Digital Commons Network^™

Automation And Autonomy In The Ivf Laboratory: Concepts And Implications For Embryologists, Jacques Cohen, Gerardo Mendizabal-Ruiz, Giles Anthony Palmer, Giuseppe Silvestri, Mina Alikani

EVMS School of Health Professions Faculty Publications

Automation is regarded as the next phase in the evolution of laboratory IVF. Despite technological advances, most laboratory procedures remain operator-dependent, contributing to variability in performance and outcomes. While automation has improved reproducibility and efficiency in many areas of medicine, its adoption in IVF has been slow. This review examines how automation may be integrated into IVF laboratories through a set of conceptual distinctions. Automation refers to the execution of procedural steps by machine-controlled systems, whereas autonomy describes the degree to which such systems can operate without human intervention. This review distinguishes between static automation, which maintains or monitors the …

Geographic Distribution: Pseudacris Sierra (Sierran Treefrog). Usa: Florida: Escambia Co., Justin A. Anto, Logan P. Cutts, Jakira A. Davis, Dyrana N. Russell, Renee M. Shiska, Kayla L. O. Walker, Louis A. Somma

Papers in Herpetology

No abstract provided.

Developing An End-To-End Ecosystem Model To Inform Management Of Hudson River Estuary And New York Bight Ecosystem, Xiangyan Yang

Electronic Dissertations and Theses, 2010-current

Ecosystem models provide a powerful framework for evaluating complex anthropogenic impacts because they explicitly represent interactions among species and between biological and physical components of ecosystems. Preliminary analyses indicated that increasing temperature is a major driver of shifts in species distributions and biomass within the Hudson River Estuary and New York Bight (HRE-NYB), the focal region of this dissertation. This dissertation develops an end-to-end (E2E) ecosystem modeling framework to investigate the ecological consequences of climate-induced species distributional shifts in this climate-sensitive region. Habitat suitability index models were developed and validated using sea surface temperature as a key thermal indicator to …

Structural And Biochemical Insights Into Phospholipase D Function And Its Small Gtpase Stimulators, Douglas Jay Marr

Electronic Dissertations and Theses, 2010-current

Phospholipase D1 (PLD1) and D2 (PLD2) are lipid metabolizing enzymes that produce phosphatidic acid and contribute to pathologies such as cancer, neurodegeneration, and cardiovascular diseases. Recently, the ARF-like GTPase 11 (ARL11) was identified as an activator of PLD1, but the mechanism of this stimulation remained unknown. Here, we use in vitro biochemical assays and structural predictions to determine that ARL11 interacts with PLD1 using three adjacent, biochemically distinct interfaces, and that the ends of PLD1’s disordered loop form ordered structures to facilitate these interactions. Both PLD1 and PLD2 are peripheral membrane proteins that have differing subcellular localization important for their …

Injectable Borate/Borosilicate Bioactive Glass Systems For The Regeneration Of Hard Tissue – A Critical Review Of The Literature, S. Sina Mohammadi, Sunjeev S. Phull, Ryan J. Gilbert, Mark R. Towler

Chemical and Biochemical Engineering Faculty Research & Creative Works

Bone defects caused by trauma, infection, or tumor resection remain difficult to treat because successful repair requires both structural restoration and control of the local pathological microenvironment. Osteolysis, defined as pathological bone resorption, is central to many of these conditions and is commonly driven by excessive osteoclast activity. Clinically translated injectable products such as NovaBone® Putty demonstrate the value of moldable bioactiveglass grafts for defect filling; however, conventional silicate bioactive glasses are permanent and provide limited therapeutic ion release. This limitation has motivated the development of injectable borate bioactive glass (B-BGs) and injectable borosilicate bioactive glass (BS-BG) systems as more …

Visible At Last: Legal Recognition Of Children Born Of War (Cbow) And The Case Of Bosnia And Herzegovina, Ajna Jusić, Gordana Subotić Ph.D.

Human Rights Brief

Children born of war (CBOW) — those conceived through conflict-related sexual violence— have long remained stigmatized, marginalized, and largely invisible in law and policy. Drawing on international scholarship and Bosnia and Herzegovina’s post-conflict experience, this Article examines the social, political, and legal mechanisms that sustain CBOW exclusion and traces the emergence of CBOW as a recognized category within contemporary international legal frameworks. Using Bosnia and Herzegovina as a case study, the Article argues that patriarchal norms, fragmented governance and legal structures, and decades of institutional silence have profoundly shaped CBOW lived experiences and access to rights. Furthermore, the Article assesses …

T.H. V. The Czech Republic: A Step Forward Or Back For Lgbtq+ Rights And Discourse In Europe With The First Openly Non-Binary Applicant?, Katherine Olsson

Human Rights Brief

On December 9, 2025, the European Court of Human Rights (ECtHR) issued a final judgment in the case of T.H. v. The Czech Republic.  The case concerned a non-binary individual, T.H., who was assigned male at birth and, since May 2012, had repeatedly petitioned to change their sex/gender marker and personal numerical code on their national identity card.  Because the Czech system does not provide for the option of a neutral gender marker, T.H. petitioned to have their registered gender changed to female.

The Doctor Won't See You Now: Legal Proscriptions For Medical Tourism Control And Regulation, Shenley W. Wish

Case Western Reserve Journal of International Law

The Medical Tourism industry has experienced remarkable growth in the past decade and is tracking to exceed that growth dramatically in the coming decade. With this rapid expansion, however, comes growing pains—predominantly lackluster patient safety. This Note examines the opportunities and challenges that would arise from regulating Medical Tourism through an international treaty, recognizing that an international treaty approach provides the most comprehensive and practically feasible solution for addressing complex cross-border constraints to create a safer global medical industry. (from the author)

Corporate Culpability And The Tragedy Of The Commons: Extraction And Enforcement Schemes In Brazil And Nigeria, Jane Ijeoma Onuoha

Emory International Law Review

Natural resources that were abundant decades ago are now at an all-time low. Meanwhile, corporations continue to benefit from using the Earth and its resources for their profit. Rather than enforcing established legal frameworks designed to protect the environment and human rights, governments often allow corruption, control, and competition to create opportunities for gain through complicity. In countries like the Federative Republic of Brazil and in the Federal Republic of Nigeria, the effects of inaction are taking a toll on the natural resources that each country relies on. Multinational corporations are not held accountable for their corrupt and illegal extractive …

Full Journal

Pastoral Liturgy

No abstract provided.

Stem Cell-Derived Developmental Models For Translational Evaluation Of Disease And Therapy, Maria B. Paredes-Espinosa

Electronic Theses & Dissertations (2024 - present)

Human development as well as congenital and adult diseases emerge from coordinated interactions among multiple cell types, regulatory programs, and tissue compartments that remain largely unresolved. Conventional simple lineage-restricted in vitro systems poorly capture this complexity. My dissertation uses human stem cell-derived developmental models to study human cardiac morphogenesis and heart diseases and application of a networked neuron platform to explore senescence-associated neurodegeneration impact on Alzheimer’s neurons.

Elongating multi-lineage organized cardiac (EMLOC) gastruloids are a synthetic embryology model that co-generates contractile cardiomyocyte populations alongside mesenchymal, endothelial, epicardial-like, neural crest-associated, and neuronal cells within a shared in vitro developmental environment. Single-cell …

Next-Generation Computing Hardware: Advancements In Tantalum Oxide Reram For Ai And Neuromorphic Applications, Rajas Ravindra Mathkari

Electronic Theses & Dissertations (2024 - present)

The rapid development of artificial intelligence, machine learning, and data-intensive computing has exposed the fundamental limitations of conventional von Neumann architectures, in which energy and time are continuously lost transferring data between physically separate memory and processing units. In contrast, the human brain performs complex computations directly at the point of memory storage through billions of parallel synaptic connections, a paradigm known as in-memory computing. Realizing this in hardware requires memory devices that are fast, energy-efficient, non-volatile, and capable of storing multiple resistance levels in an analog manner. Resistive Random Access Memory (ReRAM) based on tantalum oxide (TaOx) is one …

The Chemistry Of Red Lipstick: The Impact Red Lipstick Has On Society, Lilliana Weldeslassie

Electronic Theses & Dissertations (2024 - present)

Cosmetic chemistry is deeply embedded in everyday life, shaping the products people use from morning to night. Among these, red lipstick stands out as a formulation that blends complex chemistry with a cultural meaning. This thesis examines the scientific foundations of red lipstick through its chemical composition, pigment structure, toxicological history, analytical methods, and evolving sustainability practices. Historically, red lipsticks relied on high-risk ingredients such as lead, mercury, and other toxic metals, reflecting an era before chemical safety and regulatory oversight were incorporated.²¹ Modern formulations have established safer synthetic dyes, natural waxes, plant-based oils, and stabilizers created to optimize …

Multifunctional And Adaptive: Tracking How Fibroblasts Respond To Tissue Injury And Facilitate Tissue Remodeling, Joey R. Tavarez

Electronic Theses & Dissertations (2024 - present)

Fibrosis is characterized by an accumulation of proteins in the extracellular matrix (ECM) that results in altered tissue architecture and reduced organ function. In the salivary glands, fibrosis leads to loss of saliva, dysbiosis of the oral microbiome, an increase in oral infections, difficulty in digestion of food and an overall reduction in the quality of life. Understanding the progression of fibrosis and how it affects human health is a crucial step for designing effective therapeutics. Understanding fibroblast function is integral to advancing the field due to the many roles they play in maintaining the ECM. To perform preliminary analysis, …

Constructing The Political “Other”: Affective Polarization And Cross-Ideological Portrayals On Instagram, Amanda M. Novellin

Electronic Theses & Dissertations (2024 - present)

Instagram has frequently been characterized by users as a platform that permits the circulation of hostile and adversarial political content due to comparatively limited moderation practices. In January 2025, Meta CEO Mark Zuckerberg announced changes to content moderation policies on Facebook and Instagram, including the removal of third-party fact-checking mechanisms. These platform-level changes further reshaped the political information environment in which online discourse occurs. However, even prior to these policy changes, Instagram had established itself as a prominent space for highly polarized political expression across the ideological spectrum.

This thesis examines how political polarization in the United States is reflected …

Psychometric Assessment Of The Facilitative Systemic Intervention Skills Rating System– Spanish Version, Sarah J. Crosky

Electronic Theses & Dissertations (2024 - present)

Despite the growing understanding of therapist factors in client outcomes, there remains limited understanding of the skills that distinguish effective family therapists. The aim of the present study was to assess the interrater reliabilities and factorial structure of a Spanish version of the Facilitative Systemic Intervention Skills (FSIS; Jones et al., 2023a), an observational rating system for evaluating the skillfulness of family therapists in delivering systemic interventions. The FSIS includes eight empirically and theoretically informed systemic therapy skills (Inclusiveness, Empathy for Relational Difficulties, Responsiveness to Safety Concerns, Collaborative Stance, Conceptualizing Family Problems Systemically, Responsiveness to Disparate Goals, Focus on Family …

Enhancing The Recovery Of Threatened And Endangered Shorebird And Plant Species In Southampton, New York: A Structured Policy Analysis Approach, Joann Smith

Electronic Theses & Dissertations (2024 - present)

Settled on the eastern end of the most human populated island in North America, Long Island, New York, is the Town of Southampton. The Towns’ Board of Trustees are responsible for the management of federal or state listed species, which they carry out through their Threatened and Endangered Species Program (T&E program). Currently the program manages two listed shorebirds and two listed seabeach plants; the Piping plover (Charadrius melodus), a federally threatened species, and the Least Tern (Sternula antillarum), a New York State threatened species, Seabeach amaranth (Amaranthus pumilus), both federal and state threatened, and …

A Low-Cost Fourier-Based Dual-Pump Mock Circulatory Loop For Arterial Pressure Waveform Reproduction, Victor K. Tsui, Kouhyar Tavakolian, Daniel Ewert

Electrical & Computer Engineering Faculty Publications

Cardiovascular diseases are among the leading causes of death worldwide, creating a need for reliable hemodynamic testing platforms for cardiovascular device evaluation and therapeutic development. Mock circulatory loops (MCLs) provide effective in vitro platforms for reproducing physiological and pathological pressure conditions; however, many existing systems remain limited in programmability, waveform fidelity, standardization, and affordability. This study presents a cost-effective dual-pump hybrid MCL (hMCL) that independently regulates baseline and pulsatile pressure components using Fourier-based harmonic synthesis. Reference arterial pressure waveforms were decomposed into harmonic components, and their amplitudes, frequencies, and phase shifts were converted into pulse-width-modulation signals for dual-pump actuation. Validation …

Deep Learning Assisted Time-Resolved Optical Imaging For Surgical Guidance And Radiotherapy, Shiru Wang

Dartmouth College Ph.D Dissertations

Image-guided therapy enables clinicians to monitor treatment progress, verify accurate delivery, and make immediate adjustments. Among various imaging modalities available for this purpose, optical imaging techniques offer distinct advantages for real-time guidance through their non-ionizing nature and high temporal resolution. However, light propagation in biological tissue fundamentally limits these imaging modalities by obscuring spatial information and introducing noise artifacts. These physical constraints make it hard to accurately interpret subsurface structures and compromise the reliability of real-time guidance.

This thesis develops deep learning methods to overcome these limitations in two distinct optical imaging modalities. The first approach aims to improve time-of-flight …

Engineering Plga Nanoparticle Size To Modulate Immune Responses After Spinal Cord Injury, Daniel J. Kolpek

University of Kentucky Doctoral Dissertations

Spinal cord injury is a severe and debilitating condition that often results in lifelong complications, including paralysis. Many of these chronic outcomes are driven by a sustained inflammatory response at the injury site, which limits tissue regeneration and functional recovery. As a result, therapeutic strategies that modulate this immune response have gained significant interest. Polymer based nanoparticle therapies have emerged as a promising approach due to their ability to interact with and influence immune cell behavior. Importantly, the physicochemical properties of nanoparticles can be precisely tuned to optimize these effects. Among these properties, size has been shown to influence key …

Recirculated Submarine Groundwater Discharge Dominates Nutrient Inputs And Enhances Eutrophication Risk In A Coastal Lagoon, Júlia Rodriguez-Puig, Clara Ruiz-González, Marc Diego-Feliu, Irene Alorda-Montiel, Aaron Alorda-Kleinglass, Daniel Romano-Gude, Andrea G. Bravo, Júlia Dordal-Soriano, Javier Gilabert, Sophia Bergeler, Celine Lavergne, Gemma Casas, Marisol Manzano, Jordi Garcia-Orellana, Valentí Rodellas

OES Faculty Publications

Submarine groundwater discharge (SGD) is a widely recognized pathway for nutrient transport to coastal systems. Prior studies overlook the unique biogeochemical signatures of different SGD pathways, neglecting their differences in biogeochemical transformations and spatiotemporal factors. Here, we present an integrated assessment of nutrient delivery through three SGD pathways (fresh SGD, long‐scale recirculated SGD, and short‐scale porewater exchange), alongside surface water inputs, to evaluate their seasonality and impact on nutrient dynamics in a coastal lagoon. We conducted five field surveys in March, July, and November 2021, July 2024, and March 2025 in the Mar Menor lagoon, an ecosystem facing severe ecological …

Visualizing The Barely Detectable: Particle Characteristics Of The Elusive Aquatic Gel Phase In The Northeastern Subtropical Atlantic, Huanqing Huang, María Couret, Santiago Hernández-León, Alexander B. Bochdansky

OES Faculty Publications

Marine gels constitute a large yet poorly explored ocean carbon pool. Shadow imaging was tuned to detect particles at two sensitivity levels: high–optical density particles (HODP), resembling the particles captured by most imaging systems, and low–optical density particles (LODP), representing a vastly more abundant and gel-dominated pool. This method enabled us to map and characterize a portion of oceanic gels without filtration and staining. In the subtropical northeast Atlantic, LODP outnumbered HODP of the same size by one or two orders of magnitude. Morphology and particle number spectra differed greatly between the two pools, with LODP showing greater morphological homogeneity …

Plasma Proteomic Profile Of Dietary Potassium And Incident Ckd, Bing Yu, Casey M Rebholz

Faculty, Staff and Student Publications

Background:: There is a need for objective biomarkers of dietary potassium. The mechanisms through which dietary potassium influences kidney health are incompletely understood.

Methods:: Atherosclerosis Risk in Communities study participants at visit 3 (1993–1995) with dietary and proteomics data were randomly divided into discovery (N=6,814) and replication (N=3,380) sets. We examined associations between dietary potassium and 4,955 aptamers using multivariable linear regression, adjusting for sociodemographic factors, health behaviors, and estimated glomerular filtration rate, with a false discovery rate of 0.05. Then, we tested the prospective associations between potassium-related proteins and incident chronic kidney disease (CKD).

Results:: …

Latent Classification Of Time-Dependent Transition Rates In Longitudinal Binary Outcome Data

Faculty, Staff and Student Publications

Continuous-time Markov chain (CTMC) models and latent classification methods are commonly used to analyze longitudinal categorical outcomes in medical research. While CTMC models are popular for their simplicity and effectiveness, their assumption of constant transition rates presents limitations in capturing dynamic behaviors. To address this, non-homogeneous continuous-time Markov chains (NH-CTMCs) have been developed, incorporating time-varying transition rates to enhance model flexibility. In this study, we leverage closed-form transition probabilities for a fully ergodic two-state NH-CTMC model and propose a latent class clustering approach to identify heterogeneous transition rate patterns within the population. We emphasize the potential advantages of these models …

Nasal Cavity Microbial Makeup And The Influence On Psychiatric Symptoms Following Fire Exposure In Firefighters, Janis Campbell, Joseph F Petrosino, Jooyeon Hwang

Faculty, Staff and Student Publications

Background: Firefighters experience high levels of occupational stress and trauma, increasing their risk of depression, anxiety, and post-traumatic stress disorder (PTSD). Although microbial communities may influence brain function and behavior through neural pathways, the nasal microbiome remains understudied. This study examined associations between nasal microbiome characteristics and psychiatric symptoms among firefighters.

Methods: We conducted a cross-sectional study of 34 firefighters recruited from Texas fire stations. Participants completed validated questionnaires assessing depression, anxiety, and PTSD. Nasal swabs were collected before and after fire suppression and 16S rRNA sequencing was used to characterize microbial communities. Alpha and beta diversity, relative abundance, and …

Improving Overall Risk Ranking Via Subgroup-Level Information Borrowing In Survival Risk Stratification

Faculty, Staff and Student Publications

Effective risk stratification is essential for providing tailored therapies, improving patient outcomes, and optimizing healthcare resources by identifying sub-populations with similar health risks. However, accurate risk ranking is challenging in the presence of heterogeneous subgroups. Under these instances, subgroup-level information can be leveraged to refine the overall risk ranking. We propose a novel approach that integrates within-subgroup risk ranking percentiles to enhance the overall cohort risk stratification. This method uses both a global model and subgroup-specific models along with optimized weights to improve discriminatory performance across the entire cohort. The proposed method is validated through extensive simulations and applied to …

Civil Litigation Notes, Arthur S. Leonard

Other Publications

No abstract provided.

4th Circuit Rules That West Virginia’S Medicaid Coverage Exclusion Of “Sex-Change” Surgery Is Legal, Arthur S. Leonard

Other Publications

No abstract provided.

Developing A Best Practice Guideline For Clinical Practice In A Digital Health Environment: Systematic Reviews Based On The Grading Of Recommendations, Assessment, Development, And Evaluation Approach, Lauren Bailey, Lyndsay Howitt, Nafsin Nizum, Christine Buchanan, Maureen Charlebois, Jennifer Yoon, Rob Beleno, Michelle Beyn, Rebecca Bliss, Elizabeth Borycki, Margarita Cleghorne, Sandra Davidson, Lorie Donelle Phd, Rn, Fcan, Faan, Alexander Hamilton, Tsz Yee Ip, Margery Konan, Daile Moffat, Sanaz Riahi, Tiziana Rivera, Tammy Rooke, Vaishali Sengar, Steve Sottile, Meredith Whitehead, Vanessa Burkoski

Publications

Background:

Digital health refers to the field of knowledge and practice associated with the development and use of digital technologies to improve clinical practice and health outcomes. Knowledge of digital health technology is becoming essential for all nurses and health providers.

Objective:

This study aims to present the results of the systematic reviews that were used to inform the recommendations in a best practice guideline (BPG) following the GRADE (Grading of Recommendations, Assessment, Development, and Evaluation) approach. Reviews focused on digital health education for nurses and health providers, peer champion models, and the use of predictive analytics in digital health …

Thinking Machines: Cybernetics, Artificial Intelligence, And Technological Anxiety In The American Cold War, Erin Mae Wilcox

Theses and Dissertations

Following the Second World War, cybernetics emerged as a cross-disciplinary study in philosophy, neurophysiology, electrical engineering, and mathematics. Cyberneticists proposed the formal study of the man-machine analogy; that is, to equate biological structures to a complex mechanical system. Drawing from this analogy, cyberneticists used programmable digital computers to emulate the functions of the human brain. The study of artificial intelligence emerged within this cybernetic discourse in the early 1950s; yet, by the mid-1960s, the two disciplines suffered a methodological fracture. Drawing from a tradition generated by this fracture, historians have traditionally examined cybernetics and artificial intelligence in isolation from one …