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2021-December-01-Meet Pamela AvendañO-Rubi, University Marketing And Communication, East Tennessee State University

ETSU News

Language is what ties everything and everyone together for Pamela Avendaño-Rubi, whose native language of Spanish has been the key to relationships and opportunities throughout her time at East Tennessee State University.

“I was born and raised in Mexico, and it wasn’t until maybe seven or eight years ago that I first learned English. That was the biggest thing ever,” said the senior pre-medical student. “So, I empathize with a lot of people for whom English is a second language, even the professors here who have English as a second language and they struggle to express themselves. I am able …

China's Food Pagodas: Looking Forward By Looking Back?, Yifei Li, Dale Jamieson

Journal of Food Law & Policy

In this Article we provide a close analysis of the Chinese Dietary Guidelines – the Food Pagoda. Our focus on the dietary guidelines is motivated by two main considerations. First, the guidelines represent the most comprehensive, nationwide, state sponsored effort to educate the people of China about food. Like citizens in most countries, Chinese people are presented with numerous, often competing, messages from scientists, food gurus and online influencers. The dietary guidelines are different in that they are backed by an entire suite of governmental resources for nationwide dissemination through hospitals, schools, public billboards, TV and radio ads, among others. …

Lasting Consequences Of Psyllid (Bactericera Cockerelli L.) Infestation On Tomato Defense, Gene Expression, And Growth, Kyle Harrison, Azucena Mendoza-Herrera, Julien Gad Levy, Cecilia Tamborindeguy

United States Department of Agriculture-Agricultural Research Service / University of Nebraska-Lincoln: Faculty Publications

Background: The tomato psyllid, Bactericera cockerelli Šulc (Hemiptera: Triozidae), is a pest of solanaceous crops such as tomato (Solanum lycopersicum L.) in the U.S. and vectors the disease-causing pathogen ‘Candidatus Liberibacter solanacearum’. Currently, the only effective strategies for controlling the diseases associated with this pathogen involve regular pesticide applications to manage psyllid population density. However, such practices are unsustainable and will eventually lead to widespread pesticide resistance in psyllids. Therefore, new control strategies must be developed to increase host-plant resistance to insect vectors. For example, expression of constitutive and inducible plant defenses can be improved through selection. Currently, it is …

Conolidine: A Novel Plant Extract For Chronic Pain, Amber N. Edinoff, Akash S. Patel, Mitchell W. Baker, Jesse Lawson, Christopher Wolcott, Elyse M. Cornett, Kambiz Sadegi, Adam M. Kaye, Alan David Kaye

School of Pharmacy Faculty Articles

Pain, the most common symptom reported among patients in the primary care setting, is complex to manage. Opioids are among the most potent analgesics agents for managing pain. Since the mid-1990s, the number of opioid prescriptions for the management of chronic non-cancer pain (CNCP) has increased by more than 400%, and this increased availability has significantly contributed to opioid diversion, overdose, tolerance, dependence, and addiction. Despite the questionable effectiveness of opioids in managing CNCP and their high rates of side effects, the absence of available alternative medications and their clinical limitations and slower onset of action has led to an …

Mif But Not Mif-2 Recruits Inflammatory Macrophages In An Experimental Polymicrobial Sepsis Model, Pathricia Veronica Tilstam, Wibke Schulte, Thomas Holowka, Bong-Sung Kim, Jessica Nouws, Maor Sauler, Marta Piecychna, Georgios Pantouris, Elias Lolis, Lin Leng, Jürgen Bernhagen, Günter Fingerle-Rowson, Richard Bucala

Pacific Faculty Work

Excessive inflammation drives the progression from sepsis to septic shock. Macrophage migration inhibitory factor (MIF) is of interest because MIF promoter polymorphisms predict mortality in different infections, and anti-MIF antibody improves survival in experimental models when administered 8 hours after infectious insult. The recent description of a second MIF superfamily member, D-dopachrome tautomerase (D-DT/MIF-2), prompted closer investigation of MIF-dependent responses. We subjected Mif^-/- and Mif-2^-/- mice to polymicrobial sepsis and observed a survival benefit with Mif but not Mif-2 deficiency. Survival was associated with reduced numbers of small peritoneal macrophages (SPMs) that, in contrast to large peritoneal macrophages …

Identification Of Disease-Linked Hyperactivating Mutations In Ube3a Through Large-Scale Functional Variant Analysis, Kellan P. Weston, Xiaoyi Gao, Jinghan Zhao, Kwang Soo Kim, Susan E. Maloney, Jill Gotoff, Sumit Parikh, Yen Chen Leu, Kuen Phon Wu, Marwan Shinawi, Joshua P. Steimel, Joseph S. Harrison, Jason J. Yi

College of the Pacific Faculty Articles

The mechanisms that underlie the extensive phenotypic diversity in genetic disorders are poorly understood. Here, we develop a large-scale assay to characterize the functional valence (gain or loss-of-function) of missense variants identified in UBE3A, the gene whose loss-of-function causes the neurodevelopmental disorder Angelman syndrome. We identify numerous gain-of-function variants including a hyperactivating Q588E mutation that strikingly increases UBE3A activity above wild-type UBE3A levels. Mice carrying the Q588E mutation exhibit aberrant early-life motor and communication deficits, and individuals possessing hyperactivating UBE3A variants exhibit affected phenotypes that are distinguishable from Angelman syndrome. Additional structure-function analysis reveals that Q588 forms a regulatory site …

A Global Agenda For Advancing Freshwater Biodiversity Research, Alain Maasri, Sonja C. Jähnig, Hendrik Freitag, 93 Co-Authors

Biology Faculty Publications

Global freshwater biodiversity is declining dramatically, and meeting the challenges of this crisis requires bold goals and the mobilisation of substantial resources. While the reasons are varied, investments in both research and conservation of freshwater biodiversity lag far behind those in the terrestrial and marine realms. Inspired by a global consultation, we identify 15 pressing priority needs, grouped into five research areas, in an effort to support informed stewardship of freshwater biodiversity. The proposed agenda aims to advance freshwater biodiversity research globally as a critical step in improving coordinated actions towards its sustainable management and conservation.

Translating Particulate Hexavalent Chomium-Induced Chromosome Instability, Loss Of Homologous Recombination Repair And Targeting Of Rad51 From Human Lung Fibroblasts To Human Bronchial Epithelial Cells., Idoia Meaza Isusi

Electronic Theses and Dissertations

Particulate hexavalent chromium [Cr(VI)] is a well-established human lung carcinogen. RAD51, a key protein in homologous recombination repair pathway, is inhibited after prolonged exposure to Cr(VI), leading to an increase in chromosome instability after prolonged exposures in human lung fibroblasts. chromosome instability is the proposed driver of Cr(VI) carcinogenesis. Since tumors from chromate workers develop from epithelial cells, we sought to translate these findings from human bronchial fibroblasts to human bronchial epithelial cells. We hypothesized Cr(VI) inhibits RAD51 after prolonged exposure leading to an increase in chromosome instability in human bronchial epithelial cells (BEP2D). We characterized the cytotoxicity and measured …

Part-Time., Anthony Mark Piedmonte

Electronic Theses and Dissertations

This thesis is a creative writing project in prose covering the first 70 pages of a novel manuscript titled Part-time. Part-time will center around a 25-year-old medical school dropout starting a new job at a neighborhood golf clubhouse and gym. This coming-of-age narrative follows Danny as he struggles with his sexual identity, student debt, and job outlook after returning to the privileged community he grew up in. This sample will introduce the major characters, the clubhouse setting, and the forming relationship dynamics. By the end of these pages, readers will gain insight into how the part-time employees of the Longwood …

"If Fear Wasn't Enough?!": African American Perceptions Of Policing After Breonna Taylor's Unprovoked Death., Moriah Antoinette Bellamy

Electronic Theses and Dissertations

This study investigates how African Americans perceive the racialization process in the criminal justice system following the death of Breonna Taylor. Focusing primarily on police-community relations in Louisville, KY, I find the Breonna Taylor case amplifies preconceived perceptions of race between civilian and non-civilian groups. To test the hypothesis that racialization in the criminal justice system has caused damaging effects on relations between African Americans and police, two virtual focus groups were designed to discuss participants’ experiences with law enforcement. My findings suggest that the racialization process in the criminal justice system negatively skewed African American civilians’ attitudes towards law …

A Soft Place To Land: The Importance Of Otherparenting At Pwis., Stephanie Renae Mayberry

Electronic Theses and Dissertations

This phenomenological study examined the importance of otherparenting performed by Black student affairs professionals at a predominantly White research-intensive institution in the mid-South. Otherparenting is a U.S. tradition that has West African roots in chattel slavery. Otherparenting is defined as those that assist blood mothers and fathers by sharing parenting responsibilities. Semi-structured interviews were conducted with seven participants across various functional units at the institution. The examination illustrated the commitment Black staff have in assisting Black students through the college campus rife with structural barriers, while also accounting for the level of taxation the commitment to otherparenting places on Black …

Social Disorganization And Violent Crime Across Nonmetropolitan Areas Of Kentucky., Daniel Ray Jude

Electronic Theses and Dissertations

This macro-level study examines the effects of social disorganization predictors on violent crime registered in nonmetropolitan areas of Kentucky from 2012 to 2016. The study intends to expand the line of research interested in verifying the applicability of the social disorganization theory (Shaw & McKay, 1942), including its new theoretical developments, to non-urban settings and plans to contribute to the literature willing to provide a better understanding of violent crime in rural areas. In response to Narag et al.’s (2009) call for a theoretical integration of environmental contaminants among the ecological factors that influence variations in crime, the study also …

A Remote Sensing Perspective: Mapping The Human Footprint In The Zambezi Region Of Namibia., Ariel E Weaver

Electronic Theses and Dissertations

The “human footprint” can be used as a general proxy to estimate human activities across the landscape. The human footprint in the Zambezi Region of Namibia is critically important for regional management of conservation efforts and land use planning. The land covers in the Zambezi Region are characteristically difficult to separate spectrally, due to a highly heterogeneous savanna landscape. Object Based Image Analysis (OBIA) and Random Forest (RF) methods are notable for their ability to improve classification accuracies of remotely sensed imagery. In this study, I investigate the extent of the human footprint in the Zambezi Region of Namibia, using …

Manifestations Of Students’ Voices: Examining Shifts, Academic Demands, And Identity Work In How Students Make Themselves Understood., Lauren Elizabeth Fletcher

Electronic Theses and Dissertations

Voice is a concept that is both highly sought after and elusive in education. While schools aim to foster students’ voices, many academic structures inadvertently conceal their voices and in turn their identities. Definitions of voice have been assumed, vague, or looked at as a writing trait, with little consideration of voices’ dynamic and mediated structures. Drawing on scholarship grounded in sociocultural theories and dialogism (e.g., Bakhtin, 1986; Engeström; 1987, Leont’ev, 1981; Rosenblatt, 1978; Vygotsky, 1978), I contribute a new, tangible definition of voice, in which voice is a dynamic happening, continually negotiated and constructed. This dissertation explores students’ voices, …

Visualizing Anhydrobiosis: Liquid-Liquid Phase Separation, Membraneless Organelles, And Cellular Reorganization., Clinton J. Belott

Electronic Theses and Dissertations

Water is an integral and necessary component of life. It is then, exceedingly remarkable that some species are capable of surviving virtually complete water loss for extended periods of time. Several decades of intense research into anhydrobiosis, or life without water, have given significant insights into the molecular mechanisms governing this phenomenon. Anhydrobiosis-related intrinsically disordered (ARID) proteins have been demonstrated to be critically important for desiccation tolerance in many anhydrobiotic species and exhibit a considerably wide range of protective properties that include membrane stabilization, reinforcing bioglass formation, and protein stabilization. This dissertation begins with cellular dielectrophoresis suggesting that two ARID …

Q-Griffithsin Interactions And Utility For The Prevention And Treatment Of Mucosal Infections., Henry Nabeta

Electronic Theses and Dissertations

Griffithsin (GRFT) is a carbohydrate binding agent (lectin) that was originally identified in the red alga Griffithsia sp. Q-Griffithsin (Q-GRFT) is an oxidation stable analog of GRFT. GRFT has demonstrated inhibitory activity against HIV-1, Coronaviruses, Hepatitis C, influenza and Ebola viruses. The broad-spectrum activity suggests the potential utility of this lectin in a wide range of viral infections. However, the lectin’s activity in mucosal infections has not been extensively studied. Using in vitro, ex vivo and in vivo assays, we have demonstrated that Q-GRFT maintains the ability to bind glycosylated ligands following incubation in murine, macaque and human rectal …

An Exploration Of Afrocentric Features At A Black Homeschool Collective., Tytianna Nikia Maria Wells

Electronic Theses and Dissertations

This dissertation explores the development and benefits of familial relationships as the primary feature of Afrocentricity at Black Scholars Academy (BSA), a Pre-Kindergarten (Pre-K) through 12th-grade Black homeschool collective in the United States. This qualitative study draws upon Afrocentricity as a theoretical framework to analyze and interpret data collected from classroom observations, individual interviews with current and former teachers and students, and textual artifacts between July and November 2019. Familial relationships—an African time orientation, a personalized learning plan, OurStory, and Rising Meeting—are present in BSA. Familial relationships helped students develop cultural pride, agency, self-determination, independence, liberation through education, and a …

Theoretical Investigation Of The Co-C Bond Activation In Methylcobalamin And Adenosylcobalamin-Dependent Systems: Mechanistic Insights., Arghya Pratim Ghosh

Electronic Theses and Dissertations

The vitamin B₁₂ derivates, otherwise known as cobalamin (Cbl), are ubiquitous organometallic cofactors. The biologically active forms of Cbl, such as methylcobalamin (MeCbl) and adenosylcobalamin (AdoCbl), act as cofactors in different physiological reactions for both prokaryotes and eukaryotes. A crucial aspect of the Cbl-mediated systems is the activation of the organometallic Co-C bond that plays a critical role in its catalytic activity. One of the most remarkable features of this Co-C bond is its unusual activation in AdoCbl-dependent enzymatic reactions, where a trillion-fold rate acceleration of the Co-C bond cleavage is observed inside the enzyme compared to the isolated …

Black Codes Re-Envisioned: The Dred Scott Majority Opinion As An Antiblack Performative Speech Act., Tiffany Dillard-Knox

Electronic Theses and Dissertations

This dissertation is a discursive analysis of the decision in the Dred Scott v Sandford, 1857 case written by Chief Justice Roger Taney. It begins with an overview of the literature on performative speech acts, focusing on the aspects of performatives that relate to Louis Miron and Jonathan Xavier Inda’s thesis that race is a performative speech act. Breaking from their use of race as the analytic, this analysis is situated within a black/nonblack paradigm. This provides a framework that focuses on the unique ways in which the discourse of the text enacts, accumulates and renders blackness fungible. The …

Collaborative Human-Machine Interfaces For Mobile Manipulators., Shamsudeen Olawale Abubakar

Electronic Theses and Dissertations

The use of mobile manipulators in service industries as both agents in physical Human Robot Interaction (pHRI) and for social interactions has been on the increase in recent times due to necessities like compensating for workforce shortages and enabling safer and more efficient operations amongst other reasons. Collaborative robots, or co-bots, are robots that are developed for use with human interaction through direct contact or close proximity in a shared space with the human users. The work presented in this dissertation focuses on the design, implementation and analysis of components for the next-generation collaborative human machine interfaces (CHMI) needed for …

Youth Mental Health Service Preferences And Utilization Patterns Among Latinx Caregivers, Alejandro L. Vázquez, María De La Caridad Alvarez, Cynthia M. Navarro Flores, José Manuel González Vera, Tyson S. Barrett, Melanie M. Domenech Rodríguez

Psychology Faculty Publications

Latinx caregivers underutilize traditional youth mental health services (MHS) relative to their White counterparts. Disparities may be explained by barriers preventing engagement in traditional MHS. A potential mismatch between available services and preferred culturally appropriate healing practices may also contribute to treatment disparities. The current study examined Latinx caregivers’ perceived need for and utilization of support services in relation to family characteristics, youth problem-type, and barriers to care. Findings were contextualized by assessing caregiver preferences for addressing youth psychopathology. The study consisted of 598 Latinx caregivers from across the United States. Descriptive statistics and binary logistic regression models were used …

Boxed In: Hinge Closing Performance Of Ornate Box Turtles (Terrapene Ornata), Gina L. Buelow

Graduate Theses/Dissertations

Turtles are perhaps best known for the bony shells that encase them, a unique morphological trait that provides protection against predators. Many taxa have even evolved the ability to enclose themselves using hinges that can be used to create a seal between the carapace and plastron. I measured the hinge closing force of Ornate Box Turtles (Terrapene ornata) to assess the performance of this unusual yet ecologically important trait. I sampled head-started turtles from Thomson Sand Prairie in the Upper Mississippi River National Wildlife and Fish Refuge and wild turtles collected in northern Oklahoma. To assess the effects of head-starting …

Effects Of "Lemongrass Factor" On Galleria Mellonella Hemocytes, Jennifer C. Rice

Graduate Theses/Dissertations

The use of conventional chemical insecticides to control agricultural pest has become problematic as they may have a negative impact towards human health and the environment, resulting in a need to research alternative methods to insect pest control. Plant derived substances like essential oils have been used for generations as toxicants, repellants, and anti-feedants to control agricultural pest. More research is needed to understand how insect immune systems react to essential oils and if cellular immune responses of phagocytosis, encapsulation, and nodulation can be inhibited by such. Subjecting Galleria mellonella to various concentrations of “lemongrass factor” lets the researcher/scientist know …

The Erasure Of Monosexism: An Exploration Of Identity Development In Bisexual Women, Emma M. Leonard

Graduate Theses/Dissertations

Research has shown that bisexual individuals experience poorer mental health outcomes, resulting in depression, anxiety, substance use, and suicidal ideation, than their gay or straight counterparts (Calzo, Antonucci, Mays, & Cochran, 2011; Ross, Dobinson, & Eady, 2010; Taylor, Power, & Smith, 2020). These poor mental health outcomes suggest bisexual individuals may be experiencing hardships these other groups are not. This qualitative study sought to gain an understanding of the lived experiences of bisexual women aged 18-25. The researcher sought to gain an understanding of self-identified resiliency factors by the women as it pertains to their sexual/affectional orientation. Detailed interviews were …

A Christian Response To Modern Extraterrestrialism, Chase Perry Cakmis

Masters Theses

Extraterrestrial beliefs (ET-ism) have become a cultural craze in contemporary times, infatuating many who encounter these ideas. ET-ism has influenced all forms of media, science, and even religion. With ET-ism permeating all facets of society, Christians need to know how to approach this craze and the ideas that sprout from it. Much research has been conducted on this subject both on the individual and scientific level, thrusting these beliefs from fringe views believed only by the paranoid into widely accepted ideas even within the scientific community. While Christian circles have discussed this subject in the past, it is becoming a …

Drawing On Imagination: Soul Care For Adolescents Through Art, Nanette Cross

Masters Theses

The most inescapable part of the human condition is aging. One of the most challenging periods of growth involves the transformation of a person from a child into an adult. Every human being descended from Adam and Eve, has had to pass through the crucible known as adolescence. While some seem to thrive during this period of life, others can have an extremely difficult and overwhelming experience. Inaccurate self-image, peer pressure, lack of acceptance, confusion, awkwardness, bullying, perceived lack of agency, high sensitivity, and high expectations are all stress factors that consistently plague this age group to the point of …

Questions With Purpose: Utilizing Technology To Maximize The Parent/Child Reflective Discourse, Earl Tubbs

Masters Theses

For a young child, parents are the “no one” and “everyone” that Saint Augustine spoke of. Providing a positive example through action is important but shaping their moral compass by reflecting on their life experiences is equally important. Stated succinctly, reflective discourse is an interactive conversation between parent and child where the parent guides one’s children through recent life experiences, viewed through a specific lens. By reviewing logic driven and emotional responses, the positive and negative consequences to their behavior, and the people involved, parents can aid their children as they shape their definition of right and wrong. By reviewing …

Lower Extremity Power And Movement Velocity In Competitive Older Athletes, Becca D. Jordre

Dissertations and Theses

Older adults are a rapidly growing population which house a subset of older athletes who regularly engage in sport competition. The physical health and risk factors of this competitive older athlete population have been largely overlooked by healthcare providers and researchers and are poorly understood. Older athletes exhibit distinctly different measures of physical performance which require unique thresholds to identify health-related risk factors. While lower extremity power and movement velocity have been identified as valuable measures of physical performance and fall risk in community-dwelling older adults this relationship has not been explored in competitive older athletes. One method for analyzing …

Mental Fatigue On Landing Performance, Madison Marie Gaffney

Dissertations and Theses

Mental fatigue has been shown to impair physical performance, especially for endurance-based sports. However, little research has been done regarding the impacts of mental fatigue on shorter maximal effort movements during a common sport related activity such as the depth jump. The purpose of this study was to investigate the effects of mental fatigue on short maximal performance efforts and predisposing biomechanical variables for non-contact ACL tears during depth-jumps in 18 Division I female soccer players. Each participant completed five depth jumps, followed by a 30-minute Stroop task to induce mental fatigue, and then completed five more depth jumps. Multiple …

Modulation Of Stress-Induced Behaviors Through Orexinergic Signaling In The Basolateral Amygdala, Jazmine D W Yaeger

Dissertations and Theses

Stress initiates behavioral disturbances, which are often seen as symptoms of psychiatric disorders, like post-traumatic stress disorder (PTSD), depression, and anxiety. While stress is involved in the formation of disordered states, only certain individuals are vulnerable to, and therefore experience, these outcomes. Further, females are more likely to be diagnosed with stress-induced psychiatric disorders. Elements within stress neurocircuitry offer insight into differential behavioral outcomes associated with stressful experiences; and the basolateral amygdala (BLA), where pro- and anti-stress signals are integrated, is likely an important mediator in phenotype development. The orexin system, too, while being strongly associated with sleep, motivation, and …