Digital Commons Network^™

Investigation Of Fine-Grain Cu And Cu Alloys For Low-Temperature Hybrid Bonding Applications, Sarabjot Singh

Electronic Theses & Dissertations (2024 - present)

Hybrid bonding has emerged as a key enabler for next-generation three-dimensional (3D) integration, offering fine-pitch interconnects and improved electrical performance. However, conventional Cu–Cu hybrid bonding typically requires elevated temperatures to achieve sufficient diffusion and interface quality, posing challenges for temperature-sensitive device integration and process compatibility. This work investigates materials engineering approaches to enable low-temperature Cu–Cu bonding through both microstructure design and alloying strategies.

This work begins by examining grain refinement in Cu as a pathway to enhance diffusion through increased grain boundary density, providing efficient atomic transport without introducing additional elements. Three Cu-based systems Cu–Co, Cu–Ag, and Cu–Al were systematically …

Photo And Spatial Control Of Rna Structures And Functions: Exploring Positional Effects And Photo-Responsiveness Of Azobenzene Modified Nucleotides, Jinxi Du

Electronic Theses & Dissertations (2024 - present)

RNA molecules perform many important biological functions by forming complex three-dimensional structures stabilized by base pairing, tertiary interactions, and metal ion coordination. Because RNA function depends strongly on its structure, methods that allow reversible control of RNA conformation and activity are important for understanding RNA behavior and for potential therapeutic applications. However, achieving reversible and site-specific control of RNA structure, especially at the single-nucleotide level, remains challenging. In this dissertation, I developed and applied azobenzene-modified nucleotides as a chemical tool to enable optical and spatial control of RNA structure and function.

The first part of this dissertation focuses on establishing …

The Relationship Between State-Level Career And Technical Education (Cte) Policies And Secondary Student Enrollment In Construction, Manufacturing, And Health Sciences Cte Programs, Brittany A. Kitterman

Electronic Theses & Dissertations (2024 - present)

Across the United States, employers in construction, manufacturing, and healthcare report ongoing difficulty filling positions. These shortages have been driven by an aging workforce, increased demand, and high rates of retirement. Compounding these shortages, Federal investments such as the Infrastructure Investment and Jobs Act and the CHIPS Act have further increased demand. Career and Technical Education programs are well positioned to support workforce development and help close workforce shortages, but access and participation remain limited. Supported by Federal Perkins funding, states have enacted CTE policies to increase access and enrollment in CTE programs aligned with high-demand industries such as construction, …

Data From: Mass Mortality Of Avian Migrants In New Mexico, Usa, That Coincided With An Extreme Weather Event, Dylan M. Osterhaus, Allison J. Salas, Patricia L. Cutler, Mara E. Weisenberger, Kerry Mower, Abigail J. Lawon, Timothy F. Wright, Jeanne M. Fair, Martha J. Desmond

Fish, Wildlife, & Conservation Ecology: Datasets

No abstract provided.

Data And Code From: Migration Speed, Timing, And Long-Term Shifts In Age Structure In North American Passerines During Fall Migration, Dylan M. Osterhaus, Martha J. Desmond, Timothy F. Wright

Biology: Datasets

No abstract provided.

Autism And Homelessness: An Intersectional Case Study In Kitchener-Waterloo, Ontario, Nicole J. Mcdonald

Theses and Dissertations (Comprehensive)

Homelessness is a growing crisis in Canada, with literature suggesting autistic traits as over-represented within this population. Literature addressing intersectional experiences of autism is emerging, however there are gaps in the research surrounding intersectional experiences of autism and homelessness. Research suggests that autistic individuals may be more vulnerable to experiencing homelessness and face difficulties in exiting homelessness. This qualitative case study utilizes a Disability Justice framework to explore intersectional autistic experiences of homelessness, social service usage, and suggests recommendations on improving support for autistic individuals at risk of and experiencing homelessness. Four autistic participants with experience of homelessness and accessing …

At A Crossroads: Crisis, Vulnerability, And The Possibility Of Transformation Of Nature-Based Tourism In Canada, Brooklyn Rushton

Theses and Dissertations (Comprehensive)

We live in an era shaped by a global polycrisis, where climate change, pandemics, economic shocks, geopolitical tensions, and social inequities are converging to create complex, cascading, and compounding risks. For Canada’s nature-based tourism sector, situated at the nexus of social and ecological systems, the polycrisis both amplifies the vulnerabilities of tourism and highlights tourism’s role in perpetuating global risks. Recognizing this duality, this dissertation examines how crises amplify systemic vulnerabilities while also acting as leverage points for transformative change in Canada’s nature-based tourism sector, drawing on geography, systems thinking, resilience theory, regenerative tourism, and futures thinking scholarship.

The three …

Geovig And Purevig: Geometry-Aware Architectures For Efficient Computer Vision, Omar Ismail

Theses and Dissertations (Comprehensive)

Deploying deep learning models for medical image analysis on mobile devices requires a balance between inference latency, memory footprint, and delineating anatomical boundaries with high accuracy. While Convolutional Neural Networks (CNNs) and mobile Vision Transformers (ViTs) offer efficiency, they often struggle to model the irregular, non-local geometric structures inherent in biological tissues without incurring prohibitive computational costs. In this thesis, we introduce GeoViG (Geometric Vision Graph), an architecture that bridges the gap between efficient grid-based processing and explicit Geometric Deep Learning. GeoViG introduces a novel transition from high-resolution pixel grids to low-resolution dynamic graphs via a SpreadEdgePool operator, a geometry-aware …

Investigating The Immunostimulatory Potential Of Dsrna-Silk Nanoparticle Complexes In Melanoma, Samuel J. Peters

Theses and Dissertations (Comprehensive)

The rate of resistance to immune checkpoint inhibitor treatment in metastatic melanoma is quite high, with an overall rate of 70%. Melanoma achieves these high rates of resistance by suppressing the immune response in the tumour microenvironment (TME), making them immunologically “cold”. The type 1 interferon response could be leveraged to initiate immune responses in melanoma, making their “cold” TMEs “warm” again. Double-stranded ribonucleic acids (dsRNAs) are potent activators of an innate immune response; however, they are susceptible to degradation by nucleases present in the body and need a carrier. Silk nanoparticles (SNPs) are an ideal drug-delivery platform as they …

Investigation Of Mercury Bioaccessibility In Subsistence Fishes From The Canadian Subarctic, Kiran Mateo Sharma Mr

Theses and Dissertations (Comprehensive)

Fish consumption is the primary pathway for human exposure to methylmercury (MeHg), a global contaminant of concern known to cause adverse health effects. Fort Albany First Nation, a remote Indigenous community in northern Ontario that relies on fish for both subsistence and cultural practices, has expressed concern regarding the safety of local fish consumption. Community members and leaders have communicated several priorities for scientific research that are the foundation of this thesis. Specifically, consumers of wild-caught fish have asked how traditional cooking methods may affect mercury concentrations in fish, and how mercury concentrations in little-studied organs, such as liver and …

The Power Of Letting Go: The Role Of Goal Adjustment Capacities Across Future And Daily Perspectives Of Chronic Illness, Alexandra Dagher, Meaghan Barlow

Theses and Dissertations (Comprehensive)

Goal adjustment capacities are self-regulatory processes that protect psychological well-being by allowing individuals to disengage from unattainable goals and reengage in new attainable ones. Although research has shown that these capacities are beneficial in the context of chronic illness, little is known about how their effectiveness may differ across various aspects of the chronic illness experience. The present research consisted of two distinct yet complementary studies examining the role of goal adjustment capacities in two chronic illness contexts. Study 1 (N = 149) prompted participants to imagine the future progression of a chronic illness, whereas Study 2 (N …

Eelgrass Distribution In The Great Bay Estuary And Piscataqua River For 2025: Final Project Report Submitted To The Piscataqua Region Estuaries Partnership, Michael Routhier, Raymond Grizzle, Taylor Goddard, Krystin Ward

PREP Reports & Publications

No abstract provided.

Beyond Bans: A Travel Distance-Based Approach To Estimating The Effects Of Dobbs V. Jackson Women’S Health Organization On Fertility And Labor Supply, Enya Kamadolli

CMC Senior Theses

The Dobbs v. Jackson Women’s Health Organization decision had highly heterogeneous effects on abortion access across U.S. states, variation I exploit to identify causal effects on fertility and labor supply. Rather than a binary “total ban” indicator, I construct a continuous treatment measure based on changes in distance to the nearest legal abortion provider between 2021 and 2023, and apply a difference-in-differences design to state-level panel data. Effects are attenuated and imprecise in the South, consistent with diminishing marginal effects at large distances. In non-Southern states, I find that a 100 km increase in distance raises total births by about …

Polyfluoroalkyl Substances And Altered Glucose Homeostasis In Adolescents Following Bariatric Surgery, Elizabeth Costello, Brittney O Baumert, Zhenjiang Li, Vishal Midya, Shudi Pan, Justin R Ryder, Thomas H Inge, Todd M Jenkins, Stephanie Sisley, Stavra A Xanthakos, Anita Courcoulas, Douglas I Walker, Nikos Stratakis, Damaskini Valvi, Scott M Bartell, Angela L Slitt, Rohit Kohli, Sarah Rock, Michele A La Merrill, Sandrah P Eckel, Max T Aung, Rob Mcconnell, David V Conti, Lida Chatzi

Children’s Nutrition Research Center Staff Publications

Objectives: Bariatric surgery is an effective treatment for severe obesity and associated metabolic comorbidities. Exposure to polyfluoroalkyl substance (PFAS) before bariatric surgery may attenuate improvements in glucose metabolism and explain some of the heterogeneity in post-surgery outcomes.

Design: This is an observational cohort study.

Methods: Adolescents (n = 186) enrolled in the Teen-Longitudinal Assessment of Bariatric Surgery study were included. Eight-PFAS congeners were measured in plasma before surgery. Linear and logistic regressions were used to examine cross-sectional associations between log2-transformed PFAS (ng/mL) and fasting glucose, insulin, hemoglobin A1c (HbA1c), and homeostatic model assessment for insulin resistance (HOMA-IR). Linear mixed …

Examining Widely Held Propositions On Human Dietary Protein Needs And Benefits: A Critical Review Of The Science That Shapes Both The Data And Our Understanding Of An Essential Macronutrient, Mitchell M Kanter, Sally Aaron, Steven N Austad, Andrew W Brown, Nicholas A Burd, Wayne W Campbell, Mark Cope, Teresa A Davis, John W Erdman, Miguel Freitas, Kristen Hicks-Roof, Samuel Klein, Wantanee Kriengsinyos, Dudley W Lamming, Donald K Layman, Heather J Leidy, Kevin C Maki, Richard D Mattes, Shalene Mcneill, Daniel R Moore, Stefan M Pasiakos, Stuart M Phillips, David Raubenheimer, Wendy Reinhardt, Nancy R Rodriguez, Stephen Simpson, Hans H Stein, Luc J C Van Loon, Connie M Weaver, David B Allison

Children’s Nutrition Research Center Staff Publications

The essentiality of protein in the human diet is unequivocal. Yet researchers, clinicians, and lay people often believe numerous propositions about dietary protein despite insufficient supporting or refuting data in some instances. To address this disconnect, and to "pressure-test" current beliefs about dietary protein, the Indiana University School of Public Health-Bloomington convened a workshop in February 2025 titled "Human Dietary Protein Needs and Benefits: A Critical Assessment of Postulated Propositions." More than 20 international experts discussed (1) methodologic issues affecting data acquisition and interpretation; (2) "optimal" dietary protein intakes and effects on muscle protein synthesis rates, muscle protein accretion, …

Limosilactobacillus Reuteri Alleviates Proinflammatory T-Cell-Mediated Liver Injury And Transcriptomic Changes In Immunocompromised Mice, Ana Fadhel Alvarez, Zheng Yin, Beanna Okeugo, Alexander Banerjee, Meng Luo, Christopher M Taylor, Salomea Giorgberidze, Vaishali Harne, Rambabu Majji, Melissa N Munroe, Ji Ho Suh, Stephen T C Wong, Kang Ho Kim, Hari Krishna Yalamanchili, Suhair Al Salihi, Jon Marc Rhoads, Yuying Liu

Children’s Nutrition Research Center Staff Publications

Background: A deficiency of immunosuppressive regulatory T cells, as seen in scurfy (SF) mice or in IPEX syndrome in humans, can lead to multiorgan inflammation. Oral administration of the probiotic Limosilactobacillus reuteri Deutsche Sammlung von Mikroorganismen und Zellkulturen GmbH (DSM) 17938 prolongs survival and reduces Th1- and Th2-associated inflammation in SF mice. It remains unclear how DSM 17938-educated SF-CD4+ T cells modulate T-cell-liver communication.

Methods: To characterize CD4+ T cells from SF mice orally administered DSM 17938 (Prob-SF-CD4+ T cells) and to compare them with CD4+ T cells from SF mice (SF-CD4+ T cells), cells isolated from SF spleens were …

Cross-Sectional And Longitudinal Relationships Between Abdominal Fat Depots And Cardiometabolic Risk In A Sample Of Mexican Adolescents, Luis Ortíz-Hernández, Erica G Soltero, Miguel Camejo, Jesús Valdes

Children’s Nutrition Research Center Staff Publications

Background: The relationship between abdominal fat depots and cardiometabolic risk among youth is inconclusive due to the cross-sectional nature of existing studies and limitations in assessment methods. In this study, we examined cross-sectional and longitudinal associations of subcutaneous adipose tissue (SAT) and visceral adipose tissue (VAT) with cardiometabolic risk indicators among Mexican adolescents.

Methods: Participants (n = 169 at baseline and 134 at follow-up) were assessed for diastolic or systolic blood pressure (DBP or SBP), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), triglycerides, glucose, and insulin. VAT and SAT were measured using magnetic resonance imaging. Measures …

Sustainable Community-Wide Model To Enhance Cancer Data Usage And Utility, Emily S Boja, Mousumi Ghosh, Ying Huang, Tung-Shing Mamie Lih, Rawan Shraim, Gregory Wheeler, Diana Thomas, Rakesh Khanna, Stephanie Sandor, Jinghui Zhang, Sapna Oberoi, Nicolas J Llosa, Aditya Suru, Fernanda Silva Michels, Eric Durbin, Anna Fernandez, Lucy Han, James Galbraith, Yin Lu, Brian Furner, James H Tanis, Michael Watkins, David Higgins, Gavriel Matt, Xin Zhou, Yang Li, Marcin Cieslik, Jamie Estill, Michael Sierk, Yanling Sun, Weiping Ma, Joseph Flores-Toro, Freddie Pruitt, Subhashini Jagu, Elmer A Fernández, Daniela Orschanski, Stephanie J Spielman, Jaclyn Taroni, Trinh Nguyen, Brian Capaldo, Erin Beck, Tanja Davidsen, Johanna Goderre Jones, Minghong Ward, Anne Sturcke, Jennifer M Torres Del Valle, Sean Hanlon, Danielle Daee, Brandon Wright, Nathaniel Boyd, Heather Basehore, Liang Liu, Ying Hu, Daoud Meerzaman, Huiqing Li, Ying Wu, Gregory H Reaman, Erin Rudzinski, Jack F Shern, Brigitte Widemann, Warren Kibbe, Jaime Guidry Auvil

Children’s Nutrition Research Center Staff Publications

Despite vast investments in data collection, generation, and sharing from childhood cancer studies, for example, Gabriella Miller Kids First Research Program, Childhood Cancer Data Initiative, and other efforts, secondary use of data remains a challenge especially for rare diseases. The National Cancer Institute (NCI) Office of Data Sharing (ODS) aimed to promote FAIR (Findable, Accessible, Interoperable, Reusable) data sharing practices to enhance data utility, accelerate discovery, and foster interdisciplinary collaboration. NCI ODS launched its inaugural Data Jamboree focusing on childhood cancer alongside its third Annual Symposium in September 2025. Over 120 participants with diverse backgrounds coalesced into 23 multidisciplinary teams …

Senolytic-Resistant Senescent Cells Have A Distinct Sasp Profile And Functional Impact: The Path To Developing Senosensitizers, Utkarsh Tripathi, Masayoshi Suda, Vagisha Kulshreshtha, Bryan T Piatkowski, Allyson K Palmer, Nino Giorgadze, Christina Inman, Nathan Gasek, Ming Xu, Kurt O Johnson, Tamar Pirtskhalava, Selim Chaib, Larissa P G Langhi Prata, Yi Zhu, Renuka Kandhaya-Pillai, Stefan G Tullius, Saranya P Wyles, Rambabu Majji, Hari Krishna Yalamanchili, David B Allison, Tamar Tchkonia, James L Kirkland

Faculty, Staff and Students Publications

The senescent cell (SC) fate is linked to aging, multiple disorders and diseases, and physical dysfunction. Senolytics, agents that selectively eliminate 30%-70% of SCs, act by transiently disabling the senescent cell antiapoptotic pathways (SCAPs), which defend those SCs that are proapoptotic and pro-inflammatory from their own senescence-associated secretory phenotype (SASP). Consistent with this, a JAK/STAT inhibitor, Ruxolitinib, which attenuates the pro-inflammatory SASP of senescent human preadipocytes, caused them to become "senolytic-resistant". Administering senolytics to obese mice selectively decreased the abundance of the subset of SCs that is pro-inflammatory. In cell cultures, the 30%-70% of human senescent preadipocytes or human umbilical …

Correction: Establishing Standardized Transthoracic Echocardiography Reference Ranges For Mouse Models: Insights Into The Impact Of Anesthesia, Sex, And Age, Manuela A Oestereicher, Christopher S Ward, Elida Schneltzer, Susan Marschall, Helmut Fuchs, Valerie Gailus-Durner, Ghina Bou About, Mohammed Selloum, Hamid Meziane, Michelle Stewart, Lydia Teboul, Clare Norris, Dale Pimm, Marina Kan, Federico López Gómez, Robert Wilson, Mayra Monroy, Sheraz Pasha, Eva Zabrodska, Jan Prochazka, David Pajuelo Reguera, Zuzana Nichtova, Yann Herault, Sara Wells, Helen Parkinson, Jason D Heaney, Radislav Sedlacek, Xiang Gao, Martin Hrabe De Angelis, Nadine Spielmann

Faculty, Staff and Students Publications

This corrects the article "Establishing standardized transthoracic echocardiography reference ranges for mouse models: insights into the impact of anesthesia, sex, and age" in volume 12, 1695034.

Titanium Hypersensitivity As Possible Cause Of Dental Implant Failures, William J. Maloney D.D.S., Pg Certmeded, Facd, George Raymond D.D.S., Facd, Maura Maloney D.D.S.

The New York State Dental Journal

For many decades, titanium implants have achieved a remarkably high success rate. However, there are cases in which osseointegration does not occur as predicted or desired. In these cases, an analysis of the factors that led to the implant failure must be conducted. There are multiple, widely accepted potential causes of such implant failures. Today, one must also consider titanium hypersensitivity as a potential reason for failure. Symptoms of a titanium allergic reaction may include mucosal erythema, swelling of lips, purpuric patches on hard and soft palate, ulcers in the oral cavity, hyperplastic gingivitis, cheilitis, eczematous eruptions on face and …

J Mich Dent Assoc January 2026

The Journal of the Michigan Dental Association

Each month, the Journal of the Michigan Dental Association delivers news, information, and features about Michigan dentistry to our state's oral health community and the MDA's 6,200+ members. It remains the main publication reaching Michigan dentists and is available worldwide through ADA Commons. The January 2026 (Volume 108, No. 1) issue of the Journal is published in a print format to provide updates and insights for Michigan's oral health community and MDA members. Print editions occur every other month beginning with January.

This issue includes feature articles on Pediatric Dentistry and 2025 Life Membership recipients.

Regular monthly contributions include:

• Editorial …

Gut And Blood Diversity Microbiota Of Tilapia (Oreochromis Niloticus) Reared In Aquaponic Systems: A Scoping Review, Ang´Elica Adiaç˜Ao Jossefa, Leonildo Dos Anjo Viagem, Brunno Da Silva Cerozi Brunno Da Silva Cerozi, Sebastian Wilson Chenyambuga Sebastian Wilson Chenyambuga Chenyambuga

All Rsif Scholars' Publications

Tilapia is commonly integrated with vegetables in aquaponics systems, where complex microbial interactions may have important implications for food safety. This scoping review examines the current evidence on the microbiota diversity of tilapia reared in aquaponics systems, analyzes its potential influence on food safety, and highlight direction for future research. The review followed the Preferred Reporting Items for Systematic Re- views and Meta-Analyses Extension for Scoping Reviews (PRISMA-ScR) guidelines and included studies pub- lished between 2000 and 2025, retrieved from five scientific databases, including Google Scholar, Web of Science, Science Direct, PubMed, and Wiley Online Library. Only three studies met …

Gender Differences In The Association Between Adverse Childhood Experiences And Drug Use: Findings From A Community-Based Survey In China, Hongyun Fu, Elizabeth Monk-Turner, Xiushi Yang

Department of Pediatrics Faculty Publications

Background

While adverse childhood experiences (ACEs) are widely recognized risk factors for behavioral health problems, including drug use, prior research has largely been conducted in Western countries, focused primarily on males, and relied on convenience samples without comparison groups of nonusers. Limited work has examined the impact of ACEs on drug use in non-Western contexts. This study examines gender differences in the relationship between ACEs and drug use in China, using data from a population-based probability sample survey.

Methods:

Cross-sectional data were collected in 2019 from one city in Yunnan Province in Southwest China and one city in Guangdong Province …

Parenting Stress And Its Association With Parental Technoference: An Integrative Literature Review, Emily S. Machuca

Honors Undergraduate Theses

Introduction: Today, digital devices are a part of daily life, but can serve as a distraction that interrupts important relationships, a process referred to as technoference. In the context of parenting, device use during child interactions may reduce parental attentiveness and engagement, with potential implications for child development and behavior. Parenting stress may influence how and why parents engage with digital devices in the presence of their children. However, the association between parenting stress and parental technoference remains unclear in the current literature. This integrative literature review aimed to synthesize existing evidence examining the relationship between parenting stress and parental …

The Relationships Among Maternal Stress, Disordered Eating, Depressive Symptoms, And Infertility In Women Throughout The Postpartum Period, Christina Shoshilos

PCOM Psychology Dissertations

The perinatal period is a critical time of psychological, physiological, and social transition that can increase vulnerability to mental health challenges, particularly during the first year postpartum. This study examined the relationships among maternal stress, depressive symptoms, and disordered eating behaviors in postpartum women, with additional focus on differences by postpartum stage (0 to 6 months vs. 6 to 12 months) and infertility history. Participants (N = 248) were cisgender women who had given birth within the past 12 months and completed validated self-report measures of maternal stress, depressive symptoms, and disordered eating behaviors. A multiple regression analysis revealed …

Pediatricians’ Approach To Addressing Developmental, Behavioral, And Social-Emotional Concerns In Children, Jessica Baer

PCOM Psychology Dissertations

This study examined factors influencing pediatric primary care providers’ adherence to recommended guidelines for developmental, behavioral, and psychosocial screening, surveillance, and referral practices. Although early identification is emphasized in pediatric care, implementation remains inconsistent. A cross-sectional survey was administered to pediatric primary care providers in the United States with at least one year of independent practice experience. Variables examined included provider and practice demographics, training, confidence, caseload, and perceived barriers. Descriptive statistics and group comparisons were used to evaluate patterns in screening and referral practices. Results indicated variability in adherence across domains, with greater consistency in developmental and behavioral practices …

The Ecological Consequences Of Horizontal Transmission Of Symbionts, Bibek Singh Parajuli

Biology Dissertations

Most multicellular organisms depend on their microbial symbionts for various functions, such as digestion, nutrient supplementation, pesticide degradation, and defense. While many insects acquire their symbionts vertically from their parents, thousands of species of true bugs (Hemiptera) across different families acquire their microbial symbiont, Caballeronia, from the environment each generation. Acquiring symbionts from the environment (horizontal transmission) has various ecological consequences for the host. In this study, I used the bug-Caballeronia model 1) to understand whether the free-living symbionts benefit from association with multicellular hosts, 2) to evaluate whether host specialization on symbiont strains varies across taxonomic levels, …

Effects Of Fermented Soybean Products On The Human Gut Microbiome, Microbial Metabolism, And Host Physiology, Shannon Moncier

Biology Dissertations

Fermented soybean products (FSPs) contain soybean-derived substrates, fermentation-associated microorganisms, and bioactive compounds that may interact with the human gut microbiome and host physiology. However, despite the growing interest in FSPs, longitudinal human studies specifically evaluating traditional Korean-FSPs (K-FSPs), particularly among United States-based populations, remain limited. The objective of this work was to evaluate the effects of three K-FSPs, including Cheonggukjang, Gochujang, and Doenjang, on host physiological responses, gut microbial community structure, predicted microbial functional potential, and fecal butyrate responses in healthy adults. Three independent dietary intervention cohorts were conducted using FSP formulations produced either by traditional artisan methods (Product A) …

Neuromodulation Of Pain-Related Network Dynamics: Effects Of Electroconvulsive Stimulation On Local Field Potential Activity In A Formalin Pain Model, Diana A. Ibarra

Psychology Theses

Electroconvulsive therapy (ECT) is an established neuromodulatory intervention used to treat severe psychiatric conditions and is known to briefly affect memory function. Given that chronic pain affects millions and often leads to opioid dependence, ECT has been investigated to treat chronic pain. This study examined how electroconvulsive stimulation (ECS), the experimental equivalent of ECT used in animal models, alters or reduces pain-related brain neural activity associated with maladaptive pain-related memory circuit representations. The hypothesis is that ECS will disrupt or reduce neural activity associated with pain-related memory circuits, potentially revealing neural mechanisms that link pain and memory circuits through …