Open Access. Powered by Scholars. Published by Universities.®

Digital Commons Network

Open Access. Powered by Scholars. Published by Universities.®

Discipline
Institution
Keyword
Publication Year
Publication
Publication Type
File Type

Articles 18811 - 18840 of 817980

Full-Text Articles in Entire DC Network

Under What Circumstances Is “Caste” Likely To Be Useful As An Analytic Concept (And Should We Care)?, Sanford Levinson, Robert L. Tsai Dec 2025

Under What Circumstances Is “Caste” Likely To Be Useful As An Analytic Concept (And Should We Care)?, Sanford Levinson, Robert L. Tsai

Maryland Law Review

No abstract provided.


Adjudicated Cardiovascular Events In Patients With Covid-19: Association With Vaccination Status And Changes Over Time, Behnood Bikdeli, Darsiya Krishnathasan, Antoine Bejjani, Candrika D. Khairani, Nada Hamade, Umberto Campia, Julia Davies, Nicole Porio, Ali Assi, Andre Armero, Anthony Tristani, Marcos D. Ortiz-Rios, Victor Nauffal, Zaid I. Almarzooq, Eric Q. Wei, Bridget Mcgonagle, Mariana Pfeferman, Sina Rashedi, Alyssa Sato, Giovanni Scimeca, Valeria Zuluaga-Sánchez, Mehrdad Zarghami, Aditya Achanta, Sirus Jesudasen, Bruce C. Tiu, Geno J. Merli, Orly Leiva, John Fanikos, Aditya M. Sharma, Samantha M. Rizzo, Ruth B. Morrison, Alec Vishnevsky, Shiavax J. Rao, Sivan Naveh, Abdelghani El Rafei, James Welker, Marc P. Bonaca, Brett J. Carroll, Samuel Z. Goldhaber, Zhou Lan, Gregory Piazza, The Corona-Vte Network Investigators Dec 2025

Adjudicated Cardiovascular Events In Patients With Covid-19: Association With Vaccination Status And Changes Over Time, Behnood Bikdeli, Darsiya Krishnathasan, Antoine Bejjani, Candrika D. Khairani, Nada Hamade, Umberto Campia, Julia Davies, Nicole Porio, Ali Assi, Andre Armero, Anthony Tristani, Marcos D. Ortiz-Rios, Victor Nauffal, Zaid I. Almarzooq, Eric Q. Wei, Bridget Mcgonagle, Mariana Pfeferman, Sina Rashedi, Alyssa Sato, Giovanni Scimeca, Valeria Zuluaga-Sánchez, Mehrdad Zarghami, Aditya Achanta, Sirus Jesudasen, Bruce C. Tiu, Geno J. Merli, Orly Leiva, John Fanikos, Aditya M. Sharma, Samantha M. Rizzo, Ruth B. Morrison, Alec Vishnevsky, Shiavax J. Rao, Sivan Naveh, Abdelghani El Rafei, James Welker, Marc P. Bonaca, Brett J. Carroll, Samuel Z. Goldhaber, Zhou Lan, Gregory Piazza, The Corona-Vte Network Investigators

Jefferson Hospital Staff Papers and Presentations

BACKGROUND: Patients with COVID-19 are at risk of thrombotic and cardiovascular complications. Existing risk estimates derive from early COVID-19 experiences. More recent event rates, temporal trends, and the association between vaccination status and cardiovascular outcomes remain unclear.

METHODS: The CORONA-VTE Network (COVID-19 Registry to Assess Frequency, Risk Factors, Management, and Outcomes of Arterial and Venous Thromboembolic Complications) multicenter registry included patients with COVID-19 from March 2020 to February 2024. A composite of venous and arterial thrombotic events and a composite of adjudicated cardiovascular events were assessed at 90 days after COVID-19 diagnosis. Time-to-first-event analyses were stratified by inpatients and outpatients …


Strategic Planning Book 2019-2025, Dmacc Dec 2025

Strategic Planning Book 2019-2025, Dmacc

Strategic Planning

"A small team worked diligently throughout the summer and fall to complete the Strategic Plan Book, a lookback at DMACC’s goals, initiatives, and progress over the past several years. This comprehensive booklet highlights key success metrics like reduced DFW rates and improved credit hour completion and includes narratives about achievements in quality and excellence across the district." ~ Office of Institutional Effectiveness 12/15/2025


Enhancing Fuel Performance Of Molten Salt Reactors Through Improved Thermophysical Property Data, High-Fidelity Simulation, And Advanced Control Strategies, Jackson Seth Ivory Dec 2025

Enhancing Fuel Performance Of Molten Salt Reactors Through Improved Thermophysical Property Data, High-Fidelity Simulation, And Advanced Control Strategies, Jackson Seth Ivory

Theses and Dissertations

The deployment of molten salt reactors (MSRs) as next-generation nuclear technology requires accurate thermophysical property data, validated system models, and advanced control strategies to ensure safe and economically competitive operation. This dissertation, Enhancing Fuel Performance of Molten Salt Reactors Through Improved Thermophysical Property Data, High-Fidelity Simulation, and Advanced Control Strategies, integrates experimental measurements, thermal hydraulic simulation, and model predictive control (MPC) to enhance understanding of MSR fuel behavior under steady state and transient conditions. New density and heat capacity measurements of UF4-FLiNaK molten salts were obtained using Archimedean and differential scanning calorimetry methods, respectively, to address critical gaps for fueled …


Social Murder And The Antisocial Contract, Marissa Jackson Sow Dec 2025

Social Murder And The Antisocial Contract, Marissa Jackson Sow

Maryland Law Review

No abstract provided.


Green Synthesis Of And Antimicrobial Susceptibility Testing Of (2z)-2-[(4-Fluorophenyl)Methylidene]-1-Benzofuran-3-One, Rod Albert C. Olofernes Dec 2025

Green Synthesis Of And Antimicrobial Susceptibility Testing Of (2z)-2-[(4-Fluorophenyl)Methylidene]-1-Benzofuran-3-One, Rod Albert C. Olofernes

Honors Theses

Antimicrobial resistance is a global health challenge, rendering once-effective antibiotics less potent or entirely ineffective. In response, there is increasing interest in developing antimicrobial agents through environmentally sustainable methods. In this study, a fluorinated aurone derivative, (2Z)-2-[(4-fluorophenyl)methylidene]-1-benzofuran-3-one, was synthesized using a green Knoevenagel condensation approach. Eco-friendly catalysts were employed to minimize environmental impact and avoid hazardous byproducts. Product formation was confirmed to avoid wasting resources. The compound was evaluated for antimicrobial properties using a Kirby-Bauer plate, but did not demonstrate consistent or significant antimicrobial activity, therefore lacking promise as a standalone antibiotic.


2025 December 16 - Medical Student Education Committee Minutes, Medical Student Education Committee, East Tennessee State University Dec 2025

2025 December 16 - Medical Student Education Committee Minutes, Medical Student Education Committee, East Tennessee State University

Medical Student Education Committee Minutes

No abstract provided.


Investing In Youths And Their Families: A Proposal For Grant Funding To Expand Mental Health Services At A Community-Based Center, Eliana M. Lopez Dec 2025

Investing In Youths And Their Families: A Proposal For Grant Funding To Expand Mental Health Services At A Community-Based Center, Eliana M. Lopez

ETD Collection

Mental health services across the United States remain inequitably distributed, leaving under-resourced communities with limited access to essential services (Breslau et al., 2022). These disparities persist even in large metropolitan areas like New York City (NYC), with the Bronx, one of the city’s most historically marginalized and under-resourced borough, being especially vulnerable to disparities in mental health care (Breslau et al., 2022). The Family Advocacy Program (FAP), a community-based center part of the Department of Pediatrics at Jacobi Medical Center (JMC), is presently in need of additional financial resources to further expand their services to meet the rising mental health …


Molecular Effects Of Glucose On Mir503hg-Regulated Genes In Triple-Negative Breast Cancer, Victoria Reid, Barbara Yang, Kyle Russo, Melina J. Sedano, Ramesh Choudhari, Enrique I. Ramos, Shrikanth S. Gadad Dec 2025

Molecular Effects Of Glucose On Mir503hg-Regulated Genes In Triple-Negative Breast Cancer, Victoria Reid, Barbara Yang, Kyle Russo, Melina J. Sedano, Ramesh Choudhari, Enrique I. Ramos, Shrikanth S. Gadad

School of Medicine Publications

Triple-negative breast cancer (TNBC) is the most aggressive breast cancer subtype, characterized by a lack of key hormone receptors in tumor cells. As there are limited treatment options for these patients, it is crucial to understand the underlying mechanisms by which TNBC constantly evolves and evades treatments. In this regard, the pervasive nature of transcription provides a potential reservoir of transcripts, including both coding and noncoding, that TNBC leverages to sustain a proliferative advantage and support tumor growth. TNBC is affected by energy sources such as glucose, which can have a profound impact on gene expression regulation mediated by various …


Effectiveness Of Dna Recovery Success From Porcine Metacarpals And Phalanges Submerged In Household Chemicals, Jessica Di Re Dec 2025

Effectiveness Of Dna Recovery Success From Porcine Metacarpals And Phalanges Submerged In Household Chemicals, Jessica Di Re

Honors Theses

This experiment evaluated the DNA recovery success from phalanges and metacarpals isolated from fleshed porcine feet that were soaked in different household cleaners and chemicals. Three sets of two porcine feet were submerged in Drano, method: All-Purpose Cleaner, and a 1:1 dilution of lemon juice to tap water, respectively. Another set of two porcine feet, assigned to the control group, was left unsubmerged. All four sets were left to decompose for 28 days. Pictures and weights were taken once a week for the duration, before the bones were isolated and powdered for extraction using the BTA Prepfiler Kit, followed by …


Synteny To Snps: Comparative And Population Genomics Of Endemic Gila River Fishes, Alexander C. Cameron Dec 2025

Synteny To Snps: Comparative And Population Genomics Of Endemic Gila River Fishes, Alexander C. Cameron

Biology ETDs

Population genomic data are becoming an essential component of the best available science used by conservation professionals to make management decisions to preserve biodiversity in a rapidly changing world. The proliferation of high-throughput sequencing technologies has made generating genome scale data feasible for non-model organisms that are of conservation concern. In addition to applicability in conservation science, genomic data enable the exploration of basic questions related to species evolution. To that end, this body of research exemplifies the applied and basic utility of genomic data and is focused on two federally-protected minnows endemic to the Gila River basin, Loach Minnow …


Cv: Jodi Faulk (Radiography), Jodi Faulk Dec 2025

Cv: Jodi Faulk (Radiography), Jodi Faulk

Health Sciences Department Curricula Vitae

No abstract provided.


Comparison Of Cost, Accessibility, Speed, And Efficiency Of Modern Microbial Detection Methods For Wastewater Surveillance And Their Potential Benefits In Low-Resource Settings, Gloria Rodriguez, Davida Smyth Dec 2025

Comparison Of Cost, Accessibility, Speed, And Efficiency Of Modern Microbial Detection Methods For Wastewater Surveillance And Their Potential Benefits In Low-Resource Settings, Gloria Rodriguez, Davida Smyth

Masters Theses (Archived)

During the COVID-19 pandemic, wastewater surveillance helped predict the emergence of several waves of the SARS-CoV-2 virus, sometimes before clinical detection, alerting public health authorities to investigate. As human fecal material can contain the nucleic acids of both DNA- and RNA-based pathogens, new methods isolating total nucleic acid (TNA) can be used to detect a wider variety of pathogens and genetic targets. Wastewater Surveillance is faster, cost effective and scalable. This study compared three commercially available TNA extraction kits: Promega Rapid Capture Beads (Rapid), Maxwell RSC Enviro Total Nucleic Acid (Vacuum), and Nanotrap® Microbiome A and B Enviro Water Protocol …


Mitigating Risk Of Premature Ovarian Insufficiency Using Adjunct Chinese Herbal Medicines: A Nested Patient-Control Study In Female Cancer Patients With Chemotherapy, Tzu-Ning Tseng, Hou-Hsun Liao, Hanoch Livneh, Ming-Chi Lu, Szu-Chin Li, Tzung-Yi Tsai Dec 2025

Mitigating Risk Of Premature Ovarian Insufficiency Using Adjunct Chinese Herbal Medicines: A Nested Patient-Control Study In Female Cancer Patients With Chemotherapy, Tzu-Ning Tseng, Hou-Hsun Liao, Hanoch Livneh, Ming-Chi Lu, Szu-Chin Li, Tzung-Yi Tsai

Leadership, Learning and Counseling Faculty Publications and Presentations

Premature ovarian insufficiency (POI) is a common late effect of chemotherapy among survivors of adolescent and young-adult cancer (AYAC). Given on the widespread use of Chinese herbal medicine (CHM) in restoring individual health, we performed a cohort-based nested patient-control study with the aim of exploring the effect of blending CHM into routine care on the reduction of chemotherapy-induced POIrisk among females with AYAC.


Three-Dimensional Printing Of Calcium Phosphate-Mesoporous Bioactive Glass Scaffolds For Bone Tissue Engineering, Ana Beatriz Gomes De Carvalho, Lais Medeiros Cardoso, Igor Paulino Mendes Soares, Joyce Rodrigues De Souza, Arpita Roy, Prabaha Sikder, Et. Al. Dec 2025

Three-Dimensional Printing Of Calcium Phosphate-Mesoporous Bioactive Glass Scaffolds For Bone Tissue Engineering, Ana Beatriz Gomes De Carvalho, Lais Medeiros Cardoso, Igor Paulino Mendes Soares, Joyce Rodrigues De Souza, Arpita Roy, Prabaha Sikder, Et. Al.

Mechanical Engineering Faculty Publications

Calcium phosphate cements (CPCs) and biomaterials, such as mesoporous bioactive glass (MBG), are critical for bone tissue engineering. This study aimed to 3D-print CPC scaffolds modified with MBG to enhance their osteogenic potential and regenerative ability. MBG powder was synthesized and characterized using transmission electron microscopy (TEM), X-ray diffraction (XRD), and nitrogen adsorption-desorption techniques. A commercial CPC ink (hydroxyapatite/alpha-tricalcium phosphate) was mixed with 5% MBG (w/w; CPC/MBG), and, after rheological assessment, the mixture was used to obtain scaffolds via 3D printing. These scaffolds were then tested for chemical, morphological, and mechanical properties, as well as ion release analysis. Unmodified CPC …


Factors Influencing Hispanic Students Obtaining A Post-Secondary Degree, Amy Paz Dec 2025

Factors Influencing Hispanic Students Obtaining A Post-Secondary Degree, Amy Paz

Masters Theses (Archived)

This qualitative case study explored the factors influencing Hispanic students’ decisions to pursue post-secondary education. Guided by the research question, What factors influence Hispanic students’ decision on obtaining a post-secondary college degree? the study examined the lived experiences of five participants who pursued various pathways, including two- and four-year institutions, vocational training, and workforce entry. Semi-structured interviews revealed four central themes: (1) influence and motivation, (2) cultural and educational background, (3) challenges and barriers, and (4) the importance of a college degree. Findings highlighted the significant role of family as both motivators and guides, the influence of cultural values, and …


3d Mri-Guided Near-Infrared Spectroscopic Tomography For Imaging Breast Cancer, Mengyang Zhao Dec 2025

3d Mri-Guided Near-Infrared Spectroscopic Tomography For Imaging Breast Cancer, Mengyang Zhao

Dartmouth College Ph.D Dissertations

While dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) is widely recognized as the most sensitive modality for breast cancer detection, it has notable limitations, including a high false-positive rate and potential safety concerns associated with gadolinium (Gd) contrast agents. Consequently, there is growing interest in alternatives that rely on endogenous contrast. To address this need, the overall goal of this thesis is to develop and evaluate a concurrent MRI-guided near-infrared spectroscopic tomography (MRg-NIRST) platform capable of achieving reliable diagnostic performance without the use of contrast agents. In this multi-modality imaging approach, MRI provides high-resolution anatomical information about breast tissue composition, while …


Program Agenda 12-16-25, Angela Brock Dec 2025

Program Agenda 12-16-25, Angela Brock

Programs Committee (PC)

No abstract provided.


Approved Programs 12-16-25, Angela Brock Dec 2025

Approved Programs 12-16-25, Angela Brock

Programs Committee (PC)

No abstract provided.


Prevalence And Factors Associated With Regular Fast-Food Consumption Among Adults In The Uae: A Cross-Sectional Study, Ala Al Rajabi, Rafiq Hijazi, Lynne Alexandra Kennedy Dec 2025

Prevalence And Factors Associated With Regular Fast-Food Consumption Among Adults In The Uae: A Cross-Sectional Study, Ala Al Rajabi, Rafiq Hijazi, Lynne Alexandra Kennedy

All Works

Objectives: To assess the prevalence and identify sociodemographic predictors of regular fast-food consumption (R-FFC) among United Arab Emirates (UAE) adults to inform public health nutrition responses to growing diet-related ill health in the region. Design: This is a descriptive cross-sectional study using purposive, convenience sampling. Data were collected using an online survey adapted from two validated surveys and distributed via social media platforms. R-FFC was defined as visiting a fast-food restaurant to eat ≥ 2 times/week. Pearson’s χ 2 tests and multiple binary logistic regression models were used to investigate prevalence and predictors of R-FFC. All statistical significance was considered …


Ucc Minutes 12-16-25, Angela Brock Dec 2025

Ucc Minutes 12-16-25, Angela Brock

UCC Agendas/Minutes

No abstract provided.


Disposal, Yihan Su Dec 2025

Disposal, Yihan Su

Theses

Disposal is a mixed-media animated short film created as a graduate thesis project. The story explores the protagonist’s search for meaning in life and his defiance of a predetermined fate. At the beginning, he is an ordinary, guileless figure without remarkable qualities. In his world, life revolves around constant competition, and one’s worth is measured by their position on a ranking board. Only the top three may pass through the golden gate, a symbol of transcendence. Others must continue the endless cycle of contests, while the lowest seven face incineration in the Disposal. Despite his efforts, the protagonist falls into …


Wdfy4-Dependent Cross-Presentation Proceeds Via A Vacuolar Antigen-Processing Route, J Luke Postoak, Alyssa Koch, Sicong Shan, Ray A Ohara, Suin Jo, Jing Chen, Pritesh Desai, Feiya Ou, Magdalena Kraft, Michael S Diamond, Sunkyung Kim, Theresa L Murphy, Kenneth M Murphy Dec 2025

Wdfy4-Dependent Cross-Presentation Proceeds Via A Vacuolar Antigen-Processing Route, J Luke Postoak, Alyssa Koch, Sicong Shan, Ray A Ohara, Suin Jo, Jing Chen, Pritesh Desai, Feiya Ou, Magdalena Kraft, Michael S Diamond, Sunkyung Kim, Theresa L Murphy, Kenneth M Murphy

2020-Current year OA Pubs

The intracellular processing route used by type I conventional dendritic cells (cDC1) for cross-presentation of viral- or tumor-associated antigens remains controversial. One model proposes that captured antigens exit from damaged phagolysosomes and enter the cytosol, where they are processed for presentation by MHC class I molecules (MHC-I). This model relies on proteasomal degradation and TAP-dependent peptide transport into the endoplasmic reticulum (ER) for loading by the peptide loading complex (PLC). An alternative model proposes a vesicular route in which captured antigens are retained and processed within an endocytic compartment. A compelling argument favoring the cytosolic model is the dramatic loss …


Homemade For Change: Addressing The Barriers To Home Cooking Among Emerging Adults For Better Health, Finances, And Well-Being, Sarida Smitthimedhin Dec 2025

Homemade For Change: Addressing The Barriers To Home Cooking Among Emerging Adults For Better Health, Finances, And Well-Being, Sarida Smitthimedhin

Masters Theses

This study investigates how a visual approach—combining design, photography, and illustration with nutrition—can encourage home cooking. In today’s fast-paced society and overabundance food culture, many emerging adults struggle to prepare meals at home. This study examines how food industry practices and cultural trends shape the eating habits of emerging adults by exploring the reasons behind the decline in home cooking and its adverse effects on health, finances, well-being, and the environment.

Although research indicates that most adults recognize that home cooking is the healthiest choice, they often do not practice it, citing time and lack of cooking knowledge as their …


Grounding Human Value: A Critical Evaluation Of Naturalism And A Defense Of Christianity As The Basis For Human Value And The Moral Status Of The Unborn, Jacob Vazquez Dec 2025

Grounding Human Value: A Critical Evaluation Of Naturalism And A Defense Of Christianity As The Basis For Human Value And The Moral Status Of The Unborn, Jacob Vazquez

Masters Theses

This thesis will explore the grounding of personhood and seeks to convince atheist readers who adhere to naturalism that abortion is wrong because human beings are made in the image of God, as the Christian doctrine of the Imago Dei teaches. This will be done by taking the reader on a journey or a map, in which various secular (non-religious) destinations are visited before finally reaching the final theological conclusion as presented above. The evidence culminated from each of the secular stops will end up supporting the argument from the Imago Dei against abortion.

For instance, Chapter 1 will consist …


Faith-Based Practices And Health: The Role Of Faith-Based Guided Meditation In Managing Type 2 Diabetes, Willie M. Velasquez Dec 2025

Faith-Based Practices And Health: The Role Of Faith-Based Guided Meditation In Managing Type 2 Diabetes, Willie M. Velasquez

Doctoral Dissertations and Projects

The purpose of my study was to investigate how faith-based guided meditation influences health management behaviors and individuals with Type 2 diabetes. Specifically, I examined its effects on glycemic control, stress levels, and emotional well-being. Current diabetes management approaches, such as medication, diet, and exercise, often fail to address psychological and spiritual aspects critical for effective self-management. Grounded in the Biopsychosocial Model of Health, this mixed-method study explored the potential of faith-centered meditation to promote improved self-care behaviors and enhance emotional resilience. The research included a sample size of 40 participants, male and female, ages 18-60, of diverse backgrounds, divided …


Covid-19 Event Impact: Religious/Spiritual Coping And Posttraumatic Growth In Adult Female Survivors Of Childhood Sexual Abuse, Mindy Barrett Perlman Dec 2025

Covid-19 Event Impact: Religious/Spiritual Coping And Posttraumatic Growth In Adult Female Survivors Of Childhood Sexual Abuse, Mindy Barrett Perlman

Doctoral Dissertations and Projects

The COVID-19 pandemic presented a unique collective trauma that has disproportionately impacted vulnerable populations, including adult female survivors of childhood sexual abuse (CSA). This quantitative, non-experimental, correlational study examined the relationship between spiritual/religious coping and posttraumatic growth (PTG) among this population, while also exploring the psychological impact of the COVID-19 pandemic and the mediating role of religious/spiritual coping. Grounded in Tedeschi and Calhoun’s Posttraumatic Growth Theory and Pargament’s Religious Coping Theory, this study utilized the Posttraumatic Growth Inventory (PTGI), the Brief Religious Coping Scale (Brief RCOPE), and the Impact of Event Scale–Revised (IES-R) adapted for COVID-19 to assess trauma exposure, …


Nurturing Mature Adolescents: An Advanced Psycho-Educational Program Exploring The Effectiveness Of Social-Emotional Competence Among Adolescent Middle School Students- Phase I Action Research Pilot Study, Nkeiruka M. Maduike Dec 2025

Nurturing Mature Adolescents: An Advanced Psycho-Educational Program Exploring The Effectiveness Of Social-Emotional Competence Among Adolescent Middle School Students- Phase I Action Research Pilot Study, Nkeiruka M. Maduike

Doctoral Dissertations and Projects

Adolescence is a critical period marked of development marked by increased emotional and social challenges that shapes adolescents’ future well-being. This Phase I qualitative action research pilot study examined the effectiveness of the Nurturing Mature Adolescents (N.M.A.) psychoeducational program in enhancing emotional regulation and interpersonal skills among middle school students. Guided by Bandura’s Social Learning Theory, nine participants aged 11–14 engaged in a four-week intervention featuring structured lessons, observational learning, and self-efficacy strategies. Pre- and post-interviews and demographic surveys were analyzed using descriptive, In Vivo, process, emotion, and evaluation coding methods. Findings revealed consistent improvements in emotional awareness, self-regulation, communication, …


Mbnl Loss Of Function In Smooth Muscle As A Model For Myotonic Dystrophy Associated Gastrointestinal Dysmotility, Janel A M Peterson, Jesus A Frias, Andrew N Miller, Krishnakant G Soni, Yi Zhang, Zheng Xia, John W Day, Geoffrey A Preidis, Thomas A Cooper Dec 2025

Mbnl Loss Of Function In Smooth Muscle As A Model For Myotonic Dystrophy Associated Gastrointestinal Dysmotility, Janel A M Peterson, Jesus A Frias, Andrew N Miller, Krishnakant G Soni, Yi Zhang, Zheng Xia, John W Day, Geoffrey A Preidis, Thomas A Cooper

Faculty, Staff and Students Publications

Myotonic dystrophy type 1 (DM1) is the most common adult-onset muscular dystrophy and severely affects multiple organ systems, including the brain, heart, skeletal muscle, and gastrointestinal (GI) tract. Despite 80% of individuals with DM1 experiencing GI dysfunction that affects their daily life, the mechanisms of GI dysmotility in DM1 remain an understudied aspect of the disease. DM1 is caused by a CTG repeat expansion in the DMPK gene that, when expressed as an expanded CUG repeat RNA, sequesters and reduces the activity of the muscleblind-like (MBNL) RNA-binding protein family. We developed a mouse line with conditional, smooth muscle-specific knockout of …


Anvilstorm: The Dweller's Crown, Todd Gaige Dec 2025

Anvilstorm: The Dweller's Crown, Todd Gaige

Masters Theses

The thesis explores a personal vision for the original manuscript of The Dweller’s Crown, and the impact of setting in literature and world-building. The thesis also shares a variety of characters and how they represent themes of belonging, acceptance, unity, faith, and friendship. From the very beginning, the strong bonds between Araad, Thomble, Atlee, Sylvan, and Mereth distinguish the world of Thir Thodim apart. This thesis and the following chapters focus on the characters' deep desire to protect their beloved world. It is through their faith in one another and shared goals of survival and preservation that they set out …