Digital Commons Network^™

Rationale And Design Of The Novel Uses Of Adaptive Designs To Guide Provider Engagement In Electronic Health Records (Nudge-Ehr) Pragmatic Adaptive Randomized Trial: A Trial Protocol, Julie C. Lauffenburger, Thomas Isaac, Lorenzo Trippa, Punam Keller, Ted Robertson, Robert J. Glynn, Thomas D. Sequist, Dae H. Kim, Constance P. Fontanet, Edward W.B. Castonguay, Nancy Haff, Renee A. Barlev, Mufaddal Mahesri, Chandrashekar Gopalakrishnan, Niteesh K. Choudhry

Dartmouth Scholarship

Background: The prescribing of high-risk medications to older adults remains extremely common and results in potentially avoidable health consequences. Efforts to reduce prescribing have had limited success, in part because they have been sub-optimally timed, poorly designed, or not provided actionable information. Electronic health record (EHR)-based tools are commonly used but have had limited application in facilitating deprescribing in older adults. The objective is to determine whether designing EHR tools using behavioral science principles reduces inappropriate prescribing and clinical outcomes in older adults. Methods: The Novel Uses of Designs to Guide provider Engagement in Electronic Health Records (NUDGE-EHR) project uses …

Arabidopsis Thaliana Zinc Accumulation In Leaf Trichomes Is Correlated With Zinc Concentration In Leaves, Felipe K. Ricachenevsky, Tracy Punshon, David E. Salt, Janette P. Fett, Mary Lou Guerinot

Dartmouth Scholarship

Zinc (Zn) is a key micronutrient for plants and animals, and understanding Zn homeostasis in plants can improve both agriculture and human health. While root Zn transporters in plant model species have been characterized in detail, comparatively little is known about shoot processes controlling Zn concentrations and spatial distribution. Previous work showed that Zn hyperaccumulator species such as Arabidopsis halleri accumulate Zn and other metals in leaf trichomes. To date there is no systematic study regarding Zn accumulation in the trichomes of the non-accumulating, genetic model species A. thaliana. Here, we used Synchrotron X-Ray Fluorescence mapping to show that Zn …

Elevated Temperature And Browning Increase Dietary Methylmercury, But Decrease Essential Fatty Acids At The Base Of Lake Food Webs, Pianpian Wu, Martin J. Kainz, Fernando Valdés, Siwen Zheng, Katharina Winter, Rui Wang, Brian Branfireun, Celia Y. Chen, Kevin Bishop

Dartmouth Scholarship

Climate change scenarios predict increases in temperature and organic matter supply from land to water, which affect trophic transfer of nutrients and contaminants in aquatic food webs. How essential nutrients, such as polyunsaturated fatty acids (PUFA), and potentially toxic contaminants, such as methylmercury (MeHg), at the base of aquatic food webs will be affected under climate change scenarios, remains unclear. The objective of this outdoor mesocosm study was to examine how increased water temperature and terrestrially-derived dissolved organic matter supply (tDOM; i.e., lake browning), and the interaction of both, will influence MeHg and PUFA in organisms at the base of …

Quantifying Planarian Behavior As An Introduction To Object Tracking And Signal Processing, Nicole C. Stowell, T. Goel, Vir Shetty , '22, Jocelyne Noveral, Eva-Maria S. Collins

Biology Faculty Works

Answers to mechanistic questions about biological phenomena require fluency in a variety of molecular biology techniques and physical concepts. Here, we present an interdisciplinary approach to introducing undergraduate students to an important problem in the areas of animal behavior and neuroscience—the neuronal control of animal behavior. In this lab module, students explore planarian behavior by quantitative image and data analysis with freely available software and low-cost resources. Planarians are ∼1–2-cm-long aquatic free-living flatworms famous for their regeneration abilities. They are inexpensive and easy to maintain, handle, and perturb, and their fairly large size allows for image acquisition with a webcam, …

Effects Of Nitrogen Management And Cultivar On Strawberry Production Under Disease Pressure, Kamille A. Garcia-Brucher

Master's Theses

Effects of nitrogen management and cultivar on strawberry production under disease pressure

Kamille Garcia-Brucher

California strawberry growers face increasing regulatory pressures to manage nitrogen (N) applications in their production system. Standard practice in the California strawberry industry is to apply a synthetic pre-plant controlled release fertilizer (CRF) to ensure the crop has sufficient N during winter establishment. Some research from the UC Cooperative Extension suggests this practice is not efficient at delivering N to the crop since most of the N is released from CRF before strawberry crop N uptake is significant. Another concern for California strawberry growers is loss …

Practical Wisdom As An Adaptive Algorithm For Leadership: Integrating Eastern And Western Perspectives To Navigate Complexity And Uncertainty, Mai P. Trinh, Elizabeth A. Castillo

Management Faculty Publications

In this paper, we integrate Eastern and Western perspectives of practical wisdom to answer the question, how can practical wisdom transfer across cultural boundaries in a world of increasing interconnection? We describe key properties of practical wisdom in early Western and Eastern schools of thoughts and explain how the concept of practical wisdom in ancient philosophy aligns with modern-day complex system science. We identify seven qualities of complex adaptive systems as a universal pattern that underlies both Eastern and Western perspectives. From these qualities, we develop an integrated conceptual framework of practical wisdom as factors both internal and external to …

Developing Design And Analysis Framework For Hybrid Mechanical-Digital Control Of Soft Robots: From Mechanics-Based Motion Sequencing To Physical Reservoir Computing, Priyanka B. Bhovad

All Dissertations

The recent advances in the field of soft robotics have made autonomous soft robots working in unstructured dynamic environments a close reality. These soft robots can potentially collaborate with humans without causing any harm, they can handle fragile objects safely, perform delicate surgeries inside body, etc. In our research we focus on origami based compliant mechanisms, that can be used as soft robotic skeleton. Origami mechanisms are inherently compliant, lightweight, compact, and possess unique mechanical properties such as– multi-stability, nonlinear dynamics, etc. Researchers have shown that multi-stable mechanisms have applications in motion-sequencing applications. Additionally, the nonlinear dynamic properties of origami …

A Critical Analysis Of The Discourse Of Culturally Responsive Curriculum Within South Carolina’S Secondary U.S. History And Constitution Standards, James L. Goude

All Dissertations

This research study explored the presence of implicit racial bias in South Carolina curriculum policy within its content standards for U.S. history and the Constitution. Curriculum policy discourse flows through the statewide public school system from the legislature, through district offices, and into classrooms. That discourse guides classroom teachers on what the state legislated as essential knowledge of U.S. history. Teachers make instructional choices based on state and district guidance documents that may affect the performance of Black students on South Carolina’s U.S. History and Constitution End-of-Course Exam (USHC-EOC). This study describes the educational policy discourse from macro-documents, meso- documents …

Impact Of Interventions On Student Performance Among Eighth Graders In Algebra 1, Tiffany Osborne

All Dissertations

Educational leaders and practitioners face challenges in South Carolina schools, but through improvement science processes (Bryk, Gomez, Grunow, & LeMahieu, 2015), they can collectively develop solutions which directly address those issues. In this Participatory Action Research (PAR) study, I partnered with participants in ongoing Plan-Do-Study-Act (PDSA) cycles (Bryk, et al., 2015) to improve student outcomes. I triangulated multiple data points and corroborated findings with students’ own perceptions to provide evidence that students can achieve in eighth grade Algebra 1 when given the opportunity to enroll in the course and when afforded appropriate ongoing academic interventions that foster conceptual understanding, self-efficacy, …

Towards Understanding Protein Immobilization Rules Through Site-Specific Covalent Immobilization Of T4 Lysozyme, Maxwell Hilbert

All Dissertations

Soluble enzymes have the unique ability to assist the conversion of complex substrates in fewer steps compared to conventional chemical synthesis; however, when immobilized to a surface, the insoluble enzyme's activity and stability can suffer in its new environment. To improve upon future immobilized enzyme efficacy, a fundamental understanding of the interactions across the enzyme, linker, and surface during covalent, site-specific immobilization that can be detrimental to its activity is required. More specifically, using a well-characterized and model enzyme, T4 lysozyme (T4L), 28 different cysteine attachment points' effects on site-specifically immobilized activity are examined. Different combinations of heterobifunctional amine-to-sulfhydryl crosslinkers …

Time-Lapse Observation Of Sarcomeric Addition In Hypertrophic Models Based On A Tissue Like Cardiomyocyte Culture, Ailin Wei

All Dissertations

Cardiac hypertrophy is the response of the heart to increased mechanical stress exerted on the heart. In a hypertrophic heart, the muscles elongate or/and thicken with cardiomyocytes growing sizes. It is assumed that cardiomyocytes elongate by adding sarcomeres in series; the cardiomyocytes thicken with the addition of sarcomeres in the parallel position.

In this study, a tissue-like culture model was achieved with step-like ICDs. Uniaxial static stretch has been applied to our unique culture model for studying mechanical-load-induced cardiac hypertrophy. Hypertrophic responses of these cardiomyocytes have been confirmed on transcriptional and translational levels in our tissue-like model. The two-photon excitation …

Ecological Outcomes Of Movement Behavior In Brown Pelicans From The South Atlantic Bight, Bradley Wilkinson

All Dissertations

Vagile organisms are expected to display movement behaviors that respond to a wide variety of both intrinsic and extrinsic factors. Identifying drivers of movement is fundamental to understanding the ecology of species, as well as implementing effective conservation measures. Technological advancements have allowed for the collection of fine-scale positional data at rapid temporal scales, which can be a powerful tool for assessing the movement behavior of tracked species and for understanding the potential fitness implications resulting from variations in animal space use. The goal of this dissertation was to identify important drivers of movement behavior and to describe the ecological …

Interventions To Increase Prospective Teacher Candidates' Praxis Ii Content Exam Scores, Takara Hart

All Dissertations

Teacher shortages are a pervasive issue in South Carolina’s public schools. Some prospective teacher candidates have shown obstacles in meeting the minimum required Praxis II Content exam score. The purpose of this qualitative phenomenological study was to explore and develop specific Praxis II Content exam interventions to improve scores for six prospective teacher candidates in South Carolina. All participants were trying to meet the licensure exam requirement for various alternative certification programs. Malcolm Knowles’ Andragogy Adult Learning Theory guided the study as a theoretical framework, and Lev Vygotsky’s Socio-Cultural Constructivism provided the conceptual frame. Descriptive coding and analysis, using Dedoose …

Enabling Dna-Informed Breeding For Disease Resistance In Peach, Wanfang Fu

All Dissertations

DNA-informed breeding is becoming conventional for Rosaceae crops. The advancement of genomic tools and their application in breeding has potential to accelerate the breeding cycle and increase breeding efficiency. The objective of this dissertation was to explore the application of whole genome markers to identify marker-trait associations and potential candidate genes associated with peach disease resistance traits and evaluate the feasibility of applying genomic prediction models in breeding for disease resistance in peach. Two economically important diseases, brown rot and bacterial spot, were explored.

Genome wide association studies (GWAS) were first applied in detecting regions in the peach genome associated …

El Leñador, December 2021, El Leñador Staff

El Leñador Newspaper

El Leñador is an English and Spanish newspaper produced by Humboldt State University students. Our staff cover and provide news to Latinx and other diverse communities on campus and in Humboldt County. We are committed to providing relevant news and expanding the representations and stories told about people of color and other marginalized groups. Our work helps create more social, political and cultural diversity in local media.

El Leñador es un periodico en español y inglés producido por estudiantes de la Universidad Estatal de Humboldt. Nuestro personal cubre y provee noticias a la comunidad Latinx y otras comunidades diversas en …

Comparing Organic And Conventional Yield Responses To Climate Variations, Joost Wilken Meyer

Graduate Theses and Dissertations

This thesis compares the responses of organic yields and conventional yields towards climate variations. To achieve this objective, weather variables such as growing season weather conditions (average temperature, precipitation, cloud cover, relative humidity, drought index), weather anomalies, the occurrence of severe or extreme droughts and excessive rainfalls, are combined with 23 data sets gathered from previous studies that compare organic and conventional yields from the same location and time periods. To narrow the scope, the thesis focuses on soybean, maize, and wheat production in Europe and North America. Study-level fixed-effects models are used to control for any time-invariant factors such …

Crispr Gene Editing Drivers, Barriers And Prospects: A Comparative Study Among Plant Scientists Globally, Adriaan Johannes De Lange

Graduate Theses and Dissertations

The introduction of CRISPR gene editing into food crops has potential to contribute to food security and sustainable food production globally. To date, most scientific studies have focused on consumer perception of CRISPR gene edited foods or the potential benefits and risks of the CRISPR technology and none have focused on the perceptions of plant scientists concerning CRISPR gene editing. This study aimed to explore the investments, functions, barriers, benefits for specific crops and beneficiaries of CRISPR gene editing according to plant scientists, by distributing an online survey in which 1,040 plant scientists active across six continents and in both …

Facing Injustice: How Face Recognition Technology May Increase The Incidence Of Misidentifications And Wrongful Convictions, Laura M. Moy

Georgetown Law Faculty Publications and Other Works

Does law enforcement use of face recognition technology paired with eyewitness identifications increase the incidence of wrongful convictions in U.S. criminal law? This Article explores this critical question and posits that the answer may be yes. Facial recognition is frequently used by law enforcement agencies to help generate investigative leads that are then presented to eyewitnesses for positive identification. But erroneous eyewitness accounts are the number one cause of wrongful convictions, and the use of face recognition to generate investigative leads may create the conditions for erroneous eyewitness identifications to take place. This is because face recognition technology is designed …

Relative Success Of Native Plants In Curb Cut Rain Gardens, Ana Singh, Rachel Warners, Jonathan Walt, Patrick Jonker, David P. Warners

Faculty and Professional Research

No abstract provided.

The Relationship Between Mindfulness, Social Anxiety Traits, And Emotions, Maria Jackeline Diaz

Theses and Dissertations

The relationship between mindfulness, social anxiety traits, and emotion processing is the first study of its kind to be looked over. In this study we will assess similarities and differences, plus how they work together to provide further research and understanding of these complexities when combined. Such research can be helpful in making us understand our emotions, as well as how our emotions can be perceived in social functioning and communication.

Assessment And Monitoring Of Deltaic Wetlands And Fluvial Systems: Refining And Validating A Multimetric Index Of Resaca Ecosystem Health, David Lecusay Jr.

Theses and Dissertations

Resacas are ancient distributary channels of the lower Rio Grande River historically serving as floodwater drainage pathways onto the Laguna Madre, Texas. Resacas provide numerous ecosystem services and critical habitat for many species. Mainly influenced by urbanization, integrating a multimetric index for assessing and monitoring resaca ecosystem health is required for adaptive management. The Resaca Health Index (RHI) integrates structural and functional components: (1) nonredundant metrics describing fish communities (Fish Community Index); (2) Trophic State Index derived from Secchi depth; (3) decay constant from riparian vegetation leaf litter decomposing in the water column; and (4) a riparian quality index based …

Total Synthesis Of E Stereoisomers Of Bilirubin Oxidation Products, Tess C. Ruiz

Theses and Dissertations

The purpose of the research was to synthesize the E stereoisomer of Bilirubin Oxidation Products that had not been synthesized through a total organic synthesis at the start of this project. There were numerous different procedures for the bromination of citraconic anhydride performed in an attempt to optimize yield and purity. A proposed scheme for the total synthesis of the E isomers was constantly updated and altered while the project was ongoing. The bioactivity of the compounds was to be tested if the project had been finished. This might have contributed to a greater understanding of their function and association …

Resiliency Of Utah's Road Network: A Logit-Based Approach, Max Evan Barnes

Theses and Dissertations

The Utah Department of Transportation (UDOT) manages and maintains a complex state-wide network of highways. Recent incidents such as the collapse of the I-35W bridge in Min- neapolis, Minnesota, and the I-85/Piedmont Road fire and subsequent bridge collapse in Atlanta, Georgia, have brought identification of transportation network vulnerabilities to the forefront of UDOT’s planning efforts. Traditional estimates of transportation network impacts have focused on increases to user travel time or the volume of affected traffic, but studies of these disasters have revealed that when facing a degraded transportation network, people adjust their trip making in terms of destination, mode, and …

Action Leveraging Evidence To Reduce Perinatal Mortality And Morbidity (Alert): Study Protocol For A Stepped-Wedge Cluster-Randomised Trial In Benin, Malawi, Tanzania And Uganda, Joseph Akuze, Kristi Sidney Annerstedt, Lenka Benova, Effie Chipeta, Jean-Paul Dossou, Mechthild M. Gross, Hussein Kidanto, Bruno Marchal, Helle Mölsted Alvesson, Andrea B. Pembe

Obstetrics and Gynaecology, East Africa

Background: Insufficient reductions in maternal and neonatal deaths and stillbirths in the past decade are a deterrence to achieving the Sustainable Development Goal 3. The majority of deaths occur during the intrapartum and immediate postnatal period. Overcoming the knowledge-do-gap to ensure implementation of known evidence-based interventions during this period has the potential to avert at least 2.5 million deaths in mothers and their offspring annually. This paper describes a study protocol for implementing and evaluating a multi-faceted health care system intervention to strengthen the implementation of evidence-based interventions and responsive care during this crucial period.

Methods: This is a cluster …

Using Fuzzy Clustering To Detect The Tumor Area In Stomach Medical Images, Ekhlas Falih Naser, Suhiar Mohammed Zeki

Baghdad Science Journal

Although the number of stomach tumor patients reduced obviously during last decades in western countries, but this illness is still one of the main causes of death in developing countries. The aim of this research is to detect the area of a tumor in a stomach images based on fuzzy clustering. The proposed methodology consists of three stages. The stomach images are divided into four quarters and then features elicited from each quarter in the first stage by utilizing seven moments invariant. Fuzzy C-Mean clustering (FCM) was employed in the second stage for each quarter to collect the features of …

The Model Of Development Of Precarious Practices During Covid-19 Pandemic: Society, Religion, And Individual, Оlena Honcharova, Valentyna Kuryliak

Occasional Papers on Religion in Eastern Europe

The article examines the phenomenon of precariousness and its development in the context of the COVID-19 pandemic. It is postulated that precariousness is a process of instability, which primarily affects the working class and destabilizes social relations at all levels, including the level of personal relationships. The human way of life has been shifted as a result of the epidemiological situation in the world caused by the COVID-19 infection. This process can be observed in the spheres of employment, medicine, religion, family, leisure activities, etc. Against the background of social turbulence, the processes of precariousness began to develop, which worsen …

Report And Recommendations To Address Race In Washington’S Juvenile Legal System: 2021 Report To The Washington Supreme Court, Task Force 2.0: Race And The Criminal Justice System

Fred T. Korematsu Center for Law and Equality

Report and Recommendations to Address Race in Washington’s Juvenile Legal System: 2021 Report to the Washington Supreme Court

Young And Dangerous: The Role Of Youth In Risk Assessment Instruments, Ingrid Yin

Michigan Law Review

States are increasingly adopting risk assessment instruments (RAIs) to help judges determine the appropriate type and length of punishment for an offender. Although this sentencing practice has been met with a wide variety of scholarly criticism, there has been virtually no discussion of how RAIs treat youth as a strong factor contributing to a high risk score. This silence is puzzling. Not only is youth undoubtedly the most powerful risk factor in most RAIs, but youth also holds a special place in the criminal justice system as a “mitigating factor of great weight.” This Comment presents the first in-depth critique …

Nmr Spectroscopy-Based Metabolomics Of Platelets To Analyze Brain Tumors, Shivanand Pudakalakatti, Alessandra Audia, Anirudh Mukhopadhyay, José S Enriquez, Dontrey Bourgeois, Nabihah Tayob, Niki M Zacharias, Steven W Millward, Daniel Carson, Mary C Farach-Carson, Frederick F Lang, Amy B Heimberger, Krishna P Bhat, Pratip K Bhattacharya

Faculty, Staff and Student Publications

"Tumor-educated platelets" have recently generated substantial interest for the diagnosis of cancer. We hypothesized that tumor educated platelets from patients with brain tumors will reflect altered metabolism compared to platelets from healthy volunteers. Here, in a pilot study, we have employed nuclear magnetic resonance (NMR) spectroscopy in platelets from brain tumor patients to demonstrate altered metabolism compared to the platelets obtained from healthy volunteers.

A Case For The Decriminalization Of Simple Possession Of Narcotics In Mississippi, Stroud Tolleson

Honors Theses

Through its incarceration of simple possession offenders, Mississippi is failing to acknowledge the severity of addiction and importance of mental health. In this paper, I will examine Mississippi’s history of opinion and policy on drug use. In order to gain a better understanding of addiction and Mississippi’s criminal justice system, I interview several individuals with experience in varying aspects of these issues. Mississippi has one of the highest rates of incarceration in the United States, with stringent laws regarding the possession of narcotics. Mississippi’s mental health resources have been deemed unconstitutionally deficient on more than one occasion, and addicts are …