Digital Commons Network^™

Ai Performance In Emergency Medicine Fellowship Examination: Comparative Analysis Of Chatgpt-4o, Gemini 2.0, Claude 3.5, And Deepseek R1 Models, İshak Şan, Medi̇ne Akkan Öz, Mehmet Yortanli, Murat Genç, Bensu Bulut, Ayşenur Gür, Rami̇z Yazici, Hüseyi̇n Mutlu, Mustafa Önder Gönen

Turkish Journal of Medical Sciences

Background/aim: This study evaluated the accuracy rates and response consistency of four different large language models (ChatGPT- 4o, Gemini 2.0, Claude 3.5, and DeepSeek R1) in answering questions from the Emergency Medicine Fellowship Examination (YDUS), which was administered for the first time in Türkiye.

Materials and methods: In this observational study, 60 multiple-choice questions from the Emergency Medicine YDUS administered on 15 December 2024, were classified as knowledge-based (n = 26), visual content (n = 2), and case-based (n = 32). Each question was presented three times to the four large language models. The models’ accuracy rates were evaluated according …

The Importance Of Galectin-3 In The Diagnosis Of Childhood Acute Appendicitis ​, Onur Yalçin, Aybegüm Kalyoncu Ayçenk, Ali̇ Aygün, Ahmet Burak Günpinar, Mehmet Seyfetti̇n Saribaş, Volkan Altinok, Tevfi̇k Noyan

Turkish Journal of Medical Sciences

Background/aim: Acute appendicitis (AA) is a frequent indication for emergency surgery in children; accurate diagnosis is essential to prevent complications. We examined whether serum Galectin-3 is associated with pediatric AA and quantified its diagnostic performance relative to routine inflammatory markers.

Materials and methods: This prospective, single-center study was conducted in a tertiary emergency department between July 1, 2023, and January 31, 2024. Children younger than 18 years with pathologically confirmed AA were enrolled as cases; age-compatible healthy volunteers served as controls. Venous blood was obtained at presentation before any therapeutic intervention. Galectin-3 concentrations were quantified using a commercial enzyme-linked immunosorbent …

Letter To The Editor Regarding ‘‘Kara M, Alp G, Pekdiker M, Ketenci S, Porreca A Et Al. Evaluating Leflunomide Andmethotrexate Combination Vs. Monotherapy In Rheumatoid And Psoriatic Arthritis. Turkish Journal Of Medical Sciences: 2025; 55 (3): 632-643’’, Özge Tezen

Turkish Journal of Medical Sciences

No abstract provided.

Assessment Of Alterations In Regional Homogeneity And Amplitude Of Low-Frequency Fluctuations In Children With Dyslexia ​, Esra Demi̇rci̇, Şeri̇fe Gengeç Benli̇, Semra İçer, Zeynep Ak, Ebru Aker, Zehra Fi̇li̇z Karaman

Turkish Journal of Medical Sciences

Background/aim: Exploratory methods in neuroimaging are gaining increasing attention for revealing functional connectivity structures across the entire brain. This study aims to contribute to the understanding of the functional mechanisms underlying dyslexia, along with the effects of specialized education for dyslexia treatment, by utilizing measures such as regional homogeneity (ReHo), amplitude of low-frequency fluctuations (ALFF), and fractional ALFF (fALFF).

Materials and methods: Resting-state functional magnetic resonance imaging data were collected from three groups of Turkish-speaking children aged 7–12: diagnosed with dyslexia for the first time (Dys, n = 19), children with dyslexia who received specialized education (EDys, n = 20), …

Differential Patterns Of Gut And Oral Microbiomes In Hispanic Individuals With Cognitive Impairment, Yannick N. Wadop, Erin L. Vasquez, Julia J. Mathews, Jazmyn A. S. Muhammad, Rosa P. Mavarez, Claudia Satizabal, Mitzi M. Gonzales, Jeremy A. Tanner, Gladys E. Maestre, Bernard Fongang

School of Medicine Publications

Alterations in both oral and gut microbiomes have been associated with Alzheimer's disease and related dementia (ADRD). While extensive research has focused on the role of gut dysbiosis in ADRD, the contribution of the oral microbiome remains relatively understudied. This study aims to evaluate distinct patterns and potential synergistic effects of oral and gut microbiomes in a cohort of predominantly Hispanic individuals with cognitive impairment (CI) and without cognitive impairment (NC). We conducted 16S rRNA gene sequencing on stool and saliva samples from 32 participants (17 CI, 15 NC; 62.5% female, mean age = 70.4 ± 6.2 years) recruited in …

Insights From A Simple Mathematical Model Of Autism Spectrum Disorders, Charles F. Babbs

Weldon School of Biomedical Engineering Faculty Working Papers

This preliminary report explores insights about mechanisms of autism spectrum disorders (ASDs) gained from a mathematical model of interconnected clusters of excitatory neurons. This local, integrate-and-fire, spiking neural network is subjected to random noise from other populations of excitatory and inhibitory neurons outside the network. Its emergent behavior in response to different ratios of inhibitory to excitatory noise mimics several aspects of ASDs. The spiking neural network functions according to rules of classical neurophysiology, involving resting membrane potential, threshold potential, excitatory or inhibitory post-synaptic potentials, action potential, and refractory period. Key parameters include the incremental change in membrane potential, p …

Corrected Amicus Brief Filed By Amici Curiae Law Professors In 25-11612 & 25-11821, William Snape, Delicianna Winders, Patrick Parenteau, Christopher Courchesne, Hope Babcock, Holly Doremus, Paul Boudreaux, Oliver A. Houck, Zygmunt J.B. Plater, Michelle Benedict Nowlin, Daniel Rohlf

Amicus Briefs & Court Filings

STATEMENT OF THE ISSUES: Whether the district court's injunction requiring FDEP to cease Endangered Species Act-violating conduct, obtain an incidental take permit before it continues with the conduct, and implement reasonable protective measures violates principles of cooperative federalism, the Tenth Amendment, or the anti-commandeering doctrine.

Efficacy Of Autologous Platelet-Rich Fibrin (Prf) In Promoting Soft Tissue Healing And Bone Regeneration Following Extraction In The Anterior Maxilla: A Digital And Radiological Study, Anthony El Rai, Abdallah Menhall, Joseph Zaarour, Robin Jalkh, Joseph Bassil

International Arab Journal of Dentistry

Objectives: The main objective of this study was to evaluate the effectiveness of PRF in promoting soft tissue healing and bone regeneration after extraction in the anterior maxillary region. A secondary objective was to correlate soft tissue change with underlying bone structure variation. Finally, the study also aimed to compare soft and hard tissue alteration based on different types of extracted teeth.

Methods: The sample included five adult patients requiring the extraction of at least two symmetrical teeth in the anterior maxilla, totaling fourteen teeth. Participants underwent CBCT scans and digital impressions before extraction. Concerned teeth were then …

Comparative Evaluation Of Heat-Treated Retreatment Files On Canal Transportation And Dentin Thickness In Endodontically Treated Teeth: An In Vitro Cbct Study, Monisha Bhate, Pradeep Solete, Aparna Mohan

International Arab Journal of Dentistry

Introduction: Non-surgical retreatment is a conservative approach for managing recurrent endodontic infections requiring efficient removal of obturating material while preserving dentin. Retreatment file systems,through their design and function,plays a vital role in ensuring effective cleaning and minimal structural compromise.

Methods: Forty-five extracted mandibular molars were decoronated and obturated at a standardized root length of 16 mm in both mesial canals. Samples were divided into three groups (n=15): Group 1 – SoliteRS3, Group 2 – Dentsply Protaper Universal Retreatment Files and Group 3 – Neoendo Retreatment Files. Pre- and postoperative CBCT scans were used to assess remaining dentin thickness, …

Cytotoxicity And Osteogenic Potentials Of Mesenchymal Stem Cells Via A Novel Formulation Of Mineral Trioxide Aggregate: An In Vitro Study, Ahmed Elgendi, Ehab Hassanien, Mohamed Nagy, Iman Fathy, Ashraf Abu Seida, Elhassan Hassanein

International Arab Journal of Dentistry

Objectives: Root perforations can lead to periodontitis and alveolar bone loss. This study compared cytotoxicity and osteogenic potential of zirconia-containing mineral trioxide aggregate (MTA) Matreva (MAT group) to MTA Angelus (ANG group) as root perforation repair materials.

Methods: Bone marrow mesenchymal stem cells (BM-MSCs) were extracted from two albino rats and cultivated. The cytotoxicity of the studied materials was determined using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay at three time points: 3, 7, and 14 days. The evaluated materials were employed to guide the osteogenic differentiation of BM-MSCs into osteoblasts. The osteogenic impact was evaluated by assessing calcium …

Evaluation Of The Remineralizing Agents After Orthodontic Bracket Debonding: A Sem-Edx Investigation, Bassant Ashraf Badr, Medhat Elzainy, Noha Ibrahim, Hend El Messiry

International Arab Journal of Dentistry

Objectives: To compare the remineralizing efficacy of (Fluoride (Fl) Varnish, Nanohydroxyapatite (n-HAp) serum and NovaMin-containing toothpaste) on premolars subjected to orthodontic debonding and a pH-cycling model.

Methods: 60 human premolars were divided into six groups (n=10). Group IA, sound enamel, IB, orthodontically treated premolars, IC, orthodontically treated premolars subjected to demineralization cycles. Three experimental groups included orthodontically treated premolars subjected to demineralization cycles and treated with Fl varnish (IIA), n-HAp serum (IIB), and NovaMin toothpaste (IIC). Surface topography and mineral content were evaluated using SEM-EDX analysis, and data were statistically analyzed using ANOVA test and Tukey’s post-hoc test. …

Evaluation Of Anti-Bacterial Efficacy Of Ginger, Resin Gum, And Nigella Sativa Irrigants Against Enterococcus Faecalis: An In Vitro Study, Iman El Ghazzawy, Leen Imad Hasbini, Reem Chamseddine, Wael Betbout, Roula Abiad

International Arab Journal of Dentistry

Objectives: To evaluate the antibacterial efficacy of Ginger, Resin Gum, and Nigella Sativa, against Enterococcus Faecalis.

Methods: Thirty-eight extracted single-rooted premolars were inoculated with E.faecalis, except the negative control, and incubated for 4 weeks. After instrumentation samples were divided into 4 groups (n=7) according to final irrigation: NaOCl+EDTA (Group A), Nigella sativa (B), Resin Gum (C), Ginger (D), plus 2 control groups (n=5): Saline (E), and Saline without bacterial inoculation (F). Cultures were collected at baseline and after irrigation.

Results: One-way ANOVA showed that in groups A-D a statistically significant reduction of bacterial load was observed at …

Allergy In Dentistry: Mechanisms Of Development And Effective Treatment Methods, Maria Zofia Lisiecka

International Arab Journal of Dentistry

Objectives: This study is conducted to analyse the mechanisms of allergic reaction development in dentistry and the effectiveness of their treatment methods.

Methods: During it, a review of current scientific sources on allergology, immunology, dentistry, pharmacology, and materials science is conducted, mechanisms for the development of allergies of various types are established, the effectiveness of treatment methods is evaluated, and clinical recommendations for allergy therapy in dentistry are formed.

Results: The results show that the development of allergic reactions occurs by two mechanisms. Immediate-type immunoglobulin E-mediated (IgE-mediated) responses are triggered by the release of histamine, serotonin, and …

Impact On Oral Health Of The Post-Covid-19 Infections: A Systematic Review, Aouatif Aouidate, Hanane Ouddoud, Loubna Bahije

International Arab Journal of Dentistry

Introduction: The COVID-19 pandemic has been associated with a diverse range of oral health implications, including mucosal lesions, periodontitis, and disruptions of the oral microbiota. Since airborne particles primarily transmit COVID-19, understanding its potential impact on oral health is crucial for dental care and infection control.

Objectives: This systematic review aimed to evaluate the effects of post-COVID-19 infections on oral health, highlighting clinical manifestations, periodontal disease associations, and microbiota disturbances.

Methods: Electronic literature searches were conducted between January 2020 and July 2024 by one author across several databases, including PubMed/MEDLINE, Scopus, Cochrane Library, EMBASE, ScienceDirect, Google Scholar, …

Molecular Determinants Of Neoadjuvant Chemotherapy Resistance In Breast Cancer: An Analysis Of Gene Expression And Tumor Microenvironment, Hedda Michelle Guevara-Nieto, Carlos A. Orozco-Castaño, Rafael Parra-Medina, Jenny Nathaly Poveda-Garavito, Jone Garai, Jovanny Zabaleta, Liliana López-Kleine, Alba Lucia Combita

School of Graduate Studies Faculty Publications

Neoadjuvant chemotherapy (NAC) is a critical component of breast cancer treatment, but the molecular mechanisms underlying resistance remain poorly understood. This study aimed to identify transcriptomic changes associated with NAC resistance across four breast cancer subtypes: Luminal A, Luminal B/HER2-positive, Luminal B/HER2-negative, and Triple-Negative Breast Cancer (TNBC). RNA-seq analysis was performed on paired pre- and post-NAC breast cancer samples from 32 nonresponders. Differentially expressed genes (DEGs) were identified, and functional enrichment analyses were conducted. Protein-protein interaction (PPI) networks were constructed to identify hub genes. Tumor microenvironment (TME) infiltration was estimated using deconvolution algorithms. The results revealed distinct gene expression profiles …

The Clingen Severe Combined Immunodeficiency Disease Variant Curation Expert Panel: Specifications For Classification Of Variants In Ada, Dclre1c, Il2rg, Il7r, Jak3, Rag1, And Rag2, Vanessa C Jacovas, Michelle Zelnick, Shannon Mcnulty, Justyne E Ross, Namrata Khurana, Xueyang Pan, Alejandro Nieto, Shiloh Martin, Benjamin Mclean, Marwa A Elnagheeb, Morton J Cowan, Jennifer M Puck, Mike S Hershfield, James Verbsky, Jolan Walter, Eric J Allenspach, Alice Y Chan, Nicolai S C Van Oers, Rajarshi Ghosh, Megan Piazza, Bo Yuan, Luigi D Notarangelo, Britt A Johnson, Ivan K Chinn, Severe Combined Immunodeficiency Variant Curation Expert Panel

Faculty, Staff and Students Publications

Purpose: This collaborative study, led by the Clinical Genome Resource Severe Combined Immunodeficiency Disease Variant Curation Expert Panel (ClinGen SCID-VCEP), implemented and adapted the American College of Medical Genetics and Genomics/Association for Molecular Pathology (ACMG/AMP) guidelines for interpreting germline variants in genes with established relationships to SCID. The effort focused on the 7 most common SCID-related genes identified by SCID newborn screening in North America: ADA, DCLRE1C, IL2RG, IL7R, JAK3, RAG1, and RAG2.

Methods: The SCID-VCEP conducted a rigorous review of variants that involved database analyses, literature review, and expert feedback to derive gene-specific modifications to the ACMG/AMP guidelines. These …

Baseline Neurofilament Light Chain And Brain-Derived Neurotrophic Factor Levels Predict Development Of Aggressive Multiple Sclerosis, Ruzi̇ye Erol Yildiz, Ece Akbayir, Tuğçe Kizilay, Ayça Si̇may Ersöz, Duygu Özkan Yaşargün, Devran Süer, Vuslat Yilmaz, Erdem Tüzün, Recai̇ Türkoğlu

Turkish Journal of Medical Sciences

Background/aim: Patients with multiple sclerosis (MS) may present with a rapidly disabling clinical course in the first few years of disease. It is imperative to find biomarkers to predict patients with aggressive MS (AMS) and have an opportunity to prevent disability accumulation through appropriate treatment strategies. Our aim was to explore the prognostic value of neurofilament light chain (NFL) and brain-derived neurotrophic factor (BDNF) levels in cerebrospinal fluid (CSF) obtained in the early stages of MS.

Materials and methods: Relapsing-remitting multiple sclerosis (RRMS) patients presenting with first-time attacks were screened, of which 26 fulfilled AMS criteria in the 3-year follow-up …

Hesperidin Efficacy Of Epidural Fibrosis In A Post Laminectomy Rat Model: An Experimental Study, Emrah Keski̇n, Mehmet Seli̇m Gel

Turkish Journal of Medical Sciences

Background/aim: Epidural fibrosis (EF) plays a significant role in the development of failed back surgery syndrome (FBSS). This study evaluates the antifibrotic effect of hesperidin, a citrus-derived bioflavonoid, within a rat laminectomy model.

Materials and methods: Thirty-two female Wistar albino rats were randomized into four groups (n = 8 each). Group 1 received laminectomy alone (control); Group 2 received a gelatin sponge; Groups 3 and 4 intraperitoneally received 50 mg/kg and 100 mg/kg of hesperidin, respectively, for 7 days post-laminectomy. After 6 weeks, epidural tissues were assessed histopathologically, and hydroxyproline levels were measured.

Results: Group 4 showed significantly lower EF …

Investigating Patient Non-Attendance To Healthcare Appointments In Türkiye: Data From A State Hospital And An Oral And Dental Health Center, Eyüp Sari, Ali̇ Ni̇yazi̇ Kurtcebe, Ci̇han Döğer, Recep Aydin

Turkish Journal of Medical Sciences

Background/aim: To determine the frequency and reasons for appointment nonattendance in a state hospital and a dental health center in a densely populated district of Türkiye, and to identify related factors to guide preventive measures.

Materials and methods: This retrospective cross-sectional study included patients who scheduled appointments at Ankara Etimesgut State Hospital and Etimesgut Oral and Dental Health Center through the Centralized Patient Appointment System (Merkezi Hekim Randevu Sistemi; MHRS) in February 2024. Nonattendees were contacted in March 2024 to determine reasons for nonattendance.

Results: A total of 30,552 appointments were analyzed (1978 dental, 28,574 hospital). The overall nonattendance rate …

Unveiling The Potential Of Marine Peptides In Leukemia: Mechanistic Insights And Future Horizon In Peptide Research, Salman Ahmed, Waqas Alam, Khalaf Alsharif, Michael Aschner, Esra Küpeli̇ Akkol, Mamdouh Allahyani, Hayaa Alhuthali, Luci̇ano Saso, Esra Gi̇zem Türkcanoğlu, Haroon Khan

Turkish Journal of Medical Sciences

Leukemia is a malignant disorder that affects the bone marrow and blood. It is frequently diagnosed in adults, with a higher incidence in males than females. Globally, it ranks as the 15th most widespread cancer and is the 11th leading cause of cancer-related fatalities. The intensity and severity of treatment have increased, leading to a rise in relapse rates, toxicity, and adverse health effects. Therefore, there is a critical need for new treatments. The antileukemic properties of natural compounds have been extensively studied. Aquatic organisms are a rich source of potential medicinal compounds. Anticancer peptides offer an ideal treatment approach …

Generative Modeling For Interpretable Anomaly Detection In Medical Imaging: Applications In Failure Detection And Data Curation, Mckell E Woodland, Mais Altaie, Caleb S O'Connor, Austin H Castelo, Olubunmi C Lebimoyo, Aashish C Gupta, Joshua P Yung, Paul E Kinahan, Clifton D Fuller, Eugene J Koay, Bruno C Odisio, Ankit B Patel, Kristy K Brock

Faculty, Staff and Students Publications

This work aims to leverage generative modeling-based anomaly detection to enhance interpretability in AI failure detection systems and to aid data curation for large repositories. For failure detection interpretability, this retrospective study utilized 3339 CT scans (525 patients), divided patient-wise into training, baseline test, and anomaly (having failure-causing attributes—e.g., needles, ascites) test datasets. For data curation, 112,120 ChestX-ray14 radiographs were used for training and 2036 radiographs from the Medical Imaging and Data Resource Center for testing, categorized as baseline or anomalous based on attribute alignment with ChestX-ray14. StyleGAN2 networks modeled the training distributions. Test images were reconstructed with backpropagation and …

Candida Auris Screening, Positivity Trends, And Patient Characteristics At The University Of Kentucky Between 2021 And 2024, Faith Fursman, Natalie Fitzsimmons, Da Nelle Overton, Court Desmond, Kimberly Blanton, Kevin W. Hatton, Rachel Howard, David Olafsson, Sean Mctigue, Nicholas Van Sickels, Derek Forster, Takaaki Kobayashi

Surgery Faculty Publications

We evaluated a targeted Candida auris screening program, which revealed a 0.96% positivity rate. The proportion of community-onset cases increased from 8% to 54% following implementation. No significant differences in demographic or clinical characteristics were observed between patients with colonization and those with infection.

Characterization And Prediction Of Prolonged Severe Neutropenia In Pediatric Patients Receiving Tisagenlecleucel., Swati Naik, Subodh Selukar, Aimee C. Talleur, Samira Deshpande, Gabriela Llaurador Caraballo, Vanessa A. Fabrizio, Rayne H. Rouce, Xiaopei L. Zeng, Anant Vatsayan, Jenna Rossoff, Holly L. Pacenta, Samuel John, Christine L. Phillips, Julie-An Talano, Amy Moskop, Michael R. Verneris, G Doug Myers, Erin Hall, Nicole Karras, Challice L. Bonifant, Muna Qayed, Emily Bakinowski, Amy K. Keating, Susanne H C Baumeister, Emily Tomilson, Michelle L. Hermiston, Prakash Satwani, Christa Krupski, Vasant Chinnabhandar, Heather E. Stefanski, Emily Egeler, Kevin J. Curran, Theodore W. Laetsch, Crystal L. Mackall, Snehit Prabhu, Khanh P. Nguyen, Christina Baggott, Liora Michal Schultz, Kevin O. Mcnerney

Manuscripts, Articles, Book Chapters and Other Papers

Hematotoxicity is the most frequent severe toxicity after chimeric antigen receptor T-cell (CAR-T) therapy. However, limited data exist on risk factors and outcomes for hematotoxicity for children and young adults (CAYAs) with B-acute lymphoblastic leukemia treated with tisagenlecleucel. We conducted a multi-institutional study involving 326 CAYAs, with 144 evaluable in an initial training cohort and 141 evaluable in a validation cohort, through the Pediatric Real-World CAR Consortium to characterize the incidence and outcomes of prolonged severe neutropenia (PSN) and to develop a predictive risk score for PSN, tailored for use in this population. The incidence of PSN, defined as an …

Optimal Control In Combination Therapy For Heterogeneous Cell Populations With Drug Synergies., Simon F. Martina-Perez, Samuel W S Johnson, Rebecca M. Crossley, Jennifer C. Kasemeier, Paul M. Kulesa, Ruth E. Baker

Manuscripts, Articles, Book Chapters and Other Papers

Cell heterogeneity plays an important role in patient responses to drug treatments. In many cancers, it is associated with poor treatment outcomes. Many modern drug combination therapies aim to exploit cell heterogeneity, but determining how to optimise responses from heterogeneous cell populations while accounting for multi-drug synergies remains a challenge. In this work, we introduce and analyse a general optimal control framework that can be used to model the treatment response of multiple cell populations that are treated with multiple drugs that mutually interact. In this framework, we model the effect of multiple drugs on the cell populations using a …

Probabilistic Data Linkage To Study The Epidemiology Of Unintentional Fatal Drowning In A Large Metropolitan Region, Rohit P Shenoi, Ned Levine, Elizabeth A Camp, Linh Nguyen, Sandra Mckay, Shaila Zaman

Faculty, Staff and Students Publications

Background: It is difficult to study the epidemiology of drowning at the regional level because of multiple data sources, many of which have a high degree of unstandardized and missing data. We aimed to link multiple datasets to identify demographics and geographic locations of unintentional fatal drowning in a metropolitan region and compare linked data with vital statistic data.

Methods: This cross-sectional study included unintentional drowning fatalities among persons of all ages in metropolitan Houston between 2016 and 2022. Probabilistic linking was used to link multiple datasets and geographical mapping to identify drowning locations. The effectiveness of data linkage was …

Cloud Seeding: Enhancing Winter Snowpack To Bolster Utah's Water Supply, Lily Lambert, Kendall Becker, Binod Pokharel, Scott Hotaling

All Current Publications

As Utah’s climate warms, the state is working to combat the decline in winter snowpack caused by rising temperatures. Cloud seeding is a safe technology that, under the right conditions, can boost snowfall. In this fact sheet, we describe what cloud seeding is, where it is currently used in Utah, and the safety measures and management practices that ensure its responsible use.

Eutrophication, Hope Northagen, Sarah Erwin, Ethan Gilliam

All Current Publications

Eutrophication refers to the ecological state of a water body after excessive nutrient pollution. The external introduction of nutrients (primarily nitrogen and phosphorus) accelerates the growth and reproduction of plants, algae, and microbes. This fact sheet explains where eutrophication comes from, its impacts, how it is treated, and what you can do to help restore and protect our lakes, rivers, and oceans.

Optimizing Genetic Ancestry Adjustment In Dna Methylation Studies: A Comparative Analysis Of Approaches, Kira D Höffler, Seyma Katrinli, Matthew W Halvorsen, Anne-Kristin Stavrum, Kevin S O'Connell, Alexey Shadrin, Srdjan Djurovic, Ole A Andreassen, James J Crowley, Jan Haavik, Kristen Hagen, Gerd Kvale, Kerry Ressler, Bjarne Hansen, Jair C Soares, Gabriel R Fries, Alicia K Smith, Stéphanie Le Hellard

Faculty, Staff and Student Publications

Background: Genetic ancestry is an important factor to account for in DNA methylation studies because genetic variation influences DNA methylation patterns. One approach uses principal components (PCs) calculated from CpG sites that overlap with common SNPs to adjust for ancestry when genotyping data is not available. However, this method does not remove technical and biological variations, such as sex and age, prior to calculating the PCs. The first PC is therefore often associated with factors other than ancestry.

Methods: We developed and adapted the adapted EpiAnceR+ approach, which includes (1) residualizing the CpG data overlapping with common SNPs for control …

Impact Of Systemic Statins On Periodontal Health: A Retrospective Study In A Lebanese Population, Elsa Boustany, Georgio Saad, Wassim Al Manhal

International Arab Journal of Dentistry

Introduction: Statins, primarily used for cholesterol management, have shown potential in improving periodontal health due to their anti-inflammatory and bone-regenerative properties.

Methods: A retrospective study was conducted on 30 patients under statin medication. A control group of 30 non-statin users was selected using propensity score matching (PSM) to minimize bias. Data on pocket depth, attachment loss, and radiographic bone loss were collected at two time points: T0 and T1. Statistical analysis was performed using RStudio, with a significance threshold set at p < 0.05.

Results: The study revealed significant decrease in pocket depth (p = 0.0027), attachment loss (p …

Assessment Of External Root Resorption During The First Stage Of The Orthodontic Treatment: A Prospective Cone-Beam Tomography Study, Eliana Pineda Vélez

International Arab Journal of Dentistry

Introduction: predisposition to root resorption as a result of a dental movement may be a consequence of clinical, biological, and biomechanical factors that should lead the clinician to objectively assess each patient to reduce associated risk factors.

Objectives: to establish an association between clinical and tomographic findings related to external root resorption (ERR) using cone beam tomography (CBCT) on maxillary incisors during the first stage of the orthodontic treatment. Methods: an observational, follow-up, cohort study that analyzed the association between clinical and radiographic variables on maxillary incisors using CBCT before placing fixed orthodontic appliances and finishing the first …