Digital Commons Network^™

Board Of Regents Meeting Materials, December 8, 2022, Eastern Michigan University

Board of Regents Meeting Materials

No abstract provided.

Perspectives And Experiences With Covid-19 Vaccines In People With Ms, John R Ciotti, Dana C Perantie, Brandon P Moss, Kathryn C Fitzgerald, Jeffrey A Cohen, Ellen M Mowry, Robert T Naismith, Salim Chahin

Open Access Publications

Background: People with MS may have unique perspectives on COVID-19 vaccines due to their condition and/or medications.

Objective: Assess perspectives and experiences with COVID-19 vaccination, and quantify variables impacting COVID-19 vaccine willingness in people with MS.

Methods: A survey captured demographics, MS characteristics, and COVID-19 infection and exposures data; opinions on COVID-19 vaccine safety, side effects, and efficacy; and experiences following vaccination. Chi-square tests and a logistic regression model were used to denote between-group differences and variables predicting vaccine willingness, respectively.

Results: Most (87.8%) of the 237 participants were willing to receive the vaccine. Fifteen percent held or delayed a …

Essential Functions Of Mll1 And Mll2 In Retinal Development And Cone Cell Maintenance, Chi Sun, Xiaodong Zhang, Philip A Ruzycki, Shiming Chen

Open Access Publications

MLL1 (KMT2A) and MLL2 (KMT2B) are homologous members of the mixed-lineage leukemia (MLL) family of histone methyltransferases involved in epigenomic transcriptional regulation. Their sequence variants have been associated with neurological and psychological disorders, but little is known about their roles and mechanism of action in CNS development. Using mouse retina as a model, we previously reported MLL1's role in retinal neurogenesis and horizontal cell maintenance. Here we determine roles of MLL2 and MLL1/MLL2 together in retinal development using conditional knockout (CKO) mice. Deleting

It's Getting Complicated-A Fresh Look At P53-Mdm2-Arf Triangle In Tumorigenesis And Cancer Therapy, Che-Pei Kung, Jason D Weber

Open Access Publications

Anti-tumorigenic mechanisms mediated by the tumor suppressor p53, upon oncogenic stresses, are our bodies' greatest weapons to battle against cancer onset and development. Consequently, factors that possess significant p53-regulating activities have been subjects of serious interest from the cancer research community. Among them, MDM2 and ARF are considered the most influential p53 regulators due to their abilities to inhibit and activate p53 functions, respectively. MDM2 inhibits p53 by promoting ubiquitination and proteasome-mediated degradation of p53, while ARF activates p53 by physically interacting with MDM2 to block its access to p53. This conventional understanding of p53-MDM2-ARF functional triangle have guided the …

Wormbase In 2022-Data, Processes, And Tools For Analyzing Caenorhabditis Elegans, Paul Davis, Tim Schedl, Et Al

Open Access Publications

WormBase (www.wormbase.org) is the central repository for the genetics and genomics of the nematode Caenorhabditis elegans. We provide the research community with data and tools to facilitate the use of C. elegans and related nematodes as model organisms for studying human health, development, and many aspects of fundamental biology. Throughout our 22-year history, we have continued to evolve to reflect progress and innovation in the science and technologies involved in the study of C. elegans. We strive to incorporate new data types and richer data sets, and to provide integrated displays and services that avail the knowledge generated by the …

Mcnair Scholars Research Journal 2022, Haleigh R. Hicks, Naponi Jada, Justine Phan, Promise Robinson, Rocio E. Vegamartinez, Paula Currie, David Antonio Diaz, Alexia J. Hartzell, Ariana Hernandez, Kayla Meyers, David O.T. Ogidan, Jose David Perez Vela, Riley Wiland

McNair Scholars Research Journal-Archive

No abstract provided.

Expanding Mouse-Adapted Yamagata-Like Influenza B Viruses In Eggs Enhances In Vivo Lethality In Balb/C Mice, Matthew J. Pekarek, Erika M. Petro-Turnquist, Adam Rubrum, Richard J. Webby, Eric A. Weaver

Nebraska Center for Virology: Faculty Publications

Despite the yearly global impact of influenza B viruses (IBVs), limited host range has been a hurdle to developing a readily accessible small animal disease model for vaccine studies. Mouseadapting IBV can produce highly pathogenic viruses through serial lung passaging in mice. Previous studies have highlighted amino acid changes throughout the viral genome correlating with increased pathogenicity, but no consensus mutations have been determined. We aimed to show that growth system can play a role in mouse-adapted IBV lethality. Two Yamagata-lineage IBVs were serially passaged 10 times in mouse lungs before expansion in embryonated eggs or Madin–Darby canine kidney cells …

Dissecting The Cellular Landscape And Transcriptome Network In Viral Myocarditis By Single-Cell Rna Sequencing, Ninaad Lasrado, Nicholas Borcherding, Rajkumar Arumugam, Timothy K. Starr, Jay Reddy

School of Veterinary and Biomedical Sciences: Faculty Publications

Coxsackievirus B3 (CVB3)-induced myocarditis is commonly employed to study viral pathogenesis in mice.Chronically affected micemaydevelop dilated cardiomyopathy, which may involve the mediation of immune and nonimmune cells. To dissect this complexity, we performed single-cell RNA sequencing on heart cells from healthy and myocarditic mice, leading us to note significant proportions of myeloid cells, T cells, and fibroblasts. Although the transcriptomes of myeloid cells were mainly of M2 phenotype, the Th17 cells, CTLs, and Treg cells had signatures critical for cytotoxic functions. Fibroblasts were heterogeneous expressing genes important in fibrosis and regulation of inflammation and immune responses. The intercellular communication networks …

Water Current, Volume 54, No. 1, Winter 2022

Water Current Newsletter

No abstract provided.

Post & Lintel, Fall 2022, Preservation Eastern

Post & Lintel

No abstract provided.

Paths To Downstream Innovation, Janet Freilich

Faculty Scholarship

No abstract provided.

Four Privacy Stories And Two Hard Cases, Jessica Silbey

Constitutional Commentary, Vol. 37 and later (2023–present)

No abstract provided.

How Epistolary Novelists’ Literalizations Of Moral Sense Philosophy Dramatize The Long-Eighteenth Century’S Gender Battles, Melissa Stacey Bishop-Magallanes

CGU Theses & Dissertations

While some might consider epistolary novels of the long-eighteenth century as the sentimental purview of women readers, this research proposes that many of these epistolary novels serve as powerful markers in the gender wars of this era. While an overall sense of optimism pervaded Britain’s long-eighteenth century, people still grappled with foundational moral questions. These questions came to be addressed in increasingly secular ways by moral philosophy. As these philosophers occupied influential government, law, and publishing positions, their ideas and works greatly influenced the public imagination. The publications of moral philosophers—such as John Locke, the third Earl of Shaftesbury, Joseph …

A Framework For And Design Of A Smart Academic Building Using Sensors, Citizen Participation, And Volunteered Geographic Information, Neelam Raigangar

CGU Theses & Dissertations

Population growth and migration patterns have shown an influx of residents from rural to urban environments. To deal with the problems caused by unprecedented urban influx, cities should plan to use technology in a smart and distinctive way. Tackling at the city scale is hard. But a set of smart buildings that are interconnected by technology will lead to smarter communities which are then interconnected to create a smart city. Smart lobby, building, community, or city is distinguished by its application of integrated software, hardware, and network technologies, along with access to real-time data enabling decision-making, facilitating tracing, tracking and …

Bridging Psychometric And Cognitive Models Of (General) Intelligence: An Investigation Based On Process Overlap Theory, Han Hao

CGU Theses & Dissertations

Human intelligence has been scientifically investigated as a psychological construct for over a century but there has not been a universally accepted definition or theory. One cause of this problem is that traditional theories attempt to explain the robust findings in cognitive ability testing, such as the positive manifold, from two different perspectives: psychometric or cognitive. Both approaches have their own limitations and are sometimes incompatible with each other. Therefore, contemporary theories of intelligence have been developed to provide a more unified perspective by combining both types of approaches, allowing the psychometric structure of cognitive abilities to be represented and …

The Water Is On Fire: Current Circuit Approaches To Fee-Shifting In Citizen-Suits Under The Clean Water Act And The Need For Clearer And More Uniform Standards, Charles Kinley

William & Mary Environmental Law and Policy Review

This Note will start by providing a short explanation of the origins of and congressional goals for the fee-shifting provision in the CWA [Clean Water Act]. It will then offer a brief summary of how Supreme Court precedent has both clarified and confused this issue. Then, it will dive into an examination of how the different circuits and their district courts have interpreted the CWA’s fee-shifting provision and how these interpretations have struggled with past Supreme Court decisions. Finally, this Note will explore the costs and benefits associated with these fee-shifting standards and offer a potential solution to this problem. …

Law On The Half Shell: Applying A Right-To-Farm Framework To Virginia's Aquaculture Industry, Matt Woodward, Andrew Corso

William & Mary Environmental Law and Policy Review

Adapting the state’s existing RTF [Right-to-Farm] regime to include aquaculture has the potential to help Virginia navigate an array of economic and legal challenges. This Article examines the intersection of RTF law and aquaculture and discusses the role that RTF law may play in encouraging Virginia’s expanding aquaculture industry. Part I offers an overview of RTF laws and their operation in Virginia. Part II discusses aquaculture generally and Virginia’s expanding aquaculture industry. Part III documents problems faced by aquaculture producers in Virginia under Virginia’s existing RTF law. Part IV details related challenges facing the industry. Part V concludes by detailing …

Effects Of Heterocycles On Biologically Relevant Molecules, Sajith Manjrake Vijayan

Electronic Theses and Dissertations

It is difficult to overstate the importance of heterocycles in many fields of science (including organic, inorganic, pharmaceutical, medicinal, and material science). Due to their remarkable potential for being involved in a vast array of reactions, heterocyclic molecules make up the majority of pharmaceuticals as well as more than half of all natural products. Moreover, nature widely uses heterocycles, and scientists learned to imitate nature by incorporating them into drug molecules to enhance their biological activity. In this research work emphasize the use of heterocycles in biomedical applications.

The first study presents the design, synthesis, and computational evaluation of four …

Inclusive Music Teacher Preparation In The Presbyterian College Of Education At Akropong-Akuapem, Ghana, Samuel Agbenyo

Electronic Theses and Dissertations

For the past three decades, Inclusive Education (IE) has emerged as a crucial educational agenda all over the world. In this study, IE is the practice of including students with disabilities in the general (music) education classroom, where they are educated together with their typically developing peers. Although IE efforts began in Ghana in 1957, some pitfalls have characterized the implementation process over the years, especially regarding music teacher preparation to implement the policies. Studies have reported a state of frustration among stakeholders, notably the elementary school teachers, who feel inadequately prepared to teach within IE settings. In this case …

Resilience Capacity Of School Meal Programs In Southeastern U.S. School Districts During The Covid-19 Pandemic: Findings From Mississippi, Louisiana, And West Virginia, Kritika Gupta

Electronic Theses and Dissertations

Mississippi (MS), Louisiana (LA), and West Virginia (WV) have some of the nation’s highest rates of poverty and health disparities, reflected in high rates of food insecurity. Many of the school districts in these states have greater than 40% of students qualifying for free meals and, under community eligibility, can provide meals free to all children. School meals play an important role in addressing food insecurity in the U.S. and those were severely affected by the COVID-19 pandemic. The ability of social systems (schools) to continue operations during adverse circumstances (pandemic) to ensure the sustained outcome of interest (food security) …

Hiv-1 Tat And Opioids: Implications For Stress-Related Psychopathology, Salahuddin Mohammed

Electronic Theses and Dissertations

The overarching goal of this dissertation was to assess the interaction of HIV-1 Tat protein with opioids like oxycodone and the hypothalamic-pituitary-adrenal (HPA) axis and develop novel therapeutic strategy to restore HPA dysfunction in adult HIV-1 Tat transgenic mice. In the past 3 decades, combined antiretroviral therapeutics (cART) has increased the life expectancy of HIV infected individuals, with a significant decline in the number of deaths. However, due the inability of cART to sufficiently target latent CNS viral reservoirs (predominantly microglia and astrocytes to a lesser extent), approximately 50% of the HIV+ infected population contends with neurological, neuropsychiatric and neuroendocrine …

Botanicals As Prospective Agents Against Sars-Cov-2 Virus, Vyacheslav Dushenkov, Anna Dushenkov

Publications and Research

The COVID-19 high morbidity and mortality resulted in a worldwide healthcare emergency that triggered accelerated and amplified efforts in the relevant areas of health sciences research and practice. Purpose: To assess the potential role of botanicals as therapeutic agents against the SARS-CoV-2 virus. Methods: This narrative review examined the potential role of botanicals as therapeutic agents against the SARS-CoV-2 virus based on the references limited to the English language and published up to February 2022 and retrieved from common academic search engines using multiple keywords and their combinations. The scientific names of plant species were confirmed using World Flora Online …

Exploratory Studies On The Feasibility Of Developing Microneedles Using Hot Melt Extrusion Coupled With Fused Deposition Modeling 3-D Printing, Nikeeta Palande

Electronic Theses and Dissertations

Transdermal drug delivery enables efficient local and systematic drug delivery while offering advantages such as non-invasiveness, patient compliance, and avoidance of first pass metabolism compared to parenteral administration. Due to strong and the multi-layered structure of the skin creates complex barriers which makes the delivery of therapeutic agents across the skin becomes challenging. Microneedles have been shown to deliver drugs through the transdermal route by penetrating the skin’s protective barrier, stratum corneum (SC) and creating a pathway for drug permeation to the dermal tissue. Traditionally, microneedles were fabricated using various types of materials and process such as casting, injection moulding, …

Design Of An Ophthalmic Nanostructured Lipid Carrier Containing Amphotericin B And Nonadecanoic Acid For The Management Of Fungal Keratitis, Vishal Shah

Electronic Theses and Dissertations

Fungal keratitis is a fungal infection of the cornea. Untreated ocular infections can damage the unique, delicate structures of the eye leading to blindness and visual impairments. It primarily affects the corneal epithelium and stroma, although the endothelium and anterior chamber of the eye may get involved in more severe disease. Amphotericin B (AMB) is a macrocyclic polyene that poorly penetrates ocular tissues. However, AMB is a drug of choice used for the treatment of fungal keratitis caused by Candida. Nonadecanoic acid (NDA) is a 19-carbon fatty acid obtained from plants or bacteria which has shown antifungal activity and acts …

Covid-19 And Headache-Related Disability, Lauren Thaxter

Electronic Theses and Dissertations

Migraine is a common nervous system disorder that is a leading cause of disability worldwide, and approximately half of individuals with migraine report their migraine attacks cause substantial impairment in activities. A bidirectional relationship exists between migraine and psychological symptoms, and comorbid psychological symptoms compound migraine-related disability. Due to COVID-19 pandemic response procedures, many university students experienced institutional closures and corresponding increases in depression, stress, and anxiety, with the most prominent worries being about one's own health and the health of loved ones. The present study aimed to explore the relationship between COVID-19 status (pre-COVID vs. during COVID) and headache-related …

“Darling, Beauty Is Pain”, Porranee Singpliam

Manusya, Journal of Humanities

How has postfeminist media culture traveled transnationally? What contributes to the postfeminist media’s popularity in Thailand? This paper performs a content analysis of YouTube’s reality show, This is Me Vatanika. The show features gender issues and the promotion of gender equality, enhances women’s empowerment, encourages women’s leadership and rhetorically calls upon its viewers to partake in the process of self-invention. I draw upon postfeminist media culture and its sensibilities and argue that this reality show inspires a new modality of femininity endemic in Thai society and that it interpolates neoliberal women in line with the logic of wealth and class, …

Bissu’S Transvestites In The Buginese-Makassar Tradition Through The Transformation Of Faisal Oddang’S Literary Works: An Intertextuality Study, Saharul Hariyono, Nurhadi Bewe

Manusya, Journal of Humanities

Writer Faisal Oddang narrated the existence of the bissu community seemingly reconstructed from an understanding of the historical text to become more colorful. This article questions how the transformation model of bissu community figures is revealed in Oddang’s fictional work. This study utilizes Julia Kristeva’s intertext abstracted through ideologeme as a text arrangement that refers to the space of exterior texts (semiotic practice). The results of the study show: first, how the transformation model of the bissu community character appears in the work of fiction; second, the libido of bissu community in their sacred place; third, the bissu community character …

Identification And Characterization Of Transcription Factors Regulating Methionine Gamma-Lyase Gene Expressionin Durian Durio Zibethinus M. Pulps, Pinnapat Pinsorn

Chulalongkorn University Theses and Dissertations (Chula ETD)

Durian (Durio zibethinus L.) is an economic fruit crop in Southeast Asia. In Thailand, more than 200 durian varieties are found. Among them, two commercial cultivars which are Chanee and Monthong are mainly cultivated. Durian fruit releases a strong sulfuryl odor containing ethanethiol, methanethiol, and hydrogen sulfide during ripening. Methionine γ-lyase (MGL) is an enzyme responsible for α, γ-elimination of L-methionine into methanethiol, ammonia, and α-ketobutyrate. MGL gene is highly expressed in durian pulps during ripening concurring with methanethiol production during ripening. However, the function of durian MGL (DzMGL) has not been characterized. Thus, the enzymatic activity assay towards L-methionine, …

Realizing Diversity, Sustainability, And Stakeholder Capitalism, Peter H. Huang

Emory Business Law Review

Stakeholder capitalism conceives of capitalism with companies maximizing their long-term value, while considering in addition to the interests of their shareholders, also the interests of all their other stakeholders. Examples of such additional stakeholders include customers, employees, communities, creditors, competitors, society at large, and our planet. America today does not have stakeholder capitalism. Instead, America presently has shareholder capitalism, in which publicly held corporations only maximize their stock value to shareholders.

This Essay analyzes proposals for the United States Securities Exchange Commission to require that all reporting companies make periodic mandatory Environmental, Social, and Governance (ESG) disclosures of comparable, standardized, …

Integrating Social Justice Advocacy In Clinical Supervision, Mary Rodgers

Walden Dissertations and Doctoral Studies

A research gap exists on the process for how supervisors effectively address social justice advocacy (SJA) in clinical supervision within the counseling profession. The purpose of this constructivist grounded theory (CGT) study was to increase understanding of the process by which SJA can be integrated into clinical supervision and thus generate a theory for teaching supervisors to effectively integrate SJA into clinical supervision. A constructivist grounded theory approach provided direction on the structure of this study to identify how professors who are social justice advocates and provide clinical supervision to doctoral students in Council for Accreditation of Counseling and Related …