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Articles 21121 - 21150 of 818072
Full-Text Articles in Entire DC Network
When Cpu Is Worse Than A Stick In The Eye: Better Kpis For Strategic Journal Collection Management, Evan Rusch, Heidi J. Southworth, Nat Gustafson-Sundell
When Cpu Is Worse Than A Stick In The Eye: Better Kpis For Strategic Journal Collection Management, Evan Rusch, Heidi J. Southworth, Nat Gustafson-Sundell
Library Services Publications
A video of this presentation is available as an Additional File and also available at https://link.mnsu.edu/kpis-video.
Libraries frequently rely on variously calculated cost-per-usage (CPU) metrics, but there are other key performance indicators (KPIs) often more strategic for journal collection assessment. These other KPIs can also be more effective for communicating the value of journals. While CPU, in a variety of forms, will probably always be important for evidence-based decision-making, CPU can sometimes obfuscate the real value provided by journal packages and individual journals. We will discuss how CPU can lead to false impressions, especially at the package level. We’ll …
Interview With Orca Award Winner James Van Etten, Unl Plant Pathology; Discoverer Of Giant Viruses, Mark Griep, James Van Etten
Interview With Orca Award Winner James Van Etten, Unl Plant Pathology; Discoverer Of Giant Viruses, Mark Griep, James Van Etten
UNL ORCA Interview Series
Dr. James Van Etten was awarded the UNL Outstanding Research and Creative Activities Award in 1992. He was born in Virginia but grew up Peoria, Illinois. Something in his youth must have sparked an interest in science because he earned his bachelor’s degree in biology from Carleton College in 1960. Carleton is a well-regarded liberal arts institution in Northfield, Minn., about 400 miles from Peoria. Next, Jim earned a master’s and doctorate at the University of Illinois in Champaign-Urbana, both in plant pathology. For his postdoctoral work in 1965 and 1966, he did postdoctoral work in the Department of Genetics …
European Seabass (Dicentrarchus Labrax) Neurocranium, Gianna Dib, Logan A. Murphy, Esmeralda Orozco, David W. Kerstetter
European Seabass (Dicentrarchus Labrax) Neurocranium, Gianna Dib, Logan A. Murphy, Esmeralda Orozco, David W. Kerstetter
All Scans: Kerstetter Fisheries and Avian Ecology 3D Scan Series
No abstract provided.
Coryphaena Hippurus (Mahi-Mahi) Neurocranium, Victoria E. Acosta, Margaret L. Mantineo, Sienna Lazar, Loren Hart, David W. Kerstetter
Coryphaena Hippurus (Mahi-Mahi) Neurocranium, Victoria E. Acosta, Margaret L. Mantineo, Sienna Lazar, Loren Hart, David W. Kerstetter
All Scans: Kerstetter Fisheries and Avian Ecology 3D Scan Series
No abstract provided.
Citronellol Reduces Sepsis-Induced Renal Inflammation Via Ap-1/Nf-Κb/Tnf-Α Pathway, Huda Rashid Atiyah, Sarmed H. Kathem, Surya M. Nauli
Citronellol Reduces Sepsis-Induced Renal Inflammation Via Ap-1/Nf-Κb/Tnf-Α Pathway, Huda Rashid Atiyah, Sarmed H. Kathem, Surya M. Nauli
Pharmacy Faculty Articles and Research
Sepsis is characterized by the over-production of pro-inflammatory cytokines. Cecal ligation and puncture (CLP) is a well-accepted model for recreating sepsis-induced renal injury in mice. The current study investigates how citronellol, a naturally occurring substance with a variety of biological characteristics, can prevent acute kidney inflammation brought on by CLP. In the CLP mouse model, citronellol was administered orally at doses of 50 and 100 mg/kg. Serum levels of creatinine and urea were used as markers of renal function, and the Murine Sepsis Score (MSS) was used to assess the severity of sepsis. According to our findings, CLP caused a …
Development And Validation Of A Narrative-Based Personal Epistemology Scale: A Rasch-Guttman Scenario Approach, Luke Walden
Development And Validation Of A Narrative-Based Personal Epistemology Scale: A Rasch-Guttman Scenario Approach, Luke Walden
Electronic Theses and Dissertations Archive
Quantitative measurement of personal epistemology has faced persistent challenges, with previous instruments often demonstrating poor psychometric functioning and instability across studies. This study introduces and provides an argument for the validity of the Epistemic Reasoning Measure (ERM), a novel scenario-based instrument utilizing the Rasch Guttman Scenario (RGS) methodology to assess absolutism and multiplism across a well-structured (biology) and an ill-structured (history) domain. A pilot sample of 350 undergraduate students and a second wave of 357 undergraduate students completed the four variants of the ERM (absolutism and multiplism for both biology and history). The psychometric properties of the scales were evaluated …
Introducing Neuro Sscial Work: A Brief Reflection On Neuroscience And The Profession, Priscila Llamosa
Introducing Neuro Sscial Work: A Brief Reflection On Neuroscience And The Profession, Priscila Llamosa
Social Work Faculty Publications
This reflection introduces and contextualizes the term Neuro Social Work, which I coin to name a specialized practice area at the intersection of social work, neuroscience, and neurodiversity. Drawing on my experience as a social work educator and practitioner, I discuss social work’s uneasy relationship with neuroscience, marked both by the opportunity to deepen our understanding of trauma, development, and healing, and by the risks of using brain‑based evidence to individualize structural harms or justify surveillance of marginalized communities. I outline, in broad strokes, what distinguishes Neuro Social Work from general neuroscience‑informed practice. The note is intended as a concept …
The Daily Gamecock: November 2025, University Of South Carolina, Office Of Student Media
The Daily Gamecock: November 2025, University Of South Carolina, Office Of Student Media
2025
No abstract provided.
Policy Project: Creating An Animal Assisted Therapy Policy For A College Of Nursing, Brooke Peyton
Policy Project: Creating An Animal Assisted Therapy Policy For A College Of Nursing, Brooke Peyton
Doctor of Nursing Practice Projects
Nursing students experience high levels of academic stress, anxiety, and burnout, which can negatively impact learning, professional development, and overall health. Evidence indicates that Animal-Assisted Therapy (AAT) has the potential to impact stress levels, improve community connection, and enhance overall well-being among nursing students. Many academic institutions lack structured policies to guide AAT programs into educational settings. The purpose of this Doctor of Nursing Practice project was to develop a formal AAT policy for the College of Nursing with standardized procedures to implement an AAT program. Rogers’ Diffusion of Innovations theoretical framework was used to guide the development of the …
Quality Improvement Project Step Into Serenity: How Walking Can Ease Stress For Nursing Faculty, Stefanie Martinez
Quality Improvement Project Step Into Serenity: How Walking Can Ease Stress For Nursing Faculty, Stefanie Martinez
Doctor of Nursing Practice Projects
This quality improvement project explored whether incorporating scheduled walk breaks could help reduce perceived stress among accelerated Bachelor of Science in Nursing (ABSN) faculty. High levels of stress and burnout continue to affect nursing educators and contribute to faculty turnover and workforce shortages. The goal of this project was to promote physical activity as a simple and accessible approach to supporting well-being and fostering a healthier work environment. Grounded in George Engel’s Biopsychosocial Model of Health, this project introduced an educational session on faculty stress, burnout, and the benefits of walking. Participants completed the Perceived Stress Scale (PSS-10) before and …
Face Card Declined: The Deepfake Threat To Biometric Security In Financial Systems, Hazel Fernandez
Face Card Declined: The Deepfake Threat To Biometric Security In Financial Systems, Hazel Fernandez
Washington and Lee Law Review Online
Once limited to entertainment and disinformation, deepfakes are now extending into the financial sector, where voice and facial impersonations exploit biometric authentication systems to facilitate fraudulent transactions. This evolution exposes gaps in existing legal and regulatory frameworks, raising critical questions about consumer protection and institutional safeguards. This Note argues for a reconceptualization of deepfake harms as both a privacy and a financial security issue. It examines the illusion of consent generated by synthetic impersonation and insufficient statutory protections. The analysis examines the patchwork of federal, state, and international laws governing data privacy and artificial media, highlighting the gaps that allow …
The “I’M Too Much, Yet Never Enough” Paradox: A Critical Approach To Discourses Of Afro-Latinidad Among Second-Generation-Immigrant Women In South Florida, Eleni Victoria Webster
The “I’M Too Much, Yet Never Enough” Paradox: A Critical Approach To Discourses Of Afro-Latinidad Among Second-Generation-Immigrant Women In South Florida, Eleni Victoria Webster
Electronic Theses and Dissertations
This study critically examines discourse and the ways it shapes identities and community belonging for self-identifying Afro-Latina, second-generation-immigrant women in South Florida. This qualitative research uses an intercultural communication framework to analyze interviews and collected poems. Informed by grounded theory and a Black feminist critical approach rooted in the intersectionality theory, the data is analyzed through comparative thematic and metaphorical rhetorical analyses. When discussing the discourses related to the development of ethno-racial identities for Afro-Latinas, certain communicative patterns of self-discovering, self-defining, and self-envisioning emerged. With regard to community belonging, three metaphorical discourses arose: not-enoughness, in-betweenness, and un-humanness. The internalization of …
The Edmonton Obesity Staging System For Pediatrics (Eoss-P) In Mexican Children And Adolescents Living With Obesity: Beyond Bmi Obesity Classes, Isabel Omaña-Guzmán, Roberto Carlos Rodríguez Quintero, Arturo Ruíz-Arroyo, Edith Prado Díaz, Juan Carlos Lopez Alvarenga, Ana María Hernández López, Zendy Fuentes Corona
The Edmonton Obesity Staging System For Pediatrics (Eoss-P) In Mexican Children And Adolescents Living With Obesity: Beyond Bmi Obesity Classes, Isabel Omaña-Guzmán, Roberto Carlos Rodríguez Quintero, Arturo Ruíz-Arroyo, Edith Prado Díaz, Juan Carlos Lopez Alvarenga, Ana María Hernández López, Zendy Fuentes Corona
School of Medicine Publications
Background/Objectives: The Edmonton Obesity Staging System (EOSS) was developed to stage the obesity in adult populations. Subsequently, this staging system was designed for pediatric populations (EOSS-P). This study aimed to describe obesity severity using EOSS-P and correlate it with BMI classes in Mexican children and adolescents living with obesity. Methods: This is a cross-sectional analysis carried out with data from school-age children and adolescents living with obesity who were referred to the Pediatric Obesity Clinic at the Child Welfare Unit at the General Hospital of Mexico “Dr. Eduardo Liceaga”. Obesity was staged using the EOSS-P. To evaluate the association between …
Does Preoperative Arthritis Affect The Outcomes Of Superior Capsular Reconstruction? A Systematic Review, Tae-Hoon Park, Hyungsuk Kim, Sukil Kim, Jongin Lee, Gerald R. Williams, Hyun Seok Song
Does Preoperative Arthritis Affect The Outcomes Of Superior Capsular Reconstruction? A Systematic Review, Tae-Hoon Park, Hyungsuk Kim, Sukil Kim, Jongin Lee, Gerald R. Williams, Hyun Seok Song
Rothman Institute Papers
BACKGROUND: The optimal indications for superior capsular reconstruction (SCR) in cases of massive irreparable rotator cuff tears (RCTs) accompanied by degenerative arthritis remain controversial.
METHODS: A systematic review was conducted according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, searching PubMed, Embase (Elsevier), and Google Scholar. Studies were included if they documented Hamada grade and reported clinical and radiographic outcomes after SCR for irreparable RCTs. American Shoulder and Elbow Surgeons (ASES) score, visual analog scale for pain (pVAS), active range of motion, and acromiohumeral distance (AHD) were analyzed.
RESULTS: In all 7 studies, there was no consistent …
Promising Effects Of Car T-Cell Therapy In Refractory Stiff Person Syndrome And A Hopeful Future For All Neuroautoimmunities, Marinos Dalakas
Promising Effects Of Car T-Cell Therapy In Refractory Stiff Person Syndrome And A Hopeful Future For All Neuroautoimmunities, Marinos Dalakas
Department of Neurology Faculty Papers
Chimeric antigen receptor (CAR) T cells are genetically modified T cells expressing CARs, initially developed to recognize tumor antigens and kill cancer cells that evade T-cell recognition. Because of their impressive success in hemato-oncologic malignancies, CAR T cells are being repurposed with redesigned constructs for safety and sustained efficacy to target refractory systemic autoimmune or neurologic diseases. The CD19 CAR T cells-targeting those CD19-positive, antibody-secreting, long-lived plasma cells, and plasmablasts-are now extensively explored in refractory neuroautoimmunities with promising benefits based on case series in patients with myasthenia gravis (MG), stiff person syndrome (SPS), neuromyelitis, myositis, and multiple sclerosis; some patients …
Estrogen And Obesity Synergistically Suppress Protein S Via Hif1Α, Enhancing Thrombosis Potential, Mohammad A. Mohammad, Narender Kumar, Sonali Ghosh, Ashley L. Paysse, Claudia Leonardi, Vijaya Pilli, Ma Lorena Duhaylungsod, Eric Lazartigues, Diana Polania-Villanueva, Sadaf Nouman, Logan A. Barrios, Rima Chattopadhyay, Rafika Yasmin, Alaina Guilbeau, Manoj Kumar, Tina H. Nguyen, Jovanny Zabaleta, Li Li, Luis Del Valle M.D., Mallory T. Barbier, Samarpan Majumder, Laurent O. Mosnier, Samarpan Majumder
Estrogen And Obesity Synergistically Suppress Protein S Via Hif1Α, Enhancing Thrombosis Potential, Mohammad A. Mohammad, Narender Kumar, Sonali Ghosh, Ashley L. Paysse, Claudia Leonardi, Vijaya Pilli, Ma Lorena Duhaylungsod, Eric Lazartigues, Diana Polania-Villanueva, Sadaf Nouman, Logan A. Barrios, Rima Chattopadhyay, Rafika Yasmin, Alaina Guilbeau, Manoj Kumar, Tina H. Nguyen, Jovanny Zabaleta, Li Li, Luis Del Valle M.D., Mallory T. Barbier, Samarpan Majumder, Laurent O. Mosnier, Samarpan Majumder
School of Graduate Studies Faculty Publications
Venous thromboembolism (VTE) is a leading cause of morbidity and mortality, with risk heightened in premenopausal women with obesity or use estrogen-based oral contraceptives. When both risk factors are present, the thrombosis risk increases substantially. Protein S (PS), an essential anticoagulant cofactor, is downregulated by both estrogen and obesity, but the molecular basis for this suppression remains poorly defined. We investigated the effect of estrogen and obesity on PS expression using plasma samples from 157 women stratified by BMI and contraceptive use, alongside 40 mice categorized as lean or obese with or without estrogen pellet treatment. The levels of PS …
Secondary Teachers’ Instructional Strategies And Challenges In Teaching English Language Learners In Mississippi, Megan Cara Morgan
Secondary Teachers’ Instructional Strategies And Challenges In Teaching English Language Learners In Mississippi, Megan Cara Morgan
Walden Dissertations and Doctoral Studies
Mainstream high school teachers in a district in the state of Mississippi have struggled to consistently implement research-based strategies that address the needs of English Language Learners (ELLs). Guided by Echevarría et al.’s sheltered instruction observation protocol (SIOP), the purpose of this basic qualitative study was to explore the instructional practices implemented by mainstream high school teachers at a Title I high school in a Mississippi district that are aligned with research-based practices and the challenges they reported in improving ELL student achievement in mainstream classrooms. Data were collected from semistructured interviews with nine teachers from a Title I high …
Tlr2 Agonism Suppresses Myeloid Leukemogenesis By Reprogramming Leukemia Stem Cells, Michael E. Lawler, Jennifer S. Romer-Seibert, Michael S. Bowman, Ramkrishna Mitra, Christine M. Eischen, Robert L. Bowman, Sara E. Meyer
Tlr2 Agonism Suppresses Myeloid Leukemogenesis By Reprogramming Leukemia Stem Cells, Michael E. Lawler, Jennifer S. Romer-Seibert, Michael S. Bowman, Ramkrishna Mitra, Christine M. Eischen, Robert L. Bowman, Sara E. Meyer
Department of Pharmacology, Physiology, and Cancer Biology Faculty Papers
The consequences of activated innate immune signaling in acute myeloid leukemia (AML) is not well understood. Using ligands directed at the toll-like family receptors (TLR) in models of high-risk AML, we uncover that TLR2 ligands exert unique antileukemic effects that are distinct from other TLRs. Although TLR2 signaling broadly induces inflammatory gene expression in AML cells, at the single-cell level, cell-type-dependent, divergent transcriptional responses coordinate cellular outputs of proliferation, differentiation, cell death, and activation of immune cell function. TLR2 ligands were the only TLR agonists capable of extending survival of AML-bearing mice through leukemia stem cell (LSC) reprogramming that elevated …
Dual Language In Higher Education: Assessing Student Success And Student Experiences, Katherine Christoffersen, Ramsés Ortín, Dania López García, Ming-Tsan Lu, Javier Cavazos Vela
Dual Language In Higher Education: Assessing Student Success And Student Experiences, Katherine Christoffersen, Ramsés Ortín, Dania López García, Ming-Tsan Lu, Javier Cavazos Vela
Writing and Language Studies Faculty Publications
Although long-standing research has documented the many benefits of dual language (DL) education programs in the K-12 setting, there are few studies on the impact of DL in higher education. This study analyzes DL education at a Hispanic-Serving Institution (HSI) where certain classes are taught in Spanish or bilingually across diverse disciplines. In this mixed methods research study, we examine (1) how enrollment in these classes impacts student success through an analysis of cumulative grade point averages, retention, and time to degree and (2) how students perceive these classes through an analysis of course evaluations and surveys responses from current …
Use Of Calcium Modification In Percutaneous Coronary Intervention: A Comprehensive Review, Noyan Ramazani, Ala W. Abdallah, Michael V. Dicaro, Divyansh Sharma, Aditi Singh, Kachon Lei
Use Of Calcium Modification In Percutaneous Coronary Intervention: A Comprehensive Review, Noyan Ramazani, Ala W. Abdallah, Michael V. Dicaro, Divyansh Sharma, Aditi Singh, Kachon Lei
Department of Internal Medicine Faculty Research
Calcified coronary lesions remain a challenge in percutaneous coronary intervention (PCI) in both situations of acute myocardial infarction (MI) and stable coronary syndrome. It significantly increases the risk of procedural complications due to difficulty in equipment delivery, balloon expansion, and stent delivery. Furthermore, stent thrombosis, dissection, perforation, and future in-stent restenosis occur more frequently in calcified coronary lesions, impacting repeat target vessel revascularization and increasing the risk of future MI. With intracoronary imaging (intravascular ultrasound and optical coherence tomography), peri-procedural success for treating calcified lesions has increased significantly. Different modalities of calcium modification techniques have since been introduced. This review …
Intercellular Signaling And Synaptic Deconstruction Uncovered By Single-Cell And Spatial Transcriptomics In An Ad Tauopathy Model, Jeff X. Ji, Brian L. Giles, Surjyadipta Bhattacharjee, Marie-Audrey I. Kautzmann, Alasdair P. Masson, Sonia Do Carmo, A Claudio Cuello, Nicolas G. Bazan
Intercellular Signaling And Synaptic Deconstruction Uncovered By Single-Cell And Spatial Transcriptomics In An Ad Tauopathy Model, Jeff X. Ji, Brian L. Giles, Surjyadipta Bhattacharjee, Marie-Audrey I. Kautzmann, Alasdair P. Masson, Sonia Do Carmo, A Claudio Cuello, Nicolas G. Bazan
School of Medicine Faculty Publications
Alzheimer's disease (AD) is the leading cause of dementia in elderly individuals worldwide; however, all mechanisms leading to disease onset and progression are not well understood. Here, we report brain single-cell multiome and spatial transcriptomics in a transgenic rat model of human-like tauopathy. We have identified new markers of tau-driven AD pathology and provided single-cell evidence for genes implicated in AD. Our findings reveal how tau hyperphosphorylation and aging alter ligand-receptor communication, transcription factor regulatory networks, and specific cellular networks. Notably, we found intriguing changes in cell communication involving glutamatergic transmission and Netrin signaling as a taupathy consequence. Overall, this …
Successful Multi-Author Publication: Responsive Respectful Teamwork And Lessons Learned, Dorette Sugg Welk
Successful Multi-Author Publication: Responsive Respectful Teamwork And Lessons Learned, Dorette Sugg Welk
Biennial Convention (CONV)
When two or more professionals engage in a scholarship project to develop and publish a journal manuscript, numerous questions could be considered at the outset for best outcomes. An international 10-person effort of Sigma colleagues to publish a manuscript followed a general collaborative plan of ten rules for such an initiative (Frassl et al., 2018). The purpose of this presentation is to describe how these rules spawned questions and actions for a successful publication outcome. Lessons learned may also inform others. Being responsive and respectful in an international collaboration supports scholarly productivity.
Questions considered: What journals and impact factors meet …
Cordmilk: Umbilical Cord Milking Versus Early Cord Clamping On Short-And Long-Term Outcomes In Neonates Who Are Non-Vigorous At Birth-Study Protocol Of A Multi-Center, Cluster-Randomized, Crossover-Controlled Trial, S. Yogeshkumar, Sunil S. Vernekar, Sangappa M. Dhaded, Kiran Talekar, Benjamin E Leiby, Rebecca Hartman, Yvonne Vaucher, Nitin Chouthai, Meenakshi Girish, Manish Jain, Shuchi Jain, Seema Parvekar, Vinita Jain, Alka Patankar, Milind Suryawanshi, Manish Tiwari, Manjushri Waikar, Nidhi Nashine, Deepali Ambike, Mahesh Asalkar, Rajesh Kulkarni, Sandhya Haribhaktha, Hemraj Narkhede, Sudha Chaudhari, Milind Kamble, Deepti Shrirame, Balchandra Falke, Seema Mehta, Asha Verma, Sunil Gothwal, Shivaprasad S. Goudar, Richard Derman, Anup Katheria, Zubair H. Aghai
Cordmilk: Umbilical Cord Milking Versus Early Cord Clamping On Short-And Long-Term Outcomes In Neonates Who Are Non-Vigorous At Birth-Study Protocol Of A Multi-Center, Cluster-Randomized, Crossover-Controlled Trial, S. Yogeshkumar, Sunil S. Vernekar, Sangappa M. Dhaded, Kiran Talekar, Benjamin E Leiby, Rebecca Hartman, Yvonne Vaucher, Nitin Chouthai, Meenakshi Girish, Manish Jain, Shuchi Jain, Seema Parvekar, Vinita Jain, Alka Patankar, Milind Suryawanshi, Manish Tiwari, Manjushri Waikar, Nidhi Nashine, Deepali Ambike, Mahesh Asalkar, Rajesh Kulkarni, Sandhya Haribhaktha, Hemraj Narkhede, Sudha Chaudhari, Milind Kamble, Deepti Shrirame, Balchandra Falke, Seema Mehta, Asha Verma, Sunil Gothwal, Shivaprasad S. Goudar, Richard Derman, Anup Katheria, Zubair H. Aghai
Department of Radiology Faculty Papers
BACKGROUND: Facilitating placental transfusion-the transfer of blood from the placenta to the newborn-via delayed cord clamping (DCC) or umbilical cord milking (UCM) at birth has been shown to improve iron stores in healthy term infants and may positively impact long-term neurodevelopmental outcomes. Infants who are non-vigorous at birth and at risk of developing hypoxic-ischemic encephalopathy (HIE) are particularly likely to benefit from placental transfusion. This process may offer neuroprotection by enhancing cardiopulmonary transition, supporting cardiac preload, improving systemic and cerebral perfusion, delivering stem cells and neurotrophic factors, and preventing iron deficiency. While DCC is not currently recommended for non-vigorous term …
Chimes: November 17, 2025, Calvin University
Chimes: November 17, 2025, Calvin University
Chimes
Budget cuts slash programs and faculty: Students react with grief and frustration by Sarah Sparling, Ian Tjoelker & McKenna Wilkinson
Bringing the Cretaceous to Calvin: Dice Museum reveals fossil and student artwork by Ellery Johnson
Recap: 200 students attend administration town hall by Sarah Sparling
Celebrating Calvin's Asian American and international populations by Jorie Cho
Calvin's D1 hockey on hot streak as they climb to #4 in national rankings by Hendrik Beelen & Zach Kern
Spotted turtles find their home on campus by Maya Oeverman
Student Senate allocates four thousand dollars to accessibility and sustainability projects by Ashley Hamons
Radiation Hardness Study Of Finfet And Gate-All-Around Fet Sram, Albert Lu
Radiation Hardness Study Of Finfet And Gate-All-Around Fet Sram, Albert Lu
Master's Theses
Radiation, such as alpha particles or neutrons, is hard to control and can come from sources such as trace impurities or cosmic rays from space. These can then strike a semiconductor device, such as a Static Random Access Memory (SRAM) cell, and cause the SRAM to have its bit flipped. This bit flip is often just a temporary effect and is thus called a single event upset (SEU). Although it is temporary, a bit flip can cause severe consequences, such as affecting program functionality by causing incorrect data to be used. This is made worse in critical environments that need …
Describing The Determinants Of Fluid Prescribing And Fluid Balance Optimization In The Pediatric Intensive Care Unit: A Qualitative Study At A Community Hospital, Salvador Roland Maffei, Graciela Sanabria, Matthew Pesek, Ayse Akcan-Arikan, Satid Thammasitboon, Patrick G Lyons
Describing The Determinants Of Fluid Prescribing And Fluid Balance Optimization In The Pediatric Intensive Care Unit: A Qualitative Study At A Community Hospital, Salvador Roland Maffei, Graciela Sanabria, Matthew Pesek, Ayse Akcan-Arikan, Satid Thammasitboon, Patrick G Lyons
Faculty, Staff and Students Publications
Background: Critically ill children tend to receive fluid volumes exceeding physiologic requirements despite evidence demonstrating harm with increasing net positive fluid balance. However, interventions aimed at optimizing fluid balance have yet to demonstrate significant clinical benefit, likely because there are multiple drivers of this complex problem. In this study, we used qualitative inquiry to describe the current practice at a community pediatric intensive care unit and discover potential barriers and facilitators to clinical practice change.
Methods: We designed a semi-structured interview guide informed by the consolidated framework in implementation research (CFIR) and conducted interviews with attending physicians, dietitians, nurses, nurse …
Multiomic Analysis Reveals A Key Bcat1 Role In Mtor Activation By B Cell Receptor And Tlr9, Rui Guo, Yizhe Sun, Matthew Y Lim, Hardik Shah, Joao A Paulo, Rahaman A Ahmed, Weixing Li, Yuchen Zhang, Haopeng Yang, Liang Wei Wang, Daniel Strebinger, Nicholas A Smith, Meng Li, Merrin Man Long Leong, Michael Lutchenkov, Jin Hua Liang, Zhixuan Li, Yin Wang, Rishi Puri, Ari Melnick, Michael R Green, John M Asara, Adonia E Papathanassiu, Duane R Wesemann, Steven P Gygi, Vamsi K Mootha, Benjamin E Gewurz
Multiomic Analysis Reveals A Key Bcat1 Role In Mtor Activation By B Cell Receptor And Tlr9, Rui Guo, Yizhe Sun, Matthew Y Lim, Hardik Shah, Joao A Paulo, Rahaman A Ahmed, Weixing Li, Yuchen Zhang, Haopeng Yang, Liang Wei Wang, Daniel Strebinger, Nicholas A Smith, Meng Li, Merrin Man Long Leong, Michael Lutchenkov, Jin Hua Liang, Zhixuan Li, Yin Wang, Rishi Puri, Ari Melnick, Michael R Green, John M Asara, Adonia E Papathanassiu, Duane R Wesemann, Steven P Gygi, Vamsi K Mootha, Benjamin E Gewurz
Faculty, Staff and Student Publications
B lymphocytes play major adaptive immune roles, producing antibodies and driving T cell responses. However, how immunometabolism networks support B cell activation and differentiation in response to distinct receptor stimuli remains incompletely understood. To gain insights, we systematically investigated acute primary human B cell transcriptional, translational, and metabolomic responses to B cell receptor (BCR), TLR9, CD40-ligand (CD40L), IL-4, or combinations thereof. T cell-independent BCR/TLR9 costimulation, which drives malignant and autoimmune B cell states, highly induced transaminase branched chain amino acid transaminase 1 (BCAT1), which localized to lysosomal membranes to support branched chain amino acid synthesis and mTORC1 activation. BCAT1 inhibition …
Cultural Innovation Can Increase And Maintain Biodiversity: A Case Study From Medieval Europe, Adam Spitzig, Manfred Rösch, Jessie Woodbridge, Martin Bauch, Piotr Guzowski, Peter Erhart, Ralph Fyfe, Elena Marinova, Adam Izdebski
Cultural Innovation Can Increase And Maintain Biodiversity: A Case Study From Medieval Europe, Adam Spitzig, Manfred Rösch, Jessie Woodbridge, Martin Bauch, Piotr Guzowski, Peter Erhart, Ralph Fyfe, Elena Marinova, Adam Izdebski
School of Geography, Earth and Environmental Sciences
Numerous research efforts have used paleoecological data to reconstruct past biodiversity in Europe. In these projects, researchers have identified increases in biodiversity over the Holocene and hinted at a positive correlation with human population. These are important findings but are not easily translated into effective biodiversity conservation and restoration policy. We argue that, in order to better inform policymaking, studies of past biodiversity dynamics should include analyses of contemporaneous cultural phenomena in order to identify and describe specific anthropogenic drivers of past biodiversity changes. We present an example here, a case study from the Lake Constance region (southwestern Germany), one …
Ptbp1 Variants Displaying Altered Nucleocytoplasmic Distribution Are Responsible For A Neurodevelopmental Disorder With Skeletal Dysplasia, Aymeric Masson, Catherine Gooch, Et Al.
Ptbp1 Variants Displaying Altered Nucleocytoplasmic Distribution Are Responsible For A Neurodevelopmental Disorder With Skeletal Dysplasia, Aymeric Masson, Catherine Gooch, Et Al.
2020-Current year OA Pubs
Polypyrimidine tract-binding protein 1 (PTBP1) is a heterogeneous nuclear ribonucleoprotein primarily known for its alternative splicing activity. It shuttles between the nucleus and cytoplasm via partially overlapping N-terminal nuclear localization (NLS) and export (NES) signals. Despite its fundamental role in cell growth and differentiation, its involvement in human disease remains poorly understood. We identified 27 individuals from 25 families harboring de novo or inherited pathogenic variants - predominantly start-loss (89%) and, to a lesser extent, missense (11%) - affecting NES/NLS motifs. Affected individuals presented with a syndromic neurodevelopmental disorder and variable skeletal dysplasia with disproportionate short stature with short limbs. …
Developing A Genetic Return Of Results Service Core, Jennifer A Mckenzie, Erin Mcroy, Kevin M Bowling, Jorge Luis Granadillo De Luque, Jessica Mozersky, Erin Linnenbringer, Dustin Baldridge, Jonathan W Heusel, Julie A Neidich, Amanda F Cashen, Laura J Bierut, Sarah M Hartz, Christina A Gurnett
Developing A Genetic Return Of Results Service Core, Jennifer A Mckenzie, Erin Mcroy, Kevin M Bowling, Jorge Luis Granadillo De Luque, Jessica Mozersky, Erin Linnenbringer, Dustin Baldridge, Jonathan W Heusel, Julie A Neidich, Amanda F Cashen, Laura J Bierut, Sarah M Hartz, Christina A Gurnett
2020-Current year OA Pubs
Research participants should be informed of genetic test results that could impact their health, particularly when they have expressed interest in receiving such information. Furthermore, the return of genetic test results is essential to improve trust, transparency, and health equity. However, investigators often encounter barriers in returning genetic test results to research participants. We examined genomic research at a large, research-intensive medical school and found less than 6% of protocols included plans to return results to participants. This study describes our development of protocols for returning primary and secondary genetic test results and implementation of a Genomic Return of Results …