Digital Commons Network^™

Natural Products Induce Lysosomal Membrane Permeabilization As An Anticancer Strategy, Reginald Halaby

Department of Biology Faculty Scholarship and Creative Works

Cancer is a global health and economic issue. The majority of anticancer therapies become ineffective due to frequent genomic turnover and chemoresistance. Furthermore, chemotherapy and radiation are non-specific, killing all rapidly dividing cells including healthy cells. In this review, we examine the ability of some natural products to induce lysosomal-mediated cell death in neoplastic cells as a way to kill them more specifically than conventional therapies. This list is by no means exhaustive. We postulate mechanisms to explain lysosomal membrane permeabilization and its role in triggering cell death in cancer cells.

Two New Species Of Byrrhinus Motschulsky, 1858 (Coleoptera, Limnichidae, Limnichinae) From Negros, Philippines, Emmanuel D. Delocado, Hendrik Freitag

Biology Faculty Publications

Two new species of Limnichidae beetles, Byrrhinus negrosensis sp. nov. and Byrrhinus villarini sp. nov., are described from the Island of Negros in the Philippines. The adult specimens of the new species can be differentiated by patterns of body punctation, colour and orientation of elytral pubescence, posterolateral angle of pronotum, tarsomere length ratio and aedeagal form. Two clades, representing the two new species, were retrieved in the Maximum Likelihood gene tree using the 3’-end of the COI gene. Maximum genetic divergence within B. negrosensis sp. nov. and B. villarini sp. nov. were recorded to be 2.3% and 1.3%, respectively, while …

The Parthenon, November 10, 2021, Xena Bunton, Isabella Robinson, Madison Perdue, Abby Hanlon, Catherine Blankenship, Zach Hiser, Tyler Spence, Carter Truman, Tyler Kennett, Abby Ayes, Noah Hickman

The Parthenon

No abstract provided.

A Chickpea Genetic Variation Map Based On The Sequencing Of 3,366 Genomes, Rajeev K. Varshney, Manish Roorkiwal, Shuai Sun, Prasad Bajaj, Annapurna Chitikineni, Mahendar Thudi, Narendra P. Singh, Xiao Du, Hari D. Upadhyaya, Diego Jarquin

Department of Agronomy and Horticulture: Faculty Publications

Zero hunger and good health could be realized by 2030 through effective conservation, characterization and utilization of germplasm resources1 . So far, few chickpea (Cicerarietinum) germplasm accessions have been characterized at the genome sequence level2 . Here we present a detailed map of variation in 3,171 cultivated and 195 wild accessions to provide publicly available resources for chickpea genomics research and breeding. We constructed a chickpea pan-genome to describe genomic diversity across cultivated chickpea and its wild progenitor accessions. A divergence tree using genes present in around 80% of individuals in one species allowed us to estimate the divergence of …

Getting Out Of A Sticky Situation: Differential Escape Of Spotted Lanternfly From Two Commonly-Used Trapping Techniques, Jennifer L. Chandler

Sustainability Research & Practice Seminar Presentations

Professor Jen Chandler, Biology - Getting out of a Sticky Situation: Differential Escape of Spotted Lanternfly from Two Commonly-Used Trapping Techniques

Comparing Genetic Variation Among Latin American Immigrants: Implications For Forensic Casework In The Arizona- And Texas-México Borderlands, Briana T. New, Bridget F.B. Algee-Hewitt, M. Katherine Spradley, Lars Fehren-Schmitz, Cris C. Hughes, Bruce E. Anderson, Marek E. Jasinski, Joanna Arciszewska, Grażyna Zielińska, Maria Szargut, Sandra Cytacka, Andrzej Ossowski

Human Biology Open Access Pre-Prints

The humanitarian crisis on the United States-México border is a long standing and evolving crisis in which nearly 8,000 deaths have been reported in the last two decades. These deaths are largely distributed across the Arizona-México and Texas-México border regions where demographic trends for immigrants attempting to cross into the U.S. have shifted dramatically. The demographic change and volume of immigrants seeking shelter in the U.S. presents new challenges for the forensic practitioners entrusted with the identification of individuals who lose their lives during the final segment of their journey. Within this Border context, the present study investigates how genetic …

Panoramic Spatial Vision In The Bay Scallop Argopecten Irradians, Daniel R. Chappell, Tyler M. Horan, Daniel Isaac Speiser

Faculty Publications

We have a growing understanding of the light-sensing organs and light-influenced behaviours of animals with distributed visual systems, but we have yet to learn how these animals convert visual input into behavioural output. It has been suggested they consolidate visual information early in their sensory-motor pathways, resulting in them being able to detect visual cues (spatial resolution) without being able to locate them (spatial vision). To explore how an animal with dozens of eyes processes visual information, we analysed the responses of the bay scallop Argopecten irradians to both static and rotating visual stimuli. We found A. irradians distinguish between …

Machine Learning In Apache Spark Environment For Diagnosis Of Diabetes, Farshid Bagheri Saravi

Student Scholarship

Disease-related data and information collected by physicians, patients, and researchers seem insignificant at first glance. Still, the same unorganized data contain valuable information that is often hidden. The task of data mining techniques is to extract patterns to classify the data accurately. One of the various Data mining and its methods have been used often to diagnose various diseases. In this study, a machine learning (ML) technique based on distributed computing in the Apache Spark computing space is used to diagnose diabetics or hidden pattern of the illness to detect the disease using a large dataset in real-time. Implementation results …

College Of Business News, Georgia Southern University

College of Business: News & Publications

• Lt. Gen. Smith named Carter Chair of Leadership at Georgia Southern

Changing The Landscape Of Identity In Forensic Anthropology, Briana T. New, Bridget F.B. Algee-Hewitt

Human Biology Open Access Pre-Prints

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Explorations And Developments In Multifunctionality, 3d Printing, And Accelerated Aging For Thermoplastics And Thermosets, Zachary Brounstein

Nanoscience and Microsystems ETDs

If the world is to progress through the fourth industrial revolution, rapid advances in materials science must complement new technological feats in manufacturing, computation and device functionality, and a broader understanding of how materials behave as they age and degrade. To this effect, much effort has been directed towards polymeric materials to address and solve many problems in this new era. This includes developing polymer composites that incorporate fillers to imbue multifunctionality, fabricating novel formulations for additive manufacturing, and conducting aging studies to assess the performance of these materials over long time spans. Building and expanding on the latest research …

Mt10-Cvb3 Vaccine Virus Protects Against Cvb4 Infection By Inducing Cross-Reactive, Antigen-Specific Immune Responses, Ninaad Lasrado, Rajkumar Arumugam, Mahima T. Rasquinha, Meghna Sur, David Steffen, Jay Reddy

School of Veterinary and Biomedical Sciences: Faculty Publications

Group B coxsackieviruses (CVB) containing six serotypes, B1–B6, affect various organs, and multiple serotypes can induce similar diseases such as myocarditis and pancreatitis. Yet, no vaccines are currently available to prevent these infections. Translationally, the derivation of vaccines that offer protection against multiple serotypes is highly desired. In that direction, we recently reported the generation of an attenuated strain of CVB3, termed Mt10, which completely protects against both myocarditis and pancreatitis induced by the homologous wild-type CVB3 strain. Here, we report that the Mt10 vaccine can induce cross-protection against multiple CVB serotypes as demonstrated with CVB4. We note that the …

Dual Activities Of Acc Synthase: Novel Clues Regarding The Molecular Evolution Of Acs Genes, Chang Xu, Bowei Hao, Gongling Sun, Yuanyuan Mei, Lifang Sun, Yunmei Sun, Yibo Wang, Yongyan Zhang, Wei Zhang, Mengyuan Zhang, Yue Zhang, Dan Wang, Zihe Rao, Xin Li, Jeffery Shen, Ning Ning Wang

Life Sciences Faculty Research

Ethylene plays profound roles in plant development. The rate-limiting enzyme of ethylene biosynthesis is 1-aminocyclopropane-1-carboxylate (ACC) synthase (ACS), which is generally believed to be a single-activity enzyme evolving from aspartate aminotransferases. Here, we demonstrate that, in addition to catalyzing the conversion of S-adenosyl-methionine to the ethylene precursor ACC, genuine ACSs widely have Cβ-S lyase activity. Two N-terminal motifs, including a glutamine residue, are essential for conferring ACS activity to ACS-like proteins. Motif and activity analyses of ACS-like proteins from plants at different evolutionary stages suggest that the ACC-dependent pathway is uniquely developed in seed plants. A putative catalytic mechanism for …

Spectrum, Volume 47, Issue 8, Sacred Heart University

Newspapers (Obelisk & Spectrum)

Highlights include: New Provost at SHU -- News: Republicans Take Over Blue States -- Closing the Chapter on Facebook -- Perspectives: Fairfield Restaurant Week -- Sophomores Finding Housing Off -Campus -- SHU’s Elves Holiday Toy Drive -- “Songs of Sanctuary: A Concert Against Bullying -- Spring 2022 Registration: How Did it Go? -- Athlete Spotlight: Malik Grant Q&A

Distribution, Habitat Affinities, And Conservation Of Prairie Moonwort (Botrychium Campestre) On Its Northern Range Limit, Vladimir Kricsfalusy

Western North American Naturalist

Prairie moonwort (Botrychium campestre W.H. Wagner & D.R. Farrar) from the adder’s tongue family (Ophioglossaceae) is a rare plant species in North America with a NatureServe designation of G3N2 (Globally Vulnerable, Nationally Imperiled). The species reaches its northern distribution limit in Saskatchewan, Canada. The range of B. campestre is described here from literature, herbarium data, and field studies. Two newly discovered peripheral populations are reported, and their habitats are characterized in detail. One of the new occurrences was monitored over a multiyear period, and changes in population and vegetation cover are described. Possible threats to the newest occurrences are …

The Student Movement Volume 106 Issue 7: Honors Church Embraces The Many Voices Of Worship, Karenna Lee

The Student Movement v. 106 (2021-2022)

HUMANS

A Life in Missions: Interview with Nathan Gulzar, Interviewed by: Karenna Lee

ACA Student Interview: Terika Williams, Interviewed by: Grace No

ARTS & ENTERTAINMENT

Creative Spotlight: AU's Dance Studio, Interviewed by: Megan Napod

Jaguar, Hannah Cruse

Squid Game; A Netflix Phenomenon, Brendan Syto

What went wrong on the set of "Rust"?, Solana Campbell

NEWS

AUSA Senate: Improving Student Life, Jenae Rogers

Honors Church: Honoring the Many Voices of Worship, Andrew Pak

The Planning and Partnership behind the White Rabbit Night Market Program, Nathan Mathieu

IDEAS

How Discrimination and Neglect Led to Toxic Water in Benton Harbor, Lyle Goulbourne

Social …

Newsroom, Georgia Southern University

Newsroom (2006-2023)

• Lt. Gen. Smith named Carter Chair of Leadership at Georgia Southern

Shortcut Nitrogen Removal In Photo-Sequencing Batch Reactor, Experiments, Dynamic Model And Full-Scale Design, Sahand Iman Shayan

USF Tampa Graduate Theses and Dissertations

Nitrogen is one of the essential elements for life; however, inefficient use of nitrogen creates major environmental problems. Nitrogen-rich streams from urban areas, farms, and wastewater treatment plants (WWTPs) lead to surface and groundwater contamination, resulting in eutrophication, hypoxia, and notable environmental, public health and economic damage. Ammonia is a form of nitrogen that can be created during industrial or biological nitrogen fixation or decomposition of biomass. Anaerobic digesters (ADs) in WWTP generate biogas from collected sludge from primary and secondary clarifiers to achieve energy recovery in the plant. However, sidestream effluent from dewatering AD sludge contains high concentrations of …

Enhance Dopamine Autoreceptor Functioning During Blockade Of Dopamine Transporters, Rachel Laura Pace

Electronic Theses and Dissertations Archive

Dopamine autoreceptors (DARs) and dopamine transporters (DATs) influence dopamine transmission in the brain's mesolimbic pathway. Prior studies have focused on how activation of DARs influences trafficking of DATs, but how DATs influence DARs remains unclear. Male and female C57BL/6J mice received daily injections of either cocaine (DAT blocker) or saline for seven days then underwent stereotaxic surgery to obtain fixed potential amperometric recordings of DAR-mediated dopamine release. All mice received a mid-surgery injection of cocaine, and DAR-mediated dopamine release was assessed once more during maximal DAT blockade. The current study found that DAR functionality was increased during peak cocaine effects, …

Ecological Genomics Of Two Coastal Foundation Plant Species, Jeannie Mounger

USF Tampa Graduate Theses and Dissertations

I was born and raised in rural Florida on a tributary of the Withlacoochee River. “Withlacoochee” comes from a series of Muscogee Creek words that together mean “big little water,” possibly owing to the seasonal fluctuations in the breadth and flow of the river or to the chain of lakes that in part form it. The name contains within it an understanding of the capacity of land and water to undergo great shifts. It conjures images of mutable boundaries, of water covering and receding across the landscape over and over again. Many of my clearest memories from childhood are related …

Letitia Carson In Court: African American Women, Property, And Wages In The Pacific Northwest, Stephanie Marie Vallance

Dissertations and Theses

Letitia Carson arrived in Oregon from Missouri in 1845, accompanied by David Carson and their newborn child, a daughter named Martha. The Carsons settled in the Soap Creek Valley and took advantage of Oregon's Provisional Government's donation land claim program, living on 640 acres in the newly formed Benton County with Martha and a second child, a son named Adam, born a few years after arriving in Oregon. Within ten years, however, David would be dead and Letitia would be dispossessed of all property and belongings. A former slave, Letitia had little social standing in the new territory and no …

The Photophysical Studies Of Transition Metal Polyimines Encapsulated In Metal Organic Frameworks (Mof’S), Jacob M. Mayers

USF Tampa Graduate Theses and Dissertations

Light harvesting systems provide a platform that converts solar energy into other forms of energy. One of the most common examples of photon capturing and conversion into chemical energy is observed in photosynthetic organisms in both Eurkaroyic and Prokaryotic domains. Nature provides a model for successful light harvesting platforms which includes the compartmentalization of antenna complexes that contain separated donor and acceptor pairs that participate in efficient electron transfer processes. In order to mimic such systems, crystalline porous materials that exhibits regular cavities and pore dimensions provides an excellent starting place. Metal organic frameworks (MOFs) are a class of porous …

Can We Sustain Sustainability? A Critical Synthesis Of Pertinent Literature, Jay L. Brand, Sally J. Augustin

Faculty Publications

Architects and designers, along with their corporate clients, generally embrace the importance of environmental stewardship, saving the earth’s ecosystem, and sustainable design. However, research is needed to link sustainable design with relevant human behavior (e.g., in corporate offices and educational settings) to ensure its enduring legacy. Regarding changing people’s behavior, the majority of human experience results from unconscious processes, i.e., brain–environment interactions not available to awareness; thus, in general, people cannot articulate the nature of these associations. Using theoretical roots stemming from William James and running through ecological psychology (e.g., James J. Gibson to Roger Barker), Harry Heft has argued …

Research On Forage Quality: Progress And Priorities, J. A. Milne

IGC Proceedings (1977-2023)

A broad definition of forage quality is used and the purposes for which research on forage quality is undertaken currently are outlined. These range from research that provides simple measurements that describes the forage quality of a commercial product to research on forage quality to improve understanding of digestion processes. Much of the research in the last decade has related to improving predictive measurements. The different degrees of progress that have been made in the development and use of measurements to further our understanding of forage quality are described and related to their fitness of purpose. It is concluded that …

Forage Quality And The Environment, C. E. Lascano, A. Schmidt, R. Barahona

IGC Proceedings (1977-2023)

The influence of environmental factors on forage quality of temperate and tropical grasses has been reviewed by several authors, who summarized how light, temperature, drought and soil nutrients influence chemical composition, and digestibility of forages grown in contrasting areas of the world. The effects of season of the year on forage growth, grazing behavior and animal performance have also been the subject of numerous papers and reviews. However, there are few recent reviews that summarize how changes in climatic and edaphic factors influence forage quality of legumes with variable levels of condensed tannins (CT), which are important secondary compounds in …

The Effect Of Perennial Ryegrass Cultivar Lock Up Length And Nitrogen On Forage Quality For Silage, Joseph L. Jacobs, Frank R. Mckenzie, G. N. Ward

IGC Proceedings (1977-2023)

A study was undertaken to determine the effects of three perennial ryegrass (Lolium perenne L.) cultivars (Vedette, Impact and Nevis) with differing maturities, lock up length and nitrogen (N) application upon the dry matter (DM) yield and nutritive characteristics of pasture for silage. The addition of N at 50 kgN/ha significantly (P< 0.05) increased DM yield for all cultivars. Metabolisable energy (ME) (MJ/kgDM) of the ryegrass declined with time for all treatments, although by week 8 of lock up the ME content of Vedette was significantly (P< 0.05) lower than for other cultivars. When the DM yield and ME content of ryegrass at early ear emergence for each cultivar was compared, the harvestable metabolisable energy (MJ/ha) was highest for Nevis followed by Impact and Vedette. In conclusion, there is potential to use later maturing cultivars of ryegrass in south east Australia to allow for later harvesting of forage for silage, whilst maintaining ME and maximising DM yields. Furthermore the use of N fertiliser can also increase DM yields without impinging on pasture quality.

Screening Fresh Forages For Protein Degradation And Nutritive Value, Garry C. Waghorn, J. L. Burke

IGC Proceedings (1977-2023)

A method has been developed to prepare fresh forages for in sacco and in vitro incubation by freezing and mincing to achieve a particle size distribution of dry matter (DM) similar to in vivo conditions. The method is described and data presented to indicate losses of nitrogen (N) during in sacco digestion and net yield of ammonia from proteolysis in vitro for 22 fresh and conserved forages. Grasses, legumes and herbs were evaluated, with fractional degradation rates of forages ranging from 0.07h^-1 with tall fescue (Festuca arundinacea) to 0.24 h^-1 with chicory (Cichorium intybus). …

Evaluation Of Ten Tropical Grasses In The Northwest Region Of The State Of São Paulo-Brazil, C. V. Soares Filho, L. R. De A. Rodrigues

IGC Proceedings (1977-2023)

The experiment was carried out in the northwest region of the State of São Paulo-Brazil to evaluate ten grasses recently introduced in the region. The grasses studied were: Cynodon nlemfuensis cv. Tifton 68, C. dactylon cv. Tifton 78, Cynodon spp. cv. Tifton 85, C. dactylon cv. Florakirk, C. nlemfuensis cv. Florico, C. nlemfuensis cv. Florona, C. dactylon cv. Coastcross, Paspalum notatum cv. Tifton 9, Brachiaria brizantha cv. Marandu, Panicum maximum cv. Tanzânia 1. The following variables were determined: DM production, growth rate, IVDMD, CP, ADF and NDF.

The GRs varied from 81 to 102 and from 14 to 26 Kg …

Are Good Deeds Being Punished?: Independent Charity Patient Assistance Programs And The Anti-Kickback Statute, John C. Hood

Florida Law Review

Largely funded by the pharmaceutical industry, Independent Charity Patient Assistance Programs (PAPs) dispense billions of dollars of aid annually to help financially vulnerable patients afford their prescription drugs. Recently, these charitable entities and their drug company donors have faced mounting legal scrutiny for allegedly funneling illegal kickbacks to Medicare beneficiaries. This Note examines Independent Charity PAPs and the issues they raise under the Anti-Kickback Statute (AKS). It explores the uncertain legal environment in which Independent Charity PAPs operate and concludes that a new AKS regulatory safe harbor may be necessary to preserve the viability of the safety net assistance that …

Book Reviews, Florida Historical Society

Florida Historical Quarterly

No FURTHER RETREAT: THE FIGHT TO SAVE FLORIDA, by Raymond F. Dasmann, reviewed by Charlton W. Tebeau; ON PRESERVING TROPICAL FLORIDA, by John C. Gifford, reviewed by Polly Redford; ST. PETERSBURG AND ITS PEOPLE, by Walter Fuller, reviewed by Milton D. Jones; HISTORY OF SANTA ROSA COUNTY: A KING’S COUNTRY, by M. Luther King, reviewed by E. W. Carswell; JAMES BLAIR OF VIRGINIA, by Parke Rouse, Jr., reviewed by Jack P. Greene; THE LETTERBOOK OF ELIZA LUCAS PINCKNEY, 1739-1762, edited by Elise Pinckney, reviewed by Hugh Lefler; THE ANATOMY OF THE CONFEDERATE CONGRESS, by Thomas B. Alexander and Richard E. …