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Articles 155761 - 155790 of 819442

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Radical Trachelectomy For Invasive Cervical Cancer : A Pathway To Fertility For Some, But Not Without Repercussions, Erica Jamro-Comer Jan 2022

Radical Trachelectomy For Invasive Cervical Cancer : A Pathway To Fertility For Some, But Not Without Repercussions, Erica Jamro-Comer

Legacy Theses & Dissertations (2009 - 2024)

BackgroundRadical trachelectomy (RT) is a surgical procedure that offers a substantial benefit to women diagnosed with invasive cervical cancer: fertility preservation. However, as a newer surgical option, there are still many unknowns about the characteristics and outcomes of women who undergo this procedure after a cervical cancer diagnosis. Initial research in this area indicates that some disparities exist in who has the surgery versus the standard radical hysterectomy procedure; however, these are not fully understood and characterized. Furthermore, little is known about how women plan their families and how their high-risk pregnancies are managed in the absence of a standard …

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Educational Materials And Image Induction Increase Treatment Credibility, Zi Ling Fiona Low Jan 2022

Educational Materials And Image Induction Increase Treatment Credibility, Zi Ling Fiona Low

Legacy Theses & Dissertations (2009 - 2024)

Patient-perceived treatment credibility is linked to important outcome measures including symptom reduction, therapeutic alliance, patient satisfaction, and attrition rates. However, few studies have tested strategies to enhance treatment credibility. The present study investigates the effect of brief, written educational materials and the use of an image induction prime on perceptions of credibility for cognitive behavioral therapy and psilocybin-assisted therapy for depression. Participants (N = 493) rated the perceived credibility of depression treatments before and after reading brief educational materials. Half of the participants were asked an image induction question priming the construct of open-mindedness. Results indicate that brief educational materials …

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Institutionalized Normative Heterosexuality : The Case Of Sexual Fluidity, Nicole Lamarre Jan 2022

Institutionalized Normative Heterosexuality : The Case Of Sexual Fluidity, Nicole Lamarre

Legacy Theses & Dissertations (2009 - 2024)

Since Alfred Kinsey’s early exploration of sexual behaviors, identities, and desires, there has been a proliferation of studies on what is generally regarded today as sexual fluidity. Inquiry into sexual histories that are neither wholly heterosexual nor homosexual (or even bisexual) has been incredibly well documented by this time. Generally, theories about sexual fluidity have taken one of two positions. The first camp interprets sexual variance as a sign of changing times and crumbling sexual and gender binaries. The second group of theorists postulate that sexual fluidity is neither new nor a particularly positive or liberating social trend. Instead of …

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Examining The Potential Of Epigenetic Age To Mediate The Relationship Between Adverse Childhood Experiences And Locus Of Control Using The Alspac Cohort, Christopher Reddy Jan 2022

Examining The Potential Of Epigenetic Age To Mediate The Relationship Between Adverse Childhood Experiences And Locus Of Control Using The Alspac Cohort, Christopher Reddy

Legacy Theses & Dissertations (2009 - 2024)

Adverse childhood experiences (ACEs) are negative events and environments (e.g., poverty) that occur during childhood and are known to undermine health and wellbeing. Adverse childhood experiences are related to cognitive outcomes in populations of children. A specific area of cognition associated with ACEs is locus of control (LoC). While the association between ACEs and LoC is clear, what is not well understood is how—that is, through what mechanism—ACEs influence LoC. The purpose of this research was to evaluate epigenetic age as a potential mechanism connecting ACEs with LoC. To address this hypothesis, a mediation model was evaluated using the Accessible …

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X Ray Phase And Coherent Scatter Imaging Measurements, Mahboob Ur Rehman Jan 2022

X Ray Phase And Coherent Scatter Imaging Measurements, Mahboob Ur Rehman

Legacy Theses & Dissertations (2009 - 2024)

In conventional radiography, anatomical information of the patients can be obtained, distinguishing different tissue types, e.g. bone and soft tissue. However, it is difficult to obtain appreciable contrast between two different types of soft tissues. Instead, coherent x-ray scattering can be utilized to obtain images which can differentiate between normal and cancerous cells of breast. An x-ray system using a conventional source and simple slot apertures was tested. Materials with scatter signatures that mimic breast cancer were buried in layers of fat of increasing thickness and imaged. The result showed that the contrast and signal to noise ratio (SNR) remained …

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Inhibition Of Lysine Acetyltransferases Kat 3a/3b And Its Effect On Poliovirus Proliferation, Eduards Norkvests Jan 2022

Inhibition Of Lysine Acetyltransferases Kat 3a/3b And Its Effect On Poliovirus Proliferation, Eduards Norkvests

Legacy Theses & Dissertations (2009 - 2024)

Ribosomes have been traditionally viewed as invariable machinery, but in recent years more and more evidence for their heterogeneity has emerged. Core ribosomal proteins, ribosomal-associated proteins, and post-translational modifications all contribute to the variations found within these crucial subcellular components.In our research, we focused on lysine acetylation – a post translational modification found on many ribosomal proteins. We used a chemical inhibitor of acetyltransferases KAT 3A and KAT 3B to observe the effect that inhibiting acetylation may have in the context of translation. By using poliovirus to shut off conventional cellular translation, we were able to look at a narrow …

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Salivary Gland Stromal Heterogeneity And Epithelial Controls, Nicholas L. Moskwa Jan 2022

Salivary Gland Stromal Heterogeneity And Epithelial Controls, Nicholas L. Moskwa

Legacy Theses & Dissertations (2009 - 2024)

Organogenesis is the process organs go through where cellular communications coordinate all a developing organ needs. What organs need are more cells, in the right place, doing the right job. In the salivary gland, we know that stromal cells are important for organogenesis and that they coordinate the epithelium’s form and functions. However, specific stromal contributions have focused on epithelial quantity and placement. There is less information about how the stroma directs the epithelium towards certain functions. Here we used organoids as a model for understanding what stromal signaling directs epithelial cell fate. We found that stromal cell state is …

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A Mixed Methods Exploration Of Fairness Issues In Algorithmic Policing Systems, Emmanuel Sebastian Udoh Jan 2022

A Mixed Methods Exploration Of Fairness Issues In Algorithmic Policing Systems, Emmanuel Sebastian Udoh

Legacy Theses & Dissertations (2009 - 2024)

Algorithmic governance (AG) systems aim to utilize machine learning (ML) in the form of mathematical modelling and predictive analytics to achieve greater efficiency and accuracy, effect equal treatment and eliminate bias. In its application to policing, algorithmic policing (AP) or predictive policing applies tree-based risk training algorithms on criminal complaint data to predict where and when the next crime is likely to occur, and who the likeliest perpetrators and victims are. Thus, AP preemptively determines where, how, and when to deploy police resources. However, as more and more cities adopt AP, there are fears that AP may be reinforcing age-long …

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Photopolymers : Environmentally Benign Technology For A Variety Of Industries, Tatyana Tarasevich Jan 2022

Photopolymers : Environmentally Benign Technology For A Variety Of Industries, Tatyana Tarasevich

Legacy Theses & Dissertations (2009 - 2024)

Photopolymerization is a well-known process with applications in a variety of industries. Photopolymers are formed by a reaction of monomers or oligomers, photoinitiators and in some cases crosslinkers. Upon irradiation with UV or visible light, monomers undergo conformational change to form polymers via a photochemical process. Several photopolymerization types will be discussed in this thesis. End products of photopolymerizations included epoxies, inks, coatings, photoresists, etc.

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Neural Correlates And Neuroanatomy Of Juvenile And Adult Contextual Fear Memory Retention, Natalie Odynocki Jan 2022

Neural Correlates And Neuroanatomy Of Juvenile And Adult Contextual Fear Memory Retention, Natalie Odynocki

Legacy Theses & Dissertations (2009 - 2024)

AbstractFear is an evolutionarily conserved mechanism that allows an organism to discern potential harm and act accordingly by engaging in defensive behaviors. While fear is an adaptive response, dysregulation of fear by means of a traumatic event can lead to psychiatric conditions such as post-traumatic stress disorder (PTSD). Animal research using rodents in Pavlovian context fear conditioning experiments allows for the ability to study the underlying neural circuitry of threat-appropriate and aberrant fear learning and memory that may contribute to PTSD. However, despite reports that women are more than two times more likely to develop PTSD compared to men, the …

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Evaluation Of Aquatic Plant Survey Methods For Efficacy In Invasive Species Detection, Izaac Cooper Jan 2022

Evaluation Of Aquatic Plant Survey Methods For Efficacy In Invasive Species Detection, Izaac Cooper

Legacy Theses & Dissertations (2009 - 2024)

Aquatic invasive plants can often be ecologically devastating to ecosystems where they are introduced. This devastation has been widely apparent in the United States, including many locations in New York State over many decades, following anthropogenic transport of species from their native ranges. Due to the difficulty involved in eradicating these plants once they have become fully established, there is keen interest in strategies for early detection to assist with prevention and monitoring to mitigate future management costs. Invasive species detection research aims to find methods for detecting new invaders more effectively. I evaluated three detection methods for their effectiveness …

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Mechanisms By Which Protective Human Outer Surface Protein A Antibodies Block Transmission Of Borrelia Burgdorferi, Amber M. Frye Jan 2022

Mechanisms By Which Protective Human Outer Surface Protein A Antibodies Block Transmission Of Borrelia Burgdorferi, Amber M. Frye

Legacy Theses & Dissertations (2009 - 2024)

Borrelia burgdorferi (B. burgdorferi) is the causative agent of Lyme disease in the United States and Europe, which remains a major threat to public health. While currently no human Lyme disease vaccine is available, a previously licensed OspA-based vaccine was shown to effectively prevent transmission of B. burgdorferi from ticks to mammalian hosts. Concerning the vaccines mechanism of action, OspA antibodies enter the bloodmeal of a feeding tick and engage with B. burgdorferi producing OspA on their outer surface in a manner that impairs migration of the spirochete to the host; however exact antibody-spirochete interaction is unknown, despite the importance …

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Causal Exclusion And Free Will Arguments, Nicholas Jacobson Jan 2022

Causal Exclusion And Free Will Arguments, Nicholas Jacobson

Legacy Theses & Dissertations (2009 - 2024)

ABSTRACTIn my dissertation, I defend a compatibilist conception of free will against a variety of arguments against compatibilism, and free will more generally. In the process of defending compatibilist free will against these arguments, I will be fleshing out some details of what I think free will is. Along the way, I will be developing and defending some views on related concepts, such as the concept of control. An important theme I will be revisiting throughout is that these arguments against compatibilist free will assume certain things about causation, and particularly how different kinds of phenomena causally compete with each …

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Mechanisms Underlying Pre- And Postnatal Development Of The Mouse Vomeronasal Organ, Raghu Ram Katreddi Jan 2022

Mechanisms Underlying Pre- And Postnatal Development Of The Mouse Vomeronasal Organ, Raghu Ram Katreddi

Legacy Theses & Dissertations (2009 - 2024)

The Vomeronasal organ (VNO) is a specialized olfactory sensory organ located in the ventral region of the nasal cavity in rodents. The vomeronasal epithelium (VNE) of rodents is composed of 2 major types of vomeronasal sensory neurons (VSNs): 1) VSNs distributed in the apical VNE regions that express vomeronasal type-1 receptors (V1Rs) and the G protein subunit Gi2, and 2) VSNs in the basal territories of the VNE that express vomeronasal type-2 receptors (V2Rs) and the G subunit Go. Besides these two neuronal types, VNE also accommodate a third non-neuronal cell type called Sustentacular cells that lie anatomically above apical …

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Ab42 Alters Glutamatergic Transmission In The Ca1 Region Of The Mouse Hippocampus, Patrick Harry Wehrle Jan 2022

Ab42 Alters Glutamatergic Transmission In The Ca1 Region Of The Mouse Hippocampus, Patrick Harry Wehrle

Legacy Theses & Dissertations (2009 - 2024)

Alzheimer’s disease (AD) is a neurodegenerative disease affecting 4.5 million people in the US, a number expected to increase 3-fold over the next 30 years. One of the hallmarks of AD is the extracellular accumulation of the protein Aß₄₂ throughout in the brain, particularly in limbic structures like the temporal cortex and hippocampus, key regions for learning and memory. Currently available animal models for AD aim to reproduce key genetic traits of the familial variant of the disease, but >90% of AD patients are affected by idiopathic AD. To overcome this potential limitation, we use a different approach to study …

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Synthesis Of Oligonucleotides Containing Unnatural Backbone And Regulation Of Crispr Activity Using Inverse Electron Demand Diels-Alder Chemistry, Alyssa Hoy Jan 2022

Synthesis Of Oligonucleotides Containing Unnatural Backbone And Regulation Of Crispr Activity Using Inverse Electron Demand Diels-Alder Chemistry, Alyssa Hoy

Legacy Theses & Dissertations (2009 - 2024)

This thesis describes the synthesis of an oligonucleotide containing an unnatural neutralbackbone. The backbone was constructed using bio-orthogonal inverse electron demand Diels- Alder chemistry between trans-cyclooctene (TCO) and tetrazine (Tz). A TCO phosphoramidite was synthesized and attached to solid support for strand propagation. Uridine monomers containing either bis-TCO or bis-Tz were also synthesized. The oligonucleotide strand was formed by sequential ligation of the bis-Tz and bis-TCO monomers. The oligonucleotide was analyzed using mass spectrometry. This thesis also describes the synthesis of sgRNAs containing non-canonical nucleobases, m1A, m6A, s2U and s4U using the ‘split-and-click’ methodology. The synthetic sgRNAs were assembled using …

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Trace Elements In Nails And Anemia In Children Living Along The Interoceanic Highway, Madre De Dios, Peru / Narrative Competence And Cognitive Mapping As A Culturally Sustaining Pedagogy In The Education Of Emergent Bilinguals, Tia Marks Jan 2022

Trace Elements In Nails And Anemia In Children Living Along The Interoceanic Highway, Madre De Dios, Peru / Narrative Competence And Cognitive Mapping As A Culturally Sustaining Pedagogy In The Education Of Emergent Bilinguals, Tia Marks

Legacy Theses & Dissertations (2009 - 2024)

Anthropogenic changes in the Peruvian Amazon, including deforestation, highway development, agriculture, and artisanal and small-scale gold mining (ASGM), have increased community concern about potential exposures toxic trace elements (TTE) including arsenic (As), cadmium (Cd), mercury (Hg), and lead (Pb). Such exposures can lead to detrimental health effects in children, such as developmental delays and anemia. The overarching goal of my dissertation was to understand exposure to both toxic and essential (manganese (Mn), selenium (Se), and zinc (Zn)) trace elements, anemia prevalence, and the associations between hemoglobin (Hb) levels and trace elements. To do this, I leveraged existing data from a …

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Examining The Relationship Between Admission Requirements And Program Outcome Variables In A Special Education Teacher Preparation Program, Emily Woofenden Jan 2022

Examining The Relationship Between Admission Requirements And Program Outcome Variables In A Special Education Teacher Preparation Program, Emily Woofenden

Legacy Theses & Dissertations (2009 - 2024)

The need for well-prepared special education teachers makes it important to examine how to best select candidates for special education teacher preparation programs, or at least to determine which, if any, admission variables relate to program outcome measures. This study is a replication and extension of a 2012 study—it used archival data from 64 students to investigate the relationships among multiple pre-admission variables from teacher candidate applications and on-site admission tasks (undergraduate GPA, letter of reference ratings, interview ratings, math assessment scores, and a teaching skills task) and outcome variables (graduate GPA and preservice practicum teaching performance scores). The outcome …

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Genetic Regulation Within Cellular Stress Response Pathways, Jhos M. Dufflart Jan 2022

Genetic Regulation Within Cellular Stress Response Pathways, Jhos M. Dufflart

Legacy Theses & Dissertations (2009 - 2024)

Cellular stress is something that a cell deals with on a regular basis. Fortunately, there are several different mechanisms that are set in place in order to deal with them. Depending on the stress present in the cell there will be different stress response pathways that are activated in order to mitigate the stress or initiate cellular death mechanisms. Transcription factors (TFs) are key components within these pathways, and this will be the focus of this thesis. TFs within mammalian stress response pathways are tasked with the essential regulation of multiple genes within these pathways and are oftentimes linked with …

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Exploring The Roles Of Stress, Codon Usage, And Rna Modifications In Myotonic Dystrophy Type 1, Afrooz Golestanian Jan 2022

Exploring The Roles Of Stress, Codon Usage, And Rna Modifications In Myotonic Dystrophy Type 1, Afrooz Golestanian

Legacy Theses & Dissertations (2009 - 2024)

Myotonic dystrophy (DM), the most common form of muscular dystrophy, is a neuromuscular disease caused by microsatellite repeat expansions. It can represent a multi-systemic autosomal dominant disease with DM1 and DM2 subtypes. A cytosine-thymine-guanine (CTG) triplet repeat in the 3’ untranslated region (3’UTR) of myotonic dystrophy protein kinase (DMPK) gene causes DM1 disease, which leads to the production of a longer, abnormal and toxic mRNA. The toxic DMPK mRNA sequester the splicing proteins such as Muscle blind-like (MBNL) and rbFOX which leads to gene expression alteration. Repeat associated non-AUG (RAN) translation also occurs in DM1. Mitochondrial dysregulation has also been …

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The Mountain Gap Wind Of The Isthmus Of Tehuantepec And Its Impact On Tropical Cyclogenesis In The Eastern Pacific, Adolfo Lugo Rios Jan 2022

The Mountain Gap Wind Of The Isthmus Of Tehuantepec And Its Impact On Tropical Cyclogenesis In The Eastern Pacific, Adolfo Lugo Rios

Legacy Theses & Dissertations (2009 - 2024)

In this dissertation we research two aspects of the mountain gap wind northerlies of the Isthmus of Tehuantepec in Southern Mexico. The causes of extreme gap wind northerlies, emphasizing the causes by tropical weather systems, like easterly waves troughs or hurricanes, and the impacts of an extreme gap wind events on tropical cyclogenesis.Through the use of an index to diagnose the mountain gap wind strength, its evolution through the year and the mechanisms leading to extreme mountain gap winds was highlighted. The index revealed that the gap wind is strongly related to high surface pressure anomalies over the GoM throughout …

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Disability In An American Indian Community : Prevalence, Distribution, And The Role Of Polychlorinated Biphenyls, Thoin F. Begum Jan 2022

Disability In An American Indian Community : Prevalence, Distribution, And The Role Of Polychlorinated Biphenyls, Thoin F. Begum

Legacy Theses & Dissertations (2009 - 2024)

Phthalates have been implicated as reproductive toxicants in animal models and in human populations. This study examined associations between potential exposure sources and urinary phthalate concentrations among couples undergoing infertility treatment. Women (n=56) and their male partners (n=43) undergoing in vitro fertilization (IVF) were enrolled in a prospective cohort investigation of environmental chemicals and IVF outcomes at an academic medical center. On the day of oocyte retrieval, participants provided urine samples and completed questionnaires detailing use of personal care products (PCPs), and consumption of medications, foods, and beverages in the preceding 24-hours. Urine was analyzed for MEP, MBP, MPP, MHxP, …

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Phase And Dark Field Radiography And Ct With Mesh-Based Structured Illumination And Polycapillary Optics, Uttam Pyakurel Jan 2022

Phase And Dark Field Radiography And Ct With Mesh-Based Structured Illumination And Polycapillary Optics, Uttam Pyakurel

Legacy Theses & Dissertations (2009 - 2024)

Imaging can be performed with a variety of techniques. For example, gamma radiation is used in nuclear medicine and radiation therapy A challenge in using gamma rays is the risk of high radiation exposure, which requires extensive custom shielding. The transmission of gamma rays through 3D printed shielding was measured to evaluate the required thickness of the shielding.Conventional radiography depends on x-ray attenuation. Another imaging technique, X-ray phase imaging, is known to improve the contrast of images relative to conventional imaging for low density materials. Phase differences imparted by soft tissue are roughly 1000 times larger than attenuation differences. Further, …

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An Exploration Of The Relationship Between Social-Emotional Well-Being And Health Behaviors Of Urban Youth, Nelia Mayreilys Quezada Jan 2022

An Exploration Of The Relationship Between Social-Emotional Well-Being And Health Behaviors Of Urban Youth, Nelia Mayreilys Quezada

Legacy Theses & Dissertations (2009 - 2024)

A significant body of research has established that individuals lacking social support, self-esteem, and coping skills have poor physical health outcomes (House et al., 1998; Thoits, 2011; Uchino, 2009). Youth living in urban communities are at greater risk of poor mental and physical health outcomes due to a lack of access to safe places for physical activity, healthy foods, and limited social ties (Babey et al., 2016; Heller Isner et al., 2017; Thoits, 2011). This study examines the relationship between social-emotional well-being and health behaviors among youth (N=100) ages 11 to 19 in a small urban community. Based on prior …

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Rna-Seq Data Analysis Of A Human Lung Carcinoma Cell Line (A549) And Investigating The Role Of Nf-Kappa B As An Effector Of Atf3 During Zika Virus Infection, Theodora Pearl De-Veer Jan 2022

Rna-Seq Data Analysis Of A Human Lung Carcinoma Cell Line (A549) And Investigating The Role Of Nf-Kappa B As An Effector Of Atf3 During Zika Virus Infection, Theodora Pearl De-Veer

Legacy Theses & Dissertations (2009 - 2024)

The 2015 Zika virus (ZIKV) outbreak amassed international concern due to its association with the high incidence of devastating neurological conditions- microcephaly and Guillain-Barré Syndrome. Reportedly affecting over 5,000 fetal newborns, imaging studies have unveiled the pernicious effects of ZIKV infection on the fetal brain, which include cortical malformations, micrencephaly, hydrocephalus, and focal inflammation.

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"We Are The Stories" : Narrative Competence And Cognitive Mapping As A Culturally Sustaining Pedagogy In The Education Of Emergent Bilinguals, Sepideh Yasrebi Jan 2022

"We Are The Stories" : Narrative Competence And Cognitive Mapping As A Culturally Sustaining Pedagogy In The Education Of Emergent Bilinguals, Sepideh Yasrebi

Legacy Theses & Dissertations (2009 - 2024)

Much has been said about the drawbacks of “teaching to the test” in K-12 public education in the U.S. When it comes to English as a New Language (ENL), however, few studies have explored the ways in which ENL literacy and education is framed and conceptualized in the New York State Next Generation Learning Standards (NGLS), which, in turn, decisively shape ENL curriculum and instruction at schools. Considering the issues of deficits perspectives, context and pragmatics in Second Language Acquisition, mechanical approaches to writing, and narrative and agency, this study intends to reframe narrative writing around students’ lived experiences. In …

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Autonomic Nervous System Coordination : Examining The Impact Of Perceived Discrimination And Stressful Life Events, Rachel Renee Mitchell Jan 2022

Autonomic Nervous System Coordination : Examining The Impact Of Perceived Discrimination And Stressful Life Events, Rachel Renee Mitchell

Legacy Theses & Dissertations (2009 - 2024)

Literature has demonstrated the deleterious effects of discrimination on mental health. For racial and ethnic minorities, discrimination is associated with symptoms of psychopathology, including anxiety and depression. Likewise, women who report gender-based discrimination are at an elevated risk for psychopathology. Scholars have theorized that chronic stress elicited by discrimination throughout one's life contributes to this increase in risk. Indeed, a wealth of research examining the consequences of stressful and potentially traumatic life events (SLEs) on mental health has pointed to physiological dysregulation as a mechanism through which life course stress undermines health. Patterns of physiological dysregulation within the sympathetic (SNS) …

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Municipal Solutions To Climate Change ; A Case Study Of Stream Daylighting In Suffolk County, New York, Madison Hrysko Jan 2022

Municipal Solutions To Climate Change ; A Case Study Of Stream Daylighting In Suffolk County, New York, Madison Hrysko

Legacy Theses & Dissertations (2009 - 2024)

During the 1950’s and 1960’s Suffolk County, New York experienced rapid urbanization and development. To pave way for infrastructure, hydrological modifications were made to the land including the burial of naturally flowing streams. Daylighting streams is the nature-based process of bringing buried streams back to the surface. In turn, restoring ecosystem services, increasing local resilience to climate change impacts, and expanding biodiversity. Minimal research has been done using GIS technology alongside a set of criteria to select best fit streams for daylighting. This thesis aims to fill that gap by identifying best and second-best fit streams for daylighting in Suffolk …

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Uio-Type Metal-Organic Framework Derivatives As Sorbents For The Detection Of Gas-Phase Explosives, Matthew Ryan Sherrill Jan 2022

Uio-Type Metal-Organic Framework Derivatives As Sorbents For The Detection Of Gas-Phase Explosives, Matthew Ryan Sherrill

Legacy Theses & Dissertations (2009 - 2024)

The detection of energetic compounds – better known to the public as explosives – has is an important cornerstone of counterterrorism and homeland security . While significant advances have been achieved for the detection of trace explosives in various matrices such as soil, wastewater, and clothing, the detection of explosives in the gas phase remains challenging due to their infamously low vapor pressures. In this thesis, we leverage the high sensitivity of direct analysis in real-time mass spectrometry (DART-MS) and the microporosity of metal-organic frameworks (MOFs) to adsorb and therefore concentrate explosives from the vapor phase and subsequently detect them …

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Fluorescent Biosensors : Engineering And Applications, Monica Rodriguez Jan 2022

Fluorescent Biosensors : Engineering And Applications, Monica Rodriguez

Legacy Theses & Dissertations (2009 - 2024)

Neurons in the brain communicate via electrical and chemical synapses, whereneurotransmitters are released. Traditional methods to detect synaptic transmission rely on single-cell patch-clamp recordings from target neurons, but these can only provide an indirect readout of the lifetime of neurotransmitters in the extracellular space. More recently, this task has been aided by developing fluorescent biosensors with high sensitivity and large dynamic ranges. Fluorescent biosensors are typically composed of a neurotransmitter binding protein tagged with fluorescent reporter molecules. Fluorescence biosensors come in different forms, including FRET-based biosensors. These can be built using different intracellular signaling molecules and neurotransmitter binding domains. Here, …

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