Digital Commons Network^™

Treatment Of Full-Thickness Acetabular Chondral Flaps During Hip Arthroscopy: Bone Marrow Aspirate Concentrate Versus Microfracture, Michael P. Kucharik, Paul F. Abraham, Mark R. Nazal, Nathan H. Varady, Christopher T. Eberlin, Wendy M. Meek, Sara A. Naessig, Scott D. Martin

Orthopaedic Surgery and Sports Medicine Resident Research

Background: The optimal treatment strategy for patients with full-thickness chondral flaps undergoing hip arthroscopy is controversial.

Purpose: To compare functional outcomes of patients who underwent bone marrow aspirate concentrate (BMAC) application with those of patients who underwent microfracture.

Study Design: Cohort study; Level of evidence, 3.

Methods: This was a retrospective case series of prospectively collected data on patients who underwent arthroscopic acetabular labral repair by 1 surgeon between June 2014 and April 2020. The inclusion criteria for this study were age ≥18 years, preoperative radiographs of the pelvis, arthroscopic acetabular labral repair, exposed subchondral bone with overlying chondral flap …

Public Intellectuals In The Age Of Viral Modernity: An Epat Collective Writing Project, Michael A. Peters, Petar Jandrić, Steve Fuller, Alexander J. Means, Sharon Rider, George Lăzăroiu, Sarah Hayes, Greg William Misiaszek, Marek Tesar, Peter Mclaren, Ronald Barnett

Education Faculty Articles and Research

No abstract provided.

Preliminary Tests Of Dosimetric Quality And Projected Therapeutic Outcomes Of Multi-Phase 4d Radiotherapy With Proton And Carbon Ion Beams, Michelle Lis, Wayne Newhauser, Marco Donetti, Moritz Wolf, Timo Steinsberger, Athena Paz, Christian Graeff

Faculty Publications

Objective. The purpose of this study was to perform preliminary pre-clinical tests to compare the dosimetric quality of two approaches to treating moving tumors with ion beams: synchronously delivering the beam with the motion of a moving planning target volume (PTV) using the recently developed multi-phase 4D dose delivery (MP4D) approach, and asynchronously delivering the ion beam to a motion-encompassing internal tumor volume (ITV) combined with rescanning. Approach. We created 4D optimized treatment plans with proton and carbon ion beams for two patients who had previously received treatment for non-small cell lung cancer. For each patient, we created several treatment …

Eyewitness Identification, Alley Chan

Honors Theses

Eyewitness identification often plays a crucial role in the criminal justice system. It can be used to make an arrest, both exonerate and convict suspects, fuel police interrogation, and influence a plea bargaining decision. In the meantime, eyewitness misidentification has contributed to approximately 69% of the wrongful convictions, making it the leading factor in wrongful convictions nationwide. Hence, the central question that will be explored in this thesis is: Why eyewitness testimony is so powerful despite it is prone to error? To answer this question, this thesis will examine the role of eyewitness identification played in the criminal justice system …

Hypothalamic Steroid Receptor Coactivator-2 Regulates Adaptations To Fasting And Overnutrition, Yongjie Yang, Yanlin He, Hailan Liu, Wenjun Zhou, Chunmei Wang, Pingwen Xu, Xing Cai, Hesong Liu, Kaifan Yu, Zhou Pei, Ilirjana Hyseni, Makoto Fukuda, Qingchun Tong, Jianming Xu, Zheng Sun, Bert W. O'Malley, Yong Xu

Division of Basic Science Faculty Publications

The neuroendocrine system coordinates metabolic and behavioral adaptations to fasting, including reducing energy expenditure, promoting counterregulation, and suppressing satiation and anxiety to engage refeeding. Here, we show that steroid receptor coactivator-2 (SRC-2) in pro-opiomelanocortin (POMC) neurons is a key regulator of all these responses to fasting. POMC-specific deletion of SRC-2 enhances the basal excitability of POMC neurons; mutant mice fail to efficiently suppress energy expenditure during food deprivation. SRC-2 deficiency blunts electric responses of POMC neurons to glucose fluctuations, causing impaired counterregulation. When food becomes available, these mutant mice show insufficient refeeding associated with enhanced satiation and discoordination of anxiety …

Annotated Checklist Of Invertebrate Species Observed At The Gordon Natural Area (West Chester University, Pa) 2007-2021. Version Iii, Nur Ritter

Gordon Natural Area Biodiversity Studies Documents

Description: As with some of the other biotic groups, the research pattern for invertebrates at the GNA might best be described as ‘intermittent.’ Former WCU professor Win Fairchild and his students conducted research on aquatic invertebrates in Plum Run, both inside and outside of the boundaries of the GNA. To date, the only data from that work that we’ve been able to obtain are from the 2007 MS thesis of Danielle DiFederico.

Since that time, the only ‘directed’ invertebrate research at the GNA has been the annual monitoring in Plum Run by the Stroud Water Research Center (SWRC). This research …

Applying Integrative Systematics To Long-Standing Species Boundary Questions In The Zoanthidea, Annika Markovich

All HCAS Student Capstones, Theses, and Dissertations

The study of systematics has been around for over 200 years. Some recent systematic studies have shifted to the idea of genetic barcoding for identification and classification. This shift is notably present in the cnidarian order Zoanthidea. Systematists have employed genetic barcoding exclusively for the classification of these animals resulting in taxonomic uncertainty. A prominent Mediterranean species complex (Parazoanthus axinellae) is at the center of these taxonomic issues. Recently two color-morpho-types: “slender” yellow and “stocky” orange have been used to differentiate modern P. axinellae specimens, advancing the uncertainty associated with this complex. This lack of taxonomic identity becomes …

Baphia Macrocalyx Leaf Extract Attenuates Rotenone-Induced Toxicity In Drosophila Melanogaster Model Of Parkinson’S Disease, Flora Stephano

Journal of Humanities and Social Sciences

Parkinson’s disease (PD) is a motor disorder mostly affecting aged people, with not known standard therapy. The use of natural products is increasingly gaining attention for the treatment of different diseases. Baphia macrocalyx is a plant previously associated with antioxidant activities in in vitro studies. Thus, the aim of this study was to evaluate the ameliorative potential of methanolic leaf extract of Baphia macrocalyx (MEBM) on rotenone-triggered toxicity in Drosophila melanogaster. To this end, the study used a neurotoxin, rotenone, to induce PD in the fruit-fly to create a chemical PD in vivo model. Using biochemical, behavioural and molecular analyses, …

Unh Research Finds Future Snowmelt Could Have Costly Consequences On Infrastructure, Robbin Ray

Media Relations

No abstract provided.

Windblown Transport Of Toxic Metals In Airborne Particulate Matter Near The Jackpile-Paguate Uranium Mine On Laguna Pueblo, New Mexico, Savannah S. Larosa-Lopresti

Earth and Planetary Sciences ETDs

Abandoned uranium mines across the U.S. disproportionately affect indigenous communities who suffer numerous intergenerational health consequences from chronic exposure to toxic metal mixtures. The Jackpile-Paguate Uranium Mine on Laguna Pueblo in west-central New Mexico was designated a Superfund Site in 2013 and exposure risks from inhalation of toxic metals in airborne particulate matter are of concern for the local tribal communities. This research aims to examine atmospheric parameters driving windblown transport of respirable particulate matter in the region, to determine concentrations of heavy metals including U, V, Pb, and As due to the link with potential health risks, and to …

Glacier Retreat Creating New Pacific Salmon Habitat In Western North America, Kara J. Pitman, Jonathan W. Moore, Matthias Huss, Matthew R. Sloat, Diane C. Whited, Tim J. Beechie, Rich Brenner, Eran Hood, Alexander M. Milner, George R. Pess, Gordan H. Reeves, Daniel E. Schindler

Faculty, Staff, and Students

Glacier retreat poses risks and benefits for species of cultural and economic importance. One example is Pacific salmon (Oncorhynchus spp.), supporting subsistence harvests, and commercial and recreational fisheries worth billions of dollars annually. Although decreases in summer streamflow and warming freshwater is reducing salmon habitat quality in parts of their range, glacier retreat is creating new streams and lakes that salmon can colonize. However, potential gains in future salmon habitat associated with glacier loss have yet to be quantified across the range of Pacific salmon. Here we project future gains in Pacific salmon freshwater habitat by linking a model of …

Keratin 1 As A Cell-Surface Receptor In Cancer, Oluseye Ogunnigbagbe, Christopher G. Bunick, Kamaljit Kaur

Pharmacy Faculty Articles and Research

Keratins are fibrous proteins that take part in several important cellular functions, including the formation of intermediate filaments. In addition, keratins serve as epithelial cell markers, which has made their role in cancer progression, diagnosis, and treatment an important focus of research. Keratin 1 (K1) is a type II keratin whose structure is comprised of a coiled-coil central domain flanked by flexible, glycine-rich loops in the N- and C-termini. While the structure of cytoplasmic K1 is established, the structure of cell-surface K1 is not known. Several transformed cells, such as cancerous cells and cells that have undergone oxidative stress, display …

Predicting Future Floods, Robbin Ray

UNH Today Archive

No abstract provided.

Validation Of Reference Genes For Quantitative Pcr In The Forest Pest, Ips Calligraphus, Mary Wallace, Lynne K. Rieske

Entomology Faculty Publications

The six-spined ips, Ips calligraphus, is a North American bark beetle that can exploit most eastern North American Pinus species and can cause mortality. Biotic and abiotic disturbances weaken trees, creating breeding substrate that promotes rapid population growth. Management historically relied on silvicultural practices, but as forests become increasingly stressed, innovative management is needed. Manipulation of the cellular RNA interference (RNAi) pathway to induce gene silencing is an emerging means of insect suppression, and is effective for some bark beetles. Quantitative PCR (qPCR) is a powerful tool for analysis of gene expression, and is essential for examining RNAi. To …

Evidence Of Western Corn Rootworm (Diabrotica Virgifera Virgifera Leconte) Field-Evolved Resistance To Cry3bb1 + Cry34/ 35ab1 Maize In Nebraska, Jordan D. Reinders, Emily E. Reinders, Emily Robinson, Bryan W. French, Lance J. Meinke

Department of Entomology: Faculty Publications

BACKGROUND: Western corn rootworm (WCR; Diabrotica virgifera virgifera) field-evolved resistance to transgenic maize expressing the Cry3Bb1 protein derived from Bacillus thuringiensis (Bt) has been confirmed across the United States Corn Belt. Although use of pyramided hybrids expressing Cry3Bb1 + Cry34/35Ab1 has increased in recent years to mitigate existing WCR Bt resistance, susceptibility of Nebraska WCR populations to this rootworm–Bt pyramid has not been assessed. Plant-based bioassays were used to characterize the susceptibility of WCR populations to Cry3Bb1 and Cry3Bb1 + Cry34/35Ab1 maize. Populations were collected from areas of northeastern Nebraska with a history of planting Bt maize that expressed …

Sex-, Race-And Ethnicity-Based Differences In Thromboembolic Events Among Adults Hospitalized With Covid-19, Sadia Ilyas, Stanislav Henkin, Pablo Martinez-Camblor, Bjoern D. Suckow, Jocelyn M. Beach, David H. Stone, Philip P. Goodney, Joseph E. Ebinger, Mark A. Creager, Jesse A. Columbo

Dartmouth Scholarship

BACKGROUND: Patients hospitalized with COVID-19 have an increased risk of thromboembolic events. Whether sex, race or ethnicity impacts these events is unknown. We studied the association between sex, race, and ethnicity and venous and arterial thromboembolic events among adults hospitalized with COVID-19. METHODS AND RESULTS: We used the American Heart Association Cardiovascular Disease COVID-19 registry. Primary expo-sures were sex and race and ethnicity, as defined by the registry. Primary outcomes were venous thromboembolic events and arterial thromboembolic events. We used logistic regression for risk adjustment. We studied 21 528 adults hospitalized with COVID-19 across 107 centers (54.1% men; 38.1% non-Hispanic …

Interrogating Systems That Cause Disparities: Testing The Social-Ecological Model In Low- Versus High-Density African American Communities, Kaprea F. Johnson, Lauren B. Robins, Chelsea Derlan Williams, Tiffany G. Townsend

Journal of Social, Behavioral, and Health Sciences

This study utilized the four-level social-ecological model to provide a better understanding of the disparities in health-related outcomes in high- and low-density African American (AA) communities. The current research sought to understand the relationships between mental and physical health, social-economic factors, and physical environment within this community. The goal of this study was to understand the relationship between these indicators of health, to better inform health-care strategies. The results highlight the significant difference between high- and low-density AA communities and socio-economic factors, physical environment, poor physical days, and poor mental health days. Implications for behavioral health providers are explored.

Experiences Of African American Women Living With Herpes Simplex Virus 2, Cherlisa Jackson, Yitza A. Arcelay-Rojas

Journal of Social, Behavioral, and Health Sciences

In the United States, the prevalence of herpes simplex virus 2 (HSV-2) continues to be the highest among African American women. Yet the perceived benefit of discussing sexual health, as well as recognizing a need to discuss HSV-2 with a health-care provider, is a gap in research. The purpose of this interpretive qualitative study was to understand the experiences of African American women who received an asymptomatic HSV-2 diagnosis. Semistructured interviews of seven participants were used to explore the experiences of African American women diagnosed with HSV-2, including barriers and challenges of discussing HSV-2 with health-care providers. Participants highlighted that …

Drug-Coated Balloon Versus Plain Balloon Angioplasty For Hemodialysis Dysfunction: A Meta-Analysis Of Randomized Controlled Trials, Chenyu Liu, Matthew Wolfers, Bint-E Zainab Awan, Issa Ali, Adrian Michael Lorenzana, Quinn Smith, George Tadros, Qian Yu

Student Publications

Background: Both drug-coated balloon (DCB) angioplasty and conventional plain balloon angioplasty (PBA) can be implemented to treat hemodialysis dysfunction. The present study aims to compare the safety and efficacy of these 2 approaches by conducting a meta-analysis of available randomized controlled trials.

Methods and Results: PubMed, Cochrane Library, and Embase databases were queried from establishment to January 2021. A total of 18 randomized controlled trials including 877 and 875 patients in the DCB and PBA groups, respectively, were included in the present meta-analysis. Target lesion primary patency, circuit patency, target lesion revascularization, and mortality were pooled. Odds ratios (ORs) were …

Broad-Scale Vertical And Horizontal Behavior Of The White Shark (Carcharodon Carcharias) In The Western North Atlantic, Taryn Szalay

All HCAS Student Capstones, Theses, and Dissertations

The ecology of white sharks Carcharodon carcharias in the western North Atlantic (WNA) is largely unknown. With a lack of essential fish habitat (EFH) identified by the National Oceanic and Atmospheric Administration (NOAA), understanding white shark behaviors is crucial to protect aggregation sites and other essential habitats (e.g., mating, parturition) for white sharks. To better understand the movements of these animals, data from 26 tagged white sharks are examined here. Data from the pop-up satellite archival transmitting (PSAT) tags from these sharks were analyzed using the HMMoce package for R (R Development and Core Team 2015) and tracks were generated …

Exposure To Prenatal Maternal Distress And Infant White Matter Neurodevelopment, Catherine H. Demers, Maria M. Bagonis, Khalid Al-Ali, Sarah E. Garcia, Martin A. Styner, John H. Gilmore, M. Camille Hoffman, Benjamin L. Hankin, Elysia Poggi Davis

Psychology: Faculty Scholarship

The prenatal period represents a critical time for brain growth and development. These rapid neurological advances render the fetus susceptible to various influences with life-long implications for mental health. Maternal distress signals are a dominant early life influence, contributing to birth outcomes and risk for offspring psychopathology. This prospective longitudinal study evaluated the association between prenatal maternal distress and infant white matter microstructure. Participants included a racially and socioeconomically diverse sample of 85 mother–infant dyads. Prenatal distress was assessed at 17 and 29 weeks’ gestational age (GA). Infant structural data were collected via diffusion tensor imaging (DTI) at 42–45 weeks’ …

Immunosuppression And Outcomes In Adult Patients With De Novo Acute Myeloid Leukemia With Normal Karyotypes, Francesca Ferraro, Christopher A Miller, Keegan A Christensen, Nichole M Helton, Margaret O'Laughlin, Catrina C Fronick, Robert S Fulton, Jessica Kohlschmidt, Ann-Kathrin Eisfeld, Clara D Bloomfield, Sai Mukund Ramakrishnan, Ryan B Day, Lukas D Wartman, Geoffrey L Uy, John S Welch, Matthew J Christopher, Sharon E Heath, Jack D Baty, Matthew J Schuelke, Jacqueline E Payton, David H Spencer, Michael P Rettig, Daniel C Link, Matthew J Walter, Peter Westervelt, John F Dipersio, Timothy J Ley

Open Access Publications

Acute myeloid leukemia (AML) patients rarely have long first remissions (LFRs; >5 y) after standard-of-care chemotherapy, unless classified as favorable risk at presentation. Identification of the mechanisms responsible for long vs. more typical, standard remissions may help to define prognostic determinants for chemotherapy responses. Using exome sequencing, RNA-sequencing, and functional immunologic studies, we characterized 28 normal karyotype (NK)-AML patients with >5 y first remissions after chemotherapy (LFRs) and compared them to a well-matched group of 31 NK-AML patients who relapsed within 2 y (standard first remissions [SFRs]). Our combined analyses indicated that genetic-risk profiling at presentation (as defined by European …

A Highly Versatile Fungal Glucosyltransferase For Specific Production Of Quercetin-7-O-Β-D-Glucoside And Quercetin-3-O-Β-D-Glucoside In Different Hosts, Jie Ren, Wenzhu Tang, Caleb Don Barton, Owen M. Price, Mark Wayne Mortensen, Alexandra Phillips, Banner Wald, Simon Elgin Hulme, Logan Powell Stanley, Joan Hevel, Jixun Zhan

Biological Engineering Faculty Publications

Glycosylation is an effective way to improve the water solubility of natural products. In this work, a novel glycosyltransferase gene (BbGT) was discovered from Beauveria bassiana ATCC 7159 and heterologously expressed in Escherichia coli. The purified enzyme was functionally characterized through in vitro enzymatic reactions as a UDP-glucosyltransferase, converting quercetin to five monoglucosylated and one diglucosylated products. The optimal pH and temperature for BbGT are 35 ℃ and 8.0, respectively. The activity of BbGT was stimulated by Ca2+, Mg2+, and Mn2+, but inhibited by Zn2+. BbGT enzyme is flexible and can glycosylate a variety of substrates such as curcumin, …

Finding A Home Through The Screen: A Glimpse Into Student Experiences In A World Of Remote Admissions Processes, Megan Carmen

Honors Projects

The college search process is an important time in the life of any student, and feeling a sense of belonging and inclusion through the admissions process is vital to ensuring student success in higher education. With COVID-19 forcing all admissions communications online, student connections were changed and student’s perception of belonging was altered. This confidential survey project used demographic, quantitative, and open-ended questions to understand student perceptions of belonging and inclusion during the online admissions process. Of 750 students contacted, 57 students responded to the demographic questions, 50 to the quantitative questions, and 17 students left in-depth responses about their …

Il-17 And Disease Activity In Spondyloarthitis, Yuliasih, Yusdeny Lanasakti

Folia Medica Indonesiana

Highlight: • The correlation of IL-17 to disease activity by The Ankylosing Spondylitis Disease Activity Score C-Reactive Protein (ASDAS-CRP) was identified. • IL-17 level is strongly correlated to disease activity in SpA patients. Abstract: IL-17 is a new cytokine involved in the pathogenesis of Spondyloarthritis (SpA). Recent studies show that IL-17 level correlates to disease activity, and it is used as a basis in treating SpA patients who do not respond to anti-TNF-α. This study identified the correlation of IL-17 to disease activity measured by The Ankylosing Spondylitis Disease Activity Score C-Reactive Protein (ASDAS-CRP). This study was a cross-sectional study …

High Calorie Diet With A Combination Of Intermittent Restriction Affects The Reproductive Cycle And The Uterine Weight Of Mice (Mus Musculus), Anggraeni Dyah Kumalasari, Lilik Herawati, Raden Argarini, Lina Lukitasari, Zulhabri Othman, Astika Gita Ningrum

Folia Medica Indonesiana

Highlight: • High-calorie diet influence with interval restrictions combination on the reproductive cycle and weight of the uterus in mice were analyzed. • Calories balance impact for female reproductive health. Abstract : Balanced calories affected for body health and daily activities. Lose of energy can disturb the health and daily activities, while over calorie for diets also causes disorders such as metabolic. When there are excess calories in the body will be involved. It can be an obesity risk, diabetes mellitus, fertility disorder, cancer, and cardiovascular disease. Furthermore, in women there can be an increase in menstrual disorders and fertility …

Back Matter Vol. 57 No. 4 December 2021, Back Matter

Folia Medica Indonesiana

No abstract provided.

Hypothalamic Steroid Receptor Coactivator-2 Regulates Adaptations To Fasting And Overnutrition, Yongjie Yang, Yanlin He, Hailan Liu, Wenjun Zhou, Chunmei Wang, Pingwen Xu, Xing Cai, Hesong Liu, Kaifan Yu, Zhou Pei, Ilirjana Hyseni, Makoto Fukuda, Qingchun Tong, Jianming Xu, Zheng Sun, Bert W O'Malley, Yong Xu

Faculty, Staff and Students Publications

The neuroendocrine system coordinates metabolic and behavioral adaptations to fasting, including reducing energy expenditure, promoting counterregulation, and suppressing satiation and anxiety to engage refeeding. Here, we show that steroid receptor coactivator-2 (SRC-2) in pro-opiomelanocortin (POMC) neurons is a key regulator of all these responses to fasting. POMC-specific deletion of SRC-2 enhances the basal excitability of POMC neurons; mutant mice fail to efficiently suppress energy expenditure during food deprivation. SRC-2 deficiency blunts electric responses of POMC neurons to glucose fluctuations, causing impaired counterregulation. When food becomes available, these mutant mice show insufficient refeeding associated with enhanced satiation and discoordination of anxiety …

Effect Of Five Different Rest Periods On Tiller Regrowth Of Ryegrass, R. W. Coelho, W. R. Ocumpaugh

IGC Proceedings (1977-2023)

Five rest periods were imposed from April to May on a mixed pasture of two ryegrass (Lolium multiflorum Lam.) varieties and white clover (Trifolium repens L.). The rest period starting dates were: April 4, April 18, May 2, May 16, and May 30, for rest periods 1, 2, 3, 4, and 5, respectively. The total area allocated to the experiment was 1.1 ha, which was divided into 22 pastures. The experimental design used was a split-plot. Rest period was assigned to the main plot, grass to the subplot and legume to the subsubplot. The pastures were “mob-grazed” by …

Aboveground Standing Crop Of An Ungrazed Elyonurus Muticus Grassland Under Annual Burning In The Pantanal, Brazil, E. L. Cardoso, S. M. A. Crispim, C. A. G. Rodrigues

IGC Proceedings (1977-2023)

This study was conducted in the Pantanal of Mato Grosso do Sul state, Brazil, from September 1995 to July 1997. The objective was to evaluate the effect of annual burning on grasses and forbs biomass and standing dead in an ungrazed grassland of Elyonurus muticus. In two areas, one free of burning (control) and another area with annual burning, grasses, forbs aboveground biomass, and standing dead were collected. The experimental design was completely randomized with 10 replications. Burning modified the grasses and forbs biomass dynamics when compared to the area free of burning. After the first burning the grasses …