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Impact Of Percutaneous Transluminal Intervention On Vascular Hypoxia And The Role Of Micro-Calcifications On Atherosclerotic Plaque Rupture, Andrea Corti

Dissertations and Theses

Atherosclerotic disease is initiated by cholesterol build-up beneath the endothelium, which evolves into a fibroatheroma, a lipid-rich plaque covered by a fibrous cap. Many of these plaques are considered as vulnerable, as they grow to occlude the luminal section of the artery (chronically stenotic) or become mechanically unstable with a higher chance of rupturing (rupture-prone). On one hand, chronically stenotic vulnerable plaques are symptomatic lesions that are often treated with Percutaneous Transluminal Intervention (PTI). Unfortunately, approximately 10% of PTI procedures are followed by severe Neointima Hyperplasia (NH), which causes a new occlusion and failure of the implant. A significant precursor …

Design And Control Of Quasi-Direct Drive Actuation For Lightweight And Versatile Wearable Robots, Shuangyue Yu

Dissertations and Theses

Wearable robots have shown great potential for augmenting the physical capabilities of humans in lab settings. However, wearable robots for augmenting the physical capabilities of humans under community-based conditions are the new frontier of robotics. Furthermore, the design and control are still considered to be grand challenges for providing physical augmentation for humans. In terms of design, the state-of-the-art exoskeletons are typically rigid, bulky, and limited to lab settings. In terms of control, most of the rhythmic controllers are not versatile and are focused only on steady-state walking assistance.

The motivation behind my research is to improve both the design …

The Use Of Multiple Saliency Techniques As An Explanation Interface In General Image Recognition, Robert N. Moss Mr

Dissertations and Theses

AI diagnostic machines that preform beyond that of human intelligence have yet to be implemented into society at large in substantiative ways. Examples in research of AI that can diagnose cancer, narcolepsy, renal diseases, and cardiac damage abound, yet these machines have to be implemented into clinical settings. Although predictively powerful, these diagnostic machines are powered by Deep Convolutional Neural Networks that operate as virtual black- boxes and the medical community is unwilling to accept predictions that lack explanation. To this end Explainable Artificial Intelligence is developing a host of methods that seek to pry open the inner workings DNNs …

Fundamentals Of Microgel Flooding And Nanoparticles-Stabilized Foams In Enhanced Oil Recovery, Shuaijun Li

Dissertations and Theses

For centuries oil has remained a critical energy source for human civilization. After years of extraction, many oil fields have reached or are reaching a decline stage of production, even though up to a half of the total crude oil reserves in these fields has not been recovered yet. One reason is due to the structural heterogeneity of the oil reservoirs—reservoirs may consist of regions of higher permeability with larger pore size and regions of lower permeability with smaller pore size. Displacing fluids tend to flow through large permeability zones only without reaching the oil trapped in low permeability region; …

The Impact Of Covid-19 On Building Energy Consumption In New York City, Martha A. Olaleye

Dissertations and Theses

Since February 2020, the spread of COVID-19 affected the world economy, with the population of people contacting the virus in New York City at that time being at the highest in the United States of America. Thus, the need for remote/online learning was adopted for the safety of faculty, staffs, and students of New York Educational institution like CCNY. In the study, I focused on energy consumption as regards to COVID and POST-COVID periods in New York City (NYC), since most employees are working from home and schools are online which implies that most commercial buildings are vacant. Also due …

Osseointegration Of A Cementless Total Knee Arthroplasty In A Murine Model Of Glucocorticoid Induced Osteoporosis, Elexis C. Baral

Dissertations and Theses

Glucocorticoid-Induced Osteoporosis (GIOP) is the second largest cause of osteoporosis worldwide. Glucocorticoid-Induced osteoporosis is rapidly, driven principally by deficient osteoblast activity (i.e., decreased bone formation) rather than increased osteoclastic activity. Glucocorticoid-type steroids (GC) are used long-term typically for inflammatory diseases such as rheumatoid arthritis, lupus, multiple sclerosis, and other autoimmune disorders. Inflammatory arthritis often leads to joint replacement at relatively young ages. However, patients who are on GC treatment appear to have poorer outcomes for total joint arthroplasty compared to healthy patients. This is thought to be due to the anti-anabolic effects of GCs and impaired bone healing and osseous …

Nonlinear Light - Matter Interactions Of Ultrafast High Intensity Laser Pulses, Henry Meyer

Dissertations and Theses

This thesis focuses on the key nonlinear optical effects that arise from the interactions of intense ultrafast laser pulses with various states of matter. These interactions involve electronic and molecular states and yield new information on the underlying fundamental processes that govern the molecular world. Modern day lasers offer ultrashort pulses, high intensities, and complex polarizations and wavefronts. These extreme conditions have profound effect on the optical properties and behaviors of electronic and molecular states within a material. The changes in these mechanisms effect generation of nonlinear optics, such supercontinuum (SC), stimulated Raman (SRS), self-focusing and filamentation, conical emission (CE), …

Computational Model Of Electroconvulsive Therapy Considering Electric Field Dependent Skin Conductivity, Gozde Unal

Dissertations and Theses

Improvements in electroconvulsive therapy (ECT) outcomes have followed refinement in device electrical output and electrode montage. The physical properties of the ECT stimulus, together with those of the patient’s head, determine the impedances measured by the device and govern current delivery to the brain and ECT outcomes. However, the precise relations among physical properties of the stimulus, patient head anatomy, and patient-specific impedance to the passage of current are long-standing questions in ECT research and practice. In this thesis, we develop a computational framework based on diverse clinical data sets. We developed anatomical MRI-derived models of transcranial electrical stimulation (tES) …

Droplets In An Electric Field: Surface Rheology, Coalescence And Rebound, Yu Han

Dissertations and Theses

Electrocoalescence is the process in which pairs of conducting droplets suspended in a continuous dielectric (nonconducting) liquid phase are drawn together and merge upon the application of an electric field. The electric field polarizes each of the droplets in the field direction. The polarization causes the drops to deform and drives a dipolar attraction which forces them to approach each other and coalesce. Many technologies use electric fields to manipulate fluid dispersions. Electrocoalescence is an essential unit operation for separating water droplets in a crude oil. This water in oil emulsion is stabilized by surfactants, such as asphaltenes, resins and …

Development Of Cellulose-Based, Semi-Interpenetrating Network Hydrogels As Tissue-Adhesive, Thermoresponsive, Injectable Implants, Jesse Martin

Dissertations and Theses

Abstract Development of Cellulose-Based, Semi-Interpenetrating Network Hydrogels as Tissue-Adhesive, Thermoresponsive, Injectable Implants

Hydrogels are three-dimensional polymer networks with high water content and tunable mechanical properties, which have been widely investigated as replacements for soft tissues, such as the intervertebral disc (IVD). Various derivatives of the plant polysaccharide, cellulose, have been explored for use as injectable hydrogel implants. Methylcellulose (MC), which exhibits thermogelation at temperatures above 32°C, and relatively hydrophilic carboxymethyl-cellulose (CMC), are versatile cellulosic polymers that have shown promise as base materials for such applications. In prior work, functionalization with methacrylate groups allowed for the formation of stable, covalently crosslinked …

Low-Intensity Ultrasonic Neuromodulation Of The Rat Hippocampus, Duc Nguyen

Dissertations and Theses

Techniques to non-invasively modulate brain activity are important for mapping human brain circuits, and also for the treatment of a host of neurological and psychiatric disorders marked by aberrant brain activity. Though a wide range of techniques for non-invasive neuromodulation have been proposed, the conventional approaches suffer from significant limitations. Most notably, focal stimulation of deep brain regions is presently only possible with invasive optogenetic and chemogenetic approaches that require craniotomies and genetic access to the brain.

Transcranial focused ultrasound stimulation (tFUS) possesses many of the characteristics desirable from a neuromodulation approach: non-invasiveness, a spatial resolution in the order of …

Investigation Of Reactions Occurring In Municipal Solid Waste Residues, Tasnuva T. Moutushi

Dissertations and Theses

Each year more than 290 million tons of municipal solid waste (MSW) is generated in the U.S. Understanding the reactions occurring in waste during disposal, transport, and storage is important to move towards an integrated waste management strategy. Recently some landfills in the U.S. have been reported to exceed the regulatory temperature range, causing numerous regulatory challenges. The reason for this phenomenon is still unidentified. In addition, the co-disposal of the MSW ash in landfills lead to various reactions which can impact the landfill environment. Understanding the reactions occurring in the MSW and in ash is essential to minimize and …

Population Structure Of The Lizard Ecpleopus Gaudichaudii Coincides With A Biogeographic Barrier - The Doce River, Alexander J. Garretson

Dissertations and Theses

Intraspecific genetic variation is an integral component of diversification and the accumulation of biodiversity. The degree to which isolated populations of the same species are genetically structured in geographical space is impacted by a variety of mechanisms. In this study, I document patterns and discuss possible drivers of genetic structure within Ecpleopus gaudichaudii, a lizard species endemic to the Atlantic Forest of Brazil. For that, I assembled ddRadseq sequences from 48 individuals across much of the range of the E. gaudichaudii and analyzed its population structure. I created an intraspecific phylogeny for this group utilizing RAxML and conducted a …

Discrimination Against Veiled Women In The West: Social Isolation, Amina M. Abdallah

Dissertations and Theses

This research examines the discriminatory practices faced by veiled women in the West that impede their integration into their local communities or lead them to feel socially isolated. Societal prejudice and, in some cases, the laws of the land often solidify this isolation of Muslim women and girls from the rest of the world. These victims of social oppression face discrimination based on multiple factors, such as their religion, race, and sex.

This study analyses preconceived notions regarding veiled women, incorporating evidence from seventeen qualitative interviews done with veiled Muslim women residing in the West, particularly the United States, United …

Holistic Treatment: A Qualitative Study Of The Integration Of Chinese Medicine With Psychoanalysis In China, I. Wang

Dissertations and Theses

With its fundamental principle of body-mind unity, Chinese medicine has long been regarded as one of the most influential bedrocks of holistic treatment. Given its prevalence in China, Chinese medicine (CM) is a culturally appropriate way for therapists in China to integrate with psychoanalysis. This qualitative study investigates how Chinese psychotherapists in China with Western psychanalytic backgrounds synthesize the principles and methods of CM into their practice. Further, the barriers and facilitators to the integration are also examined. With a sample of twelve Chinese psychotherapists in China primarily trained at The China American Psychoanalytic Alliance, through semi-structured interviews, therapists' integration …

Trapped Under Ice: Spatial And Seasonal Dynamics Of Dissolved Organic Matter Composition In Tundra Lakes, Martin R. Kurek, Karen E. Frey, François Guillemette, David C. Podgorski, Amy Townsend-Small, Christopher D. Arp, Anne M. Kellerman, Robert G.M. Spencer

Geography

Arctic lakes store, modify, and transport large quantities of carbon from terrestrial environments to the atmosphere; however, the spatial and temporal relationships between quantity and composition of dissolved organic matter (DOM) have not been well characterized across broad arctic regions. Moreover, most arctic lake DOM compositions have been examined during the ice-free summer, whereas DOM cycling between the ice-covered winter months and summer have not been addressed. To resolve these spatial and seasonal uncertainties in DOM cycling, we sampled a series of arctic lakes from the North Slope of Alaska across a latitudinal gradient in the winter and summer over …

Epidemiology And Characteristics Of Chronic Pancreatitis—Do The East And West Meet?, Nikita Desai, Tarun Kaura, Maharaj Singh, Field F. Willingham, Surinder Rana, Saurabh Chawla

College of Nursing Faculty Research and Publications

Background and Aims

Previous large studies on the epidemiology and clinical profile of chronic pancreatitis have suggested significant differences in presentation and management in the eastern and western hemispheres. The aim of this systematic review was to compare large multicenter studies across different geographic regions of the world to detect meaningful differences in the presentation and management of this poorly understood disease.

Methods

We identified 237 manuscripts through a comprehensive literature review aiming to identify multicenter studies enrolling more than 200 patients to limit reporting biases. After rigorous screening, 12 studies were included for the final analysis. The Asian studies …

Outsourcing Enforcement, Desiree Leclercq

Scholarly Works

International organizations often outsource the enforcement of international law to their member states. The International Labor Organization (ILO), for instance, has neither its own adjudicative body nor an internal system of sanctions. Instead, the ILO’s maritime rules authorize states to impose costly retributive measures against noncompliant states. Conventional scholars are optimistic that these kinds of authorizations will strengthen otherwise toothless international law. During the COVID-19 pandemic, however, states neither followed nor enforced the ILO’s rules, harming hundreds of thousands of seafarers in the process.

Where has international law gone wrong? Challenging the conventional view, this Article unearths the state-centric drawbacks …

Updates On Hydroxychloroquine In Prevention And Treatment Of Covid-19, Heather Johnson

All Publications

No abstract provided.

Arctic Stream Characteristics And Diet Analysis Choice Impact Condition And Diet Estimates Of Ninespine Stickleback (Pungitius Pungitius), Adam Kuhrt

Theses and Dissertations (Comprehensive)

Ninespine stickleback (Pungitius pungitius) are ubiquitous in circumpolar freshwaters, but their ecological role is not well understood. Little research has been conducted on the influence of environmental variables on ninespine stickleback in stream environments, and while they are understood to be generalist feeders, their diet in stream environments is equally understudied. Determining diet is difficult due to biases inherent in all standard diet analysis methods. Morphological gut-content analysis (M-GCA), DNA metabarcoding of gut contents (D-GCA), and stable isotope analysis (SIA) are currently three of the most frequently conducted diet analyses; and while combinations of these methods are commonly …

Biyyaa Baanus Biyyi Nu Keessaa Hinbaatu: Changing Gender Norms And Traditional Mediation Impacts On Marriage Among Ethiopian Immigrants In Three Southwestern Ontario Cities, Dinku Korsa

Theses and Dissertations (Comprehensive)

Abstract Immigrant spouses face culture shock in the host countries because they are disconnected from their social fabric and, at the same time, must adhere to the host countries' lifestyles. One of the immigrants' spouses' challenges is the marital conflicts that arise because of changing gender norms in the host countries and the absence of family support to solve their conflicts. The purpose of this study is to examine changing gender norms and traditional meditation's impact on marriage among Ethiopian immigrants living in Kitchener, Waterloo and Guelph. The study asks overarching research question: what is the impact of changing gender …

Community Stress And Resilience During Covid-19: Assessing The Emotional Profile Of The City Of Hamilton Using A Social Media Analysis, Senyo Agbeyaka

Theses and Dissertations (Comprehensive)

This study investigated stress and resilience at the neighbourhood level in Hamilton Ontario in pre- and peri-pandemic conditions using a social media analysis. Sentiment analysis of geo-located Twitter posts produced within Hamilton census tract boundaries was conducted using Stresscapes and EMOTIVE, validated software that extract and code emotional information from human language expressions about stress and hope (a proxy for stress), respectively. Baseline levels of both emotions were measured using aggregate scores at the census tract level in Hamilton from tweets produced during two pre-pandemic periods (March 2019 to July 2019; and August 2019 to February 2020), with a replication …

Insights Into The Virulence Of Campylobacter Jejuni Associated With Two-Component Signal Transduction Systems And Single Regulators, Gahamanyi Noel, Dae-Geun Song, Leonard E. G. Mboera, Mecky I. Matee, Dieudonné Mutangana, Raghavendra G. Amachawadi, Erick V. G Komba, Cheol-Ho Pan

All Rsif Scholars' Publications

Abstract

An Agent-Centered Approach To Covid-19 Vaccinations, Nila Venkat

CMC Senior Theses

The rise of COVID-19 has dramatically affected the global economy, healthcare systems, and individuals’ daily lives. One of the most controversial attempts to ameliorate the effects of the virus in the United States has been the distribution of COVID-19 vaccinations. In this thesis, I propose a novel agent-centered approach to motivating COVID-19 vaccinations. I begin by exploring the origins and evolution of the virus, along with the growing demographic of “vaccine-hesitant” Americans, to contextualize the debate surrounding vaccinations. I then propose two potential action-based response strategies for vaccine motivation: a vaccine mandate and nudges. Concerning a mandate response strategy, I …

Impact Of College Extracurricular Involvement On Entrepreneurial Outcomes, Emily Malech

CMC Senior Theses

Despite extensive inquiry, relatively little is understood about the factors which shape entrepreneurs as young adults. This paper examines the impact of college extracurricular involvement on the entrepreneurial outcomes of alumni; it considers which extracurricular activities are most strongly associated with entrepreneurship. Additionally, it explores whether the number of extracurricular activities participated in by students impacts their proclivity for entrepreneurship. It observes 219 alumni of Claremont McKenna College and uses data from the institution’s public records as well as alumni’s LinkedIn profiles. This data contains information on entrepreneurship, indicated by job titles, and five extracurricular activities. Using a probit model …

Over-Wintering Grounds Social Behavior Of White-Crowned Sparrows, Lauryn Jeans

CMC Senior Theses

White-Crowned Sparrows (WCSP), Zonotrichia leucophrys gambelii, are small, migrating passerine birds whose over-wintering ground social behavior is poorly researched. Suitable wintering grounds must balance climate preference and migration length, are affected by territory size and habitat competition, and have long-term effects on bird fitness. A study observed Golden-Crowned Sparrows (Zonotrichia atricapilla) returning every year to the same wintering ground and forming strong social communities during those winter months. We predicted that WCSPs exhibit wintering ground fixation and form stable flock structure at the Bernard Field Station (BFS) in Southern California during the winter months of October to …

Putative Mechanisms Underlying The Antidepressant Actions Of Ketamine: A Review And Study Proposal, Tristan Reece

CMC Senior Theses

Major Depressive Disorder (MDD) is a highly debilitating and common psychiatric disorder that affects over 250 million people globally; it is among the most financially and emotionally burdensome illnesses in the world. Currently approved antidepressants are suboptimal in their efficacy and latency of therapeutic action. In contrast, single administrations of sub-anesthetic ketamine have been shown to rapidly alleviate depressive symptoms within hours, even in treatment-resistant patients. Ketamine is believed to exert these effects by increasing glutamatemediated neurotransmission and promoting rapid neurotrophic factor release, restoring the integrity of neural circuits that are compromised in depression. However, uncertainty surrounding its specific antidepressant …

Analyzing Marriage Statistics As Recorded In The Journal Of The American Statistical Association From 1889 To 2012, Annalee Soohoo

CMC Senior Theses

The United States has been tracking American marriage statistics since its founding. According to the United States Census Bureau, “marital status and marital history data help federal agencies understand marriage trends, forecast future needs of programs that have spousal benefits, and measure the effects of policies and programs that focus on the well-being of families, including tax policies and financial assistance programs.”[1] With such a wide scope of applications, it is understandable why marriage statistics are so highly studied and well-documented.

This thesis will analyze American marriage patterns over the past 100 years as documented in the Journal of …

Energy As A Limiting Factor In Neuronal Seizure Control: A Mathematical Model, Sophia E. Epstein

CMC Senior Theses

The majority of seizures are self-limiting. Within a few minutes, the observed neuronal synchrony and deviant dynamics of a tonic-clonic or generalized seizure often terminate. However, a small epilesia partialis continua can occur for years. The mechanisms that regulate subcortical activity of neuronal firing and seizure control are poorly understood. Published studies, however, through PET scans, ketogenic treatments, and in vivo mouse experiments, observe hypermetabolism followed by metabolic suppression. These observations indicate that energy can play a key role in mediating seizure dynamics. In this research, I seek to explore this hypothesis and propose a mathematical framework to model how …

Mary Eleanor Spear's Importance To The History Of Statistical Visualization, Melanie Williams

CMC Senior Theses

This paper will demonstrate why Mary Eleanor Spear (1897-1986) is an important figure in the history of statistical visualization. She lead an impressive career working in the federal government as a data analyst before "data analyst" became a thing. She wrote and illustrated two comprehensive textbooks which furthered the art of statistical visualization. Her textbooks cover extensive graphing knowledge still valuable to statisticians and viewers today. Most notable of her works is her development of the box plot. In addition to Spear's career and contributions, this paper will also address the lack of female representation in science, technology, engineering, and …