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Unlocking The Genomic Regions Associated With Seed Protein Contents In Turkishcommon Bean Germplasm Through Genome-Wide Association Study, Faheem Shahzad Baloch, Muhammad Azhar Nadeem Jan 2022

Unlocking The Genomic Regions Associated With Seed Protein Contents In Turkishcommon Bean Germplasm Through Genome-Wide Association Study, Faheem Shahzad Baloch, Muhammad Azhar Nadeem

Turkish Journal of Agriculture and Forestry

Human body needs sufficient quantity of protein on daily basis for the normal functioning. Dietary protein in sufficient quantity is becoming a key issue for huge population of the world particularly in developing countries. Present investigation aimed to explore the phenotypic variation and to investigate the genomic regions associated with seed protein contents in Turkish common bean germplasm collected from 19 provinces. Field experiments were conducted according to augmented block design at two locations (Bolu and Sivas) for two consecutive years (2017 and 2018). Analysis of variance revealed highly significant environmental effects (p < 0.05) on seed protein contents within environments, while genotype by environment interaction revealed nonsignificant effects. Overall mean protein contents were 36.36%, while Balikesir-3 and Hakkari-38 yielded minimum (31.64%) and maximum (40.70%) protein contents. Among 19 provinces, accessions from Hakkari and Erzincan provinces disclosed maximum and minimum mean protein contents respectively. Scatter plot between seed protein contents and plant height divided the accessions according to their protein contents and plant height. A total of eight stable accessions were selected and can be recommended for future breeding activities. The implemented constellation plot separated the studied germplasm into two populations on the basis of their protein contents. Genotyping by sequencing resulted 7900 DArTseq markers was used for marker-trait association and a total of 11 markers showed significant association for protein contents. During this study, DArT-3365703 marker was identified in both locations (Sivas and Bolu) during 2017 and might be used for future common bean breeding. Physical map revealed the presence narrow regions between identified markers on Pv02 and Pv05. Therefore, these regions should be considered for future breeding activities. We are confident that results of present study will be helpful for marker-assisted breeding of common bean.


Research On The Potential Of Some Sweet Sorghum Genotypes As Bioethanol Source Undermediterranean Conditions, Celal Yücel, Derya Yücel, Rüştü Hati̇poğlu, Ismail Dweikat Jan 2022

Research On The Potential Of Some Sweet Sorghum Genotypes As Bioethanol Source Undermediterranean Conditions, Celal Yücel, Derya Yücel, Rüştü Hati̇poğlu, Ismail Dweikat

Turkish Journal of Agriculture and Forestry

Sweet sorghum (Sorghum bicolor var. saccharatum (L.) Mohlenbr.) is a variety of sorghum developed for the harvest of sweet juice, rather than grain. It has been identified as a potential ethanol feedstock crop for rainfed areas in different parts of the world. It is a promising source of bioenergy due to its high biomass, drought tolerance and low input. This study was conducted to determine the potential of bioethanol production from different sweet sorghum varieties under the Çukurova conditions with a Mediterranean climate. Experiments were conducted over two years in 2016 and 2017 on the experimental fields of the Eastern …


Induction Of Polyploidy In Grapevine (Vitis Vinifera L.) Seedlings By In Vivo Colchicineapplications, Zeki̇ Kara, Kevser Yazar Jan 2022

Induction Of Polyploidy In Grapevine (Vitis Vinifera L.) Seedlings By In Vivo Colchicineapplications, Zeki̇ Kara, Kevser Yazar

Turkish Journal of Agriculture and Forestry

Polyploidization is an important technique used in grape breeding to create new genetic resources and can be induced using some antimitotic agents, including colchicine. Plants with increased ploidy can gain better quality than their original diploids in some characteristics. In this study, which was carried out to obtain polyploid genotypes under in vivo conditions, the effects of six (1 g L-1, 2 g L-1, 3 g L-1, 4 g L-1, 5 g L-1, 6 g L-1) doses of colchicine were applied to the shoot tip meristem regions of the seedlings obtained from the seeds of grapevine cv. Ekşi Kara and …


Medicinal And Aromatic Plants In The Omics Era: Application Of Plant Breeding Andbiotechnology For Plant Secondary Metabolite Production, Muzaffer Barut, Muhammad Azhar Nadeem, Özlem Akgür, Leyla Sezen Tansi, Muhammad Aasim, Muhammad Tanveer Altaf, Faheem Shahzad Baloch Jan 2022

Medicinal And Aromatic Plants In The Omics Era: Application Of Plant Breeding Andbiotechnology For Plant Secondary Metabolite Production, Muzaffer Barut, Muhammad Azhar Nadeem, Özlem Akgür, Leyla Sezen Tansi, Muhammad Aasim, Muhammad Tanveer Altaf, Faheem Shahzad Baloch

Turkish Journal of Agriculture and Forestry

Human being has strong and historic connections with plants to fulfill food, feed, and shelter. Moreover, human uses plants as medicine for the treatment of various diseases. Plants are chemical factories for the biosynthesis of the huge number of secondary metabolites (SMs) that are directly used as a medicine or indirectly used in the development of commercial pharmaceutical drugs. Their improvement through classical breeding remains a difficult struggle for plant breeders. Hence, rapidly advancing research on the plant omics era has accelerated our understanding of the complex structure of SMs synthesis in medicinal and aromatic plants (MAPs). In addition, sequencing …


Morphological, Biochemical, And Bioactive Characterization Of Naturally Growneuropean Cranberrybush Genotypes, Ayşen Melda Çolak, Fatma Alan, Kerem Mertoğlu, İbrahi̇m Bulduk Jan 2022

Morphological, Biochemical, And Bioactive Characterization Of Naturally Growneuropean Cranberrybush Genotypes, Ayşen Melda Çolak, Fatma Alan, Kerem Mertoğlu, İbrahi̇m Bulduk

Turkish Journal of Agriculture and Forestry

Turkey has very rich potential in terms of wild edible fruit species, especially berries that grow naturally in different parts of the country as population or scattered shrubs. One of the most important wild edible fruits found in Turkey's flora is the European cranberrybush (EC). All EC plants are found as wild in nature and there are no commercial EC orchards in the country. In this study, a total of 22 seed propagated EC genotypes that naturally grown in the Akkışla district of Kayseri province located in the middle part of Turkey were assessed in terms of their morphological (fruit …


Inter-Primer Binding Site (Ipbs) Retrotransposon Markers Provide Insights Into Thegenetic Diversity And Population Structure Of Carrots (Daucus, Apiaceae), Mehtap Yildiz, Carlos Arbizu Jan 2022

Inter-Primer Binding Site (Ipbs) Retrotransposon Markers Provide Insights Into Thegenetic Diversity And Population Structure Of Carrots (Daucus, Apiaceae), Mehtap Yildiz, Carlos Arbizu

Turkish Journal of Agriculture and Forestry

Studies of genetic diversity and population structure are essential as an initial step in conservation and breeding programs for modern crops. Carrot (Daucus spp.) is among the ten most important vegetables worldwide, however, its genetic structure and phylogenetic relationships are not totally deciphered. Here, we explored the utility of 21 inter-primer binding site (iPBS) retrotransposon markers to determine the genetic diversity and population structure of 38 accessions of Daucus and one accession of a related genus. The manual scoring revealed 309 bands based on their presence/absence. The dendrogram based on the UPGMA clustering algorithm and a principal coordinate analysis (PCoA) …


Characterization Of Some Local Pea (Pisum Sativum L.) Genotypes For Agro-Morphologicaltraits And Mineral Concentrations, Aybegün Ton, Dürdane Mart, Tolga Karaköy, Meltem Türkeri̇, Ayfer Alkan Torun, Adem Emi̇n Anlarsal Jan 2022

Characterization Of Some Local Pea (Pisum Sativum L.) Genotypes For Agro-Morphologicaltraits And Mineral Concentrations, Aybegün Ton, Dürdane Mart, Tolga Karaköy, Meltem Türkeri̇, Ayfer Alkan Torun, Adem Emi̇n Anlarsal

Turkish Journal of Agriculture and Forestry

The aim of the present study is to evaluate diversity among the Turkish local pea germplasm for mineral concentrations and agro-morphological traits for breeding programs. The experiment was conducted during 2018/2019 and 2019/2020 and arranged according to an augmented block design with 40 local genotypes and two standard check cultivars (Carina and Jof). Seed yield per plant was positively and significantly correlated with branches per plant, pods per plant, seeds per pod, harvest index, and 100-seed weight. The first three principal components (PC1) for agro-morphological traits accounted for 76.3% of the total variation. The principal first component was positively correlated …


Cover And Contents Jan 2022

Cover And Contents

Turkish Journal of Agriculture and Forestry

No abstract provided.


Characterization Of Arbuscular Mycorrhizal Fungal Communities Associated Withvineyards In Northwestern Iran, Younes Rezaee Danesh, Khalil Kariman, Nurhan Keski̇n, Solmaz Najafi Jan 2022

Characterization Of Arbuscular Mycorrhizal Fungal Communities Associated Withvineyards In Northwestern Iran, Younes Rezaee Danesh, Khalil Kariman, Nurhan Keski̇n, Solmaz Najafi

Turkish Journal of Agriculture and Forestry

Arbuscular mycorrhizal fungi (AMF) establish beneficial symbiotic associations with plants, enhancing their nutrient uptake, growth, and stress tolerance. The present study was aimed to investigate AMF spore density, species composition, mycorrhizal colonization patterns, and correlation of these indices with soil physicochemical parameters at four vineyards located in one of the most important grape-producing regions of Iran (West Azerbaijan province). Forty-three soil samples were collected from four grapeproducing regions during July-August 2019. The total spore abundance ranged from 39-647 spores per 100 g dry soil. Twelve AMF species, representing six genera (Rhizophagus, Funneliformis, Glomus, Septoglomus, Claroideoglomus, and Scutellospora) were identified. Rhizophagus …


Efficacy Of A Newly Developed Seed Coating Formulation For The Control Of Seed-Bornediseases, Meriam Bouri, Zeynep İyi̇gündoğdu, Pinar Lök, Fi̇kretti̇n Şahi̇n Jan 2022

Efficacy Of A Newly Developed Seed Coating Formulation For The Control Of Seed-Bornediseases, Meriam Bouri, Zeynep İyi̇gündoğdu, Pinar Lök, Fi̇kretti̇n Şahi̇n

Turkish Journal of Agriculture and Forestry

Seed coating is receiving increased relevance in sustainable agriculture, to reduce the usage of pesticides and protect the natural environment. In this study, a new formulation based on the combination of two active constituents (zinc pyrithione and triclosan) and an inactive component (carboxymethyl cellulose polymer) was optimized for seed coating to control seed-borne pathogens. According to the in vitro antimicrobial tests, the combination of zinc pyrithione and triclosan showed a broader spectrum of phytopathogenic bacteria and fungi control. Coated seeds from different plant species with 2% of zinc pyrithione, 0.05% of triclosan and, 0.5% of carboxymethyl cellulose did not show …


Study Of Anatomical And Acc (1-Aminocyclopropane-1-Carboxylate) During Flower Budabscission Indicate An Important Role Of Alternate Bearing, Muhammet Ali̇ Gündeşli̇, Sali̇h Kafkas, Şenay Karabiyik, Si̇nan Eti̇, Nesi̇be Ebru Kafkas Jan 2022

Study Of Anatomical And Acc (1-Aminocyclopropane-1-Carboxylate) During Flower Budabscission Indicate An Important Role Of Alternate Bearing, Muhammet Ali̇ Gündeşli̇, Sali̇h Kafkas, Şenay Karabiyik, Si̇nan Eti̇, Nesi̇be Ebru Kafkas

Turkish Journal of Agriculture and Forestry

This study investigates whether, and how, 1-aminocyclopropane-1-carboxylic acid (ACC) is concerned in flower bud abscission of pistachio (Pistacia vera L.). Abscission was studied about the activation of the abscission zone, located between shoot and flower bud, from Uzun pistachio cultivar where the abscission profiles and the scanning electron micrographs pictorial differences in the abscission program, under natural conditions of flower bud. ACC content was investigated in the flower bud abscission zone during growth and abscission using liquid chromatography coupled with electrospray tandem mass spectrometry (UPLC/ESI-MS/MS). Results showed that abscission layers were started at first 45 days after full blooming (DAFB) …


The Effects Of Zinc Oxide Nanoparticles Loaded With Iaa And Iba On In Vitro Rooting Ofapple Microcuttings, Shabnam Alizadeh, Hati̇ce Dumanoğlu Jan 2022

The Effects Of Zinc Oxide Nanoparticles Loaded With Iaa And Iba On In Vitro Rooting Ofapple Microcuttings, Shabnam Alizadeh, Hati̇ce Dumanoğlu

Turkish Journal of Agriculture and Forestry

In the micropropagation of difficult-to-root plants, the low rates of rooting cause high economic losses. The local apple (Malus domestica Borkh.) cultivar #67, which is highly resistant to fire blight disease, has been shown to have low rooting success. Nanoparticles loaded with auxins could increase the rooting success with their physicochemical properties. To increase rooting percentage, the effects of zinc oxide nanoparticles (nZnO), nZnO loaded with indole-3-acetic acid (IAA-nZnO) and indole-3-butyric acid (IBA-nZnO) at different concentrations (1.0, 2.0, 3.0, 4.0, 5.0, and 6.0 mg L-1) on in vitro rooting of microcuttings were investigated. The concentrations of auxin carried by the …


Comparative Study Of Phenolic Compounds In Olive Oils From Differentgeographic Regions, Şeyma Şi̇şi̇k Oğraş Jan 2022

Comparative Study Of Phenolic Compounds In Olive Oils From Differentgeographic Regions, Şeyma Şi̇şi̇k Oğraş

Turkish Journal of Agriculture and Forestry

In this study, the effect of cultivar, harvest year, and the geographic regions (Mediterranean, Aegean, Southeastern Anatolia, Marmara, and the Black Sea) on phenolic compounds of virgin olive oils were investigated. Tyrosol was the major phenolic compound in the Mediterranean, Southeastern, and Black Sea regions. Hydroxytyrosol showed the highest value (2.07 mg/kg) in the Southeastern Anatolia region and the lowest value (0.75 mg/kg) in the Marmara region. Among the phenolic acids, vanillic acid had an important place in phenolic compounds (p < 0.01). This phenolic acid gave higher values in the Marmara region compared to other regions. Flavonoids were determined as important groups of phenolic compounds in olive oils. The oils from the Southeastern Anatolia region separated from other oils with the highest levels of flavonoids such as quercetin, luteolin, and apigenin. All phenolic compounds, except transcinnamic acid and quercetin, increased in the second harvest year. Vanillic acid was the highest phenolic compound in the first year, in contrast, tyrosol had higher values than vanillic acid in the second year. Many phenolic compounds were affected by olive cultivar. Memecik has a higher content of tyrosol, vanillic acid, p-coumaric acid, ferulic acid, and quercetin in the Aegean region. However, this variety showed higher values for hydroxytyrosol, transcinnamic acid, luteolin, and apigenin in the Marmara region. Gemlik, Ayvalık, Çelebi, Domat and Memecik from Marmara regions had higher vanillic acid. Butko, Otur and Kızıl Satı showed higher tyrosol. Principal component analysis showed that phenolic compounds could play an important role in the separation of regions and cultivars.


In Vitro Salinity Stress Mediates Grass Pea Genotypes' (Lathyrus Sativus L.) Responses, Zahra Khosravi, Alireza Pourmohammad, Ali Asghar Aliloo, Saleh Shahabivand, Mohammad Bagher Hassanpouraghdam, Hayat Topçu Jan 2022

In Vitro Salinity Stress Mediates Grass Pea Genotypes' (Lathyrus Sativus L.) Responses, Zahra Khosravi, Alireza Pourmohammad, Ali Asghar Aliloo, Saleh Shahabivand, Mohammad Bagher Hassanpouraghdam, Hayat Topçu

Turkish Journal of Agriculture and Forestry

This study was carried out to determine the tolerance of grass pea genotypes to salinity stress at callus and seedling stages under in vitro conditions. The calli and seedlings of six selected tolerant genotypes based on the primary screening in the field were separately exposed to salinity treatments (0, 125 mM) in vitro. Salinity was imposed with NaCl during in vitro culture, and it significantly affected all seedling traits. Genotype of Iran had the lowest seedling dry weight and therefore was more sensitive to salinity stress. According to salinity tolerance indices for seedlings, genotype Greece-III was characterized as high-yield and …


Chromium Toxicity In Plants: Consequences On Growth, Chromosomal Behavior Andmineral Nutrient Status, Muhammad Hamzah Saleem, Javaria Afzal, Muhammad Rizwan, Zia-Ul-Hassan Shah, Nizamuddin Depar, Kamal Usman Jan 2022

Chromium Toxicity In Plants: Consequences On Growth, Chromosomal Behavior Andmineral Nutrient Status, Muhammad Hamzah Saleem, Javaria Afzal, Muhammad Rizwan, Zia-Ul-Hassan Shah, Nizamuddin Depar, Kamal Usman

Turkish Journal of Agriculture and Forestry

Chromium (Cr) is a heavy metal of commercial importance; thus, significant amounts are released in wastewaters. The mobility and distribution of metals in the environment is related not only to their concentration but also to their availability in the environment. Most chromium (Cr) exists in oxidation states ranging from 0 to VI in soils but the most stable and common forms are Cr(0), Cr(III), and Cr(VI) species. Cr can have positive and negative effects on health, according to the dose, exposure time, and its oxidation state. Its behavior in soil, its soil-plant transfer and accumulation in different plant parts vary …


Effect Of Bursaphelenchus Spp. Inoculation On Carbohydrate Concentrations Of Differentpine Species In Forest Stands Of Düzce Forest Directorate, Nuray Öztürk, Süleyman Akbulut, İsmai̇l Baysal, Şemsetti̇n Kulaç Jan 2022

Effect Of Bursaphelenchus Spp. Inoculation On Carbohydrate Concentrations Of Differentpine Species In Forest Stands Of Düzce Forest Directorate, Nuray Öztürk, Süleyman Akbulut, İsmai̇l Baysal, Şemsetti̇n Kulaç

Turkish Journal of Agriculture and Forestry

The pinewood nematode (Bursaphelenchus xylophilus) is one of the most important pathogens of conifer forests worldwide that causes the pine wilt disease. This problem has increased the scientific interest in Bursaphelenchus species both in the world and in Turkey. Previously, six Bursaphelenchus species were isolated from wilted pine trees in Turkey. The main goal of this study was to investigate the effects of nematode inoculation on the total carbohydrate concentrations of tree species. Native six Bursaphelenchus species were inoculated on three pine species (Pinus pinaster, P. nigra, and P. sylvestris) under natural stand conditions. Two different doses of nematodes (2000 …


Cover And Contents Jan 2022

Cover And Contents

Turkish Journal of Agriculture and Forestry

No abstract provided.


Donor Chimerism And Immune Reconstitution Following Haploidentical Transplantation In Sickle Cell Disease, Yaya Chu, Brenda Grossman, Shalini Shenoy, Et Al Jan 2022

Donor Chimerism And Immune Reconstitution Following Haploidentical Transplantation In Sickle Cell Disease, Yaya Chu, Brenda Grossman, Shalini Shenoy, Et Al

2020-Current year OA Pubs

INTRODUCTION: We previously reported the initial results of a phase II multicenter transplant trial using haploidentical parental donors for children and aolescents with high-risk sickle cell disease achieving excellent survival with exceptionally low rates of graft-versus-host disease and resolution of sickle cell disease symptoms. To investigate human leukocyte antigen (HLA) sensitization, graft characteristics, donor chimerism, and immune reconstitution in these recipients.

METHODS: CD34 cells were enriched using the CliniMACS

RESULTS: HLA antibodies were detected in 7 of 11 (64%) evaluable patients but rarely were against donor antigens. Myeloid engraftment was rapid (100%) at a median of 9 days. At 30 …


White Matter Abnormalities In The Hdc Knockout Mouse, A Model Of Tic And Ocd Pathophysiology, Kantiya Jindachomthong, Chengran Yang, Yuegao Huang, Daniel Coman, Maximiliano Rapanelli, Fahmeed Hyder, Joseph Dougherty, Luciana Frick, Christopher Pittenger Jan 2022

White Matter Abnormalities In The Hdc Knockout Mouse, A Model Of Tic And Ocd Pathophysiology, Kantiya Jindachomthong, Chengran Yang, Yuegao Huang, Daniel Coman, Maximiliano Rapanelli, Fahmeed Hyder, Joseph Dougherty, Luciana Frick, Christopher Pittenger

2020-Current year OA Pubs

INTRODUCTION: An inactivating mutation in the

MATERIALS AND METHODS: We performed exploratory RNA-seq to identify pathological alterations in several brain regions in

RESULTS: Exploratory RNA-Seq analysis revealed, unexpectedly, that genes associated with oligodendrocytes and with myelin production are upregulated in the dorsal striatum of these mice. This was confirmed by qPCR, immunostaining, and immunoblotting. These results suggest an abnormality in myelination in the striatum. To test this in an intact mouse brain, we performed whole-brain

DISCUSSION: While the DTI literature in individuals with TS is sparse, these results are consistent with findings of disrupted descending cortical projections in patients with …


Do The Expert Recommendations For Implementing Change (Eric) Strategies Adequately Address Sustainment?, Nicole Nathan, Byron J Powell, Rachel C Shelton, Celia V Laur, Luke Wolfenden, Maji Hailemariam, Sze Lin Yoong, Rachel Sutherland, Melanie Kingsland, Thomas J Waltz, Alix Hall Jan 2022

Do The Expert Recommendations For Implementing Change (Eric) Strategies Adequately Address Sustainment?, Nicole Nathan, Byron J Powell, Rachel C Shelton, Celia V Laur, Luke Wolfenden, Maji Hailemariam, Sze Lin Yoong, Rachel Sutherland, Melanie Kingsland, Thomas J Waltz, Alix Hall

2020-Current year OA Pubs

BACKGROUND: Sustainability science is an emerging area within implementation science. There is limited evidence regarding strategies to best support the continued delivery and sustained impact of evidence-based interventions (EBIs). To build such evidence, clear definitions, and ways to operationalize strategies specific and/or relevant to sustainment are required. Taxonomies and compilations such as the Expert Recommendations for Implementing Change (ERIC) were developed to describe and organize implementation strategies. This study aimed to adapt, refine, and extend the ERIC compilation to incorporate an explicit focus on sustainment. We also sought to classify the specific phase(s) of implementation when the ERIC strategies could …


Predicting Climate-Sensitive Water-Related Disease Trends Based On Health, Seasonality And Weather Data In Fiji, Sarah Nelson, Aaron Jenkins, Stacy D. Jupiter, Pierre Horwitz, Sangeeta Mangubhai, Seye Abimbola, Anaseini Ratu, Timoci Naivalulevu, Joel Negin Jan 2022

Predicting Climate-Sensitive Water-Related Disease Trends Based On Health, Seasonality And Weather Data In Fiji, Sarah Nelson, Aaron Jenkins, Stacy D. Jupiter, Pierre Horwitz, Sangeeta Mangubhai, Seye Abimbola, Anaseini Ratu, Timoci Naivalulevu, Joel Negin

Research outputs 2022 to 2026

Leptospirosis, typhoid and dengue are three water-related diseases influenced by environmental factors. We examined whether seasonality and rainfall predict reported syndromes associated with leptospirosis, typhoid and dengue in Fiji. Poisson generalised linear models were fitted with s6 early warning, alert and response system (EWARS) syndromic conditions from March 2016 until December 2020, incorporating seasonality, temperature and rainfall. Watery diarrhoea, prolonged fever and suspected dengue displayed seasonal trends with peaks corresponding with the rainy season, while bloody diarrhoea, acute fever with rash and acute jaundice syndrome did not. Seasonality was the most common predictor for watery and bloody diarrhoea, prolonged fever, …


Artificial Intelligence-Based Material Discovery For Clean Energy Future, Reza Maleki, Mohsen Asadnia, Amir Razmjou Jan 2022

Artificial Intelligence-Based Material Discovery For Clean Energy Future, Reza Maleki, Mohsen Asadnia, Amir Razmjou

Research outputs 2022 to 2026

Artificial intelligence (AI)-assisted materials design and discovery methods can come to the aid of global concerns for introducing new efficient materials in different applications. Also, a sustainable clean future requires a transition to a low-carbon economy that is material-intensive. AI-assisted methods advent as inexpensive and accelerated methods in the design of new materials for clean energies. Herein, the emerging research area of AI-assisted material discovery with a focus on developing clean energies is discussed. The applications, advantages, and challenges of using AI in material discovery are discussed and the future perspective of using AI in clean energy is studied. This …


Evaluation Of Virtual Screening Strategies For The Identification Of Γ-Secretase Inhibitors And Modulators, Alicia Ioppolo, Melissa Eccles, David Groth, Giuseppe Verdile, Mark Agostino Jan 2022

Evaluation Of Virtual Screening Strategies For The Identification Of Γ-Secretase Inhibitors And Modulators, Alicia Ioppolo, Melissa Eccles, David Groth, Giuseppe Verdile, Mark Agostino

Research outputs 2022 to 2026

γ-Secretase is an intramembrane aspartyl protease that is important in regulating normal cell physiology via cleavage of over 100 transmembrane proteins, including Amyloid Precursor Protein (APP) and Notch family receptors. However, aberrant proteolysis of substrates has implications in the progression of disease pathologies, including Alzheimer’s disease (AD), cancers, and skin disorders. While several γ-secretase inhibitors have been identified, there has been toxicity observed in clinical trials associated with non-selective enzyme inhibition. To address this, γ-secretase modulators have been identified and pursued as more selective agents. Recent structural evidence has provided an insight into how γ-secretase inhibitors and modulators are recognized …


Connectivity Shapes Functional Diversity And Maintains Complementarity In Surf Zones On Exposed Coasts, Christopher J. Henderson, Ben L. Gilby, Andrew D. Olds, Jesse Mosman, Rod M. Connolly, Glenn Hyndes, Brendan Kelaher, Brooke Maslo, Alan Williams, Thomas A. Schlacher Jan 2022

Connectivity Shapes Functional Diversity And Maintains Complementarity In Surf Zones On Exposed Coasts, Christopher J. Henderson, Ben L. Gilby, Andrew D. Olds, Jesse Mosman, Rod M. Connolly, Glenn Hyndes, Brendan Kelaher, Brooke Maslo, Alan Williams, Thomas A. Schlacher

Research outputs 2022 to 2026

Habitat complexity and connectivity can influence the number of species and their diversity across a landscape. For the surf zones of ocean-exposed beaches, globally one of the longest habitat interfaces, the assumed low structural complexity, and apparent homogeneity, of the sandy seafloor habitats predicts low taxonomic and functional diversity. Here, we assessed how the configuration of the seascape and the context of different beach structure functional diversity and functional niche space of fish assemblages in surf zones. We expected that beaches that were well connected with highly productive and complex estuarine and reef habitats would support a greater level of …


Application Of Neuromorphic Olfactory Approach For High-Accuracy Classification Of Malts, Anup Vanarse, Adam Osseiran, Alexander Rassau, Peter Van Der Made Jan 2022

Application Of Neuromorphic Olfactory Approach For High-Accuracy Classification Of Malts, Anup Vanarse, Adam Osseiran, Alexander Rassau, Peter Van Der Made

Research outputs 2022 to 2026

Current developments in artificial olfactory systems, also known as electronic nose (e-nose) systems, have benefited from advanced machine learning techniques that have significantly improved the conditioning and processing of multivariate feature-rich sensor data. These advancements are complemented by the application of bioinspired algorithms and architectures based on findings from neurophysiological studies focusing on the biological olfactory pathway. The application of spiking neural networks (SNNs), and concepts from neuromorphic engineering in general, are one of the key factors that has led to the design and development of efficient bioinspired e-nose systems. However, only a limited number of studies have focused on …


Geostatistical Tools To Assess Shifts In Recreational Fishing, Shannon J. Burchert, Glenn A. Hyndes, Karina Ryan, Ute Mueller Jan 2022

Geostatistical Tools To Assess Shifts In Recreational Fishing, Shannon J. Burchert, Glenn A. Hyndes, Karina Ryan, Ute Mueller

Research outputs 2022 to 2026

The use of geostatistical indices to examine fishery-dependent data over time is novel. We assess the value of a range of these indices for describing trends in boat-based recreational fishing in Western Australia and areas of high effort and catches for two demersal species with varying biological characteristics, life histories and distributions. The number of blocks (10- × 10-nautical mile (~19- × 19-km) area) visited decreased by 40%, while the number of fishing trips with demersal species catch increased by 15%. Spatial indices showed a south-easterly shift in demersal catch per unit effort (CPUE) across survey years. The southerly shift …


Realistic Motion Avatars Are The Future For Social Interaction In Virtual Reality, Shane L. Rogers, Rebecca Broadbent, Jemma Brown, Allan Fraser, Craig P. Speelman Jan 2022

Realistic Motion Avatars Are The Future For Social Interaction In Virtual Reality, Shane L. Rogers, Rebecca Broadbent, Jemma Brown, Allan Fraser, Craig P. Speelman

Research outputs 2022 to 2026

This study evaluated participant self-reported appraisal of social interactions with another person in virtual reality (VR) where their conversational partner was represented by a realistic motion avatar. We use the term realistic motion avatar because: 1. The avatar was modelled to look like the conversational partner it represented, and 2. Full face and body motion capture was utilised so that the avatar mimicked the facial and body language of the conversational partner in real-time. We compared social interaction in VR with face-to-face interaction across two communicative contexts: 1. Getting acquainted conversation, and 2. A structured interview where the participant engaged …


Matrilateral Bias Of Grandparental Investment In Grandchildren Persists Despite The Grandchildren’S Adverse Early Life Experiences, Samuli Helle, Antti O. Tanskanen, David A. Coall, Mirkka Danielsbacka Jan 2022

Matrilateral Bias Of Grandparental Investment In Grandchildren Persists Despite The Grandchildren’S Adverse Early Life Experiences, Samuli Helle, Antti O. Tanskanen, David A. Coall, Mirkka Danielsbacka

Research outputs 2022 to 2026

Evolutionary theory predicts a downward flow of investment from older to younger generations, representing individual efforts to maximize inclusive fitness. Maternal grandparents and maternal grandmothers (MGMs) in particular consistently show the highest levels of investment (e.g. time, care and resources) in their grandchildren. Grandparental investment overall may depend on social and environmental conditions that affect the development of children and modify the benefits and costs of investment. Currently, the responses of grandparents to adverse early life experiences (AELEs) in their grandchildren are assessed from a perspective of increased investment to meet increased need. Here, we formulate an alternative prediction that …


Exercise In Advanced Prostate Cancer Elevates Myokine Levels And Suppresses In-Vitro Cell Growth, Jin Soo Kim, Dennis R. Taaffe, Daniel A. Galvão, Nicolas H. Hart, Elin Gray, Charles J. Ryan, Stacey A. Kenfield, Fred Saad, Robert U. Newton Jan 2022

Exercise In Advanced Prostate Cancer Elevates Myokine Levels And Suppresses In-Vitro Cell Growth, Jin Soo Kim, Dennis R. Taaffe, Daniel A. Galvão, Nicolas H. Hart, Elin Gray, Charles J. Ryan, Stacey A. Kenfield, Fred Saad, Robert U. Newton

Research outputs 2022 to 2026

Background:

Altering the systemic milieu through exercise has been proposed as a potential mechanism underlying exercise-driven tumour suppression. It is not yet known whether men with advanced prostate cancer can elicit such adaptations following a program of exercise. The purpose is to examine myokine levels of serum acquired from metastatic castrate-resistant prostate cancer (mCRPC) patients recruited to the INTERVAL-GAP4 trial before and after 6 months of exercise and its tumour-suppressive effect.

Methods:

Twenty-five men with mCRPC (age = 74.7 ± 7.1 yrs) were randomised to supervised multimodal (aerobic and resistance) exercise (EX) or self-directed exercise control group (CON). Body composition …


Sulfur Compounds: From Plants To Humans And Their Role In Chronic Disease Prevention, Caroline R. Hill, Armaghan Shafaei, Lois Balmer, Joshua R. Lewis, Jonathan M. Hodgson, A. Harvey Millar, Lauren C. Blekkenhorst Jan 2022

Sulfur Compounds: From Plants To Humans And Their Role In Chronic Disease Prevention, Caroline R. Hill, Armaghan Shafaei, Lois Balmer, Joshua R. Lewis, Jonathan M. Hodgson, A. Harvey Millar, Lauren C. Blekkenhorst

Research outputs 2022 to 2026

Sulfur is essential for the health of plants and is an indispensable dietary component for human health and disease prevention. Its incorporation into our food supply is heavily reliant upon the uptake of sulfur into plant tissue and our subsequent intake. Dietary requirements for sulfur are largely calculated based upon requirements for the sulfur-containing amino acids (SAA), cysteine and methionine, to meet the demands for synthesis of proteins, enzymes, co-enzymes, vitamins, and hormones. SAA are found in abundance in animal sources and are relatively low in plants. However, some plants, particularly cruciferous and allium vegetables, produce many protective sulfur-containing secondary …