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Mitochondrial Insoluble Aggregates In Aging And Alzheimer’S Disease Models: Cross-Species Proteomic Integration, Identification Of Conserved Candidates, And Pharmacological Disruption Of Eef-2 Interactions, Sonu Pahal Dec 2025

Mitochondrial Insoluble Aggregates In Aging And Alzheimer’S Disease Models: Cross-Species Proteomic Integration, Identification Of Conserved Candidates, And Pharmacological Disruption Of Eef-2 Interactions, Sonu Pahal

Theses and Dissertations

Protein aggregation within mitochondria emerges early in both aging and Alzheimer’s disease (AD) and contributes to progressive loss of proteostasis. Insoluble mitochondrial aggregate fractions from Caenorhabditis elegans revealed extensive enrichment of metabolic and translational proteins that also appear in human Alzheimer hippocampal aggregates. Comparative analysis across age and genotype identified a conserved subset of aggregation-prone proteins, several of which cluster around elongation factor 2 (eEF-2), a regulator of ribosomal translocation and energy coupling. Cross-species integration defined a network in which eEF-2 links chaperones, metabolic enzymes, and RNA-binding proteins that co-aggregate in both human Alzheimer material and nematode models. Functional tests …

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Improving Skin Cancer Knowledge And Screening Among Older Chinese Americans Males, Yan Wang, Anne Derouin, Barbara Turner, Hanzhang Xu Dec 2025

Improving Skin Cancer Knowledge And Screening Among Older Chinese Americans Males, Yan Wang, Anne Derouin, Barbara Turner, Hanzhang Xu

Biennial Convention (CONV)

Skin cancer is the most common cancer in the U.S. with more than 5 million cases diagnosed annually. It is estimated that about 1 in 5 Americans will develop skin cancer by the age of 70, a prevalence that has been increasing annually (Adams et al., 2021; Aggarwal et al., 2021; Dildar et al., 2021; Trager et al., 2022). As reported by the ACS, men are more likely to develop melanoma compared to women. At the age of 80, men are three times more likely to develop melanoma than women, nearly double the number of male deaths due to the …

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Space Agriculture: A Comprehensive Systems-Level Review Of Challenges And Opportunities, Hassan Fazayeli, Aaron Lee M. Daigh, Cassandra Palmer, Santosh Pitla, David Jones, Yufeng Ge Dec 2025

Space Agriculture: A Comprehensive Systems-Level Review Of Challenges And Opportunities, Hassan Fazayeli, Aaron Lee M. Daigh, Cassandra Palmer, Santosh Pitla, David Jones, Yufeng Ge

Biological Engineering Faculty Publications

As humanity prepares for prolonged space missions and future extraterrestrial settlements, developing reliable and resilient food-production systems is becoming a critical priority. Space agriculture, the cultivation of plants beyond Earth (particularly on the Moon and Mars), faces a constellation of interdependent environmental, biological, and engineering challenges. These include limited solar radiation, elevated ionizing radiation, large thermal variability, non-Earth atmospheric pressures, reduced gravity, regolith substrates with low nutrient-holding capacity, high-CO2/low-O2 atmospheres, pervasive dust, constrained water and nutrient availability, altered plant physiology, and the overarching need for closed-loop, resource-efficient systems. These stressors create an exceptionally challenging environment for plant …

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Polycystin-2 Is Cardioprotective Against Myocardial Infarction By Regulating The Calcium-Mediated Er-Stress Response, Virdjinija Vuchkovska Dec 2025

Polycystin-2 Is Cardioprotective Against Myocardial Infarction By Regulating The Calcium-Mediated Er-Stress Response, Virdjinija Vuchkovska

Dissertations

Patients with autosomal polycystic kidney disease (ADPKD) have an increased risk and worse outcomes after acute myocardial infarction, but the mechanism for this is unknown. Polycystin 2 (PC2), one of the two main proteins mutated in ADPKD, is a calcium permeant channel that localizes to the ER/SR. In non-cardiac cells, PC2 regulates the unfolded protein response (UPR) pathway under ER stress. However, whether PC2 is cardioprotective against ER stress is unknown. We found that PC2 expression increased in cardiomyocytes from human ischemic hearts and infarcted murine hearts. Cardiomyocyte-specific PC2 KO (PC2 KO) mice had worsened cardiac function after myocardial infarction …

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Using Light To Dissect Mechanisms Of Septin Recruitment, Shreya Chandrasekar Dec 2025

Using Light To Dissect Mechanisms Of Septin Recruitment, Shreya Chandrasekar

Dissertations

Cells interpret biochemical and mechanical signals through dynamic regulation of the cytoskeleton and adhesion complexes, enabling key processes such as shape adaptation, force generation and migration. As these signals vary in both time and space, they can be challenging to resolve using traditional bulk assays. To overcome this limitation, we employ light-based optogenetic tools to reversibly modulate biochemical signals and mechanical equilibrium within cells. Specifically, we use the iLID optogenetic approach to locally activate signaling and manipulate contractility within the cytoskeleton for the purpose of investigating the role of RhoA and contractility on septin organization and adhesion protein localization. We …

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Wf-2453 Post-Wildfire Hydrogeomorphic Risk Management Assessment, Belize A. Lane Dec 2025

Wf-2453 Post-Wildfire Hydrogeomorphic Risk Management Assessment, Belize A. Lane

Funded Research Records

No abstract provided.

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Collaborative Research: Cif: Medium: Foundations Of Robust Deep Learning Via Data Geometry And Dyadic Structure, Kevin Moon Dec 2025

Collaborative Research: Cif: Medium: Foundations Of Robust Deep Learning Via Data Geometry And Dyadic Structure, Kevin Moon

Funded Research Records

No abstract provided.

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Collaborative Research: Seed-Fungal Interactions: Uncovering Functional Specificity And Primary Symbionts As Key Drivers Of Tropical Tree Recruitment, Noelle Beckman Dec 2025

Collaborative Research: Seed-Fungal Interactions: Uncovering Functional Specificity And Primary Symbionts As Key Drivers Of Tropical Tree Recruitment, Noelle Beckman

Funded Research Records

No abstract provided.

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Exploration Of The Microbiome Of Native Plants For Plant Growth-Promoting Microbes To Mitigate Effects Of Abiotic Stresses In Crop Plants, Amita Kaundal Dec 2025

Exploration Of The Microbiome Of Native Plants For Plant Growth-Promoting Microbes To Mitigate Effects Of Abiotic Stresses In Crop Plants, Amita Kaundal

Funded Research Records

No abstract provided.

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Harnessing Blueberry Flower Chemistry And Morphology To Boost Pollination And Bee Health, Monica Borghi Dec 2025

Harnessing Blueberry Flower Chemistry And Morphology To Boost Pollination And Bee Health, Monica Borghi

Funded Research Records

No abstract provided.

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Intouch Week Of December 8, 2025, New York Medical College Dec 2025

Intouch Week Of December 8, 2025, New York Medical College

InTouch

No abstract provided.

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Elephant In The Classroom: How Ethical Ai Can Improve Student Success, Ibrahim Kocaman, Daniel A. Cutrer Dec 2025

Elephant In The Classroom: How Ethical Ai Can Improve Student Success, Ibrahim Kocaman, Daniel A. Cutrer

Publications

The integration of artificial intelligence (AI) into teaching and learning in higher education without compromising academic integrity is a pressing issue. To make the benefits of generative AI (GenAI) available to students while upholding principles of ethics and academic honesty, the authors implemented an ethical use of AI policy in their Introduction to Research Methods at Embry-Riddle University. The authors hypothesized and found that allowing ethical utilization of AI would lead to higher student engagement and academic success. These findings offer valuable insights for higher education programs and educators, particularly in security studies.

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Thriving Hives: The Apiary - Beekeeping Essentials, Joseph Okoh, Andree' Walker Bravo Dec 2025

Thriving Hives: The Apiary - Beekeeping Essentials, Joseph Okoh, Andree' Walker Bravo

All Current Publications

This fact sheet is designed to help honey bee producers optimize their beekeeping practices and improve management systems. It offers essential guidance on selecting an ideal apiary location, choosing the right beehive, and ensuring efficient colony management. Additionally, this document serves as a valuable training resource for aspiring beekeepers.

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Artificial Intelligence: A Double-Edged Sword In Support And Subversion Of The Biological Weapons Convention; Part One: Framing The Issues, Elise Annett, Diane Dieuliis, James Giordano Dec 2025

Artificial Intelligence: A Double-Edged Sword In Support And Subversion Of The Biological Weapons Convention; Part One: Framing The Issues, Elise Annett, Diane Dieuliis, James Giordano

Strategic Insights

This commentary explores how artificial intelligence (AI) is profoundly affecting the biological enterprise, serving both as a powerful tool for scientific advancement and as a potential vector for misuse. The authors explain that AI can accelerate research, improve diagnostics, and enhance biodefense, but it also lowers barriers to creating or modifying biological agents and can be exploited for harmful ends. The dual effects make AI a "double-edged sword" that challenges existing governance, detection systems, and deterrence frameworks in biosecurity. Responsible integration of AI into biology requires policies that balance innovating with safeguards, strengthened international cooperation, and adaptive oversights to ensure …

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Investigation Of Coral Reefs For Coastal Protection: Hydrodynamic Insights And Sustainable Flow Energy Reduction, Faisal Karim, Napayalage A. K. Nandasena, James P. Terry, Mohamed M. Mohamed, Zhonghou Xu Dec 2025

Investigation Of Coral Reefs For Coastal Protection: Hydrodynamic Insights And Sustainable Flow Energy Reduction, Faisal Karim, Napayalage A. K. Nandasena, James P. Terry, Mohamed M. Mohamed, Zhonghou Xu

All Works

Coral reefs are integral components of tropical coastal marine ecosystems that have considerable capacity to mitigate extreme flows and marine floods caused by storms and tsunamis. However, limited studies on coral reef efficacy in reducing such flows, coupled with variable roughness coefficient characteristics, hinder their broader utilization in sustainable engineering applications for societal benefit. In this study, we conducted comprehensive experimental investigations to examine flow–coral interactions and the flow energy reduction capabilities of coral reefs. Three-dimensional-printed coral reefs were used to simulate actual coral reefs, providing a scalable and environmentally responsible approach for studying nature-based coastal protection systems. Flow characteristics …

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Engineered Multifunctional Drug-Loaded Dendrimer Nanoparticles For Glaucoma: Triple Mechanism Via Antioxidant Activity, Iron Chelation, And Enhanced Ocular Transport, Burhan Ates, Ashish Trital, Vimalin Jeyalatha Mani, Lei Xu, Jonathan Kenlee, Nuran Ercal, Hu Yang Dec 2025

Engineered Multifunctional Drug-Loaded Dendrimer Nanoparticles For Glaucoma: Triple Mechanism Via Antioxidant Activity, Iron Chelation, And Enhanced Ocular Transport, Burhan Ates, Ashish Trital, Vimalin Jeyalatha Mani, Lei Xu, Jonathan Kenlee, Nuran Ercal, Hu Yang

Chemistry Faculty Research & Creative Works

In this study, we developed multifunctional nanoparticles based on polyamidoamine (PAMAM) dendrimers functionalized with caffeic acid (CA) and poly (ethylene glycol) maleimide (PEGM) for the topical delivery of hydrophobic antiglaucoma drugs brimonidine (BM) and betaxolol (BX). The PAMAM-CA and PAMAM-CA-PEGM conjugates exhibited antioxidant and iron-chelating activities in a dose-dependent manner. BM- and BX-loaded dendrimer nanoparticles produced using a multi-inlet vortex mixer showed uniform spherical morphology (∼80 nm by TEM) and hydrated sizes of ∼135-144 nm by DLS. Both nano formulations demonstrated high cytocompatibility with human corneal epithelial cells and were nonirritant in the HET-CAM assay, with PEGM further improving cytocompatibility. …

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Time-Resolved Ultrafast Infrared Spectroscopic Interrogation Of Intramolecular Reaction Coordinates, Valerie Winkler Dec 2025

Time-Resolved Ultrafast Infrared Spectroscopic Interrogation Of Intramolecular Reaction Coordinates, Valerie Winkler

Arts & Sciences Graduate Student Theses and Dissertations

Light-induced chemical transformations are practical across many chemical and biological systems. From intramolecular hydrogen-bonding coordinates to reactions which alter the carbon framework of a molecule, the application of light can induce conformational changes that can subsequently be harnessed for a variety of tasks. However, molecular-level mechanistic insight about photo-induced chemical reactions remains difficult to acquire using current methodologies. In this dissertation, several intramolecular reactions are investigated and characterized, ranging from ground- and excited-state intramolecular proton transfers to the photochemical synthesis of a complex organic cyclization structure. The reaction coordinates are directly interrogated by utilizing ultrafast infrared spectroscopic techniques, such as …

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2025-05 May Newsletter, Sammi Williams Dec 2025

2025-05 May Newsletter, Sammi Williams

NMOER Newsletters

No abstract provided.

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2025-03 March Newsletter, Sammi Williams Dec 2025

2025-03 March Newsletter, Sammi Williams

NMOER Newsletters

No abstract provided.

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Imaging Reactive Oxygen Species With L-012 Reveals Neutrophil Extracellular Trap Formation In Pancreatic Ductal Adenocarcinoma, Angisha Basnet, Kaitlyn M Landreth, Michael Sestito, Kristen Ranson, Seth T Gammon, Brian A Boone Dec 2025

Imaging Reactive Oxygen Species With L-012 Reveals Neutrophil Extracellular Trap Formation In Pancreatic Ductal Adenocarcinoma, Angisha Basnet, Kaitlyn M Landreth, Michael Sestito, Kristen Ranson, Seth T Gammon, Brian A Boone

Faculty, Staff and Student Publications

Neutrophils, key effector cells of the innate immune system, combat pathogens through mechanisms including the production of reactive oxygen species (ROS) and the release of neutrophil extracellular traps (NETs). While these responses are critical for host defense, prolonged elevation of ROS and dysregulated NETosis mediated by neutrophils have been implicated in autoimmune diseases, chronic inflammation, and cancer. In pancreatic ductal adenocarcinoma (PDAC), a highly aggressive and inflammatory malignancy, an increase in neutrophils infiltrating the tumor microenvironment promotes cancer progression and metastasis through increased ROS production and NET release. Using bioluminescence imaging with the reporter L-012 and NET assays, we assessed …

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Update To: New Butterfly Taxa And Findings From Genomic Analyses, Jing Zhang, Qian Cong, Jinhui Shen, Leina Song, Nick V. Grishin Dec 2025

Update To: New Butterfly Taxa And Findings From Genomic Analyses, Jing Zhang, Qian Cong, Jinhui Shen, Leina Song, Nick V. Grishin

The Taxonomic Report of the International Lepidoptera Survey

Due to the United States government shutdown, GenBank services were unavailable, and accession numbers could not be obtained for the sequences reported in the original publication. This update provides the GenBank accession numbers for these sequences, together with additional taxonomic findings accumulated since the initial study. One genus, 16 species and four subspecies are proposed as new (type species or localities in parentheses): Madaga Grishin, gen. n. (Artitropa alaotrana Oberthür, 1916), Udranomia eurianus Grishin, sp. n. (Ecuador: Napo), Entheus dalina Grishin, sp. n. (Brazil: Pará), Entheus ambo Grishin, sp. n. (Colombia: Cauca), Entheus pico Grishin, sp. n. (Colombia: Valle …

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Mechanistic Modelling And Parameter Estimation Of Heterogeneous Catalytic Synthesis Of Green Fuel, Rasheed U. Owolabi, Obinna P. Anele, Mohammed A. Usman Dec 2025

Mechanistic Modelling And Parameter Estimation Of Heterogeneous Catalytic Synthesis Of Green Fuel, Rasheed U. Owolabi, Obinna P. Anele, Mohammed A. Usman

Mansoura Engineering Journal

Investigation of the kinetics and mechanistic modelling of biodiesel synthesis through the reaction of castor oil with methanol under catalyzed conditions was carried out in this study. The reaction mechanisms of the Eley-Rideal, Langmuir-Hinshelwood-Hougen-Watson, and Hattori type were employed to identify the rate-determining or controlling step of the reaction. Thirteen rate expressions were developed for reactant adsorption, product desorption, and surface chemical reactions. The experimental data from Sanchez-Cantu et al. were used to validate the models, and the best-fitting model and parameter estimation were evaluated using SAS and MATLAB software. From the results, the Eley-Rideal mechanism with glycerol desorption as …

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Artem-Is For Erp: Agreed Reporting Template For Eeg Methodology-International Standard For Event-Related Potential Experiments, Giorgio Ganis Dec 2025

Artem-Is For Erp: Agreed Reporting Template For Eeg Methodology-International Standard For Event-Related Potential Experiments, Giorgio Ganis

School of Psychology

The choices we make during the recording, preprocessing and analysis of event-related potentials (ERP) data can affect study outcomes. As such, it is critical that they are transparently reported to allow for reproducibility. Yet, systematic reviews of reporting practices in the field have shown that journal articles often do not meet this goal and that existing reporting guidelines have not resulted in a sufficient improvement in reporting transparency. An easier workflow for transparently documenting pipelines used in regular journal articles is needed. The ARTEM-IS (Agreed Reporting Template for EEG Methodology—International Standard) initiative is working towards addressing this issue by building …

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Myocardial Lipin1 Protects The Heart Against Ischemic Injury By Preserving Lipid Homeostasis, Jiaxi Guo, Brian N. Finck, Et Al. Dec 2025

Myocardial Lipin1 Protects The Heart Against Ischemic Injury By Preserving Lipid Homeostasis, Jiaxi Guo, Brian N. Finck, Et Al.

2020-Current year OA Pubs

Impaired cardiac lipid metabolism has been reported to cause heart failure. Lipin1, a multifunctional protein, is a phosphatidate phosphatase that generates diacylglycerol from phosphatidic acid and a transcriptional cofactor that regulates lipid metabolism-related gene expression. Here, we investigated the roles of lipin1 in cardiac remodeling after myocardial infarction (MI). The expression levels of lipin1 significantly decreased in cardiomyocytes of the human failing heart and murine ischemic myocardium. Cardiomyocyte-specific Lpin1 knockout (cKO) mice showed left ventricle enlargement and reduced fractional shortening after MI, compared with control mice. This was accompanied by elevated cardiac fibrosis, accumulation of reactive oxygen species, and increased …

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Gastrectomy Promoted Diabetes Remission Involves The Molecular Clock And Epigenetic Mechanisms In A Rat Model Of Lean Type 2 Diabetes., Aurélie Le Lay, François Brial, Claude Rouch, Xiaojian Shao, Mathieu Bourgey, Kazuhiro Sonomura, Huiting Ou, Sara Ghezzal, Mylène Vincent, Marylène Rugard, Karine Audouze, Jiannis Ragoussis, Fumihiko Matsuda, Guillaume Bourque, Elin Grundberg, Mark Lathrop, Christophe Magnan, Dominique Gauguier Dec 2025

Gastrectomy Promoted Diabetes Remission Involves The Molecular Clock And Epigenetic Mechanisms In A Rat Model Of Lean Type 2 Diabetes., Aurélie Le Lay, François Brial, Claude Rouch, Xiaojian Shao, Mathieu Bourgey, Kazuhiro Sonomura, Huiting Ou, Sara Ghezzal, Mylène Vincent, Marylène Rugard, Karine Audouze, Jiannis Ragoussis, Fumihiko Matsuda, Guillaume Bourque, Elin Grundberg, Mark Lathrop, Christophe Magnan, Dominique Gauguier

Manuscripts, Articles, Book Chapters and Other Papers

Bariatric surgery results in type 2 diabetes (T2D) improvement. To identify mechanisms associated with gastrectomy-promoted T2D remission in lean individuals, we performed pathophysiological, behavioural and molecular (liver transcriptome, metabolome and lipidome) investigations in the Goto-Kakizaki (GK) model of spontaneously-occurring non-obese T2D following vertical sleeve gastrectomy (VSG) or sham operation. VSG resulted in sustained reduction in hyperglycemia and changes in nycthemeral feeding patterns and activity. Liver transcriptome and lipidome profiling pointed to changes in the expression of genes involved in inflammation, PPAR signalling and fatty acid metabolism, and in the regulation of phosphatidylcholine and lysophosphatidylethanolamine classes. Deeper analysis revealed altered expression …

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Spike Timing Depended Plasticity Produces Unsupervised Learning Of Synergistic Muscle Feedback In A Synthetical Neural Network, Mark Allen Pupkiewicz Dec 2025

Spike Timing Depended Plasticity Produces Unsupervised Learning Of Synergistic Muscle Feedback In A Synthetical Neural Network, Mark Allen Pupkiewicz

Dissertations and Theses

This study investigates how type Ia feedback from muscle spindles can be organized into groups representing agonistic muscle pairs through Spike Timing Dependent Plasticity (STDP). A single degree of freedom joint is actuated with four biologically modeled muscles forming two agonistic pairs. In order to emulate the sensory dynamics of biological muscle spindles, sensors in the model record the active length and velocity states of each muscle, the two primary factors eliciting type Ia afferent responses. In biological networks, synapses from Ia sensory neurons frequently activate interneurons representing agonistic muscle sources. This research investigates whether this organization can emerge in …

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You Have To Cut&Walk Before You Can Cut&Run: Regulation Of Gene Expression By The Vitamin D Receptor (Vdr) In The Annual Killifish, Austrofundulus Limnaeus, Rosalia Tanori Dec 2025

You Have To Cut&Walk; Before You Can Cut&Run;: Regulation Of Gene Expression By The Vitamin D Receptor (Vdr) In The Annual Killifish, Austrofundulus Limnaeus, Rosalia Tanori

Dissertations and Theses

The annual killifish, Austrofundulus limnaeus, found in ephemeral ponds in South America, possesses a remarkable ability to survive extended periods without water and oxygen. This ability is associated with developmental dormancy known as diapause. Numerous genetic and environmental factors influence the entry into diapause and tolerance to environmental stress. Among these is vitamin D3 signaling mediated by the vitamin D receptor (VDR), which plays a crucial role in regulating entry into diapause and the continuous development of an embryo in a temperature-dependent manner. Vitamin D3 signaling influences a variety of physiological processes in vertebrates. While extensively characterized in mammalian …

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Towards A Typology Of Mental Health Crisis Care Services For Children And Young People In England And Wales: A Cross-Sectional Survey And Analysis Of Implementation Practices, Clare Bennett, Claire Fraser, Ben Hannigan, Leanne Sawle, Jessy Williams, Aled Jones, Steven Pryjmachuk, Mair B. Elliott, Martin Elliott, Nicola Bennett, Euan Hails, Iain Mcmillan, Rachael Vaughan Dec 2025

Towards A Typology Of Mental Health Crisis Care Services For Children And Young People In England And Wales: A Cross-Sectional Survey And Analysis Of Implementation Practices, Clare Bennett, Claire Fraser, Ben Hannigan, Leanne Sawle, Jessy Williams, Aled Jones, Steven Pryjmachuk, Mair B. Elliott, Martin Elliott, Nicola Bennett, Euan Hails, Iain Mcmillan, Rachael Vaughan

School of Nursing and Midwifery

Background: The mental health and wellbeing of children and young people is a global concern. Alongside approaches emphasising mental health promotion in schools, communities and in the home, many countries are also investing in crisis services. These aim to meet the needs of young people experiencing acute psychosocial distress. A recent synthesis of the international evidence found a paucity of research in this area. This study sought to address this gap while simultaneously situating the findings within the international context and drawing out implications for policymakers and practitioners. Methods: A cross-sectional study aiming to describe and map approaches to the …

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Executive Function Among Older Adults With Bipolar Disorder: A Gage-Bd Analysis, Federica Klaus, Martha Sajatovic, Peijun Chen, Nicole Fiorelli, Ashley N. Sutherland Dec 2025

Executive Function Among Older Adults With Bipolar Disorder: A Gage-Bd Analysis, Federica Klaus, Martha Sajatovic, Peijun Chen, Nicole Fiorelli, Ashley N. Sutherland

Faculty Scholarship

Objectives Executive function deficits in bipolar disorder (BD) are major contributors to disability in older age BD (OABD). We investigated the difference between OABD and age-equated healthy comparators (HC); and, in the OABD group, the associations of executive function with age, symptom severity, global cognition, and daily functioning. Design Cross-sectional analysis of executive function in OABD versus HC. Setting Analysis of large archival dataset harmonized from 12 international OABD studies. Participants Older adults (≥50 years) with OABD ( n = 614) and HC ( n = 192). Measurements Executive function was assessed via Trail Making Test B (TMT-B) completion time; …

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Southern Adventist University Commencement Winter 2025, Southern Adventist University Dec 2025

Southern Adventist University Commencement Winter 2025, Southern Adventist University

Commencement Programs

Program for Southern Adventist University Winter 2025 graduation. The commencement service took place on December 18, 2025 at 7 pm in Iles Physical Education Center.

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