Digital Commons Network^™

Hypothetical Ai Arbitrators: A Deficiency In Empathy And Intuitive Decision-Making, Cole Dorsey

Arbitration Law Review (2009 - Present)

No abstract provided.

Investigation Of Optical And Structural Properties Of Gesn Heterostructures, Oluwatobi Gabriel Olorunsola

Graduate Theses and Dissertations

Silicon (Si)-based optoelectronics have gained traction due to its primed versatility at developing light-based technologies. Si, however, features indirect bandgap characteristics and suffers relegated optical properties compared to its III-V counterparts. III-Vs have also been hybridized to Si platforms but the resulting technologies are expensive and incompatible with standard complementary-metal-oxide-semiconductor processes. Germanium (Ge), on the other hand, have been engineered to behave like direct bandgap material through tensile strain interventions but are well short of attaining extensive wavelength coverage. To create a competitive material that evades these challenges, transitional amounts of Sn can be incorporated into Ge matrix to form …

New Titanate Bioceramic Nanomaterials For Drug Delivery And Controlled Release, Seaab Imad Sahib

Graduate Theses and Dissertations

Nanomaterials have attracted much attention for biomedical applications due to their unique characteristics that are proven to be potential in cell sensing, drug delivery, biological membrane penetration, biocompatibility, and tissue adhesion. The outcomes of this dissertation presented in chapter III-V mainly discuss new approaches in drug delivery, cellular uptake improvement, and neuronal regeneration and protection using a well-optimized titanium-based nanomaterial. In particular, Chapter III summarizes the impact of two different versions of the titanate nanowires on ameliorating the delivery of the antimicrobial and anticancer drug in vitro. Those drugs were loaded on the surface of the fabricated nanowires and characterized …

Investigating Effects Of Microenvironmental Stress On Cell Metabolism Using Multiphoton Imaging, Lisa Rebello

Graduate Theses and Dissertations

Resistance to therapy in cancer is a major cause of poor prognosis in patients. Tumor hypoxia plays an active role in mediating treatment resistance and has been linked to metastases and metastatic potential in cancer. Our research focused on three objectives: i) To understand metabolic effects of chronic and intermittent hypoxia in murine breast cancer cells and its affiliation with metastatic potential ii) To identify the metabolic changes associated with radiation therapy in a panel of radiosensitive and radioresistant human head and neck cancer cells and iii) to monitor the changes in cell metabolism associated with gain of treatment resistance. …

Recombinant Production And Purification Of Green Fluorescent Protein (Gfp)-Fused Metal Binding Protein For Palladium Nanoparticle Synthesis, Shadrach Ibinola

Graduate Theses and Dissertations

In lieu of chemical and physical methods, biologically guided synthesis is increasingly used as a cost-effective medium for the fabrication of nanoparticles (NP). Recently, a palladium metal binding sequence Pd4 (TSNAVHPTLRHL) has been demonstrated to be instrumental in the production of palladium (Pd) nanoparticles. Although, by eliminating the additional cost of purification of the protein, the crude lysate of E. coli containing Pd specific protein has been proven to be a viable cost-effective means for the synthesis of Pd NP, studies have not be done to ascertain the comparative catalytic activity of nanoparticles synthesized from both clarified lysate and pure …

Compound-20 (Analog Of Curcumin) Prevents Acrolein-Induced Changes In Rats, Nelson Chijioke Nwaiwu

Theses (2016-Present)

Research has shown that acrolein, a known environmental pollutant, contributes to generation of free radicals leading to oxidative stress and physiological damage. Curcumin has been known to improve damages from oxidative stress due to its antioxidative and anti-inflammatory properties. It has been reported that to exert such an effect, a large dose of curcumin needs to be consumed on daily bases due to its high excretion through kidney. Here in collaboration with Dr. Chelliah from department of pharmaceutical, an analog form of curcumin (compound-20) was synthesized with promising more potent activity and absorption. The objective of this study was to …

V-Myb Avian Myel Oblast Viral Oncogene Homolog Like 1 (Mybl1) Knockdown And Its Role In A Triple Negative Breast Cancer, Nabras Mahmoud Abdulrahman

Theses (2016-Present)

Triple Negative Breast Cancer (TNBC) is defined as negative for three genes, estrogen receptor (ESR), progesterone receptor (PR) and Human epidermal growth factor receptor (HER2-neu) genes. Previous data show the V-Myb Avian Myel oblast Viral Oncogene Homolog Like 1 (MYBL1) gene is over-expressed in Triple negative breast cancer cell line (MDA-MB231). MYBL1 belongs to the MYB family of genes which are transcription factors and proto-oncogenes which are associated with cell cycle regulation, apoptosis, and differentiation, all of which are key events associated with cancers. It could be that MYBL1 contributes to these same processes in TNBC. Instead of studying MYBL1’s …

Aku Research 2021, Office Of Research And Graduate Studies

Office of Research and Graduate Studies

Content

- Foreword

- Research projects

- COVID-19 Research

- University updates

Susceptibility Of Shallow Groundwater Aquifers To Water Logging, Case Study Al Marashda Area, West Nile Valley, Qena, Egypt., Abd El-Fattah Elsheikh, Moustafa Barseem, Wajih Sherbeni

Mansoura Engineering Journal

Attempts were carried out to delineate the areas where the aquifer is vulnerable to water logging, head drop and pollution in the new and old reclamation areas as well. All of the hydrological, geophysical and soil factors were incorporated in the DRASTIC model. Parameters included are; depth to water, net recharge, aquifer media, water salinity, thicknesses and resistivity of successive geoelectrical layers soil media, topography and impact of the vadose zone. Saturated soil hydraulic conductivity varies from 4.43 X10-4 to 243 X10-4 m/sec. Groundwater is supplied from the gravel sand saturated sediments belonging to the Quaternary aquifer. The aquifer thickness …

Using Peptide Design To Engineer Polyelectrolyte Complex Biomaterials, Sara Tabandeh

Electronic Theses and Dissertations, 2020-2023

The self-assembly of oppositely charged polymers provides a versatile platform to design materials for diverse applications in biology and medicine. Electrostatically-driven phase separation of oppositely charged polymers in aqueous solution gives rise to the formation of a polymer-rich phase called a polyelectrolyte complex (PEC). PECs can be in the form of liquid droplets (complex coacervates) or amorphous solid precipitates. Unlike synthetic polymers, peptides are good candidates for developing tailor-made formulations and structure-property relationships due to their biocompatibility, precise control over sequences, and ability to program hydrogen bonding interactions. However, little is known about the effect of combining additional molecular interactions …

Leveraging Multimodal Learning Analytics To Understand How Humans Learn With Emerging Technologies, Elizabeth Cloude

Electronic Theses and Dissertations, 2020-2023

Major education and training challenges are plaguing the United States in preparing the next generation of the future workforce to meet the demands of the 21st Century. Several calls have been released to improve education programs to ensure learners are acquiring 21st century knowledge, skills, and abilities (KSAs). As we embark on the digital and automation ages of the 21st century, it is essential that we move away from traditional education programs that define and measure KSAs as static constructs (e.g., standardized assessments) with little consideration of the actual real-time deployment of these processes, missing critical information on the degree …

Study Of Mos2/High-K Interface And Implementation Of Mos2 Based Memristor For Neuromorphic Computing Applications, Durjoy Dev

Electronic Theses and Dissertations, 2020-2023

The scientific world is witnessing an unprecedented triumph of artificial neural network (ANN)- a computing system inspired by the biological neural network. With the enthralling quest for Internet of Everything (IoE), it is expected to have an unparalleled dominance of ANN in our day-to-day life. In recent times, memristor has come as an emerging candidate to realize ANN through emulating biological synapse and neuron behavior. Molybdenum disulfide (MoS2), one well-known two-dimensional (2D) transition metal dichalcogenides (TMDCs), has drawn interest for high speed, flexible, low power electronic devices since it has a tunable bandgap, reasonable carrier mobility, high Young's modulus, and …

Effects Of Abstinence-Based Sexual Education Compared To Evidence-Based Sexual Education In K-12 Schools, Lily Probst

The Eleanor Mann School of Nursing Undergraduate Honors Theses

Background: Historically, sexual education in the United States has been abstinence-based (ABSE), meaning that sexual education is centered around encouraging adolescents to abstain from sexual activity outside of wedlock. On the other hand, evidence-based sexual education (EBSE) includes abstinence in its curriculum but does not emphasize it, instead highlighting contraception and prevention strategies. Additionally, EBSE teaches adolescents about healthy relationships, attitudes towards sexuality, gender roles, and provides resources for sexual and reproductive health services. Supplying adolescents in K-12 schools with access to evidence-based sexual education may not only decrease teen pregnancy rates and incidence of sexually transmitted infections (STIs) but …

Bullying Experiences Among Families And Children With Autism Spectrum Disorder, Developmental Delay, Or Varying Ethnicities, Emma Humphrey

The Eleanor Mann School of Nursing Undergraduate Honors Theses

Bullying perpetration in schools is a significant problem within the United States that has shown to increase mental health issues and adverse outcomes in children. The purpose of this extended literature review is to evaluate the significance of bullying in children with developmental delay (autism spectrum disorder) and majority and minority ethnic groups. The review of literature analyzes implications of bullying within these vulnerable populations and the family factors associated with peer victimization. An analysis from twenty peer-reviewed chosen articles reflects heightened levels of bullying, mental health problems, and negative experiences of all researched populations. The increased amount of victimization …

King Mackerel (Scomberomorus Cavalla), Aubrey L. Anthony, Erin Keeley, David Kerstetter

All Scans: Kerstetter Fisheries and Avian Ecology 3D Scan Series

Neurocranium from [length] cm total length (TL) King Mackerel (Scomberomorus Cavalla), collected from Bravo Market on 11/16/2021 by Aubrey Anthony

An Exploration Of Effective Patient Education With An Emphasis On Concussion, Kayla M. Ruopp

Health, Human Performance and Recreation Undergraduate Honors Theses

Concussion is a prevalent healthcare issue in the US, with approximately 1.6-3.8 million sports and recreation-related concussions each year in all ages. A concussion can be defined as a traumatic brain injury caused by biomechanical forces. When an athlete sustains a concussion, a physiologic cascade of events occurs. The most common signs and symptoms of a concussion include: loss of balance, disorientation, headache and confusion. Concussion assessments are important in order to determine the presence of an impairment and there are a multitude of tests that clinicians can use in order to isolate each type of damage. Studies have shown …

The Relationship Between Gestational Diabetes And Stress: A Literature Review, Morgan Mcgrath

The Eleanor Mann School of Nursing Undergraduate Honors Theses

The incidence of gestational diabetes has been increasing over the past ten to twenty years. The purpose of this literature review is to gather existing literature to examine the relationship between gestational diabetes and oxidative stress. Twenty peer-reviewed articles from two databases were selected to be examined in this review. From these studies, it was found that oxidative stress was higher in women who were diagnosed with gestational diabetes, and supplementation with vitamins and minerals was beneficial in decreasing stress in these women. While these studies can help healthcare providers in educating women who have been diagnosed, more research should …

A Black-Footed Ferret And U.S. Law: Lessons Learned From The First Successful Clone Of A Native U.S. Endangered Species, Lauren Corey

North Carolina Journal of Law & Technology

No abstract provided.

Exploring Hydrologic Responses To Different Wildfire Spatial Patterns Through The Lens Of Computational Modeling, Luke M. Telfer

Boise State University Theses and Dissertations

Severe wildfire disturbances are becoming increasingly common in high-elevation forests of the western United States. These fires alter watershed hydrologic processes, threatening critical downstream water resources and aquatic ecosystems. However, watershed-scale postfire hydrologic responses and water balance changes are highly uncertain. While postfire effects on individual processes such as runoff, infiltration, evapotranspiration, and snow dynamics are relatively well known, the role of wildfire spatial patterns in governing hydrologic connectivity and interactions between water balance components is poorly understood due to challenges associated with measuring and comparing fires at large scales. This thesis aims to examine pattern-related postfire interactions between various …

Bioactivity Assessment Of Veratrum Californicum Alkaloids, Madison Dirks

Boise State University Theses and Dissertations

The native Idaho plant Veratrum californicum is known to contain steroidal alkaloids that function as inhibitors of hedgehog signaling, a pathway utilized for the growth and differentiation of cells as well as proper tissue development. Veratrum californicum was originally noticed when pregnant ewes consumed the plant and later gave birth to lambs with craniofacial mutations such as a cyclopean eyes. These malformations were caused by the plant’s steroidal alkaloid cyclopamine blocking the hedgehog signaling pathway. This same pathway is used by more than 20 types of cancer for multiplication of cells. Additional alkaloids have been found in Veratrum californicum, …

Mechanisms For Extracellular Matrix-Dependent Blood-Brain Barrier Dysfunction, Brian Adam Hoettels

Boise State University Theses and Dissertations

Dysfunction of the blood vessels that form the blood-brain barrier (BBB) is observed across various neurological disorders, including multiple sclerosis (MS). As barrier loss culminates in neuronal dysfunction and degeneration, a better understanding of the mechanisms underlying BBB dysfunction is needed.

Tight junctions are multiprotein complexes maintained by the endothelial cells lining the inner blood vessel wall to seal the intercellular space, and their disruption impairs BBB function. In my first chapter, I focus on how tight junctions are altered in CNS inflammatory demyelinating diseases (CNS-IDDs) like MS as BBB dysfunction is one of the earliest known stages in …

The Role Of Berberine, A Clinically Relevant Plant Derived Alkaloid, In T Cell-Mediated Immunosuppression, Alexandra Adorno Vita

Dissertations

The primary focus of this research was to determine the effect of berberine (BBR), a clinically relevant plant-derived alkaloid, on follicular T helper (Tfh) cell activation and differentiation, with implications for the generation of T cell-dependent humoral responses. This research revealed a novel function of BBR as a suppressor of Tfh cell proliferation in secondary lymphoid organs of BBR-treated mice that underwent immunization for arthritis induction in a collagen-induced arthritis (CIA) mouse model. Tfh cells provide signaling to B cells that is crucial for the generation of T cell-dependent humoral responses, such as affinity maturation, isotype class switching, and the …

Biochemical Ecology Of The Western Rattlesnakes: Venom Variation And Toxin Profiling Of The Crotalus Viridis/Oreganus/Scutulatus Complex, Cara Smith

Dissertations

Biochemical ecology examines the complex and dynamic relationships between organisms and their environment from a molecular perspective. This requires a holistic integration of ecology, evolution, and natural history with the fine-scale resolution of molecular biology and functional biochemistry. Venomous snakes have evolved a wide variety of extreme behavioral, physiological, and biochemical adaptations for prey capture, making them an ideal model for the study of predator trait evolution and protein adaptation. However, venoms must be understood from an ecological perspective in order to comprehend the evolutionary forces that shape the diversity of toxin families present in venoms. This holistic picture has …

Relationships Between Working Class, First Generation College Students And Their Parent(S)/Guardian(S): A Phenomenological Study On The Impacts Of Middle Class Socialization, Lindsay Ellen Mason

Dissertations

This constructionist phenomenological dissertation study explored stories from nine working class, first generation college students, specifically how middle class socialization on a four year university campus located in the Mountain West region of the United States impacts the relationships with their parent(s)/guardian(s). My primary research question was: How does attending college at a 4 year public university influence first generation, working class students’ relationships with the ir parent(s)/guardian(s)? My sub research questions were: What role does middle class socialization that occurs on a 4 year public university campus play in impacting this relationship? And what role does online learning/remote learning …

Biofortification As A Sustainable Solution For 'Hidden Hunger': Evaluating Its Impact On The Environment, Nutrition, Culture, And Ethics, Elysia Lewis

Honors Theses

Micronutrient malnutrition, also referred to as ‘hidden hunger’, negatively impacts the health of millions of people around the world. Because of this, several strategies to reduce malnutrition have been proposed, one of which is biofortification. The process of biofortification increases the nutrient content of plants during their vegetative life cycle. Research has been conducted that shows the ability of biofortification to increase micronutrient content in crops, so the next step is successful implementation and adoption by consumers. This paper reviews several publications that look at biofortification with respect to the environment, sustainability, human nutrition, culture, and ethics from a variety …

The Complexities Of Conscience: Reconciling Death Penalty L Aw With Capital Jurors’ Concerns, Meredith Martin Rountree, Mary R. Rose

Buffalo Law Review

Jurors exercise unique legal power when they are asked to decide whether to sentence someone to death. The Supreme Court emphasizes the central role of the jury’s moral judgment in making this sentencing decision, noting that it is the jurors who are best able to “express the conscience of the community on the ultimate question of life or death.” Manylower courts nevertheless narrow the range of admissible evidence at the mitigation phase of a capital trial, insisting on a standard of legal relevance that interferes with the jury’s ability to exercise the very moral judgment the Supreme Court has deemed …

Resource Gaps For Minority Entrepreneurs: A Study Of 3 Cities, Merissa Piazza, Iryna Lendel, Shneur Kushner, Jack Yochum

All Maxine Goodman Levin School of Urban Affairs Publications

This study aims to assess minority resource gaps in entrepreneurial ecosystems (EEs) in three cities across Ohio: Cleveland, Toledo, and Dayton. This report seeks to answer two main research questions: 1) What are the local factors of EEs that drive growth for minority entrepreneurs? And 2) Across three sites in Ohio, what are the gaps in access to different resources for minority entrepreneurs in the ecosystem? This report covers the first year of this project’s findings as the project team engaged with all three region’s ecosystems in 2021.

A Preliminary Investigation Into The Effects Of Lucilia Sericata (Meigen) Blow Fly Larval Feeding On Sharp Force Trauma (Sft) Wound Patterns In Decomposing Bones Of Sus Scrofa Domesticus, Erica L. Klafehn

Student Theses

An important aspect of forensic investigations involves the characterization and analysis of bone related trauma as this can provide valuable information regarding the manner and circumstances of death. Bone trauma can be classified into three main categories, which include Sharp Force Trauma (SFT), Blunt Force Trauma (BFT), and Gunshot Trauma. Previous experiments have explored SFT on flesh and bones, specifically made with knives or saws, coupled with various microscopic analytical methods. Minimal research has been done integrating both a forensic entomology and forensic anthropology approach, so it is imperative to understand previous literature detailing the behaviors of insects (blow flies), …

Tavr In Older Adults: Moving Toward A Comprehensive Geriatric Assessment And Away From Chronological Age: Jacc Family Series, Joy M Schmitz, Scott D Lane, Michael F Weaver, Ponnada A Narayana, Khader M Hasan, Delisa D Russell, Robert Suchting, Charles E Green

Faculty, Staff and Student Publications

Cocaine use continues to be a significant public health problem with limited treatment options and no approved pharmacotherapies. Cognitive-behavioral therapy (CBT) remains the mainstay treatment for preventing relapse, however, people with chronic cocaine use display cognitive impairments that are associated with poor response to CBT. Emerging evidence in animal and human studies suggests that the peroxisome proliferator-activated receptor-gamma (PPAR- γ) agonist, pioglitazone, improves white matter integrity that is essential for cognitive function. This project will determine whether adjunctive use of pioglitazone enhances the effect of CBT in preventing relapse during the early phase of recovery from cocaine use disorder. This …

The Relationship Between The Practice Of Martial Arts, Anxiety, Wellness, And Self-Efficacy, William K. Knight Jr

LSU New Orleans Theses and Dissertations

Although anxiety is a frequently researched topic, the growing numbers of diagnosed cases and the state of the present outcomes warrant the study of alternative approaches to address the causes and conditions of its prevalence, as well as possible adaptive strategies and tactics to improve outcomes for clients with anxiety. Counseling distinguishes itself in part due to its focus on well-being rather than mere alleviation of diagnosed symptoms. As such, it may be useful to measure the likelihood of some strategies and tactics associated with improved well-being in attempting to reduce symptoms of anxiety.

This study measured the practice of …