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Moral Progress In Legal Doctrine, Philip Petrov

Faculty Scholarship

This article integrates the concept of moral progress – here, moral improvement in the thinking and behavior of individuals over time – into the study of legal doctrine. The article first presents a naturalistic account of what moral progress is and describes three of its most historically and analytically important forms: (1) moral circle expansion, (2) moral domain expansion, and (3) increasing sensitivity to proportionality. The article then analyzes three historical developments in U.S. tort law that qualify as instances of moral progress: (1) the partial demise of the “suicide rule” beginning around the 1980s (according to …

Crispr-Cas9: Transforming Biomedical Technology Through Gene Editing, Zaina Issa

A with Honors Projects

The research paper describe the gene editing technique CRISPR-Cas9 and the implications of its use in different fields, including medicine and agriculture.

Examining The Psychosocial Impact Of Having An Adolescent Sibling With A Leukemia Diagnosis, Jordan A. Barczak

PCOM Psychology Dissertations

The current research regarding the impact of having a sibling undergoing cancer treatment is inconsistent and limited in scope. The current study explored the psychosocial effects, including peer relationships, academic outcomes, and overall mood in siblings of children with a cancer diagnosis. This study also explored the interaction patterns between children, their siblings with a leukemia diagnosis, and other members of the family. The participants of this study consisted of five youth from different families with a child or adolescent sibling with a leukemia diagnosis. The participants were recruited via social media and other community outreach avenues. Participants were between …

Evaluating Motivation In Stem Education: A Positive Self-Talk Intervention, Tiffany L. Copeland

PCOM Psychology Dissertations

This study evaluated a social-emotional learning intervention that taught positive self-talk to high school students from underrepresented minority groups in science, technology, engineering, and math (STEM). The setting of this study was a place-based program that immersed students in hands-on STEM activities while located in Philadelphia’s life science hub. Before taking a science assessment, students set effort-based goals and learned to say self-talk statements such as “I will give my best effort” and “Even when it's hard, I will give 100%.” This mixed-methods program evaluation compared pre- and post-intervention data using a paired-samples t-test, linear regression, and correlation analyses. Data …

The Ai Study Partner: Medical Students, Self-Directed Learning, And Individual Learning Plans, Paula Ann Hawks

Dissertations and Theses

Self-directed learning (SDL) was well-documented in many educational settings, including medical schools. However, how students incorporated SDL and independent learning plans (ILPs) in undergraduate medical education received little attention. Generative AI (GenAI) encompassed a rapidly expanding field, but medical student use was underexplored. This present study examines student perceptions of SDL, ILPs, and the use of GenAI in undergraduate medical education, particularly in preparation for the USMLE Step 1. Using an action research design, qualitative data were collected via semi-structured focus groups, individual interviews, and ILP document review. Fifteen participants were in focus groups, 13 of whom then completed individual …

A Mixed Methods Study On Mexican American Satisfaction And Perception Of Clinical Trials, Grace Manzo

Dissertations and Theses

In the United States, the Food and Drug Administration sets expectations on the collection and reporting of race and ethnicity data. Ethnic data for Mexican Americans is often reported as “Hispanic or Latino.” Mexican Americans make up a significant percentage of “Hispanic or Latinos,” however, they remain significantly underrepresented in clinical trials. Grounded in Expectation-Disconfirmation Theory (EDT) and Social Cognitive Theory (SCT), this mixed-methods study investigates the relationship between satisfaction and perception of Mexican Americans who have participated in an ophthalmology clinical trial. This research aimed to understand the relationships among satisfaction with the clinical trial process, patient-reported outcomes, and …

Effects Of Hurricane Weather Events On Perceived Stress, Academic Motivation, And Resilience In College Students From Louisiana, Courtney Renee Harrington

Dissertations and Theses

In the fall semester of 2020, five hurricanes were projected to make landfall along the coast of Louisiana. The following fall semester of 2021, Hurricane Ida, a major category 4 storm landed and wreaked havoc among Louisiana’s coastal universities. The purpose of this study was to assess the effects of hurricane events on students’ perceived stress, academic performance, and resilience. It was hypothesized that students affected by the landfall of a hurricane would have increased stress, decreased academic motivation, and decreased resilience compared to normative college students. A cross-sectional survey was administered at two southern Louisiana universities as well as …

Interactional Synchrony In Mother-Infant Dyads: Developmental Changes And The Impact Of Maternal Emotion Dysregulation Over Time, Jessica Taylor Kelly

Dissertations and Theses

Infancy is a period of rapid development, while motherhood is often a time of heightened emotionality (Bjelica et al., 2018; Leclère et al., 2014). Synchrony between mother and infant is one of the earliest bonding experiences, with short- and long-term implications for the infant’s development and the mother-infant relationship (Leclère et al., 2014). However, little research has characterized developmental shifts in mother-infant synchrony. Maternal emotion dysregulation is likely to influence mother-infant synchrony (Doba et al., 2022; Lotzin et al., 2015, 2016). Yet little research has evaluated the impact of maternal emotion dysregulation on mother-infant synchrony over time. This project aims …

The Neuroprotective And Synergistic Effects Of Carbamoylated Erythropoietin And Insulin-Like Growth Factor-1 In Alzheimer's Disease, Morgan Jean Rothschadl

Dissertations and Theses

Alzheimer’s disease (AD) is a prominent neurodegenerative disease characterized by a decline in cognitive functioning. While current FDA-approved therapeutics exist, they fall short in creating significant and long-lasting improvements to cognition. A newer approach using neurotrophic factors has shown promising effects on improving cognition in clinical trials. Neurotrophic factors are secreted proteins that have multimodal effects in the brain, including supporting cell survival and functioning. Two neurotrophic factors of interest are carbamoylated erythropoietin (CEPO) and insulin-like growth factor-1 (IGF-1), and the goal of this study was to understand the synergistic and neuroprotective effects of CEPO and IGF-1 in AD. We …

The Efficaciousness Of Generative Ai For Integrated Stem Planning And Its Impact On Stem Teacher Self-Efficacy, Julie Ann Olson

Dissertations and Theses

With evolving workforce needs, global challenges, and national science education initiatives calling for STEM instruction with purposeful connections between the four domains, there is a need for methods to support educators facing the challenges this pedagogical approach presents. Challenges may weaken teachers' self-efficacy, potentially reducing the probability that an integrated STEM (I-STEM) pedagogy would be sustained in the classroom. There is limited research addressing how generative artificial intelligence (GAI) has been used for I-STEM lesson development, combined with its effects on I-STEM teaching self-efficacy (SE) grounded in social cognitive theory. This study investigated how GAI influences I-STEM teaching SE, when …

Avian Use Of Early Successional Riparian Forest Along The Missouri River: What Do We Lose By Managing For Plovers And Terns?, Stephanie Nefas

Dissertations and Theses

Riparian ecosystems provide habitat for birds throughout their annual cycle, yet flow regulation along major rivers like the Missouri River has reduced early successional riparian forests. Following historic flooding in 2011, set-aside areas within the Missouri National Recreational River (MNRR) were established to allow natural riparian vegetation succession on newly created sandbars. I evaluated the value of these early successional forests for birds over three breeding seasons (2018–2020) and four migration periods (2020–2021). During migration, standardized point counts documented 7,462 individual birds representing 114 species across 828 surveys. Avian diversity was positively correlated with vertical habitat complexity, with the canopy …

The Path To Information Literacy: From Finding A Topic To Writing An Annotated Bibliography, Robyn Hartman, Claire Nickerson, Heather P. Vandyne

All Open Educational Resources

This book is an adaptation of Ohio State University's Choosing & Using Sources: A Guide to Academic Research. It has been revised with a new introduction and learning objectives and section summaries. It also includes sections on common research assignments such as research plans, research logs, note-taking, and annotated bibliographies. The sections on evaluating resources have been expanded to include lateral reading with SIFT (Stop, Investigate the source, Find better coverage, Trace sources) and evaluation with CRAAP (Currency, Relevance, Authority, Accuracy, Purpose), the 5Ws (Who What When Where Why), and BEAM (Background, Exhibit, Argument, Method). Sections on generative AI have …

Rural Black Church Leadership And Community Development In Midwest Illinois, Derrick Smith

Dissertations of Practice

This qualitative study examines the role of a rural Black church in leadership development and community sustainability within a Midwestern Illinois town. While extensive scholarship documents the historical significance of the Black church in civil rights, political mobilization, and social advocacy, limited research explores the founding of contemporary Black churches and the intentional processes through which they develop leaders and support community sustainability in rural or small-town settings. This study addresses that gap by investigating the establishment and evolution of New Hope Missionary Baptist Church (NHMBC) in DeKalb, Illinois, and its impact on leadership development and Black community development.

Guided …

Preparing Students For What Comes Next: A Qualitative Study Of District Approaches To Postsecondary And Career Readiness, Amanda C. Pelsor

Dissertations of Practice

PREPARING STUDENTS FOR WHAT COMES NEXT: A QUALITATIVE STUDY OF DISTRICT APPROACHES TO POSTSECONDARY AND CAREER READINESS

This qualitative study examines how Illinois school districts support students’ readiness for postsecondary success and career planning and exploration. Despite longstanding state and federal efforts to improve college and career readiness, many students continue to face challenges after high school, including lack of workforce readiness, underpreparedness for postsecondary education, unclear career pathways, and difficulty navigating complex transitions. Using semi-structured interviews, this study explores how districts conceptualize and implement career readiness frameworks, the ways readiness work is embedded within district systems, and the barriers …

The Lived Experiences Of Lgbtqia+ Community College Students Regarding Their Science Identity And Sense Of Belonging, Moria L. Nagy

Dissertations of Practice

A minoritized group that struggles in science, though it spans many genders, and racial/ethnic identities, are LGBTQIA+ individuals. These students face challenges such as a lack of social acceptance manifesting in microaggressions, prejudice and violence, as well as challenges in their studies due to non-inclusive curriculum. These challenges impact the learning experience of these students and reduce retention rates, especially in the sciences. In addition, the climate of social acceptance for LGBTQIA+ students at community colleges is worse than that of four-year institutes. Science identity is a complex composition of recognizing oneself as a science person, or a competent practitioner …

Assessing Sandfly & Mosquito Abundance, Richness, And Diversity In Villaflora, Ecuador: Linking Disease Vectors To Disease Risk, Carlia Rose Lopez

Student Scholarship

No abstract provided.

Superelectrophile Promoted Synthesis Of Heterospirocycles, Mariam A. Adegbenro

Graduate Research Theses & Dissertations

Spirocycles are important scaffolds with a wide range of applications in material science as well as in medicine. The introduction of a heteroatom into the spirocyclic framework can improve its electronic, photophysical, and structural properties. Various reports have been published on the incorporation of atoms other than carbon into the spirocycle. The work outlined in this dissertation involves the development of synthetic methodologies for the synthesis of hetero-spirocycles via superacid-promoted cyclization reactions. These concepts are summarized in Chapter 1.

Chapter 2: Aromatic imines were prepared from 9-fluorenone and azafluorenones, and these substrates were reacted in the Brønsted superacid, triflic acid, …

Effects Of Desiccation On Invasive Faucet Snail (Bithynia Tentaculata) And Trematode Survival, Elise Marie Jordahl

Graduate Research Theses & Dissertations

Parasitism is one of the most common and diverse life history strategies, yet relatively little is known about the role of parasites as invasive species. Invasive species, which present one of the greatest threats to biodiversity, often need to overcome adverse environmental conditions as they establish and spread in new habitats. Invasive parasites are subject to these same conditions, though the effects may be mediated through their hosts. Here, I use an invasive snail and its trematode parasites to quantify the effects of desiccation on survival to better understand how processes of invasion play out in host-parasite systems. The faucet …

Photovoice Exploration Of Afghan Refugee Background Women's Food-Related Well-Being, Eileen C. Lindemann

Graduate Research Theses & Dissertations

More than 117,000 Afghans have been relocated to the United States following the U.S. military withdrawal in August 2021. Research indicates that Afghan refugees resettled in the U.S. are at increased risk of psychological distress, with Afghan women particularly susceptible compared with Afghan men, and diet-related chronic disease. However, research also shows that traditional food and eating customs foster cultural identity, social support, integration, and well-being. The purpose of this study was to collaboratively explore the food-related well-being and daily life contexts of resettled refugee participants through the photovoice method, a participatory research strategy in which participants photograph aspects of …

Personality Theories, Leswin Laubscher

Open Education Materials

Introduction to Personality Theories

Medical Image Feature Extraction And Selection Based On Inception V3 And Gini Index For Cervical Cancer Cells Identification, Rachida Assawab, Mounir Ouzir, Badreddine Benyacoub, Abderrahim Electrochemical Sensor For Tenofovir Allati, Ismail El Moudden

Research and Infrastructure Service Enterprise (RISE) Faculty Publications

Background: Cervical cancer remains the fourth most common cancer in women globally, with 604,000 new cases annually. Early detection through cytological screening is critical, but manual interpretation suffers from high false negative rates and requires expert pathologists often unavailable in resource-limited settings.

Methods: We developed a novel hybrid framework combining InceptionV3-based deep feature extraction with Gini Index feature selection for automated cervical cancer cell classification. Using the Herlev dataset (917 Pap smear images: 242 normal, 675 abnormal), we extracted 2048 deep features and applied systematic feature selection to identify optimal discriminative subsets. Comprehensive clustering analysis (K-means, K-medoid, Fuzzy clustering) validated …

Neurotensin Drives Theca Cell Migration During Ovulation In Primates, Jessica S. Miller, Megan A. G. Sage, Thomas E. Curry Jr., Diane M. Duffy

Department of Biomedical and Translational Sciences Faculty Publications

Theca cells are a critical steroidogenic cell type of the ovarian follicle and corpus luteum. The ovulatory luteinizing hormone (LH) surge (or human chorionic gonadotropin (hCG)) stimulates theca cell relocation from the stroma surrounding the dominant follicle to full integration into the developing corpus luteum. Luteinizing hormone/human chorionic gonadotropin also stimulates granulosa cells to produce local mediators of ovulation, including the peptide neurotensin (NTS). To determine if hCG-stimulated NTS regulates theca cell relocation within the ovulatory follicle, vehicle or an NTS receptor antagonist was injected into a macaque dominant follicle, and ovaries were removed 48 h after hCG administration. Additional …

P38 Mapk Is Involved In Epigenetic Regulation Of Fibrotic Genes In Replication Induced Senescence In Lung Fibroblasts, Shan Zhu, Jennifer Q. Zhou, Kan Wang, Ming-Lei Guo, Yan Sanders

Department of Biomedical and Translational Sciences Faculty Publications

Fibroblast activation is essential for tissue repair following injury; however, prolonged activation drives pathological fibrosis. Idiopathic pulmonary fibrosis (IPF), a progressive and age-associated lung disease, is characterized by aberrant fibroblast activation, with increasing evidence implicating senescent and near-senescent fibroblasts in its pathogenesis. However, the underlying mechanisms remain poorly defined. In this study, we investigated whether histone modification is involved in TGF-β1 treated lung fibroblasts and contributes to the fibrotic phenotype. Human IMR90 lung fibroblasts at low and high population doubling levels (LPDL and HPDL), as well as primary IPF fibroblasts, were used in this study. In response to TGF-β1, both …

Brief Pulses Of High-Level Fluid Shear Stress Enhance Metastatic Potential And Rapidly Alter The Metabolism Of Cancer Cells, Amanda N. Pope, Devon L. Moose, Guy O. Hudson, Hank R. Weresh, Marion R. Dykstra, Aabha Y. Joshi, Patrick Breheny, Eric B. Taylor, Michael D. Henry

Department of Biomedical and Translational Sciences Faculty Publications

Circulating tumor cells (CTCs) face challenges to their survival, including mechanical and oxidative stresses that are different from cancer cells in solid primary and metastatic tumors. The impact of adaptations to the fluid microenvironment of the circulation on the outcome of the metastatic cascade is not well understood. Here, we find that cancer cells exposed to brief pulses of high-level fluid shear stress (FSS) exhibit enhanced invasiveness and anchorage-independent proliferation in vitro and enhanced metastatic colonization/tumor formation in vivo. Cancer cells exposed to FSS rapidly alter their metabolism in a manner that promotes survival by providing energy for cytoskeletal remodeling …

Deletion Of Stim1 In Treg Cells Protects Against Lung Fibrosis And Associated Cardiovascular Complications In A Pre-Clinical Mouse Model, Nagaraja Nagre, Balaji Srinivas, Nicholas Richards, Ryan Washington, Gregory Nicholson, Yan Sanders, Beata Kosmider, Khalid Matrougui

Department of Biomedical and Translational Sciences Faculty Publications

Idiopathic pulmonary fibrosis (IPF) is a progressive and incurable lung disease characterized by excessive tissue remodeling and impaired gas exchange. Evidence highlights the critical interplay between immune regulation, calcium signaling, and redox biology implications in the pathogenesis of fibrotic lung disease. Regulatory T-cells (Tregs), known to modulate cardiovascular and immune function, are diminished in IPF, contributing to inflammation and tissue damage. Here, we demonstrate that the stromal interaction molecule 1 (STIM1), a key regulator of intracellular calcium homeostasis, is significantly upregulated in Treg cells isolated from IPF patients and mice subjected to bleomycin-induced lung injury. This upregulation is associated with …

Senescent Fibroblasts In Aging And Pulmonary Fibrosis, Sara B. Palega, Aiwei Y. Borengasser, Yan Y. Sanders

Department of Biomedical and Translational Sciences Faculty Publications

Aging is a major risk factor for many chronic lung diseases, including Idiopathic Pulmonary Fibrosis (IPF), a fatal and incurable disease characterized by progressive fibrotic remodeling. Age-associated structural alterations, impaired regenerative capacity, and dysregulated cellular signaling collectively create a pro-fibrotic microenvironment. A central driver of this pathological shift is the accumulation of senescent cells, which undergo irreversible growth arrest and develop a robust pro-inflammatory senescence-associated secretory phenotype (SASP). Emerging evidence identifies senescent lung fibroblasts as critical mediators of IPF pathogenesis. These cells promote excessive extracellular matrix deposition, myofibroblast differentiation, and tissue stiffening, while simultaneously impairing epithelial regeneration. Together, these effects …

Inhibition Of Histone Demethylase Lsd1 Suppresses Cd47 Expression And Enhances Efficacy Of Cd47 Blockade In Breast Cancer, Fengjie Jiang, Yu Shen, Bing Li, Michael Henry, Nancy Davidson, Yi Huang

Department of Biomedical and Translational Sciences Faculty Publications

Background CD47 functions as a “don’t eat me” checkpoint, inhibiting macrophage-mediated phagocytosis in triple-negative breast cancer (TNBC). While anti-CD47 therapies can restore immune surveillance, their efficacy in TNBC is often limited by immune evasion and drug development challenges.

Methods We investigated the crosstalk between the histone demethylase lysine-specific demethylase 1 (LSD1) and CD47 signaling in TNBC using in silico datasets, isogenic cell lines, conditional BRCA1 knockout models, and syngeneic mouse models. Techniques such as immunohistochemistry, multiplex immunofluorescence, immunoprecipitation, protein ubiquitination, chromatin immunoprecipitation, chemotaxis, flow cytometry, and phagocytosis assays were employed to examine the epigenetic regulation of CD47 by LSD1 and …

Supramolecular Self-Assemblies Of Ru( Ii ) Phototherapeutics: Biological Activity Of Micro- And Nano-Particles Acting As Reservoirs, Jérôme Laisney, Sarah M. Kriger, Dmytro Havrylyuk, Jason M. Unrine, David K. Heidary, Edith C. Glazer

Chemistry Faculty Publications

Ruthenium( II) coordination complexes have many appealing properties as prodrugs, but can suffer from poor aqueous solubility and short circulation times, drastically decreasing efficiency in vivo. Nanoformulations using a variety of carriers, such as inclusion in polymers/lipids or adsorption on inorganic nanoparticles have been applied to overcome this limitation, but unfortunately, these approaches raise additional concerns regarding the fate of the carriers, with potential long-term toxicity and accumulation in vital organs. Here, we present an alternative delivery strategy with formation of pure and polymer-supported supramolecular self-assemblies of Ru(II) complexes acting as ‘‘reservoirs’’. A facile preparation of size-controlled particles was achieved …

Characterization And Antimicrobial Activity Of Lignin-Derived Compounds In Ground Hurd Tissue Of Cannabis Sativa L. (Hemp) Cultivars, Jourdan E. Lakes, Anjam Sadik, Robert C. Pearce, Barbara L. Knutson, Stephen E. Rankin, Bert C. Lynn, Michael D. Flythe

Chemistry Faculty Publications

Objectives: Characterize lignin-derived compounds from the hurd of 10 fiber/grain Cannabis sativa L. cultivars and investigate the antimicrobial activity of select compounds on the wasteful ruminant bacterium, Acetoanaerobium sticklandii SR.   Methods: Hurd was processed using an aqueous ethanol solvent system and analyzed via GC-MS to identify and characterize lignin derivatives. Antimicrobial activity of the hurd and three monomers was assessed using solid (hurd) and liquid medium (monomers) bioassays against SR.   Results: 27 compounds were identified, most as monomers but a few were dimers, ethylated derivatives, and organic acids. There were approximately equal G- and S-units with substantially fewer H-units. Several …

Ai-Assisted Wheat Spike And Spikelet Detection And Density Mapping Using Multiscale Remote Sensing Data To Support Wheat Grain Yield Forecasting, Hillson Ghimire

Electronic Theses and Dissertations

Wheat grain yield is determined by the number of spikes per unit area, the number of grains per spike, and kernel weight. However, spike number and spikelets per spike are still measured predominantly through manual counting, a labor-intensive and subjective process that limits phenotyping throughput and selection intensity in modern wheat breeding programs. This thesis develops and evaluates a deep learning framework for automated, high-throughput phenotyping of wheat spike and spikelet traits across complementary imaging scales and implements the framework as a deployable platform. First, two large-scale benchmark datasets with oriented bounding box (OBB) annotations were established, comprising 48,521 spike …