Digital Commons Network^™

2021g_Sm25_Approved_Nc_Bio_5383-Vertebrate-Endocrinology, Graduate Council

All Approved Curriculum

No abstract provided.

2021g_Sm21_Approved_Cd_Bio_5611-Radiation-In-Our-World, Graduate Council

All Approved Curriculum

No abstract provided.

2021g_Sm22_Approved_Cm_Bio_5454-Herpetology, Graduate Council

All Approved Curriculum

No abstract provided.

2021g_Sm20_Approved_Cd_Bio_5403-Comparative-Vertebrate-Reproduction, Graduate Council

All Approved Curriculum

No abstract provided.

2021g_Sm18_Approved_Cd_Bio_5361-Lab-For-Mammalian-Neurobiology, Graduate Council

All Approved Curriculum

No abstract provided.

2021g_Sm19_Approved_Cd_Bio_5363-Mammalian-Neurobiology, Graduate Council

All Approved Curriculum

No abstract provided.

2021g_Sm16_Approved_Cd_Bio_5001-Lab-Techniques-In-Electron-Microscopy, Graduate Council

All Approved Curriculum

No abstract provided.

2021g_Sm15_Approved_Nc_Bio_5604-Conservation-Genomics, Graduate Council

All Approved Curriculum

No abstract provided.

2021g_Sm17_Approved_Cd_Bio_5003-Lab-For-Lab-Techniques-In-Electron-Microscopy, Graduate Council

All Approved Curriculum

No abstract provided.

2021g_Sm10_Approved_Cd_Bio_5403-Comparative-Vertebrate-Reproduction, Graduate Council

All Approved Curriculum

No abstract provided.

2021g_Sm11_Approved_Cd_Bio_5611-Radiation-In-Our-World, Graduate Council

All Approved Curriculum

No abstract provided.

2021g_Sm09_Approved_Cd_Bio_5363-Mammalian-Neurobiology, Graduate Council

All Approved Curriculum

No abstract provided.

2021g_Sm08_Approved_Cd_Bio_5361-Laboratory-For-Mammalian-Neurobiology, Graduate Council

All Approved Curriculum

No abstract provided.

2021g_Sm06_Approved_Cd_Bio_5001-Laboratory-Techniques-In-Electron-Microscopy, Graduate Council

All Approved Curriculum

No abstract provided.

2021g_Sm07_Approved_Cd_Bio_5003-Laboratory-For-Laboratory-Techniques-In-Electron-Microscopy, Graduate Council

All Approved Curriculum

No abstract provided.

2021g_Lac28_Approved_Name_Change_Ma-Criminology-And-Criminal-Justice, Graduate Council

All Approved Curriculum

No abstract provided.

2022g_Ebs52_Approved_Cm_Psy_7633-Physiological-Psychology-And-Psychopharmacology, Graduate Council

All Approved Curriculum

No abstract provided.

The Life And Legacy Of Count Leon: The Man Who Cleft The Harmonie, Eileen Aiken English

Communal Societies

No abstract provided.

Trans Lives: Human Dignity And Executive Power, Jack Mcroberts

Bates College Undergraduate Law Review

No abstract provided.

Conflating Disease, Morality, And Sex: Regulating Military Fitness In The War Years, Hanna Ranis

Bates College Journal of Political Studies

The United States military worried about the impact of venereal diseases on the ability of soldiers to fight in both World War 1 and 2. The war years thus resulted in an increase in regulations that sought to curb the spread of venereal diseases. Much of this regulatory shift has focused on how police targeted women who were suspected of spreading venereal diseases to American soldiers. Women were profiled as promiscuous and possible sex workers, with the lines between the two categories becoming increasingly blurred. Policing was viewed as a public health regulatory mechanism that needed to be carried out …

Bates College Journal Of Political Studies: Volume Ii, Issue 1, Fall 2025, Bates Initiative For Government Studies

Bates College Journal of Political Studies

No abstract provided.

Combination Treatment Of Cordycepin And Radiation Induces Apoptosis Accompanied By Protective Autophagy In Tm3 Mouse Leydig Progenitor Cells, Yu-Yan Lan, Yi-Ping Lee, Wei-Ru Huang, Chun-Ying Yu, Lyh-Jyh Hao, Chun-Hung Lin, Bu-Miin Huang

Journal of Food and Drug Analysis

Leydig cells are anatomically located in the testicular interstitial tissue, and their main function is to produce and secrete testosterone and indirectly support spermatogenesis. We previously reported that the combination treatment of cordycepin and radiation can effectively induce Leydig tumor cell apoptosis through cell cycle arrest, caspase activation, endoplasmic reticulum (ER) stress, reactive oxygen species (ROS) accumulation, and DNA damage. However, there is still a lack of scientific evidence for the susceptibility of normal Leydig cells to the combination treatment. In the present study, mouse TM3 Leydig progenitor cells were used as a model to evaluate the effects and mechanisms …

Development Of An Untargeted Metabolomics Analytical Protocol For Fecal Samples By Liquid Chromatography–Mass Spectrometry, Tsai-Wei Ting, Chih-Ning Cheng, Chieh-Chang Chen, Ching-Hua Kuo

Journal of Food and Drug Analysis

Gut microbiota has recently gained attention for its role in regulating multiple host pathways and contributing to disease developments. Fecal metabolomics using liquid chromatography—mass spectrometry (LC—MS) offers a promising approach to study gut microbial metabolites; however, it remains technically challenging due to the complex, heterogeneous nature of fecal samples and the lack of standardized protocols. This study aimed to establish a robust and reproducible untargeted fecal metabolomics workflow. We systematically evaluated sample preparation parameters―including sample amount, extraction solvent, numbers of extraction, and sample-to-solvent ratio―and assessed method reproducibility. Additionally, we compared three LC—MS data acquisition workflows using 10 samples from inflammatory …

Dna Tetrahedron-Au Nps-Go For Enhanced Fluorescence Detection Of Serotonin, Zhang Yun, Wu Qiong, Gao Hui, Zhang Hua, Miao Xiang-Min

Journal of Food and Drug Analysis

Evidence had accumulated that serotonin (5-HT), a hormone and neurotransmitter, was not only involved in a variety of different physiological and central nervous system functions but also in the development and manifestation of psychiatric diseases. Here, DNA tetrahedron-Au NPs-GO for enhanced fluorescence sensor was designed for detecting serotonin. Au NPs-GO was used as a fluorescence quencher, while fluorophore-labeled DNA tetrahedron was used as a donor, resulting in fluorescence resonance energy transfer (FRET) from the fluorophore to Au NPs-GO (signal off). With the strong binding ability of aptamer to serotonin, S5 was released from Aptamer: S5 duplex, then reacted with the …

Carotenoids Identified From Slipper-Shaped Oyster Magallana Bilineata Powder Residue Exhibit Potent Biological Activities, Rhoda Mae C. Simora, Raymund B. Parcon, Andrea Roxanne J. Anas, Tatsufumi Okino

Journal of Food and Drug Analysis

Carotenoids are a diverse class of biologically active compounds that contribute significantly to human health, serving vital functions in nutrition and overall well-being. Magallana bilineata, a commercially important oyster species, yields a shelf-stable powder residue possessing bioactivities with unknown specific compounds. Carotenoids are key marine bioactive compounds, but their presence in oysters remains underexplored. The present study aimed to identify the bioactive compounds from oyster powder residue through mass spectrometry for optimum utilization and value creation as a biomedical resource. The study employed solvent extraction of oyster powder residue, followed by fractionation using octadecylsilyl (ODS) column chromatography, liquid chromatography-mass …

Selective Sodium-Glucose Cotransporter Two Inhibitor Empagliflozin Ameliorates Diabetic Cardiomyopathy By Activating The Ampk/Tfeb Signaling Pathway., Man-Chen Hsu, Ru-Wen Chang, Mu-Chun Wang, Chia-Hui Chen, Wen-Hua Chen, Tzong-Shyuan Lee, Chih-Hsien Wang

Journal of Food and Drug Analysis

The highly selective SGLT2 inhibitor (SGLT2i) is reported to have beneficial effects on diabetic cardiac hypertrophy; however, the molecular mechanisms underlying the cardioprotection of SGLT2i are not fully understood. In this study, we investigated the impact of the SGLT2 Inhibitor empagliflozin (EMPA) on diabetic hearts and its regulatory mechanisms in high-fat-diet (HFD)- and streptozotocin (STZ)-treated rats. Male rats orally administered HFD/STZ treatment for eight weeks, with or without EMPA (10 mg/kg), were used as our in vivo model. Hematoxylin and eosin (H&E) staining was used for histological examination. Western blot analysis and immunohistochemistry were used to analyze the expression of …

Targeting Chemical Carcinogenesis: Α-Pinene And D-Limonene As Chemopreventive Agents Against Nnk/ Tcdd- And Urethane-Induced Lung Tumorigenesis, Kuo-Ching Huang, Vui-Hyen Chew, Yu-Ying Chen, Huey-Jen Su, Hao-Ting Chang, Rong‑Jane Chen, Ying‑Jan Wang

Journal of Food and Drug Analysis

Lung cancer is the leading cause of cancer-related deaths worldwide, driven by carcinogens such as tobacco-derived nitrosamines, dioxins, and urethane. This study evaluated the chemopreventive effects of two monoterpenes, α-pinene and D-limonene, using NNK/TCDD- and urethane-induced lung tumor models and A549 lung cancer cells. Both compounds significantly reduce tumor number and size, with enhanced effects when combined. Mechanistic studies revealed suppression of PRC1, β-catenin, and c-Myc, alongside activation of p53, Bax, and caspase-3, indicating inhibition of the PRC1—Wnt/β-catenin pathway and induction of apoptosis. These findings suggest α-pinene and D-limonene as safe, promising agents for lung cancer chemoprevention.

Fish Oil Rich In Ω-3 Fatty Acid Alleviates Long-Term High Fructose Consumption-Induced Fatty Liver And Kidney Dysfunction In Rats, Shing-Hwa Liu, Ruoh-Wenn Hung, Ting-Yu Chang, Meng-Tsan Chiang

Journal of Food and Drug Analysis

Excessive fructose intake leads to fatty liver and kidney dysfunction, with associated inflammation and metabolic disturbances. This study evaluated the effects of fish oil rich in ω-3 fatty acid on these conditions in rats fed a high- fructose diet. Male Sprague Dawley rats were divided into three groups: normal diet, high-fructose (HF) diet, and high- fructose diet with 5% fish oil supplementation. The experiment lasted for 21 weeks. Fish oil supplementation significantly reduced blood levels of total cholesterol, triglycerides, and advanced glycation end products (AGEs) in HF-fed rat. It also improved liver function markers and kidney function indicators. Mechanistically, fish …

Cordycepin In Cancer Therapy: A Bibliometric Analysis And Review Of Mechanisms, Zhiwei Ouyang, Yufei Zhang, Jianghan Ning, Yayi Tu, Bin He

Journal of Food and Drug Analysis

Cordycepin (3’-deoxyadenosine), a major bioactive component derived from fungi of the genus Cordyceps, has garnered significant attention in recent years for its potent antitumor properties. Drawing on literature indexed in the Web of Science Core Collection from 2004 to 2025, this study employs bibliometric tools―specifically CiteSpace and VOSviewer―to systematically examine developmental trends, research hotspots, and emerging frontiers in the field of cordycepin-related cancer research. The analysis maps a shift in focus from early-stage pharmacological validation to more advanced investigations into molecular mechanisms, with particular emphasis on cell cycle regulation. Keyword burst analysis highlights bursts in terms such as “apoptosis,” “cell …

Research And The Information Landscape, Libby Wheeles, Helena Marvin

Open Educational Resources Collection

This open textbook accompanies the University of Missouri-St. Louis class INTDSC 1010: Research and the Information Landscape. Intended for undergraduates new to academic research, the course covers practical search and evaluation skills as well as a basic introduction to the world of scholarly communication. In Fall 2025, the course’s learning objectives were:

1. Evaluate whether a source is appropriate for college-level research.
2. Navigate library search tools to find relevant results and improve research efficiency.
3. Analyze the goals and limitations of non-library tools in the research landscape.
4. Explain the basic history and current broad practices of scholarly communication.
5. Contribute to a small-scale …