Digital Commons Network^™

Artificial Intelligence: A Double-Edged Sword In Support And Subversion Of The Biological Weapons Convention; Part One: Framing The Issues, Elise Annett, Diane Dieuliis, James Giordano

Strategic Insights

This commentary explores how artificial intelligence (AI) is profoundly affecting the biological enterprise, serving both as a powerful tool for scientific advancement and as a potential vector for misuse. The authors explain that AI can accelerate research, improve diagnostics, and enhance biodefense, but it also lowers barriers to creating or modifying biological agents and can be exploited for harmful ends. The dual effects make AI a "double-edged sword" that challenges existing governance, detection systems, and deterrence frameworks in biosecurity. Responsible integration of AI into biology requires policies that balance innovating with safeguards, strengthened international cooperation, and adaptive oversights to ensure …

Mitochondrial Insoluble Aggregates In Aging And Alzheimer’S Disease Models: Cross-Species Proteomic Integration, Identification Of Conserved Candidates, And Pharmacological Disruption Of Eef-2 Interactions, Sonu Pahal

Theses and Dissertations

Protein aggregation within mitochondria emerges early in both aging and Alzheimer’s disease (AD) and contributes to progressive loss of proteostasis. Insoluble mitochondrial aggregate fractions from Caenorhabditis elegans revealed extensive enrichment of metabolic and translational proteins that also appear in human Alzheimer hippocampal aggregates. Comparative analysis across age and genotype identified a conserved subset of aggregation-prone proteins, several of which cluster around elongation factor 2 (eEF-2), a regulator of ribosomal translocation and energy coupling. Cross-species integration defined a network in which eEF-2 links chaperones, metabolic enzymes, and RNA-binding proteins that co-aggregate in both human Alzheimer material and nematode models. Functional tests …

Improving Skin Cancer Knowledge And Screening Among Older Chinese Americans Males, Yan Wang, Anne Derouin, Barbara Turner, Hanzhang Xu

Biennial Convention (CONV)

Skin cancer is the most common cancer in the U.S. with more than 5 million cases diagnosed annually. It is estimated that about 1 in 5 Americans will develop skin cancer by the age of 70, a prevalence that has been increasing annually (Adams et al., 2021; Aggarwal et al., 2021; Dildar et al., 2021; Trager et al., 2022). As reported by the ACS, men are more likely to develop melanoma compared to women. At the age of 80, men are three times more likely to develop melanoma than women, nearly double the number of male deaths due to the …

Side Effects Of Antipsychotics Impacting The Revolving Door Of Admissions At The Bellevue Hospital, Sandra Lorraine Chisholm-Ford

Biennial Convention (CONV)

Background: Antipsychotic medications are very effective in mitigating the symptoms associated with schizophrenia. However, patients receiving these medications often develop side effects with therapy. Side effects to antipsychotic medications is a global problem resulting in non-compliance, relapse, and re-hospitalizations.

Objectives: The study aimed to identify the prevalence of adverse reactions and side effects experienced by patients with schizophrenia taking antipsychotic medication, as well as the prevalence of readmissions to the Bellevue Hospital due to medication noncompliance.

Methods: A descriptive cross-sectional survey was done among forty-four patients diagnosed with schizophrenia admitted to acute and sub-acute care wards at the Bellevue Hospital. …

Turning Setbacks Into Strength: Developing The Emerging Concept Of Reclaiming Power, Nadine Cesaire

Biennial Convention (CONV)

Reclaiming power represents a transformative journey where individuals restore autonomy, resilience, and intentional participation in life. This concept emphasizes a shift from disconnection and diminished engagement to active involvement in personal growth and change. It redefines setbacks as opportunities for self-discovery, fostering openness to life’s unpredictability and challenges.

Substance Use Disorder (SUD) affects 14.5% of individuals aged 12 and older in the United States, equating to 48.7 million people (SAMHSA, 2023). This chronic condition, characterized by compulsive substance use, often leads to cycles of recovery and relapse. Overdose deaths rose by 50.9% between 2019 and 2022 (CDC, 2023), with relapse …

Space Agriculture: A Comprehensive Systems-Level Review Of Challenges And Opportunities, Hassan Fazayeli, Aaron Lee M. Daigh, Cassandra Palmer, Santosh Pitla, David Jones, Yufeng Ge

Biological Engineering Faculty Publications

As humanity prepares for prolonged space missions and future extraterrestrial settlements, developing reliable and resilient food-production systems is becoming a critical priority. Space agriculture, the cultivation of plants beyond Earth (particularly on the Moon and Mars), faces a constellation of interdependent environmental, biological, and engineering challenges. These include limited solar radiation, elevated ionizing radiation, large thermal variability, non-Earth atmospheric pressures, reduced gravity, regolith substrates with low nutrient-holding capacity, high-CO₂/low-O₂ atmospheres, pervasive dust, constrained water and nutrient availability, altered plant physiology, and the overarching need for closed-loop, resource-efficient systems. These stressors create an exceptionally challenging environment for plant …

Chimes: December 8, 2025, Calvin University

Chimes

Women's volleyball's memorable season ends in the DIII quarterfinals by Zach Kern

Facilities expands recycling program on campus by Ian Tjoelker

A history of the liberal arts at Calvin: 1890s to today by McKenna Wilkinson

Christmas beyond Calvin: Letters to Santa by Ellery Johnson

"Energy and vision": Calvin's Black Student Union by Jorie Cho

Running with Sophie by Evangeline Anga

Students prepare for upcoming Fall Film & Media Showcase by Ashley Hamons

Spike Timing Depended Plasticity Produces Unsupervised Learning Of Synergistic Muscle Feedback In A Synthetical Neural Network, Mark Allen Pupkiewicz

Dissertations and Theses

This study investigates how type Ia feedback from muscle spindles can be organized into groups representing agonistic muscle pairs through Spike Timing Dependent Plasticity (STDP). A single degree of freedom joint is actuated with four biologically modeled muscles forming two agonistic pairs. In order to emulate the sensory dynamics of biological muscle spindles, sensors in the model record the active length and velocity states of each muscle, the two primary factors eliciting type Ia afferent responses. In biological networks, synapses from Ia sensory neurons frequently activate interneurons representing agonistic muscle sources. This research investigates whether this organization can emerge in …

Polycystin-2 Is Cardioprotective Against Myocardial Infarction By Regulating The Calcium-Mediated Er-Stress Response, Virdjinija Vuchkovska

Dissertations

Patients with autosomal polycystic kidney disease (ADPKD) have an increased risk and worse outcomes after acute myocardial infarction, but the mechanism for this is unknown. Polycystin 2 (PC2), one of the two main proteins mutated in ADPKD, is a calcium permeant channel that localizes to the ER/SR. In non-cardiac cells, PC2 regulates the unfolded protein response (UPR) pathway under ER stress. However, whether PC2 is cardioprotective against ER stress is unknown. We found that PC2 expression increased in cardiomyocytes from human ischemic hearts and infarcted murine hearts. Cardiomyocyte-specific PC2 KO (PC2 KO) mice had worsened cardiac function after myocardial infarction …

Using Light To Dissect Mechanisms Of Septin Recruitment, Shreya Chandrasekar

Dissertations

Cells interpret biochemical and mechanical signals through dynamic regulation of the cytoskeleton and adhesion complexes, enabling key processes such as shape adaptation, force generation and migration. As these signals vary in both time and space, they can be challenging to resolve using traditional bulk assays. To overcome this limitation, we employ light-based optogenetic tools to reversibly modulate biochemical signals and mechanical equilibrium within cells. Specifically, we use the iLID optogenetic approach to locally activate signaling and manipulate contractility within the cytoskeleton for the purpose of investigating the role of RhoA and contractility on septin organization and adhesion protein localization. We …

Imaging Reactive Oxygen Species With L-012 Reveals Neutrophil Extracellular Trap Formation In Pancreatic Ductal Adenocarcinoma, Angisha Basnet, Kaitlyn M Landreth, Michael Sestito, Kristen Ranson, Seth T Gammon, David Piwnica-Worms, Brian A Boone, Tracy W Liu

Faculty, Staff and Student Publications

Neutrophils, key effector cells of the innate immune system, combat pathogens through mechanisms including the production of reactive oxygen species (ROS) and the release of neutrophil extracellular traps (NETs). While these responses are critical for host defense, prolonged elevation of ROS and dysregulated NETosis mediated by neutrophils have been implicated in autoimmune diseases, chronic inflammation, and cancer. In pancreatic ductal adenocarcinoma (PDAC), a highly aggressive and inflammatory malignancy, an increase in neutrophils infiltrating the tumor microenvironment promotes cancer progression and metastasis through increased ROS production and NET release. Using bioluminescence imaging with the reporter L-012 and NET assays, we assessed …

Towards A Typology Of Mental Health Crisis Care Services For Children And Young People In England And Wales: A Cross-Sectional Survey And Analysis Of Implementation Practices, Clare Bennett, Claire Fraser, Ben Hannigan, Leanne Sawle, Jessy Williams, Aled Jones, Steven Pryjmachuk, Mair B. Elliott, Martin Elliott, Nicola Bennett, Euan Hails, Iain Mcmillan, Rachael Vaughan

School of Nursing and Midwifery

Background: The mental health and wellbeing of children and young people is a global concern. Alongside approaches emphasising mental health promotion in schools, communities and in the home, many countries are also investing in crisis services. These aim to meet the needs of young people experiencing acute psychosocial distress. A recent synthesis of the international evidence found a paucity of research in this area. This study sought to address this gap while simultaneously situating the findings within the international context and drawing out implications for policymakers and practitioners. Methods: A cross-sectional study aiming to describe and map approaches to the …

Thriving Hives: The Apiary - Beekeeping Essentials, Joseph Okoh, Andree' Walker Bravo

All Current Publications

This fact sheet is designed to help honey bee producers optimize their beekeeping practices and improve management systems. It offers essential guidance on selecting an ideal apiary location, choosing the right beehive, and ensuring efficient colony management. Additionally, this document serves as a valuable training resource for aspiring beekeepers.

Wf-2453 Post-Wildfire Hydrogeomorphic Risk Management Assessment, Belize A. Lane

Funded Research Records

No abstract provided.

The Compatibility And Contribution Of Natural Enemies In Western Us Alfalfa Management, Ricardo A. Ramirez, Scott A. Bernhardt, Ryan A. Larsen

Funded Research Records

No abstract provided.

Collaborative Research: Cif: Medium: Foundations Of Robust Deep Learning Via Data Geometry And Dyadic Structure, Kevin Moon

Funded Research Records

No abstract provided.

Exploration Of The Microbiome Of Native Plants For Plant Growth-Promoting Microbes To Mitigate Effects Of Abiotic Stresses In Crop Plants, Amita Kaundal

Funded Research Records

No abstract provided.

Collaborative Research: Seed-Fungal Interactions: Uncovering Functional Specificity And Primary Symbionts As Key Drivers Of Tropical Tree Recruitment, Noelle Beckman

Funded Research Records

No abstract provided.

Collaborative Research: Evolving Thicker Skin: Understanding How Adaptations To A Universal Trade-Off Dictate The Climate Vulnerability And Ecology Of An Imperiled Vertebrate Clade, Molly Womack

Funded Research Records

No abstract provided.

Harnessing Blueberry Flower Chemistry And Morphology To Boost Pollination And Bee Health, Monica Borghi

Funded Research Records

No abstract provided.

Investigation Of The Endogenous Opioid Neural Circuitry In Pain, Erin Nicole Bobeck

Funded Research Records

No abstract provided.

Myocardial Lipin1 Protects The Heart Against Ischemic Injury By Preserving Lipid Homeostasis, Jiaxi Guo, Brian N. Finck, Et Al.

2020-Current year OA Pubs

Impaired cardiac lipid metabolism has been reported to cause heart failure. Lipin1, a multifunctional protein, is a phosphatidate phosphatase that generates diacylglycerol from phosphatidic acid and a transcriptional cofactor that regulates lipid metabolism-related gene expression. Here, we investigated the roles of lipin1 in cardiac remodeling after myocardial infarction (MI). The expression levels of lipin1 significantly decreased in cardiomyocytes of the human failing heart and murine ischemic myocardium. Cardiomyocyte-specific Lpin1 knockout (cKO) mice showed left ventricle enlargement and reduced fractional shortening after MI, compared with control mice. This was accompanied by elevated cardiac fibrosis, accumulation of reactive oxygen species, and increased …

Elephant In The Classroom: How Ethical Ai Can Improve Student Success, Ibrahim Kocaman, Daniel A. Cutrer

Publications

The integration of artificial intelligence (AI) into teaching and learning in higher education without compromising academic integrity is a pressing issue. To make the benefits of generative AI (GenAI) available to students while upholding principles of ethics and academic honesty, the authors implemented an ethical use of AI policy in their Introduction to Research Methods at Embry-Riddle University. The authors hypothesized and found that allowing ethical utilization of AI would lead to higher student engagement and academic success. These findings offer valuable insights for higher education programs and educators, particularly in security studies.

Southern Adventist University Commencement Winter 2025, Southern Adventist University

Commencement Programs

Program for Southern Adventist University Winter 2025 graduation. The commencement service took place on December 18, 2025 at 7 pm in Iles Physical Education Center.

Buffer Vs. Swabs: Efficacy Of Carrier Nucleic Acids In Robotic Extractions, Shawn Cecil

Honors Projects

This study compared the efficiency of two carrier nucleic acid methods, specifically using salmon sperm DNA (spDNA), in robotic solid-phase extractions of cotton swab samples. Robotic extractions reduce processing time and workload but result in substantially lower DNA recovery than manual organic extraction. This research tested 10 µg of spDNA being added to the lysis buffer or pre-treating the swabs with it before DNA was added. Both methods showed a significant increase in recovery compared to extractions with no carrier. In the buffer extractions, recovery ranged from 69.4% to 117.5% and the swabs being pre-treated ranged from 84.2% to 125.8% …

Epidemiology, Presentation, And Diagnosis Of Type 2 Diabetes Mellitus In Children And Adolescents, Bisher Alsabbagh, Whard Alsabbagh

School of Integrative Biological & Chemical Sciences (Formerly Dept. of Biology)

The prevalence of type 2 diabetes mellitus (T2DM) in children and adolescents has increased substantially over recent decades, paralleling rising rates of pediatric obesity and metabolic risk. Youth-onset T2DM is characterized by significant insulin resistance accompanied by an inadequate compensatory insulin response, resulting in progressive hyperglycemia and early beta-cell dysfunction. Incidence varies widely among racial and ethnic groups, with the highest rates observed in non-Hispanic Black, Hispanic, Native American, Asian American, and Pacific Islander youth. Risk factors include obesity, family history, high-risk ethnicity, pubertal insulin resistance, prenatal metabolic exposures, and comorbid conditions such as polycystic ovary syndrome. Clinical presentation ranges …

Executive Function Among Older Adults With Bipolar Disorder: A Gage-Bd Analysis, Federica Klaus, Martha Sajatovic, Peijun Chen, Nicole Fiorelli, Ashley N. Sutherland

Faculty Scholarship

Objectives Executive function deficits in bipolar disorder (BD) are major contributors to disability in older age BD (OABD). We investigated the difference between OABD and age-equated healthy comparators (HC); and, in the OABD group, the associations of executive function with age, symptom severity, global cognition, and daily functioning. Design Cross-sectional analysis of executive function in OABD versus HC. Setting Analysis of large archival dataset harmonized from 12 international OABD studies. Participants Older adults (≥50 years) with OABD ( n = 614) and HC ( n = 192). Measurements Executive function was assessed via Trail Making Test B (TMT-B) completion time; …

Investigating Factors That Affect Total Ige Antibody Levels Of A Canine Population In Louisville, Ky, Iris N. Gillespie

Undergraduate Theses

Canine atopic dermatitis (CAD) is a genetically predisposed condition that causes inflammatory and pruritic (itchy) skin reactions in response to environmental and food allergens. The main purpose of this study is to determine if there is a correlation between pollen counts and total canine IgE antibody levels of dogs living in Louisville, KY. Additionally, data is analyzed to look for trends documented in previous studies related to the impacts of sex, age, and allergic symptoms on total IgE count. In collaboration with the Downtown Animal Hospital, blood samples were drawn from 16 dogs at one point in February (when pollen …

Ethical Review Of Discipline-Based Education Research: Ensuring Fair Treatment For All, E. Elias Johnson

Undergraduate Honors Theses

As universities grapple with funding cuts and heightened social and political pressure, the emerging field of Discipline-Based Education Research (DBER) aims to improve student learning outcomes through experimental instruction. While using instruction as an experiment, with hypotheses and experimental tests, DBER research may affect student learning and experience in unintended ways for students involved in these classes. To address this concern, I impose ethical frameworks, namely contractualism, to better understand how the values of each stakeholder, students enrolled in experimental courses and researchers using these courses to test hypotheses, interact. I also identify potential misalignments. Following a contractual ethical framework, …

Early Peripheral Blood Gene Expression Predicts 90-Day Outcomes Following Subarachnoid Hemorrhage, Bodie Knepp, Garreck H Lenz, Frank R Sharp, Fernando Rodriguez, Huimahn Alex Choi, Aaron M Gusdon, Glen Jickling, Lara L Zimmermann, Ryan Martin, Jeffrey Vitt, Ben Waldau, Brandon J Cord, Alan Yee, Kwan Ng, Nerissa U Ko, Heather Hull, Bradley P Ander, Boryana Stamova

Faculty, Staff and Student Publications

BACKGROUND: Previous clinical, radiological and machine learning studies have predicted 90-day outcomes following subarachnoid hemorrhage (SAH). The present study was designed to determine whether early changes in mRNA expression of immune, clotting and other genes expressed in peripheral blood can predict patient outcomes at 90 days after SAH and possibly provide insights into the molecular factors that promote good versus poor outcomes.

METHODS: Peripheral blood was drawn after SAH and from vascular risk factor controls (VRFC) and RNAseq performed to measure mRNA expression. A mixed effects regression model identified potential predictors and machine learning algorithms derived the best predictors of …