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The Longitudinal Influence Of Adhd Status And Stimulant Medication On Body Mass Index And Blood Pressure Among Obese Youth, Sophie Kollin

Electronic Theses and Dissertations

Youth with attention-deficit hyperactivity disorder (ADHD) are more vulnerable to developing obesity, as they have significantly higher body mass index (BMI) and are at increased risk of food addiction and binge eating. Stimulant medication use, which is an evidence-based treatment for ADHD, is associated with lower BMI and higher blood pressure among normal weight youth. The purpose of this study was to examine the longitudinal influence of ADHD and stimulant medication use on BMI and blood pressure trajectories among a sample of 456 youth treated in a weight management clinic. Mixed linear modeling examined the main and interactive effects of …

Amphiphilic Janus Polymer Nanoparticles For Pharmaceutical And Biomedical Applications, Mahesh Loku Yaddehige

Electronic Theses and Dissertations

Amphiphilic hybrid polymers have attracted significant interest as biomaterials for both fundamental research and practical clinical applications due to their unique polymer structure and properties relative to the conventional symmetric polymers. Often referred to as “Janus” polymers combine two different polymer segments (hydrophilic and hydrophobic) of varying degrees, sizes, and functionalities to obtain a single amphiphilic or hetero-functional macromolecule with characteristic features. In particular, amphiphilic “Janus” polymers and their self-assemblies have shown apparent success in nanomedicine owing to their ability to provide highly ordered nanoscale multimolecular aggregates, including micelles and vesicles. However, engineering these polymeric materials on a large scale …

Halogen Bond Driven Supramolecular Materials, Dilan Chinthaka Karunathilaka

Electronic Theses and Dissertations

Halogen bonding (XBing) is a type of non-covalent interaction between covalently bound halogen atoms (XB donor), and Lewis bases (XB acceptor). In recent years, it has become a remarkable and adaptable tool to produce interesting molecular architectures and functionalities in organic-based materials. Such applications include liquid crystals, nonlinear optics, photovoltaics, and multicolor displays in the solid phase. Due to this variety of applications, XBing has become an exciting area of study in supramolecular chemistry. Herein are presented synthetic routes and characterization of self-assembling XBing molecules and their resulting materials. First, four different heterocyclic oligomers containing pyrazine, thiophene, and furan have …

Botanical Aphrodisiacs For Women's Health, Hayley N. Prescott

Electronic Theses and Dissertations

Female Sexual Dysfunction (FSD) affects nearly 40% of women in the United States. While males have five FDA approved drugs for ED, there is only one FDA-approved as-needed treatment for premenopausal women with acquired, generalized Hypoactive Sexual Desire Disorder (HSDD), the most prevalent FSD. The lack of approved drugs is largely due to the biopsychosocial complexity of HSDD; however, there are neurobiological underpinnings evident. Due to the lack of safe efficacious treatment options, we hypothesize that botanical species traditionally used as aphrodisiacs may be promising leads, and exert their effects via activation of melanocortin’s, an excitatory circuit implicated in sexual …

Perceptions Of English Learner Support Provided By K-12 Leaders To Educators In Mississippi, Ladonna Thomas

Electronic Theses and Dissertations

The demographic of public schools in America is continuously changing. According to the United States Department of Education (USDE), the English learner population increased in over 25 states from the 2009-2010 school year to the 2014-2015 school year (USDE, 2017). In 2014-15, there were more than 4,800,000 English learners enrolled in schools, accounting for 10% of the total student population (USDE, 2017). With this shifting demographic, educators must be prepared to meet the needs of EL students.

The purpose of this study is to examine educators and instructional leaders’ perceptions of EL instructional support and to highlight the need for …

Making The Equal Rights Amendment That Is Needed In The Twenty-First Century, Julie Suk

Faculty Scholarship

No abstract provided.

Microglia Distribution In The Lateral Ventricles Following Treatment Of Lysolecithin Model Of Multiple Sclerosis, Spencer James Wilson

Browse all Theses and Dissertations

Multiple sclerosis (MS) affects an estimated one million people in the US alone (Wallin et al., 2019). We modeled MS in rats using lysolecithin injection into the corpus callosum to diminish motor function unilaterally through demyelination, meanwhile treating the injury with Fluoxetine, Ibuprofen, and ascorbic acid (FIAA) to increase neurogenesis and oligodendrogenesis. Motor function was assessed using the Montoya Staircase test pre- and post-surgery. Motor capabilities recovered in the contralateral limb, but not in the ipsilateral, and recovery was not significantly affected by treatment. We identified microglia by CX3CR1 and examined its distribution in the adult neurogenic niche, the SVZ …

Radial Artery Model For Catheterization Procedures, Kyla Beville, Mitchell Gagnon, Benjamin Stalls, Maya Ariza

Williams Honors College, Honors Research Projects

The purpose of this project was to create a radial artery model that is usable under ultrasound that would reduce complications during catheterization procedures. Each year, over one million of these procedures are done and complications can affect the outcomes of the patient. Using ultrasound during these procedures is an upcoming way to reduce these complications and improve the outcome that a patient will have.

Glacial Deposits, Vol. 47, 2022, Department Of Geography, Geology, And The Environment

Glacial Deposits

Newsletter of the Department of Geography, Geology, and the Environment

Escherichia Coli In Lake Erie: Impact On Lake Health, Mary Grmek

Williams Honors College, Honors Research Projects

Lake Erie is a vital resource for its surrounding area, and one of its most important purposes is as a recreational body of water. In determining whether Lake Erie’s water quality meets U.S. EPA standards, daily surveys and water samples were taken on behalf of the Lake County General Health District, as well as E. coli samples every other day. This paper quantified the E. coli count for both Mentor Headlands Beach and Fairport Harbor Beach in Lake County over the swimming seasons for 2020 and 2021, as well as evaluated which variables collected in daily surveys impact E. coli …

Genomic Instability At A Polypurine/Polypyrimidine Repeat Sequence, Nathen S. Zavada

Browse all Theses and Dissertations

Microsatellite repeat sequences have been shown to induce replication stalling, fork collapse, double-strand breaks (DSBs), and possibly stimulate break-induced replication. In this study we use a dual-fluorescent HeLa model that is designed to monitor recombination at an ectopic site through use of flow cytometry and inverse PCR with a microsatellite in the lagging strand for DNA synthesis. To test the stability of the 78 bp polypurine/pyrimidine repeat from the PDK1 locus, we subjected cells to replication stress drugs designed to induce DSBs and measure break-induced replication (BIR). The study revealed that polypurine repeat cells undergo endogenous stress contributing to instability …

A Solder-Defined Computer Architecture For Backdoor And Malware Resistance, Marc W. Abel

Browse all Theses and Dissertations

This research is about securing control of those devices we most depend on for integrity and confidentiality. An emerging concern is that complex integrated circuits may be subject to exploitable defects or backdoors, and measures for inspection and audit of these chips are neither supported nor scalable. One approach for providing a “supply chain firewall” may be to forgo such components, and instead to build central processing units (CPUs) and other complex logic from simple, generic parts. This work investigates the capability and speed ceiling when open-source hardware methodologies are fused with maker-scale assembly tools and visible-scale final inspection.

The …

Amino-Polymer For Co2 Capture By Vacuum Swing Adsorption, Sean Billy

Williams Honors College, Honors Research Projects

The applications of sorbent compounds in conjunction with amines and other additives is an innovative method at combating CO2 pollution. An ideal solution would use an amine sorbent to trap the high levels of absorbed CO2 with a low binding energy (less than 45 kJ/mol) and subsequently release them into a stored vessel at ambient temperature with a vacuum swing adsorption system. Attempts at finding a best mixture will be conducted through the usage of a vacuum swing system, utilizing a bed syringe containing the sorbent mix and a vacuum syringe to pull on and subsequently release the CO2 into …

Investigation Of Casting Methods Of Photoelastic Particles To Study The Geomechanics Of Granular Media, Daniel Schullek

Williams Honors College, Honors Research Projects

The research being conducted within this project is to observe force chains in different samples of soil media with varying shapes. The method for observing the force chains is a process called photoelasticity. Photoelasticity uses two polarizing sheets, with the clear media being tested placed between, and light is directed through the sheets to observe how the light is refracted as force is applied to the tested media. Through our research, we are coming up with a method of casting soil particles through the utilization of resin, silicone, and 3D printing. Once the clear particles have been cast, we will …

Potential Effects Of Amynthas Agrestis Invasion On Woody Understory Flora In The Cvnp, Christian Mammana

Williams Honors College, Honors Research Projects

Ohio forests are threatened by the invasive ecosystem engineer A. agrestis. A. agrestis invasion typically co-occurs with the ecosystem engineer, Odocoileus virginianus, where their impacts may synergize. To determine the direct effects of A. agrestis invasion, fenced plots across the Cuyahoga Valley National Park that excluded deer were utilized. The species richness, Shannon diversity and evenness of woody understory flora was measured in each plot. Mustard extraction was used to determine earthworm abundance. Correlations between abundance and measured variables were used to highlight potential invasion effects. Abundance and species richness was found to have a significant, positive correlation (p = …

Familial Hypercholesterolemia And Treatments, Alexis Steer

Williams Honors College, Honors Research Projects

My project will be a literature review regarding the genetic mutations associated with

familial hypercholesterolemia and the current available treatments.

Sequential Block Copolymers Of Polyisobutylene And Polyolefins, Manwel Labib

Williams Honors College, Honors Research Projects

A two-step approach will be utilized to synthesize random polyolefin multiblock-copolymers. This strategy takes advantage of a,w-terminated telechelic polyolefins. Polypropylene (iPP)/polyethylene (PE) are picked because of their strength, and polyisobutylene (PIB) because of its hemocompatibility. This copolymer is theorized to make for robust bio-inert plastic, which can be used for surgical mesh implants.

Emergency Water Treatment Methods Through The Adaptation Of Natural Disaster Building Debris, Benjamin Colston

Williams Honors College, Honors Research Projects

The primary objective of this research was to determine whether concrete slag acquired from building debris in a disaster can be utilized to remove pathogens biochemically through changes in pH or physically through filtration. Direct Plate Enumeration testing was completed for different water samples to compare the general activity of bacterial growth as an indication of pathogenic potential. Throughout each experiment, the pH of different water samples was monitored and consistently indicated that water samples in contact with concrete pieces (concrete water samples) would exhibit a higher pH than samples with no exposure to concrete (control water samples). Compared to …

Amygdala Modeling With Context And Motivation Using Spiking Neural Networks For Robotics Applications, Matthew Aaron Zeglen

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Cognitive capabilities for robotic applications are furthered by developing an artificial amygdala that mimics biology. The amygdala portion of the brain is commonly understood to control mood and behavior based upon sensory inputs, motivation, and context. This research builds upon prior work in creating artificial intelligence for robotics which focused on mood-generated actions. However, recent amygdala research suggests a void in greater functionality. This work developed a computational model of an amygdala, integrated this model into a robot model, and developed a comprehensive integration of the robot for simulation, and live embodiment. The developed amygdala, instantiated in the Nengo Brain …

Sportiasts, Yuvraj Subedi

Williams Honors College, Honors Research Projects

Sportiasts is an online platform that connects sports enthusiasts. This platform explores the most recent back-end tool: Django and PostgreSQL to provide sports enthusiasts a platform to connect with each other. This platform is versatile and dynamic for the users to have their best experience connecting with sports communities. Anyone with sports interests can use this application to explore, connect, and create sports communities.

Immunohistochemistry Of The Zebrafish Retina, Alison Ruf

Williams Honors College, Honors Research Projects

The retina is made up of many different essential parts that work together to allow for vision of many different species. Some of these crucial cells and proteins include ganglion cells, bipolar cells, photoreceptors, synaptic markers, such as VGLUT, and receptors that bind glutamate. The basis of this project is to use immunohistochemistry to identify these important aspects of the retina in zebrafish via monoclonal and polyclonal antibodies. The goal being to compare specific cells in a control group retina to an experimental group of zebrafish.

Erk3 And Dgkζ Interact To Modulate Cell Motility In Lung Cancer Cells, Amanda Myers

Browse all Theses and Dissertations

Extracellular-regulated kinase 3 (ERK3) is overexpressed in a variety of cancers, including lung cancer. This atypical mitogen-activated protein kinase (MAPK) has a unique structure which includes a C34 domain and C-terminus and about which relatively little is known. ERK3 has been demonstrated to promote cell migration and metastasis in multiple cancer types. A yeast two-hybrid assay using ERK3 as bait indicated Diacylglycerol kinase ζ (DGKζ) is a binding partner. DGKζ is an isoform in the DGK family, all the members of which phosphorylate the lipid diacylglycerol (DAG) to generate phosphatidic acid (PA). DGKζ was shown to promote migration in mouse …

2022 Dsac High Tunnel Bell Pepper Variety Trial, Bronwyn Aly

Midwest Vegetable Trial Reports

This paper reports on seven bell pepper cultivar entries evaluated in a high tunnel production system during the 2022 growing season at the University of Illinois Dixon Springs Agricultural Center (DSAC) located in southern Illinois (Pope County).

Impacts Of Nitrogen Rate And Source Following Green Manure On Broccoli Yield, Charlie Rohwer

Midwest Vegetable Trial Reports

Cover crops are beneficial to soil structure and processes and can provide nitrogen (N) to a subsequent crop. Practical studies of N availability from cover crops and organic fertilizers in naive (transitioning) soils are helpful for growers to achieve desirable yield. Microbial soil inoculants (biostimulants) may enhance availability of organic N sources. We found a spring-planted pea-oat cover crop provided less than 27 pounds of N to a subsequent broccoli crop, and no impact of a commercial biostimulant on broccoli yield or development rate. Availability of N from organic amendments used is discussed.

2022 High Tunnel Fresh Market Determinate Tomato Cultivar Trial For Southern Illinois, Bronwyn Aly

Midwest Vegetable Trial Reports

A determinate tomato cultivar trial was conducted at the University of Illinois Dixon Springs Agricultural Center (DSAC) located in southern Illinois (Pope County) during the 2022 growing season. The objective of this trial was to compare performance of thirteen fresh market determinate tomato cultivars in a high tunnel production system.

Reflecting On Recurring Failures In Iot Development, Dharun Anandayuvaraj, James C. Davis

Department of Electrical and Computer Engineering Faculty Publications

As IoT systems are given more responsibility and autonomy, they offer greater benefits, but also carry greater risks. We believe this trend invigorates an old challenge of software engineering: how to develop high-risk software-intensive systems safely and securely under market pressures? As a first step, we conducted a systematic analysis of recent IoT failures to identify engineering challenges. We collected and analyzed 22 news reports and studied the sources, impacts, and repair strategies of failures in IoT systems. We observed failure trends both within and across application domains. We also observed that failure themes have persisted over time. To alleviate …

Computational Fluid Dynamics Modeling Of A Broiler House Microclimate In Summer And Winter, Erdem Küçüktopcu, Bilal Cemek, Halis Simsek, Ji-Qin Ni

School of Agricultural & Biological Engineering Faculty Publications

Appropriate microclimate conditions in broiler housing are critical for optimizing poultry production and ensuring the health and welfare of the birds. In this study, spatial variabilities of the microclimate in summer and winter seasons in a mechanically ventilated broiler house were modeled using the computational fluid dynamics (CFD) technique. Field measurements of temperature, relative humidity, and airspeeds were conducted in the house to compare the simulated results. The study identified two problems of high temperature in summer, which could result in bird heat stress and stagnant zones in winter, and simulated possible alternative solutions. In summer, if an evaporative cooling …

Gravity Dependence Quantifiers For Vapor Compression Cycles Subjected To Inclination Testing And Parabolic Flights, Leon P. M. Brendel, Stephen L. Caskey, James E. Braun, Eckhard A. Groll

International Refrigeration and Air Conditioning Conference

No abstract provided.

Extraction Of Melanin From Black Knot Fungus: Optimization And Applications, Amara Davis

Williams Honors College, Honors Research Projects

The goal of this research project was to optimize the extraction of melanin from black knot fungus and to analyze possible applications of the extracted melanin. An extraction method that was previously created was examined for possible improvements. Improvements that were studied include the elimination of steps in the extraction process while obtaining the same quality of product, examining options for machinery that could be used to increase production rate when moved to a production plant setting, and optimize the concentrations of the raw materials that are used in the extraction for possible reduction of cost without compromising yield or …

Retaining Thermoresponsive Poly(Vinyl Methyl Ether) To Cellulose Via (3-Aminopropyl)Triethoxylsilane Network, Grace Tolhurst

Williams Honors College, Honors Research Projects

Stimuli-responsive supports and devices that are fabricated from inexpensive materials are attractive candidates for a variety of applications, such as environmental protection, and regenerative medicine. Poly(vinyl methyl ether) (PVME), a thermoresponsive polymer (TRP), has recently been used as thermoresponsive cell culture supports for cell growth/proliferation followed with cell/cell sheet harvesting by simply switching temperature. Cellulose is an attractive candidate to replace glass/silicone supports as it is inexpensive and environmentally friendly. This project focuses on retaining PVME to the cellulose membrane via 3-aminopropyltriethoxysilane (APTES) network to generate TR membranes and flexible liners that can be incorporated into bioreactors for producing cells …