Digital Commons Network^™

Butting Heads With Respiratory Disease: Post-Epizootic Demography And Movement-Driven Spillover Risk In A Badland’S Bighorn Sheep (Ovis Canadensis) Meta-Population, Sean P. Ryder

Electronic Theses and Dissertations

Respiratory disease caused by Mycoplasma ovipneumoniae is among the most significant threats to bighorn sheep (Ovis canadensis) conservation in North America. In July 2021, contact between bighorn sheep rams and domestic sheep north of Badlands National Park (BADL), South Dakota, USA introduced M. ovipneumoniae into the Badlands bighorn sheep meta-population, triggering an epizootic that reduced the population by approximately 80%. I evaluated the post-outbreak status of this population through two complementary studies conducted from 2023 to 2025. In Chapter 1, I quantified disease prevalence, adult survival, lamb recruitment, and population growth rate (λ) using serial quantitative polymerase chain reaction (qPCR) …

Chemical Load: An Unseen Herbicide Filter In Restored Prairies?, Rylie Franklin

Electronic Theses and Dissertations

Community Assembly Theory is a framework used to describe the process by which species from a regional species pool disperse and encounter various abiotic and biotic conditions that act as filters, limiting which species will populate a specific local community. Prairie restoration success can be improved by understanding abiotic and biotic filters. As agricultural practices have adopted integrated weed management plans, that include the use of both chemical and non-chemical techniques, another filter needs to be considered during restoration: the chemical load of soils, i.e., herbicide residue from recent on-site applications and herbicide drift from adjacent areas. To examine the …

Towards Energy Access For All: Developing The Lived Energy Experience Index (Leei), Kentina Annie Ishimwe

Electronic Theses and Dissertations

Energy is the fuel that powers the engine of civilization. Energy access metrics ensure that nations continuously work towards providing access for all. However, the prevalent binary indicator fails to consider that energy needs to be usable, accessible, affordable, and reliable. As a result, numerous tiered and multidimensional metrics, such as the Multi-Tier Framework, came about to bridge the gap but proved to be complex and complicated to implement. This study presents the existing literature review, assesses the limitations of current energy access measurement frameworks, and compares household energy needs with reported access statistics. Based on the findings, the Lived …

Evaluating Supplementation Strategies Using Precision Livestock Technologies And Energy Based Models In Developing Beef Heifers Grazing Dormant Rangeland, Kali-Jo Bentz

Electronic Theses and Dissertations

Replacement beef heifer development in extensive grazing systems is challenged by variation in forage quality, supplement intake, and animal behavior, all of which influence the ability to achieve targeted growth prior to breeding. Precision livestock technologies (PLT) enable continuous monitoring of individual animal performance, while energy-based nutritional models support individualized supplementation. However, their application under extensive grazing conditions remains poorly understood. Therefore, the objectives of this thesis were to (1) evaluate heifer utilization of multiple precision livestock technologies and their relationship with animal performance and (2) evaluate the accuracy of an individualized energy-based supplementation model by comparing predicted supplement allotments …

Production Of Fungal Biomass And Crude Chitin From Cheese Whey: Effects Of Whey Type And Lactose Hydrolysis On Aspergillus Niger And Trichoderma Reesei, Anye Catharine Nora Drum

Electronic Theses and Dissertations

Chitin is a biodegradable and biocompatible biopolymer with broad applications in the food, biomedical, pharmaceutical, and packaging industries. Conventional chitin production from crustacean shells is associated with seasonal availability, intensive chemical processing, and environmental concerns, creating interest in more sustainable alternatives. Filamentous fungi represent a promising source of chitin because of their rapid growth and ability to utilize low cost agro-industrial residues. This study evaluated the feasibility of producing fungal biomass and crude chitin from cheese whey through submerged fermentation while investigating the effects of whey type and enzymatic lactose hydrolysis on fungal growth, substrate utilization, and wastewater remediation. Aspergillus …

Semantic Discovery Of Genomic Datasets With Ai, Lawrence Allibah

Electronic Theses and Dissertations

Traditional keyword-based search in genomic databases often fails to capture the latent semantic context of biological studies, leading to a ``Lexical Gap" in research discovery. This thesis presents a high-performance dual-engine discovery system built upon 10,000 studies. By utilizing 1,536-dimensional vector embeddings, with large language models (LLMs) we implement a search engine coupled with a novel Hybrid Boosting layer that integrates semantic intent with factual metadata. Furthermore, we apply a high-dimensional K-Means clustering algorithm for unsupervised topic discovery. Empirical benchmarking demonstrates that the Hybrid Boosting engine achieves a 38.1% gain in precision and a 41.2% increase in Mean Reciprocal Rank …

Peculiarities Of Phosphatidylserine Externalization By Nano- And Microsecond Electric Pulses, Mantas Silkunas, Alayna Enos, Iurii Semenov, Giedre Silkuniene, Eleni Zivla, Olga N. Pakhomova, Andrei G. Pakhomov

Bioelectrics Publications

Phosphatidylserine (PS) externalization is a hallmark of apoptosis but can also be triggered within seconds by pulsed electric fields (PEFs). Whether PS reaches the outer leaflet by lateral migration through electropores or indirectly through Ca²⁺-dependent signaling and scramblase activation remains debated. We used total internal reflection fluorescence (TIRF) microscopy with Annexin V-Alexa Fluor 568 and/or bovine lactadherin-FITC to resolve PS externalization in HEK293 cells placed on an indium tin oxide (ITO) transparent electrode. PEF exposures produced discrete PS-positive puncta ("freckles") within ~ 10 s after a 20-µs pulse (1.2-2.5 kV/cm) or with a ~ 1-min delay after a …

The Impacts Of Wing-Flashing By Northern Mockingbirds On Foraging, Parental Care, And Reproductive Success, Anna Reece Starman

Undergraduate Research Awards

Foraging efficiency may be enhanced by flashing patches of white wing and tail feathers and has been documented in several avian species. Northern Mockingbirds (Mimus polyglottos, NOMO) exhibit this “wing-flashing” (WF) behavior while foraging, during displays, and in response to predators. In NOMOs, WF has been hypothesized to increase foraging success, but previous findings are inconclusive. To further investigate the biological role(s) of WF behavior in NOMOs, the ventral surface of white primary feathers of male NOMOs were artificially darkened and the foraging and provisioning rates of undarkened (control) males and their mates were compared. While foraging, undarkened males performed …

Granulomatous Cellular Signatures In Nontuberculous And Tuberculous Mycobacterial Infections, Brianna M. Doratt, Ethan G. Napier, Mahdi Eskandarian Boroujeni, Sarah Douglas, Michael H. Davies, Luiz Bermudez, Eliot Spindel, Erin F. Mccaffrey, Ilhem Messaoudi

Microbiology, Immunology, and Molecular Genetics Faculty Publications

Mycobacterium tuberculosis (Mtb) and nontuberculous mycobacteria (NTM) are acid-fast bacilli that trigger granuloma formation, a hallmark immune response aimed at containing infection. While the biology of Mtb granulomas has been widely investigated, far less is known about granulomas caused by NTM infection, despite the increasing prevalence and clinical challenge of NTM cases worldwide. Because granulomas influence infection control, pathology, and treatment response, understanding their cellular organization and signaling is critical to improving therapeutic strategies. Therefore, we characterized granulomas formed following infection of rhesus macaques with Mycobacterium avium subsp. hominissuis (MAH) and compared them to granulomas from cynomolgus macaques infected with …

Cocaine Upregulates Microglial Lipid Droplet Formation Through Increasing Lipid Synthesis Activity In Vitro And In Vivo, Yan Cheng, Brooke Russell, Liam Liyang Guo, Aryan Patel, Yan Y. Sanders, Ming-Lei Guo

Department of Biomedical and Translational Sciences Faculty Publications

A novel subtype of microglia, lipid droplet accumulation microglia (LDAMs), has been identified in the aged brain, which is characterized by sustained inflammation and senescent-like phenotypes. LDAMs are deeply involved in promoting brain aging as well as the pathogenesis of multiple neurodegenerative diseases. Cocaine can alter brain lipidomic profiles, induce microglial activation, and accelerate brain aging. This suggests that cocaine might affect microglial lipid metabolism, which ultimately aggravates aging-related neurological disorders in people with addictions. In this study, we explored the effects of cocaine on microglial lipid metabolism. Our results showed that chronic cocaine administration altered brain lipid profiles and …

False-Positive Detections In Avian Auditory Surveys: Effects Of Song Number And Directionality In A Calibration-Based Immersive Sound Environment, Katia Elena Chavez

Undergraduate Theses, Professional Papers, and Capstone Artifacts

Detection-based surveys are widely conducted to monitor wildlife populations and provide data for estimating density and abundance. Avian count surveys are especially common because birds respond quickly to habitat degradation and restoration, making them effective indicator species. However, these detection-based surveys rely heavily on human observers and are prone to errors. If left unaddressed, these errors can bias estimates of species occurrence, and abundance, leading to misleading ecological inferences and management decisions. False-positive errors have received limited attention, in part because they are difficult to identify without independent confirmation of true species. To investigate false-positive rates in a controlled setting, …

From Couriers To City Dwellers: The Changing Human-Pigeon Relationship, Mallory C. Peterson

Undergraduate Theses, Professional Papers, and Capstone Artifacts

Their coos echo off the walls of skyscrapers and their wings beat faster than the cadence of footsteps. Whether dodging cars or pecking at food scraps, pigeons are a constant character of urban environments. Their unique history has allowed them to raise their young under bridges and on windowsills. Pigeons and humans are inextricably intertwined, to the joy and dismay of many. Once celebrated as couriers, pigeons carried messages of war, love, and survival across vast distances, shaping human connection and history. Today, they are more often dismissed as pests, their presence flattened into the city noise.

This narrative piece …

Long-Term Banding And Encounter Patterns Of Cinnamon Teal Banded In Utah (1960-2025), Gracie A. Henrie

Undergraduate Theses, Professional Papers, and Capstone Artifacts

Utah is a valuable breeding and nesting ground for a number of waterfowl species, largely because of the Great Salt Lake, which supports over 400,000 acres of wetland habitat (Ducks Unlimited, n.d.). The Utah Division of Wildlife Resources manages 24 wildlife management areas (WMAs) with the purpose of creating high quality waterfowl habitat in these wetlands that can be enjoyed by hunters, recreators, and birds alike (Wildlife/Waterfowl Management Areas (WMAs), 2025). Effective management is supported with an understanding of the movement and demographic patterns of the waterfowl species the WMAs are designed to support. Bird banding is one tool managers …

Chid Support From Conception?: An Analysis Of And Argument For Enacting A Model Code For The Provision Of Child Support Prior To The Birth Of The Child, Richard Waugaman

Scholarly Works

No abstract provided.

Sex Differences In Allergic Asthma Responses Of Mice Prenatally Exposed To Wood Smoke, Adelynne Walley

Undergraduate Theses, Professional Papers, and Capstone Artifacts

No abstract provided.

Array Signal Processing And Machine Learning In 5g/6g Networks, Roopesh Kumar Polaganga

Electrical Engineering Dissertations - Archive

This dissertation investigates advanced methodologies in Array Signal Processing (ASP) and Machine Learning (ML) to enhance the performance, efficiency, and intelligence of next-generation wireless networks, with a primary focus on 5G and emerging 6G systems. As wireless networks face rapid traffic growth, increasingly heterogeneous service requirements, and more complex propagation environments, conventional design and optimization approaches become insufficient to meet evolving demands in reliability, capacity, spectral efficiency, and energy efficiency. On the network intelligence side, this work develops data-driven frameworks for causal discovery, scheduler enhancement, session-duration prediction, and Radio Resource Control (RRC) state optimization using real-world telecommunication network data. On …

Scope Of Microbial Transglutaminase For Site-Specific And Oriented Immobilization Of Native Antibodies From Various Host Species, Emily Beitello, Kwame Osei, Faith E. Breausche, Jon A. Friesen, Jeremy D. Driskell

Faculty Publications – Chemistry

Modification of antibodies to chemically couple labels or immobilization reagents is essential for developing biosensors. Typically, conjugation occurs through chemical methods that leverage reactive amines and thiols on native antibodies; however, this nonspecific approach can interfere with antibody function. Microbial transglutaminase (mTG) is an enzyme that has been used for site-specific conjugation of chemical modifiers to the F_c region of native antibodies, but thus far mTG-mediated conjugation has been limited to production of antibody-drug conjugates with human IgGs. Here, we assessed the scope and versatility of mTG to target IgGs, with the goal of site-specific conjugation to facilitate oriented …

Put Me In, Coach: Enhancing Foundational Lawyering Skills Across The Curriculum With Neurodivergent Law Students In Mind, Erica M. Lux

Mitchell Hamline Law Review

As more adults discover that they are neurodivergent, the law student population is likely to be no different, and legal education must adapt to support the skill development needs of neurodivergent students as they prepare to enter the profession. Neurodivergence is a non-medical term that refers to a variety of conditions resulting from changes to a person’s brain structure and function. More commonly, academic discussions around neurodivergence focus on autism spectrum disorder (ASD) and attention deficit hyperactivity disorder (ADHD)—both of which have not been properly diagnosed over the past several decades. However, neurodivergence also incorporates anxiety disorders, obsessive-compulsive disorder (OCD), …

"Just Friends:" The Linguistics Of Queerness In Lady Audley's Secret And Carmilla, Kelley A. Peters

English

Many queer studies scholars have debated the legitimacy of queer coding within Victorian literature, such as Marc Milton Ducusin, who wrote Queer Doubles: The Victorian Sensation Novel and English Sexology, and Sharon Marcus, the author of Between Women: Friendship, Desire, and Marriage in Victorian England. These authors analyze real-life and fictional behaviors of those within Victorian England to argue that queerness is present in certain Victorian works. However, these arguments do not adequately address the linguistic significance of the queer coding present in these works, and they specifically ignore the label of “friend” and its many meanings in Victorian …

The Relationship Between Culturally Responsive Teaching (Crt) Training, Teachers’ Children’S Book Choices, And Perceptions Of Censorship In Kuwait, Norma Gina Lombardi Sciarra

All Electronic Theses and Dissertations

Teachers who are culturally responsive use classroom materials that reflect their students' ethnicities, traditions, and values. Western teachers have access to diverse books and classroom tools. They have the agency to choose materials that support the curriculum. However, when Western educators work abroad, they must adapt their teaching methods and tools to local norms. Working abroad may require censoring or omitting information and content they believe in and support. As a result, teachers may feel dissonance or conflict when censoring. Censoring may impact their ability to teach comprehensively. Little research examines the relationship between culturally responsive teaching (CRT), perceptions of …

Cultivating Holistic And Mindful Rest Practices: A Workbook, Cecelia V. Murray

Mindfulness Theses

In a cultural moment that conflates productivity with self-worth, rest is often undervalued or seen as indulgent. This thesis explores mindfulness as a means of reframing rest as an essential human right and a cornerstone of holistic wellness. Drawing on Bill Hettler’s Six Dimensions of Wellness (i.e. physical, intellectual, emotional, social, spiritual, and occupational wellness), this project situates mindful rest as a multidimensional practice that supports balance across body, mind, and spirit. This work also highlights the social, structural, and psychological barriers that affect individuals’ access to rest. It argues that while mindfulness alone cannot resolve systemic inequities, it can …

Mindfulness And Psychedelics: Rethinking The Fifth Precept, Ernesto Londono

Mindfulness Studies Theses

The fields of psychedelics and mindfulness have a long history of cross-pollination in the United States that dates to the counterculture movement in the 1960s. As the use of these mind-altering compounds in therapeutic and spiritual contexts has become less stigmatized and more popular in recent years, psychedelic retreats and therapies are once again drawing people who also value contemplative practices. This paper explores the historic and contemporary tension people with overlapping interests in mindfulness and psychedelics have faced as they interpreted the Fifth Precept, the Buddhist guideline that advises people to abstain from intoxicants. Taking stock of the history …

What Truly Drives Graduate Earnings?, Aiden Akbarov

High Impact Practices Student Showcase Spring 2026

The goal of my project, Predicting the Paycheck: What Factors Truly Influence Graduate Earnings?, was to see if we could actually predict a college graduate's starting salary using data instead of just guessing. I used a dataset of 172 majors from the American Community Survey to look at how a student's field of study, the gender balance of their major, and the current job market all impact their first paycheck. I wanted to create a tool that helps students understand the financial reality of their degree before they even graduate.

To get my results, I used a Multiple Linear Regression …

A Review Of Mobility And Gait Changes In Patients With Prostate Cancer: Disease Stage, Symptom, And Treatment-Related Influences, Lauren Hathorn, Abigail Schmitt Dr

2026 Honors Symposium

Background: This review examines the impact of prostate cancer symptoms, progression, and treatments on patients’ gait and mobility. Prostate cancer is the leading cancer diagnosis for men in the United States, with an increase in incidents in the last decade. Prostate cancer, its progression, and its various symptoms and treatments have both physical and functional consequences that often cause changes in patients’ mobility and gait. Some studies have found gait to be a predictor of functional decline and mortality. Given that functional decline and mortality are also consequences of cancer progression and cancer treatments, gait analysis could offer a non-invasive …

Court-Mandated Parenting Intervention: A Parenting Program To Reduce Conflict And Increase Positive Coping Skills For High-Conflict Parents In Family Court, Joshua T. Metcalf

Psychology Doctoral Specialization Projects

The number of children in the United States whose parents have either separated or divorced has continued to increase over time. While some parents are able to effectively co-parent their children after separation or divorce, others may be unwilling or unable to effectively do so. Parents who ineffectively co-parent their children, often referred to as high conflict co-parents, can often over utilize family court resources to solve disputes and to make co-parenting decisions. In the literature review presented, current co-parenting resources often utilized by family courts are explored and research regarding current co-parenting interventions is discussed. Additionally, key components of …

Does Voluntary Manslaughter Exist In South Dakota?, Gregory Brazeal

Faculty Publications

The American legal tradition generally distinguishes between cold-blooded, premeditated intentional killing and hot-blooded, spontaneous intentional killing. The former has traditionally been categorized as murder and the latter as the lesser crime of “voluntary manslaughter.” South Dakota’s homicide statutes, interpreted based on their plain meaning, depart from this deeply rooted tradition. The closest equivalent to the crime of voluntary manslaughter appears in South Dakota’s first-degree manslaughter statute, which includes a prohibition on homicide “[w]ithout any design to effect death . . . and in a heat of passion, but in a cruel and unusual manner.” The phrase “heat of passion” suggests …

Optimization Of Fucoxanthinol Production Using Michaelis-Menten Kinetics, Jennifer Cagnolatti, Naohiro Kato

Distinguished Undergraduate Researcher Program

Fucoxanthin, a carotenoid pigment found in algae, is known for its antioxidant and anti-inflammatory properties. Its active form, fucoxanthinol, has shown promise as a potential medicine for asthma. This study aims to optimize the enzymatic conversion of fucoxanthin to fucoxanthinol to enhance its bioavailability as a therapeutic compound, through modeling and validating of Michaelis-Menten kinetic parameters. The kinetic parameters include the forward and reverse rate constants (kf, kr), the catalytic rate constant (kcat), and the Michaelis constant (KM). To determine kinetic parameters, pure fucoxanthin was extracted from dried algae using solid-phase extraction. The enzymatic reaction was conducted using lipase and …

Methylenetetrahydrofolate Reductase (Mthfr) Polymorphisms And Neural Tube Defects In African Populations: A Global Meta-Analysis And Population Genetic Characterization In Uganda, Nana Ekua Entsiwa Adenu-Mensah

Yale Medicine Thesis Digital Library

Background: Neural tube defects (NTDs) affect 1.9 per 1,000 births globally, with the highest burden occurring in African populations that remain underrepresented in genetic epidemiology. The methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C polymorphisms reduce enzyme activity and have been associated with increased NTD risk in several populations, though their relevance across African regions remains unclear.

Methods: We conducted: (1) an updated systematic review and meta-analysis of MTHFR C677T and A1298C polymorphisms and NTD risk (66 studies, ~22,000 participants); (2) population-level genotype characterization of 978 Ugandan children using whole-genome sequencing; and (3), a comparative analysis of MTHFR C677T allele frequencies across …

Lapses In Care Among Patients With Proliferative Diabetic Retinopathy: A Mixed-Methods Study, Serina Sera Applebaum

Yale Medicine Thesis Digital Library

Proliferative diabetic retinopathy (PDR) affects approximately 7% of individuals with diabetes and requires consistent follow-up to prevent irreversible vision loss. Despite this, lapses in PDR care are common, but poorly characterized. We conducted a two-phase mixed-methods evaluation, including a quantitative retrospective national cohort study of individuals with PDR, followed by a qualitative study investigating participant perspectives on their own lapses in PDR care. In the quantitative component, we used data from 13 academic health systems in the Sight Outcomes Research Collaborative (SOURCE) Repository between 2008 and 2023 to identify adults aged ≥18 with PDR and ≥6 months of ophthalmic follow-up. …

Social Drivers Of Healthcare Access In Pediatric Autoimmune Disease: A U.S. Analysis (2022–2023), Kevin Okifo

Yale Medicine Thesis Digital Library

Background: Prior studies in adults have demonstrated that social drivers of health contribute to disparities in disease burden, management, and healthcare access among individuals with autoimmune disease (AD). There is emerging pediatric evidence suggesting similar patterns, but national-level data describing how social and structural factors shape healthcare access for children with AD remain limited. The aim of this study is to identify the sociodemographic and structural factors associated with healthcare access among children and adolescents with AD in the United States. Understanding these factors can support meaningful advances that will optimize patient-centered care and wraparound services for pediatric AD.Study Design: …