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Looking Past Blindness: Assessing Mental Health In Stargardt Disease, Sebastian A. Schormann, Clinton Martin

UAB Huntsville Research Day - All Presentations

2022 clinical vignette poster

The Effects Of Received Grandmothers’ Affection On Adult Grandchildren’S Health Behaviors Using Affection Exchange Theory, Leslie Ramos Salzar, Priyanka Khandelwal, Yvette Castillo

Department of Marketing: Faculty Publications

Background: Affection exchange theory (AET) explains the value of received affection for overall wellbeing in family relationships. However, this study extends prior work by investigating AET in grandmother-grandchild relationships and grandchildren’s individual well-being. This study seeks to understand the relationships between adult grandchildren’s received grandmother affection and health-related behaviors such as diet, exercise, substance abuse, and sleep.

Methods: This cross-sectional study included 229 university student participants. Multiple regression analyses were performed to analyze received grandmother affection and grandchildren’s health behaviors.

Results: Using cross-sectional survey methods, it was found that grandchildren’s reports of received memories and humor, and celebratory affection influenced …

Circling The Drain: The Extinction Crisis And The Future Of Humanity, Rodolfo Dirzo, Gerardo Ceballos, Paul R. Ehrlich

Harold W. Manter Laboratory of Parasitology: Library Materials

Humanity has triggered the sixth mass extinction episode since the beginning of the Phanerozoic. The complexity of this extinction crisis is centered on the intersection of two complex adaptive systems: human culture and ecosystem functioning, although the significance of this intersection is not properly appreciated. Human beings are part of biodiversity and elements in a global ecosystem. Civilization, and perhaps even the fate of our species, is utterly dependent on that ecosystem’s proper functioning, which society is increasingly degrading. The crisis seems rooted in three factors. First, relatively few people globally are aware of its existence. Second, most people who …

Promising Findings That The Cultivating Healthy Intentional Mindful Educators’ Program (Chime) Strengthens Early Childhood Teachers’ Emotional Resources: An Iterative Study, Holly Hatton-Bowers, Caron Clark, Gilbert R. Parra, Jessica L. Calvi, Michael Yellow Bird, Pearl Avari, Jaclynn Foged, John Smith

Department of Child, Youth, and Family Studies: Faculty Publications

Findings suggest that an eight-week mindfulness compassion-based program, Cultivating Healthy Intentional Mindful Educators (CHIME), is a feasible professional development intervention for early childhood (EC) teachers to support their emotion regulation and psychological and workplace well-being. We offer preliminary evidence that learning about mindfulness, self-compassion, and social-emotional learning supports EC teachers in strengthening their knowledge and application of practices to be more mindful and less emotionally reactive and emotionally exhausted at work. In analyzing both EC teacher feedback and survey data from two pilot studies, there was promising evidence that participating in CHIME enhanced awareness of emotions and the development of …

Investigating Moderators Of Daily Marital To Parent–Child Spillover: Individual And Family Systems Approaches, Patty X. Kuo, Kejin Lee, Victoria J. Johnson, Emily J. Starr

Department of Child, Youth, and Family Studies: Faculty Publications

Objective: We tested whether cognitive reappraisal and coparenting quality moderate marital to parent–child spillover in mothers and fathers.

Background: The influence of marital relationship quality on parent–child relationships, referred to as the spillover effect, is well documented. Factors that may attenuate the occurrence of spillover, however, remain unclear. Cognitive reappraisal, an emotion regulation strategy that promotes the reframing of emotional situations as neutral or positive, and coparenting—the intermediate subsystem between the marital and parent–child relationships—may buffer the effects of marital to parent–child spillover.

Method: Using daily diary data from mother–father couples (N = 96) of young children (M_age = …

High Throughput Analysis Of Leaf Chlorophyll Content In Sorghum Using Rgb, Hyperspectral, And Fluorescence Imaging And Sensor Fusion, Huichun Zhang, Yufeng Ge, Xinyan Xie, Abbas Atefi, Nuwan Wijewardane,, Suresh Thapa

School of Computing: Faculty Publications

Leaf chlorophyll content plays an important role in indicating plant stresses and nutrient status. Traditional approaches for the quantification of chlorophyll content mainly include acetone ethanol extraction, spectrophotometry and high-performance liquid chromatography. Such destructive methods based on laboratory procedures are time consuming, expensive, and not suitable for high-throughput analysis. High throughput imaging techniques are now widely used for non-destructive analysis of plant phenotypic traits. In this study three imaging modules (RGB, hyperspectral, and fluorescence imaging) were, separately and in combination, used to estimate chlorophyll content of sorghum plants in a greenhouse environment. Color features, spectral indices, and chlorophyll fluorescence intensity …

Data Science Applied To Discover Ancient Minoan-Indus Valley Trade Routes Implied By Commonweight Measures, Peter Revesz

School of Computing: Conference and Workshop Papers

This paper applies data mining of weight measures to discover possible long-distance trade routes among Bronze Age civilizations from the Mediterranean area to India. As a result, a new northern route via the Black Sea is discovered between the Minoan and the Indus Valley civilizations. This discovery enhances the growing set of evidence for a strong and vibrant connection among Bronze Age civilizations.

Mr-Pipa: An Integrated Multi-Level Rram (Hfox) Based Processing-In-Pixel Accelerator, Minhaz Abedin, Arman Roohi, Maximilian Liehr, Nathaniel Cady, Shaahin Angizi

School of Computing: Faculty Publications

This work paves the way to realize a processing-in-pixel accelerator based on a multi-level HfO_x RRAM as a flexible, energy-efficient, and high-performance solution for real-time and smart image processing at edge devices. The proposed design intrinsically implements and supports a coarse-grained convolution operation in low-bit-width neural networks leveraging a novel compute-pixel with non-volatile weight storage at the sensor side. Our evaluations show that such a design can remarkably reduce the power consumption of data conversion and transmission to an off-chip processor maintaining accuracy compared with the recent in-sensor computing designs. Our proposed design, namely MR-PIPA, achieves a frame rate …

Male Mastodon Landscape Use Changed With Maturation (Late Pleistocene, North America), Joshua H. Miller, Daniel C. Fisher, Brooke E. Crowley, Ross Secord, Bledar A. Konomi

Department of Earth and Atmospheric Sciences: Faculty Publications

Under harsh Pleistocene climates, migration and other forms of seasonally patterned landscape use were likely critical for reproductive success of mastodons (Mammut americanum) and other megafauna. However, little is known about how their geographic ranges and mobility fluctuated seasonally or changed with sexual maturity. We used a spatially explicit movement model that coupled strontium and oxygen isotopes from two serially sampled intervals (5+ adolescent years and 3+ adult years) in a male mastodon tusk to test for changes in landscape use associated with maturation and reproductive phenology. The mastodon’s early adolescent home range was geographically restricted, with no evidence of …

Infrared Dielectric Functions And Brillouin Zone Center Phonons Of Α-Ga2O3 Compared To Α-Al2O3, Megan Stokey, Rafal Korlacki, Matthew J. Hilfiker, Sean Knight, Steffen Richter, Vanya Darakchieva, Riena Jinno, Yongjin Cho, Huili Grace Xing, Debdeep Jena, Yuichi Oshima, Kamruzzaman Khan, Elaheh Ahmadi, Mathias Schubert

Department of Electrical and Computer Engineering: Faculty Publications

We determine the anisotropic dielectric functions of rhombohedral α-Ga₂O₃ by far-infrared and infrared generalized spectroscopic ellipsometry and derive all transverse optical and longitudinal optical phonon mode frequencies and broadening parameters. We also determine the high-frequency and static dielectric constants. We perform density functional theory computations and determine the phonon dispersion for all branches in the Brillouin zone, and we derive all phonon mode parameters at the Brillouin zone center including Raman-active, infrared-active, and silent modes. Excellent agreement is obtained between our experimental and computation results as well as among all previously reported partial information from experiment …

Serum Protein Signatures Using Aptamer-Based Proteomics For Minimal Change Disease And Membranous Nephropathy, Daniel A. Muruve, Hanna Debiec, Simon T. Dillon, Xuesong Gu, Emmanuelle Plaisier, Handan Can, Hasan H. Otu, Towia A. Libermann, Pierre Ronco

Department of Electrical and Computer Engineering: Faculty Publications

Introduction: Minimal change disease (MCD) and membranous nephropathy (MN) are glomerular diseases (glomerulonephritis [GN]) that present with the nephrotic syndrome. Although circulating PLA2R antibodies have been validated as a biomarker for MN, the diagnosis of MCD and PLA2R-negative MN still relies on the results of kidney biopsy or empirical corticosteroids in children. We aimed to identify serum protein biomarker signatures associated with MCD and MN pathogenesis using aptamer-based proteomics.

Methods: Quantitative SOMAscan proteomics was applied to the serum of adult patients with MCD (n = 15) and MN(n = 37) and healthy controls (n = …

Paths To Positivity: Relational Trajectories And Interaction In Positive Stepparent-Stepchild Dyads, Vincent R. Waldron, Dawn O. Braithwaite, Bailey M. Oliver-Blackburn, Brianna L. Avalos

Department of Communication Studies: Faculty Publications

Stepfamilies are inherently complex family systems, marked by change, flexible boundaries, and early conflict. But the developmental pathways by which long-term stepparent relationships become positive require more study. We interviewed 38 stepchildren who had reached adulthood, to understand how their relationships with a stepparent became positive. Four relational trajectories defined these positive relationships: punctuated, consistent positive, progressive incline, and modulated turbulent. Distinctive communicative practices were associated with each trajectory, such as communicating assurances, “siding,” or revelations of character. In addition, the trajectories shared three common processes: responsiveness to stepchild vulnerability, stepparent “adding value” to the family, and maturation/ reframing of …

The Impact Of Sampling Methodology On Soil Bulk Density Measurement By The Clod Method, Aldi J. Airori, Trinity Baker, Judith Turk

Conservation and Survey Division: Faculty and Staff Publications

The clod method is a widely used and accurate bulk density method. However, its use is limited to sampling from soil pits. This study was conducted to: 1) determine whether clods collected from cores provide similar bulk density measurements to those collected from soil pits and 2) evaluate the impact of various clod bulk density methods on carbon stock calculation. Clods were collected from soil pits, 5.1 cm soil cores, and 8.9 cm soil cores. Three-dimensional laser scanning was used to measure the volume of the soil clods before and after oven-drying and bulk density was calculated as the dry …

Death Scene Insect Succession In Nebraska: A Guidebook, Erin Bauer, Larry Barksdale, Emma Sidel, Justine Laviolette

Department of Entomology: Faculty Publications

Insect behavior can be helpful to law enforcement in determining time of death, manner of death, location, and environment related to human or other animal victims found at a death scene. They may also provide clues about other aspects associated with an investigation (i.e., fly specks, suspect DNA). The study of how insects and related arthropods can aid in legal investigations is known as forensic entomology. Although this includes both civil applications, such as urban (i.e., maggots in mortuaries or insect structural damage) or stored product (i.e., illness from food contamination) entomology, this manual focuses on criminal applications, such as …

Reduced Susceptibility Of Western Corn Rootworm (Diabrotica Virgifera Virgifera Leconte) Populations To Cry34/35ab1‑Expressing Maize In Northeast Nebraska, Jordan D. Reinders, Lance J. Meinke

Department of Entomology: Faculty Publications

The western corn rootworm (WCR; Diabrotica virgifera virgifera LeConte) is a significant pest of maize (Zea mays L.) across the United States Corn Belt. Transgenic maize hybrids expressing insecticidal proteins derived from Bacillus thuringiensis (Bt) have been used to manage WCR since 2003. Widespread resistance to Cry3Bb1 (and associated cross-resistance to mCry3A and eCry3.1Ab) has placed increased selection pressure on Cry34/35Ab1 in single-protein and pyramided transgenic maize hybrids. Data on the susceptibility of Nebraska WCR populations to Cry34/35Ab1 has not been published since 2015 and plant-based bioassays conducted in 2017–2018 confirmed resistance to Cry3Bb1 + Cry34/35Ab1 maize, suggesting resistance …

Production Of Bovine Colostrum For Human Consumption To Improve Health, Merve Kaplan, Ayşenur Arslan, Hatice Duman, Melda Karyelioğlu, Barış Baydemir, Bilgetekin Burak Günar, Merve Alkan, Ayşe Bayraktar, Halil İbrahim Tosun, Melih Ertürk, Günay Eskici, Rebbeca M. Duar, Bethany M. Henrick, Steven A. Frese, Sercan Karav

Department of Food Science and Technology: Faculty Publications

Colostrum contains all essential nutrients for the neonate during the first days of life, with impacts that continue far beyond these first days. Bovine colostrum has been used for human consumption due to the high concentrations of bioactive proteins, vitamins, minerals, growth factors, as well as free and conjugated oligosaccharides. Processes involved in the preparation of bovine colostrum for human consumption play a pivotal role in preserving and maintaining the activity of the bioactive molecules. As bovine colostrum is a multifunctional food that offers a myriad of benefits for human health, assessing the main processes used in preparing it with …

The Agricultural Genome To Phenome Initiative (Ag2pi): Creating A Shared Vision Across Crop And Livestock Research Communities, Christopher Tuggle, Jennifer Clarke, Jack C. M. Dekkers, David Ertl, Carolyn J. Lawrence-Dill, Eric Lyons, Brenda M. Murdoch, Nicole M. Scott, Patrick S. Schnable

Department of Food Science and Technology: Faculty Publications

Predicting phenotype from genotype is a central challenge in biology. By understanding genomic information to predict and improve traits, scientists can address the challenges and opportunities of achieving sustainable genetic improvement of complex, economically important traits in agriculturally relevant species. Converting the enormous, recent technical advances in all areas of genomics and phenomics into sustained and ecologically responsible improvements in food and fuel production is complex. It will require engaging agricultural genome to phenome (G2P) experts, drawing from a broad community, including crop and livestock scientists and essential integrative disciplines (e.g., engineers, economists, data and social scientists). To achieve this …

Adverse Childhood Experiences Exacerbate The Association Between Day-To-Day Discrimination And Mental Health Symptomatology In Undergraduate Students, Emily C. Helminen, Jillian R. Scheer, Katie Edwards, Joshua C. Felver

Department of Educational Psychology: Faculty Publications

Background: Background: Background: Adverse childhood experiences (ACEs) and day-to-day discrimination (hereafter, “discrimination”) both contribute to mental health symptomatology in young adulthood, but how these constructs interact and whether they are associated with mental health remains unclear. This study evaluated whether the relation between discrimination in young adulthood and mental health symptomatology varied as a function of ACEs exposure.

Methods: Undergraduates (n = 251) completed self-report measures related to ACEs, discrimination, and mental health symptomatology (i.e., depression, anxiety, somatization, and psychological distress). Linear and logistic regression models were implemented to test for potential exacerbation effects of ACEs on the relation between …

Improving Social Norms And Actions To Prevent Sexual And Intimate Partner Violence: A Pilot Study Of The Impact Of Green Dot Community On Youth, Victoria L. Banyard, Katie M. Edwards, Andrew J. Rizzo, Emily F. Rothman, Patricia Greenberg, Megan C. Kearns

Department of Educational Psychology: Faculty Publications

Sexual violence (SV) and intimate partner violence (IPV), which often cooccur with bullying, are serious public health issues underscoring the need for primary prevention. The purpose of this study was to examine the impact of a community-building SV and IPV prevention program, Green Dot Community, on adolescents’ perceptions of community social norms and their propensity to intervene as helpful actionists using two independent data sources. Green Dot Community takes place in towns and aims to influence all town members to prevent SV and IPV by addressing protective factors (i.e., collective efficacy, positive prevention social norms, and bystander helping, or actionism). …

Gender Differences In Information Literacy Self-Efficacy Among Academic Librarians In Federal University Libraries In South-East Nigeria, Osita Victor Ossai Dr

Library Philosophy and Practice (e-journal)

The study investigated gender differences in information literacy self-efficacy among academic librarians working in federal university libraries in South-east Nigeria. The descriptive survey research design was used in this study. Using purposive sampling, twenty academic librarians were selected for the study. The Information Literacy Self-Efficacy Scale (ILSES) was used to obtain the data. In total, there are 28 items on the scale, which has a high Cronbach Alpha reliability score of 0.91. In this scale, seven sub-dimensions are measured extensively. To analyze the data, percentages, means, standard deviations, t-tests, and Lavene's tests were used. In terms of mean ratings, male …

Internet Use By Ug Students Of Dr.M.G.R. Fisheries College And Research Institution, Thalainayeru, Tamilnadu, India., Prakasha S N Mr, Veerabasavaiah M Prof.

Library Philosophy and Practice (e-journal)

The present study is focused on Internet use among UG students of Dr.M.G.R. Fisheries and research Institute at Thalainayeru, Tamil Nadu state. A well-structured questionnaire was distributed among 120 students under this study, there are (90.83%) students were responded to the questionnaires. The questionnaires were analyzed according to the objective of the present study such as: To understand knowledge and skills on the internet among students, To know the availability of Internet facility, To find out the frequency of Internet Access, To identify the purpose of Internet use, To know the adequacy of E-resources collection, To verify the …

Determinants Of Virus Variation, Evolution, And Host Adaptation, Katherine Latourrette, Hernan Garcia-Ruiz

Nebraska Center for Virology: Faculty Publications

Virus evolution is the change in the genetic structure of a viral population over time and results in the emergence of new viral variants, strains, and species with novel biological properties, including adaptation to new hosts. There are host, vector, environmental, and viral factors that contribute to virus evolution. To achieve or fine tune compatibility and successfully establish infection, viruses adapt to a particular host species or to a group of species. However, some viruses are better able to adapt to diverse hosts, vectors, and environments. Viruses generate genetic diversity through mutation, reassortment, and recombination. Plant viruses are exposed to …

Immunogenicity And Protective Efficacy Of A Recombinant Pichinde Viral-Vectored Vaccine Expressing Influenza Virus Hemagglutinin Antigen In Pigs, Sushmita Kumari, Jayeshbhai Chaudhari, Qinfeng Huang, Phillip Gauger, Marcelo Nunes De Almeida, Yuying Liang, Hinh Ly, Hiep Vu

Nebraska Center for Virology: Faculty Publications

Influenza A virus of swine (IAV-S) is an economically important swine pathogen. The IAV-S hemagglutinin (HA) surface protein is the main target for vaccine development. In this study, we evaluated the feasibility of using the recombinant tri-segmented Pichinde virus (rPICV) as a viral vector to deliver HA antigen to protect pigs against IAV-S challenge. Four groups of weaned pigs (T01–T04) were included in the study. T01 was injected with PBS to serve as a non-vaccinated control. T02 was inoculated with rPICV expressing green fluorescence protein (rPICV-GFP). T03 was vaccinated with rPICV expressing the HA antigen of the IAV-S H3N2 strain …

Malaria Resilience In South America: Epidemiology, Vector Biology, And Immunology Insights From The Amazonian International Center Of Excellence In Malaria Research Network In Peru And Brazil, Kathrine Torres, Marcelo U. Ferreira, Marcia C. Castro, Ananias A. Escalante, Jan E. Conn, Elizabeth Villasis, Maisa Da Silva Araujo, Gregorio Almeida, Priscila T. Rodrigues, Rodrigo M. Corder, Anderson R.J. Fernandes, Priscila R. Calil, Winni A. Ladeia, Stefano S. Garcia-Castillo, Joaquin Gomez, Lis Ribeiro Do Valle Antonelli, Ricardo T. Gazzinelli, Douglas T. Golenbock, Alejandro Llanos-Cuentas, Dionicia Gamboa, Joseph M. Vinetz

Harold W. Manter Laboratory of Parasitology: Library Materials

The 1990s saw the rapid reemergence of malaria in Amazonia, where it remains an important public health priority in South America. The Amazonian International Center of Excellence in Malaria Research (ICEMR) was designed to take a multidisciplinary approach toward identifying novel malaria control and elimination strategies. Based on geographically and epidemiologically distinct sites in the Northeastern Peruvian and Western Brazilian Amazon regions, synergistic projects integrate malaria epidemiology, vector biology, and immunology. The Amazonian ICEMR’s overarching goal is to understand how human behavior and other sociodemographic features of human reservoirs of transmission— predominantly asymptomatically parasitemic people—interact with the major Amazonian malaria …

Using Political Psychology To Understand Populism, Intellectual Virtues, And Democratic Backsliding, Ingrid J. Haas

Department of Political Science: Faculty Publications

Political scientists have argued that populism is an ideology that can occur on both the left and right, whereby people begin to see politics as a battle between the people and a powerful elite that fails to represent the people’s interest and are attracted to political candidates who vow to fight corruption. In this chapter, I examine how research in political psychology may help to explain the motivations underlying citizens’ attraction to populist ideologies and political candidates. I argue that the same cognitive processes driving people toward populism are those that undermine the intellectual virtues, which in turn, decreases support …

The Evolution Of Quantitative Sensitivity, Margaret A H Bryer, Sarah E. Koopman, Jessica F. Cantlon, Steven T. Piantadosi, Evan L. Maclean, Joseph M. Baker, Michael J. Beran, Sarah M. Jones, Kerry E. Jordan, Salif Mahamane, Andreas Nieder, Bonnie M. Perdue, Friederike Range, Jeffrey R. Stevens, Masaki Tomonaga, Dorottya Ujfalussy, Jennifer Vonk

Jeffrey Stevens Publications

The ability to represent approximate quantities appears to be phylogenetically widespread, but the selective pressures and proximate mechanisms favouring this ability remain unknown. We analysed quantity discrimination data from 672 subjects across 33 bird and mammal species, using a novel Bayesian model that combined phylogenetic regression with a model of number psychophysics and random effect components. This allowed us to combine data from 49 studies and calculate the Weber fraction (a measure of quantity representation precision) for each species. We then examined which cognitive, socioecological and biological factors were related to variance in Weber fraction. We found contributions of phylogeny …

Evaluation Of Ivermectin Antiviral Activity Against Avian Infectious Bronchitis Virus Using A Chicken Embryo Model, Donald L. Reynolds, E. Barry Simpson

School of Veterinary and Biomedical Sciences: Faculty Publications

Ivermectin is widely used in both animals and humans as an FDA-approved parasiticide. Ivermectin has also been reported to have antiviral activity against several viruses including coronaviruses. There are reports that indicate ivermectin may have some role in diminishing the disease caused by SARS-CoV-2, but the evidence is inconclusive. The objective of this study was to determine if ivermectin was efficacious in inhibiting avian infectious bronchitis virus (IBV, a coronavirus) replication in chicken embryos. Briefly, our approach was to use the Massachusetts vaccine strain of IBV in combination with various doses of ivermectin and then inoculate these preparations into chicken …

Structural Variant-Based Pangenome Construction Has Low Sensitivity To Variability Of Haplotype-Resolved Bovine Assemblies, Alexander S. Leonard, Danang Crysnanto, Zih-Hua Fang, Michael P. Heaton, Brian L. Vander Ley, Carolina Herrera, Heinrich Bollwein, Derek M. Bickhart, Benjamin D. Rosen, Hubert Pausch

School of Veterinary and Biomedical Sciences: Faculty Publications

Advantages of pangenomes over linear reference assemblies for genome research have recently been established. However, potential effects of sequence platform and assembly approach, or of combining assemblies created by different approaches, on pangenome construction have not been investigated. Here we generate haplotype-resolved assemblies from the offspring of three bovine trios representing increasing levels of heterozygosity that each demonstrate a substantial improvement in contiguity, completeness, and accuracy over the current Bos taurus reference genome. Diploid coverage as low as 20x for HiFi or 60x for ONT is sufficient to produce two haplotype-resolved assemblies meeting standards set by the Vertebrate Genomes Project. …

Does Swab Type Matter? Comparing Methods For Mannheimia Haemolytica Recovery And Upper Respiratory Microbiome Characterization In Feedlot Cattle, William B. Crosby, Lee Pinnell, John T. Richeson, Cory Wolfe, Jake Castle, John Dustin Loy, Sheryl P. Gow, Keun Seok Seo, Sarah F. Capik, Amelia R. Woolums, Paul S. Morley

School of Veterinary and Biomedical Sciences: Faculty Publications

Background: Bovine respiratory disease (BRD) is caused by interactions among host, environment, and pathogens. One standard method for antemortem pathogen identification in cattle with BRD is deep-guarded nasopharyngeal swabbing, which is challenging, costly, and waste generating. The objective was to compare the ability to recover Mannheimia haemolytica and compare microbial community structure using 29.5 inch (74.9 cm) deep-guarded nasopharyngeal swabs, 16 inch (40.6 cm) unguarded proctology swabs, or 6 inch (15.2 cm) unguarded nasal swabs when characterized using culture, real time-qPCR, and 16S rRNA gene sequencing. Samples for aerobic culture, qPCR, and 16S rRNA gene sequencing were collected from the …

Rna Nanovaccine Protects Against White Spot Syndrome Virus In Shrimp, Yashdeep Phanse, Supraja Puttamreddy, Duan Loy, Julia Vela Ramirez, Kathleen A. Ross, Ignacio Alvarez-Castro, Mark Mogler, Scott Broderick, Krishna Rajan, Balaji Narasimhan, Lyric C. Bartholomay

School of Veterinary and Biomedical Sciences: Faculty Publications

In the last 15 years, crustacean fisheries have experienced billions of dollars in economic losses, primarily due to viral diseases caused by such pathogens as white spot syndrome virus (WSSV) in the Pacific white shrimp Litopenaeus vannamei and Asian tiger shrimp Penaeus monodon. To date, no effective measures are available to prevent or control disease outbreaks in these animals, despite their economic importance. Recently, double-stranded RNA-based vaccines have been shown to provide specific and robust protection against WSSV infection in cultured shrimp. However, the limited stability of double-stranded RNA is the most significant hurdle for the field application of these …