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November 6, 2025, James Madison University

The Breeze, 2020-

The Breeze is the student newspaper of James Madison University in Harrisonburg, Virginia.

Investigating Whether Giving Or Receiving Support Impacts Caregivers Who Were Maltreated Or Not Maltreated Differently, Tara D. Matta-Singh

USF Tampa Graduate Theses and Dissertations

Caregivers can experience higher levels of stress, anxiety and depression compared to non-caregivers. However, a growing body of literature is beginning to show that while caregiving may be stressful, there may also be benefits to the caregiver, such as feeling closer to the care recipient, a sense of purpose or personal growth. Further, research now demonstrates that giving support to others can be more beneficial than receiving support from others in terms of mental health and even mortality. While these are important advances in the literature, understanding the impacts of giving and receiving support on individuals who were maltreated by …

Aberrant Expression Of A Disintegrin And Metalloproteinase With Thrombospondin Motifs 13 (Adamts13) In Pancreatic Cancer Leads To Dichotomic Functions, Stephanie Allmang, Hagen R. Witzel, Anne Hausen, Simone Marquard, Christoph Eckert, Nicole Marnet, Nina Hörner, Philipp Mayer, Stefan Heinrich, Hien Dang, Wilfried Roth, Matthias M. Gaida

Department of Surgery Faculty Papers

Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive cancers characterized by highly invasive growth into the surrounding peripancreatic fat tissue, where tumor cells can directly interact with adipocytes. Due to poor response to the currently available (radio)chemotherapies, there is an urgent need for advanced therapy concepts. The present study shows that ADAMTS13 (a disintegrin and metalloproteinase with thrombospondin motifs 13), a key factor in blood coagulation, is significantly overexpressed in human PDAC. Immunohistochemical analysis revealed that ADAMTS13 expression is associated with prolonged survival and negatively correlated with vascular density. In vitro and in vivo experiments demonstrate its partial …

Emotional Hypervigilance: Development Of A New Questionnaire And Examining The Importance To Posttraumatic Quality Of Life., Alison Bacon, Alyson Norman

School of Psychology

Objective: Hypervigilance is a symptom of posttraumatic stress disorder usually defined in terms of behaviours such as environment scanning and planning escape routes. The objective of Study 1 was to develop a new measure to assess the extent to which individuals employ a specifically emotional form of hypervigilance. The aim of Study 2 was to investigate whether emotional hypervigilance is associated with posttraumatic quality of life in addition to the known effects of symptoms and experiential avoidance. Method: Study 1 presents the development and initial testing (N = 275) of the Emotional Vigilance and Awareness Questionnaire (EVAQ). In Study 2, …

Mechanisms Of Antibody-Mediated Protection In Severe Acute Respiratory Syndrome Coronavirus 2 Infection, Samantha Mackin

Arts & Sciences Graduate Student Theses and Dissertations

ABSTRACT OF THE DISSERTATION Mechanisms of Antibody-Mediated Protection in Severe Acute Respiratory Syndrome Coronavirus 2 Infection by Samantha Rae Mackin Doctor of Philosophy in Biology and Biomedical Sciences Immunology Washington University in St. Louis, 2025 Professor Michael S. Diamond, Chair Coronaviruses (CoVs) are enveloped, non-segmented, positive-sense RNA viruses belonging to the Coronaviridae family. The subfamily Coronavirinae includes four genera: alpha-, beta-, gamma-, and deltacoronaviruses. While gamma- and deltacoronaviruses primarily circulate in wild or domestic birds and have shown the potential for cross-species transmission, alpha- and betacoronaviruses mainly infect mammals, resulting in respiratory illnesses that can be mild or severe. Over …

2025 November 6 - From My Notepads Newsletter, Office Of The President, East Tennessee State University, Brian Noland

From My Notepads: A Newsletter from President Brian Noland

No abstract provided.

Lipedema And Adipose Tissue: Current Understanding, Controversies, And Future Directions, Atefeh Rabiee

Pacific Faculty Work

Lipedema is a chronic disorder characterized by the symmetrical accumulation of subcutaneous adipose tissue, predominantly affecting women. Despite increasing recognition, the pathophysiological mechanisms underlying adipose tissue dysfunction in lipedema remain incompletely understood. This mini review combines current knowledge about adipose tissue biology in lipedema, highlighting recent discoveries, ongoing controversies, and future research directions. A comprehensive literature review was conducted focusing on adipose tissue-related research in lipedema with emphasis on pathophysiological mechanisms, cellular composition, and therapeutic implications. Recent studies reveal that lipedema adipose tissue exhibits distinct characteristics, including M2 macrophage predominance, stage-dependent adipocyte hypertrophy, progressive fibrosis, and altered lymphatic/vascular function. The …

The Colby Echo (2025-11-06), Colby College

The Colby Echo

Published by the students of Colby College since 1877, The Colby Echo is the weekly, editorially independent student-run newspaper of Colby College in Waterville, Maine. Published monthly, 1877-1886; semi-monthly, 1886-1897; and weekly during the academic year, 1898-present.

Her3 Promotes Triple-Negative Breast Cancer Progression By Upregulating Phf8 Via Mir-34b-5p-Dependent Mechanism, Hui Lyu, Cong Cong Tan, Yakun Wu, Margaret E. Larsen, Qingzhao Yu, Guobin Kang, Charles Wood, Shou Ching Tang, Bolin Liu

School of Graduate Studies Faculty Publications

Triple-negative breast cancer (TNBC) is one of the most aggressive subtypes of breast cancer, with limited targeted treatment options and poor clinical outcomes. HER3 has recently emerged as a promising therapeutic target, with HER3-directed antibody–drug conjugates advancing to Phase III clinical trials for non-small cell lung cancer. However, the downstream molecular mechanisms by which HER3 promotes TNBC progression remain poorly defined. In this study, we uncovered a previously unrecognized HER3/miR-34b-5p/PHF8 signaling axis that drives TNBC cell proliferation and tumor growth. Mechanistically, HER3 activation suppresses the tumor-suppressive microRNA miR-34b-5p, resulting in the upregulation of the histone demethylase PHF8 (KDM7B), which in …

The Utility Of Ultra-Deep Rna Sequencing In Mendelian Disorder Diagnostics, Sen Zhao, Jefferson C Sinson, Shenglan Li, Jill A Rosenfeld, Gladys Zapata, Kristina Macakova, Mezthly Pena, Becky Maywald, Kim C Worley, Lindsay C Burrage, Monika Weisz-Hubshman, Shamika Ketkar, William Craigen, Lisa Emrick, Undiagnosed Diseases Network, Tyson Clark, Gila Yanai Lithwick, Zohar Shipony, Christine Eng, Brendan Lee, Pengfei Liu

Faculty, Staff and Students Publications

RNA sequencing (RNA-seq) has emerged as a powerful tool for resolving variants of uncertain significance (VUSs), particularly those affecting gene expression and splicing. However, most reference datasets and diagnostic protocols employ relatively modest sequencing depths (∼50-150 million reads), which may fail to detect low-abundance transcripts and rare splicing events critical for accurate diagnosis. We evaluated the diagnostic and translational utility of ultra-high-depth (up to ∼1 billion unique reads) RNA-seq in four clinically accessible tissues using the Ultima sequencing platform. After validating the performance of Ultima RNA-seq, we investigated how increasing sequencing depth affects gene and isoform detection, splicing variant discovery, …

Quality Assurance Report For Year 2024 Estuarine Water Quality Datasonde Monitoring, Lara M. Martin

PREP Reports & Publications

No abstract provided.

Perpetration-Induced Traumatic Stress And Moral Injury In Adult Male Incarcerated Individuals, Cyrelah Jeanee Raynor

Walden Dissertations and Doctoral Studies

Underutilizing trauma-informed approaches in correctional rehabilitation has had detrimental consequences, particularly for gang-involved populations. Theories of personality, responsivity, and stress suggest that gang-affiliated individuals, shaped by coercive environments, may develop psychological reactions such as fear, guilt, and moral shame that contribute to posttraumatic stress disorder (PTSD) and moral injury (MI). This study examined whether gang role, psychopathy, and perpetration predicted PTSD and MI among 70 incarcerated adult males. Participants completed the Moral Injury Outcome Scale (MIOS), the PTSD Checklist for DSM-5 (PCL-5), and the Levenson Self-Report Psychopathy Scale (LSRP). Two hierarchical regressions were conducted. In the PTSD model, only education …

Supreme Court Ruling Lets Trump Misgender Trans People On Passports While Challenge Is Pending, Arthur S. Leonard

Other Publications

No abstract provided.

Communicating The Truth-Telling And Space-Making Of Black Women In Higher Education: A Trap Feminist Study, Chazman Deira Mckoy

USF Tampa Graduate Theses and Dissertations

This dissertation adopts a “for Black women, by Black women” approach to examine how Black women’s lived experiences and performances of racialized gender become communicative acts of agency as they navigate the intersecting challenges of race and gender within pedagogical contexts.

Grounded in Black Feminist Pedagogy and expanded through Trap Feminism, this study celebrates the complexity of racialized gender performances and theorizes them as intentional communicative acts of resistance. These acts not only confront dominant ideologies but also create ongoing spaces for truth-telling, spaces where Black women can reframe how their stories, labor, and brilliance are recognized in academic contexts …

Can Dietary Supplements Support Muscle Function And Physical Activity? A Narrative Review, Louise Brough, Gail Rees, Lylah Drummond-Clarke, Jennifer E. Mccallum, Elisabeth Taylor, Oleksii Kozhevnikov, Steven Walker

School of Biomedical Sciences

Dietary supplementation is commonly used by athletes to gain muscle mass, enhance performance, and improve recovery. Most adults engage in insufficient physical activity. Yet healthy muscles are also critical for activities of daily living (ADLs), maintaining a good quality of life and positive ageing. There is growing interest in whether dietary supplementation is of value, particularly among subgroups such as the occasionally active, the ill and elderly, and peri- and menopausal women. By focusing on function, performance, mass and strength, ADLs, exercise-induced muscle damage and delayed onset muscle soreness, this review sought to examine muscle health through a nutritional lens. …

Mutational Landscape And Clinical Impact Of Spen Mutations In Patients With Chronic Lymphocytic Leukemia, Priyatharsini Nirmalanantham, Andrés E Quesada, Anindita Ghosh, Pei Lin, Chi Y Ok, Richard K Yang, Hong Fang, Sofia Garces, Rashmi Kanagal-Shamanna, Sanam Loghavi, Mark J Routbort, Cameron Cheng Yin, Wang Wei, Sarah Pasyar, Roland Bassett, Siba El Hussein, Nitin Jain, Jan Burger, William G Wierda, Sa Wang, Carlos Bueso-Ramos, Keyur P Patel, Leonard Jeffrey Medeiros, Fatima Zahra Jelloul

Faculty, Staff and Student Publications

Background/objectives: NOTCH1 is frequently mutated in chronic lymphocytic leukemia (CLL) and is a marker of poor prognosis. In addition to NOTCH1, mutations in the NOTCH1 regulatory pathway including SPEN have been described in a limited number of CLL cases and others have suggested that these mutations are also associated with adverse patient outcomes Methods: In this study, 1617 CLL cases were assessed using targeted sequencing and a 29-gene panel and the results were correlated with prognosis.

Results: SPEN mutations were detected in 48 (2.9%) CLL patients: 92.4% were deleterious (frameshift or truncating nonsense mutations) and the remaining (7.6%) were …

Treatment Planning For Patients With Acoustic Neuroma., Andrew J. Fishman, Oskar Rosiak, Arnaldo Rivera, Michael D. Puricelli, Nenad Zivkovic, Jozef Mierzwinski, Bojan Markovic, Natalija Milisavlevic, Radosław Rola, Marcin Szymanski

Manuscripts, Articles, Book Chapters and Other Papers

INTRODUCTION: Acoustic neuroma (AN) is a benign tumor of the vestibulocochlear nerve, with increasing detection due to improved imaging. Treatment decisions are complex, requiring an individualized approach based on tumor size, location, growth rate, and patient-specific factors such as hearing and vestibular function.

RESULTS: Treatment options include observation, microsurgery, and stereotactic radiosurgery. Hearing preservation is prioritized in select cases using middle cranial fossa or retrosigmoid approaches, while translabyrinthine surgery is preferred for larger tumors or disabling dizziness. Stereotactic radiosurgery offers a non-invasive alternative but has variable long-term hearing outcomes and potential tumor regrowth. Vestibular rehabilitation is essential post-treatment, particularly after …

A Collaborative Approach To Marine Species Tracking: Insights From The Fish Intel Acoustic Telemetry Network, Alice E. Hall, Tom Stamp, Peter Davies, Mathieu Woillez, Martial Laurans, Marine Gonse, Lydie I.E. Couturier, Olivier Blanpain, Katia Frangoudes, Emmanuelle Quillérou, Eider Graner, Jan Reubens, Carlotta Muñiz, Lucy A. Hawkes, Matthew J. Witt, Thomas W. Horton, Tom Hooper, Ricky Pender, Erwin Quemeneur, Mewen Abjean, Xavier Tetard, Pascal Provost, Silvana Birchenough, Jean Luc Solandt, Colin Trundle, Amy Y. Cartwright, Sian Rees, Ronan Conlon, Shion E.A. Reynell, Ben Ciotti

School of Biological and Marine Sciences

Acoustic telemetry offers valuable insights into species' spatial and temporal movement patterns, helping to understand habitat use, behaviour and migration timings. The Fish Intel Network established a collaborative cross-English Channel acoustic telemetry network to track multiple species over small and large spatial scales. This network was designed in close alliance with local fishers to incorporate essential local ecological knowledge of target species and habitats, gathered through interviews and workshops. To date, 254 acoustic receivers have been deployed, and 874 animals have been tagged across the Channel. Six species were tracked for this study: European bass (Dicentrarchus labrax), pollack (Pollachius pollachius), …

Advancing Delirium Detection Through The Open Health Natural Language Processing Consortium And The Evolve To Next-Gen Accrual To Clinical Trials Network, Sunyang Fu, Min Ji Kwak, Jaerong Ahn, Zhiyi Yue, Shreyas Ranganath, Joseph R Applegate, Andrew Wen, Liwei Wang, Chenyu Li, Michele Morris, Kelly M Toth, Timothy D Girard, John D Osborne, Richard E Kennedy, Nelly-Estefanie Garduno-Rapp, Phillip Reeder, Justin F Rousseau, Chao Yan, You Chen, Mayur B Patel, Tyler J Murphy, Bradley A Malin, Chan Mi Park, Heling Jia, Sandeep Pagali, Allyson K Palmer, Jennifer St Sauver, Sunghwan Sohn, Elmer V Bernstam, Shyam Visweswaran, Yanshan Wang, Hongfang Liu

Faculty, Staff and Student Publications

Background: Delirium is often underdiagnosed in clinical practice and is not routinely coded for billing. While manual chart review can identify delirium, it is labor-intensive and impractical for large-scale studies. Natural language processing (NLP) can analyze unstructured text in electronic health records (EHRs) to extract meaningful clinical information.

Methods: To support national integration of NLP for EHR-based delirium identification across different institutions, we launched the Delirium Interest Group within the national Evolve to Next-Gen Accrual to Clinical Trials (ENACT) NLP Working Group. This paper outlines our initial efforts to standardize, evaluate, and translate an NLP-based delirium detection model into the …

Distinct Tumor-Associated Macrophage Signatures Shape The Immune Microenvironment And Patient Prognosis In Renal Cell Carcinoma, Youngsoo Han, Aidan Shen, Cheng-Chi Chao, Lucas Yeung, Aliesha Garrett, Jianming Zeng, Satoru Kawakita, Jesse Wang, Zhaohui Wang, Alireza Hassani, Xiling Shen, Chongming Jiang

Faculty, Staff and Student Publications

Renal cell carcinoma (RCC) accounts for 90% of adult renal cancer cases and is characterized by significant heterogeneity within its tumor microenvironment. This study tests the hypothesis that tumor-associated macrophages (TAMs) influence RCC progression and patient response to treatment by investigating the prognostic implications of TAM signatures. Utilizing independent single-cell RNA sequencing data from RCC patients, we developed eight distinct TAM signatures reflective of TAM presence. A LASSO Cox regression model was constructed to predict survival outcomes, evaluated using the TCGA dataset, and validated across independent RCC cohorts. Model performance was assessed through Kaplan-Meier survival plots, receiver operating characteristic (ROC) …

Menin Inhibitor Ds-1594b Drives Differentiation And Induces Synergistic Lethality In Combination With Venetoclax In Acute Myeloid Leukemia Cells With Rearranged Mixed-Lineage Leukemia And Mutated Nucleophosmin-1, Valerio Ciaurro, Vassilena Sharlandjieva, Anna Skwarska, Catherine Chahrour, Natalia Baran, Zhihong Zeng, Cassandra Ramage, Naval Daver, Bing Z Carter, Sovira Chaundhry, Palaniraja Thandapani, Maria Paola Martelli, Thomas A Milne, Marina Konopleva

Faculty, Staff and Student Publications

Mixed-lineage leukemia (MLL) rearrangements and Nucleophosmin-1 (NPM1) mutations are associated with acute leukemias whose pathogenesis is critically influenced by protein-protein interactions between menin and MLL. We hypothesized that targeting the menin-MLL interaction using DS-1594b and blocking the antiapoptotic BCL-2 protein using venetoclax may promote differentiation and enhance eradication of MLL-rearranged and NPM1-mutated leukemias models. We treated acute myeloid leukemia (AML) cell lines with MLL rearrangements, NPM1 mutations, other leukemias and primary samples from AML patients with venetoclax alone, DS- 1594b alone, and their combination. We measured proliferation, viability, apoptosis, and differentiation using a variety of cellular assays, Western blotting, and …

Fostering Entrepreneurial Thinking And Practice Through Teaching And Learning Integration, Mohammad G. Sabbir

Learning and Educational Center Virtual Teaching and Learning Conference

This session explores an innovative, evidence-based approach to integrating entrepreneurial thinking into undergraduate neuroscience education through hands-on gene editing experiences. Using the commercially available Bio-Rad CRISPR/Cas9-based “Out of the Blue” kit for bacterial LacZ gene editing, students are guided not only through the scientific principles underlying modern gene editing technologies but also through the entrepreneurial challenge of replicating and manufacturing the kit using existing lab resources. This model empowers students to extend their learning beyond the classroom by engaging in cost-effective, scalable biotechnology practices—particularly valuable for institutions with limited funding. Classroom-based research demonstrates increased student engagement, deeper conceptual understanding, and …

Why The Irish Don’T Eat Offal, Niall Toner

European Journal of Food Drink and Society

In the past fifty years or so, the diverse and colourful displays of animal offal and organ meats that used to be seen in butchers’ shop windows in Ireland, as well as in the UK and America, have all but disappeared. In Ireland, which has seen a gastronomic renaissance in more recent times, these traditional foodstuffs appear to have been slow to return to our plates. But have offal and organ meats a place in the future of the cuisine, and can the increased consumption of offal and organ meats, produced locally, contribute towards a more sustainable food production system, …

“Add What You Think Proper”: Exploring The Culinary Narrative Of Newbridge House Through The Cobbe Recipe Book (1806–1838) And Archive, Cathal Dowd Smith

European Journal of Food Drink and Society

Newbridge House, in north County Dublin, was built in 1747 by Archbishop of Dublin, Charles Cobbe to designs by prominent architect James Gibbs. Having arrived in Ireland in 1717, acquiring land and ecclesiastical promotion, Cobbe settled in north Dublin and built a house in the Palladian vision for his family. In 1755 his heir and sole surviving son Thomas married Lady Elizabeth ‘Betty’ Beresford, daughter of the 1st earl of Tyrone. Together Thomas and Lady Betty assembled an art collection at Newbridge, extending the house for that purpose. Included in that extension were more bedrooms, but, importantly here, increased servants’ …

“Owned And Controlled By Negroes”: Allensworth And The Study Of Subnational Space, Amy Hart

Communal Societies

No abstract provided.

Factors Affecting Public Knowledge About Ocd Mental Health Literacy, Lauren Angell, Aleena Babu, Jimmy Dumont, Lauren Masapollo, Kaitlyn Silva

The Graduate Review

This research project aimed to examine how varying portrayals of obsessive-compulsive disorder (OCD) influence public mental health literacy (MHL). Our research questions focused on the impact of multidimensional vs single portrayals of OCD on OCD MHL, as well as the influence of certain sociodemographic factors on OCD MHL. Additional exploratory questions were investigated and aimed to explain the relationship between OCD MHL and media, as well as OCD MHL and education levels. To investigate these questions, the study employed a combination of experimental and survey-based methods. By fostering greater awareness of misinformation about OCD, the study not only aimed to …

Religion's Role In Shaping Psychopathological Narratives, Andrea Gonzalez Mendoza

The Graduate Review

Understanding the interplay between religion and psychopathology is essential for clinicians navigating the complexities of mental health diagnosis and treatment. This paper explores the nuanced relationship between belief systems and diagnostic frameworks, shedding light on how religious beliefs influence the perception, assessment, and treatment of mental disorders. Drawing upon historical and current-day research, this paper examines how religious interpretations shape the presentation and understanding of psychopathological symptoms. In doing so, this paper argues that psychopathology cannot be understood without considering the influence of religion on its conceptualization. The latter is illustrated by looking at historical diagnostic patterns and how they …

Pearl Buck’S Humanitarian Vision In War And Peace, David M. Crowe

Presidential Fellows Articles and Research

"Eurasia, that vast continental region that encompasses Europe and Asia, was a tablet for many of Pearl S. Buck’s works and campaigns for human rights and international efforts to improve the human condition globally. Though she is principally known for her works on China, some scholars, while acknowledging that her novels were principally for an American female audience, gave little attention to her significant body of non-fictional works on a variety of subjects on America and East Asia. I made my first trip to China in the summer of 1985 via the Trans-Siberian Railroad and Mongolia to Beijing."

Sunburned Plankton: Ultraviolet Radiation Inhibition Of Phytoplankton Photosynthesis In The Community Earth System Model Version 2, Joshua Coupe, Nicole S. Lovenduski, Luise S. Gleason, Michael N. Levy, Kristen Krumhardt, Keith Lindsay, Charles Bardeen, Clay Tabor, Cheryl Harrison, Kenneth G. Macleod, Siddhartha Mitra, Julio Sepúlveda

Faculty Publications

Ultraviolet (UV) radiation can damage DNA and kill cells. We use laboratory and observational studies of the harmful effect of UV radiation on marine photosynthesizers to inform the implementation of a UV radiation damage function for phytoplankton photosynthesis in a modified version of the Community Earth System Model version 2 (CESM2-UVphyto). CESM2-UVphyto is capable of simulating UV inhibition of photosynthesis among modeled phytoplankton and ocean column penetration of UV-A, UV-B, and UV-C radiation. We conduct a series of simulations with CESM2-UVphyto using the Marine Biogeochemistry Library (MARBL) ecosystem model to understand the sensitivity of phytoplankton productivity to UV radiation. Results …

The Perceptions Of Foster Care Alumni Who Are Recipients Of Pandemic Aid, Ashley Robinson

Walden Dissertations and Doctoral Studies

The COVID-19 pandemic heightened challenges for young adults transitioning from foster care to independence. Research shows that foster care alumni faced barriers in education, employment, housing, and health due to limited support networks. Yet, little is known about how emergency policies, such as the Consolidated Appropriations Act (CAA) of 2021, affected them. The purpose of this qualitative study was to explore the perceptions and experiences of foster care alumni who received financial aid through the Act. The research question: What were the experiences and perceptions of foster care alumni (aged 18-26) who received funds via the CAA of 2021 during …