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Enlightening The Molecular Mechanisms Of Type 2 Diabetes With A Novel Pathway Clustering And Pathway Subnetwork Approach, Burcu Güngör, Mi̇ray Ünlü Yazici, Gökhan Göy, Mustafa Temi̇z Jan 2022

Enlightening The Molecular Mechanisms Of Type 2 Diabetes With A Novel Pathway Clustering And Pathway Subnetwork Approach, Burcu Güngör, Mi̇ray Ünlü Yazici, Gökhan Göy, Mustafa Temi̇z

Turkish Journal of Biology

Type 2 diabetes mellitus (T2D) constitutes 90% of the diabetes cases, and it is a complex multifactorial disease. In the last decade, genome-wide association studies (GWASs) for T2D successfully pinpointed the genetic variants (typically single nucleotide polymorphisms, SNPs) that associate with disease risk. In order to diminish the burden of multiple testing in GWAS, researchers attempted to evaluate the collective effects of interesting variants. In this regard, pathway-based analyses of GWAS became popular to discover novel multigenic functional associations. Still, to reveal the unaccounted 85 to 90% of T2D variation, which lies hidden in GWAS datasets, new post-GWAS strategies need …


Demethylase Fto Inhibits The Development Of Prostate Cancer By Upregulating Egr2 Expression In An M6a Manner, Zhenyu Wang, Huami̇n Sun, Hua Zhu, Donghua Gu, Xi̇nfeng Chen, Yongsheng Pan, Bi̇ng Zheng, Dongrong Yang Jan 2022

Demethylase Fto Inhibits The Development Of Prostate Cancer By Upregulating Egr2 Expression In An M6a Manner, Zhenyu Wang, Huami̇n Sun, Hua Zhu, Donghua Gu, Xi̇nfeng Chen, Yongsheng Pan, Bi̇ng Zheng, Dongrong Yang

Turkish Journal of Biology

Fat mass and obesity-associated protein (FTO) is a demethylase and plays a vital role in various cancers. However, the regulation mechanism of FTO in prostate cancer (PCa) remains unclear. This study aimed to elucidate the mechanism of FTO in PCa. The function and mechanism of FTO-mediated in PCa were determined by gain-of-function assays and RNA-seq. We found that FTO expression in PCa tissues and two PCa cell lines were significantly lower than that in adjacent tissues and normal cell line. PCa cells after overexpression of FTO showed a significant lower in proliferation, migration, and invasion capabilities. RNA-seq displayed that FTO …


Vars1 Mutations Associated With Neurodevelopmental Disorder Are Located On A Short Amino Acid Stretch Of The Anticodon-Binding Domain, Ayşe Semra Hiz, Seval Kiliç, Güney Bademci̇, Tülay Karakulak, Aybi̇ke Erdoğan, Burcu Özden Yücel, Çi̇ğdem Eresen Yazicioğlu, Şeri̇fe Esra Erdal Bağriyanik, Uluç Yi̇ş, Mustafa Teki̇n, Gökhan Karakülah, Ezgi̇ Karaca Erek, Mehmet Öztürk Jan 2022

Vars1 Mutations Associated With Neurodevelopmental Disorder Are Located On A Short Amino Acid Stretch Of The Anticodon-Binding Domain, Ayşe Semra Hiz, Seval Kiliç, Güney Bademci̇, Tülay Karakulak, Aybi̇ke Erdoğan, Burcu Özden Yücel, Çi̇ğdem Eresen Yazicioğlu, Şeri̇fe Esra Erdal Bağriyanik, Uluç Yi̇ş, Mustafa Teki̇n, Gökhan Karakülah, Ezgi̇ Karaca Erek, Mehmet Öztürk

Turkish Journal of Biology

Majority of 37 human aminoacyl tRNA synthetases have been incriminated in diverse, mostly recessive, genetic diseases. In accordance with this, we uncovered a novel homozygous valyl-tRNA synthetase 1 (VARS1) gene variant, leading to p.T1068M mutation. As in the previously reported VARS1 mutations, the affected individual harboring p.T1068M was experiencing a neurodevelopmental disorder with intractable seizures, psychomotor retardation, and microcephaly. To link this phenotypic outcome with the observed genotype, we structurally modeled human VARS1 and interpreted p.T1068M within the spatial distribution of previously reported VARS1 variants. As a result, we uncovered that p.T1068M is clustered with three other pathogenic …


Inhibition Of Trpv4 Attenuates Ferroptosis Against Lps-Induced Ali Via Ca2+ Pathway, Junying Cai, Guohai Xu, Yue Lin, Bin Zhou, Zhenzhong Luo, Shuchun Yu, Jun Lu Jan 2022

Inhibition Of Trpv4 Attenuates Ferroptosis Against Lps-Induced Ali Via Ca2+ Pathway, Junying Cai, Guohai Xu, Yue Lin, Bin Zhou, Zhenzhong Luo, Shuchun Yu, Jun Lu

Turkish Journal of Biology

Acute lung injury (ALI) is an inflammation of the lungs with high incidence rate and mortality. Ferroptosis is a new cell death, which has influence in body organs. Transient receptor potential vanillin-4 (TRPV4) channel is a key mediator of Ca2+, its activation induces ferroptosis. The purpose of the study is to investigate the function of TRPV4 on ferroptosis in ALI mice induced by lipopolysaccharide (LPS). In vitro, the regulation of TRPV4 on Ca2+ and ferroptosis was detected by CCK-8, fluorescent probe, and western blot in BEAS-2B cells. In vivo, the role of TRPV4 antagonists on ALI mice …


Scaffolds From Medical Grade Chitosan: A Good Choice For 3d Cultivation Of Mesenchymal Stem Cells, Merve Çapkin Yurtsever, Özge Eki̇n Akdere, Menemşe Gümüşdereli̇oğlu Jan 2022

Scaffolds From Medical Grade Chitosan: A Good Choice For 3d Cultivation Of Mesenchymal Stem Cells, Merve Çapkin Yurtsever, Özge Eki̇n Akdere, Menemşe Gümüşdereli̇oğlu

Turkish Journal of Biology

Chitosan has high biocompatibility, supports proliferation of many cells, and can be a good carrier for various growth factors. However, low attachment ratio and spheroid formation of several stem cell types on plain chitosan scaffolds/films is still a problem. In this study, it was aimed to obtain 3D scaffolds using medical grade chitosan (MC) with a high deacetylation degree (DD ≥ 92.6%) to overcome the spheroid formation of rat adipose tissue derived mesenchymal stem cells (rAdMSCs) on control chitosan (C, DD = 75%-85%) scaffolds. Genipin was used as a biological chemical crosslinker, and glycerol phosphate salt was used both as …


Knockdown Of Death Receptor 5 Antisense Long Noncoding Rna And Cisplatin Treatment Modulate Similar Macromolecular And Metabolic Changes In Hela Cells, Di̇lek Cansu Gürer, İpek Erdoğan Vatansever, Çağatay Ceylan, Bünyami̇n Akgül Jan 2022

Knockdown Of Death Receptor 5 Antisense Long Noncoding Rna And Cisplatin Treatment Modulate Similar Macromolecular And Metabolic Changes In Hela Cells, Di̇lek Cansu Gürer, İpek Erdoğan Vatansever, Çağatay Ceylan, Bünyami̇n Akgül

Turkish Journal of Biology

Background/aim: Despite great progress in complex gene regulatory mechanisms in the dynamic tumor microenvironment, the potential contribution of long noncoding RNAs (lncRNAs) to cancer cell metabolism is poorly understood. Death receptor 5 antisense (DR5-AS) is a cisplatin inducible lncRNA whose knockdown modulates cell morphology. However, its effect on cell metabolism is unknown. The aim of this study is to examine metabolic changes modulated by cisplatin and DR5-AS lncRNA in HeLa cells. Materials and methods: We used cisplatin as a universal cancer therapeutic drug to modulate metabolic changes in HeLa cervix cancer cells. We then examined the extent of metabolic changes …


Data Driven Approach To Saltwater Disposal (Swd) Well Location Optimization In North Dakota, Kalyanaraman Venugopal Jan 2022

Data Driven Approach To Saltwater Disposal (Swd) Well Location Optimization In North Dakota, Kalyanaraman Venugopal

Theses and Dissertations

The sharp increase in oil and gas production in the Williston Basin of North Dakota since 2006 has resulted in a significant increase in produced water volumes. Primary mechanism for disposal of produced water is by injection into underground Inyan Kara formation through Class-II Saltwater Disposal (SWD) wells. With number of SWD wells anticipated to increase from 900 to over 1400 by 2035, localized pressurization and other potential issues that could affect performance of future oil and SWD wells, there was a need for a reliable model to select locations of future SWD wells for optimum performance. Since it is …


Non-Binary Gender Identity Development: A Qualitative Study, Trevor Waagen Jan 2022

Non-Binary Gender Identity Development: A Qualitative Study, Trevor Waagen

Theses and Dissertations

Gender identity development models in psychology for transgender individuals have typically combined the experiences of binary transgender and non-binary transgender people into the same group. However, differences may exist between the two communities. Therefore, the present study sought to explore the lived experiences of non-binary adults and their gender identity development process. Through the lens of grounded theory (Charmaz, 2014), semi-structured, qualitative interviews were conducted with 10 non-binary participants to collect rich data on their gender identity development process. Transcriptions were coded and reviewed to develop themes and categories. The themes included: Connection and relationships, intersectionality and culture, gender in …


Animals May Be More Reliably Emotional Than Humans, Gerben A. Van Kleef Jan 2022

Animals May Be More Reliably Emotional Than Humans, Gerben A. Van Kleef

Animal Sentience

Despite considerable advances in the study of animal sentience, reluctance to credit non-human animals with emotional capacities persists. I argue that this reluctance is untenable in light of (evolutionary) theory and empirical evidence. Humans may differ from animals in their ability to reflect on, reason about, and deliberately regulate their emotions. If anything, however, this implies animals’ emotional displays provide a more valid and reliable window into their internal states than do humans’, whose displays may be strategically altered. Any signs of pleasure or distress thus constitute direct readouts of animal wellbeing. It is time we start treating animals accordingly.


Looking Upstream For Factors Influencing Mental Illness In A Low-Resource Setting, Adewole Adebola Adefalu Jan 2022

Looking Upstream For Factors Influencing Mental Illness In A Low-Resource Setting, Adewole Adebola Adefalu

Walden Dissertations and Doctoral Studies

An investigation into the upstream determinants of mental disorders could provide insight into pathways by which these risk factors could relate to different groups of mental illness. The study was a quantitative inquiry using constructs within the Rothman’s sufficient and component cause framework to examine the pathways existing between upstream risk factors for schizophrenic and mood disorders. The study population was drawn from a convenience sample of clients accessing services at the psychiatry departments of a secondary mental health institution in North-Central Nigeria. The mean age of the participants in this study was 35.5years. The majority were males (53.4%), single …


Perceptions Of Instructor Caring Behaviors Between English As A Second Language And Non-English As A Second Language Nursing Students, John Chukwuemeka Dike Jan 2022

Perceptions Of Instructor Caring Behaviors Between English As A Second Language And Non-English As A Second Language Nursing Students, John Chukwuemeka Dike

Walden Dissertations and Doctoral Studies

AbstractEnglish as a second language (ESL) nursing students have a significantly higher attrition rate and lower National Council Licensure Examination (NCLEX) pass rate than their non-ESL counterparts. Instructor caring behaviors (ICBs) are the ways nursing instructors treat students with respect, taking care to avoid prejudices, stereotyping, and judgments in the teaching-learning process which present prelicensure faculty to grapple with the challenge of effectively meeting the learning needs of both ESL and non-ESL students. The purpose of this cross-sectional, comparative study, guided by Watson’s theory of human caring, was to explore the differences in perceptions of ICBs between ESL and non-ESL …


General Education Elementary Teacher Competencies And Training In Teaching Children With Autism In The U.S. Virgin Islands, Merle Merinda Elizabeth Durand Jan 2022

General Education Elementary Teacher Competencies And Training In Teaching Children With Autism In The U.S. Virgin Islands, Merle Merinda Elizabeth Durand

Walden Dissertations and Doctoral Studies

The number of students diagnosed with autism spectrum disorder (ASD) is increasing. The overall problem in this study focused on showing how a lack of teacher training in ASD-specific courses could result in a lack of competencies in meeting the educational needs of children with autism in an inclusive setting. The purpose of this nonexperimental quantitative cross-sectional study was to determine if a difference exists in four teaching competencies among general education elementary teachers teaching children with autism in the general education classroom in the U.S. Virgin Islands based training. The theoretical framework was grounded in Medley’s teaching competence theory …


Use Of Evidence-Based Clinical Practice Guidelines In Obesity Management In Women, Chizimako Margaret Eze Jan 2022

Use Of Evidence-Based Clinical Practice Guidelines In Obesity Management In Women, Chizimako Margaret Eze

Walden Dissertations and Doctoral Studies

AbstractObesity is one of the Healthy People 2020 high-priority public health issue. Obesity is of importance due to the troubling higher prevalence in women because of the close link that exists between body weight and reproductive health in females from menarche to menopause and beyond. The identification of guidelines to improve or manage the care of female patients can alleviate the burden and complications from being overweight or obese. This project guided by the ADDIE (analyze, design, develop, implement, and evaluate) model was conducted in a family primary care clinic to address a gap in practice, the lack of knowledge …


The Relationship Of Diversity Education On Perceptions Of Criminal Justice Majors, Deborah Palicia Jan 2022

The Relationship Of Diversity Education On Perceptions Of Criminal Justice Majors, Deborah Palicia

Walden Dissertations and Doctoral Studies

AbstractIn a world of ever-changing demographics, it is imperative that criminal justice practitioners acquire the knowledge and skills needed to effectively interact with the communities they serve. The purpose of this nonexperimental study was to ascertain the relationship between perceptions of diversity of undergraduate criminal justice majors at a Northeastern college who had taken a diversity course to those who had not. Bandura’s social cognitive theory guided this study. Data were collected using McMorris’ Perceptions of Criminality survey with a purposive nonprobability sample of 72 criminal justice majors at a Northeastern college who were 18 years of age or older. …


Phenomenology Of How The Doctor-Patient Relationship Plays A Role In Cardiovascular, Sanam Sarahbi Jan 2022

Phenomenology Of How The Doctor-Patient Relationship Plays A Role In Cardiovascular, Sanam Sarahbi

Walden Dissertations and Doctoral Studies

Cardiovascular disease (CVD) is the leading cause of death in men and women for most racial and ethnic groups in the United States. Physicians are the most frequently sought-after source of support for self-management of chronic diseases of patients. Social support from physicians may help facilitate patient resiliency. This phenomenological study involved using the social support theory as the theoretical lens and health literacy as the conceptual framework to explore how CVD patients perceive experiences with their physicians foster resiliency. Semi-structured interviews were used to collect rich descriptions of CVD patient experiences. Data were analyzed by using Moustakas’ modification of …


Association Between Parental Socioeconomic Status And Childhood Obesity In The Southwest Geopolitical Zone Of Nigeria, Omatsola Aboyowa Sifo Jan 2022

Association Between Parental Socioeconomic Status And Childhood Obesity In The Southwest Geopolitical Zone Of Nigeria, Omatsola Aboyowa Sifo

Walden Dissertations and Doctoral Studies

AbstractGlobally, childhood obesity is a major social and public health concern characterized by complications such as high cholesterol and high blood pressure. The purpose of this quantitative cross-sectional study was to examine the association between childhood obesity in children age 6–12 years and the socioeconomic status of their parents in the Southwest geopolitical zone of Nigeria. Social cognitive theory served as the theoretical framework for the study. Questionnaire data were collected from 384 parents/guardians of children age 6–12 years across three states in the Southwest geopolitical zone of Nigeria. Data were analyzed using descriptive statistics and multiple logistic regression at …


Expectations And Reality: Post Deployment Reintegration Through The Lived Experiences Of Military Spouses, Michele Marie Brown Jan 2022

Expectations And Reality: Post Deployment Reintegration Through The Lived Experiences Of Military Spouses, Michele Marie Brown

Walden Dissertations and Doctoral Studies

This phenomenological study aims to understand how post-deployment reintegration impacted the quality of life, functionality, adjustment, and levels of distress among military spouses. Additionally, this study analyzed data collected from 11 individual military spouse responses to gain firsthand insight into the challenges of post-deployment reintegration and the resiliency factors that influence stability. While extensive research existed on the challenges associated with the hardships of physical distance and absence, there was limited research on the impact of post-deployment reintegration on the overall quality of life of a military spouse. Three theories explored the extremely individualized experiences of military spouses’ post-deployment reintegration. …


Predictors Of Glycemic Control Among Type 2 Diabetes Mellitus Patients In Owerri, Nigeria, Jideuma Ikenna Egwim Jan 2022

Predictors Of Glycemic Control Among Type 2 Diabetes Mellitus Patients In Owerri, Nigeria, Jideuma Ikenna Egwim

Walden Dissertations and Doctoral Studies

Diabetes mellitus (DM) is a significant public health concern globally and in Owerri, Nigeria. The deleterious effects of diabetes have been linked to poor glycemic control. According to the International Diabetes Federation, poor glycemic control is reflected in glycosylated hemoglobin (HbA1c) levels greater than 7.0%, which are associated with substantial morbidity and mortality. Studies have shown a dramatic rise in diabetic complications in Nigeria, particularly in Owerri. However, evidence is lacking on specific risk factors associated with poor glycemic control among DM patients in Owerri. With health insurance assuming a significant position in healthcare service delivery in Nigeria, addressing this …


Educators’ Perception Of Their Psychosocial Support Of Elementary Students In Gabon, Africa, Michel Ikamba Jan 2022

Educators’ Perception Of Their Psychosocial Support Of Elementary Students In Gabon, Africa, Michel Ikamba

Walden Dissertations and Doctoral Studies

Although educators internationally have often provided care to vulnerable students who struggle to meet the needs of nutrition, health, protection, and access to essential social services, no formal social systems exist in Gabon to aid educators who work with these students. In the absence of relevant local research and drawing on Dewey’s theory of progressive education as a conceptual model, this basic qualitative study asked about educators’ perceptions in limited resource elementary schools in Gabon of the social needs and strategies employed with students who demonstrated signs of disengagement and alienation. Qualitative data collection included semi-structured recorded interviews with 12 …


Community Development Practitioner Methods To Support People With Disabilities, Allison E. Lourash Jan 2022

Community Development Practitioner Methods To Support People With Disabilities, Allison E. Lourash

Walden Dissertations and Doctoral Studies

There are numerous programs in the United States (US) that provide services and supports for people with disabilities with significant monetary costs and poor outcomes. Current research lacked information regarding how use of strengths-based approaches by community development practitioners supports people with disabilities and builds social capital. The purpose of this qualitative single case study was to explore community development practitioners’ use of strengths-based approaches to support people with disabilities in their communities. The conceptual framework of social capital was used for the study. The research question involved how community development practitioners identify and provide methods to support people with …


Adverse Childhood Events And Protective Health Behaviors Among Adults With Diabetes Or Diabetes With Comorbid Heart Disease, Ciara Michelle Rukse Jan 2022

Adverse Childhood Events And Protective Health Behaviors Among Adults With Diabetes Or Diabetes With Comorbid Heart Disease, Ciara Michelle Rukse

Walden Dissertations and Doctoral Studies

Diabetes is a prevalent and costly chronic condition that can lead to other comorbid conditions such as heart disease. Disease management is essential but can be stressful and complicated, especially for individuals who have developed maladaptive behaviors in response to exposure to adverse childhood events (ACEs), which are chronic stressors that impact physiological and psychological development. There is limited research on the potential relationship between childhood adversity and engagement in protective health behaviors among U.S. populations with diabetes or diabetes with comorbid heart disease. The ACEs pyramid was the theoretical framework of this quantitative cross-sectional study concerning morbidity and early …


An Exploration On Apts In Biocybersecurity And Cyberbiosecurity, Xavier-Lewis Palmer, Lucas Potter, Saltuk Karahan Jan 2022

An Exploration On Apts In Biocybersecurity And Cyberbiosecurity, Xavier-Lewis Palmer, Lucas Potter, Saltuk Karahan

School of Cybersecurity Faculty Publications

Novel and complex digital threats that are increasingly interwoven with means and products of biology that can affect society. Much work in Biocybersecurity/Cyberbiosecurity (BCS/CBS) discuss vulnerabilities, but few deeply address malicious actor varieties as attacks at this intersection are new. The path to those attacks remains mostly theoretical, presenting considerable difficulty to accomplish in practical scenarios. In terms of advanced persistent threats (APTs) this of course needs to change as biomanufacturing facilities are at risk, considering Covid-19 and other potential pandemics. Further attacks are not out of reach and thus we must start to imagine how BCS APTs may appear. …


Human Capital Management Strategies To Sustain Profitability Of Private Sector Companies In Jamaica, Peta Gay Nadia Waugh Jan 2022

Human Capital Management Strategies To Sustain Profitability Of Private Sector Companies In Jamaica, Peta Gay Nadia Waugh

Walden Dissertations and Doctoral Studies

Eighty-two percent of Jamaican workers are employed by micro, small, and medium-sized enterprises, but only 5.1% of private sector entrepreneurial endeavors remain open after 42 months of operations. This low survival rate can inhibit the ability of Jamaican business owners to support their families and provide goods and services to benefit local communities. Grounded in human capital theory, general systems theory, and social change theory, the purpose of this qualitative descriptive multiple case study was to explore strategies CHROs used to sustain the profitability of their private sector companies. Participants comprised three private-sector CHROs officers and three human resource officers …


Legal Recognition Of Animal Sentience: The Case For Cautious Optimism, Jane Kotzmann Jan 2022

Legal Recognition Of Animal Sentience: The Case For Cautious Optimism, Jane Kotzmann

Animal Sentience

Rowan et al.’s target article provides a valuable indication of the work that was required to reach the point where animals are recognised as sentient in various laws. To ensure this work was not in vain, the language of sentience needs to be used as a moral currency to demand further cultural change involving greater human respect for animals.


The Relationship Between Community College Instructors’ Perception Of Andragogical Orientation And Instructional Style., Renea P. Coley Jan 2022

The Relationship Between Community College Instructors’ Perception Of Andragogical Orientation And Instructional Style., Renea P. Coley

Walden Dissertations and Doctoral Studies

Community colleges in Northern and Southeastern Virginia have struggled with enrollment and retention of adult learners. Addressing adult learners’ needs is an important focus for instructors, yet few studies have addressed how instructors can use andragogy, the art and science of adult learning, to influence their instructional practices to support adult learners. Based on self-determination theory, this quantitative, cross-sectional study examined the extent that 75 community college instructors’ perceived andragogical orientation predicted an autonomy-supportive instructional style controlling for instructor years of teaching, highest degree earned, and gender. Instructors from 10 community colleges in Northern and Southeastern Virginia teaching in the …


Improving Medical-Surgical Nursing Knowledge Of Congestive Heart Failure, Sylvia Rene Cunningham Jan 2022

Improving Medical-Surgical Nursing Knowledge Of Congestive Heart Failure, Sylvia Rene Cunningham

Walden Dissertations and Doctoral Studies

The purpose of this Doctor of Nursing practice project was to address the nursing gap in knowledge about congestive heart failure (CHF) management. Lack of staff knowledge on this topic inhibits their ability to educate patients. Poor patient understanding can lead to frequent readmissions and poor patient outcomes. The project aim was to determine if educating medical-surgical nurses about CHF management increased their knowledge of topic. The ADDIE model was used to design staff education. Lewin’s change theory guided the project. Nine registered nurses attended a power point presentation. A pre-education questionnaire was distributed, and participants created unique identifiers. The …


A Correlational Investigation Of Father Emotional Presence And Gender Role Identity In African American Women, Malika Dandridge Jan 2022

A Correlational Investigation Of Father Emotional Presence And Gender Role Identity In African American Women, Malika Dandridge

Walden Dissertations and Doctoral Studies

The psychological well-being and gender role development of a woman is greatly affected by the emotional presence of her father growing up. Until recently, most of the research on father-daughter relationships has been done on Caucasian working-class families, and very little has been done on father-daughter relationships in the African American community. The purpose of this study was to examine the role of a father’s emotional presence (dependable, involved, engaged) and uncover whether this type of presence was correlated with a woman’s gender role identity among African American women aged 18 years of age or older. The socioeconomic status (working …


Educational Tool Kit For Mental Health Nurses To Combat Compassion Fatigue, Cleopatra Enakhena Jan 2022

Educational Tool Kit For Mental Health Nurses To Combat Compassion Fatigue, Cleopatra Enakhena

Walden Dissertations and Doctoral Studies

Health care professionals, such as mental health nurses, use the two essential tenets of compassion and empathy when caring for their patients. But constant exposure to traumatized patients under a nurse’s care can lead to burnout and compassion fatigue (CF), which affects the nurse’s provision of adequate patient care. Mental health nurses’ lack of education and awareness on CF has led to diminished provision of safe, effective, and quality care to their patients. Therefore, the purpose of this scholarly doctoral of nursing project was to develop an educational tool kit that might help mental health nurses combat CF within their …


Barriers To Completing Bachelor’S Degrees For Nontraditional Nebraska Students, Melba Dinorah Fix-Padilla Jan 2022

Barriers To Completing Bachelor’S Degrees For Nontraditional Nebraska Students, Melba Dinorah Fix-Padilla

Walden Dissertations and Doctoral Studies

AbstractNontraditional students in Nebraska colleges have lower graduation rates than traditional students. Approximately 40% of nontraditional students at a private college withdraw before completing a degree. The purpose of this qualitative study was to discover barriers preventing nontraditional students from completing a degree. The conceptual frameworks were Tinto’s student integration model and Bean’s student attrition model, which involve financial, social, and academic completion resources. Research questions involve financial, social, and academic challenges preventing nontraditional students from completing a degree. The sample consisted of eight nontraditional undergraduate students between the ages of 25 to 65, an undergraduate administrator, and a focus …


Risk Factors Of Infant Mortality Among Sub-Saharan Immigrants In The United States, Roland Lankah Jan 2022

Risk Factors Of Infant Mortality Among Sub-Saharan Immigrants In The United States, Roland Lankah

Walden Dissertations and Doctoral Studies

While prepregnancy body mass index (BMI), gestational weight gain (GWG), and birthplace have been suggested to play a key role in predicting infant mortality outcomes, they have not been thoroughly investigated across all races/ethnicities. The purpose of this study was to examine the associations between prepregnancy BMI, GWG, birthplace as independent variables, and infant mortality as the outcome variable within the United States Sub-Saharan African Immigrants (SSAI). A quantitative cross-sectional study design grounded in the biopsychosocial model was used. Data were extracted from the 2017-2018 natality-linked birth/infant death file from the Centers for Disease Control and Prevention Wonder Database. It …