Digital Commons Network^™

(R1504) Second-Order Modified Nonstandard Runge-Kutta And Theta Methods For One-Dimensional Autonomous Differential Equations, Madhu Gupta, John M. Slezak, Fawaz K. Alalhareth, Souvik Roy, Hristo V. Kojouharov

Applications and Applied Mathematics: An International Journal (AAM)

Nonstandard finite difference methods (NSFD) are used in physical sciences to approximate solutions of ordinary differential equations whose analytical solution cannot be computed. Traditional NSFD methods are elementary stable but usually only have first order accuracy. In this paper, we introduce two new classes of numerical methods that are of second order accuracy and elementary stable. The methods are modified versions of the nonstandard two-stage explicit Runge-Kutta methods and the nonstandard one-stage theta methods with a specific form of the nonstandard denominator function. Theoretical analysis of the stability and accuracy of both modified NSFD methods is presented. Numerical simulations that …

(R1458) A New Finite Difference Scheme For High-Dimensional Heat Equation, Jafar Biazar, Roxana Asayesh

Applications and Applied Mathematics: An International Journal (AAM)

In this research‎, ‎a new second-order finite difference scheme is proposed to solve two and three- dimensional heat equation‎. Finite difference equations are determined via a discretization approach in which spatial second order partial derivatives in x and y directions are approximated simultaneously‎ while in the classic method, each spatial partial derivative is replaced by a central finite difference approximation, separately. By this new discretization scheme and also using the forward difference to the first-order time derivative, a finite difference equation is obtained for the parabolic equation. This approach is explicit and similar to other explicit approaches, an interval for …

A Common Redpoll Northern Winter Population In An Irruption Year, Michael R. North

North American Bird Bander

No abstract provided.

Evidence Of Western Corn Rootworm (Diabrotica Virgifera Virgifera Leconte) Field-Evolved Resistance To Cry3bb1 + Cry34/35ab1 Maize In Nebraska, Jordan Reinders, Emily E. Reinders, Emily Robinson, Brian W. French, Lance J. Meinke

Department of Entomology: Faculty Publications

BACKGROUND: Western corn rootworm (WCR; Diabrotica virgifera virgifera) field-evolved resistance to transgenic maize expressing the Cry3Bb1 protein derived from Bacillus thuringiensis (Bt) has been confirmed across the United States Corn Belt. Although use of pyramided hybrids expressing Cry3Bb1 + Cry34/35Ab1 has increased in recent years to mitigate existing WCR Bt resistance, susceptibility of Nebraska WCR populations to this rootworm–Bt pyramid has not been assessed. Plant-based bioassays were used to characterize the susceptibility of WCR populations to Cry3Bb1 and Cry3Bb1 + Cry34/35Ab1 maize. Populations were collected from areas of northeastern Nebraska with a history of planting Bt maize that expressed Cry3Bb1 …

Characteristics Of Substance Addicted Mothers That Predict Graduation From The Family Treatment Court, Katherine Barnett

Doctorate of Nursing Science Dissertations

In the United States, substance addiction is a major contributing factor to incarceration of mothers and separation of children from their families. Five hundred Family Treatment Courts (FTC) operate across the country to combat the growing problem of women addicted to drugs. The FTC model provides mothers with substance addiction treatment, intensive judicial monitoring, repeated drug testing, counseling, incentives or sanctions, and case management with the goal of reaching long term sobriety and reunification with their children. Understanding characteristics that may influence graduation from the Family Treatment Court will provide valuable information on developing interventions to support participants’ success and …

The Medium-Term Impacts Of Integrated Crop–Livestock Systems On Crop Yield And Economic Performance, Teerath Singh Rai, Thandiwe Nleya, Sandeep Kumar, Peter Saxton, Tong Wang, Yubing Fan

Agronomy, Horticulture and Plant Science Faculty Publications

Integrated crop–livestock (ICL) systems are diverse production systems that can improve resource utilization through spatially or temporally rotating land among crop, livestock, and pasture uses. However, research on whether the enhanced resource utilization translates to greater crop productivity is still warranted. A field experiment was initiated at South Dakota State University in 2016 to determine the impacts of integrating cover crops and livestock grazing into a crop rotation of oat (Avena sativa L.)–maize (Zea mays L.)–soybean [Glycine max (L.) Merr.]. The objectives were to (a) determine the medium-term (4–6 yr) impacts of cover crops and livestock grazing …

Carbon Fiber Electrodes For Intracellular Recording And Stimulation, Yu Huan, Jeffrey P. Gill, Hillel J. Chiel

Faculty Scholarship

Objective. To understand neural circuit dynamics, it is critical to manipulate and record many individual neurons. Traditional recording methods, such as glass microelectrodes, can only control a small number of neurons. More recently, devices with high electrode density have been developed, but few of them can be used for intracellular recording or stimulation in intact nervous systems. Carbon fiber electrodes (CFEs) are 8 µm-diameter electrodes that can be assembled into dense arrays (pitches 80 µm). They have good signal-to-noise ratios (SNRs) and provide stable extracellular recordings both acutely and chronically in neural tissue in vivo (e.g. rat motor cortex). The …

Sociocultural And Psychological Acculturation Strategies Of South African International Students In A Flemish University In Belgium: A Photovoice Study

Journal of Comparative & International Higher Education

No abstract provided.

Plant Disease Detection Through Convolutional Neural Networks: A Survey Of Existing Literature, Best Practices, And Implementation, Kevin Label

Master's Theses

In the United States alone, common diseases spread among plants account for billions of dollars lost in crop yield each year. This issue is exacerbated in countries with less infrastructure to defend against crop epidemics, and can lead to famine and forced migration. Farmers can seek the help of plant pathology experts to defend against diseases and detect crop irregularities early on. However, access to experts can be difficult, and even those trained in the field may miss symptoms before it is too late. To assist in early disease detection, a number of papers have been released on the potential …

Ftc Orders Destruction Of Algorithms Created From Unlawfully Acquired Data, Randi W. Singer, Michael Goodyear

Articles & Chapters

No abstract provided.

It's Intense: A Mixed Methods Study Of Student Stress In Pta Education, Gina Tarud, Beverly A. Labosky, Laura Cruz, Nicole Paranich, Brian Thomas

Health Professions Education

Purpose. This study was implemented to measure the self-reported factors contributing to student stress and anxiety levels and the strategies employed to navigate these stressors.

Methods. This study utilized a mixed method design for collecting and analyzing both quantitative and qualitative data to identify the trends and details of the complex learning environment of the Physical Therapist Assistant (PTA) students. Current enrolled students within a Physical Therapist Assistant program were invited to participate in this study. A survey was created to gather the data using Qualtrics and a link was distributed via their university email.

Results. This study explored the …

Exploring Teaching Librarians' Beliefs About Undergraduate Student Learning, Ashlynn Kogut

Communications in Information Literacy

Whether formally articulated or tacitly held, all librarians have beliefs about how undergraduate students learn. Framing learning beliefs as a component of a teaching philosophy, this study explored how librarians described how undergraduate students learned best. Thirteen librarians from three doctoral universities in Texas were interviewed. Teaching librarians in this study believed that students learn in different ways; that students need to interact with others, act, and reflect in order to learn; and that students learn when certain conditions are met. The learning beliefs identified align with learning theories and the science of learning, but the threshold concepts theory underlying …

Micro-Computed Tomographic Analysis Of The Shaping Ability Of Xp-Endo Shaper In Oval-Shaped Distal Root Canals Of Mandibular Molars, Ane Poly, Wei-Ju Louis Tseng, Fernando Marques, Frank Carsten Setzer, Bekir Karabucak

Center for Translational Medicine Faculty Papers

Objective: To compare the shaping ability of the XP-endo Shaper (XPS) system to the ProTaper Next (PTN) system in oval-shaped distal root canals.

Methods: From 12 mandibular molars, distal roots with moderately curved single oval canals were randomly assorted to be instrumented with XPS (experimental group) or PTN (control group) and then scanned using micro-computed tomography [Scan 1]. The root canals of the XPS samples were prepared following the manufacturer's instructions using 15 insertions (XPS15) and rescanned [Scan 2]. An additional 10 insertions to the working length were applied, totalling 25 insertions (XPS25), and the roots were rescanned again [Scan …

Exploration Of Dark Chemical Genomics Space Via Portal Learning: Applied To Targeting The Undruggable Genome And Covid-19 Anti-Infective Polypharmacology, Tian Cai, Li Xie, Muge Chen, Yang Liu, Di He, Shuo Zhang, Cameron Mura, Philip Boume, Lei Xie

Publications and Research

Advances in biomedicine are largely fueled by exploring uncharted territories of human biology. Machine learning can both enable and accelerate discovery, but faces a fundamental hurdle when applied to unseen data with distributions that differ from previously observed ones—a common dilemma in scientific inquiry. We have developed a new deep learning framework, called Portal Learning , to explore dark chemical and biological space. Three key, novel components of our approach include: (i) end-to-end, step-wise transfer learning, in recognition of biology’s sequence-structure-function paradigm, (ii) out-of-cluster meta-learning, and (iii) stress model selection. Portal Learning provides a practical solution to the out-of-distribution (OOD) …

Increasing High School Students’ Awareness Of The Effects Of Gender Stereotypes, Kelly Y. Shepherd

Capstone Projects and Master's Theses

Gender stereotypes can prevent many adolescents from exploring aspects of their identity. One reason being, gender stereotypes are reinforced in media and society on a daily basis, constantly reaffirming the beliefs of what a male and female should act and look like. These beliefs may cause an adolescent to make choices about their identity without thinking or questioning, which is known as identity foreclosure. As a result, adolescents may limit themselves academically or socially which might restrict future career paths and job opportunities. My capstone project focused on teaching adolescent Girl Scouts of California Central Coast how to identify, question, …

Out Of A Darkness: A Collection Of Ramblings, Short Stories, And Poetry, Valerie Anthony

Capstone Projects and Master's Theses

A Collection of Poetry, Short Stories and Ramblings

Modeling Recurrence In Idiopathic Subglottic Stenosis With Mobile Peak Expiratory Flow, Kyle Kimura, Liping Du, Lynn D Berry, Li-Ching Huang, Sheau-Chiann Chen, David O Francis, Alexander Gelbard

Faculty, Staff and Student Publications

OBJECTIVES/HYPOTHESIS: We sought to establish normative peak expiratory flow (PEF) data for patients with idiopathic subglottic stenosis (iSGS), evaluate whether immediate changes in PEF after a procedure predict long-term treatment response, and test if a decline in longitudinal PEF is associated with disease recurrence.

STUDY DESIGN: International, prospective, 3-year multicenter cohort study of 810 patients with untreated, newly diagnosed, or previously treated iSGS.

METHODS: iSGS patients consented and enrolled in the North American Airway Collaborative (NoAAC) iSGS

RESULTS: Within the NoAAC iSGS1000 cohort, 810 patients participated in a 3-year, prospective study comparing surgical treatment efficacy and 385 had appropriate PEF …

Enzyme Kinetics, Molecular Docking, And In Silico Characterization Of Canary Seed (Phalaris Canariensis L.) Peptides With Ace And Pancreatic Lipase Inhibitory Activity, Uriel Urbizo-Reyes, Andrea M. Liceaga, Lavanya Reddivari, Kee-Hong Kim, Joseph M. Anderson

Department of Food Science Faculty Publications

The bioactivity of canary seed peptides (CSP) towards metabolism-regulating enzymes was evaluated. Peptides with angiotensin-converting enzyme (ACE), dipeptidyl peptidase IV (DPP-IV), and pancreatic lipase activity remained stable (p < 0.05) to simulated gastrointestinal digestion (SGD). CSP-SGD were transported efficiently (>10%) through the Caco-2 monolayer, indicating absorption through the intestinal epithelium. Lineweaver-Burk plots demonstrated that CSP-SGD act as mixed-type inhibitors for DPP-IV and α-glucosidase. Furthermore, CSP-SGD were potent as antihypertensive and antiobesity agents. Molecular docking and in silico analyses were targeted to understand CSP-SGD interactions with ACE and pancreatic lipase. ACE-inhibitory peptides (LHPQ, QTPHQ, KPVPR, and ELHPQ) acted as non-competitive inhibitors by destabilization of the transition state and Zn(II) coordination in …

Enhanced Drought Resistance Of Vegetation Growth In Cities Due To Urban Heat, Co2 Domes And O3 Troughs, Peng Fu, Leiqiu Hu, Elizabeth A. Ainsworth, Xiaonan Tai, Soe W. Myint, Wenfeng Zhan, Bethany J. Blakely, Carl J. Bernacchi

United States Department of Agriculture-Agricultural Research Service / University of Nebraska-Lincoln: Faculty Publications

Sustained increase in atmospheric CO2 is strongly coupled with rising temperature and persistent droughts. While elevated CO2 promotes photosynthesis and growth of vegetation, drier and warmer climate can potentially negate this benefit, complicating the prediction of future terrestrial carbon dynamics. Manipulative studies such as free air CO2 enrichment (FACE) experiments have been useful for studying the joint effect of global change factors on vegetation growth; however, their results do not easily transfer to natural ecosystems partly due to their short-duration nature and limited consideration of climatic gradients and potential confounding factors, such as O3. Urban environments serve as a useful …

Photosynthesis, Yield, Energy Balance, And Water-Use Of Intercropped Maize And Soybean, Elena A. Pelech, Brendan C.S. Alexander, Carl J. Bernacchi

United States Department of Agriculture-Agricultural Research Service / University of Nebraska-Lincoln: Faculty Publications

By 2050, the U.S. Corn Belt will likely face a 23% increase in leaf-to-air vapor pressure deficit (VPDL), the driving force of evapotranspiration (ET), which may restrict maize yield improvements for rainfed agroecosystems. Alternative cropping systems, such as maize and legume intercrops, have previously demonstrated yield and resource-use advantages over monocultures. In this study, the residual energy balance approach was used to gain insights into how an additive simultaneous maize and soybean intercrop system regulates ET and water-use efficiency (WUE) compared to standard maize and soybean monoculture systems of the U.S. Corn Belt. Experimental field plots were rain-fed and arranged …

Pan-Cancer Evaluation Of Gene Expression And Somatic Alteration Data For Cancer Prognosis Prediction, Xingyu Zheng, Christopher I. Amos, H. Robert Frost

Dartmouth Scholarship

Background: Over the past decades, approaches for diagnosing and treating cancer have seen significant improvement. However, the variability of patient and tumor characteristics has limited progress on methods for prognosis prediction. The development of high-throughput omics technologies now provides multiple approaches for characterizing tumors. Although a large number of published studies have focused on integration of multi-omics data and use of pathway-level models for cancer prognosis prediction, there still exists a gap of knowledge regarding the prognostic landscape across multi-omics data for multiple cancer types using both gene-level and pathway-level predictors. Methods: In this study, we systematically evaluated three often …

Measuring And Modeling Energy And Power Consumption In Living Microbial Cells With A Synthetic Atp Reporter, Yijie Deng, Douglas Raymond Beahm, Steven Ionov, Rahul Sarpeshkar

Dartmouth Scholarship

Background: Adenosine triphosphate (ATP) is the main energy carrier in living organisms, critical for metabolism and essential physiological processes. In humans, abnormal regulation of energy levels (ATP concentration) and power consumption (ATP consumption flux) in cells is associated with numerous diseases from cancer, to viral infection and immune dysfunction, while in microbes it influences their responses to drugs and other stresses. The measurement and modeling of ATP dynamics in cells is therefore a critical component in understanding fundamental physiology and its role in pathology. Despite the importance of ATP, our current understanding of energy dynamics and homeostasis in living cells …

Genomic Epidemiology Of Methicillin-Resistant And -Susceptible Staphylococcus Aureus From Bloodstream Infections, Joshua T. Smith, Elissa M. Eckhardt, Nicole B. Hansel, Tahmineh Rahmani Eliato, Isabella W. Martin, Cheryl P. Andam

Dartmouth Scholarship

Background: Bloodstream infections due to Staphylococcus aureus cause significant patient morbidity and mortality worldwide. Of major concern is the emergence and spread of methicillin-resistant S. aureus (MRSA) in bloodstream infections, which are associated with therapeutic failure and increased mortality. Methods: We generated high quality draft genomes from 323 S. aureus blood culture isolates from patients diagnosed with bloodstream infection at the Dartmouth-Hitchcock Medical Center, New Hampshire, USA in 2010–2018. Results: In silico detection of antimicrobial resistance genes revealed that 133/323 isolates (41.18%) carry horizontally acquired genes conferring resistance to at least three antimicrobial classes, with resistance determinants for aminoglycosides, beta-lactams …

Structural Analysis Of Cross Α-Helical Nanotubes Provides Insight Into The Designability Of Filamentous Peptide Nanomaterials, Fengbin Wang, Ordy Gnewou, Charles Modlin, Leticia C. Beltran, Chunfu Xu, Zhangli Su, Puneet Juneja, Gevorg Grigoryan, Edward H. Egelman, Vincent P. Conticello

Dartmouth Scholarship

The exquisite structure-function correlations observed in filamentous protein assemblies provide a paradigm for the design of synthetic peptide-based nanomaterials. However, the plasticity of quaternary structure in sequence-space and the lability of helical symmetry present significant challenges to the de novo design and structural analysis of such filaments. Here, we describe a rational approach to design self-assembling peptide nanotubes based on controlling lateral interactions between protofilaments having an unusual cross-α supramolecular architecture. Near-atomic resolution cryo-EM structural analysis of seven designed nanotubes provides insight into the designability of interfaces within these synthetic peptide assemblies and identifies a non-native structural interaction based on …

Coal Fly Ash Beneficiation For Reuse And Removal Of Boron, Cadmium, Chromium, Copper, And Selenium In Wastewater Treatment., Joseph E. Cahill

Electronic Theses and Dissertations

New regulations on coal-fired power plants make previously used wastewater treatment methods aimed to remove heavy metals obsolete. Therefore, there has been increased interest and investment into new technologies to treat coal-fired power plants effluent in the past few years. Traditionally, heavy metal removal technologies have been broken into three categories: physical, chemical or biological. However, with new regulations, each category by itself does not offer an ideal solution to removing acceptable concentrations of heavy metals found in the effluents at the coal-fired power plants. Here we report a novel proof-of-concept utilizing adsorption through ion-exchange/co-precipitation - chemical and physical - …

Scalable Synthesis Of Alumina Nanowires By Wet Chemical Method., Luis N Moreno

Electronic Theses and Dissertations

To satisfy an increasing demand for large-scale processes for producing alumina nanomaterials, a wet chemical method was evaluated. A potassium salt precursor was combined with aluminum to produce alumina – based nanowires. Compared with current methods such as thermal oxidation, sol-gel, and laser ablation, this method is highly scalable due to relatively low energy requirements and the ability to carry out the primary reaction under ambient conditions. The nanowire samples were evaluated using SEM, XRD, BET, and TEM to confirm morphology, phases present, and surface area. A porous nanowire structure was confirmed which has a BET surface area of 324.6 …

Update Of Multicellular Data Standard To Match Physicell "Compact" Output., Reid A Honeycutt

Electronic Theses and Dissertations

In the field of multicellular biology, it is currently very difficult for researchers to share digital data, due to a lack of standards for said data. Each laboratory will collect data from a particular project, which will describe only the features relevant to their research, and then present that data using written descriptions, charts, graphs, and images. This makes it difficult for the data produced by these studies be leveraged in other research efforts by scientists studying similar phenomena. An open-source, universal standard that attempts to meet this need is the MultiCellular Data Standard (MultiCellDS). MultiCellDS is described as a …

Design Of A 300cm2 Pemfc Stack With Force And Cfd Simulation To Optimize Flow Channels, Gasket Design, And Clamping Forces., Robert M. Ench

Electronic Theses and Dissertations

Proton exchange membrane fuel cells are important to the future of green energy as hydrogen can be made with green technologies and store energy for later use. Fuel cells can efficiently convert the hydrogen to electricity as needed. This study uses Solidworks simulation to make design improvements to the fuel cell before the prototype build stage of testing; this saves money and time by reducing the prototype builds needed.

In this study, a multi-channel serpentine design with two outlets versus a single outlet is evaluated using CFD to investigate pressure drop. Lower pressure drops are desirable as less energy input …

Solvent Engineering Of Molybdenum Disulfide Electrocatalyst For Hydrogen Evolution., Robert Carl Spalding

Electronic Theses and Dissertations

Energy is at an exponentially growing demand, and to keep up with these demands new technologies for renewable energy have received increased attention. Hydrogen plays a vital role in water electrolysis and fuel cells, as the hydrogen evolution reaction (HER) is the main step water splitting process. Most of the current electrocatalysts for HER are dominated by platinum and other precious metals due to their low over-potential and small Tafel slope, however, they are extremely costly. For this reason, cost-effective non-precious metal catalysts must be developed. Transition metal dichalcogenides, such as molybdenum disulfide (MoS2), are abundant and have recently shown …

Computational Modeling Of 3d-Printed Lactobacillus-Antibiotic Scaffolds For Bacterial Vaginosis., Veeresh P. Rai

Electronic Theses and Dissertations

The standard treatment for bacterial vaginosis (BV) is currently antibiotics, such as metronidazole, clindamycin, or tinidazole. These antibiotics are highly effective in getting rid of bacteria in the female reproductive tract (FRT); however, there are some bacteria that provide benefits to the FRT which also get expunged. While there are many strains of bacteria that play a beneficial role in the FRT, lactobacilli are among the most important. These bacteria are responsible for maintaining a healthy environment in the FRT via pH regulation by lactic acid metabolism. Antibiotics eliminate all bacteria from an environment, including lactobacilli, and as a result, …