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Insights Into Nervous System Repair From The Fruit Fly, David Coupe, Torsten Bossing Jan 2022

Insights Into Nervous System Repair From The Fruit Fly, David Coupe, Torsten Bossing

Peninsula Medical School

Abstract Millions of people experience injury to the central nervous system (CNS) each year, many of whom are left permanently disabled, providing a challenging hurdle for the field of regenerative medicine. Repair of damage in the CNS occurs through a concerted effort of phagocytosis of debris, cell proliferation and differentiation to produce new neurons and glia, distal axon/dendrite degeneration, proximal axon/dendrite regeneration and axon re-enwrapment. In humans, regeneration is observed within the peripheral nervous system, while in the CNS injured axons exhibit limited ability to regenerate. This has also been described for the fruit fly Drosophila. Powerful genetic tools available …

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Organizational Perspectives On Outdoor Talking Therapy: Towards A Position Of ‘Environmental Safe Uncertainty’, Sam J. Cooley, Ceri R. Jones, Duncan Moss, Noelle Robertson Jan 2022

Organizational Perspectives On Outdoor Talking Therapy: Towards A Position Of ‘Environmental Safe Uncertainty’, Sam J. Cooley, Ceri R. Jones, Duncan Moss, Noelle Robertson

School of Psychology

No abstract provided.

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Effect Of Carbon Fibres On Electromagnetic-Interference-Shielding Properties Of Geopolymer Composites, Dimuthu Wanasinghe, Farhad Aslani, Guowei Ma Jan 2022

Effect Of Carbon Fibres On Electromagnetic-Interference-Shielding Properties Of Geopolymer Composites, Dimuthu Wanasinghe, Farhad Aslani, Guowei Ma

Research outputs 2022 to 2026

Many of the construction materials available are known to cause a drastic level of damage to the environment during their manufacturing stages. Hence, many researchers have attempted to formulate construction materials that are more environmentally friendly. Additionally, the rise in wireless communications in recent decades has seen a rapid increase in electromagnetic pollution and interference, which affects the functionality of sensitive electronic devices. This research is focused on fabricating a more sustainable construction material that could prevent electromagnetic interference for electronic devices housed inside. Carbon fibres of three different lengths were added in four variations to a geopolymer control mix …

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Consequences Of Thermal Plasticity For Hypoxic Performance In Coastal Amphipods, Michael Collins, Manuela Truebano, John I. Spicer Jan 2022

Consequences Of Thermal Plasticity For Hypoxic Performance In Coastal Amphipods, Michael Collins, Manuela Truebano, John I. Spicer

School of Biological and Marine Sciences

No abstract provided.

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Environmentally Friendly Agent Against Fall Armyworm (Spodoptera Frugiperda): Antifeedant Potency Of Mentha Spicata Aqueous Extracts, Emmanuel Peprah-Yamoah, Ebenezer Afrifa-Yamoah, Hayford Ofori, Eric Adua Jan 2022

Environmentally Friendly Agent Against Fall Armyworm (Spodoptera Frugiperda): Antifeedant Potency Of Mentha Spicata Aqueous Extracts, Emmanuel Peprah-Yamoah, Ebenezer Afrifa-Yamoah, Hayford Ofori, Eric Adua

Research outputs 2022 to 2026

The rising trends of insect resistance, coupled with escalating environmental pollution from synthetic pesticides, heighten the need for a more effective and, non-hazardous agents to control insect/pests. Different aqueous extracts of Mentha spicata were screened for their phytochemical constituents and their antifeedant activities against Spodoptera frugiperda. Screening of the different aqueous extracts of Mentha spicata obtained by cold maceration revealed the presence of phenolics and tannins. The concentration of phenols and tannins in the water, glycerine, and glycerine plus water (glycerine-water) extracts were significantly different (p < 0.05). Mentha spicata water extract had a greater antifeedant activity against Spodoptera frugiperda as compared to glycerine and glycerine-water (60 : 40, v/v) extracts at a concentration of 5g/100 mL. The estimated % antifeedant activity recorded were 97 as against 8.21 and 49.81, respectively. Aqueous neem seed water extracts gave an estimated % antifeedant activity of 93.07 and it served as a control. Saponins were absent in all extracts and only water extracts had alkaloids present. The simple, non-hazardous, and cost-saving extraction method demonstrated could be applied in both commercial and subsistent farming to counteract the damnable effects of Spodoptera frugiperda infestation.

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Perspectives On Wider Integration Of The Health-Assistive Smart Home, Gordana Dermody, Jenna Mikus, Davina Porock, Dov Sugarman, Naeem K. Janjua, Christopher How, Roschelle Fritz Jan 2022

Perspectives On Wider Integration Of The Health-Assistive Smart Home, Gordana Dermody, Jenna Mikus, Davina Porock, Dov Sugarman, Naeem K. Janjua, Christopher How, Roschelle Fritz

Research outputs 2022 to 2026

Most older adults desire to be as independent as possible and remain living in their ancestral home as they age. Aging-in-place maximizes the independence of older adults, enhancing their wellbeing and quality of life while decreasing the financial burden of residential care costs. However, due to chronic disease, multimorbidity, and age-related changes, appropriate conditions are required to make aging-in-place possible. Remote monitoring with smart home technologies could provide the infrastructure that enables older adults to remain living independently in their own homes safely. The health-assistive smart home shows great promise, but there are challenges to integrating smart homes on a …

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Deep Learning Inspired Feature Engineering For Classifying Tremor Severity, Ahmed Al Taee, Seyedehmarzieh Hosseini, Rami N. Khushaba, Tanveer Zia, Chin-Teng Lin, Adel Al-Jumaily Jan 2022

Deep Learning Inspired Feature Engineering For Classifying Tremor Severity, Ahmed Al Taee, Seyedehmarzieh Hosseini, Rami N. Khushaba, Tanveer Zia, Chin-Teng Lin, Adel Al-Jumaily

Research outputs 2022 to 2026

Bio-signals pattern recognition systems can be impacted by several factors with a potential to limit their associated performance and clinical translation. Among these factors, selecting the optimum feature extraction method, that can effectively exploit the interaction between the temporal and spatial information, is the most prominent. Despite the potential of deep learning (DL) models for extracting temporal, spatial, or temporal-spatial information, they are typically restricted by their need for a large amount of training data. The deep wavelet scattering transform (WST) is a relatively recent advancement within the DL literature to replace expensive convolution neural networks models with computationally less …

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Opicapone In Uk Clinical Practice: Effectiveness, Safety And Cost Analysis In Patients With Parkinson's Disease, Christine Schofield, K. Ray Chaudhuri, Camille Carroll, Jagdish C. Sharma, Nicola Pavese, Jonathan Evans, Thomas Foltynie, Heinz Reichmann, Laura Zurowska, Patrício Soares-Da-Silva, Andrew Lees Jan 2022

Opicapone In Uk Clinical Practice: Effectiveness, Safety And Cost Analysis In Patients With Parkinson's Disease, Christine Schofield, K. Ray Chaudhuri, Camille Carroll, Jagdish C. Sharma, Nicola Pavese, Jonathan Evans, Thomas Foltynie, Heinz Reichmann, Laura Zurowska, Patrício Soares-Da-Silva, Andrew Lees

Peninsula Medical School

Aim: This subanalysis of the OPTIPARK study aimed to confirm the effectiveness and safety of opicapone in patients with Parkinson's disease and motor fluctuations in clinical practice specifically in the UK and to assess the impact of opicapone on treatment costs. Methods: Patients received opicapone added to levodopa for 6 months. Clinical outcomes were assessed at 3 and 6 months and treatment costs at 6 months. Results: Most patients' general condition improved at 3 months, with sustained improvements reported at 6 months. Opicapone improved motor and non-motor symptoms at both timepoints, was generally well tolerated and reduced total treatment costs …

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Squat And Countermovement Jump Performance Across A Range Of Loads: A Comparison Between Smith Machine And Free Weight Execution Modes In Elite Sprinters, Irineu Loturco, Michael R. Mcguigan, Tomás T. Freitas, Fábio Y. Nakamura, Daniel A. Boullosa, Pedro L. Valenzuela, Lucas A. Pereira, Fernando Pareja-Blanco Jan 2022

Squat And Countermovement Jump Performance Across A Range Of Loads: A Comparison Between Smith Machine And Free Weight Execution Modes In Elite Sprinters, Irineu Loturco, Michael R. Mcguigan, Tomás T. Freitas, Fábio Y. Nakamura, Daniel A. Boullosa, Pedro L. Valenzuela, Lucas A. Pereira, Fernando Pareja-Blanco

Research outputs 2022 to 2026

The aims of this study were to: 1) provide and compare the height achieved during Smith machine (SM) and free weight (FW) loaded jumps executed over a wide spectrum of loads (40–120 % of body mass [BM]); and 2) test the difference between loaded and unloaded squat jump (SJ) and countermovement jump (CMJ) attempts in ten highly trained male sprinters. On the first visit, athletes performed unloaded SJ and CMJ, loaded SJ with loads corresponding to 40, 60, 80, 100, and 120 % BM, and loaded CMJ at 100% BM using an Olympic barbell (FW). On the second visit, they …

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Flexible Goal-Directed Manipulation Of Representations: Computational Models Of Healthy And Pathological Human Cognition, Giovanni Granato Jan 2022

Flexible Goal-Directed Manipulation Of Representations: Computational Models Of Healthy And Pathological Human Cognition, Giovanni Granato

School of Engineering, Computing and Mathematics Theses

The brain is able to manipulate itself, adapting its internal world in a changing environment. In particular it continuously manipulates its representations to achieve goals. This competence is supported by many neurocognitive high-order processes that interact during the performance of a goal-directed behaviour (e.g. attention processes, executive functions, motivational systems). Overall, adult humans often face a new problem trough a change of the `perceptual point of view' (i.e. a representational change), rather then an extended research of the correct action to perform. On the other hand, infants and children contemporary develop motor competence and task-directed perceptual representations (e.g. categorical perception). …

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Design Of Human Inspired Feet For Mithra, A High-Performance Humanoid Robot, Spencer Lyle Brewster Jan 2022

Design Of Human Inspired Feet For Mithra, A High-Performance Humanoid Robot, Spencer Lyle Brewster

Electronic Theses and Dissertations

This thesis explores the foot design for the new humanoid robot Mithra, with the goal to improve impact mitigation, natural gait throughout the gait cycle and balance. Using human gait parameters, a stiff aluminum foot was designed to emulate human center of pressure rollover trajectories. In addition, a 2D dynamic Finite Element Analysis (FEA) of the gait cycle was created in Abaqus to rapidly prototype foot designs. Data from the FE model provided impact forces, parameters for distal foot power evaluation and maximum lean angles. From this model a flexible nylon foot was optimized for the given design objectives. The …

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Hemocytes Are Essential For Drosophila Melanogaster Post-Embryonic Development, Independent Of Control Of The Microbiota, Holly N. Stephenson, Robert Streeck, Florian Grüblinger, Christian Goosmann, Alf Herzig Jan 2022

Hemocytes Are Essential For Drosophila Melanogaster Post-Embryonic Development, Independent Of Control Of The Microbiota, Holly N. Stephenson, Robert Streeck, Florian Grüblinger, Christian Goosmann, Alf Herzig

Peninsula Medical School

ABSTRACT Proven roles for hemocytes (blood cells) have expanded beyond the control of infections in Drosophila. Despite this, the crucial role of hemocytes in post-embryonic development has long thought to be limited to control of microorganisms during metamorphosis. This has previously been shown by rescue of adult development in hemocyte-ablation models under germ-free conditions. Here, we show that hemocytes have an essential role in post-embryonic development beyond their ability to control the microbiota. Using a newly generated strong hemocyte-specific driver line for the GAL4/UAS system, we show that specific ablation of hemocytes is early pupal lethal, even under axenic conditions. …

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Self-Management Intervention To Reduce Pulmonary Exacerbations By Supporting Treatment Adherence In Adults With Cystic Fibrosis: A Randomised Controlled Trial, Cfhealthhub Study Team, Martin J. Wildman, Alicia O’Cathain, Chin Maguire, Madelynne A. Arden, Marlene Hutchings, Judy Bradley, Stephen J. Walters, Pauline Whelan, John Ainsworth, Iain Buchan, Laura Mandefield, Laura Sutton, Paul Tappenden, Rachel A. Elliott, Zhe Hui Hoo, Sarah J. Drabble, Daniel Beever, H. Cantrill, J. Nicholl, S. Michie, S. Waterhouse, L. Robinson, A. Scott, S. Antrobus, E. Lumley, A. N. Biz, D. Hind, C. Orchard Jan 2022

Self-Management Intervention To Reduce Pulmonary Exacerbations By Supporting Treatment Adherence In Adults With Cystic Fibrosis: A Randomised Controlled Trial, Cfhealthhub Study Team, Martin J. Wildman, Alicia O’Cathain, Chin Maguire, Madelynne A. Arden, Marlene Hutchings, Judy Bradley, Stephen J. Walters, Pauline Whelan, John Ainsworth, Iain Buchan, Laura Mandefield, Laura Sutton, Paul Tappenden, Rachel A. Elliott, Zhe Hui Hoo, Sarah J. Drabble, Daniel Beever, H. Cantrill, J. Nicholl, S. Michie, S. Waterhouse, L. Robinson, A. Scott, S. Antrobus, E. Lumley, A. N. Biz, D. Hind, C. Orchard

Peninsula Medical School

Introduction Recurrent pulmonary exacerbations lead to progressive lung damage in cystic fibrosis (CF). Inhaled medications (mucoactive agents and antibiotics) help prevent exacerbations, but objectively measured adherence is low. We investigated whether a multi-component (complex) self-management intervention to support adherence would reduce exacerbation rates over 12 months. Methods Between October 2017 and May 2018, adults with CF (aged ≥16 years; 19 UK centres) were randomised to the intervention (data-logging nebulisers, a digital platform and behavioural change sessions with trained clinical interventionists) or usual care (data-logging nebulisers). Outcomes included pulmonary exacerbations (primary outcome), objectively measured adherence, body mass index (BMI), lung function …

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Graphene Based Electrochemical Biosensors For The Detection Of Blood Biomarkers Of Alzheimer’S Disease, Jagriti Sethi Jan 2022

Graphene Based Electrochemical Biosensors For The Detection Of Blood Biomarkers Of Alzheimer’S Disease, Jagriti Sethi

School of Engineering, Computing and Mathematics Theses

Alzheimer’s disease (AD) is a neurodegenerative disorder that affects millions of people around the world with no available treatments to cure, reverse or even slow down the disease progression. Detection of AD in the early stages, before the massive neuronal loss, is key to developing disease-modifying treatments and preventive strategies. The current AD diagnosis is largely based on evaluation tests such as Mini-Mental State Examination (MMSE), imaging techniques such as Magnetic Resonance Imaging (MRI), Positron Emission Tomography (PET), and postmortem autopsies. It is expensive and only available at the later/severe stages when the brain of the patient is already damaged …

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Cphelps Et Al. Disease, Natural And Aquaria E. Radiata Microbiome Asv (Amplicon Sequence Variant) Table, Charlie M. Phelps Jan 2022

Cphelps Et Al. Disease, Natural And Aquaria E. Radiata Microbiome Asv (Amplicon Sequence Variant) Table, Charlie M. Phelps

Research Datasets

This ASV table is the raw sequencing abundances for the Chapter 4 dataset with accompanying metadata.

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Bioaccumulation, Release And Genotoxicity Of Stainless Steel Particles In Marine Bivalve Molluscs, Emily L. Vernon, Awadhesh N. Jha, Maria F. Ferreira, Danielle L. Slomberg, Veronique Malard, Christian Grisolia, Mickaël Payet, Andrew Turner Jan 2022

Bioaccumulation, Release And Genotoxicity Of Stainless Steel Particles In Marine Bivalve Molluscs, Emily L. Vernon, Awadhesh N. Jha, Maria F. Ferreira, Danielle L. Slomberg, Veronique Malard, Christian Grisolia, Mickaël Payet, Andrew Turner

School of Biological and Marine Sciences

No abstract provided.

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European Epidemiological Patterns Of Cannabis- And Substance-Related Body Wall Congenital Anomalies: Geospatiotemporal And Causal Inferential Study, Albert Stuart Reece, Gary Kenneth Hulse Jan 2022

European Epidemiological Patterns Of Cannabis- And Substance-Related Body Wall Congenital Anomalies: Geospatiotemporal And Causal Inferential Study, Albert Stuart Reece, Gary Kenneth Hulse

Research outputs 2022 to 2026

As body wall congenital anomalies (BWCAs) have a long history of being associated with prenatal or community cannabis exposure (CCE), it was of interest to investigate these epidemiological relationships in Europe given the recent increases in cannabis use prevalence, daily intensity, and Δ9-tetrahydrocannabinol (THC) potency. Methods: This study makes use of BWCA data from Eurocat, drug exposure data from the European Monitoring Centre for Drugs and Drug Addiction, and income from the World Bank. Results: The mapping analysis showed that BWCARs increased in France, Spain, and the Netherlands. The bivariate mapping analysis showed that the BWCA rates (BWCAR) and the …

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Insights Into The Aerodynamic Versus Radiometric Surface Temperature Debate In Thermal-Based Evaporation Modeling, Kaniska Mallick, Dennis Baldocchi, Andrew Jarvis, Tian Hu, Ivonne Trebs, Mauro Sulis, Nishan Bhattarai, Christian Bossung, Yomna Eid, Jamie Cleverly, Jason Beringer, William Woodgate, Richard Silberstein, Nina Hinko-Najera, Wayne S. Meyer, Darren Ghent, Zoltan Szantoi, Gilles Boulet, William P. Kustas Jan 2022

Insights Into The Aerodynamic Versus Radiometric Surface Temperature Debate In Thermal-Based Evaporation Modeling, Kaniska Mallick, Dennis Baldocchi, Andrew Jarvis, Tian Hu, Ivonne Trebs, Mauro Sulis, Nishan Bhattarai, Christian Bossung, Yomna Eid, Jamie Cleverly, Jason Beringer, William Woodgate, Richard Silberstein, Nina Hinko-Najera, Wayne S. Meyer, Darren Ghent, Zoltan Szantoi, Gilles Boulet, William P. Kustas

Research outputs 2022 to 2026

Global evaporation monitoring from Earth observation thermal infrared satellite missions is historically challenged due to the unavailability of any direct measurements of aerodynamic temperature. State-of-the-art one-source evaporation models use remotely sensed radiometric surface temperature as a substitute for the aerodynamic temperature and apply empirical corrections to accommodate for their inequality. This introduces substantial uncertainty in operational drought mapping over complex landscapes. By employing a non-parametric model, we show that evaporation can be directly retrieved from thermal satellite data without the need of any empirical correction. Independent evaluation of evaporation in a broad spectrum of biome and aridity yielded statistically significant …

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Sinking Seaweed In The Deep Ocean For Carbon Neutrality Is Ahead Of Science And Beyond The Ethics, Aurora M. Ricart, Dorte Krause-Jensen, Kasper Hancke, Nichole N. Price, Pere Masqué, Carlos M. Duarte Jan 2022

Sinking Seaweed In The Deep Ocean For Carbon Neutrality Is Ahead Of Science And Beyond The Ethics, Aurora M. Ricart, Dorte Krause-Jensen, Kasper Hancke, Nichole N. Price, Pere Masqué, Carlos M. Duarte

Research outputs 2022 to 2026

Sinking vast amounts of seaweed in the deep ocean is currently being proposed as a promising ocean carbon dioxide removal strategy as well as a natural-based solution to mitigate climate change. Still, marketable carbon offsets through large-scale seaweed sinking in the deep ocean lack documentation and could involve unintended environmental and social consequences. Managing the risks requires a number of urgent actions.

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Voluntary Activation Of Muscle In Humans: Does Serotonergic Neuromodulation Matter?, Justin J. Kavanagh, Janet L. Taylor Jan 2022

Voluntary Activation Of Muscle In Humans: Does Serotonergic Neuromodulation Matter?, Justin J. Kavanagh, Janet L. Taylor

Research outputs 2022 to 2026

Ionotropic inputs to motoneurones have the capacity to depolarise and hyperpolarise the motoneurone, whereas neuromodulatory inputs control the state of excitability of the motoneurone. Intracellular recordings of motoneurones from in vitro and in situ animal preparations have provided extraordinary insight into the mechanisms that underpin how neuromodulators regulate neuronal excitability. However, far fewer studies have attempted to translate the findings from cellular and molecular studies into a human model. In this review, we focus on the role that serotonin (5-HT) plays in muscle activation in humans. 5-HT is a potent regulator of neuronal firing rates, which can influence the force …

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Why Do Men With Prostate Cancer Discontinue Active Surveillance For Definitive Treatment? A Mixed Methods Investigation, Megan Mcintosh, Melissa J. Opozda, Michael O’Callaghan, Andrew D. Vincent, Daniel A. Galvão, Camille E. Short Jan 2022

Why Do Men With Prostate Cancer Discontinue Active Surveillance For Definitive Treatment? A Mixed Methods Investigation, Megan Mcintosh, Melissa J. Opozda, Michael O’Callaghan, Andrew D. Vincent, Daniel A. Galvão, Camille E. Short

Research outputs 2022 to 2026

Objectives: To explore the personal and/or medical reasons patients on active surveillance (AS) have, or consider having, further definitive treatment for their prostate cancer. Research suggests up to 50% of patients on AS will discontinue within 5 years, though reasons for discontinuation from the patient's perspective is under-explored. Methods: Prostate cancer patients who were or had been on AS for at least 6 months were recruited. A questionnaire assessed reasons for receiving/considering definitive treatment and the extent to which reasons were personal or medical. Clinical information was extracted from a state-level population registry. A subset of participants were interviewed to …

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Mega-Analysis Methods In Enigma: The Experience Of The Generalized Anxiety Disorder Working Group, André Zugman, Jennifer Harper, Michael Myers, Michael T Perino, Qiongru Yu, Chad M Sylvester, Et Al. Jan 2022

Mega-Analysis Methods In Enigma: The Experience Of The Generalized Anxiety Disorder Working Group, André Zugman, Jennifer Harper, Michael Myers, Michael T Perino, Qiongru Yu, Chad M Sylvester, Et Al.

2020-Current year OA Pubs

The ENIGMA group on Generalized Anxiety Disorder (ENIGMA-Anxiety/GAD) is part of a broader effort to investigate anxiety disorders using imaging and genetic data across multiple sites worldwide. The group is actively conducting a mega-analysis of a large number of brain structural scans. In this process, the group was confronted with many methodological challenges related to study planning and implementation, between-country transfer of subject-level data, quality control of a considerable amount of imaging data, and choices related to statistical methods and efficient use of resources. This report summarizes the background information and rationale for the various methodological decisions, as well as …

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Show, Attend And Detect: Towards Fine-Grained Assessment Of Abdominal Aortic Calcification On Vertebral Fracture Assessment Scans, Syed Zulqarnain Gilani, Naeha Sharif, David Suter, John T. Schousboe, Siobhan Reid, William D. Leslie, Joshua R. Lewis Jan 2022

Show, Attend And Detect: Towards Fine-Grained Assessment Of Abdominal Aortic Calcification On Vertebral Fracture Assessment Scans, Syed Zulqarnain Gilani, Naeha Sharif, David Suter, John T. Schousboe, Siobhan Reid, William D. Leslie, Joshua R. Lewis

Research outputs 2022 to 2026

More than 55,000 people world-wide die from Cardiovascular Disease (CVD) each day. Calcification of the abdominal aorta is an established marker of asymptomatic CVD. It can be observed on scans taken for vertebral fracture assessment from Dual Energy X-ray Absorptiometry machines. Assessment of Abdominal Aortic Calcification (AAC) and timely intervention may help to reinforce public health messages around CVD risk factors and improve disease management, reducing the global health burden related to CVDs. Our research addresses this problem by proposing a novel and reliable framework for automated “fine-grained” assessment of AAC. Inspired by the vision-to-language models, our method performs sequential …

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A Myc-Znf148-Id1/3 Regulatory Axis Modulating Cancer Stem Cell Traits In Aggressive Breast Cancer, Mijeong Kim, Manjot Singh, Bum-Kyu Lee, Moira Hibbs, Kirsty Richardson, Lesley Ellies, Larissa Wintle, Lisa M. Stuart, Jenny Y. Wang, Dominic C. Voon, Pilar Blancafort, Jianlong Wang, Jonghwan Kim, Peter J. Leedman, Andrew J. Woo Jan 2022

A Myc-Znf148-Id1/3 Regulatory Axis Modulating Cancer Stem Cell Traits In Aggressive Breast Cancer, Mijeong Kim, Manjot Singh, Bum-Kyu Lee, Moira Hibbs, Kirsty Richardson, Lesley Ellies, Larissa Wintle, Lisa M. Stuart, Jenny Y. Wang, Dominic C. Voon, Pilar Blancafort, Jianlong Wang, Jonghwan Kim, Peter J. Leedman, Andrew J. Woo

Research outputs 2022 to 2026

The MYC proto-oncogene (MYC) is one of the most frequently overexpressed genes in breast cancer that drives cancer stem cell-like traits, resulting in aggressive disease progression and poor prognosis. In this study, we identified zinc finger transcription factor 148 (ZNF148, also called Zfp148 and ZBP-89) as a direct target of MYC. ZNF148 suppressed cell proliferation and migration and was transcriptionally repressed by MYC in breast cancer. Depletion of ZNF148 by short hairpin RNA (shRNA) and CRISPR/Cas9 increased triple-negative breast cancer (TNBC) cell proliferation and migration. Global transcriptome and chromatin occupancy analyses of ZNF148 revealed a central role in inhibiting cancer …

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The Impact Of Skeletal Muscle Disuse On Distinct Echo Intensity Bands: A Retrospective Analysis, Zachary S. Logeson, Rob J. Maclennan, Gerard Kyle B. Abad, Johnathon M. Methven, Molly R. Gradl, Matheus D. Pinto, Ronei S. Pinto, Matt S. Stock Jan 2022

The Impact Of Skeletal Muscle Disuse On Distinct Echo Intensity Bands: A Retrospective Analysis, Zachary S. Logeson, Rob J. Maclennan, Gerard Kyle B. Abad, Johnathon M. Methven, Molly R. Gradl, Matheus D. Pinto, Ronei S. Pinto, Matt S. Stock

Research outputs 2022 to 2026

Echo intensity (EI) is a novel tool for assessing muscle quality. EI has traditionally been reported as the mean of the pixel histogram, with 0 and 255 arbitrary units (A.U.) representing excellent and poor muscle quality, respectively. Recent work conducted in youth and younger and older adults suggested that analyzing specific EI bands, rather than the mean, may provide unique insights into the effectiveness of exercise and rehabilitation interventions. As our previous work showed deterioration of muscle quality after knee joint immobilization, we sought to investigate whether the increase in EI following disuse was limited to specific EI bands. Thirteen …

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Cgas-Sting Pathway Targeted Therapies And Their Applications In The Treatment Of High-Grade Glioma, Shashwat Tripathi, Hinda Najem, Akanksha Sanjay Mahajan, Peng Zhang, Justin T Low, Alexander H Stegh, Michael A Curran, David M Ashley, Charles David James, Amy B Heimberger Jan 2022

Cgas-Sting Pathway Targeted Therapies And Their Applications In The Treatment Of High-Grade Glioma, Shashwat Tripathi, Hinda Najem, Akanksha Sanjay Mahajan, Peng Zhang, Justin T Low, Alexander H Stegh, Michael A Curran, David M Ashley, Charles David James, Amy B Heimberger

2020-Current year OA Pubs

Median survival of patients with glioblastoma (GBM) treated with standard of care which consists of maximal safe resection of the contrast-enhancing portion of the tumor followed by radiation therapy with concomitant adjuvant temozolomide (TMZ) remains 15 months. The tumor microenvironment (TME) is known to contain immune suppressive myeloid cells with minimal effector T cell infiltration. Stimulator of interferon genes (STING) is an important activator of immune response and results in production of Type 1 interferon and antigen presentation by myeloid cells. This review will discuss important developments in STING agonists, potential biomarkers for STING response, and new combinatorial therapeutic approaches …

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Predicting Coronary Stenosis Progression Using Plaque Fatigue From Ivus-Based Thin-Slice Models: A Machine Learning Random Forest Approach, Xiaoya Guo, Akiko Maehara, Mingming Yang, Liang Wang, Jie Zheng, Habib Samady, Gary S Mintz, Don P Giddens, Dalin Tang Jan 2022

Predicting Coronary Stenosis Progression Using Plaque Fatigue From Ivus-Based Thin-Slice Models: A Machine Learning Random Forest Approach, Xiaoya Guo, Akiko Maehara, Mingming Yang, Liang Wang, Jie Zheng, Habib Samady, Gary S Mintz, Don P Giddens, Dalin Tang

2020-Current year OA Pubs

No abstract provided.

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Influenza: Toward Understanding The Immune Response In The Young, Sonia Sakleshpur, Ashley L Steed Jan 2022

Influenza: Toward Understanding The Immune Response In The Young, Sonia Sakleshpur, Ashley L Steed

2020-Current year OA Pubs

Annually influenza causes a global epidemic resulting in 290,000 to 650,000 deaths and extracts a massive toll on healthcare and the economy. Infants and children are more susceptible to infection and have more severe symptoms than adults likely mitigated by differences in their innate and adaptive immune responses. While it is unclear the exact mechanisms with which the young combat influenza, it is increasingly understood that their immune responses differ from adults. Specifically, underproduction of IFN-γ and IL-12 by the innate immune system likely hampers viral clearance while upregulation of IL-6 may create excessive damaging inflammation. The infant's adaptive immune …

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Cardiac Immune Cell Infiltration Associates With Abnormal Lipid Metabolism, Vincenza Cifarelli, Ondrej Kuda, Kui Yang, Xinping Liu, Richard W Gross, Terri A Pietka, Gyu Seong Heo, Deborah Sultan, Hannah Luehmann, Josie Lesser, Morgan Ross, Ira J Goldberg, Robert J Gropler, Yongjian Liu, Nada A Abumrad Jan 2022

Cardiac Immune Cell Infiltration Associates With Abnormal Lipid Metabolism, Vincenza Cifarelli, Ondrej Kuda, Kui Yang, Xinping Liu, Richard W Gross, Terri A Pietka, Gyu Seong Heo, Deborah Sultan, Hannah Luehmann, Josie Lesser, Morgan Ross, Ira J Goldberg, Robert J Gropler, Yongjian Liu, Nada A Abumrad

2020-Current year OA Pubs

CD36 mediates the uptake of long-chain fatty acids (FAs), a major energy substrate for the myocardium. Under excessive FA supply, CD36 can cause cardiac lipid accumulation and inflammation while its deletion reduces heart FA uptake and lipid content and increases glucose utilization. As a result, CD36 was proposed as a therapeutic target for obesity-associated heart disease. However, more recent reports have shown that CD36 deficiency suppresses myocardial flexibility in fuel preference between glucose and FAs, impairing tissue energy balance, while CD36 absence in tissue macrophages reduces efferocytosis and myocardial repair after injury. In line with the latter homeostatic functions, we …

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Understanding The Contribution Of Metabolism To Mycobacterium Tuberculosis Drug Tolerance, Amanda N Samuels, Erin R Wang, Gregory A Harrison, Joy C Valenta, Christina L Stallings Jan 2022

Understanding The Contribution Of Metabolism To Mycobacterium Tuberculosis Drug Tolerance, Amanda N Samuels, Erin R Wang, Gregory A Harrison, Joy C Valenta, Christina L Stallings

2020-Current year OA Pubs

Treatment of

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