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Matrix Metalloproteinase-9 (Mmp-9) Levels In Dentinal Fluid As A Diagnostic Biomarker For Irreversible Pulpitis, Aryo Megantoro, Valeria Widita Wairooy, Ratna Meidyawati, Endang Winiati Bachtiar

Journal of Dentistry Indonesia

Objective: Pulpitis is an inflammatory condition of the dental pulp. The inflammatory status can be accurately assessed by histological examination. Biomarkers, such as matrix metalloproteinases (MMPs), are effective indicators of inflammation severity. Among these, matrix metalloproteinase-9 (MMP-9) has emerged as a key mediator of inflammatory processes associated with pulpitis. However, its clinical application as a biomarker remains limited owing to challenges in its extraction. This study aimed to evaluate the effectiveness of MMP-9 extracted from the dentinal fluid as a biomarker for pulpitis. Methods: Dentinal fluid was collected using the blunt tip of a sterile paper point, following clean …

Individualized Oral Care Using Photobiomodulation And Tailored Brushing Method In A Patient With Maxillofacial Trauma – A Case Report, Shruthi Reghunath, Roshni Ramesh, S Santhosh Kumar, Anoop Sasi, Shahana C. Mohamed, Bilha Joy, Aswathy Jayasree

Journal of Dentistry Indonesia

Patients who report to the dental outpatient department following maxillofacial trauma often exhibit suboptimal oral hygiene, which is frequently attributed to challenges in sustaining oral care stemming from pain and restricted mouth opening after the injury. This case report aims to provide an individualized protocol of oral care and pain management for patients with maxillofacial trauma. Case report: A treatment protocol combining the Tailored Brushing Method (TBM), a personalized approach for at-home oral hygiene, and photobiomodulation using low-level laser was performed on a 24-year-old patient with maxillofacial trauma and poor oral hygiene. Results: The TBM is successful in achieving good …

How The Intake Of Pulses May Impact Metabolic Disorders And Dementia Risk: A Narrative Review, Lisa Michelle Belzer Salinas, Maricarmen Marroquin, Mariana Mendez, Isabel Omaña-Guzmán, Juan Carlos López-Alvarenga

Health & Biomedical Sciences Faculty Publications

We present a narrative review focusing on pulses’ geographical origin and distribution, their impact on human evolution and history, and their influence on human health. Pulses, including dry peas, beans, and lentils, are renowned for their richness in chemical antioxidants. Despite containing antinutrients, processing techniques preserve their health advantages. Epidemiological research has consistently demonstrated that the consumption of pulses is associated with favorable effects on metabolism. This evidence is further supported by molecular and clinical research, which has elucidated potential nutrigenomic mechanisms and effects on gut microbiota composition underlying their health benefits. However, the literature lacks randomized controlled clinical trials …

Antibacterial Analysis Of Human Amniotic Membrane Against Streptococcus Mutants, Streptococcus Sobrinus, And Enterococcus Faecalis, Mohamad Ezany Yusoff, Ruhil Hayati Hamdan, Haslina Taib, Tan Li Peng, Maizan Mohamed, Rumaizi Shaari, Mohamad Arif Awang Nawi

Journal of Dentistry Indonesia

Objectives: The human amniotic membrane (HAM) is a promising scaffold for oral applications due to its antimicrobial properties, which help protect against bacterial degradation. However, evidence of its activity against oral bacteria remains limited. Thus, this study aimed to evaluate the antibacterial activity of the HAM against selected Gram-positive oral bacteria, namely, Streptococcus mutans (S. mutans), Streptococcus sobrinus (S. sobrinus), and Enterococcus faecalis (E. faecalis). Methods: HAM in 1 cm²-pieces was inoculated with bacterial suspensions and incubated at 37 °C in 5% carbon dioxide (CO₂) for 48 hours to evaluate …

Shattering The Silence: The Path To Maternal Equity In Texas, Karah Renfroe

The Scholar: St. Mary's Law Review on Race and Social Justice

The Black maternal mortality crisis reflects the persistence of institutionalized racism embedded in the U.S. healthcare system. In Texas, Black women account for just 11% of births yet represent 31% of maternal deaths—a mortality rate more than twice that of their white counterparts. This staggering disparity has persisted, even as statewide initiatives have improved maternal outcomes for non-Black women. This Comment situates the current crisis within a broader historical continuum: from the coerced medical experimentation on enslaved Black women by figures such as J. Marion Sims, through the codified racism of the Jim Crow era, to present-day inequities ingrained in …

California Water Reuse: State Of The Industry As Direct Potable Reuse Comes Online, Guy Gutterman

Master's Projects and Capstones

Since the early 1900’s, California has found ways to reuse its wastewater, and in 2023 the state added a new method, Direct Potable Reuse (DPR), to its toolkit. DPR allows for advanced treated wastewater to be sent directly to a drinking water system, without an environmental buffer. Through a synthesis of the literature and related government documents of the state's water reuse history, an analysis of regional water recycling trends, and a survey of water utility professionals, this paper aims to understand DPR's future role in securing California's water supply. Historically, public perception has delayed adoption and development of California's …

Anexelekto (Axl)/Mer Inhibitor Tamnorzatinib In Patients With Relapsed/Refractory Acute Myeloid Leukaemia: Results From A Phase I (Monotherapy) And Phase Ii (Combination With Venetoclax) Clinical Study, Margaret T Kasner, Nigel Courtenay-Luck, Courtney Dinardo, Sean M Post, Praneeth Baratam, George N Magrath, Takaaki Nakamura, Akifumi Fujii, Sergio Prados, Naoki Honda, Mary Mcbride, Paula Edwards-Holmes, Robert Stuart

Faculty, Staff and Student Publications

Introduction: Relapsed/refractory (R/R) acute myeloid leukaemia (AML) is a life-threatening haematological malignancy without effective treatments. Anexelekto (Axl) and Mer receptor tyrosine kinases have emerged as important therapeutic targets in AML for their crucial role in survival of AML cells. Tamnorzatinib (ONO-7475) is a potent and highly selective inhibitor of Axl/Mer. We report first-in-human study of tamnorzatinib (NCT03176277) in patients with R/R AML.

Methods: Tamnorzatinib was administered as monotherapy (n = 20) to determine an appropriate biological dose of tamnorzatinib and then in combination (n = 22) with venetoclax to evaluate safety and clinical efficacy.

Results: Tamnorzatinib was safe …

Stromal Fibroblastic Mutant Trp53 Promotes Mammary Tumor Development Via Enhanced Secretion Of Paracrine Factors, Bin Liu, Shunbin Xiong, Abie Williams-Villalobo, Gilda Chau, Yuan Qi, Hehua Chen, Carenza Johnson, Dhruv Chachad, Joy Mcdaniel, Xiaoping Su, Adel K El-Naggar, Guillermina Lozano, Yun Zhang

Faculty, Staff and Student Publications

Mutations in the tumor suppressor gene TP53 have been identified in breast cancer-associated fibroblasts and are associated with poor patient prognosis. However, the functional impact of fibroblastic mutant p53 on breast cancer development remains unclear. To investigate this, we compared female mice harboring HER2-driven mammary tumors with a fibroblast-specific Trp53 mutation (NP) to those with wild-type fibroblastic Trp53 (N). NP mice exhibited significantly shorter median tumor-free survival than N mice. RNA sequencing of NP and N tumors and mammary glands revealed numerous differentially expressed genes (DEGs) between tumors and the corresponding glands in both genotypes. Notably, the NP tumors showed …

Measurable Imaging-Based Changes In Enhancement Of Intrahepatic Cholangiocarcinoma After Radiotherapy Reflect Physical Mechanisms Of Response, Brian De, Prashant Dogra, Mohamed Zaid, Dalia Elganainy, Kevin Sun, Ahmed M Amer, Charles Wang, Michael K Rooney, Enoch Chang, Hyunseon C Kang, Zhihui Wang, Priya Bhosale, Bruno C Odisio, Timothy E Newhook, Ching-Wei D Tzeng, Hop S Tran Cao, Yun S Chun, Jean-Nicholas Vauthey, Sunyoung S Lee, Ahmed Kaseb, Kanwal Raghav, Milind Javle, Bruce D Minsky, Sonal S Noticewala, Emma B Holliday, Grace L Smith, Albert C Koong, Prajnan Das, Vittorio Cristini, Ethan B Ludmir, Eugene J Koay

Faculty, Staff and Student Publications

Escalated doses of radiotherapy associate with improved local control and overall survival (OS) in intrahepatic cholangiocarcinoma (iCCA), but personalization remains limited because conventional size-based CT criteria correlate poorly with outcomes. We hypothesized that quantitative enhancement measurements would better predict clinical outcomes and guide individualized RT optimization. In a retrospective cohort of 154 patients, we analyzed pre- and post-RT CT scans using quantitative European Association for Study of Liver (qEASL) to derive viable tumor volumes, comparing enhancement-based metrics with size-based RECIST and linking them to outcomes via survival and mathematical modeling. Change in enhancement volume was strongly associated with OS after …

Understanding Acceptance Capacity And Intentions Of Mississippians To Participate In The Conservation And Management Of Black Bears In Mississippi, Basant Pant

Theses and Dissertations

This dissertation explores the acceptance capacity of Mississippians towards black bears (Ursus Americanus), and their intentions to participate in their conservation and management. It intends to bridge the theory and application of wildlife acceptance capacity among three main objectives. First, a systematic literature review of journal articles employing the Search, Appraisal, Synthesis and Analysis (SALSA) method revealed the development phase of Wildlife Acceptance Capacity (WAC)-conceptual phase (1988 -2000) and applied phase (post 2000), highlighting the strong scholarly collaboration among high human development index (HDI) countries with limited collaboration with the low HDI countries. Second, a mail survey of 4,080 Mississippi …

The Social In The Spiritual: Non-Theistic Spirituality In 12-Step Addiction Recovery, Steph Jacobs

Theses and Dissertations

To investigate whether Western-raised Narcotics Anonymous (NA) members engage in non-theistic spirituality and non-humanist modes of sociality with non-human beings, I conducted six qualitative interviews and a small-scale survey within a Vancouver NA community. The majority of participants practice non-theist spirituality, and three interviewees relate to non-humans in ways not accounted for by Western humanism. Findings suggest that connection and sociality are intrinsically woven into recovery and well-being. This research opens conversations about non-theistic spirituality in NA recovery, non-human sociality and healing, processes of ontological negotiation, and the entanglement of spirituality, sociality, and well-being. Through daily practices of exploration and …

Genetic Reconstruction And Diversity Analysis In The Usda Forest Service Populus Deltoides Breeding Collection, Carlos Armando Rivera Moreno

Theses and Dissertations

The thesis investigates the genetic structure and diversity of the Populus deltoides collection from the USDA Forest Service breeding program. Using genomics techniques, six population groups with varying levels of admixture were identified, revealing extensive historical recombination and complexity in the population structure, which contrasts with earlier studies from different regions. The research also confirms the collection's integrity by detecting operational errors and contamination, addressed through genetic identity and parentage analysis. Notably, over 80% of the clones have contributions from multiple ancestors, indicating widespread interbreeding. Additionally, a reliable database was created, covering about 96% of the unique genotypes. This enables …

Genomics Insights Into The Biogeography And Evolution Of Galapagos Iguanas Using Radseq And Wgseq Techniques, Cecilia Paradiso

Theses and Dissertations

The Galápagos archipelago is known for its unique endemic fauna shaped by isolation and geological dynamism. This thesis explores the evolutionary history of Galápagos iguanas, a monophyletic group comprising the marine iguana (Amblyrhynchus cristatus) and three land iguanas: Conolophus marthae, C. pallidus, and C. subcristatus. These species differ in distribu- tion, population size, and conservation status, with C. marthae classified as Critically Endan- gered due to its restricted range and small population. The main goal of this thesis is to fill knowledge gaps concerning the evolutionary trajectories, demographic histories, and genetic var- iability of Galápagos iguanas. The first chapter reconstructs …

A Mixed-Method Study Of African American Parents’ Involvement In Their Children’S Individualized Education Program Process, Dischedia Tamarisi Williams

Theses and Dissertations

The major purpose of the study was to examine the unique experiences of African American parents regarding their parental involvement in their child’s Individualized Education Program process. In addition, the study aimed to investigate the perceptions of teachers and administrators regarding the experiences of the African American parents as they worked with the parents and their children during the IEP process. Epstein’s (1987, 2008) Model of Parental Involvement was used as a theoretical framework to underpin the study emphasizing six dimensions of parental involvement. The six dimensions of parental involvement include the following: parenting, communicating, volunteering, learning at home, decision-making, …

Use Of Wetlands By Migratory Waterbirds In The Lower Mississippi Alluvial Valley, Duncan Fraser

Theses and Dissertations

The Lower Mississippi Alluvial Valley (LMAV) is a critical stopover and wintering area for dozens of migratory waterbird species. For many species, especially shorebirds, shallow water and mudflats during migration and winter are vital for foraging and survival. Wetland restoration combined with strategic flooding practices can provide important resources for various waterbird guilds using the LMAV. I surveyed waterbirds during three migration seasons (January-May 2024 and 2025, and July-December 2024) across 62 total wetland units on four national wildlife refuges, four wildlife management areas, and one aquaculture facility in the Mississippi LMAV. I also compared abundance and richness of waterbirds …

Study Of Insect Frass-Associated Microbiome On Plant Growth And Their Potential Use As Biofertilizer, Jasmine Sahota

Theses and Dissertations

An increasing global food demand and the urgent need for sustainable agricultural practices have driven interest in insects as alternative feed and food sources. Insect frass, a by-product of insect rearing, represents a rich organic carbon source with diverse microbes that can enhance soil health and promote beneficial plant-microbe interactions. This study characterized the bacterial (16S-V4) and fungal (ITS2) microbiomes of frass from Black Soldier Fly (BSF) and Cricket species and evaluated their effects on maize (Zea mays) growth. Four frass variants were applied at rates of 56-280 kg ha⁻¹ in a pot experiment with untreated soil and mineral fertilizer …

Revision And Biogeography Of The Tribulus Group (Orthoptera, Acrididae, Melanoplinae, Melanoplus) And Establishment Of The Rusticus Group With A Description Of Four New Species Of West Of Mississippi River, Usa, Jireh Mwamukonda

Theses and Dissertations

The genus Melanoplus represents one of the most diverse groups of acridid grasshoppers in North America, comprising over 430 described species within the subfamily Melanoplinae. Among its various species groups, the Tribulus group consists of flightless grasshoppers typically found in open woodlands and forest margins, primarily in the eastern United States. The Melanoplus tribulus group was first established by Blatchley (1920) as Obovatipennis Group. However, since species groups are informal taxonomic units not governed by nomenclatural rules, the group later became known as the Tribulus group. It currently includes 11 taxa. These brachypterous species occur from New Jersey south Florida …

Inductively Heated Platinum Electrodes, Jayamini Madumali Mudugamuwa Hewage

Theses and Dissertations

This dissertation presents the fabrication and application of a 150 micrometer platinum microelectrode for induction heating, with a copper coil generating the electromagnetic field and the heating process controlled using pulse width modulation technique (PWM) to regulate the duty cycle of a high-frequency signal. Electrochemical characterization, including resonance frequency determination, peak-to-peak potential optimization, and scan rate variation, is conducted using a 5 mM [Ru(NH3)6]2+/3+ solution in 0.1 M KNO3 to calibrate current variations with changing duty cycles, while the temperature increase (delta T) is estimated using the Seebeck coefficient of [Ru(NH3)6]2+/3+. The study further explores the application of induction heating …

The Soil Greenhouse Gas Flux And Climate Mitigation Potential Of Conservation Reserve Program With Tree Planting In The Southeastern U. S., Jianing Liang

Theses and Dissertations

Afforestation is increasingly promoted as a nature-based solution to climate change, although its net impact on soil greenhouse gas (GHG) emissions remains variable across forest types, prior land uses, and environmental conditions. This dissertation investigates the soil GHG flux (CO2, CH4, N2O) responses and dynamics of afforestation under the Conservation Reserve Program (CRP) in the southeastern United States, with a specific focus on broadleaf and conifer tree planting practices. Drawing from a combination of meta-analysis, machine learning, and field-based observations across 73 sites, this research provides an integrated assessment of afforestation’s climate mitigation potential. In Chapter II, a meta-analysis of …

Electrospun Nanofiber Creation With Varying Polymer-Solvent Combinations For Air Filtration, Lancaster Jace Hill

Theses and Dissertations

This study aims to analyze various polymer-solvent combinations for electrospun creation of nanofiber media and to determine the best-suited solution for lab-grade electrospinning. Suitable solutions allow for controlled morphology of fiber diameters and for efficiency of media creation. The principal variables are solvent, concentration, and voltage. Humidity and temperature play a secondary variable role. The solution must withstand an electric field of ≤30 kV and be insoluble in water to maintain desired morphology and structure. Manipulation of the solutions and variables allow for fiber diameter optimization and beading minimization. High temperature filter applications require efficiency in intense heat and preservation …

Considerations For Cottonseed Oil As A Feedstock For Renewable Fuels, John Elmore

Theses and Dissertations

As the world population grows and the standard of living improves in developing countries, global energy demand will continue to rise, with energy use in the developing world expected to increase dramatically more than the per capita reductions in developed countries from efficiency improvements. Nearly a third of the total global energy demand is used for transportation, resulting in a substantial contribution to greenhouse gas (GHG) emissions. While the demand for energy rises, initiatives and regulations are underway to mitigate the amount of GHG emissions to Earth’s atmosphere. As efforts progress in industry, governments, and society to reduce the total …

Rapid Kinetic Fluorogenic Quantification Of Malondialdehyde In Ground Beef, Keshav Raj Bhandari

Theses and Dissertations

Presented herein is rapid kinetic fluorogenic method to quantify malondialdehyde (MDA) in ground beef, utilizing 2-thiobarbituric acid (TBA) as the fluorogenic probe. This assay significantly shortens the total analysis time, from sample preparation to data acquisition, to just six minutes presenting a major advancement over traditional methods that typically require two hours and multiple instruments. The assay’s robustness against matrix interferences was validated using sample volume variation and standard addition calibration methods. Additionally, the effects of ambient exposure to air, washing, and cooking on MDA content in raw ground beef were quantified. While both ambient exposure to air and cooking …

The Biology Of Green Antelopehorn Milkweed (Asclepias Viridis Walter) And Hemp Dogbane (Apocynum Cannabinum L.) And Response To Triclopyr Formulations And Other Auxin Herbicides, Kayla L. Broster

Theses and Dissertations

Studies were conducted in Oktibbeha and Clay Counties in Mississippi to determine the response of green antelopehorn milkweed and hemp dogbane to triclopyr and other auxin herbicides in non-cropland areas. These studies were conducted at four locations with well established populations for each species throughout 2020 to 2023, with applications repeated at each location the following year if populations persisted. Treatments included a high and low rate of each herbicide studied, with all four triclopyr formulations included for both species. Injury response data were collected two and four weeks after treatment and population density data were evaluated using individual stem …

Trace Mineral Supplementation Strategies For Beef Cattle During Preconditioning And Feedlot Receiving, Madeline G. Mcknight

Theses and Dissertations

Beef cattle routinely undergo a variety of stressors within the preconditioning and feedlot receiving phases which may impair animal performance and health. Trace mineral supplementation, either through dietary or injectable sources, is proposed to mitigate these effects through metabolic and immune system support. Two systematic reviews and meta-analyses were conducted to evaluate the efficacy of two different oral supplementation methods, organic (OTM) and inorganic (INR), and injectable trace mineral (ITM) solutions on average daily gain (ADG) and morbidity. Across 20 studies, OTM supplementation increased ADG (P = 0.01) when compared to INR, but did not affect morbidity (P = 0.92). …

Spatiotemporal Ecology Of Mycobacterium Ulcerans And Mycolactone Functions In French Guiana And Southeastern United States Aquatic Environments, Magdalene Dogbe

Theses and Dissertations

Mycobacterium ulcerans, the causative agent of Buruli ulcer, produces mycolactone, a polyketide toxin traditionally studied for its role in human pathogenesis. This dissertation presents a comprehensive spatiotemporal analysis of M. ulcerans and mycolactone producing mycobacteria (MPM) ecology in the Americas and also reveals mycolactone's role in the environment as a microbial community regulator. Through comparative studies in French Guiana (endemic) and the southeastern United States (non-endemic), combined with experimental microcosm investigations, this research contributes to environmental pathogen ecology understanding. Environmental surveillance across 2,226 samples from French Guiana revealed complete MPM restriction to freshwater environments, with zero detections from 1,226 coastal …

Design, Development, And Validation Of An Automated Hole-Punching System For Precision Irrigation In Lay-Flat Poly Pipe Tubing, Micah James Foster

Theses and Dissertations

Increasing pressure on water resources in agricultural regions, particularly the Mississippi Delta, demands innovative irrigation technologies to optimize water usage while maintaining crop productivity. This research presents the design, development, and validation of an automated hole-punching system for lay-flat poly pipe tubing used in precision irrigation applications. The system ensures accurate and consistent hole placement through an integrated rotary cutting die, a PLC-based control architecture, stepper motor actuation, and distance-sensing and position-synchronization. The software logic maintains precise hole spacing despite variations in tubing speed. System performance was evaluated through extensive testing and statistical analysis of hole-spacing accuracy, repeatability, and sagitta-based …

Small Area Estimation Methods For County-Level Forest Biomass Estimation, Pratyush Dhungana

Theses and Dissertations

We evaluated small area estimation (SAE) methods for county-level forest biomass across four Forest Inventory and Analysis (FIA) regions in the contiguous United States using the coefficient of variation and relative root mean squared error. The Standard Fay–Herriot (FH) model was compared with multivariate, spatial, and measurement-error extensions, while the unit-level Battese–Harter–Fuller (BHF) model was compared with mixed-effects random forests (MERF) with auxiliary data from remote sensing. Spatial FH improved precision when spatial dependence was strong; otherwise, Standard FH was more reliable. All FH models were effective with fewer than 100 plots. Measurement-Error FH produced more accurate estimates than FIA …

Lecun-Pso Hybrid Initialization Of Neural Network Using Asymmetric Gait Features For Classification Of Parkinson’S Disease, Michael Joseph Carter

Theses and Dissertations

Parkinson's disease (PD) is a complex condition with a wide range of clinical symptoms. It is a progressive neurological disorder that has afflicted an estimated 1 million people in the US and 10 million worldwide. The diagnosis of PD is typically based on the presence of clinical features, with no specific diagnostic test or biomarker. The methods of assessment for PD are also used, in whole or in part, for similar symptom diseases such as Multiple Sclerosis, Essential Tremors, Multiple System Atrophy, Supranuclear Palsy, Dementia with Lewy bodies and Huntington’s disease. Many of the current clinical tests have low sensitivity …

Leveraging Google Earth Engine For Computationally Efficient Pixel-Level Analysis And Vector Delineation From Satellite Data., Rishita Garg

Theses and Dissertations

Analyzing large-scale, high-resolution satellite imagery is a computationally intensive task requiring time and computing resources. This can be accelerated using cloud computing platforms such as Google Earth Engine (GEE) where computational and storage requirements can be scaled based on demand. However, cloud-based platforms for processing high-resolution imagery remain underutilized in environmental applications such as agriculture, and forest health. This thesis explored the application of GEE to two geospatial problems in agricultural conservation and disease mapping in forestry: 1) Extraction of agricultural field boundaries from Sentinel-2 satellite imagery, for use in conservation, precision agriculture, land management, and organization, etc., and 2) …

In The Mouth Or In The Gut? Innovation Through Implementing Oral And Gastrointestinal Health Science In Chronic Pain Management, Jo Nijs, Burel R Goodin, Et Al.

2020-Current year OA Pubs

Recent scientific advances point towards an important role for oral and gastrointestinal health in people with chronic pain. Poor oral health (e.g., periodontitis, tooth loss) is observed in subgroups of the chronic pain population, including abdominal pain, low back pain, fibromyalgia, and rheumatoid arthritis. In addition to poor oral health, studies have also revealed altered intestinal microbiota compositions in various types of chronic pain, including people with chronic low back pain, knee osteoarthritis, visceral pain, fibromyalgia, tinnitus, and migraine. While overweight/obesity contributes to the likelihood of gut dysbiosis, normal-weight individuals with chronic pain also more often present with poor gut …