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Lumos - Low And Intermediate Grade Glioma Umbrella Study Of Molecular Guided Therapies At Relapse: Protocol For A Pilot Study., Benjamin Y Kong, Hao-Wen Sim, Anna K Nowak, Sonia Yip, Elizabeth H Barnes, Bryan W Day, Michael E Buckland, Roel G W Verhaak, Terrance Johns, Cleo Robinson, Marc A Thomas, Tindaro Giardina, Zarnie Lwin, Andrew M Scott, Jonathon Parkinson, Rosalind Jeffree, Richard De Abreu Lourenco, Elizabeth J Hovey, Lawrence M Cher, Ganessan Kichendasse, Mustafa Khasraw, Merryn Hall, Emily Tu, Benhur Amanuel, Eng-Siew Koh, Hui K Gan

Faculty Research 2023

INTRODUCTION: Grades 2 and 3 gliomas (G2/3 gliomas), when combined, are the second largest group of malignant brain tumours in adults. The outcomes for G2/3 gliomas at progression approach the dismal outcomes for glioblastoma (GBM), yet there is a paucity of trials for Australian patients with relapsed G2/3 gliomas compared with patients with GBM. LUMOS will be a pilot umbrella study for patients with relapsed G2/3 gliomas that aims to match patients to targeted therapies based on molecular screening with contemporaneous tumour tissue. Participants in whom no actionable or no druggable mutation is found, or in whom the matching drug …

Ectodermal Dysplasia: A Review, Yasemin Yavuz, Mehmet Sinan Doğan, Myroslav Goncharuk-Khomyn

Makara Journal of Health Research

Background: Ectodermal dysplasia is a complex group of genetic disorders identified through the abnormal development of ectodermal structures. It is a genetic disorder that affects the development or functions of tissues such as the teeth, hair, nails, and sweat glands.

Methods: This review aimed to introduce the outcomes and increase awareness of ectodermal dysplasia reviewing by the literature.

Results: The characteristic features of this disease, including hypodontia, hypohidrosis, and hypotrichosis, have been discussed.

Conclusions: Ectodermal dysplasia is a heterogeneous group of hereditary disorders with similar clinical findings. It leads to the development of tissue malformations and …

Outcome Of Piercing Auricular Keloid After Surgical Excision By Through-And-Through Technique And Adjuvant Triamcinolone Acetonide Injection, Kollawat Jaruniphakul, Surajit Awsakulsutthi, Kornpong Kitvoraphat, Tirakorn Saengpongpithaya, Attawat Singnoo

Asian Medical Journal and Alternative Medicine

Introduction: Keloids are benign fibrous proliferative tissues resulting from pathological wound healing process. Auricular keloids are the challenging problem to cope with due to their resistanceto various modalities of treatment and having a high recurrence rate. There are no standard protocols for the treatment of ear keloids in the present practice. The purpose of this study is to introduce and evaluate the effectiveness of the practical treatment protocol for treating auricular keloids by using the modified surgical technique called “Through-and-Through excision technique” and postoperative intralesional TriamcinoloneAcetonide (TA) injection as an adjuvant therapy.

Methods: We retrospectively analyzed all patients who present …

The Effect Of Degradation On Biological Activity And Chemical Content Of Lom-Am-Ma-Preuk Extract, Krit Piwngam, Puritat Kanokkangsadal, Nantika Prommee, Kanmanee Sukkasem, Kalyarat Pumlek, Sunita Makchuchit, Neal M. Davies, Arunporn Itharat

Asian Medical Journal and Alternative Medicine

Introduction: Lom-Am-Ma-Preuk (LAP) remedy is a herbal remedy in Traditional Thai Medicine scripture and is on the National List of Essential Medicine in Thailand. Many herbal ingredients of LAP have significant inhibitory activity against the production of inflammatory mediators. The aim of this current study was to investigate forced degradation of extracts by heat, moisture, oxidation, and acid hydrolysis. The effects of these degradations were determined by anti-inflammatory activity and chemical content analysis of the LAP extract. The identified chemical markers including eugenol, myristicin, and piperine were compared amongst the remedies.

Methods: Antiinflammatory activity was determined by an inhibitory effect …

Risk Factors Associated With Outcomes Of Continuous Ambulatory Peritoneal Dialysis Survival: A Single-Center Study In A General Hospital, Supap Makruasi, Kitsarawut Khuancharee, Nisa Makruasi

Asian Medical Journal and Alternative Medicine

Introduction: Continuous ambulatory peritoneal dialysis (CAPD) has improved survival for renal replacement therapy in patients with end-stage renal disease (ESRD) in Thai patients. The benefit of CAPD in ESRD patients has been demonstrated in medical and quality of life. Nevertheless, the data of risk factors associated with CAPD mortality is dismal. Thus, this study aims to identify the factors associated with mortality of ESRD patients treated by CAPD modality.

Methods: A retrospective cohort study enrolled ESRD patients who had received CAPD in a general hospital in Nakhon Nayok, Thailand. Medical records including clinical characteristics, laboratory, and mortality outcomes were reviewed …

Removal Of Methylene Blue By Adsorption Of Water Hyacinth Derived Active Carbon Embedded With Cobalt Nanoparticles, Hany A. Elazab, A. O. Okasha, M. A. Radwan, M. A. Sadek, Amin Firouzi, Tamer T. El-Idreesy

Chemical and Biochemical Engineering Faculty Research & Creative Works

In this research, active carbon-based catalyst synthesis and characterization were tested for potential catalysts to be used in dye removal of methylene blue (MB). Water hyacinth is one of the major problems that is facing humankind and especially here in Egypt. One of the implications of industrial activities is environmental pollution. Dyes used in the production of textiles, paper, and clothes are one of the major pollutants. The waste of those dyes discharged into water supplies without treatment or with ineffective treatment harmfully impacts the environment. In this research, the treatment is implemented using active carbon-based catalysts using embedded nanoparticles. …

Psychological Birth Order And Achievement Goal Orientation Of High School Students Engaged In Shadow Education, Ryan Francis O. Cayubit, Nestlhyn B. Ligot, Jamie Therese T. Lim, Inah Karla R. Malaluan, Erika Mae U. Managbanag, Gretchen Hazelle D. Quindoza

Makara Human Behavior Studies in Asia

The focus of the current study is to examine the nature of the relationship of goal orientation with psychological birth order. Likewise, it also looked into the ability of psychological birth order to influence the endorsement of achievement goals (mastery-approach and avoidance; performance- approach and avoidance). A total of 220 high school students engaged in shadow education answered the White-Campbell Psychological Birth Order Inventory (PBOI) and the Achievement Goal Questionnaire (AGQ). Based on the regression analysis performed, only the pairing of psychological birth order and performance-approach is significant while those of psychological birth order, mastery-approach, mastery-avoidance, and performance-avoidance are not …

The Phenomena Of Dieng Plateau Tourismdestination Development Planning, Army Tunggu Hariwanto

Journal of Indonesian Tourism and Policy Studies

The tourism sector can be one of the mainstay sectors in the economic growth of the Dieng Plateau. One of the tourism problems in the Dieng Plateau is about accessibility and supporting infrastructure. Even though the existing road infrastructure is quite good, it can be improved again by widening the road access so that even large vehicles can easily cross it and needs to be improved also for other infrastructure such as hotels, restaurants, promotions, and others. The number of folklore or history in the Dieng area is the main factor to attract tourists and is also supported by beautiful …

A Portrait Of The Gender Gap In Stem: A Focus On Identity Formation Among Final-Year Undergraduate Students In Tanzania, Mjege Kinyota

Journal of Humanities and Social Sciences

This study investigates whether male and female students differ with respect to their STEM identity, and how female students negotiate between being female and being students pursuing careers that are perceived as masculine. The study uses a sequential explanatory mixed method design. A total of 749 final year STEM students from three Tanzanian universities participated in a survey that investigated STEM identity using six sub-scales: identity prominence, gender identity, stereotype endorsement, self-efficacy, persistence intentions, and positive feedback. Also, 19 females were interviewed as a follow-up exploration. Findings indicated a significant difference on stereotype endorsement only, where males significantly held negative …

Molecular Phylodiagnosis Of Taenia Hydatigena From Stray Dogs In Erbil Province-Kurdistan Region/Iraq, Zuber I. Hassan

Polytechnic Journal

Taenia hydatigena is one of the most prevalent taeniid species of livestock and dogs. A total of 52 fecal samples were collected from September 2019 to May 2020. The highest prevalence rate was observed in Rural area (21.15%, 11/52), as compared to Urban area (15.38%, 8/52). Nineteen (9 males and 10 females) out of 52 dogs were infected with T. hydatigena; there were no significant differences in prevalence based on molecular technique was observed between females (19.23%) and males (17.31%). The DNA’s of taeniid eggs were extracted, amplified, and sequenced by targeting of mitochondrial cytochrome c oxidase subunit 1 (cox1). …

Molecular Characterization Of Proteus Spp. From Patients Admitted To Hospitals In Erbil City, Treska Dh. Kamil, Sanaria F. Jarjes

Polytechnic Journal

The study was carried out to detect the identity of Proteus spp. isolated from various clinical specimens in Erbil City by polymerase chain reaction (PCR) technique. Specimens were of urine, wounds swabs, burn swabs, vaginal swabs, ear swabs, eye swabs, and sputum. Fifty-one Proteus isolates, (47) Proteus mirabilis, and (4) Proteus vulgaris, were undergone PCR assay using specific primers, targeting the genes ureR and Urease C (ureC), that encode for urease enzyme as a virulence factor of Proteus species. It was found that all isolates of Proteus mirabilis yielded positive result for ureR gene with an amplicon length of 225 …

Hypoglycemic And Hypolipidemic Potential Of Ginger-Thyme Combined Extract In Sucrose-Induced Hyperglycemic Rates, Burhan A. Salih, Dilzar S. Asaad

Polytechnic Journal

The current study is designed to investigate the in vivo action of ginger- thyme combined crude extract on hyperglycemia and obesity related measurements in sucrose induced chronic hyperglycemia experimental model in albino male rats. Twenty-five male albino rats were divided into five groups (N=5 for each); First group was regarded as control which consists of rats feed with normal diet and water ad libitum, while second group was the model which consists of rats fed with high sucrose fed (HSF) (50%sucrose). and other three groups were rats which treated with three different doses of ginger-thyme combination extract (125mg/kg, 250 mg/kg …

Maternal Mindful Eating As A Target For Improving Metabolic Outcomes In Pregnant Women With Obesity, Karen L. Lindsay, Jasper Most, Kerrie Buehler, Maryam Kebbe, Abby D. Altazan, Leanne M. Redman

Clinical Research Faculty Publications

Background: Maternal diet and eating behaviors have the potential to influence the metabolic milieu in pregnancies complicated by obesity, with implications for the developmental programming of offspring obesity. Emerging evidence suggests that mindfulness during eating may influence metabolic health in non-pregnant populations, but its effects in the context of pregnancy is less well understood. This study explored the individual and combined effects of mindful eating and diet quality on metabolic outcomes among pregnant women with obesity. Methods: In 46 pregnant women (body mas index >30 kg/m2) enrolled in the MomEE observational study, mindful eating (Mindful Eating Questionnaire, MEQ) and energy-adjusted …

Tribbles 2 Pseudokinase Confers Enzalutamide Resistance In Prostate Cancer By Promoting Lineage Plasticity, Jitender Monga, Indra Adrianto, Craig G. Rogers, Shirish M. Gadgeel, Dhananjay A. Chitale, Joshi J. Alumkal, Himisha Beltran, Amina Zoubeidi, Jagadananda Ghosh

Urology Articles

Enzalutamide, a second-generation antiandrogen, is commonly prescribed for the therapy of advanced prostate cancer, but enzalutamide-resistant, lethal, or incurable disease invariably develops. To understand the molecular mechanism(s) behind enzalutamide resistance, here, we comprehensively analyzed a range of prostate tumors and clinically relevant models by gene expression array, immunohistochemistry, and Western blot, which revealed that enzalutamide-resistant prostate cancer cells and tumors overexpress the pseudokinase, Tribbles 2 (TRIB2). Inhibition of TRIB2 decreases the viability of enzalutamide-resistant prostate cancer cells, suggesting a critical role of TRIB2 in these cells. Moreover, the overexpression of TRIB2 confers resistance in prostate cancer cells to clinically relevant …

Stress Classification Using Deep Learning With 1d Convolutional Neural Networks, Abdulrazak Yahya Saleh, Lau Khai Xian

Knowledge Engineering and Data Science

Stress has been a major problem impacting people in various ways, and it gets serious every day. Identifying whether someone is suffering from stress is crucial before it becomes a severe illness. Artificial Intelligence (AI) interprets external data, learns from such data, and uses the learning to achieve specific goals and tasks. Deep Learning (DL) has created an impact in the field of Artificial Intelligence as it can perform tasks with high accuracy. Therefore, the primary purpose of this paper is to evaluate the performance of 1D Convolutional Neural Networks (1D CNNs) for stress classification. A Psychophysiological stress (PS) dataset …

Single-Cell Analysis Of Aneurysmal Aortic Tissue In Patients With Marfan Syndrome Reveals Dysfunctional Tgf-Β Signaling, Ashley Dawson, Yanming Li, Yang Li, Pingping Ren, Hernan G. Vasquez, Chen Zhang, Kimberly R. Rebello, Waleed Ageedi, Alon R. Azares, Aladdein Burchett Mattar, Mary Burchett Sheppard, Hong S. Lu, Joseph S. Coselli, Lisa A. Cassis, Alan Daugherty, Ying H. Shen, Scott A. Lemaire

Saha Cardiovascular Research Center Faculty Publications

The molecular and cellular processes leading to aortic aneurysm development in Marfan syndrome (MFS) remain poorly understood. In this study, we examined the changes of aortic cell populations and gene expression in MFS by performing single-cell RNA sequencing (scRNA seq) on ascending aortic aneurysm tissues from patients with MFS (n = 3) and age-matched non-aneurysmal control tissues from cardiac donors and recipients (n = 4). The expression of key molecules was confirmed by immunostaining. We detected diverse populations of smooth muscle cells (SMCs), fibroblasts, and endothelial cells (ECs) in the aortic wall. Aortic tissues from MFS showed alterations …

The Mediating Role Of Interpersonal Relationship In The Effect Of Emotional Competence On Prosocial Behaviour Among Adolescents In Malaysia, Pit-Wan Pung, Doh Hian Koh, Soon Aun Tan, Ming Hui Yap

Makara Human Behavior Studies in Asia

Prosocial behaviour has been regarded as a necessity for a society to function well. The present study aimed to examine the relationship between emotional competence, interpersonal relationship and prosocial behaviour among 496 school-going adolescents in Malaysia. The subjects were selected using Multistage Cluster Sampling method. Profile of Emotional Competence (PEC), Inventory of Parent and Peer Attachment Scale (IPPA) and Strength and Difficulties Questionnaires (SDQ) were used to measure emotional competence, interpersonal relationship with peers and adolescents’ prosocial behaviour respectively. The results showed that there were significant positive relationships among emotional competence, interpersonal relationship with peers and prosocial behaviour. Further analysis …

Phenological And Social Characterization Of Three Lasioglossum (Dialictus) Species Inferred From Long-Term Trapping Collections, Lyllian A.-J. Corbin, David N. Awde, Miriam H. Richards

Entomology Faculty Publications

Detailed social and phenological data collected from nesting aggregations exist for relatively few sweat bee species because nesting aggregations are rarely found in large numbers, even when local populations are highly abundant. This limits researchers’ abilities to assess the social status of many species, which in turn, limits our ability to trace the sequence of evolutionary steps between alternative social states. To address this problem, we demonstrate the utility of rehydrated, pinned specimens from pan trap and netting collections for generating inferences about the phenology and social status of a well-studied sweat bee species, Lasioglossum (Dialictus) laevissimum. …

Capsaicinoids From Capsicum Annuum As An Alternative Fabh Inhibitor Of Mycobacterium Tuberculosis: In Silico Study, Gabriella Chandrakirana Krisnamurti, Dewi Ratih Tirto Sari, Yohanes Bare

Makara Journal of Science

The number of tuberculosis (TB) cases worldwide reached 1.5 million in 2018; thus, TB is considered a deadly disease. TB is caused by Mycobacterium tuberculosis and involves lipid synthesis. Considering the importance of lipid metabolism in bacteria, FabH may be an essential protein target for repressing lipid synthesis. Capsaicinoids from Capsicum annuum demonstrate potent antibacterial activity. This study predicted the ability of capsaicinoid compounds to inhibit FabH. In silico analysis was performed by retrieving the structure of FabH from PDB and those of selected capsaicinoid derivatives from PubChem. The compounds were docked using AutoDock Vina in PyRx 0.8 software. The …

Feeling Not Wanted/Loved And Depression: Does Gender Matter?, Manik Ahuja, Joy Okoro, Esther Frimpong, Riddhi P. Doshi, Rajvi J. Wani

ETSU Faculty Works

Depression affects over 17 million American adults yearly and has been identified as the leading cause of disability in people between the ages of 15 and 44 years. There is evidence that feeling neglect or a lack of parental attachment during childhood is associated with depression. One construct that has been overlooked is love from a parent. The purpose of this study was to analyze the association between individuals who felt not wanted/loved during adolescence and lifetime depression and to examine this association by gender. We examined 5114 participants aged 24–32 years at Wave IV of the National Longitudinal Study …

Evolution Or Revolution In Telehealth Regulation, George Horvath

Texas A&M Law Review

A frequently repeated adage, attributed to a wide range of authors and orators, holds that a serious crisis should never be allowed to go to waste. The moment in which we find ourselves renders this adage particularly timely. Responses to one of the defining crises of our age—the COVID–19 pandemic—have mostly been reactive. This includes the responses of multiple actors involved with telehealth. Congress, federal regulators, state legislatures, state regulators, private insurers, and health care providers, confronting the challenges of the pandemic, have responded by making ad hoc adjustments to the regulation and use of telehealth. Moving the conversation beyond …

The Allelopathic Potential Of Foliar Application Of Aqueous Extracts Of Chickpea On Growth And Yield Of Chickpea, Kawa A. Ali, Kawa K. Miran

Polytechnic Journal

A pot experiment was executed in the college of science, Salahaddin university glass house to investigate the allelopathic potentiality of aqueous chickpea Cicer arietinum L. seed extracts that was foliar sprayed on chickpea plants 45 days after sowing to estimate growth, yield, yield components, and seeds chemical characteristics. Results showed that the allelopathic effect was significant on chickpea plant height, number of pods per plant, seeds per pod, shoot dry weight, seed yield per plant, biological yield per plant, harvest index, hundred seeds weight, nitrogen, protein, and phosphorus content. The allelopathic effect was on its own species, and the effect …

Income Tax Incentives For Tourism Industry, Arie Widodo, Titin F. Nur

Journal of Indonesian Tourism and Policy Studies

The COVID-19 pandemic has resulted in the collapse of the economy in all sector and countries around the world. One of the sectors that experienced a major fall was the tourism sector. The government provide income tax facilities to stimulate domestic and foreign investment. The aim of this paper is to determine the government's policy that can be utilized by business actors in the tourism sector. This study uses qualitative research methods with library research. The results of this study indicate that the real estate sector in tourism industry is one that utilizes tax facilities. This paper recommends that other …

Growth Of (Platanus Orientalis L.) Seedlings Under Different Drought Stress Condition, Halmat A. Sabr

Polytechnic Journal

A lath house study was performed in order that understand the adjustment responses to three different water conditions of Platanus orientalis L. seedlings trying to make them able to adjust to new under dry conditions. Eight months seedlings were exposed to three water regimes (90, 60 and 30% water holding capacity [WHC]) were used r with a completely randomize design. The following parameters were measured; seedling height, leaf area, total chlorophyll content in the leaves, root length, root to shoot ratio, total dry mass, and leaf area ratio. It is found that water stress significantly reduced height and base diameter …

Effect Of Fenugreek Seeds In Maternal Diet On Some Features Of Newborn Pups In Albino Mice, Karim R. Hamad

Polytechnic Journal

Introduction: Fenugreek seeds have got interest of researchers for their positive effects on laboratory animals and human being, including their effects on reproductive system. The present study aimed to investigate the effects of 5% raw fenugreek seed and its boiled aqueous extract containing diet on adult female mice, for 2 weeks before mating, to evaluate fertility, and some features of newborn pups. Materials and Methods: A total of 90 adult female mice randomly and equally were divided into three groups. Group I: Control, Group II: Female mice treated with 5% raw fenugreek seed containing diet, and Group III: Female mice …

Parental Differences In Knowledge, Perception, And Safety Behaviors Regarding Home Injuries In An Urban Malaysian District, Munirah Mohd Basar, Mohd Fairuz Ali, Aznida Abdul Aziz

Makara Journal of Health Research

Background: Parents play an essential role in the prevention of home-related injuries among children. Traditionally, mothers provided direct overall care, whereas evidence on fathers' roles in children’s injuries is limited. This study assesses the differences between parents of children attending kindergarten regarding their knowledge and perception of home injuries and safety behaviors.

Methods: A cross-sectional study was conducted from January to April 2018 in 10 private kindergartens in the Selangor district in Malaysia. Self-administered questionnaires on sociodemographic data, knowledge of home injuries, perceptions toward home injuries, and safety behaviors at home were distributed. Descriptive and bivariate analyses were …

Evaluation Of Levofloxacin And Yahom-Navakot Remedy Extract Combination Therapy Against Antibiotic Resistant Bacteria In Vitro, Kitrawee Jiraratsatit, Sombat Muengtaweepongsa, Arunporn Itharat, Neal M. Davies

Asian Medical Journal and Alternative Medicine

Introduction: Antibiotic resistant bacteria are being considered a serious public health challenge. Levofloxacin is a broad-spectrum antibiotic, developed to replace previously resistant antimicrobials. The use of natural products as an antimicrobial drug is an alternative way to reduce bacterial resistance by synthesized drugs and enhance their efficacy. Yahom-Navakot (YN) is a Thai remedy in the Thai essential drug list. The indications for YN treatment are to relieve fatigue, dizziness, malaise, and vomiting after alleviation of fever. Previous studies have reported antibiotic enhancing effects of YN. This study was aimed to evaluate the antibacterial activities of levofloxacin and Yahom-Navakot Remedy Extract. …

Impact Of Motile Ciliopathies On Human Development And Clinical Consequences In The Newborn, Rachael Hyland, Steven L. Brody

Open Access Publications

No abstract provided.

Valuation Of Livestock In Farms, Piotr Kica, Piotr Szczypa

European Management Studies

Purpose: The aim of this article is to assess the possibility of applying the industry livestock valuation index as proposed by Karolina Pasula during the public defense of the doctoral dissertation “Directions and conditions for the standardization of accounting in agricultural enterprises” as an alternative method of valuation, taking into account sources of information and risk assessment on a farm. Methodology: The research process was divided into three main stages: (1) examining the possibility of applying the industry indicator for measuring biological assets proposed by K. Pasula for the valuation of livestock, i.e. pigs, as exemplified by a selected farm …

Characterization Of A New Whim Syndrome Mutant Reveals Mechanistic Differences In Regulation Of The Chemokine Receptor Cxcr4, Jiansong Luo, Francesco De Pascali, G Wendell Richmond, Amer M Khojah, Jeffrey L Benovic

Department of Biochemistry and Molecular Biology Faculty Papers

WHIM syndrome is a rare immunodeficiency disorder that is characterized by warts, hypogammaglobulinemia, infections, and myelokathexis. While several gain-of-function mutations that lead to C-terminal truncations, frame shifts and point mutations in the chemokine receptor CXCR4 have been identified in WHIM syndrome patients, the functional effect of these mutations are not fully understood. Here, we report on a new WHIM syndrome mutation that results in a frame shift within the codon for Ser339 (S339fs5) and compare the properties of S339fs5 with wild-type CXCR4 and a previously identified WHIM syndrome mutant, R334X. The S339fs5 and R334X mutants exhibited significantly increased signaling compared …