise with the Animal Welfare Body (AWB) in respect of animal interactions. The AWB manages the wider context of animal welfare in accordance with Animal Welfare legislation.

Antibacterial And Anticancer Properties Of Zinc Oxide Nanoparticles: A Review Of Current Advances And Future Directions, Ali Hadi, Uday Nayef, Falah Mutlak, Majid Jabir, Mohammed Muayad

Journal of Applied Sciences and Nanotechnology

Zinc oxide Nanoparticles (ZnO-NPs) have a promising potential in antibacterial and anticancer treatments because of their ease of production, low toxicity, and versatility in application. This review encompasses recently developed synthesis, characterizing and biomedical applications of ZnO-NPs. Green synthesis methodologies, sol-gel, and precipitation influence the biological effectiveness of ZnO-NPs, these methods particularly affect key characteristics such as particle size, shape and surface charge. These properties play crucial roles in antibacterial effectiveness, which facilitates their ability to generate reactive oxygen species (ROS) and bacterial cell membrane disruption, leading to bacterial cell death. The efficiency of ZnO-NP in cancer treatment is also …

Understanding Long Covid In National Community-Based Cohort: Symptom Clusters, Symptom Natural History, And Vaccine’S Role As A Prevention Tool, Yanhan Shen

Dissertations and Theses

BACKGROUND: Long COVID, or post-acute sequelae of SARS-CoV-2 infection (PASC), represents a growing public health concern with diverse symptom profiles, unclear risk factors, and evolving evidence on potential prevention strategies. Most studies of Long COVID have relied on electronic health records or convenience samples, which may underestimate mild or community-based cases and lack standardized follow-up, and often do not include pre-infection health information or complete infection histories. This dissertation leverages prospective data from a national community-based cohort to characterize the heterogeneity of Long COVID symptoms, assess symptom trajectories over time, and evaluate the effect of COVID-19 third dose vaccination on …

The First Complete Assembly For A Lungless Urodelan With A “Miniaturized” Genome, The Northern Dusky Salamander (Plethodontidae: Desmognathus Fuscus), Edward A. Myers, Alexander A. Stewart, Aidan E. O’Brien, Jeramiah J. Smith, R. Alexander Pyron

Biology Faculty Publications

Salamanders have some of the largest genomes among animals, driven primarily by expansion of repeat elements and slow rates of DNA loss. However, species in the lungless genus Desmognathus (Plethodontidae) have some of the smallest genomes at ∼13 to 15 GB, though previous sequencing attempts with short-read assemblies were still fragmentary. Here, we assemble an annotated draft genome of Desmognathus fuscus using PacBio HiFi reads and transcriptomic data from 2 specimens from the same population. The combined dataset resulted in a 16.1 GB assembly in 19,632 contigs and an L/N50 of 2,459/1.74 MB, with the longest contig at 27.9 MB. …

Lsab Minutes September 2025, Shawna Battle, Maryke Barber

WRL: Library Student Advisory Board Minutes

No abstract provided.

Estimating Historical Age-Sex Distributions Of A Tribal Population: A Case Study Of The Hopi, 1900 To 1940, David Swanson, Jeff Tayman

Publications, Reports and Presentations

Historical information on tribal populations in the United States is scattered and discontinuous. A significant part of the discontinuity is the gap between 1900 and 1970. This paper describes a process that may partially fill this gap by developing decennial age-sex data from 1900 to 1940. Where temporally consistent, we compare these estimates to those done by others. This work provides a point of departure for generating more demographic information about the Hopi from 1900 to 1940 and, ultimately, beyond 1970, a critical turning point regarding the increased availability of American Indian data from the U.S. Census Bureau. It also …

I Am Scared Too: A Qualitative Study On The Influential Factors On The Fear Of Childbirth In Black Women, Imani Rivers

Tennessee State University Alumni Theses and Dissertations

Pregnancy and childbirth can evoke a range of emotions, including happiness, frustration, and fear. While some worry during pregnancy is expected, heightened and persistent fear can negatively impact a woman’s mental and physical health. Despite this, fear of childbirth remains underexplored, particularly in the context of Black women’s experiences. Existing literature lacks focus on the contextual and systemic factors contributing to this fear, creating a significant research gap (Reissig et al., 2021). Black women in the United States are disproportionately affected by medical mistreatment, often experiencing dismissal and silencing in clinical settings—an issue frequently rooted in implicit bias and racial …