Attenuating Effect Of Vitamin E Against Silver Nano Particles Toxicity In Submandibular Salivary Glands, Mahmoud Bakr, Mahmoud Al Ankily, Sara M. Shogaa, Mohamed Shamel

Dentistry

Open AccessArticle

Attenuating Effect of Vitamin E against Silver Nano Particles Toxicity in Submandibular Salivary Glands

Wmu Board Of Trustees Formal Session December 16, 2021, Wmu Board Of Trustees

WMU Board of Trustees Meetings

Acceptance of the Agenda

Approval of the Minutes (November 4, 2021 and November 16, 2021 Meetings)

Remarks by the Chair

Remarks by the President

Updates by the Faculty Senate President

Updates by the Western Student Association President

Updates by the Graduate Student Association Vice President

Community Policing: Campus Safety through Service-Oriented Operation

Annual Presidential Assessment

Public Comments Regarding Action Items

Action Items

• Approval of Capital Expenditure for WMU Homer Stryker M.D. School of Medicine
• Presidential Compensation

Consent Items

• Curriculum Proposals
• Personnel Report
• Revised WMU Duty to Report Criminal Acts Policy
• WMU Lease Agreement with FedEx Office and Print Services
• Annuity …

Noise And Time Pressure Effects On Situation Awareness And Aviation Maintenance Tasks, Syaza R. M. Haris

Doctoral Dissertations and Master's Theses

Aircraft maintenance technicians (AMTs) working in a line maintenance work setting are very susceptible to the deafening occupational noise from the airport vicinity or the maintenance machinery itself. Compared to a base maintenance working period, a line maintenance job requires AMTs to complete a task within a short time frame. The current study's objective is to determine if different noise levels and time pressure influence AMTs' performance and situation awareness (SA). Sixteen Embry-Riddle Aeronautical University students majoring in Aviation Maintenance Science participated in a within-subject experimental design. Each participant's performance, SA level, and perceived workload were measured during maintenance tasks …

Ecological Exposure And Effects Of Microplastics In Crabs Along The Pacific Coast, Dorothy A. Horn

Dissertations and Theses

Microplastics have been documented across the global oceans as an ubiquitous pollutant. Found in the water column, sediment, shorelines, estuaries, freshwater streams and rivers along with terrestrial soils, flora and fauna. The continuous input of plastic waste into the marine environment doesn't seem to be slowing as the amount of plastic created each year increases globally.

This study investigated (1) the effects of microplastic ingestion in the indicator species, the Pacific mole crab (Emerita analoga), testing the predator avoidance behavior, reproductive output and parasitism effects when an adult female gravid crab had ingested microplastics (2) adult mortality, hatching …

Nature-Based Solutions In Environmental Planning: Ecosystem-Based Adaptations, Green Infrastructures, And Ecosystem Services To Promote Diversity In Urban Landscapes, Lorena Alves Carvalho Nascimento

Dissertations and Theses

Nature-based solutions encompass strategies that explore ecosystem-based adaptations, green infrastructures, and ecosystem services in environmental planning and landscape management. However, nature-based solutions do not always consider ecological values and perspectives from Black, Indigenous, and Global South population. This dissertation has three independent papers that explore the application of ecosystem-based adaptations, green infrastructures, and ecosystem services in communities unheard by environmental planning agencies. The first paper is a conceptual framework that used literature review and observations of current human-nature interactions to reflect how the criminalization, acculturation, and cultural appropriation of cultural ecosystem services have burdened Black and Indigenous identities. Recommendations for …

Energetic Tradeoffs, Infection, And Immunity In Wild Chimpanzees Of Uganda And Tanzania, Sarah Renee Phillips

Anthropology ETDs

Infectious disease is a primary source of mortality for most mammal species, but scientists have little understanding of factors driving variation in infection and immunity between individuals, populations, and species in the wild. Life history theory provides an evolutionary framework for delineating distribution of available energy to competing physiological demands, including growth, reproduction, and maintenance. Early life reproduction should be favored over late life survival, but, in long-lived species, reproductive success is strongly tied to survival to old age. Slower pace of reproduction could allow investment in immunity, reducing risk of morbidity and mortality to infectious disease. Additionally, several host …

Regulation Of P53 And Cancer Signaling By Heat Shock Protein 40/J-Domain Protein Family Members., Atsushi Kaida, Tomoo Iwakuma

Manuscripts, Articles, Book Chapters and Other Papers

Heat shock proteins (HSPs) are molecular chaperones that assist diverse cellular activities including protein folding, intracellular transportation, assembly or disassembly of protein complexes, and stabilization or degradation of misfolded or aggregated proteins. HSP40, also known as J-domain proteins (JDPs), is the largest family with over fifty members and contains highly conserved J domains responsible for binding to HSP70 and stimulation of the ATPase activity as a co-chaperone. Tumor suppressor p53 (p53), the most frequently mutated gene in human cancers, is one of the proteins that functionally interact with HSP40/JDPs. The majority of p53 mutations are missense mutations, resulting in acquirement …

Molecular Mechanisms Of Aberrant Protein Glycosylation In Pancreatic Cancer Stemness And Metastasis, Frank Leon

Theses & Dissertations

A myriad of genetic and other abnormal changes underlies the aggressiveness and dissemination properties observed in pancreatic cancer (PC). Aberrant protein glycosylation is a commonly observed feature in PC. The modification of protein O-glycosylation is mediated by glycosyltransferases, which attach and sequentially elongate monosaccharides on Serine/Threonine (Ser/Thr) motifs. Aberrant glycosylation is recognized as an emerging hallmark of cancer where a disruption in normal glycosylation results in irregular O-glycans.

This dissertation research has investigated the consequences of aberrant protein glycosylation on stemness and enhancement of metastatic properties in pancreatic ductal adenocarcinoma (PDAC). Several publications have reported aberrant O-glycosylation increases in oncogenic …

Risk Factors For Poor Outcomes Among Patients With Extensively Drug-Resistant Tuberculosis (Xdr-Tb): A Scoping Review, Karan Varshney, Beverly Anaele, Matthew Molaei, Rosemary Frasso, Vittorio Maio

College of Population Health Faculty Papers

In recent years, there has been an upsurge in cases of drug-resistant TB, and strains of TB resistant to all forms of treatment have begun to emerge; the highest level of resistance is classified as extensively drug-resistant tuberculosis (XDR-TB). There is an urgent need to prevent poor outcomes (death/default/failed treatment) of XDR-TB, and knowing the risk factors can inform such efforts. The objective of this scoping review was to therefore identify risk factors for poor outcomes among XDR-TB patients. We searched three scientific databases, PubMed, Scopus, and ProQuest, and identified 25 articles that examined relevant risk factors. Across the included …

Pollinators On Green Roofs: Diversity And Trait Analysis Of Wild Bees (Hymenoptera: Anthophila) And Hoverflies (Diptera: Syrphidae) In An Urban Area (Geneva, Switzerland), Aurelia Passaseo, Sophie Rochefort, Gaël Pétremand, Emmanuel Castella

Cities and the Environment (CATE)

Green roofs can provide food resources to several insect groups. For pollinators found in cities, as are wild bees and hoverflies, the existence of a wide variety of green infrastructures is crucial to ensure their development and survival. In order to investigate if wild bees and hoverflies use green roofs and how local and landscape factors influence their abundance and diversity, sampling of these insects was done in 2017 using cornet traps on extensive green roofs of two types: 1) urban green roofs (30% of green spaces in a 200m radius). There were 62 wild bee species and 10 hoverfly …

Civic Environmental Stewardship: Aligning Organizational And Participant Motivations, Kathleen L. Wolf, Weston Brinkley, Dale J. Blahna

Cities and the Environment (CATE)

Natural area management and sustainability in cities is ever more reliant on civic environmental stewardship. Many conservation organizations sponsor stewardship programs that enlist volunteers to care for the land and restore urban ecosystems. Stewardship program success depends on alignment of individuals’ and sponsoring organizations’ goals. We conducted surveys with a sample of 165 volunteers across natural areas stewardship events in metropolitan King County (Washington, U.S.). An adapted Volunteer Functions Inventory framework was used to understand volunteers’ motivations, satisfactions, and volunteering history. Our findings confirmed the multidimensional dynamics of volunteerism, as stewardship volunteers were motivated and expressed satisfaction for practical altruism, …

A New Criterion For Fluoroquinolone-Associated Disability Diagnosis: Functional Gastrointestinal Disorders, Deanna N. Cannizzaro, Lydia F. Naughton, Maya Z. Freeman, Linda Martin, Charles L. Bennett M.D., Ph.D., Cecilia Bove

Faculty Publications

Background and Objectives: Fluoroquinolones (FQs) are a broad-spectrum class of antibiotics routinely prescribed for common bacterial infections despite recent recommendations to use them only for life-threatening cases. In addition to their antimicrobial properties, FQs act in the central nervous system as GABAA receptor inhibitors, which could potentially affect functionality of the vagus nerve at the forefront of gastrointestinal (GI) tract function. Alterations in neural control of digestion have been shown to be linked to Functional Gastrointestinal Disorders (FGIDs), which are usually diagnosed based on self-reported symptoms. The aim of this study was to assess the incidence of FGIDs following FQ …

Stimming Expresses Empathy, Not To Be Masked Or Persecuted: A Scoping Review And Case Study Of The “Double-Empathy Problem” Solved By Recognizing The Autism Language, Kathryn Haas

Student Capstone Papers

This article critically examines autism and autistic stimming through the lenses of neurotypicals and autistics, evaluates confines currently imposed upon autistics by neurotypical society, and synthesizes what autistic leaders have expressed about their experiences striving for inclusion (Gernsbacher, 2017; Milton, 2012). Autistic-led studies are now at the forefront of the neurodiversity movement and are growing in fervor. The following themes were identified: (a) prevalence of autism, (b) the interpretation and measurement of empathy, (c) discovery of genetic factors transformed autistics’ identity, (d) publication of non-genetic factors such as vaccines undermined the legitimacy of the autism language, (e) the problem with …

Salt Marshes As Groundwater Buffers For Development: A Survey Of South Carolina Salt Marsh Basins, Alicia M. Wilson, Meghan Shanahan, Erik M. Smith

Faculty Publications

Salt marshes serve as zones of intense groundwater mixing and reaction between freshwater uplands and estuaries. This raises the question of whether the impacts of upland development on nutrient and carbon species can be transmitted through salt marshes via groundwater, or whether salt marshes can buffer estuarine waters from coastal development. We sampled groundwater from fifteen tidal creek basins in South Carolina to test for compositional differences associated with development and marsh width. Groundwater samples from near creekbanks and below freshwater uplands were analyzed for salinity, total dissolved nitrogen and phosphorus, and dissolved organic carbon. Analyses revealed significantly higher TDN …

Exploring The Biofilm Of Candida Auris As It Relates To Persistence In Clinical Setting And Susceptibility To Antimicrobials, Bethany Butts

Master of Science in Integrative Biology Theses

The rapid rise of drug-resistant pathogens is a global health concern. Known pathogens are acquiring resistance to many commonly used drugs, while new drug-resistant pathogens are emerging. These resistant pathogens are responsible for many healthcare-associated infections (HAI) [1, 2]. Candida auris is among these emerging drug-resistant pathogens, first described in 2009. The CDC labels C. auris at the highest level of global public health threat [3,4]. Effective methods of decolonization and control of the organisms have yet to be established, as it is resistant to many agents used for microbial control. Recent research has found that C. auris has the …

Impacts Of Social-Emotional Learning Via A Daily Writing Reflection In The Secondary Classroom, Angie Peterson

Dissertations, Theses, and Projects

The purpose of this qualitative study was to determine a time effective and subject area friendly way to address students’ social-emotional needs as a means to alleviate stress, communicate with teachers, and improve their overall wellbeing. Since the beginning of the COVID-19 pandemic, there have been many unforeseen or unaddressed repercussions that educators will continue to be dealing with as schools return to traditional formats or as they adjust to new ones. What impact can the use of daily journal writing have for high school students as an immediate and potentially long-term social-emotional learning or competency technique?

This study was …

Comparing Macroinvertebrate Total Abundance And Total Biomass On Five Substrate Types From Upstream To Downstream On The North Branch Of The Au Sable River, Paul David Dingman

Masters Theses

The North Branch of the Au Sable River is located in the northern lower peninsula of Michigan and is known for prolific hatches of Ephemeroptera (mayflies), Trichoptera (caddisflies), and Plecoptera (stoneflies). Macroinvertebrates play an important role in processing and recycling organic material in rivers and are a valuable food source for trout. In 2018, anglers were reporting catching fewer numbers of brook and brown trout (Salmo trutta and Salvelinus fontinalis). The Michigan Department of Natural Resources (MDNR) determined significantly lower abundance than the historical average. We hypothesized that trout abundances were lower due to a lack of prey …

Phage Commander, An Application For Rapid Gene Identification In Bacteriophage Genomes Using Multiple Programs, Matt Lazeriff, Geordie Ryder, Sarah L. Harris, Philippos K. Tsourkas

Computer Science Faculty Research

The number of sequenced bacteriophage genomes is growing at an exponential rate. The majority of sequenced bacteriophage genomes are annotated by one or more of several freely available gene identification programs (Glimmer, GeneMark, RAST, Prodigal, etc.). No program has been shown to consistently outperform the others; thus, the choice of which program to use is not obvious. We present the Phage Commander application for rapid identification of bacteriophage genes using multiple gene identification programs. Phage Commander runs a bacteriophage genome sequence through nine gene identification programs (and an additional program for identification of tRNAs) and integrates the results within a …

Female Puma (Puma Concolor) Highway Crossings In The Yucatan Peninsula, Carlos A. López González, Fernanda Cruz Torres, Mircea G. Hidalgo Mihart

Western North American Naturalist

Human infrastructure, particularly highway infrastructure, has proven to be a hazard for the resilience of large felid populations throughout the world. The Yucatan Peninsula is no exception and is presently confronted with the establishment of the “Tren Maya,” a continental railway that will reshape the road network of the peninsula. We describe 12 successful crossings of a 4-lane highway on the peninsula by a female puma (Puma concolor) fitted with a GPS radio-transmitter. The median time between sequential locations was 24 h (range 8–56 h), and the average number of days between crossings was 4.33 (SD = 2.50). …

Identifikasi Molekuler Dan Uji Aktivitas Inhibitor Alfa Glukosidase Dari Bakteri Endofit Daun Afrika (Vernonia Amygdalina), Siti Nurfajriah, Maulin Inggraini, Noor Andryan Ilsan

Chimica et Natura Acta

Diabetes Mellitus (DM) adalah penyakit gangguan metabolik yang ditandai dengan tingginya kadar glukosa darah postprandial atau hiperglikemia. Hal ini disebabkan oleh sel ß pankreas tidak dapat menghasilkan insulin yang cukup atau tubuh tidak dapat menggunakan insulin yang dihasilkan secara efektif. Pengendalian hiperglikemia merupakan hal penting dalam terapi pengobatan DM tipe 2. Salah satu caranya yaitu memberikan terapi inhibitor alfa glukosidase. Daun afrika (Vernonia amygdalina) merupakan tanaman yang berpotensi sebagai penghasil senyawa inhibitor alfa glukosidase. Penelitian ini bertujuan untuk mengisolasi dan menguji aktivitas inhibitor alfa glukosidase dari bakteri endofit daun afrika (Vernonia amygdalina) serta identifikasi molekuler bakteri yang menghasilkan inhibitor alfa …

Phase 3 Safety And Efficacy Of Azd1222 (Chadox1 Ncov-19) Covid-19 Vaccine, Ann R Falsey, Magdalena E Sobieszczyk, Ian Hirsch, Stephanie Sproule, Merlin L Robb, Lawrence Corey, Kathleen M Neuzil, William Hahn, Julie Hunt, Mark J Mulligan, Charlene Mcevoy, Edwin Dejesus, Michael Hassman, Susan J Little, Barbara A Pahud, Anna Durbin, Paul Pickrell, Eric S Daar, Larry Bush, Joel Solis, Quito Osuna Carr, Temitope Oyedele, Susan Buchbinder, Jessica Cowden, Sergio L Vargas, Alfredo Guerreros Benavides, Robert Call, Michael C Keefer, Beth D Kirkpatrick, John Pullman, Tina Tong, Margaret Brewinski Isaacs, David Benkeser, Holly E Janes, Martha C Nason, Justin A Green, Elizabeth J Kelly, Jill Maaske, Nancy Mueller, Kathryn Shoemaker, Therese Takas, Richard P Marshall, Menelas N Pangalos, Tonya Villafana, Antonio Gonzalez-Lopez

Faculty, Staff and Student Publications

BACKGROUND: The safety and efficacy of the AZD1222 (ChAdOx1 nCoV-19) vaccine in a large, diverse population at increased risk for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in the United States, Chile, and Peru has not been known.

METHODS: In this ongoing, double-blind, randomized, placebo-controlled, phase 3 clinical trial, we investigated the safety, vaccine efficacy, and immunogenicity of two doses of AZD1222 as compared with placebo in preventing the onset of symptomatic and severe coronavirus disease 2019 (Covid-19) 15 days or more after the second dose in adults, including older adults, in the United States, Chile, and Peru.

RESULTS: …

Restricted Microbial Presence, Activity, And Community Structuring Within Dry Valley Soils Of Antarctica, Scott Fillerup George

Theses and Dissertations

The McMurdo Dry Valley region is the largest ice-free area of Antarctica. Harsh abiotic conditions of the polar desert ecosystem, including extreme cold, aridity, and limited nutrient availability select for unique taxa. The comparatively simple terrestrial ecosystem is well-suited for investigating edaphic influences on microbial presence, activity, and community structuring. The Dry Valleys are viewed as a useful analog for Mars astrobiology investigations. However, most biotic investigations have been focused on lower elevations, where an understanding of edaphic effects on microbial communities within its generally more favorable conditions has emerged. Transiently wetted Dry Valley water tracks may be analogous to …

Antipsychotic Medication Administration In Oregon Assisted Living/Residential Care Settings: Analyzing An Action Situation, Sarah Dys

Dissertations and Theses

Antipsychotic medication use (APU) in assisted living and residential care (AL/RC) settings is an under-studied and controversial health policy issue. APU in older adults with dementia is associated with an increased risk of falls, hospitalizations, and early mortality. I operationalize the Institutional Analysis and Development Framework using a situational analysis approach, an extension of grounded theory methods, to explore the APU in Oregon AL/RC settings. Regulatory deficiency citations, Oregon AL/RC population data, and semi-structured interviews suggest that staff role clarity, organizational characteristics, and perceived agency influence decision-making around APU. AL/RC providers and caregivers are forced to simultaneously balance and prioritize …

Emotional Intelligence And Resonant Leadership: Investigating School Principals' Preparation And Professional Development In Response To Covid-19 And Other Challenges, Ashlie Kaye Miller

Dissertations and Theses

Research has shown that high levels of emotional intelligence and resonant leadership can reduce workplace stress and increase the health, wellness, satisfaction, and performance of employees. Many K-12 principals face a myriad of challenges that tend to produce chronic stress, including the recent Covid-19 pandemic. Yet, it is unclear how the preparation and professional development (PPD) programs available to principals incorporate and encourage resonant leadership practices that are needed to effectively cope with these challenges. This study used an explanatory sequential mixed methods design to examine the perceptions of K-12 principals in Oregon regarding: (a) their needs and challenges, especially …

Synthetic Aperture Optical Imaging Interferometric Microscopy With Improved Image Quality, Preyom K. Dey

Electrical and Computer Engineering ETDs

The resolution limit of optical microscopy can be extended by using Imaging Interferometric Microscopy (IIM), which uses a low numerical aperture (NA) objective lens to achieve resolution equivalent to that of a high-NA objective lens with multiple sub-images. Along with the resolution enhancement challenge, IIM often suffers from poor image quality. In this dissertation, several image quality improvement methods are proposed and verified with simulation and experimental results. Next, techniques to extend the resolution limit of IIM to ≤ 100nm using a low-NA objective lens are demonstrated. An experimental technique of using a grating coupler on …

Climate Mitigation Through Biological Conservation: Extensive And Valuable Blue Carbon Natural Capital In Tristan Da Cunha’S Giant Marine Protected Zone, David K.A. Barnes, James B. Bell, Amelia E. Bridges, Louise Ireland, Kerry L. Howell, Stephanie M. Martin, Chester J. Sands, Soto A Mora, Terri Souster, Gareth Flint, Simon A. Morley

School of Biological and Marine Sciences

Carbon-rich habitats can provide powerful climate mitigation if meaningful protection is put in place. We attempted to quantify this around the Tristan da Cunha archipelago Marine Protected Area. Its shallows (<1000 m depth) are varied and productive. The 5.4 km2 of kelp stores ~60 tonnes of carbon (tC) and may export ~240 tC into surrounding depths. In deep-waters we analysed seabed data collected from three research cruises, including seabed mapping, camera imagery, seabed oceanography and benthic samples from mini-Agassiz trawl. Rich biological assemblages on seamounts significantly differed to the islands and carbon storage had complex drivers. We estimate ~2.3 million tC are stored in benthic biodiversity of waters <1000 m, which includes >0.22 million tC that can be sequestered (the proportion of the carbon captured that is expected to become buried in sediment or locked away in skeletal tissue for at least 100 years). Much of this carbon is captured by cold-water coral reefs as a mixture of inorganic (largely calcium carbonate) and organic compounds. As part of its 2020 Marine Protection Strategy, these deep-water reef systems are now protected by …

Introduction To Symposium On Birth Rights And Wrongs, By Dov Fox, Peter Schuck

The Journal of Contemporary Legal Issues

This symposium consists of four essays by leading academic commentators developing their distinctive takes on the book, followed by a conclusion by Professor Fox containing detailed responses to each of them. This introduction provides a very brief, largely descriptive tour d’horizon of the commentators’ essays.

Birth Rights And Wrongs Extended, Reuven Brandt

The Journal of Contemporary Legal Issues

Dov Fox’s Birth Rights and Wrongs offers a largely compelling argument for expanding the scope of legal actions and remedies available to those whose reproductive choices are wrongfully frustrated by the actions of others. The dominant focus of the book is individuals who, due to the negligence and/‌or malice of medical professionals, suffer harms arising from reproduction imposed, denied, or confounded. A serious examination of these kinds of injuries is certainly appropriate given that medical professionals are increasingly involved in individuals’ reproductive plans and that serious harms may arise when desired medical interventions are improperly implemented. I will not take …

Birth Rights And Birth Wrongs Through A Common Law Lens: Why The No Liability Regime Is Likely To Endure, Richard A. Epstein

The Journal of Contemporary Legal Issues

Dov Fox’s recent book, the aptly named Birth Rights and Wrongs, is, as its title suggests, a study of the stark conflicts that arise in the highly contested area of reproductive rights. Fox makes the powerful case that the legal protection of reproductive rights, in all their protean forms, is systematically under-protected relative to two key benchmarks: the standards of ordinary decency, and social expectations. In my view, he has an acute awareness of these failures. But his greatest strength is also his greatest weakness, as he systematically ignores the great successes wrought through the current system, as disjointed …

Family Planning And Its Limits, Dov Fox

The Journal of Contemporary Legal Issues

A doctor botches a vasectomy. Or says it’d be dangerous to keep a healthy pregnancy. Or misses a risk of passing along disease. Our laws do little to deter such reproductive negligence or compensate its victims. Some of this misconduct leaves people without the baby they desperately want. Other times, it foists on parents a child they’d set out to avoid. Or one with meaningfully different traits than what they were led to believe.

I call these three harms procreation deprived, procreation imposed, and procreation confounded.

Thousands of fertility patients were deprived of biological parenthood when their …