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Articles 162721 - 162750 of 819621

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Performance Of Millet Cultivars In Succession To Field Crop Of Beans In Southern Portion Of State Of Minas Gerais - Brazil, José C. Pinto, M. C. Maia, A. R. Evangelista, I. F. De Andrade, Joel Augusto Muniz, I. P. A. Dos Santos, E. R. P. Bomfim Dec 2021

Performance Of Millet Cultivars In Succession To Field Crop Of Beans In Southern Portion Of State Of Minas Gerais - Brazil, José C. Pinto, M. C. Maia, A. R. Evangelista, I. F. De Andrade, Joel Augusto Muniz, I. P. A. Dos Santos, E. R. P. Bomfim

IGC Proceedings (1977-2023)

This trial was carried out at the Department of Animal Science - Universidade Federal de Lavras (UFLA), from February to June, 1997. It was evaluated the performance of three millet [Pennisetum glaucum (L.) R. Br.] cultivars, as a second crop (Common, BN 2 and CMS 02) and four sowing dates (02/22, 03/14, 04/03 and 04/23). The three millet cultivars were sown after a cropping of beans (Phaseolus vulgaris L.) by the end of the rainy season, with no additional fertilization. It was used the randomized block design in a split-plot scheme, allocating the sowing dates on the main …


Abooks And The Aim Project, Magne V. Aarset, Leiv Kåre Johannesen, Michael Esplago Dec 2021

Abooks And The Aim Project, Magne V. Aarset, Leiv Kåre Johannesen, Michael Esplago

International Maritime Lecturers' Association (IMLA) 2021 Joint Conference With IMEC32, ICERS15 and INSLC21

During the last decades, learning has once again become a key topic. However, this time, not only for students and professors but also in political and economic contexts. One reason for this is that a high level of education and skills of nations, organizations, and individuals are considered both necessary and crucially competitive advantages in the present knowledge society and the globalized market. Therefore, obtaining a quality education is fundamental for all of us in today's competitive business world. In particular, adult learning within the maritime sector has been important for the success of this industry for ages. The question …


Host Range, Biology, And Species Specificity Of Seven-Segmented Influenza Viruses—A Comparative Review On Influenza C And D, Chithra Sreenivasan, Zizhang Sheng, Dan Wang, Feng Li Dec 2021

Host Range, Biology, And Species Specificity Of Seven-Segmented Influenza Viruses—A Comparative Review On Influenza C And D, Chithra Sreenivasan, Zizhang Sheng, Dan Wang, Feng Li

Maxwell H. Gluck Equine Research Center Faculty Publications

Other than genome structure, influenza C (ICV), and D (IDV) viruses with seven-segmented genomes are biologically different from the eight-segmented influenza A (IAV), and B (IBV) viruses concerning the presence of hemagglutinin–esterase fusion protein, which combines the function of hemagglutinin and neuraminidase responsible for receptor-binding, fusion, and receptor-destroying enzymatic activities, respectively. Whereas ICV with humans as primary hosts emerged nearly 74 years ago, IDV, a distant relative of ICV, was isolated in 2011, with bovines as the primary host. Despite its initial emergence in swine, IDV has turned out to be a transboundary bovine pathogen and a broader host range, …


Extracellular Vimentin As A Target Against Sars-Cov-2 Host Cell Invasion, Łukasz Suprewicz, Maxx Swoger, Sarthak Gupta, Ewelina Piktel, Fitzroy J. Byfield, Daniel V. Iwamoto, Danielle Germann, Joanna Reszeć, Natalia Marcińczyk, Robert J. Carroll, Paul A. Janmey, J. M. Schwarz, Robert Bucki, Alison E. Patteson Dec 2021

Extracellular Vimentin As A Target Against Sars-Cov-2 Host Cell Invasion, Łukasz Suprewicz, Maxx Swoger, Sarthak Gupta, Ewelina Piktel, Fitzroy J. Byfield, Daniel V. Iwamoto, Danielle Germann, Joanna Reszeć, Natalia Marcińczyk, Robert J. Carroll, Paul A. Janmey, J. M. Schwarz, Robert Bucki, Alison E. Patteson

Physics - All Scholarship

Infection of human cells by pathogens, including SARS-CoV-2, typically proceeds by cell surface binding to a crucial receptor. The primary receptor for SARS-CoV-2 is the angiotensin-converting enzyme 2 (ACE2), yet new studies reveal the importance of additional extracellular co-receptors that mediate binding and host cell invasion by SARS-CoV-2. Vimentin is an intermediate filament protein that is increasingly recognized as being present on the extracellular surface of a subset of cell types, where it can bind to and facilitate pathogens’ cellular uptake. Biophysical and cell infection studies are done to determine whether vimentin might bind SARS-CoV-2 and facilitate its uptake. Dynamic …


Discovery Of Phosphotyrosine-Binding Oligopeptides With Supramolecular Target Selectivity, Ana S. Pina, Leonor Morgado, Krystyna L. Duncan, Sara Carvalho, Henrique F. Carvalho, Armenio J. M. Barbosa, Beatriz De P. Mariz, Ines P. Moreira, Daniela Kalafatovic, Bruno M. Morais Faustino, Vishal Narang, Tong Wang, Charalampos G. Pappas, Isabel Ferreira, A. Cecılia A. Roque, Rein V. Ulijn Dec 2021

Discovery Of Phosphotyrosine-Binding Oligopeptides With Supramolecular Target Selectivity, Ana S. Pina, Leonor Morgado, Krystyna L. Duncan, Sara Carvalho, Henrique F. Carvalho, Armenio J. M. Barbosa, Beatriz De P. Mariz, Ines P. Moreira, Daniela Kalafatovic, Bruno M. Morais Faustino, Vishal Narang, Tong Wang, Charalampos G. Pappas, Isabel Ferreira, A. Cecılia A. Roque, Rein V. Ulijn

Advanced Science Research Center

We demonstrate phage-display screening on self-assembled ligands that enables the identification of oligopeptides that selectively bind dynamic supramolecular targets over their unassembled counterparts. The concept is demonstrated through panning of a phage-display oligopeptide library against supramolecular tyrosine-phosphate ligands using 9-fluorenylmethoxycarbonyl-phenylalanine-tyrosine-phosphate (Fmoc-FpY) micellar aggregates as targets. The 14 selected peptides showed no sequence consensus but were enriched in cationic and proline residues. The lead peptide, KVYFSIPWRVPM-NH2 (P7) was found to bind to the Fmoc-FpY ligand exclusively in its self-assembled state with KD = 74 ± 3 μM. Circular dichroism, NMR and molecular dynamics simulations revealed that the peptide interacts with Fmoc-FpY …


Hiv/Aids After The Crisis: The Evolution Of An Epidemic, Emma Paras Dec 2021

Hiv/Aids After The Crisis: The Evolution Of An Epidemic, Emma Paras

Honors Projects

HIV and AIDS has affected the world for over four decades. In the past, a positive HIV diagnosis could very well be a death sentence, as well as signal that an individual was a social outcast. In the past ten years, however, treatments for HIV/AIDS allow a person to live a long and relatively healthy life. In addition to examining current and future trends in HIV treatment, this paper will also discuss how the virus affects different regions of the world. Particularly in certain parts of Africa, HIV/AIDS remains deadly for many who don’t have proper access to health care …


Synthesis, Structure-Activity Relationship And Antiviral Activity Of Indole-Containing Inhibitors Of Flavivirus Ns2b-Ns3 Protease, Shenyou Nie, Jidong Zhao, Xiaowei Wu, Yuan Yao, Fangrui Wu, Yi-Lun Lin, Xin Li, Alexander R Kneubehl, Megan B Vogt, Rebecca Rico-Hesse, Yongcheng Song Dec 2021

Synthesis, Structure-Activity Relationship And Antiviral Activity Of Indole-Containing Inhibitors Of Flavivirus Ns2b-Ns3 Protease, Shenyou Nie, Jidong Zhao, Xiaowei Wu, Yuan Yao, Fangrui Wu, Yi-Lun Lin, Xin Li, Alexander R Kneubehl, Megan B Vogt, Rebecca Rico-Hesse, Yongcheng Song

Faculty, Staff and Students Publications

Zika virus belongs to the Flavivirus family of RNA viruses, which include other important human pathogens such as dengue and West Nile virus. There are no approved antiviral drugs for these viruses. The highly conserved NS2B-NS3 protease of Flavivirus is essential for the replication of these viruses and it is therefore a drug target. Compound screen followed by medicinal chemistry optimization yielded a novel series of 2,6-disubstituted indole compounds that are potent inhibitors of Zika virus protease (ZVpro) with IC50 values as low as 320 nM. The structure-activity relationships of these and related compounds are discussed. Enzyme kinetics studies show …


Forage Yield And Nutritive Value Of Spring Oats For Various Cultivars And Planting Dates At The Middle Mountain Area, S. Seo, W. H. Kim, D. E. Shin, G. J. Choi, G. J. Park Dec 2021

Forage Yield And Nutritive Value Of Spring Oats For Various Cultivars And Planting Dates At The Middle Mountain Area, S. Seo, W. H. Kim, D. E. Shin, G. J. Choi, G. J. Park

IGC Proceedings (1977-2023)

The experiment was carried out to determine the optimum cultivars and effects of planting date on growth, forage yield and nutritive value of spring sown oats (Avena sativa L.) at the middle mountainous area, Namwon, NLRI, Korea, 1998. The cultivars used in this study was Cayuse, Swan, Foothill, Cashel, Martlock and Winjardie, and the planting dates were 9, 14, 19, 24 and 29 March, and all the forages were harvested on 9 June. Swan among spring oats was the earliest heading type (21 May), and then Martlock (25 May), Winjardie (27 May), and Foothill was the latest (14 June). …


Performance Of Steers In Brachiaria Decumbens Pastures, Permanent And In Rotation With Soybean, L. A. Z. Machado, A. C. Fabrício, J. C. Salton Dec 2021

Performance Of Steers In Brachiaria Decumbens Pastures, Permanent And In Rotation With Soybean, L. A. Z. Machado, A. C. Fabrício, J. C. Salton

IGC Proceedings (1977-2023)

The integration agriculture/pasture is an alternative that allows countless benefits to the rural producer. At Embrapa Agricultural West four production systems were studied and two of them involved animal production. The systems Soybean/Pasture Rotation and Permanent Pasture were compared from september/98 to may/99. The availability and residue of dry matter of green leaves blades (DMGLB), stems (SDM) and senescent material, the gain/animal and gain/area was evaluated. The availability was monthly assessed. Herbage residue was higher in the Soybean/Pasture Rotation system. This system allowed gain/animal and gain/ha of 0.814 kg/day and 582 kg/ha, respectively, whereas the Permanent Pasture system the gain …


Alternative Cropping Systems With Self Reseeding Annual Legumes In A Mediterranean Environment, E. Campiglia, F. Caporali, R. Mancinelli Dec 2021

Alternative Cropping Systems With Self Reseeding Annual Legumes In A Mediterranean Environment, E. Campiglia, F. Caporali, R. Mancinelli

IGC Proceedings (1977-2023)

Self-reseeding winter annual legumes (subclover and snail medic) have the potential to induce a significant shift towards a less energy-intensive and more environmentally friendly management in the modern and specialized cereal cropping systems. Nevertheless their use is practically unknown in mixed stands with winter cereals, where they can contribute to supply nitrogen and to reduce herbicides input. We conceived an alternative cropping system where an annual legume performs, respectively, as living mulch in a winter cereal (winter wheat), as a cover crop after reseeding and as dry mulch for the succeeding summer cereal (corn). Trials carried out at the Tuscia …


Integration Of Cattle And Improved Pastures Under Coconuts In Southern Luzon, Philippines, F. A. Moog, H. E. Diesta, A. G. Deocareza Dec 2021

Integration Of Cattle And Improved Pastures Under Coconuts In Southern Luzon, Philippines, F. A. Moog, H. E. Diesta, A. G. Deocareza

IGC Proceedings (1977-2023)

Results of two studies involving 1) grazing of Signalgrass (Brachiaria decumbens) pastures at different stocking and 2) cut-and-carry forages in smallholder farms for cattle under coconuts are presented. Grazing at 3 AU/ha and 2 AU/ha gave significantly higher LWG/ha (P 0.05) over 1 AU/ha but highest financial return was obtained from 2 AU/ha. Productivity of cattle on cut-and-carry forages in small farms varies among farmers with better animal performance directly related to quantity and quality of feeds offered and industriousness of individual farmers. Both studies showed the benefits derived from integration of cattle with improved pastures under coconuts.


Legumes For Organic Cropping Systems, F. Caporali, R. Mancinelli, E. Campiglia Dec 2021

Legumes For Organic Cropping Systems, F. Caporali, R. Mancinelli, E. Campiglia

IGC Proceedings (1977-2023)

A field experiment which focuses on the yield performance of both durum wheat and sunflower included in a twoyear rotation between wheat/subterranean clover and sunflower was carried out in an organic farm in Central Italy. Three factors were included in the experiment according to a factorial design: a) two different previous crop sequences (four years of alfalfa, four years of annual crops); b) three fertilization levels (without and with animal manure incorporated at 15 or 40 cm depth); c) three durum wheat genotypes (Appulo, Arcangelo and Daunia cvs). The results obtained show that a previous alfalfa meadow allows the succeeding …


Understanding The Effect Of Dietary Palmitic Acid On Glycolysis During Innate Immune Memory In Macrophages, Khaleda A. Aqaei Dec 2021

Understanding The Effect Of Dietary Palmitic Acid On Glycolysis During Innate Immune Memory In Macrophages, Khaleda A. Aqaei

PSU McNair Scholars Online Journal

Trained immunity is long-term innate immune memory induced by a primary stimulus, which leads to hyper-inflammation upon secondary stimulation with a homologous or heterologous ligand. Trained immunity is mediated by epigenetic and metabolic reprogramming of the target cell and leads to modification of gene expression and cellular function. Classically, trained immunity is initiated by b-glucans, an inflammatory molecule found on the exterior of fungal species. Interestingly, our lab has recently described that dietary fatty acids can initiate trained immunity, working through similar pathways as b-glucans. Specifically, our data show that a pre-treatment with a specific dietary saturated fatty acid (SFA), …


A Perusal On Preservation And Conservation Techniques In The Government Aided College Libraries Of Diamond Harbour And Alipore Subdivision In South 24 Parganas, Bibhash Ram Singha ,Librarian, Bikash Kumar Halder Librarian Dec 2021

A Perusal On Preservation And Conservation Techniques In The Government Aided College Libraries Of Diamond Harbour And Alipore Subdivision In South 24 Parganas, Bibhash Ram Singha ,Librarian, Bikash Kumar Halder Librarian

Library Philosophy and Practice (e-journal)

The present study is exhibited the preservation and conservation techniques in the college libraries of Diamond Harbour and Alipore subdivisions in the district of South 24parganas. It is also discusses about degradation problems of print and non-print materials, causes of deterioration of library documents and different obstacles to use preservation techniques. To secure the library materials in a well manner need to apply the preservation and conservation techniques which includes cleaning and dusting, use of insecticides and insect repellent such as Thymol, Dichlorovos, Dursban, Naphthalene balls, Neem leaf etc., besides that there is a provision for security systems of the …


Effect Of Mechanical Systems In Combating The Schistosomiasis Snails, Sherine Ahmed El Baradei Dec 2021

Effect Of Mechanical Systems In Combating The Schistosomiasis Snails, Sherine Ahmed El Baradei

Archived Theses and Dissertations

No abstract provided.


Effects Of Preservation With Pre-Fermented Green Juice (Fgj) On Fermentation Quality And Energy And Nitrogen Utilization Of Round-Baled Alfalfa Silage By Dairy Cattle, Li-Man Cao, Yoshitaka Deguchi, M. Mizutani, M. Goto, Y. Yamamoto, S. Urakawa, Y. Yamada, M. Matsui, T. Masuko, Yasuhiro Kawamoto Dec 2021

Effects Of Preservation With Pre-Fermented Green Juice (Fgj) On Fermentation Quality And Energy And Nitrogen Utilization Of Round-Baled Alfalfa Silage By Dairy Cattle, Li-Man Cao, Yoshitaka Deguchi, M. Mizutani, M. Goto, Y. Yamamoto, S. Urakawa, Y. Yamada, M. Matsui, T. Masuko, Yasuhiro Kawamoto

IGC Proceedings (1977-2023)

This study was conducted to examine the effects of pre-fermented green juice (FGJ) of epiphytic lactic acid bacteria (LAB) on the fermentation quality and animal performance of round-baled alfalfa silage (Medicago stativa L.,cv. Dupuits). Ensiling treatments of wilting and FGJ additives (WFGJ) and direct-cut and FGJ additives (DFGJ) improved the fermentation quality of alfalfa silage more than that of wilting (W). Enhanced fermentation in the WFGJ and DFGJ silage was also associated with the increases of energy and nitrogen utilization of the silage by dry Holstein dairy cattle, as fed on diets formulated with alfalfa silage, oat …


Effect Of Application Of Farmyard Manure To Ley On Forage Yield And Quality Of Grass Silage, T. M. Pauly, L. Rodhe Dec 2021

Effect Of Application Of Farmyard Manure To Ley On Forage Yield And Quality Of Grass Silage, T. M. Pauly, L. Rodhe

IGC Proceedings (1977-2023)

A two-year field trial was performed on ley near Uppsala, Sweden, with the following treatments (3 plots/treatment): A, no manure or fertiliser; B, manure applied in Oct.; C, manure applied in Oct. followed by rolling plots in May; D, manure applied in May; E, mineral fertiliser only. Apart from cattle manure, plots allocated to treatments B, C and D received the same amount of mineral nutrients as treatment E. The objective of this experiment was to get an indication of how different times of manure application (before or after the growth period) affected forage yields and the quality of the …


The Effects Of Cellulase On Cell Wall Structure And The Rumen Digestion Of Alfalfa Silage, T. Ishida, A. Aisan, K. Tomiyama, T. Watanabe, H. Terui, E. No, K. Ataku Dec 2021

The Effects Of Cellulase On Cell Wall Structure And The Rumen Digestion Of Alfalfa Silage, T. Ishida, A. Aisan, K. Tomiyama, T. Watanabe, H. Terui, E. No, K. Ataku

IGC Proceedings (1977-2023)

First- and second-cut alfalfa (Medicago sativa) was ensiled with no additive, microbial (Lactobacillus casei) inoculant, cellulase derived from Acremonium celluloytics Y-94, co-addition of inoculant and cellulase, and formic acid. The resultant silages were digested in the rumen of a dairy cow. The alfalfa and the silages were then examined with scanning electron microscope (SEM) and their chemical characteristics analyzed to evaluate the effects of cellulase on the quality of alfalfa silage and its cell wall structure.

The addition of cellulase lend to both a greater loss of parenchymal tissue and decrease in digestibility during rumen degradation …


Small Mammal Community Ecology And Ectoparasite Dynamics In A Tamaulipan Thornscrub Habitat, Brandi Giles Dec 2021

Small Mammal Community Ecology And Ectoparasite Dynamics In A Tamaulipan Thornscrub Habitat, Brandi Giles

Theses and Dissertations

Small mammals play many roles in ecosystems and are known as great indicators of overall ecosystem function and health, but they are also highly competent hosts for ticks and tick-borne disease. In this study, I gathered data on small mammal community ecology and species diversity, abundance, and overall ectoparasite (i.e., ticks) dynamics in a south Texas Tamaulipan thornscrub habitat. I also assessed differences in these parameters in edge versus interior habitats across a gradient of habitat fragmentation and species assemblage. Lastly, I assessed which host and environmental factors can be utilized for predicting parasitization of small mammals in this habitat. …


Assessing And Improving Political Learning And Engagement On College Campuses, Catherine A. Copeland, Leah Murray Dec 2021

Assessing And Improving Political Learning And Engagement On College Campuses, Catherine A. Copeland, Leah Murray

eJournal of Public Affairs

The American Association for State Colleges and University’s (AASCU’s) American Democracy Project (ADP) and the Institute for Democracy and Higher Education (IDHE), located at Tufts University’s Jonathan M. Tisch College of Civic Life, formed a three-year partnership to pilot a process for fostering institutional change to advance political learning and engagement on college campuses. The multidimensional approach to collecting information, deploying dialogues, and crafting interventions provided insight into the necessity of generating institutional support for civic engagement initiatives.

This article reviews the goals, plan, and process of this three-year, multi-phased initiative. We weave throughout the results of multi-stage evaluations of …


Enhancing Civic Engagement Through Leadership Education, Lori E. Kniffin, Sonalini Sapra Dec 2021

Enhancing Civic Engagement Through Leadership Education, Lori E. Kniffin, Sonalini Sapra

eJournal of Public Affairs

Many civic engagement courses require students to work with community members to make progress on complex problems, which in itself can be a practice of leadership. Yet there is little evidence that leadership development is strategically incorporated in civic engagement courses. Therefore, we taught eight leadership sessions over two semesters in the Principled Problem Solving Scholars Program at Guilford College. This study examines the perceived impact of leadership curriculum on the personal practices of leadership and the civic engagement for 14 undergraduate students. We present the findings through three themes highlighting (1) the shifts in the students’ philosophies of leadership …


Feature: The American Democracy Project, Catherine A. Copeland Dec 2021

Feature: The American Democracy Project, Catherine A. Copeland

eJournal of Public Affairs

For the ADP Feature section of the November 2021 issue


Stink Bug (Hemiptera: Heteroptera: Pentatomidae) Ecology In Nebraska Agroecosystems, Blessing Ademokoya Dec 2021

Stink Bug (Hemiptera: Heteroptera: Pentatomidae) Ecology In Nebraska Agroecosystems, Blessing Ademokoya

Department of Entomology: Dissertations, Theses, and Student Research

Stink bugs (Hemiptera: Heteroptera: Pentatomidae) have gained considerable attention in Nebraska in the last decade due to increasing densities of native stink bug and spread of invasive species in the Midwest. Little is known about stink bug dynamics in Nebraska cropping systems. Based on data from a recent field survey, specimens at the University of Nebraska State Museum and the diagnostic lab of the Entomology Department at the University of Nebraska Lincoln, as well as published literature, we present a checklist of 72 species and subspecies of Pentatomidae (55 Pentatominae, 13 Asopinae, 3 Podopinae and 1 Edessinae) that occur in …


Cellular Agriculture: An Outlook On Smart And Resilient Food Agriculture Manufacturing, Salil Bapat, Vishvesh Koranne, Neha Shakelly, Aihua Huang, Michael Sealy, Kamlakar P. Rajurkar, John W. Sutherland, Ajay P. Malshe Dec 2021

Cellular Agriculture: An Outlook On Smart And Resilient Food Agriculture Manufacturing, Salil Bapat, Vishvesh Koranne, Neha Shakelly, Aihua Huang, Michael Sealy, Kamlakar P. Rajurkar, John W. Sutherland, Ajay P. Malshe

School of Mechanical Engineering Faculty Publications

Over the centuries, the application of grassland and cutting of livestock are the primary foundations for
the production of food agriculture manufacturing. Growing human population, accelerated human
activities globally, staggering food inequity, changing climate, precise nutrition for extended life
expectancy, and more demand for protein food call for a new outlook to smartness in food agriculture
manufacturing for delivering nutritious food. Cellular agriculture, 3D printing of food, vertical urban
farming, and digital agriculture alongside traditional means are envisioned to transform food agriculture
and manufacturing systems for acceptability, availability, accessibility, affordability, and resiliency for meeting demands of food in this century …


The Montclarion, December 2, 2021, The Montclarion Dec 2021

The Montclarion, December 2, 2021, The Montclarion

The Montclarion

Student Newspaper of Montclair State University


Association Of Low-Frequency And Rare Coding Variants With Information Processing Speed, Jan Bressler, Gail Davies, Albert V Smith, Yasaman Saba, Joshua C Bis, Xueqiu Jian, Caroline Hayward, Lisa Yanek, Jennifer A Smith, Saira S Mirza, Ruiqi Wang, Hieab H H Adams, Diane Becker, Eric Boerwinkle, Archie Campbell, Simon R Cox, Gudny Eiriksdottir, Chloe Fawns-Ritchie, Rebecca F Gottesman, Megan L Grove, Xiuqing Guo, Edith Hofer, Sharon L R Kardia, Maria J Knol, Marisa Koini, Oscar L Lopez, Riccardo E Marioni, Paul Nyquist, Alison Pattie, Ozren Polasek, David J Porteous, Igor Rudan, Claudia L Satizabal, Helena Schmidt, Reinhold Schmidt, Stephen Sidney, Jeannette Simino, Blair H Smith, Stephen T Turner, Sven J Van Der Lee, Erin B Ware, Rachel A Whitmer, Kristine Yaffe, Qiong Yang, Wei Zhao, Vilmundur Gudnason, Lenore J Launer, Annette L Fitzpatrick, Bruce M Psaty, Myriam Fornage, M Arfan Ikram, Cornelia M Van Duijn, Sudha Seshadri, Thomas H Mosley, Ian J Deary Dec 2021

Association Of Low-Frequency And Rare Coding Variants With Information Processing Speed, Jan Bressler, Gail Davies, Albert V Smith, Yasaman Saba, Joshua C Bis, Xueqiu Jian, Caroline Hayward, Lisa Yanek, Jennifer A Smith, Saira S Mirza, Ruiqi Wang, Hieab H H Adams, Diane Becker, Eric Boerwinkle, Archie Campbell, Simon R Cox, Gudny Eiriksdottir, Chloe Fawns-Ritchie, Rebecca F Gottesman, Megan L Grove, Xiuqing Guo, Edith Hofer, Sharon L R Kardia, Maria J Knol, Marisa Koini, Oscar L Lopez, Riccardo E Marioni, Paul Nyquist, Alison Pattie, Ozren Polasek, David J Porteous, Igor Rudan, Claudia L Satizabal, Helena Schmidt, Reinhold Schmidt, Stephen Sidney, Jeannette Simino, Blair H Smith, Stephen T Turner, Sven J Van Der Lee, Erin B Ware, Rachel A Whitmer, Kristine Yaffe, Qiong Yang, Wei Zhao, Vilmundur Gudnason, Lenore J Launer, Annette L Fitzpatrick, Bruce M Psaty, Myriam Fornage, M Arfan Ikram, Cornelia M Van Duijn, Sudha Seshadri, Thomas H Mosley, Ian J Deary

Faculty, Staff and Student Publications

Measures of information processing speed vary between individuals and decline with age. Studies of aging twins suggest heritability may be as high as 67%. The Illumina HumanExome Bead Chip genotyping array was used to examine the association of rare coding variants with performance on the Digit-Symbol Substitution Test (DSST) in community-dwelling adults participating in the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium. DSST scores were available for 30,576 individuals of European ancestry from nine cohorts and for 5758 individuals of African ancestry from four cohorts who were older than 45 years and free of dementia and …


High-Throughput Functional Analysis Of Cftr And Other Apically Localized Proteins In Ipsc-Derived Human Intestinal Organoids, Sunny Xia, Zoltán Bozóky, Michelle Di Paola, Onofrio Laselva, Saumel Ahmadi, Jia Xin Jiang, Amy L Pitstick, Chong Jiang, Daniela Rotin, Christopher N Mayhew, Nicola L Jones, Christine E Bear Dec 2021

High-Throughput Functional Analysis Of Cftr And Other Apically Localized Proteins In Ipsc-Derived Human Intestinal Organoids, Sunny Xia, Zoltán Bozóky, Michelle Di Paola, Onofrio Laselva, Saumel Ahmadi, Jia Xin Jiang, Amy L Pitstick, Chong Jiang, Daniela Rotin, Christopher N Mayhew, Nicola L Jones, Christine E Bear

Open Access Publications

Induced Pluripotent Stem Cells (iPSCs) can be differentiated into epithelial organoids that recapitulate the relevant context for CFTR and enable testing of therapies targeting Cystic Fibrosis (CF)-causing mutant proteins. However, to date, CF-iPSC-derived organoids have only been used to study pharmacological modulation of mutant CFTR channel activity and not the activity of other disease-relevant membrane protein constituents. In the current work, we describe a high-throughput, fluorescence-based assay of CFTR channel activity in iPSC-derived intestinal organoids and describe how this method can be adapted to study other apical membrane proteins. Specifically, we show how this assay can be employed to study …


Primacy And Recency Effects On Position Error In Short-Term Memory Recall, Weerachet Sinlapanuntakul, Kelly Harris, Brittany S. Wesley Dec 2021

Primacy And Recency Effects On Position Error In Short-Term Memory Recall, Weerachet Sinlapanuntakul, Kelly Harris, Brittany S. Wesley

Beyond: Undergraduate Research Journal

Position error is the most common error in serial recall of short-term memory, especially when environment, language, or similarity factors are presented. Previous studies demonstrate some support for the serial recall resulting in less error-prone for the first and last positions than the middle positions. This study investigates the accuracy of recalling letters and their positions when given a random sequence with minimal to no external factors. The significant predictors influencing position error were the primacy and recency effects. Participants completed a 20-trial experiment on the CogLab Experimental Control Software, which presented a series of letters one at a time …


Mechanical Overload-Induced Muscle-Derived Extracellular Vesicles Promote Adipose Tissue Lipolysis, Ivan J. Vechetti Jr, Bailey D. Peck, Yuan Wen, R Grace Walton, Taylor R. Valentino, Alexander P. Alimov, Cory M. Dungan, Douglas W. Van Pelt, Ferdinand Von Walden, Bjorn Alkner, Charlotte A. Peterson, John J. Mccarthy Dec 2021

Mechanical Overload-Induced Muscle-Derived Extracellular Vesicles Promote Adipose Tissue Lipolysis, Ivan J. Vechetti Jr, Bailey D. Peck, Yuan Wen, R Grace Walton, Taylor R. Valentino, Alexander P. Alimov, Cory M. Dungan, Douglas W. Van Pelt, Ferdinand Von Walden, Bjorn Alkner, Charlotte A. Peterson, John J. Mccarthy

Department of Nutrition and Health Sciences: Faculty Publications

How regular physical activity is able to improve health remains poorly understood. The release of factors from skeletal muscle following exercise has been proposed as a possible mechanism mediating such systemic benefits. We describe a mechanism wherein skeletal muscle, in response to a hypertrophic stimulus induced by mechanical overload (MOV), released extracellular vesicles (EVs) containing muscle-specific miR-1 that were preferentially taken up by epidydimal white adipose tissue (eWAT). In eWAT, miR-1 promoted adrenergic signaling and lipolysis by targeting Tfap2α, a known repressor of Adrβ3 expression. Inhibiting EV release prevented the MOV-induced increase in eWAT miR-1 abundance and expression of …


Self-Extending Symbiosis In Symbiodinium Microadriaticum And The Effect Of Endosymbiotic / Horizontal Gene Transfer On Dinoflagellates And The Tree Of Life, Maha Kadry Ahmed Fathy Dec 2021

Self-Extending Symbiosis In Symbiodinium Microadriaticum And The Effect Of Endosymbiotic / Horizontal Gene Transfer On Dinoflagellates And The Tree Of Life, Maha Kadry Ahmed Fathy

Archived Theses and Dissertations

Symbiodinium microadriaticum is a dinoflagellate that lives in a mutualistic relationship with the coral Stylophora pistillata in the Red Sea. Symbiodinium microadriaticum is divided into several clades and the A1 clade of Symbiodinium microadriaticum lives in shallow waters and is resilient to thermal stress. The association between Symbiodinium microadriaticum A1 and Stylophora pistillata enables Stylophora pistillata to tolerate the rise in the sea surface temperature caused by global warming and climate change. Here, the first completely sequenced dinoflagellate genome is explored to answer two questions: The first question is whether self-extending symbiosis has a role in the ability of Symbiodinium …